Research Group on Endothelial Cells (LINCE)
Cardiovascular Area
The LInCE group was established in 2000 as a basic research group with a translational vocation. Our scientific objectives are mainly focused on studying the vascular effects of sex hormones and their relationship with sex differences in cardiovascular physiology and pathophysiology. To this end, we search for new signalling pathways regulated by sex hormones in experiments performed in patients, experimental animals and cultured cells, mainly endothelial cells.
As a result of its scientific activity, the LInCE group has developed 40 competitive research projects funded by regional, national and international agencies, has published more than 150 articles, and has presented more than 200 communications to national and international scientific congresses.
A large part of its activity is carried out in collaboration with different national and international research groups, supported by collaborative projects and by participation in national and international research networks.
The group has trained a large number of predoc and postdoc researchers. Most of them are currently active in some of the best international research institutions.
In addition to an accredited group in the cardiovascular research line of INCLIVA, it is a group recognized by the University of Valencia (GIUV2013-009).
Coordinator
Coordinator
STAFF
Collaborating Researchers
Nurse
Technicians
Administrative assistant
Publications
Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems. Spinetti G, Mutoli M, Greco S, Riccio F, Ben-Aicha S, Kenneweg F, Jusic A, de Gonzalo-Calvo D, Nossent A, Novella S, Kararigas G, Thum T, Emanueli C, Devaux Y, Martelli F. Cardiovascular Diabetology. 2023 May 24;22(1):122. doi: 10.1186/s12933-023-01842-3. PMID: 37226245
Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells. Perez-Cremades D, Bueno-Beti C, Garcia-Gimenez J, Ibanez-Cabellos J, Pallardo F, Hermenegildo C, Novella S. Journal of Physiology and Biochemistry. 2023 May;79(2):251-260. doi: 10.1007/s13105-022-00935-z. PMID: 36464762
Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis. Cheng H, Perez-Cremades D, Zhuang R, Jamaiyar A, Wu W, Chen J, Tzani A, Stone L, Plutzky J, Ryan T, Goodney P, Creager M, Sabatine M, Bonaca M, Feinberg M. JCI Insight. 2023 May 22;8(10):e163041. doi: 10.1172/jci.insight.163041. PMID: 37097749
MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia. McCoy MG, Jamaiyar A, Sausen G, Cheng HS, Perez-Cremades D, Zhuang R, Chen J, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MW. Angiogenesis. 2023 Feb;26(1):107-127. doi: 10.1007/s10456-022-09856-3. PMID: 36074222
Circulating miRNA fingerprint and endothelial function in myocardial infarction: comparison at acute event and one-year follow-up. Mompeon A, Perez-Cremades D, Paes A, Sanchis J, Ortega-Paz L, Andrea R, Brugaletta S, Sabate M, Novella S, Dantas A, Hermenegildo C. Cells. 2022 Jun 2;11(11):1823. doi: 10.3390/cells11111823. PMID: 35681518
Dysregulated genes, MicroRNAs, biological pathways, and gastrocnemius muscle fiber types associated with progression of peripheral artery disease: a preliminary análisis. Saini S, Perez-Cremades D, Cheng H, Kosmac K, Peterson C, Li L, Tian L, Dong G, Wu K, Bouverat B, Wohlgemuth S, Ryan T, Sufit R, Ferrucci L, McDermott M, Leeuwenburgh C, Feinberg M. Journal of the American Heart Association. 2022 Nov;11(21):e023085. doi: 10.1161/JAHA.121.023085. PMID: 36300658
Editorial: Genetic and gene regulation underlying sex differences in cardiovascular disease. Robinson E, Novella S. Frontiers in Cardiovascular Medicine. 2022 Apr 11;9:881154. doi: 10.3389/fcvm.2022.881154. PMID: 35479282
Endothelial cell-specific deletion of a microRNA accelerates aterosclerosis. Yang D, Haemmig S, Chen J, McCoy M, Cheng H, Zhou H, Cheng X, Sun X, Haneo-Mejia J, Vellarikkal S, Gupta R, Barrera V, Perez Cremades D, Feinberg M. Atherosclerosis. 2022 Jun;350:9-18. doi: 10.1016/j.atherosclerosis.2022.04.010. PMID: 35462240
Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway. Yang D, Haemmig S, Zhou H, Perez-Cremades D, Sun X, Chen L, Li J, Haneo-Mejia J, Yang T, Hollan I, Feinberg M. Elife. 2021 Jan 8;10:e58064. doi: 10.7554/eLife.58064. PMID: 33416495
MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance. Becker-Greene D, Li H, Perez-Cremades D, Wu W, Bestepe F, Ozdemir D, Niosi C, Aydogan C, Orgill D, Feinberg M, Icli B. Cellular and Molecular Life Sciences. 2021 Dec;78(23):7663-7679. doi: 10.1007/s00018-021-03960-1. PMID: 34698882
Regulatory network analysis in estradiol-treated human endothelial cells. Perez-Cremades D, Paes A, Vidal-Gomez X, Mompeon A, Hermenegildo C, Novella S. International Journal of Molecular Sciences. 2021 Jul 30;22(15):8193. doi: 10.3390/ijms22158193. PMID: 34360960
Approaching Sex Differences in Cardiovascular Non-Coding RNA Research. Jusic A, Salgado-Somoza A, PAES MARTÍ A, Stefanizzi F, Martínez Alarcón N, Pinet F, Martelli F, Devaux Y, Robinson E, Novella Del Campo S, On Behalf Of The Eu-Cardiorna Cost Action. International Journal of Molecular Sciences. 2020 Jul 10;21(14):4890. doi: 10.3390/ijms21144890. PMID: 32664454
Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs. Pierce J, Simion V, Icli B, Perez-Cremades D, Cheng H, Feinberg M. Genes. 2020 Nov 16;11(11):1354. doi: 10.3390/genes11111354. PMID: 33207533
Disparate miRNA expression in serum and plasma of patients with acute myocardial infarction: a systematic and paired comparative analysis. Mompeon Campos A, Ortega-Paz L, Vidal Gomez X, Costa T, Perez Gil D, Garcia Blas S, Brugaletta S, Sanchis Fores J, Sabate M, Novella Del Campo S, Dantas A, Hermenegildo Caudedevilla C. Scientific Reports. 2020 Mar 25;10(1):5373. doi: 10.1038/s41598-020-61507-z. PMID: 32214121
MiR-4674 regulates angiogenesis in tissue injury by targeting p38K signaling in endothelial cells. Icli B, Li H, Perez Cremades D, Wu W, Ozdemir D, Haemmig S, Guimaraes R, Manica A, Marchini J, Orgill D, Feinberg M. American Journal of Physiology-Cell Physiology. 2020 Mar 1;318(3):C524-C535. doi: 10.1152/ajpcell.00542.2019. PMID: 31913696
Projects
Title: Mecanismos moleculares de las rutas de señalización de los miRNA modificados por infarto agudo de miocardio. Influencia del sexo y el envejecimiento.
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Suanna Novella del Campo, Carlos Hermenegildo Caudevilla
Duration: 2023 – 2025
Total budget: 111.320,00 €
Title: Network for implementing multiomics approaches in atherosclerotic cardiovascular disease prevention and research (AtheroNET).
Funding body: European Commission
Principal Investigator: Paolo Magni
Duration: 2022 – 2025
Total budget: 0
Title: Caracterización de un modelo murino experimental de insuficiencia cardiaca para estudios transcriptómicos.
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Daniel Pérez Cremades
Duration: 2022 – 2023
Total budget: 20.000 €
Title: Análisis funcional de las rutas de señalización vascular reguladas por miRNA sensibles a estrógenos
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Susana Novella del Campo, Carlos Hermenegildo Caudevilla
Duration: 2022 – 2024
Total budget: 90.000 €
Title: Regulación dependiente de sexo y estrógenos en el síndrome coronario agudo e impacto funcional en células endoteliales humanas. Nuevos biomarcadores para prevención primaria
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Carlos Hermenegildo Caudevilla, Susana Novella Del Campo
Duration: 2020 – 2023
Total budget: 159.720 €
Title: Repercusión en la función vascular de miRNA regulados por estrógenos
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Susana Novella del Campo
Duration: 2020 – 2021
Total budget: 40000
Title: Catalysing transcriptomics research in cardiovascular disease
Funding body: European Commission
Principal Investigator: Yvan Devaux
Duration: 2018 – 2023
Total budget: 0
Title: Perfil plasmático de miRNA en infarto agudo de miocardio: relación con la evolución clínica en pacientes y con la función cardiovascular y posible terapia con micropartículas en ratones
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Carlos Hermenegildo Caudevilla
Duration: 2017 – 2020
Total budget: 134.915 €
+ Info
Doctoral candidate: Mompeón Campos, Ana
Director(s): Hermenegildo Caudevilla, Carlos; Novella Del Campo, Susana
Date of the defense: 04/03/2019
University: Universitat de València