Research Group on Maternal Fetal Communication

Reproductive Medicine Area

Project origin of diseases: functional capacity of miRNAs secreted into endometrial fluid in obese and type 2 diabetic patients to determine if they are capable of modifying mouse embryos transcriptomically and/or epigeneticallyProject Transcriptomic and epigenetic modifications in human embryos: obtain the target genes of miRNA miR-30d in human embryos to have a list of regions potentially susceptible to methylation. These regions will be used to design the PCRs of the bisulfite regions by miSeq sequencing

Project Function of DNA and RNA contained in extracellular vesicles secreted by the human endometrium on the pre-implantation embryo: it has been described that the endometrial fluid is secreted by a series of populations of extracellular vesicles (apoptotic bodies, microvesicles and exosomes) that represent a conveyance. We propose that these vesicles contain biomolecules of different natures, specifically focusing on the different types of RNAs and DNA, and that their composition in these chemical species varies throughout the menstrual cycle and depending on the subpopulation of vesicles that is analyzed

Dr. Felip Vilella Mitjana
Dr. Felip Vilella Mitjana

Leading, R4

Felip Vilella Mitjana    

Established, R3

Francisco Raga Baixauli

Recognised/Emerging, R2

Javier Moncayo Arlandi

First Stage, R1

Javier González Fernández

Collaborating Researchers

Ana Ochando Hernández
Sofía Zaragozano Martinez
Neus Puig López

Administrative assistant
The human periconceptional maternal-embryonic space in health and disease. Moreno I, Capalbo A, Mas A, Garrido-Gomez T, Roson B, Poli M, Dimitriadis E, Santamaria X, Vilella F, Simon C. Physiological Reviews. 2023 Feb 16. doi: 10.1152/physrev.00050.2021. PMID: 36796099

The role of extracellular vesicles in intercellular communication in human reproduction. Gonzalez Fernandez J, Moncayo Arlandi J, Ochando A, Simon C, Vilella F. Clinical Science. 2023 Feb 14;137(3):281-301. doi: 10.1042/CS20220793. PMID: 36762584

Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Moreno I, Garcia-Grau I, Perez-Villaroya D, Gonzalez-Monfort M, Bahceci M, Barrionuevo MJ, Taguchi S, Puente E, Dimattina M, Lim MW, Meneghini G, Aubuchon M, Leondires M, Izquierdo A, Perez-Olgiati M, Chavez A, Seethram K, Bau D, Gomez C, Valbuena D, Vilella F, Simon C. Microbiome. 2022 Jan 4;10(1):1. doi: 10.1186/s40168-021-01184-w. PMID: 34980280

Single-cell RNA Sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium. Vilella F, Wang W, Moreno I, Roson B, Quake S, Simon C. Human Reproduction. 2021 Sep 18;36(10):2709-2719. doi: 10.1093/humrep/deab183. PMID: 34329437

Understanding the human endometrium in the 21st century. Vilella F, Wang W, Moreno I, Quake SR, Simon C. American Journal of Obstetrics and Gynecology. 2021 Jul;225(1):1-2. doi: 10.1016/j.ajog.2021.04.224. PMID: 34023092

Endometrial liquid biopsy provides a miRNA roadmap of the secretory phase of the human endometrium. Grasso A, Navarro R, Balaguer Cuenca N, Moreno Gimeno I, Alama P, Jimenez J, Simon Valles C, Vilella Mitjana F. Journal of Clinical Endocrinology & Metabolism. 2020 Mar 1;105(3):dgz146. doi: 10.1210/clinem/dgz146. PMID: 31665361

Identification and Characterization of Extracellular Vesicles and Its DNA Cargo Secreted During Murine Embryo Development. Simon B, Bolumar Recuero D, Amadoz A, Jiménez Almazán J, Valbuena Parilla D, Vilella Mitjana F, Moreno Gimeno I. Genes. 2020 Feb 17;11(2):203. doi: 10.3390/genes11020203. PMID: 32079252

Mother and Embryo Cross-Communication. Idelevich A, Vilella Mitjana F. Genes. 2020 Mar 31;11(4):376. doi: 10.3390/genes11040376. PMID: 32244282

Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle. Wang W, Vilella Mitjana F, Alama P, MORENO GIMENO I, Mignardi M, Isakova A, Pan W, Simon Valles C, Quake S. Nature Medicine. 2020 Oct;26(10):1644-1653. doi: 10.1038/s41591-020-1040-z. PMID: 32929266

The first glimpse of the endometrial microbiota in early pregnancy. Moreno Gimeno I, Garcia I, Bau D, Perez-Villaroya D, Gonzalez-Monfort M, Vilella Mitjana F, Romero R, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Apr;222(4):296-305. doi: 10.1016/j.ajog.2020.01.031. PMID: 32057732

Use of Customizable Nucleases for Gene Editing and Other Novel Applications. Reddy P, Vilella Mitjana F, Izpisua Belmonte J, Simon Valles C. Genes. 2020 Aug 22;11(9):976. doi: 10.3390/genes11090976. PMID: 32842577

Reference: PI21/00528
Title: Caracterización transcriptómica de la implantación embrionaria humana a nivel de célula única usando un endometrio 3D en un chip de microfluidica
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Vilella Mitjana
Duration: 2022 – 2024
Total budget: 90.750 €
Reference: 874867 – HUTER
Title: Human Uterus Cell Atlas
Funding body: European Commission
Principal Investigator: Carlos Simón Vallés
Duration: 2020 – 2022
Total budget: 4.118.943 €
Reference: PI18/00957
Title: Función del ADN y ARN contenido en vesiculas extracelulares secretadas por el endometrio humano sobre el embrion pre-implantatorio
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felip Vilella Mitjana
Duration: 2019 – 2022
Total budget: 135.520 €
+ Info
Title: Extracellular vesicles in the human maternal-embryo crosstalk during the preconception period
Doctoral candidate: Bolumar Recuero, David
Director(s): Simón Vallés, Carlos; Vilella Mitjana, Felipe
Date of the defense: 21/12/2020
University: Universitat de València

Title: Epigenetic analysis of cell-free dna as a tool to study pathogenesis and maternal syndrome of preeclampsia
Doctoral candidate: Corachán García, Irene
Director(s): Simón Vallés, Carlos; Díez Juan, Antonio; Vilella Mitjana, Felipe
Date of the defense: 14/02/2020
University: Universitat de València

Title: Maternal-fetal crosstalk. Elucitaing the role of mir30d in endometrial receptivity and pregnancy outcome
Doctoral candidate: Balaguer Cuenca, Nuria
Director(s): Vilella Mitjana, Felipe; Simón Vallés, Carlos
Date of the defense: 14/01/2019
University: Universitat de València