Research Group on Skin Cancer
Oncology Area
Transcriptomic identification of miRNA-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma
Search for a genetic and/or epigenetic signature which permit a more precise diagnosis and prediction of the metastatic potential of ambiguous melanocytic lesions, and particularly of spitzoid tumors
Identification of circulating miRNAs which may serve as prognostic and/or staging biomarkers in patients with primary cutaneous melanoma

Coordinator
STAFF
Collaborating Researchers
Beatriz Sánchez Sendra
Nurse
Technicians
Esther Alvarez Vilanova
Administrative assistant
Publications
Trisomy 12p mosaicism syndrome in a patient with hypopigmented cutaneous mosaicism and three cell lines in peripheral blood. Porcar Saura S, Diaz Gimenez M, Guillen-Climent S, Villar C, Ruiz Quilez A, Abellan Sanchez M, Cuesta Peredo A, Martin J. Journal of the European Academy of Dermatology and Venereology. 2023 Jan;37(1):e54-e58. doi: 10.1111/jdv.18555. PMID: 35993792
Corticotroph cell hyperplasia as a rare cause of ACTH-dependent Cushing syndrome. Ferri J, Martinez-Ibanez J, Terradez L, Savall E, Martinez-Hervas S, Oller M, Lorente R, Ascaso J, Real J. Endocrinologia, Diabetes y Nutrición. 2022 Nov;69(9):694-701. doi: 10.1016/j.endien.2022.11.004. PMID: 36470644
Deep learning for skin melanocytic tumors in whole-slide images: a systematic review. Mosquera-Zamudio A, Launet L, Tabatabaei Z, Parra-Medina R, Colomer A, Moll J, Monteagudo C, Janssen E, Naranjo V. Cancers. 2022 Dec 21;15(1):42. doi: 10.3390/cancers15010042. PMID: 36612037
Fluorescent in situ hybridization (FISH): a useful diagnostic tool for childhood conjunctival melanoma. Moral R, Monteagudo C, Muriel J, Moreno L, Peiro A. European Journal of Ophthalmology. 2022 Nov;32(6):NP13-NP19. doi: 10.1177/11206721211030775. PMID: 34240653
Mercury impairs human primary endometrial stromal cell function (dagger). Palomar A, Gonzalez-Martin R, Perez-Deben S, Medina-Laver Y, Quinonero A, Dominguez F. Biology of Reproduction. 2022 May 17;106(5):1022-1032. doi: 10.1093/biolre/ioac016. PMID: 35084015
An attention-based weakly supervised framework for spitzoid melanocytic lesion diagnosis in whole slide images. Del Amor R, Launet L, Colomer A, Moscardo A, Mosquera-Zamudio A, Monteagudo C, Naranjo V. Artificial Intelligence in Medicine. 2021 Nov;121:102197. doi: 10.1016/j.artmed.2021.102197. PMID: 34763799
BASCULE syndrome associated with presyncopal episodes and first-degree atrioventricular block. Guillen-Climent S, Saura S, Benavent M, Garcia-Vazquez A, Martin J. International Journal of Dermatology. 2021 Oct;60(10):e400-e402. doi: 10.1111/ijd.15568. PMID: 33797752
Case report: primary peritonitis as the onset of pediatric Menetrier’s disease. Barres-Fernandez A, Piolatti-Luna A, Breton-Martinez J, Crehua-Gaudiza E, Quinones-Torrelo C, Moscardo-Navarro A, Fuertes-Latasa C, Martinez-Costa C. Frontiers in Pediatrics. 2021 Jan 13;8:589853. doi: 10.3389/fped.2020.589853. PMID: 33520889
CCL27 Signaling in the Tumor Microenvironment. Martinez-Rodriguez M, Monteagudo C. Advances in Experimental Medicine and Biology. 2021;1302:113-132. doi: 10.1007/978-3-030-62658-7_9. PMID: 34286445
Asymptomatic erythematous hardened plaque on the scalp. Estébanez Corrales A, Vázquez Fernández L, Terradez Mas L, Monteagudo Castro C. Clinical And Experimental Dermatology. 2020 Mar;45(2):218-221. doi: 10.1111/ced.13939. PMID: 30767268
Circulating miRNA expression analysis reveals new potential biomarkers for human cutaneous melanoma staging. Sanchez Sendra B, Garcia Gimenez J, González Muñoz J, Navarro Cerveró L, Murgui A, Terradez Mas L, Pinazo Canales M, Martin Hernandez J, Monteagudo Castro C. Journal of the European Academy of Dermatology and Venereology. 2020 Mar;34(3):e126-e129. doi: 10.1111/jdv.16060. PMID: 31710393
Depressed indurated plaque with elastorrhexis as a distinctive lesion in Buschke-Ollendorff síndrome. Velasco Huici R, Martin Hernandez J, Vázquez Fernández L, Silva Diaz E, Estébanez Corrales A, Cuesta Peredo A, Ramon Quiles M, Monteagudo Castro C. Pediatric Dermatology. 2020 Mar;37(2):385-387. doi: 10.1111/pde.14096. PMID: 31943321
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho M, Moubarak R, Sanchez Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo Castro C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E. Cancer Cell. 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007. PMID: 31935372
Projects
Title: Análisis combinado por Inteligencia Artificial de marcadores epigenéticos e imágenes microscópicas digitalizadas de tumores melanocíticos ambiguos para optimizar su clasificación diagnóstica y pronóstica
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Carlos Monteagudo Castro
Duration: 2021 – 2023
Total budget: 220.220 €
Title: Sistema de visión artificial aumentada para la caracterización molecular y morfológica del cáncer de piel
Funding body: Agencia Valenciana de la Innovación-AVI Generalitat Valenciana
Principal Investigator: Carlos Monteagudo Castro
Duration: 2021 – 2023
Total budget: 192.869 €
Title: Cloud Artificial Intelligence for pathology-CLARIFY
Funding body: European Commission
Principal Investigator: Carlos Monteagudo Castro
Duration: 2019 – 2023
Total budget: 252000
Title: electrónicos hasta los datos MULTI-ómic
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Carlos Monteagudo Castro
Duration: 2018 – 2021
Total budget: 99.220 €
+ Info
Doctoral candidate: Pérez Debén, Silvia
Director(s): Domínguez Hernández, Francisco; Remohí Giménez, José
Date of the defense: 02/06/2022
University: Universitat de València