Dr. Carlos Hermenegildo Caudevilla

Principal Investigator
Research Group on Endothelial Cells (LINCE)


He studied Medicine and Surgery at the Faculty of Medicine of the University of Valencia, where he graduated in 1990, and obtained his doctorate with extraordinary honour three years later.

After a postdoctoral research training at the Instituto de Investigaciones Citológicas and in Canada, between 2000 and 2008 he worked as a researcher at the Carlos III Health Institute, first at the Hospital Clínico de Valencia and then at its Research Foundation. In 2008, he obtained an Assistant Professor position, and since 2012 is Full Professor in the Department of Physiology of the University of Valencia.

His research is focused on the changes that sex hormones, mainly estrogens, induce in the physiology and pathophysiology of the endothelium. Through a genetic and cell biology approach, he studies its repercussions on menopause, aging, hypertension and acute coronary syndrome. He has published more than 140 scientific papers, and more than 190 communications to national and international congresses, is a regular contributor to prestigious international journals, and has directed more than 25 doctoral theses and master’s thesis.

He has been principal investigator of 30 competitive research projects, obtaining continued competitive public funding for the last 25 years. He has been Coordinator of the Central Research Unit of the Faculty of Medicine (UCIM). He is currently Vice-Principal for Research of the University of Valencia, member of the R+D section of the CRUE, coordinator of REBIUN (Network of Spanish University Libraries) and president of RUVID (Network of Valencian Universities for the promotion of Research, Development and Innovation).

Dr. Carlos Hermenegildo Caudevilla
Dr. Carlos Hermenegildo Caudevilla


Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells. Perez-Cremades D, Bueno-Beti C, Garcia-Gimenez J, Ibanez-Cabellos J, Pallardo F, Hermenegildo C, Novella S. Journal of Physiology and Biochemistry. 2023 May;79(2):251-260. doi: 10.1007/s13105-022-00935-z. PMID: 36464762

Circulating miRNA fingerprint and endothelial function in myocardial infarction: comparison at acute event and one-year follow-up. Mompeon A, Perez-Cremades D, Paes A, Sanchis J, Ortega-Paz L, Andrea R, Brugaletta S, Sabate M, Novella S, Dantas A, Hermenegildo C. Cells. 2022 Jun 2;11(11):1823. doi: 10.3390/cells11111823. PMID: 35681518

Extracellular histones activate endothelial NLRP3 inflammasome and are associated with a severe sepsis phenotype. Beltrán-García J, Osca-Verdegal R, Pérez-Cremades D, Novella S, Hermenegildo C, Pallardó FV, García-Giménez JL. Journal of Inflammation Research. 2022 Jul 25;15:4217-4238. doi: 10.2147/JIR.S363693. PMID: 35915852

Histone citrullination mediates a protective role in endothelium and modulates inflammation. Osca-Verdegal R, Beltran-Garcia J, Paes A, Nacher-Sendra E, Novella S, Hermenegildo C, Carbonell N, Garcia-Gimenez J, Pallardo F. Cells. 2022 Dec 15;11(24):4070. doi: 10.3390/cells11244070. PMID: 36552833

Regulatory network analysis in estradiol-treated human endothelial cells. Perez-Cremades D, Paes A, Vidal-Gomez X, Mompeon A, Hermenegildo C, Novella S. International Journal of Molecular Sciences. 2021 Jul 30;22(15):8193. doi: 10.3390/ijms22158193. PMID: 34360960

Reference: PI22/01083
Title: Mecanismos moleculares de las rutas de señalización de los miRNA modificados por infarto agudo de miocardio. Influencia del sexo y el envejecimiento.
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Suanna Novella del Campo, Carlos Hermenegildo Caudevilla
Duration: 2023 – 2025
Total budget: 111.320,00 €
Reference: AICO/2021/211
Title: Análisis funcional de las rutas de señalización vascular reguladas por miRNA sensibles a estrógenos
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Susana Novella del Campo, Carlos Hermenegildo Caudevilla
Duration: 2022 – 2024
Total budget: 90.000 €
Reference: PI19/01714
Title: Regulación dependiente de sexo y estrógenos en el síndrome coronario agudo e impacto funcional en  células endoteliales humanas. Nuevos biomarcadores para prevención primaria
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Carlos Hermenegildo Caudevilla, Susana Novella Del Campo
Duration: 2020 – 2023
Total budget: 159.720 €
Reference: PI16/00229
Title: Perfil plasmático de miRNA en infarto agudo de miocardio: relación con la evolución clínica en pacientes y con la función cardiovascular y posible terapia con micropartículas en ratones
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Carlos Hermenegildo Caudevilla
Duration: 2017 – 2020
Total budget: 134.915 €
+ Info
Title: Análisis de la expresión de mirna circulantes en pacientes con infarto agudo de miocardio y su relación con citoquinas. Repercusión funcional en cultivos de células endoteliales humanas
Doctoral candidate: Mompeón Campos, Ana
Director(s): Hermenegildo Caudevilla, Carlos; Novella Del Campo, Susana
Date of the defense: 04/03/2019
University: Universitat de València