Grupo de investigación en cáncer cutáneo

Área de Oncología


Nuestro grupo tiene como objetivo optimizar el diagnóstico y el pronóstico de los pacientes con cáncer cutáneo, y especialmente del melanoma, mediante la incorporación de nuevos marcadores moleculares. Muchos de estos marcadores, genéticos y epigenéticos, contribuyen a la medicina de precisión y permiten incorporar criterios innovadores para una mejor estratificación pronóstica que sirva para optimizar la planificación del seguimiento y tratamiento de los pacientes con cáncer cutáneo.

Dr. José Carlos Monteagudo Castro
Coordinador
Dr. José Carlos Monteagudo Castro
carlos.monteagudo@uv.es; cmonteag@uv.es

INVESTIGADORES
R4 Senior

José Carlos Monteagudo Castro    

R3 Consolidado
R2 Novel / Emergente

Liria Terrádez Mas
José Mª Martín Hernández
Silvia Pérez Deben

R1 Predoctoral
STAFF
Colaborador/a
Enfermero/a
Técnico/a

Esther Álvarez Vilanova

Apoyo
Publicaciones
CD34-negative, STAT6-negative, low-grade, low-risk solitary fibrous tumor. Monteagudo C, Perez-Deben S, Perez-Roda I, Giner F, Machado I. American Journal of Surgical Pathology. 2024 Feb 1;48(2):247-249. doi: 10.1097/PAS.0000000000002087. PMID: 37345671

A spitzoid tumor dataset with clinical metadata and whole slide images for deep learning models. Mosquera-Zamudio A, Launet L, Del Amor R, Moscardo A, Colomer A, Naranjo V, Monteagudo C. Scientific Data. 2023 Oct 16;10(1):704. doi: 10.1038/s41597-023-02585-2. PMID: 37845235

Acquired aggressive multisystemic disseminated lobular capillary haemangioma: a life threatening disorder. Monteagudo C, Porcar-Saura S, Navarro S, Burgues O, Gonzalez J, Ferrandez A, Forner M. Pathology. 2023 Aug;55(5):729-732. doi: 10.1016/j.pathol.2022.11.014. PMID: 36894353

Annotation protocol and crowdsourcing multiple instance learning classification of skin histological images: The CR-AI4SkIN dataset. Del Amor R, Pérez-Cano J, López-Pérez M, Terradez L, Aneiros-Fernandez J, Morales S, Mateos J, Molina R, Naranjo V. Artificial Intelligence in Medicine. 2023 Nov:145:102686. doi: 10.1016/j.artmed.2023.102686. PMID: 37925214

Antioxidant supplementation alleviates mercury-induced cytotoxicity and restores the implantation-related functions of primary human endometrial cells. Palomar A, Quinonero A, Medina-Laver Y, Gonzalez-Martin R, Perez-Deben S, Alama P, Dominguez F. International Journal of Molecular Sciences. 2023 May 15;24(10):8799. doi: 10.3390/ijms24108799. PMID: 37240143

Dermoscopy of abortive hemangioma: morphological study of 11 cases. Fernandez-Domper L, Silva Diaz E, Ballesteros Redondo M, Martin Hernandez J, Revert Fernandez A. Dermatology Practical & Conceptual. 2023 Apr 1;13(2):e2023098. doi: 10.5826/dpc.1302a98. PMID: 37196279

Diagnostic algorithm to subclassify atypical spitzoid tumors in low and high risk according to their methylation status. González-Muñoz J, Sánchez-Sendra B, Monteagudo C. International Journal of Molecular Sciences. 2023 Dec 25;25(1):318. doi: 10.3390/ijms25010318. PMID: 38203489

Eczematous dermatitis presenting as a clear cell acanthoma-like lesion on the nipple and areola. Ballesteros Redondo M, Fernandez Domper L, Monteagudo Castro C. Actas Dermo-Sifiliograficas. 2023 Mar 23:S0001-7310(23)00220-X. doi: 10.1016/j.ad.2022.06.028. PMID: 36965773

Extrarenal fibrillary glomerulonephritis as an unknown etiology of advanced liver disease. Alventosa Mateu C, Vilar Gimeno A, Perez Alvarez I, Carbonell Zamorano J, Castello Miralles I, Latorre Sanchez M, Jose Urquijo Ponce J, Martinez Leandro E, Terradez Mas L, Diago M. Gastroenterologia y Hepatologia. 2023 Aug 9:S0210-5705(23)00377-1. doi: 10.1016/j.gastrohep.2023.08.002. PMID: 37562769

Lymphovascular invasion and high mitotic count are associated with increased risk of recurrence in pleomorphic dermal sarcoma. Pons Benavent M, Rios-Vinuela E, Nagore E, Monteagudo C, Aguerralde M, Mata Cano D, Llombart B, Serra-Guillen C, Pinazo Canales I, Requena C, Sanmartin O. Actas Dermo-Sifiliograficas. 2023 Jul-Aug;114(7):572-579. doi: 10.1016/j.ad.2023.04.018. PMID: 37088288

Lymphovascular invasion and high mitotic count are associated with increased risk of recurrence in pleomorphic dermal sarcoma. Pons Benavent M, Rios-Vinuela E, Nagore E, Monteagudo C, Aguerralde M, Mata Cano D, Llombart B, Serra-Guillen C, Pinazo Canales I, Requena C, Sanmartin O. Actas Dermo-Sifiliograficas. 2023 Jul-Aug;114(7):T572-T579. doi: 10.1016/j.ad.2023.06.010. PMID: 37302481

Perieccrine coil elastosis: an unusual and previously unrecognized aging-related phenomenon. Monteagudo C, Alvarez E. American Journal of Dermatopathology. 2023 Jan 1;45(1):58-61. doi: 10.1097/DAD.0000000000002300. PMID: 36484609

Primary cutaneous lymphoma registry of the Spanish Academy of Dermatology and Venereology (AEDV): data for the first 5 years. Falkenhain-Lopez D, Muniesa C, Estrach M, Morillo-Andujar M, Penate Y, Acebo E, Pujol R, Garcia-Muret M, Machan S, Medina S, Botella-Estrada R, Fernandez de Misa R, Blanes M, Florez A, Perez-Paredes G, Izu R, Yanguas I, Silva-Diaz E, Perez-Ferriols A, Prieto-Torres L, Zayas A, Parera-Amer M, Perez A, Aspe L, Roman C, Sanchez-Caminero M, Bassas-Vila J, Dominguez-Aunon J, Calzado L, Navedo M, Ortiz-Prieto A, Servitje O, Polo-Rodriguez I, Torres I, Noelia Hernandez-Hernandez M, Mitxelena-Eceiza J, Garcia-Vazquez A, Garcia-Doval I, Ortiz-Romero P. Actas Dermo-Sifiliograficas. 2023 Apr;114(4):291-298. doi: 10.1016/j.ad.2022.11.010. PMID: 36529273

ProGleason-GAN: conditional progressive growing GAN for prostatic cancer Gleason grade patch synthesis. Golfe A, Del Amor R, Colomer A, Sales M, Terradez L, Naranjo V. Computer Methods and Programs in Biomedicine. 2023 Jun 25;240:107695. doi: 10.1016/j.cmpb.2023.107695. PMID: 37393742

Trisomy 12p mosaicism syndrome in a patient with hypopigmented cutaneous mosaicism and three cell lines in peripheral blood. Porcar Saura S, Diaz Gimenez M, Guillen-Climent S, Villar C, Ruiz Quilez A, Abellan Sanchez M, Cuesta Peredo A, Martin J. Journal of the European Academy of Dermatology and Venereology. 2023 Jan;37(1):e54-e58. doi: 10.1111/jdv.18555. PMID: 35993792

Atypical fibroxanthoma and pleomorphic dermal sarcoma: a two-center retrospective study of 74 cases. Rios-Vinuela E, Pons Benavent M, Monteagudo C, Nagore E, Sanmartin O. Actas Dermo-Sifiliograficas. 2022 Jun;113(6):654-656. doi: 10.1016/j.ad.2021.09.008. PMID: 35431058

Benign cephalic histiocytosis mimicking mastocytosis. Diaz E, Fernandez B, Castro C, Hernandez J. Actas Dermo-Sifiliograficas. 2022 Feb;113(2):195-198. doi: 10.1016/j.ad.2020.05.014. PMID: 35249694

Benign cephalic histiocytosis mimicking mastocytosis. Silva Diaz E, Vazquez Fernandez B, Monteagudo Castro C, Martin Hernandez J. Actas Dermo-Sifiliograficas. 2022 Feb;113(2):T195-T198. doi: 10.1016/j.ad.2022.02.001. PMID: 35244585

Clinical and pathological features of Merkel cell carcinoma: A 4-year follow-up observational retrospective study in Spain. Rios-Martin J, Rodriguez-Salas N, Vazquez-Doval F, Llombart B, Rojas-Ferrer N, Gonzalez-Vela M, Zulueta T, Monteagudo C, Aneiros-Fernandez J, Beato M, Carrillo R, Silva-Carmona M, Ayala M, Gallego E, Rodriguez-Peralto J, Fraga-Fernandez J, Fernandez-Figueras M, Barranco C, Cordoba A, Sanz-Zorrilla A, Ferrer B, Funez R, Santonja C, Saus C, Idoate M, Santos-Briz A, Onrubia J, Pinedo F, de Las Penas R. Cancer Epidemiology. 2022 Feb;76:102081. doi: 10.1016/j.canep.2021.102081. PMID: 34922051

Corticotroph cell hyperplasia as a rare cause of ACTH-dependent Cushing syndrome. Ferri J, Martinez-Ibanez J, Terradez L, Savall E, Martinez-Hervas S, Oller M, Lorente R, Ascaso J, Real J. Endocrinologia, Diabetes y Nutrición. 2022 Nov;69(9):694-701. doi: 10.1016/j.endien.2022.11.004. PMID: 36470644

Deep learning for skin melanocytic tumors in whole-slide images: a systematic review. Mosquera-Zamudio A, Launet L, Tabatabaei Z, Parra-Medina R, Colomer A, Moll J, Monteagudo C, Janssen E, Naranjo V. Cancers. 2022 Dec 21;15(1):42. doi: 10.3390/cancers15010042. PMID: 36612037

Fluorescent in situ hybridization (FISH): a useful diagnostic tool for childhood conjunctival melanoma. Moral R, Monteagudo C, Muriel J, Moreno L, Peiro A. European Journal of Ophthalmology. 2022 Nov;32(6):NP13-NP19. doi: 10.1177/11206721211030775. PMID: 34240653

Linear atrophy and cutaneous hypopigmentation after an intralesional corticosteroid injection: a rare adverse effect. Porcar Saura S, Eixarch Dualde A, Pons Benavent M, Guillen Climent S. Actas Dermo-Sifiliograficas. 2022 Nov-Dec;113(10):1001-1002. doi: 10.1016/j.ad.2021.01.025. PMID: 35667387

Mercury impairs human primary endometrial stromal cell function (dagger). Palomar A, Gonzalez-Martin R, Perez-Deben S, Medina-Laver Y, Quinonero A, Dominguez F. Biology of Reproduction. 2022 May 17;106(5):1022-1032. doi: 10.1093/biolre/ioac016. PMID: 35084015

Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the comirnaty COVID-19 vaccine in nursing home residents. Sánchez-Sendra B, Albert E, Zulaica J, Torres I, Giménez E, Botija P, Beltrán MJ, Rodado C, Geller R, Navarro D. Scientific Reports. 2022 Mar 8;12(1):3788. doi: 10.1038/s41598-022-07849-2. PMID: 35260713

Prognostic value of IGF2 mRNA-Binding Protein 3 (IGF2BP3) intratumoral expression in melanoma patients at the time of diagnosis: comparative analysis of rt-qpcr versus immunohistochemistry. Sanchez-Sendra B, Perez-Deben S, Gonzalez-Munoz JF, Murgui A, Monteagudo C. Cancers. 2022 May 7;14(9):2319. doi: 10.3390/cancers14092319. PMID: 35565448

Renal histologic findings in necropsies of Type 2 Diabetes Mellitus patients. D’Marco L, Puchades M, Escudero-Saiz V, Gimenez-Civera E, Terradez L, Moscardo A, Carbonell-Asins J, Perez-Bernat E, Torregrosa I, Moncho F, Navarro J, Gorriz J. Journal of Diabetes Research. 2022 Sep 6;2022:3893853. doi: 10.1155/2022/3893853. PMID: 36110834

The prognostic value of miR-125b, miR-200c and miR-205 in primary cutaneous malignant melanoma is independent of BRAF mutational status. Sanchez-Sendra B, Gonzalez-Munoz J, Perez-Deben S, Monteagudo C. Cancers. 2022 Mar 16;14(6):1532. doi: 10.3390/cancers14061532. PMID: 35326682

Thoracic frog roes with zosteriform distribution. Domper L, Redondo M, Hernandez J, Diaz E. Dermatology Practical & Conceptual. 2022 Apr 1;12(2):e2022047. doi: 10.5826/dpc.1202a47. PMID: 35646439

A heterozygous mutation in the RAG2 gene with cutaneous and systemic manifestations partially resembling Omenn syndrome. Estebanez A, Verdu-Amoros J, Silva E, Velasco R, Cuesta A, Monteagudo C, Martin J. Journal der Deutschen Dermatologischen Gesellschaft. 2021 Jun;19(6):906-908. doi: 10.1111/ddg.14383. PMID: 34096685

An attention-based weakly supervised framework for spitzoid melanocytic lesion diagnosis in whole slide images. Del Amor R, Launet L, Colomer A, Moscardo A, Mosquera-Zamudio A, Monteagudo C, Naranjo V. Artificial Intelligence in Medicine. 2021 Nov;121:102197. doi: 10.1016/j.artmed.2021.102197. PMID: 34763799

BASCULE syndrome associated with presyncopal episodes and first-degree atrioventricular block. Guillen-Climent S, Saura S, Benavent M, Garcia-Vazquez A, Martin J. International Journal of Dermatology. 2021 Oct;60(10):e400-e402. doi: 10.1111/ijd.15568. PMID: 33797752

Case report: primary peritonitis as the onset of pediatric Menetrier’s disease. Barres-Fernandez A, Piolatti-Luna A, Breton-Martinez J, Crehua-Gaudiza E, Quinones-Torrelo C, Moscardo-Navarro A, Fuertes-Latasa C, Martinez-Costa C. Frontiers in Pediatrics. 2021 Jan 13;8:589853. doi: 10.3389/fped.2020.589853. PMID: 33520889

CCL27 Signaling in the Tumor Microenvironment. Martinez-Rodriguez M, Monteagudo C. Advances in Experimental Medicine and Biology. 2021;1302:113-132. doi: 10.1007/978-3-030-62658-7_9. PMID: 34286445

Characteristics of mucocutaneous vascular malformations drawn from a decade of a multidisciplinary committee experience. Estebanez A, Puche-Torres M, Garcia J, Cunat A, Canales M, Felix M, Campos S, Canada J, Hernandez J. Dermatologic Therapy. 2021 Sep;34(5):e15074. doi: 10.1111/dth.15074. PMID: 34338412

Cutaneous lymphadenoma is a distinct trichoblastoma-like lymphoepithelial tumor with diffuse androgen receptor immunoreactivity, notch1 ligand in reed-sternberg-like cells, and common EGFR somatic mutations. Monteagudo C, Funez R, Sanchez-Sendra B, Gonzalez-Munoz JF, Nieto G, Alfaro-Cervello C, Murgui A, Barr R. The American Journal of Surgical Pathology. 2021 Oct 1;45(10):1382-1390. doi: 10.1097/PAS.0000000000001727. PMID: 34232601

Folliculotropic mycosis fungoides with flexural eruptive cysts and comedones in a 14-year-old boy. Roca-Gines J, Alfaro-Cervello C, Sanchez-Arraez J, Torres-Navarro I, Navarro-Mira MA, Monteagudo C, Botella-Estrada R. American Journal of Dermatopathology. 2021 Sep 1;43(9):656-658. doi: 10.1097/DAD.0000000000001958. PMID: 33989213

IgA-dominant infection-associated glomerulonephritis following SARS-CoV-2 infection. Perez A, Torregrosa I, D’Marco L, Juan I, Terradez L, Solis M, Moncho F, Carda-Batalla C, Forner M, Gorriz J. Viruses-Basel. 2021 Mar 31;13(4):587. doi: 10.3390/v13040587. PMID: 33807151

Intraoperative scintigraphy with portable gamma camera for the localization of interaortocaval paraganglioma. Perez Santiago L, Cassinello Fernandez N, Alfonso Ballester R, Diaz Exposito R, Moscardo Navarro A, Ortega Serrano J. Clinical Nuclear Medicine. 2021 Nov 1;46(11):e543-e547. doi: 10.1097/RLU.0000000000003717. PMID: 34183502

Kutane und systemische veränderungen mit ähnlichkeiten zum omenn-syndrom bei heterozygoter mutation im RAG2-Gen. Estébanez A, Verdú-Amorós J, Silva E, Velasco R, Cuesta A, Monteagudo C, Martín JM. Journal der Deutschen Dermatologischen Gesellschaft. 2021 Jun;19(6):906-908. doi: 10.1111/ddg.14383_g. PMID: 34139086

Melanocytic Hyperactivation Simulating an Acral Lentiginous Melanoma in a Patient With Parkinson Disease Treated by Levodopa. Porcar Saura S, Guillen Climent S, Pinazo Canales M, Monteagudo C. American Journal of dermatopathology. 2021 Mar 1;43(3):238-241. doi: 10.1097/DAD.0000000000001807. PMID: 33595233

Morpheaform Plaques and an Infiltrated Scar: Answer. Garcia-Vazquez A, Guillen-Climent S, Silva E, Estebanez A, Ramon Quiles MD. American Journal of Dermatopathology. 2021 Aug 1;43(8):595-596. doi: 10.1097/DAD.0000000000001810. PMID: 34276028

Morpheaform Plaques and an Infiltrated Scar: Challenge. Garcia-Vazquez A, Guillen-Climent S, Silva E, Estebanez A, Ramon Quiles MD. American Journal of Dermatopathology. 2021 Aug 1;43(8):e89-e90. doi: 10.1097/DAD.0000000000001811. PMID: 34276032

Painful cutaneous lesions on the hand palm after Takotsubo cardiomyopathy and coronary angiography. Guillen-Climent S, Garcia-Vazquez A, Benavent M, Saura S, Canales I, Monteagudo C. Clinical and Experimental Dermatology. 2021 Mar;46(2):387-390. doi: 10.1111/ced.14475. PMID: 33091167

Patients with Primary Cutaneous Lymphoma are at risk for severe COVID-19. Data from the Spanish Primary Cutaneous Lymphoma Registry. Sanchez-Velazquez A, Bauer-Alonso A, Estrach T, Vega-Diez D, Garcia-Muret P, Haya L, Penate Y, Acebo E, Fernandez de Misa R, Blanes M, Suh-Oh HJ, Izu R, Silva-Diaz E, Sarriugarte J, Roman-Curto C, Botella-Estrada R, Mateu-Puchades A, Prieto-Torres L, Morillas V, Morillo M, Sanchez-Caminero P, Calzado L, Perez-Ferriols A, Perez A, Dominguez JD, Navedo M, Muniesa C, Combalia A, Arroyo-Andres J, Descalzo MA, Garcia-Doval I, Ortiz-Romero PL. Journal of the European Academy of Dermatology and Venereology. 2021 Oct;35(10):e624-e626. doi: 10.1111/jdv.17430. PMID: 34062018

Pseudoxanthoma elasticum-like syndrome with coagulation deficiency associated with carotid artery hypoplasia and a novel gamma-glutamyl carboxylase gene mutation. Guillen-Climent S, Garcia-Vazquez A, Silva E, Estebanez A, Peredo A, Ruiz M, Monteagudo C, Quiles M. International Journal of Dermatology. 2021 Jan;60(1):e13-e15. doi: 10.1111/ijd.15147. PMID: 32808310

Soft nodule on the heel in an elderly male patient: answer. Benavent M, Guillen-Climent S, Martinez-Casimiro L, Fabra M, Castro C. American Journal of Dermatopathology. 2021 Sep 1;43(9):674-675. doi: 10.1097/DAD.0000000000001882. PMID: 34411022

Soft nodule on the heel in an elderly male patient: challenge. Benavent M, Guillen-Climent S, Martinez-Casimiro L, Fabra M, Castro C. American Journal of Dermatopathology. 2021 Sep 1;43(9):e102-e103. doi: 10.1097/DAD.0000000000001883. PMID: 34411026

Proyectos
Referencia: INNEST/2021/302/58
Título: Sistema de visión artificial aumentada para la caracterización molecular y morfológica del cáncer de piel
Entidad Financiadora: Agencia Valenciana de la Innovación-AVI Generalitat Valenciana
Investigador principal: Carlos Monteagudo Castro
Duración: 2021 – 2023
Presupuesto: 192.869 €
Referencia: PI20/00094
Título: Análisis combinado por Inteligencia Artificial de marcadores epigenéticos e imágenes microscópicas digitalizadas de tumores melanocíticos ambiguos para optimizar su clasificación diagnóstica y pronóstica
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Monteagudo Castro
Duración: 2021 – 2023
Presupuesto: 220.220 €
Referencia: 860627- CLARIFY
Título: Cloud Artificial Intelligence for pathology-CLARIFY
Entidad Financiadora: European Commission
Investigador principal: Carlos Monteagudo Castro
Duración: 2019 – 2023
Presupuesto: 252000
Referencia: PI17/02019
Título: electrónicos hasta los datos MULTI-ómic
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Monteagudo Castro
Duración: 2018 – 2021
Presupuesto: 99.220 €
+ Información
Título: Análisis comparativo de perfiles proteómicos endometriales y estudio del efecto disruptor del cobre y plomo sobre la receptividad endometrial
Doctorando: Pérez Debén, Silvia
Director: Domínguez Hernández, Francisco; Remohí Giménez, José
Fecha: 02/06/2022
Universidad: Universitat de València