Dr. Felip Vilella Mitjana

Principal Investigator
Research Group on Maternal Fetal Communication


Dr. Vilella studied Biological Sciences at the Faculty of Biology of the University of Navarra (2002) and two years later obtained a degree in Biochemistry. He obtained his PhD in Molecular Biology at the Faculty of Medicine of the University of Lleida with the qualification of outstanding “cum laude” in 2006.

He made his first post-doctoral stay in the laboratory of Professor Aragón at the Clinical Science Centre of the Medical Research Council (MRC) in London (Marie Curie fellowship). In 2007 he was awarded a grant from the Spanish Ministry of Education and Science (FECYT) for the training of Spanish PhDs abroad. During this period, he specialized in DNA repair mechanisms and cell cycle progression in eukaryotic cells, which gave her the opportunity to carry out a second stay in the laboratory of Professor Lako (a joint unit created between the University of Newcastle and the Príncipe Felipe Research Center in Valencia).

In 2011 he started his career as principal investigator at the IVI Foundation directed by Professor Simón. His main scientific interest focuses on the study of endometrial receptivity and the dialogue that exists between the mother and the embryo during implantation. In 2014 he obtained a Miguel Servet position and joined the INCLIVA Health Research Institute.

He has 42 scientific publications, in prestigious journals such as Nature Medicine, Nature Cell Biology, Development, Endocrine Reviews and Journal of Clinical Endocrinology and Metabolism among others. He is a regular collaborator and reviewer of prestigious international journals. He has supervised 6 doctoral theses. He has participated in more than 16 international projects being principal investigator in 11 of them.

Dr. Felip Vilella Mitjana
Dr. Felip Vilella Mitjana


Decoding the endometrial niche of Asherman’s Syndrome at single-cell resolution. Santamaria X, Roson B, Perez-Moraga R, Venkatesan N, Pardo-Figuerez M, Gonzalez-Fernandez J, Llera-Oyola J, Fernandez E, Moreno I, Salumets A, Vankelecom H, Vilella F, Simon C. Nature Communications. 2023 Sep 21;14(1):5890. doi: 10.1038/s41467-023-41656-1. PMID: 37735465

The human periconceptional maternal-embryonic space in health and disease. Moreno I, Capalbo A, Mas A, Garrido-Gomez T, Roson B, Poli M, Dimitriadis E, Santamaria X, Vilella F, Simon C. Physiological Reviews. 2023 Jul 1;103(3):1965-2038. doi: 10.1152/physrev.00050.2021. PMID: 36796099

The role of extracellular vesicles in intercellular communication in human reproduction. Gonzalez Fernandez J, Moncayo Arlandi J, Ochando A, Simon C, Vilella F. Clinical Science. 2023 Feb 14;137(3):281-301. doi: 10.1042/CS20220793. PMID: 36762584

Vertical transmission of maternal DNA through extracellular vesicles associates with altered embryo bioenergetics during the periconception period. Bolumar D, Moncayo-Arlandi J, Gonzalez-Fernandez J, Ochando A, Moreno I, Monteagudo-Sanchez A, Marin C, Diez A, Fabra P, Checa M, Espinos J, Gardner D, Simon C, Vilella F. eLife. 2023 Dec 27:12:RP88008. doi: 10.7554/eLife.88008. PMID: 38149847

Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Moreno I, Garcia-Grau I, Perez-Villaroya D, Gonzalez-Monfort M, Bahceci M, Barrionuevo MJ, Taguchi S, Puente E, Dimattina M, Lim MW, Meneghini G, Aubuchon M, Leondires M, Izquierdo A, Perez-Olgiati M, Chavez A, Seethram K, Bau D, Gomez C, Valbuena D, Vilella F, Simon C. Microbiome. 2022 Jan 4;10(1):1. doi: 10.1186/s40168-021-01184-w. PMID: 34980280

Single-cell RNA Sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium. Vilella F, Wang W, Moreno I, Roson B, Quake S, Simon C. Human Reproduction. 2021 Sep 18;36(10):2709-2719. doi: 10.1093/humrep/deab183. PMID: 34329437

Understanding the human endometrium in the 21st century. Vilella F, Wang W, Moreno I, Quake SR, Simon C. American Journal of Obstetrics and Gynecology. 2021 Jul;225(1):1-2. doi: 10.1016/j.ajog.2021.04.224. PMID: 34023092

Reference: PI21/00528
Title: Caracterización transcriptómica de la implantación embrionaria humana a nivel de célula única usando un endometrio 3D en un chip de microfluidica
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Vilella Mitjana
Duration: 2022 – 2024
Total budget: 90.750 €
Reference: 874867 – HUTER
Title: Human Uterus Cell Atlas
Funding body: European Commission
Principal Investigator: Carlos Simón Vallés
Duration: 2020 – 2022
Total budget: 4.118.943 €
Reference: PI18/00957
Title: Función del ADN y ARN contenido en vesiculas extracelulares secretadas por el endometrio humano sobre el embrion pre-implantatorio
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felip Vilella Mitjana
Duration: 2019 – 2022
Total budget: 135.520 €
+ Info
Title: Extracellular vesicles in the human maternal-embryo crosstalk during the preconception period
Doctoral candidate: Bolumar Recuero, David
Director(s): Simón Vallés, Carlos; Vilella Mitjana, Felipe
Date of the defense: 21/12/2020
University: Universitat de València

Title: Epigenetic analysis of cell-free dna as a tool to study pathogenesis and maternal syndrome of preeclampsia
Doctoral candidate: Corachán García, Irene
Director(s): Simón Vallés, Carlos; Díez Juan, Antonio; Vilella Mitjana, Felipe
Date of the defense: 14/02/2020
University: Universitat de València

Title: Maternal-fetal crosstalk. Elucitaing the role of mir30d in endometrial receptivity and pregnancy outcome
Doctoral candidate: Balaguer Cuenca, Nuria
Director(s): Vilella Mitjana, Felipe; Simón Vallés, Carlos
Date of the defense: 14/01/2019
University: Universitat de València