Grupo de investigación en cáncer cutáneo

Área de Oncología

Identificación transcriptómica de genes diana del miARN-205 potencialmente involucrados en la metástasis y supervivencia del melanoma maligno cutáneo

Búsqueda de una firma genética y / o epigenética que permita un diagnóstico y predicción más precisos del potencial metastásico de lesiones melanocíticas ambiguas, y particularmente de tumores spitzoides

Identificación de miARN circulantes que pueden servir como biomarcadores de pronóstico y / o estadificación en pacientes con melanoma cutáneo primario

Coordinador
Dr. José Carlos Monteagudo Castro
carlos.monteagudo@uv.es/cmonteag@uv.es

INVESTIGADORES
R4 Senior

José Carlos Monteagudo Castro    

R3 Consolidado
R2 Novel / Emergente

José Mª Martín Hernández
Liria Terrádez Mas

R1 Predoctoral

Anaïs Moscardó Navarro
Andrés Mosquera Zamudio
Esmeralda Silva Díaz
Santiago Guillen Climent
Silvia Pérez Debén

STAFF
Colaborador/a

Beatriz Sánchez Sendra
Inés Escandell González
Jaime Agustí Martínez

Enfermero/a
Técnico/a
Apoyo
Publicaciones
Clinical and pathological features of Merkel cell carcinoma: A 4-year follow-up observational retrospective study in Spain. Rios-Martin J, Rodriguez-Salas N, Vazquez-Doval F, Llombart B, Rojas-Ferrer N, Gonzalez-Vela M, Zulueta T, Monteagudo C, Aneiros-Fernandez J, Beato M, Carrillo R, Silva-Carmona M, Ayala M, Gallego E, Rodriguez-Peralto J, Fraga-Fernandez J, Fernandez-Figueras M, Barranco C, Cordoba A, Sanz-Zorrilla A, Ferrer B, Funez R, Santonja C, Saus C, Idoate M, Santos-Briz A, Onrubia J, Pinedo F, de Las Penas R. Cancer Epidemiology. 2022 Feb;76:102081. doi: 10.1016/j.canep.2021.102081. PMID: 34922051

The prognostic value of miR-125b, miR-200c and miR-205 in primary cutaneous malignant melanoma is independent of BRAF mutational status. Sanchez-Sendra B, Gonzalez-Munoz J, Perez-Deben S, Monteagudo C. Cancers. 2022 Mar 16;14(6):1532. doi: 10.3390/cancers14061532. PMID: 35326682

A heterozygous mutation in the RAG2 gene with cutaneous and systemic manifestations partially resembling Omenn syndrome. Estebanez A, Verdu-Amoros J, Silva E, Velasco R, Cuesta A, Monteagudo C, Martin J. Journal der Deutschen Dermatologischen Gesellschaft. 2021 Jun;19(6):906-908. doi: 10.1111/ddg.14383. PMID: 34096685

An attention-based weakly supervised framework for spitzoid melanocytic lesion diagnosis in whole slide images. Del Amor R, Launet L, Colomer A, Moscardo A, Mosquera-Zamudio A, Monteagudo C, Naranjo V. Artificial Intelligence in Medicine. 2021 Nov;121:102197. doi: 10.1016/j.artmed.2021.102197. PMID: 34763799

BASCULE syndrome associated with presyncopal episodes and first-degree atrioventricular block. Guillen-Climent S, Saura S, Benavent M, Garcia-Vazquez A, Martin J. International Journal of Dermatology. 2021 Oct;60(10):e400-e402. doi: 10.1111/ijd.15568. PMID: 33797752

Case report: primary peritonitis as the onset of pediatric Menetrier’s disease. Barres-Fernandez A, Piolatti-Luna A, Breton-Martinez J, Crehua-Gaudiza E, Quinones-Torrelo C, Moscardo-Navarro A, Fuertes-Latasa C, Martinez-Costa C. Frontiers in Pediatrics. 2021 Jan 13;8:589853. doi: 10.3389/fped.2020.589853. PMID: 33520889

CCL27 Signaling in the Tumor Microenvironment. Martinez-Rodriguez M, Monteagudo C. Advances in Experimental Medicine and Biology. 2021;1302:113-132. doi: 10.1007/978-3-030-62658-7_9. PMID: 34286445

Characteristics of mucocutaneous vascular malformations drawn from a decade of a multidisciplinary committee experience. Estebanez A, Puche-Torres M, Garcia J, Cunat A, Canales M, Felix M, Campos S, Canada J, Hernandez J. Dermatologic Therapy. 2021 Sep;34(5):e15074. doi: 10.1111/dth.15074. PMID: 34338412

Cutaneous lymphadenoma is a distinct trichoblastoma-like lymphoepithelial tumor with diffuse androgen receptor immunoreactivity, notch1 ligand in reed-sternberg-like cells, and common EGFR somatic mutations. Monteagudo C, Funez R, Sanchez-Sendra B, Gonzalez-Munoz JF, Nieto G, Alfaro-Cervello C, Murgui A, Barr R. The American Journal of Surgical Pathology. 2021 Oct 1;45(10):1382-1390. doi: 10.1097/PAS.0000000000001727. PMID: 34232601

Fluorescent in situ hybridization (FISH): a useful diagnostic tool for childhood conjunctival melanoma. Moral R, Monteagudo C, Muriel J, Moreno L, Peiro A. European Journal of Ophthalmology. 2021 Jul 9:11206721211030775. doi: 10.1177/11206721211030775. PMID: 34240653

Folliculotropic mycosis fungoides with flexural eruptive cysts and comedones in a 14-year-old boy. Roca-Gines J, Alfaro-Cervello C, Sanchez-Arraez J, Torres-Navarro I, Navarro-Mira MA, Monteagudo C, Botella-Estrada R. American Journal of Dermatopathology. 2021 Sep 1;43(9):656-658. doi: 10.1097/DAD.0000000000001958. PMID: 33989213

IgA-dominant infection-associated glomerulonephritis following SARS-CoV-2 infection. Perez A, Torregrosa I, D’Marco L, Juan I, Terradez L, Solis M, Moncho F, Carda-Batalla C, Forner M, Gorriz J. Viruses-Basel. 2021 Mar 31;13(4):587. doi: 10.3390/v13040587. PMID: 33807151

Intraoperative scintigraphy with portable gamma camera for the localization of interaortocaval paraganglioma. Perez Santiago L, Cassinello Fernandez N, Alfonso Ballester R, Diaz Exposito R, Moscardo Navarro A, Ortega Serrano J. Clinical Nuclear Medicine. 2021 Nov 1;46(11):e543-e547. doi: 10.1097/RLU.0000000000003717. PMID: 34183502

Kutane und systemische veränderungen mit ähnlichkeiten zum omenn-syndrom bei heterozygoter mutation im RAG2-Gen. Estébanez A, Verdú-Amorós J, Silva E, Velasco R, Cuesta A, Monteagudo C, Martín JM. Journal der Deutschen Dermatologischen Gesellschaft. 2021 Jun;19(6):906-908. doi: 10.1111/ddg.14383_g. PMID: 34139086

Melanocytic Hyperactivation Simulating an Acral Lentiginous Melanoma in a Patient With Parkinson Disease Treated by Levodopa. Porcar Saura S, Guillen Climent S, Pinazo Canales M, Monteagudo C. American Journal of dermatopathology. 2021 Mar 1;43(3):238-241. doi: 10.1097/DAD.0000000000001807. PMID: 33595233

Morpheaform Plaques and an Infiltrated Scar: Answer. Garcia-Vazquez A, Guillen-Climent S, Silva E, Estebanez A, Ramon Quiles MD. American Journal of Dermatopathology. 2021 Aug 1;43(8):595-596. doi: 10.1097/DAD.0000000000001810. PMID: 34276028

Morpheaform Plaques and an Infiltrated Scar: Challenge. Garcia-Vazquez A, Guillen-Climent S, Silva E, Estebanez A, Ramon Quiles MD. American Journal of Dermatopathology. 2021 Aug 1;43(8):e89-e90. doi: 10.1097/DAD.0000000000001811. PMID: 34276032

Painful cutaneous lesions on the hand palm after Takotsubo cardiomyopathy and coronary angiography. Guillen-Climent S, Garcia-Vazquez A, Benavent M, Saura S, Canales I, Monteagudo C. Clinical and Experimental Dermatology. 2021 Mar;46(2):387-390. doi: 10.1111/ced.14475. PMID: 33091167

Patients with Primary Cutaneous Lymphoma are at risk for severe COVID-19. Data from the Spanish Primary Cutaneous Lymphoma Registry. Sanchez-Velazquez A, Bauer-Alonso A, Estrach T, Vega-Diez D, Garcia-Muret P, Haya L, Penate Y, Acebo E, Fernandez de Misa R, Blanes M, Suh-Oh HJ, Izu R, Silva-Diaz E, Sarriugarte J, Roman-Curto C, Botella-Estrada R, Mateu-Puchades A, Prieto-Torres L, Morillas V, Morillo M, Sanchez-Caminero P, Calzado L, Perez-Ferriols A, Perez A, Dominguez JD, Navedo M, Muniesa C, Combalia A, Arroyo-Andres J, Descalzo MA, Garcia-Doval I, Ortiz-Romero PL. Journal of the European Academy of Dermatology and Venereology. 2021 Oct;35(10):e624-e626. doi: 10.1111/jdv.17430. PMID: 34062018

Pseudoxanthoma elasticum-like syndrome with coagulation deficiency associated with carotid artery hypoplasia and a novel gamma-glutamyl carboxylase gene mutation. Guillen-Climent S, Garcia-Vazquez A, Silva E, Estebanez A, Peredo A, Ruiz M, Monteagudo C, Quiles M. International Journal of Dermatology. 2021 Jan;60(1):e13-e15. doi: 10.1111/ijd.15147. PMID: 32808310

Soft nodule on the heel in an elderly male patient: answer. Benavent M, Guillen-Climent S, Martinez-Casimiro L, Fabra M, Castro C. American Journal of Dermatopathology. 2021 Sep 1;43(9):674-675. doi: 10.1097/DAD.0000000000001882. PMID: 34411022

Soft nodule on the heel in an elderly male patient: challenge. Benavent M, Guillen-Climent S, Martinez-Casimiro L, Fabra M, Castro C. American Journal of Dermatopathology. 2021 Sep 1;43(9):e102-e103. doi: 10.1097/DAD.0000000000001883. PMID: 34411026

A pigmented and eroded lesion on the buttock. Vázquez Fernández L, Estébanez Corrales A, García Vázquez A, Ramon Quiles M, Monteagudo Castro C. Clinical And Experimental Dermatology. 2020 Mar;45(2):225-228. doi: 10.1111/ced.13942. PMID: 30809824

Asymptomatic erythematous hardened plaque on the scalp. Estébanez Corrales A, Vázquez Fernández L, Terradez Mas L, Monteagudo Castro C. Clinical And Experimental Dermatology. 2020 Mar;45(2):218-221. doi: 10.1111/ced.13939. PMID: 30767268

Circulating miRNA expression analysis reveals new potential biomarkers for human cutaneous melanoma staging. Sanchez Sendra B, Garcia Gimenez J, González Muñoz J, Navarro Cerveró L, Murgui A, Terradez Mas L, Pinazo Canales M, Martin Hernandez J, Monteagudo Castro C. Journal of the European Academy of Dermatology and Venereology. 2020 Mar;34(3):e126-e129. doi: 10.1111/jdv.16060. PMID: 31710393

Depressed indurated plaque with elastorrhexis as a distinctive lesion in Buschke-Ollendorff síndrome. Velasco Huici R, Martin Hernandez J, Vázquez Fernández L, Silva Diaz E, Estébanez Corrales A, Cuesta Peredo A, Ramon Quiles M, Monteagudo Castro C. Pediatric Dermatology. 2020 Mar;37(2):385-387. doi: 10.1111/pde.14096. PMID: 31943321

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho M, Moubarak R, Sanchez Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo Castro C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E. Cancer Cell. 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007. PMID: 31935372

Gianotti-Crosti syndrome-like reaction secondary to Molluscum contagiosum. Estebanez A, Silva E, Guillen S, Garcia A, Martin JM. Anales de Pediatria. 2020 Jul;93(1):49-50. doi: 10.1016/j.anpedi.2019.06.016. PMID: 31635922

Identification of a Novel BRCA1 Alteration in Recurrent Melanocytoma Resulting in Increased Proliferation. San Miguel Diez T, Navarro Cerveró L, Sanchez Sendra B, Megias Vericat J, Muñoz Hidalgo L, Santonja Lopez N, Lopez Gines C, Cerda Nicolas M. Journal of Neuropathology and Experimental Neurology. 2020 Nov 1;79(11):1233-1238. doi: 10.1093/jnen/nlaa089. PMID: 32974655

Intrasinusoidal HHV8-EBV-Positive Large B-Cell Lymphoma With Features of Germinotropic Lymphoproliferative Disorder. Martínez Ciarpaglini M, Valkov A, Hurtado M, Agusti Martinez J, Malave G, Ferrandez Izquierdo A. International Journal of Surgical Pathology. 2020 Oct;28(7):804-811. doi: 10.1177/1066896920921238. PMID: 32423260

Levetiracetam-induced pediatric toxic epidermal necrolysis successfully treated with etanercept. Estébanez Corrales A, Saez-Martin L, Muñoz Bonet J, Silva Diaz E, Monrabal A, Monteagudo Castro C, Ramon Quiles M. Pediatric Dermatology. 2020 Jul;37(4):701-705. doi: 10.1111/pde.14179. PMID: 32319121

Reply to «Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation. Is it a new variant of sarcomatoid basal cell carcinoma or a collision tumor composed of a myoepithelial carcinoma and an incidental basal cell carcinoma?». Mestre Alagarda C, Monteagudo Castro C. Journal of Cutaneous Pathology. 2020 Jun;47(6):578-580. doi: 10.1111/cup.13685. PMID: 32181509

Synovial chondromatosis of the knee. A rare cause of knee pain in pediatric age. Guillen Botaya E, Pino Almero L, Molini Menchón M, Silvestre Muñoz A, Moscardó Navarro A, Minguez Rey M. Archivos Argentinos de Pediatria. 2020 Feb;118(1):e34-e40. doi: 10.5546/aap.2020.e34. PMID: 31984706

Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma. Sanchez Sendra B, Serna García E, Navarro Cerveró L, González Muñoz J, Portero Trigo J, Ramos Jarero A, Murgui Faubel A, Monteagudo Castro C. Scientific Reports. 2020 Mar 16;10(1):4771. doi: 10.1038/s41598-020-61637-4. PMID: 32179834

Type V aplasia cutis congenita in a preterm newborn successfully resolved. Silva Diaz E, Molini Menchón M, Estébanez Corrales A, García Vázquez A, Estañ Capell J, Saez Martin L, Martin Hernandez J. Dermatologic Therapy. 2020 Nov;33(6):e13888. doi: 10.1111/dth.13888. PMID: 32567088

Proyectos
Referencia: INNEST/2021/302/58
Título: Sistema de visión artificial aumentada para la caracterización molecular y morfológica del cáncer de piel
Entidad Financiadora: Agencia Valenciana de la Innovación-AVI Generalitat Valenciana
Investigador principal: Carlos Monteagudo Castro
Duración: 2021 – 2023
Presupuesto: 192.869 €

Referencia: PI20/00094
Título: Análisis combinado por Inteligencia Artificial de marcadores epigenéticos e imágenes microscópicas digitalizadas de tumores melanocíticos ambiguos para optimizar su clasificación diagnóstica y pronóstica
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Monteagudo Castro
Duración: 2021 – 2023
Presupuesto: 220.220 €

Referencia: 860627- CLARIFY
Título: Cloud Artificial Intelligence for pathology-CLARIFY
Entidad Financiadora: European Commission
Investigador principal: Carlos Monteagudo Castro
Duración: 2019 – 2023
Presupuesto: 252000

Referencia: PI17/02019
Título: Estudio del valor del patrón de metilación y variaciones del número de copias del genoma para determinar el grado de malignidad en los tumores melanocíticos de potencial maligno incierto
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Monteagudo Castro
Duración: 2018 – 2021
Presupuesto: 99.220 €

+ Información
Empresa: Nela Biodynamics
Año de incio: 2019
Investigadores: Expósito Ollero, José
Web: http://www.nelabiodynamics.com/