Research Group on Breast Cancer Biology

Oncology Area


Resistance to treatments:

  • Evaluation of the recent insights into the development of preclinical trastuzumab-resistant HER2+ breast cancer models.

Metastatic setting:

  • Multicenter phase II study of lurbinectedin in BRCA-mutated and unselected metastatic advanced breast cancer and biomarker assessment substudy.
  • Analysis of postmastectomy radiation therapy in women with T1-T2 tumors and 1 to 3 positive lymph nodes.

ER+ breast cancer:

  • Evaluation of the outcomes of single versus double hormone receptor-positive breast cancer.
  • Description that the ER+ breast cancers resistant to prolonged neoadjuvant letrozole exhibit an E2F4 transcriptional program sensitive to CDK4/6 inhibitors.
  • Design of adjuvant endocrine therapy for premenopausal breast cancer.

Breast cancer in very young women:

  • Identification of miR124-2 as a survival biomarker by methylation deregulation of its promoters.
  • Review of breast cancer in pregnant patients.

Prognostic and prediction:

  • Prognostic role for the derived neutrophil-to-lymphocyte ratio in early breast cancer.
  • Evaluation of the pathologic complete response rate to neoadjuvant chemotherapy in triple negative breast cancer subtypes.
  • Study of the incidence, characteristics, and prevention of the alopecia following adjuvant docetaxel.

Dra. Ana Lluch Hernández
Coordinator
Dra. Ana Lluch Hernández
ana.lluch@uv.es

Dra. Ana Lluch Hernández
Coordinator
Dra. Pilar Eroles Asensio
pilar.eroles@uv.es

RESEARCHERS
Leading, R4

Ana Lluch Hernández    
Pilar Eroles Asensio    

Established, R3

Octavio Burgues Gasión
Isabel Chirivella González

Recognised/Emerging, R2

Begoña Bermejo De Las Heras
Diego Soriano Mena
Elvira Buch Villa
Iris Garrido Cano
Juan Miguel Cejalvo Andújar
Lidia González Villena
Mª Teresa Martínez Martínez

First Stage, R1

Cristina Hernando Meliá
Ana María Ágreda Roca
Ana Caterina Trigo Lameirinhas
Sandra Torres Ruiz

STAFF
Collaborating Researchers

Esther Jordá Sorolla

Nurse

Cristina Tébar Sánchez
Sara Rodríguez Pestano
Silvia Coret Sinisterra

Technicians

Elisa Alonso Yuste
Julia Soler Flores

Administrative assistant

Yolanda De La Cruz Robles

Publications
Adjuvant endocrine therapy in premenopausal breast cancer: 12-year results from SOFT. Francis P, Fleming G, Lang I, Ciruelos E, Bonnefoi H, Bellet M, Bernardo A, Climent M, Martino S, Bermejo B, Burstein H, Davidson N, Geyer C, Walley B, Ingle J, Coleman R, Muller B, Le Du F, Loibl S, Winer E, Ruepp B, Loi S, Colleoni M, Coates A, Gelber R, Goldhirsch A, Regan M. Journal of Clinical Oncology. 2023 Mar 1;41(7):1370-1375. doi: 10.1200/JCO.22.01065. PMID: 36493334

Author Correction: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer. Schettini F, Chic N, Brasó-Maristany F, Paré L, Pascual T, Conte B, Martínez-Sáez O, Adamo B, Vidal M, Barnadas E, Fernández-Martinez A, González-Farre B, Sanfeliu E, Cejalvo JM, Perrone G, Sabarese G, Zalfa F, Peg V, Fasani R, Villagrasa P, Gavilá J, Barrios CH, Lluch A, Martín M, Locci M, De Placido S, Prat A. NPJ Breast Cancer. 2023 Apr 29;9(1):32. doi: 10.1038/s41523-023-00538-x. Erratum for: NPJ Breast Cancer. 2021 Jan 4;7(1):1. PMID: 37120452

CCNE1 and PLK1 mediates resistance to palbociclib in HR+/HER2- metastatic breast cancer. Guerrero-Zotano Á, Belli S, Zielinski C, Gil-Gil M, Fernandez-Serra A, Ruiz-Borrego M, Ciruelos Gil EM, Pascual J, Muñoz-Mateu M, Bermejo B, Margeli Vila M, Antón A, Murillo L, Nisenbaum B, Liu Y, Herranz J, Fernandez Garcia D, Caballero R, López-Guerrero JA, Bianco R, Formisano L, Turner N, Martín M. Clinical Cancer Research. 2023 Apr 14;29(8):1557-1568. doi: 10.1158/1078-0432.CCR-22-2206. PMID: 36749874.

Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells. Oltra S, Colomo S, Sin L, Perez-Lopez M, Lazaro S, Molina-Crespo A, Choi K, Ros-Pardo D, Martinez L, Morales S, Gonzalez-Paramos C, Orantes A, Soriano M, Hernandez A, Lluch A, Rojo F, Albanell J, Gomez-Puertas P, Ko J, Sarrio D, Moreno-Bueno G. Cell Death and Differentiation. 2023 May;30(5):1366-1381. doi: 10.1038/s41418-023-01143-y. PMID: 36899106

Dual neoadjuvant blockade plus chemotherapy versus monotherapy for the treatment of women with non-metastatic HER2-positive breast cancer: a systematic review and meta-analysis. Vazquez J, Antolin S, Ruiz-Borrego M, Servitja S, Alba E, Barnadas A, Lluch A, Martin M, Rodriguez-Lescure A, Sola I, Bonfill X, Urrutia G, Sanchez-Rovira P. Clinical & Translational Oncology. 2022 Nov 22. doi: 10.1007/s12094-022-02998-2. PMID: 36417083

High VEGFR3 expression reduces doxorubicin efficacy in triple-negative breast cancer. Torres Ruiz S, Tormo E, Garrido Cano I, Lameirinhas A, Rojo F, Madoz Gurpide J, Burgues O, Hernando C, Bermejo B, Martinez MT, Lluch A, Cejalvo JM, Eroles P. International Journal of Molecular Sciences. 2023 Feb 10;24(4):3601. doi: 10.3390/ijms24043601. PMID: 36835014

Impact of concurrent tumour events on the prostate cancer outcomes of germline BRCA2 mutation carriers. Lozano R, Castro E, Lopez-Campos F, Thorne H, Ramirez-Backhaus M, Aragon I, Cendon-Florez Y, Gutierrez-Pecharroman A, Salles D, Romero-Laorden N, Lorente D, Gonzalez-Peramato P, Calatrava A, Alonso C, Anido U, Arevalo-Lobera S, Balmana J, Chirivella I, Juan-Fita M, Llort G, Y Cajal T, Almagro E, Alameda D, Lopez-Casas P, Herrera B, Mateo J, Pritchard C, Antonarakis E, Lotan T, Rubio-Briones J, Sandhu S, Olmos D. European Journal of Cancer. 2023 Mar 5;185:105-118. doi: 10.1016/j.ejca.2023.02.022. PMID: 36972661

In the Literature: january 2023. Martin-Arana J, Gambardella V, Tarazona N, Cejalvo JM, Cervantes A. ESMO Open. 2023 Jan 3;8(1):100763. doi: 10.1016/j.esmoop.2022.100763. PMID: 36603523

In the literature: May 2023. Gambardella V, Cejalvo J, Cervantes A. ESMO Open. 2023 May 15;8(3):101562. doi: 10.1016/j.esmoop.2023.101562. PMID: 37196398

miR-146a-5p promotes angiogenesis and confers trastuzumab resistance in HER2+ breast cancer. Cabello P, Torres-Ruiz S, Adam-Artigues A, Fores-Martos J, Martinez M, Hernando C, Zazo S, Madoz-Gurpide J, Rovira A, Burgues O, Rojo F, Albanell J, Lluch A, Bermejo B, Cejalvo J, Eroles P. Cancers. 2023 Apr 4;15(7):2138. doi: 10.3390/cancers15072138. PMID: 37046799

Nodal positivity and systemic therapy among patients with clinical T1-T2N0 human epidermal growth factor receptor-positive breast cancer: Results from two international cohorts. Weiss A, Martinez-Saez O, Waks A, Laws A, McGrath M, Tarantino P, Portnow L, Winer E, Rey M, Tapia M, Prat A, Partridge A, Tolaney S, Cejalvo J, Mittendorf E, King T. Cancer. 2023 Jun 15;129(12):1836-1845. doi: 10.1002/cncr.34750. PMID: 36951169

Palbociclib rechallenge for hormone receptor-positive/HER-negative advanced breast cancer: findings from the phase II BioPER Trial. Albanell J, Perez-Garcia JM, Gil-Gil M, Curigliano G, Ruiz-Borrego M, Comerma L, Gibert J, Bellet M, Bermejo B, Calvo L, de la Haba J, Espinosa E, Minisini AM, Quiroga V, Santaballa Bertran A, Mina L, Bellosillo B, Rojo F, Menendez S, Sampayo-Cordero M, Popa C, Malfettone A, Cortes J, Llombart-Cussac A. Clinical Cancer Research. 2023 Jan 4;29(1):67-80. doi: 10.1158/1078-0432.CCR-22-1281. PMID: 36165912

Physicians’ attitudes and perceived barriers to adherence to the national breast cancer clinical practice guidelines in Mexico: a survey study. Martinez-Cannon B, Soto-Perez-de-Celis E, Valle-Solis A, Arce-Salinas C, Bargallo-Rocha E, Bautista-Pina V, Cervantes-Sanchez G, Flores-Balcazar C, Tamburrino M, Lluch A, Maffuz-Aziz A, Perez-Sanchez V, Poitevin-Chacon A, Salas-Gonzalez E, Torres L, Valero V, Villasenor-Navarro Y, Cardenas-Sanchez J. Clinical & Translational Oncology. 2023 Jan;25(1):151-159. doi: 10.1007/s12094-022-02921-9. PMID: 35986133

Prophylactic mastectomy and bilateral salpingo-oophorectomy in patients with breast cancer: a systematic review of postsurgical sexual function and menopausal hormone therapy symptom mitigation. Morgan O, Belda R, Schnur J, Montgomery G, Parmar S, Chirivella I, Cano A. Sexual Medicine Reviews. 2023 May 14;qead020. doi: 10.1093/sxmrev/qead020. PMID: 37183167

SEOM clinical guideline on heritable TP53-related cancer syndrome (2022). Sanchez-Heras A, Cajal T, Pineda M, Aguirre E, Grana B, Chirivella I, Balmana J, Brunet J. Clinical & Translational Oncology. 2023 May 3. doi: 10.1007/s12094-023-03202-9. PMID: 37133731

The value of sentinel lymph-node biopsy in women with node-positive breast cancer at diagnosis and node-negative tumour after neoadjuvant therapy: a systematic review. Vazquez JC, Pinero A, de Castro FJ, Lluch A, Martin M, Barnadas A, Alba E, Rodriguez-Lescure A, Rojo F, Gimenez J, Sola I, Quintana MJ, Bonfill X, Urrutia G, Sanchez-Rovira P. Clinical & Translational Oncology. 2023 Feb;25(2):417-428. doi: 10.1007/s12094-022-02953-1. PMID: 36153763

Trastuzumab deruxtecan in patients with central nervous system involvement from HER2-positive breast cancer: The DEBBRAH Trial. Perez-Garcia J, Batista M, Cortez P, Ruiz-Borrego M, Cejalvo J, de la Haba-Rodriguez J, Garrigos L, Racca F, Servitja S, Blanch S, Gion M, Nave M, Fernandez-Abad M, Martinez-Bueno A, Llombart-Cussac A, Sampayo-Cordero M, Malfettone A, Cortes J, Braga S. Neuro-Oncology. 2023 Jan 5;25(1):157-166. doi: 10.1093/neuonc/noac144. PMID: 35639825

Triple negative PAM50 non-basal breast cancer subtype predicts benefit from extended adjuvant capecitabine. Asleh K, Lluch A, Goytain A, Barrios C, Wang X, Torrecillas L, Gao D, Ruiz-Borrego M, Leung S, Bines J, Guerrero-Zotano A, Garcia-Saenz J, Cejalvo J, Herranz J, Torres R, de la Haba-Rodriguez J, Ayala F, Gomez H, Rojo F, Nielsen T, Martin M. Clinical Cancer Research. 2023 Jan 17;29(2):389-400. doi: 10.1158/1078-0432.CCR-22-2191. PMID: 36346687

Antagonists of the Mu-opioid receptor in the cancer patient: fact or fiction?. Belltall A, Mazzinari G, Diaz-Cambronero O, Eroles P, Navarro M. Current Oncology Reports. 2022 Oct;24(10):1337-1349. doi: 10.1007/s11912-022-01295-z. PMID: 35648340

CIP2A as a key regulator for AKT phosphorylation has partial impact determining clinical outcome in breast cancer. Luque M, Cristobal I, Sanz-Alvarez M, Santos A, Zazo S, Eroles P, Arpi O, Rovira A, Albanell J, Madoz-Gurpide J, Garcia-Foncillas J, Rojo F. Journal of Clinical Medicine. 2022 Mar 14;11(6):1610. doi: 10.3390/jcm11061610. PMID: 35329936

Clinical and sociodemographic determinants of adherence to World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations in breast cancer survivors-health-EpiGEICAM Study. Lope V, Guerrero-Zotano A, Ruiz-Moreno E, Bermejo B, Antolin S, Montano A, Baena-Canada JM, Ramos Vazquez M, Fernandez de Larrea-Baz N, Chacon JI, Garcia-Saenz JA, Olier C, Munoz M, Anton A, Sanchez Rovira P, Arcusa Lanza A, Gonzalez S, Oltra A, Brunet J, Gavila Gregori J, Martinez MT, Calvo L, Rosell L, Bezares S, Pastor-Barriuso R, Perez-Gomez B, Martin M, Pollan M. Cancers. 2022 Sep 27;14(19):4705. doi: 10.3390/cancers14194705. PMID: 36230628

Clinical factors associated with long-term benefit in patients with metastatic renal cell carcinoma treated with axitinib: real-world AXILONG Study. Pinto A, Reig O, Iglesias C, Gallardo E, Garcia-Del Muro X, Alonso T, Anguera G, Suarez C, Munoz-Langa J, Villalobos-Leon L, Rodriguez-Sanchez A, Lainez N, Martinez-Ortega E, Campayo M, Velastegui A, Rodriguez-Vida A, Villa-Guzman J, Mendez-Vidal M, Rubio G, Garcia I, Capdevila L, Lambea J, Vazquez S, Fernandez O, Hernando-Polo S, Cerezo S, Santander C, Garcia-Marrero R, Zambrana F, Gonzalez-Del Alba A, Lazaro-Quintela M, Castellano D, Chirivella I, Anido U, Viana A, Garcia A, Sotelo M, Arevalo M, Garcia-Donas J, Hernandez C, Bolos M, Llinares J, Climent M. Clinical Genitourinary Cancer. 2022 Feb;20(1):25-34. doi: 10.1016/j.clgc.2021.09.006. PMID: 34789409

Derived neutrophil-to-lymphocyte ratio predicts pathological complete response to neoadjuvant chemotherapy in breast cancer. Ocana A, Chacon J, Calvo L, Anton A, Mansutti M, Albanell J, Martinez M, Lahuerta A, Bisagni G, Bermejo B, Semiglazov V, Thill M, Chan A, Morales S, Herranz J, Tusquets I, Chiesa M, Caballero R, Valagussa P, Bianchini G, Alba E, Gianni L. Frontiers in Oncology. 2022 Feb 11;11:827625. doi: 10.3389/fonc.2021.827625. PMID: 35223459

Development of a Novel NGS methodology for ultrasensitive circulating tumor dna detection as a tool for early-stage breast cancer diagnosis. Jimenez-Rodriguez B, Alba-Bernal A, Lopez-Lopez E, Quiros-Ortega ME, Carbajosa G, Garrido-Aranda A, Alvarez M, Godoy-Ortiz A, Queipo-Ortuno MI, Vicioso L, Diaz-Cordoba G, Roldan-Diaz MD, Velasco-Suelto J, Hernando C, Bermejo B, Julve-Parreno A, Lluch A, Pascual J, Comino-Mendez I, Alba E. International Journal of Molecular Sciences. 2022 Dec 21;24(1):146. doi: 10.3390/ijms24010146. PMID: 36613590

Functional mapping of AKT signaling and biomarkers of response from the FAIRLANE Trial of neoadjuvant ipatasertib plus paclitaxel for triple-negative breast cancer. Shi Z, Wulfkuhle J, Nowicka M, Gallagher RI, Saura C, Nuciforo PG, Calvo I, Andersen J, Passos Coelho JL, Gil Gil MJ, Bermejo B, Pratt DA, Ciruelos EM, Villagrasa P, Wongchenko MJ, Petricoin EF, Oliveira M, Isakoff SJ. Clinical Cancer Research. 2022 Mar 1;28(5):993-1003. doi: 10.1158/1078-0432.CCR-21-2498. PMID: 34907082

Histological grade and tumor stage are correlated with expression of receptor activator of nuclear factor Kappa b (Rank) in epithelial ovarian cancers. Gomez R, Tejada M, Rodriguez-Garcia V, Burgues O, Santos-Llamas A, Martinez-Massa A, Marin-Montes A, Tarin J, Cano A. International Journal of Molecular Sciences. 2022 Feb 3;23(3):1742. doi: 10.3390/ijms23031742. PMID: 35163671

Immunological landscape of HER-2 positive breast cancer. Moragon S, Hernando C, Martinez-Martinez M, Tapia M, Ortega-Morillo B, Lluch A, Bermejo B, Cejalvo J. Cancers. 2022 Jun 28;14(13):3167. doi: 10.3390/cancers14133167. PMID: 35804943

Impact of hormone therapy side effects on health-related quality of life, distress, and well-being of breast cancer survivors. Andreu Y, Soto-Rubio A, Ramos-Campos M, Escriche-Saura A, Martinez M, Gavila J. Scientific Reports. 2022 Nov 4;12(1):18673. doi: 10.1038/s41598-022-22971-x. PMID: 36333362

Impact of the COVID-19 pandemic on a cancer fast-track programme. Martinez M, Moragon S, Ortega-Morillo B, Monton-Bueno J, Simon S, Rosello S, Insa A, Viala A, Navarro J, Sanmartin A, Fluixa C, Julve A, Soriano D, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner M, Cano A, Silvestre A, Teruel A, Bermejo B, Cervantes A, Chirivella Gonzalez I. Cancer Control. 2022 Jan-Dec;29:10732748221131000. doi: 10.1177/10732748221131000. PMID: 36355430

In the literature: February 2022. Gambardella V, Cejalvo JM, Gonzalez Barrallo I, Gimeno Valiente F, Cervantes A. ESMO open. 2022 Feb 23;7(2):100411. doi: 10.1016/j.esmoop.2022.100411. PMID: 35219243

In the literature: November 2022. Gambardella V, Cejalvo J, Cervantes A. ESMO Open. 2022 Nov 17;7(6):100643. doi: 10.1016/j.esmoop.2022.100643. PMID: 36403559

Is axillary assessment of ductal carcinoma in situ of the breast necessary in all cases?. Bellver G, Buch E, Ripoll F, Adrianzen M, Bermejo B, Burgues O, Julve A, Ortega J. Journal of Surgical Research. 2022 Mar;271:145-153. doi: 10.1016/j.jss.2021.10.006. PMID: 34902737

LCOR mediates interferon-independent tumor immunogenicity and responsiveness to immune-checkpoint blockade in triple-negative breast cancer. Perez-Nunez I, Rozalen C, Palomeque J, Sangrador I, Dalmau M, Comerma L, Hernandez-Prat A, Casadevall D, Menendez S, Liu D, Shen M, Berenguer J, Ruiz I, Pena R, Montanes J, Alba M, Bonnin S, Ponomarenko J, Gomis R, Cejalvo J, Servitja S, Marzese D, Morey L, Voorwerk L, Arribas J, Bermejo B, Kok M, Pusztai L, Kang Y, Albanell J, Celia-Terrassa T. Nature Cancer. 2022 Mar;3(3):355-370. doi: 10.1038/s43018-022-00339-4. PMID: 35301507

MicroRNAs as a clue to overcome breast cancer treatment resistance. Garrido-Cano I, Pattanayak B, Adam-Artigues A, Lameirinhas A, Torres-Ruiz S, Tormo E, Cervera R, Eroles P. Cancer Metastasis Reviews. 2022 Mar;41(1):77-105. doi: 10.1007/s10555-021-09992-0. PMID: 34524579

miR-99a-5p modulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from the discovery to in vivo studies. Garrido-Cano I, Adam-Artigues A, Lameirinhas A, Blandez J, Candela-Noguera V, Rojo F, Zazo S, Madoz-Gurpide J, Lluch A, Bermejo B, Sancenon F, Cejalvo J, Martinez-Manez R, Eroles P. Cancer Communications. 2022 Dec;42(12):1412-1416. doi: 10.1002/cac2.12352. PMID: 35997029

mTOR inhibition and trastuzumab-emtansine (T-DM1) in HER2-positive breast cancer. Casadevall D, Hernandez-Prat A, Garc A-Alonso S, Arpi-Llucia O, Menendez S, Qin M, Guardia C, Morancho B, Sanchez-Mart N F, Zazo S, Gavilan E, Sabbaghi M, Eroles P, Cejalvo J, Lluch A, Rojo F, Pandiella A, Rovira A, Albanell J. Molecular Cancer Research. 2022 Jul 6;20(7):1108-1121. doi: 10.1158/1541-7786.MCR-21-0545. PMID: 35348729

Oncolytic viruses: a new immunotherapeutic approach for breast cancer treatment?. Cejalvo JM, Falato C, Villanueva L, Tolosa P, Gonzalez X, Pascal M, Canes J, Gavila J, Manso L, Pascual T, Prat A, Salvador F. Cancer Treatment Reviews. 2022 May;106:102392. doi: 10.1016/j.ctrv.2022.102392. PMID: 35436729

Opioid receptor expression in colorectal cancer: a nested matched case-control study. Belltall A, Mazzinari G, Garrido-Cano I, Giner F, Mari A, Eroles P, Argente-Navarro M, Cata J, Diaz-Cambronero O. Frontiers in Oncology. 2022 Apr 6;12:801714. doi: 10.3389/fonc.2022.801714. PMID: 35463331

Overall survival in the OlympiA phase Ill trial of adjuvant olaparib in patients with germime pathogenic variants in BRCA1/2 and high-risk, early breast cancer. Geyer C, Garber J, Gelber R, Yothers G, Taboada M, Ross L, Rastogi P, Cui K, Arahmani A, Aktan G, Armstrong A, Arnedos M, Balmana J, Bergh J, Bliss J, Delaloge S, Domchek S, Eisen A, Elsafy F, Fein L, Fielding A, Ford J, Friedman S, Gelmon K, Gianni L, Gnant M, Hollingsworth S, Im S, Jager A, Lakhani S, Janni W, Linderholm B, Liu T, Loman N, Korde L, Loibl S, Lucas P, Marme F, de Duenas E, McConnell R, Phillips K, Piccart M, Rossi G, Schmutzler R, Senkus E, Shao Z, Sharma P, Singer C, Spanic T, Stickeler E, Toi M, Traina T, Viale G, Zoppoli G, Park Y, Yerushalmi R, Yang H, Pang D, Jung K, Mailliez A, Fan Z, Tennevet I, Zhang J, Nagy T, Sonke G, Sun Q, Parton M, Colleoni M, Schmidt M, Brufsky A, Razaq W, Kaufman B, Cameron D, Campbell C, Tutt A, Johannsson O. Annals of Oncology. 2022 Dec;33(12):1250-1268. doi: 10.1016/j.annonc.2022.09.159. PMID: 36228963

Overall survival with palbociclib plus endocrine therapy versus capecitabine in postmenopausal patients with hormone receptor-positive, HER2-negative metastatic breast cancer in the PEARL study. Martin M, Zielinski C, Ruiz-Borrego M, Carrasco E, Ciruelos EM, Munoz M, Bermejo B, Margeli M, Csoszi T, Anton A, Turner N, Casas MI, Morales S, Alba E, Calvo L, de la Haba-Rodriguez J, Ramos M, Murillo L, Santaballa A, Alonso-Romero JL, Sanchez-Rovira P, Corsaro M, Huang X, Thallinger C, Kahan Z, Gil-Gil M. European Journal of Cancer. 2022 Jun;168:12-24. doi: 10.1016/j.ejca.2022.03.006. PMID: 35429901

Pathologic complete response (pCR) to neoadjuvant treatment with or without atezolizumab in triple-negative, early high-risk and locally advanced breast cancer: NeoTRIP Michelangelo randomized study. Gianni L, Huang CS, Egle D, Bermejo B, Zamagni C, Thill M, Anton A, Zambelli S, Bianchini G, Russo S, Ciruelos EM, Greil R, Semiglazov V, Colleoni M, Kelly C, Mariani G, Del Mastro L, Maffeis I, Valagussa P, Viale G. Annals of Oncology. 2022 May;33(5):534-543. doi: 10.1016/j.annonc.2022.02.004. PMID: 35182721

Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer. Cortes J, Rugo H, Cescon D, Im S, Yusof M, Gallardo C, Lipatov O, Barrios C, Perez-Garcia J, Iwata H, Masuda N, Otero M, Gokmen E, Loi S, Guo Z, Zhou X, Karantza V, Pan W, Schmid P. New England Journal of Medicine. 2022 Jul 21;387(3):217-226. doi: 10.1056/NEJMoa2202809. PMID: 35857659

Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A. Mouron S, Bueno MJ, Lluch A, Manso L, Calvo I, Cortes J, Garcia-Saenz JA, Gil-Gil M, Martinez-Janez N, Apala JV, Caleiras E, Ximénez-Embún P, Muñoz J, Gonzalez-Cortijo L, Murillo R, Sánchez-Bayona R, Cejalvo JM, Gómez-López G, Fustero-Torre C, Sabroso-Lasa S, Malats N, Martinez M, Moreno A, Megias D, Malumbres M, Colomer R, Quintela-Fandino M. Nature Communications. 2022 Dec 7;13(1):7529. doi: 10.1038/s41467-022-35065-z. PMID: 36477027

Pre-operative ribociclib plus letrozole versus chemotherapy: Health-related quality of life outcomes from the SOLTI CORALLEEN trial. Villacampa G, Falato C, Pare L, Hernando C, Arumi M, Saura C, Gomez G, Munoz M, Gil-Gil M, Izarzugaza Y, Ferrer N, Najera-Zuloaga J, Montano A, Ciruelos E, Gonzalez-Santiago S, Villagrasa P, Gavila J, Prat A, Pascual T. European Journal of Cancer. 2022 Oct;174:232-242. doi: 10.1016/j.ejca.2022.07.028. PMID: 36067616

Randomized phase II study of fulvestrant plus palbociclib or placebo in endocrine-sensitive, hormone receptor-positive/HER2-advanced breast cancer: GEICAM/2014-12 (FLIPPER). Albanell J, Martinez M, Ramos M, O’Connor M, de la Cruz-Merino L, Santaballa A, Martinez-Janez N, Moreno F, Fernandez I, Alarcon J, Virizuela J, de la Haba-Rodriguez J, Sanchez-Rovira P, Gonzalez-Cortijo L, Margeli M, Sanchez-Munoz A, Anton A, Casas M, Bezares S, Rojo F. European Journal of Cancer. 2022 Jan;161:26-37. doi: 10.1016/j.ejca.2021.11.010. PMID: 34902765

Referral criteria to clinical genetics from primary care: consensus document. Ejarque Domenech I, Marin Reina P, Garcia-Minaur Rica S, Chirivella Gonzalez I, Martinez Martinez M, Garcia Rodriguez A, Alvarez de Andres S, Telleria Orriols J. Atencion Primaria. 2022 Nov 11;54(12):102501. doi: 10.1016/j.aprim.2022.102501. PMID: 36375295

Relationship between nutritional treatment compliance and nutritional status improvements in patients with gastrointestinal impairment taking an oral peptide-based supplement. Lopez-Medina J, Lopez-Rodriguez C, Estornell-Gualde M, Rey-Fernandez L, Gomez-Senent S, Joaquin-Ortiz C, Fernandez-Soto M, Hurtado-Garcia R, Martin-Martin M, Barrera-Martin A, Vitales-Farrero M, Martinez-Ortega A, Blanca-Martinez-Barbeito M, Vazquez-Vizcaino B, Tasende-Fernandez C, Penacho-Lazaro M, Jorda-Sorolla E, Sanchez-Sanchez R, Diaz-Gomez L, Baos-Fernandez S, Guzman-Rolo G, Ballesteros-Pomar M. Nutrition. 2022 Oct;102:111734. doi: 10.1016/j.nut.2022.111734. PMID: 35839658

Role of SALL4 in HER2+breast cancer progression: regulating PI3K/AKT Pathway. Pattanayak B, Lameirinhas A, Torres-Ruiz S, Burgues O, Rovira A, Martinez M, Tapia M, Zazo S, Albanell J, Rojo F, Bermejo B, Eroles P. International Journal of Molecular Sciences. 2022 Oct 31;23(21):13292. doi: 10.3390/ijms232113292. PMID: 36362083

Safety and efficacy of ribociclib plus letrozole in patients with HR+, HER2- advanced breast cancer: results from the Spanish sub-population of the phase 3b CompLEEment-1 trial. Salvador Bofill J, Moreno Anton F, Rodriguez Sanchez CA, Galve Calvo E, Hernando Melia C, Ciruelos Gil EM, Vidal M, Jimenez-Rodriguez B, De la Cruz Merino L, Martinez Janez N, Villanueva Vazquez R, de Toro Salas R, Anton Torres A, Alvarez Lopez IM, Gavila Gregori J, Quiroga Garcia V, Vicente Rubio E, De la Haba-Rodriguez J, Gonzalez-Santiago S, Diaz Fernandez N, Barnadas Molins A, Cantos Sanchez de Ibarguen B, Delgado Mingorance JI, Bellet Ezquerra M, de Casa S, Gimeno A, Martin M. Breast. 2022 Sep 28;66:77-84. doi: 10.1016/j.breast.2022.09.006. PMID: 36206609

Solid tumor opioid receptor expression and oncologic outcomes: analysis of the cancer genome atlas and genotype tissue expression Project. Belltall A, Zuniga-Trejos S, Garrido-Cano I, Eroles P, Argente-Navarro M, Buggy D, Diaz-Cambronero O, Mazzinari G. Frontiers in Oncology. 2022 Mar 10;12:801411. doi: 10.3389/fonc.2022.801411. PMID: 35359418

SOLTI-1904 ACROPOLI TRIAL: efficacy of spartalizumab monotherapy across tumor-types expressing high levels of PD1 mRNA. Prat A, Paz-Ares L, Juan M, Felip E, Garralda E, Gonzalez B, Arance A, Martin-Liberal J, Gavila J, Lopez-Gonzalez A, Miguel Cejalvo J, Izarzugaza Y, Amillano K, Garcia Corbacho J, Saura C, Racca F, Hierro C, Sanfeliu E, Gonzalez X, Canes J, Villacampa G, Salvador F, Pascual T, Mesia R, Cervantes A, Tabernero J. Future Oncology. 2022 Oct 6. doi: 10.2217/fon-2022-0660. PMID: 36200668

Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+breast tumors. Rivas EI, Linares J, Zwick M, Gomez-Llonin A, Guiu M, Labernadie A, Badia-Ramentol J, Llado A, Bardia L, Perez-Nunez I, Martinez-Ciarpaglini C, Tarazona N, Sallent-Aragay A, Garrido M, Celia-Terrassa T, Burgues O, Gomis RR, Albanell J, Calon A. Nature Communications. 2022 Sep 9;13(1):5310. doi: 10.1038/s41467-022-32782-3. PMID: 36085201

Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer. Adam-Artigues A, Arenas E, Martinez-Sabadell A, Braso-Maristany F, Cervera R, Tormo E, Hernando C, Martinez M, Carbonell-Asins J, Simon S, Poveda J, Moragon S, Zazo S, Martinez D, Rovira A, Burgues O, Rojo F, Albanell J, Bermejo B, Lluch A, Prat A, Arribas J, Eroles P, Cejalvo J. Science Advances. 2022 May 20;8(20):eabk2746. doi: 10.1126/sciadv.abk2746. PMID: 35594351

The TRAR gene classifier to predict response to neoadjuvant therapy in HER2-positive and ER-positive breast cancer patients: an explorative analysis from the NeoSphere trial. Triulzi T, Bianchini G, Di Cosimo S, Pienkowski T, Im YH, Valeria Bianchi G, Galbardi B, Dugo M, De Cecco L, Tseng LM, Liu MC, Bermejo B, Semiglazov V, Viale G, de la Haba-Rodriguez J, Oh DY, Poirier B, Valagussa P, Gianni L, Tagliabue E. Molecular Oncology. 2022 Jun;16(12):2355-2366. doi: 10.1002/1878-0261.13141. PMID: 34816585

The value of sentinel lymph-node biopsy after neoadjuvant therapy: an overview. Vazquez J, Pinero A, de Castro F, Lluch A, Martin M, Barnadas A, Alba E, Rodriguez-Lescure A, Rojo F, Gimenez J, Sola I, Quintana M, Bonfill X, Urrutia G, Sanchez-Rovira P. Clinical & Translational Oncology. 2022 Sep;24(9):1744-1754. doi: 10.1007/s12094-022-02824-9. PMID: 35414152

Transcriptional profile associated with clinical outcomes in metastatic hormone-sensitive prostate cancer treated with androgen deprivation and docetaxel. Jimenez N, Reig O, Marin-Aguilera M, Aversa C, Ferrer-Mileo L, Font A, Rodriguez-Vida A, Climent MA, Cros S, Chirivella I, Domenech M, Figols M, Gonzalez-Billalabeitia E, Jimenez Peralta D, Rodriguez-Carunchio L, Garcia-Esteve S, Garcia de Herreros M, Ribal MJ, Prat A, Mellado B. Cancers. 2022 Sep 29;14(19):4757. doi: 10.3390/cancers14194757. PMID: 36230681

Type does matter. Use VIRGIN olive oil as your preferred fat to reduce your risk of breast cancer: case-control EpiGEICAM study. Donat-Vargas C, Guerrero-Zotano A, Lope V, Bermejo B, Casas A, Baena-Canada J, Antolin S, Sanchez-Rovira P, Anton A, Garcia-Saenz J, Ramos M, Munoz M, de Juan A, Sanchez C, Chacon J, Gil-Gil M, Conejero R, Llombart A, Bezares S, de Larrea-Baz N, Perez-Gomez B, Martin M, Pollan M. European Journal of Clinical Nutrition. 2022 Sep;76(9):1343-1346. doi: 10.1038/s41430-022-01101-w. PMID: 35194197

21-Gene assay to inform chemotherapy benefit in node-positive breast cancer. Kalinsky K, Barlow WE, Gralow JR, Meric-Bernstam F, Albain KS, Hayes DF, Lin UN, Perez EA, Goldstein LJ, Chia SKL, Dhesy-Thind S, Rastogi P, Alba E, Delaloge S, Martin M, Kelly CM, Ruiz-Borrego M, Gil-Gil M, Arce-Salinas CH, Brain EGC, Lee ES, Pierga JY, Bermejo B, Ramos-Vazquez M, Jung KH, Ferrero JM, Schott AF, Shak S, Sharma P, Lew DL, Miao J, Tripathy D, Pusztai L, Hortobagyi GN. New England Journal of Medicine. 2021 Dec 16;385(25):2336-2347. doi: 10.1056/NEJMoa2108873. PMID: 34914339

Adjuvant olaparib for patients with BRCA1- or BRCA2-mutated breast cancer. Tutt A, Garber J, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber R, de Azambuja E, Fielding A, Balmana J, Domchek S, Gelmon K, Hollingsworth S, Korde L, Linderholm B, Bandos H, Senkus E, Suga J, Shao Z, Pippas A, Nowecki Z, Huzarski T, Ganz P, Lucas P, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger G, Costantino J, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani S, Yothers G, Campbell C, Geyer C, OlympiA Clinical Trial Steering. New England Journal of Medicine. 2021 Jun 24;384(25):2394-2405. doi: 10.1056/NEJMoa2105215. PMID: 34081848

Anomalous right coronary artery from the left sinus with interarterial course. Marcos Garcés V, Lorenzo Hernández M, Martínez Más M, Parrilla Muñoz C, Pernias Escrig V, Bodí Peris V. Coronary Artery Disease. 2021 Aug 1;32(5):475-477. doi: 10.1097/MCA.0000000000000941. PMID: 32804784

Chemotherapy de-escalation using an F-18-FDG-PET-based pathological response-adapted strategy in patients with HER2-positive early breast cancer (PHERGain): a multicentre, randomised, open-label, non-comparative, phase 2 trial. Manuel Perez-Garcia J, Gebhart G, Ruiz Borrego M, Stradella A, Bermejo B, Schmid P, Marme F, Escriva-de-Romani S, Calvo L, Ribelles N, Martinez N, Albacar C, Prat A, Dalenc F, Kerrou K, Colleoni M, Afonso N, Di Cosimo S, Sampayo-Cordero M, Malfettone A, Cortes J, Llombart-Cussac A. Lancet Oncology. 2021 Jun;22(6):858-871. doi: 10.1016/S1470-2045(21)00122-4. PMID: 34019819

Circadian PERformance in breast cancer: a germline and somatic genetic study of PER3VNTR polymorphisms and gene co-expression. Fores-Martos J, Cervera-Vidal R, Sierra-Roca J, Lozano-Asencio C, Fedele V, Cornelissen S, Edvarsen H, Tadeo-Cervera I, Eroles P, Lluch A, Tabares-Seisdedos R, Falco A, Van’t Veer LJ, Schmidt M, Quigley DA, Borresen-Dale AL, Kristensen VN, Balmain A, Climent J. NPJ Breast Cancer. 2021 Sep 10;7(1):118. doi: 10.1038/s41523-021-00329-2. PMID: 34508103

Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer. Adam-Artigues A, Garrido-Cano I, Simon S, Ortega B, Moragon S, Lameirinhas A, Constancio V, Salta S, Burgues O, Bermejo B, Henrique R, Lluch A, Jeronimo C, Eroles P, Cejalvo J. ESMO Open. 2021 Jan 18;6(1):100039. doi: 10.1016/j.esmoop.2020.100039. PMID: 33477007

Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer. Schettini F, Chic N, Braso-Maristany F, Pare L, Pascual T, Conte B, Martinez-Saez O, Adamo B, Vidal M, Barnadas E, Fernandez-Martinez A, Gonzalez-Farre B, Sanfeliu E, Cejalvo J, Perrone G, Sabarese G, Zalfa F, Peg V, Fasani R, Villagrasa P, Gavila J, Barrios C, Lluch A, Martin M, Locci M, De Placido S, Prat A. NPJ Breast Cancer. 2021 Jan 4;7(1):1. doi: 10.1038/s41523-020-00208-2. PMID: 33397968

Expression of phosphorylated BRD4 is markedly associated with the activation status of the PP2A pathway and shows a strong prognostic value in triple negative breast cancer patients. Sanz-Alvarez M, Cristobal I, Luque M, Santos A, Zazo S, Madoz-Gurpide J, Carames C, Chiang C, Garcia-Foncillas J, Eroles P, Albanell J, Rojo F. Cancers. 2021 Mar 12;13(6):1246. doi: 10.3390/cancers13061246. PMID: 33809005

Fertility and breast cancer: a literature review of counseling, preservation options and outcomes. Moragon S, Di Liello R, Bermejo B, Hernando C, Olcina E, Chirivella I, Lluch A, Cejalvo JM, Martinez MT, Critical Reviews In Oncology/Hematology. 2021 Aug 27;166:103461. doi: 10.1016/j.critrevonc.2021.103461. PMID: 34461268

Final results of the double-blind placebo-controlled randomized phase 2 LOTUS trial of first-line ipatasertib plus paclitaxel for inoperable locally advanced/metastatic triple-negative breast cancer. Dent R, Oliveira M, Isakoff S, Im S, Espie M, Blau S, Tan A, Saura C, Wongchenko M, Xu N, Bradley D, Reilly S, Mani A, Kim S, LOTUS Investigators. Breast Cancer Research and Treatment. 2021 Sep;189(2):377-386. doi: 10.1007/s10549-021-06143-5. PMID: 34264439

First nationwide molecular screening program in Spain for patients with advanced breast cancer: results from the AGATA SOLTI-1301 Study. Pernas S, Villagrasa P, Vivancos A, Scaltriti M, Rodon J, Burgues O, Nuciforo P, Canes J, Pare L, Duenas M, Vidal M, Cejalvo J, Perello A, Llommbard-Cussac A, Dorca J, Montano A, Pascual T, Oliveira M, Ribas G, Rapado I, Prat A, Ciruelos E. Frontiers in Oncology. 2021 Nov 4;11:744112. doi: 10.3389/fonc.2021.744112. PMID: 34804931

Health-related quality of life with palbociclib plus endocrine therapy versus capecitabine in postmenopausal patients with hormone receptor-positive metastatic breast cancer: Patient-reported outcomes in the PEARL study. Kahan Z, Gil-Gil M, Ruiz-Borrego M, Carrasco E, Ciruelos E, Munoz M, Bermejo B, Margeli M, Anton A, Casas M, Csoszi T, Murillo L, Morales S, Calvo L, Lang I, Alba E, de la Haba-Rodriguez J, Ramos M, Lopez I, Gal-Yam E, Garcia-Palomo A, Alvarez E, Gonzalez-Santiago S, Rodriguez C, Servitja S, Corsaro M, Rodrigalvarez G, Zielinski C, Martin M. European journal of cancer. 2021 Aug 20;156:70-82. doi: 10.1016/j.ejca.2021.07.004. PMID: 34425406

Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer. Griguolo G, Serna G, Pascual T, Fasani R, Guardia X, Chic N, Pare L, Pernas S, Munoz M, Oliveira M, Vidal M, Llombart-Cussac A, Cortes J, Galvan P, Bermejo B, Martinez N, Lopez R, Morales S, Garau I, Manso L, Alarcon J, Martinez E, Villagrasa P, Prat A, Nuciforo P. NPJ Precision Oncology. 2021 Mar 19;5(1):23. doi: 10.1038/s41698-021-00163-6. PMID: 33742063

In the literature: April 2021. Martin-Martorell P, Gonzalez-Barrallo I, Gambardella V, Cejalvo J M, Cervantes A. ESMO open. 2021 Apr 19;6(3):100116. doi: 10.1016/j.esmoop.2021.100116. PMID: 33887688

In the literature: August 2021. Gambardella V, Alfaro-Cervello C, Cejalvo J, Tapia M, Cervantes A. ESMO Open. 2021 Aug 16;6(5):100247. doi: 10.1016/j.esmoop.2021.100247. PMID: 34411970

In the literature: February 2021. Cejalvo J, Gambardella V, Fleitas T, Cervantes A. ESMO Open. 2021 Feb 24;6(2):100061. doi: 10.1016/j.esmoop.2021.100061. PMID: 33639602

In the literature: June 2021. Gambardella V, Candia L, Tapia M, Cejalvo JM, Cervantes A. ESMO open. 2021 Jun;6(3):100186. doi: 10.1016/j.esmoop.2021.100186. PMID: 34098228

Interobserver variability in the assessment of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative invasive breast carcinoma influences the association with pathological complete response: the IVITA study. Van Bockstal M, Francois A, Altinay S, Arnould L, Balkenhol M, Broeckx G, Burgues O, Colpaert C, Dedeurwaerdere F, Dessauvagie B, Duwel V, Floris G, Fox S, Gerosa C, Hastir D, Jaffer S, Kurpershoek E, Lacroix-Triki M, Laka A, Lambein K, MacGrogan G, Marchio C, Martinez M, Nofech-Mozes S, Peeters D, Ravarino A, Reisenbichler E, Resetkova E, Sanati S, Schelfhout A, Schelfhout V, Shaaban A, Sinke R, Stanciu-Pop C, van Deurzen C, van de Vijver K, Van Rompuy A, Vincent-Salomon A, Wen H, Wong S, Bouzin C, Galant C. Modern Pathology. 2021 Dec;34(12):2130-2140. doi: 10.1038/s41379-021-00865-z. PMID: 34218258

Molecular profiling of advanced solid tumours. The impact of experimental molecular-matched therapies on cancer patient outcomes in early-phase trials: the MAST study. Gambardella V, Lombardi P, Carbonell-Asins JA, Tarazona N, Cejalvo JM, Gonzalez-Barrallo I, Martin-Arana J, Tebar-Martinez R, Viala A, Bruixola G, Hernando C, Blasco I, Papaccio F, Martinez-Ciarpaglini C, Alfaro-Cervello C, Seda-Garcia E, Blesa S, Chirivella I, Castillo J, Monton-Bueno JV, Rosello S, Huerta M, Perez-Fidalgo A, Martin-Martorell P, Insa-Molla A, Fleitas T, Rentero-Garrido P, Zuniga-Trejos S, Cervantes A, Roda D. British Journal of Cancer. 2021 Oct;125(9):1261-1269. doi: 10.1038/s41416-021-01502-x. PMID: 34493820

Nanoporous Anodic Alumina-Based Sensor for miR-99a-5p Detection as an Effective Early Breast Cancer Diagnostic Tool. Garrido-Cano I, Pla L, Santiago-Felipe S, Simon S, Ortega B, Bermejo B, Lluch A, Cejalvo J, Eroles P, Martinez-Manez R. ACS Sensors. 2021 Mar 26;6(3):1022-1029. doi: 10.1021/acssensors.0c02222. PMID: 33599490

Neoadjuvant eribulin in HER2-negative early-stage breast cancer (SOLTI-1007-NeoEribulin): a multicenter, two-cohort, non-randomized phase II trial. Pascual T, Oliveira M, Villagrasa P, Ortega V, Pare L, Bermejo B, Morales S, Amillano K, Lopez R, Galvan P, Canes J, Salvador F, Nuciforo P, Rubio IT, Llombart-Cussac A, Di Cosimo S, Baselga J, Harbeck N, Prat A, Cortes J. NPJ Breast Cancer. 2021 Nov 25;7(1):145. doi: 10.1038/s41523-021-00351-4. PMID: 34824288

Oral Selective Estrogen Receptor Degraders (SERDs) as a novel breast cancer therapy: present and future from a clinical perspective. Hernando C, Ortega-Morillo B, Tapia M, Moragon S, Martinez M, Eroles P, Garrido-Cano I, Adam-Artigues A, Lluch A, Bermejo B, Cejalvo J. International Journal of Molecular Sciences. 2021 Jul 22;22(15):7812. doi: 10.3390/ijms22157812. PMID: 34360578

Palbociclib in combination with endocrine therapy versus capecitabine in hormonal receptor-positive, human epidermal growth factor 2-negative, aromatase inhibitor-resistant metastatic breast cancer: a phase III randomised controlled trial-PEARL. Martin M, Zielinski C, Ruiz-Borrego M, Carrasco E, Turner N, Ciruelos E, Munoz M, Bermejo B, Margeli M, Anton A, Kahan Z, Csoszi T, Casas M, Murillo L, Morales S, Alba E, Gal-Yam E, Guerrero-Zotano A, Calvo L, Haba-Rodriguez J, Ramos M, Alvarez I, Garcia-Palomo A, Bartlett C, Koehler M, Caballero R, Corsaro M, Huang X, Garcia-Saenz J, Chacon J, Swift C, Thallinger C, Gil-Gil M. Annals of oncology : official journal of the European Society for Medical Oncology. 2021 Apr;32(4):488-499. doi: 10.1016/j.annonc.2020.12.013. PMID: 33385521

Pembrolizumab plus eribulin in hormone-receptor-positive, HER2-negative, locally recurrent or metastatic breast cancer (KELLY): An open-label, multicentre, single-arm, phase Ⅱ trial. Perez-Garcia JM, Llombart-Cussac A, Cortes MG, Curigliano G, Lopez-Miranda E, Alonso JL, Bermejo B, Calvo L, Caranana V, de la Cruz Sanchez S, Vazquez RM, Prat A, Borrego MR, Sampayo-Cordero M, Segui-Palmer MA, Soberino J, Malfettone A, Schmid P, Cortes J. European Journal of Cancer. 2021 May;148:382-394. doi: 10.1016/j.ejca.2021.02.028. PMID: 33794440

Preclinical and clinical characterization of fibroblast-derived neuregulin-1 on trastuzumab and pertuzumab activity in HER2-positive breast cancer. Guardia C, Bianchini G, Arpi-LLucia O, Menendez S, Casadevall D, Galbardi B, Dugo M, Servitja S, Montero J, Soria-Jimenez L, Sabbaghi M, Pena R, Madoz-Gurpide J, Lloveras B, Lluch A, Eroles P, Arribas J, Pandiella A, Gianni L, Rojo F, Rovira A, Albanell J. Clinical Cancer Research. 2021 Sep 15;27(18):5096-5108. doi: 10.1158/1078-0432.CCR-20-2915. PMID:34385295

Predictive and prognostic value of total tumor load in sentinel lymph nodes in breast cancer patients after neoadjuvant treatment using one-step nucleic acid amplification: the NEOVATTL study. Vieites B, Lopez-Garcia M, Martin-Salvago M, Ramirez-Tortosa C, Rezola R, Sancho M, Lopez-Vilaro L, Villardell F, Burgues O, Fernandez-Rodriguez B, Alfaro L, Peg V. Clinical & Translational Oncology. 2021 Jul;23(7):1377-1385. doi: 10.1007/s12094-020-02530-4. PMID: 33517542

Prevalence and clinicopathological characteristics of moderate and high-penetrance genes in non-BRCA1/2 breast cancer high-risk Spanish families. Fonfria M, Jimenez I, Tena I, Chirivella I, Richart-Aznar P, Segura A, Sanchez-Heras A, Martinez-Duenas E. Journal of Personalized Medicine. 2021 Jun 12;11(6):548. doi: 10.3390/jpm11060548. PMID: 34204722

Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer. Smyth LM, Batist G, Meric-Bernstam F, Kabos P, Spanggaard I, Lluch A, Jhaveri K, Varga A, Wong A, Schram AM, Ambrose H, Carr TH, de Bruin EC, Salinas-Souza C, Foxley A, Hauser J, Lindemann JPO, Maudsley R, McEwen R, Moschetta M, Nikolaou M, Schiavon G, Razavi P, Banerji U, Baselga J, Hyman DM, Chandarlapaty S. NPJ Breast Cancer. 2021 Apr 16;7(1):44. doi: 10.1038/s41523-021-00251-7. PMID: 33863913

Sentinel lymph node BIOPSY after neoadjuvant therapy in breast cancer patients with lymph node involvement at diagnosis. Could wire localization of clipped node improve our results?. Alarcon M, Buch E, Julve A, Hernandorena M, Tajahuerce M, Rodriguez H, Bermejo B, Ramirez J, Burgues O, Diaz S, Alcala G, Ortega J. Surgeon. 2021 Dec;19(6):344-350. doi: 10.1016/j.surge.2021.01.013. PMID: 33663946

SOLTI-1805 TOT-HER3 study concept: a window-of-opportunity trial of patritumab deruxtecan, a her3 directed antibody drug conjugate, in patients with early breast cancer. Pascual T, Oliveira M, Ciruelos E, Ezquerra M, Saura C, Gavila J, Pernas S, Munoz M, Vidal M, Vila M, Cejalvo J, Gonzalez-Farre B, Espinosa-Bravo M, Cruz J, Salvador-Bofill F, Guerra J, Barrera A, de Dios M, Esker S, Fan P, Martinez-Saez O, Villacampa G, Pare L, Ferrero-Cafiero J, Villagrasa P, Prat A. Frontiers in Oncology. 2021 Apr 23;11:638482. doi: 10.3389/fonc.2021.638482. PMID: 33968735

Targeted therapy modulates the secretome of cancer-associated fibroblasts to induce resistance in HER2-positive breast cancer. Luque M, Sanz-Alvarez M, Santamaria A, Zazo S, Cristobal I, de la Fuente L, Minguez P, Eroles P, Rovira A, Albanell J, Madoz-Gurpide J, Rojo F. International Journal of Molecular Sciences. 2021 Dec 10;22(24):13297. doi: 10.3390/ijms222413297. PMID: 34948097

Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation. Martinez MT, Monton-Bueno J, Simon S, Ortega B, Moragon S, Rosello S, Insa A, Navarro J, Sanmartin A, Julve A, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner MJ, Cano A, Silvestre A, Teruel A, Lluch A, Cervantes A, Chirivella Gonzalez I. ESMO open. 2021 May 11;6(3):100148. doi: 10.1016/j.esmoop.2021.100148. PMID: 33989988

Trajectories of alcohol consumption during life and the risk of developing breast cancer. Donat-Vargas C, Guerrero-Zotano A, Casas A, Baena-Canada J, Lope V, Antolin S, Garcia-Saenz J, Bermejo B, Munoz M, Ramos M, de Juan A, Sanchez C, Sanchez-Rovira P, Anton A, Brunet J, Gavila J, Salvador J, Arellano E, Bezares S, de Larrea-Baz N, Perez-Gomez B, Martin M, Pollan M. British Journal of Cancer. 2021 Oct;125(8):1168-1176. doi: 10.1038/s41416-021-01492-w. PMID: 34483338

A multivariable prognostic score to guide systemic therapy in early-stage HER2-positive breast cancer: a retrospective study with an external evaluation. Prat A, Guarneri V, Pare L, Griguolo G, Pascual T, Dieci M, Chic N, Gonzalez-Farre B, Frassoldati A, Sanfeliu E, Cejalvo J, Munoz M, Bisagni G, Braso-Maristany F, Urso L, Vidal M, Brandes A, Adamo B, Musolino A, Miglietta F, Conte B, Oliveira M, Saura C, Pernas S, Alarcon J, Llombart-Cussac A, Cortes J, Manso L, Lopez R, Ciruelos E, Schettini F, Villagrasa P, Carey L, Perou C, Piacentini F, D’Amico R, Tagtiapco E, Parker J, Conte P. The Lancet Oncology. 2020 Nov;21(11):1455-1464. doi: 10.1016/S1470-2045(20)30450-2. PMID: 33152285

A Phase II prospective, randomized, double-blind, placebo-controlled and multicenter clinical trial to assess the safety of 0.005% estriol vaginal gel in hormone receptor-positive postmenopausal women with early stage breast cancer in treatment with aromatase inhibitor in the adjuvant setting. Sanchez Rovira P, Linden Hirschberg A, Gil Gil M, Bermejo De Las Heras B, Nieto Magro C. Oncologist. 2020 Dec;25(12):e1846-1854. doi: 10.1634/theoncologist.2020-0417. PMID: 32459035

A retrospective, multicenter study of the efficacy of lapatinib plus trastuzumab in HER2-positive metastatic breast cancer patients previously treated with trastuzumab, lapatinib, or both: the Trastyvere study. Gavila J, De La Haba J, Bermejo De Las Heras B, Rodriguez-Lescure A, Anton A, Ciruelos E, Brunet J, Munoz-Couselo E, Santisteban M, Rodriguez Sanchez C, Santaballa A, Sanchez Rovira P, Garcia Saenz J, Ruiz-Borrego M, Guerrero-Zotano A, Huerta Alvaro M, Cotes-Sanchis A, Lao Romera J, Aguirre E, Cortes J, Llombart-Cussac A. Clinical & Translational Oncology. 2020 Mar;22(3):420-428. doi: 10.1007/s12094-019-02145-4. PMID: 31203575

Association Between ABCB1 Genetic Variants and Persistent Chemotherapy-Induced Alopecia in Women With Breast Cancer. Nunez-Torres R, Martin M, Garcia-Saenz J, Rodrigo-Faus M, Del Monte-Millan M, Tejera-Perez H, Pita G, de la Torre-Montero J, Pinilla K, Herraez B, Peiró Chová L, Bermejo De Las Heras B, Lluch Hernández A, Gonzalez-Neira A. JAMA Dermatology. 2020 Sep 1;156(9):987-991. doi: 10.1001/jamadermatol.2020.1867. PMID: 32756886

Aurora kinases in ovarian cancer. Perez Fidalgo J, Gambardella V, Pineda Merlo B, Burgues Gasion O, Piñero Sanchez O, Cervantes Ruiperez A. ESMO Open. 2020 Oct;5(5):e000718. doi: 10.1136/esmoopen-2020-000718. PMID: 33087400

Autocrine CCL5 effect mediates trastuzumab resistance by ERK pathway activation in HER2-positive breast cancer. Zazo S, Gonzalez-Alonso P, Martin-Aparicio E, Chamizo C, Luque M, Sanz-Alvarez M, Minguez P, Gomez-Lopez G, Cristobal I, Carames C, Garcia-Foncillas J, Eroles Asensio P, Lluch Hernández A, Arpi O, Rovira A, Albanell J, Madoz-Gurpide J, Rojo F. Molecular Cancer Therapeutics. 2020 Aug;19(8):1696-1707. doi: 10.1158/1535-7163.MCT-19-1172. PMID: 32404410

Circulating miR-99a-5p Expression in Plasma: A Potential Biomarker for Early Diagnosis of Breast Cancer. Garrido Cano I, Constancio V, Adam Artigues A, Lameirinhas A, Simon Alonso S, Ortega Morillo B, Martinez Martinez M, Hernando Meliá C, Bermejo De Las Heras B, Lluch Hernández A, Lopes P, Henrique R, Jeronimo C, Cejalvo Andujar J, Eroles Asensio P. International Journal of Molecular Sciences. 2020 Oct 8;21(19):7427. doi: 10.3390/ijms21197427. PMID: 33050096

Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia. Ballester Garcia S, Pineda Merlo B, Rodrigues P, Tormo Martin E, Terol Castera M, Eroles Asensio P. Genes. 2020 Jun 23;11(6):686. doi: 10.3390/genes11060686. PMID: 32585853

Combination of phenotype and polygenic risk score in breast cancer risk evaluation in the Spanish population: a case -control study. Trivino J, Ceba A, Rubio-Solsona E, Serra D, Sanchez-Guiu I, Ribas G, Rosa R, Cabo M, Bernad L, Pita G, Gonzalez-Neira A, Legarda G, Diaz J, García Vigara A, Martinez Aspas A, Escrig M, Bermejo De Las Heras B, Eroles Asensio P, Ibanez J, Salas D, Julve Parreño A, Cano Sanchez A, Lluch Hernández A, Minambres R, Benitez J. BMC Cancer.2020 Nov 10;20(1):1079. doi: 10.1186/s12885-020-07584-9. PMID: 33167914

Differential expression of Receptor Activator of Nuclear Factor Kappa B in healthy endometrium, ovarian endometrioma and endometrioid ovarian cancer. Gregori Romero M, Rodriguez Garcia V, Burgues Gasion O, Martinez Carmona J, Tarin Folgado J, Cano Sanchez A, Gómez Gallego R. American Journal of Obstetrics and Gynecology. 2020 Mar;222(3):279-281. doi: 10.1016/j.ajog.2019.11.1259. PMID: 31765641

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease. Garcia-Recio S, Thennavan A, East M, Parker J, Cejalvo J, Garay J, Hollern D, He X, Mott K, Galvan P, Fan C, Selitsky S, Coffey A, Marron D, Braso-Maristany F, BURGUES GASION O, Albanell J, Rojo F, Lluch Hernández A, Martinez de Duenas E, Rosen J, Johnson G, Carey L, Prat A, Perou C. Journal of Clinical Investigation. 2020 Sep 1;130(9):4871-4887. doi: 10.1172/JCI130323. PMID: 32573490

HDAC5 Inhibitors as a Potential Treatment in Breast Cancer Affecting Very Young Women. Oltra Sanchis S, Cejalvo Andujar J, Tormo Martin E, Albanell M, Ferrer A, Nacher M, Bermejo De Las Heras B, Hernando Meliá C, Chirivella González I, Alonso Yuste E, Burgues Gasion O, Peña Chilet M, Eroles Asensio P, Lluch Hernández A, Ribas Despuig G, Martinez Martinez M. Cancers. 2020 Feb 10;12(2):412. doi: 10.3390/cancers12020412. PMID: 32050699

HER2-enriched subtype and ERBB2 expression in HER2-positive breast cancer treated with dual HER2 blockade. Prat A, Pascual T, De Angelis C, Gutierrez C, Llombart-Cussac A, Wang T, Cortes J, Rexer B, Pare L, Forero A, Wolff A, Morales S, Adamo B, Braso-Maristany F, Vidal M, Veeraraghavan J, Krop I, Galvan P, Pavlick A, Bermejo De Las Heras B, Izquierdo M, Rodrik-Outmezguine V, Reis-Filho J, Hilsenbeck S, Oliveira M, Dieci M, Griguolo G, Fasani R, Nuciforo P, Parker J, Conte P, Schiff R, Guarneri V, Osborne C, Rimawi M. Jnci-Journal of the National Cancer Institute. 2020 Jan 1;112(1):46-54. doi: 10.1093/jnci/djz042. PMID: 31037288

Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Spain: Clinical and Genetic Characterization. Sanchez-Heras A, Castillejo A, Garcia-Diaz J, Robledo M, Teule A, Sanchez R, Zuniga A, Lastra E, Duran M, Llort G, Yague C, Ramon Y Cajal T, Lopez San Martin C, Lopez-Fernandez A, Balmana J, Robles L, Mesa-Latorre J, Chirivella González I, Fonfria M, Perea Ibanez R, Castillejo M, Escandell Gonzalez I, Gomez L, Berbel P, Soto J. Cancers. 2020 Nov 5;12(11):3277. doi: 10.3390/cancers12113277. PMID: 33167498

Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial. Quintela-Fandino M, Holgado E, Manso L, Morales S, Bermejo De Las Heras B, Colomer R, Apala J, Blanco R, Munoz M, Caleiras E, Iranzo V, Martinez M, Dominguez O, Hornedo J, Gonzalez-Cortijo L, Cortes J, Gasol Cudos A, Malon D, Lopez-Alonso A, Moreno-Ortiz M, Mouron S, Manes S. Breast cancer research. 2020 Nov 11;22(1):124. doi: 10.1186/s13058-020-01362-y. PMID: 33176887

In the literature: August 2020. Gambardella V, Cejalvo J, Tarazona N, Cervantes A. ESMO Open. 2020 Aug;5(4):e000909. doi: 10.1136/esmoopen-2020-000909. PMID: 32817070

In the literature: December 2019. Gambardella V, Insa A, Cejalvo J, Cervantes A. ESMO Open. 2020 Jan;5(1):e000642. doi: 10.1136/esmoopen-2019-000642. PMID: 31958287

In the literature: February 2020. Roda D, Gambardella V, Cejalvo JM, Cervantes A. ESMO Open. 2020 Feb;5(1):e000680. doi: 10.1136/esmoopen-2020-000680. PMID: 32079625

In the literature: June 2020. Roda D, Gambardella V, Cejalvo JM, Cervantes A. ESMO Open. 2020 Jul;5(4):e000832. doi: 10.1136/esmoopen-2020-000832. PMID: 32641355

KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi’s sarcoma. Medina M, D’Agostino A, Ma Q, Eroles P, Cavallin L, Chiozzini C, Sapochnik D, Cymeryng C, Hyjek E, Cesarman E, Naipauer J, Mesri E, Coso O. PLoS pathogens. 2020 Oct 15;16(10):e1009006. doi: 10.1371/journal.ppat.1009006. PMID: 33057440

MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma. Pattanayak C, Garrido Cano I, Adam Artigues A, Tormo Martin E, Pineda Merlo B, Cabello Navarro P, Alonso Yuste E, Bermejo De Las Heras B, Hernando Meliá C, Martinez Martinez M, Rovira A, Albanell J, Rojo F, Burgues Gasion O, Cejalvo Andujar J, Lluch Hernández A, Eroles Asensio P. Frontiers in Oncology. 2020 Sep 10;10:1661. doi: 10.3389/fonc.2020.01661. PMID: 33014831

Mu Opioid Receptor 1 (MOR-1) Expression in Colorectal Cancer and Oncological Long-Term Outcomes: A Five-Year Retrospective Longitudinal Cohort Study. Diaz-Cambronero O, Mazzinari G, Giner F, Belltall A, Ruiz-Boluda L, Marques-Mari A, Sanchez-Guillen L, Eroles Asensio P, Cata J, Argente-Navarro M. Cancers. 2020 Jan 5;12(1):134. doi: 10.3390/cancers12010134. PMID: 31948099

Neoadjuvant treatment for locally advanced unresectable and borderline resectable pancreatic cancer: oncological outcomes at a single academic centre. Rosello S, Pizzo C, Huerta M, Munoz E, Aliaga R, Vera A, Alfaro-Cervello C, Jorda E, Garces-Albir M, Roda D, Dorcaratto D, Tarazona N, Torondel S, Guijarro J, Sanchiz V, Gambardella V, Fleitas-Kanonnikoff T, Lluch P, Pascual I, Ferrandez A, Sabater L, Cervantes A. ESMO Open. 2020 Nov;5(6):e000929. doi: 10.1136/esmoopen-2020-000929. PMID: 33229503

Palbociclib and trastuzumab in HER2-positive advanced breast cancer: Results from the phase II SOLTI-1303 PATRICIA trial. Ciruelos E, Villagrasa P, Pascual T, Oliveira M, Pernas S, Pare L, Escriva-de-Romani S, Manso L, Adamo B, Martinez de Duenas E, Cortes J, Vazquez S, Perello A, Garau I, Mele M, Martinez Janez N, Montano A, Bermejo De Las Heras B, Morales S, Echarri M, Vega E, Gonzalez-Farre B, Martinez D, Galvan P, Canes J, Nuciforo P, Gonzalez Farre X, Prat A. Clinical Cancer Research. 2020 Nov 15;26(22):5820-5829. doi: 10.1158/1078-0432.CCR-20-0844. PMID: 32938620

Palbociclib combined with endocrine therapy in heavily pretreated HR+/HER2(-) advanced breast cancer patients: Results from the compassionate use program in Spain (PALBOCOMP). Manso L, Hernando C, Galan M, Oliveira M, Cabrera MA, Bratos R, Rodriguez CA, Ruiz Borrego M, Blanch S, Llombart Cussac A, Delgado Mingorance JI, Alvarez Busto I, Gallegos I, Gonzalez Cortijo L, Morales S, Aguirre E, Hernando BA, Ballesteros A, Ales-Martinez J, Reboredo C, Oltra A, Gonzalez Cao M, Santisteban M, Malon D, Echeverria I, Garcia Garre E, Vega E, Servitja S, Andres R, Robles CE, Lopez R, Galve E, Echarri MJ, Legeren M, Moreno F. Breast. 2020 Dec;54:286-292. doi: 10.1016/j.breast.2020.11.005. PMID: 33242755

Personalized Medicine: Recent Progress in Cancer Therapy. Gambardella V, Tarazona Llavero N, Cejalvo Andujar J, Lombardi P, Huerta Alvaro M, Roselló Keränen S, Fleitas Kanonnikoff T, Roda Perez D, Cervantes Ruiperez A. Cancers. 2020 Apr 19;12(4):1009. doi: 10.3390/cancers12041009. PMID: 32325878

Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer. Garrido-Castro A, Saura C, Barroso-Sousa R, Guo H, Ciruelos E, Bermejo B, Gavila J, Serra V, Prat A, Pare L, Celiz P, Villagrasa P, Li Y, Savoie J, Xu Z, Arteaga C, Krop I, Solit D, Mills G, Cantley L, Winer E, Lin N, Rodon J. Breast Cancer Research. 2020 Nov 2;22(1):120. doi: 10.1186/s13058-020-01354-y. PMID: 33138866

Phase III study to evaluate patient’s preference of subcutaneous versus intravenous trastuzumab in HER2-positive metastatic breast cancer patients: Results from the ChangHER study (GEICAM/2012-07). Ciruelos E, Montano A, Rodriguez C, Gonzalez-Flores E, Lluch Hernández A, Garrigos L, Quiroga V, Anton A, Malon D, Chacon J, Velasco M, Gonzalez-Cortijo L, Jolis L, Echarri M, Munoz M, Pascual T, Amigo Y, Casas M, Carrasco E, Casas A. European Journal of Cancer Care. 2020 Jul;29(4):e13253. doi: 10.1111/ecc.13253. PMID: 32578279

Phase III Trial of Adjuvant Capecitabine After Standard Neo-/Adjuvant Chemotherapy in Patients With Early Triple-Negative Breast Cancer (GEICAM/2003-11_CIBOMA/2004-01). Lluch Hernández A, Barrios C, Torrecillas L, Ruiz-Borrego M, Bines J, Segalla J, Guerrero-Zotano A, Garcia-Saenz J, Torres R, de la Haba J, Garcia-Martinez E, Gomez H, Llombart A, Salvador Bofill J, Baena-Canada J, Barnadas A, Calvo L, Perez-Michel L, Ramos M, Fernandez I, Rodriguez-Lescure A, Cardenas J, Vinholes J, Martinez de Duenas E, Godes M, Segui M, Anton A, Lopez-Alvarez P, Moncayo J, Amorim G, Villar E, Reyes S, Sampaio C, Cardemil B, Escudero M, Bezares S, Carrasco E, Martin M, Corona J, Jara C, Cardemil B, Toro R, Pimentel C, Hernando B, Vicente E, Zagame L, Gil M, Garcia Estevez L, Rodriguez C, de la Cruz M, Tello J, Campos S, Lomas M, Capdevile D, Campos M, Margeli M, Andres R, Tusquets I, Ballesteros A, Guerrero A, Arguello M, Rodriguez J, Munoz M, Florian J, Azevedo S, Mondragon R, Peralta J, Palomo A, Barajas L, Arcusa A, Carranza H, Garcia C, Umbria C, Ales J, Lopez Vega J, Romeo M, Valero J, Alonso J, Mathias C, Gutierrez F, Adrover E, Nunez P, Mendiola C, Cassinello J, de la Huerta A, Geicam Spanish Breast Canc Grp, CIBOMA Iberoamer Coalition Res Bre, LACOG. Journal of Clinical Oncology. 2020 Jan 20;38(3):203-213. doi: 10.1200/JCO.19.00904. PMID: 31804894

Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade. Braso-Maristany F, Griguolo G, Pascual T, Pare L, Nuciforo P, Llombart-Cussac A, Bermejo De Las Heras B, Oliveira M, Morales S, Martinez N, Vidal M, Adamo B, Martinez O, Pernas S, Lopez R, Munoz M, Chic N, Galvan P, Garau I, Manso L, Alarcon J, Martinez E, Gregorio S, Gomis R, Villagrasa P, Cortes J, Ciruelos E, Prat A. Nature Communications. 2020 Jan 20;11(1):385. doi: 10.1038/s41467-019-14111-3. PMID: 31959756

Polymorphisms in genes involved in T-cell co-stimulation are associated with blood pressure in women. Pineda Merlo B, Pertusa Viñuales C, Panach Gonzalez L, Tarin Folgado J, Cano Sanchez A, García Pérez M. Gene. 2020 Sep 5;754:144838. doi: 10.1016/j.gene.2020.144838. PMID: 32525043

Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study. Fernandez de Larrea-Baz N, Perez-Gomez B, Guerrero-Zotano A, Casas A, Bermejo De Las Heras B, Baena-Canada J, Antolin S, Sanchez-Rovira P, Ramos Vazquez M, Garcia-Saenz J, Anton A, Munoz M, de Juan A, Jara C, Chacon J, Arcusa A, Gil-Gil M, Adrover E, Oltra A, Brunet J, Gonzalez S, Bezares S, Lope V, Martin M, Pollan M. Scientific Reports. 2020 May 8;10(1):7741. doi: 10.1038/s41598-020-63637-w. PMID: 32385335

Reply to Y. Usui et al. Lluch Hernández A, Barrios C, Torrecillas L, Martin M. Journal of Clinical Oncology. 2020 Jun 20;38(18):2113-2114. doi: 10.1200/JCO.20.00390. PMID: 32352858

Ribociclib plus letrozole versus chemotherapy for postmenopausal women with hormone receptor-positive, HER2-negative, luminal B breast cancer (CORALLEEN): an open-label, multicentre, randomised, phase 2 trial. Prat A, Saura C, Pascual T, Hernando C, Munoz M, Pare L, Farre B, Fernandez P, Galvan P, Chic N, Farre X, Oliveira M, Gil-Gil M, Arumi M, Ferrer N, Montano A, Izarzugaza Y, Llombart-Cussac A, Bratos R, Santiago S, Martinez E, Hoyos S, Rojas B, Virizuela J, Ortega V, Lopez R, Celiz P, Ciruelos E, Villagrasa P, Gavila J. Lancet Oncology. 2020 Jan;21(1):33-43. doi: 10.1016/S1470-2045(19)30786-7. PMID: 31838010

SEOM clinical guideline for treatment of kidney cancer (2019). Lazaro M, Valderrama B, Suarez C, De-Velasco G, Beato C, Chirivella González I, Gonzalez-del-Alba A, Lainez N, Mendez-Vidal M, Arranz J. Clinical & Translational Oncology. 2020 Feb;22(2):256-269. doi: 10.1007/s12094-019-02285-7. PMID: 31993962

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype. Lope V, Guerrero-Zotano A, Casas A, Baena-Canada J, Bermejo B, Perez-Gomez B, Criado-Navarro I, Antolin S, Sanchez-Rovira P, Ramos-Vazquez M, Anton A, Castello A, Garcia-Saenz J, Munoz M, de Juan A, Andres R, Llombart-Cussac A, Hernando B, Franquesa R, Caballero R, Priego-Capote F, Martin M, Pollan M. Nutrients. 2020 Oct 14;12(10):3132. doi: 10.3390/nu12103132. PMID: 33066483

SOLTI-1503 PROMETEO TRIAL: combination of talimogene laherparepvec with atezolizumab in early breast cancer. Pascual T, Cejalvo Andujar J, Oliveira M, Vidal M, Vega E, Ganau S, Julve Parreño A, Zamora E, Miranda I, Delgado A, Bermejo De Las Heras B, la Cruz-Merino L, Juan M, Ferrero-Cafiero J, Canes J, Gonzalez X, Villagrasa P, Prat A. Future oncology (London, England). 2020 Aug;16(24):1801-1813. doi: 10.2217/fon-2020-0246. PMID: 32633563

The economic burden of metastatic breast cancer in Spain. Bermejo de las Heras B, Ramon y Cajal J, Galve Calvo E, de la Haba Rodriguez J, Garcia Mata J, Moreno Anton F, Pelaez Fernandez I, Rodriguez Lescure A, Rodriguez Sanchez CA, Ruiz-Borrego M, Remak E, Barra M, Rivero M, Soto Alvarez J. European Journal of Hospital Pharmacy-Science and Practice. 2020 Jan;27(1):19-24. doi: 10.1136/ejhpharm-2017-001453. PMID: 32064084

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver. Hruschka N, Kalisz M, Subijana M, Grana-Castro O, Del Cano-Ochoa F, Brunet L, Chernukhin I, Sagrera A, De Reynies A, Kloesch B, Chin S, Burgues Gasion O, Andreu D, Bermejo De Las Heras B, Cejalvo Andujar J, Sutton J, Caldas C, Ramon-Maiques S, Carroll J, Prat A, Real F, Martinelli P. Oncogene. 2020 Aug;39(32):5455-5467. doi: 10.1038/s41388-020-1376-3. PMID: 32587399

The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer.. Gonzalez-Alonso P, Zazo S, Martin-Aparicio E, Luque M, Chamizo C, Sanz-Alvarez M, Minguez P, Gomez-Lopez G, Cristobal I, Carames C, Garcia-Foncillas J, Eroles Asensio P, Lluch Hernández A, Arpi O, Rovira A, Albanell J, Piersma S, Jimenez C, Madoz-Gurpide J, Rojo F. Cancers. 2020 Apr 29;12(5):1108. doi: 10.3390/cancers12051108. PMID: 32365528

Tumor-Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation. Fernandez-Nogueira P, Mancino M, Fuster G, Lopez-Plana A, Jauregui P, Almendro V, Enreig E, Menendez S, Rojo F, Noguera-Castells A, Bill A, Gaither L, Serrano L, Recalde-Percaz L, Moragas N, Alonso R, Ametller E, Rovira A, Lluch Hernández A, Albanell J, Gascon P, Bragado P. Clinical Cancer Research. 2020 Mar 15;26(6):1432-1448. doi: 10.1158/1078-0432.CCR-19-0353. PMID: 31699826

Projects
Reference: PI21/01351
Title: Predicción de enfermedad residual después de la terapia neoadyuvante en cáncer de mama HER2 positivo e identificación de estrategias para superar la resistencia
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Pilar Eroles Asensio
Duration: 2022 – 2024
Total budget: 123.420 €
Reference: 965231-REBECCA
Title: REsearch on BrEast Cancer induced chronic conditions supported by Causal Analysis of multi-source data
Funding body: European Commission
Principal Investigator: Aristotelio Panepistimio Thessalonikis
Duration: 2021 – 2025
Total budget: 466.125,00 €
Reference: PI18/00817
Title: Caracterización molecular del cáncer de mama gestacional
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Juan de la Haba Rodríguez
Duration: 2019 – 2021
Total budget: 146.159,53
Reference: PI18/01219
Title: Caracterización y repercusión terapéutica de la ecología de cáncer de mama HER2 positivo
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Pilar Eroles Asensio
Duration: 2019 – 2021
Total budget: 112.530 €
Reference: CB16/12/00481
Title: CIBER Cáncer de mama
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Ana Lluch Hernández, Emilio Alba Conejo
Duration: 2017 – 2021
Total budget:
Reference: COST Action CA15204
Title: European Platform for Outcomes Research into Perioperative Interventions during Surgery for Cancer
Funding body: European Commission
Principal Investigator: Pilar Eroles Asensio
Duration: 2016 – 2020
Total budget:
+ Info
SEOM clinical guideline for treatment of kidney cancer (2019). Lazaro M, Valderrama B, Suarez C, De-Velasco G, Beato C, Chirivella González I, Gonzalez-del-Alba A, Lainez N, Mendez-Vidal M, Arranz J. Clinical & Translational Oncology. 2020 Feb;22(2):256-269. doi: 10.1007/s12094-019-02285-7. PMID: 31993962

SEOM clinical guideline for treatment of kidney cancer (2017) (vol 20, pg 47, 2018). Gallardo E, Méndez-Vidal MJ, Pérez-Gracia JL, Sepúlveda-Sánchez JM, Campayo M, Chirivella-González I, García-Del-Muro X, González-Del-Alba A, Grande E, Suárez C. Clinical & Translational Oncology. 2019 May;21(5):692-693. doi: 10.1007/s12094-019-02058-2. PMID: 30798511

SEOM clinical guideline on heritable TP53-related cancer syndrome (2022). Sanchez-Heras A, Cajal T, Pineda M, Aguirre E, Grana B, Chirivella I, Balmana J, Brunet J. Clinical & Translational Oncology. 2023 May 3. doi: 10.1007/s12094-023-03202-9. PMID: 37133731

Title: Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker
Doctoral candidate: Adam Artigues, Anna
Director(s): Lluch Hernández, Ana; Eroles Asensio, Pilar
Date of the defense: 12/04/2022
University: Universitat de València

Title: Role of miR-99a-5p in breast cancer: translating molecular findings into clinical tool
Doctoral candidate: Garrido Cano, Iris
Director(s): Eroles Asensio, Pilar; Martínez Máñez, Ramón
Date of the defense: 17/12/2021
University: Universitat Politècnica de València

Title: Involvement of EZH2-MYC loop and SALL4 in epithelial-mesenchymal transition (EMT) and trastuzumab resistance process in HER2+ breast cancer
Doctoral candidate: Pattanayak Pattanayak, Chaudhuri Birlipta
Director(s): Eroles Asensio, Pilar; Cejalvo Andújar, Juan Miguel
Date of the defense: 26/02/2021
University: Universitat de València

Title: Estudio de las alteraciones genéticas asociadas con la resistencia al tratamiento neoadyuvante de deprivación estrogénica en cáncer de mama
Doctoral candidate: Guerrero Zotano, Ángel Luis
Director(s): López Guerrero, José Antonio; Guillem Porta, Vicente; Lluch Hernández, Ana
Date of the defense: 21/01/2021
University: Universitat de València

Title: Implicaciones del MAMMI-PET en el diagnóstico y tratamiento del cáncer de mama. Comparación con los resultados anatomopatológicos y con otras pruebas de imagen
Doctoral candidate: De Andrés Gómez, Alejandra
Director(s): Fuster Diana, Carlos Alberto; Villalba Ferrer, Francisco Leopoldo; Lluch Hernández, Ana
Date of the defense: 16/10/2020
University: Universitat de València

Title: Epigenetic regulation of resistance to treatments in triple negative and HER2+ breast cancer: mirnas involved
Doctoral candidate: Cabello Navarro, Paula
Director(s): Erolés Asensio, Pilar; Lluch Hernández, Ana
Date of the defense: 28/09/2020
University: Universitat Politècnica de València

Title: Uncovering the molecular and cellular mechanisms of metastatic dormancy in luminal breast cancer
Doctoral candidate: Cejalvo Andújar, Juan Miguel
Director(s): Gomis Cabré, Roger; Prat Aparicio, Aleix; Palacín Prieto, Manuel
Date of the defense: 22/01/2020
University: University de Barcelona

Title: Evaluación de los cambios en la respuesta linfocitaria en el microambiente tumoral como factor pronóstico y predictivo de respuesta a la quimioterapia neoadyuvante del cáncer de mama triple negativo estadio ii-iii
Doctoral candidate: Herrero Vicent, Carmen
Director(s): Ruiz Simón, Amparo; Calatrava Fons, Ana; Guillem Porta, Vicente; Lluch Hernández, Ana
Date of the defense: 27/05/2019
University: Universitat de València

Title: Identificación de biomarcadores circulantes con valor pronóstico y predictivo de respuesta en cáncer de mama triple negativo
Doctoral candidate: Salvador Coloma, Carmen
Director(s): Lluch Hernández, Ana; Santaballa Bertrán, Ana María; Font de Mora Sainz, Jaime
Date of the defense: 10/05/2019
University: Universitat de València

Title: Identificación de los factores clínico-patológicos relacionados con la obtención de la respuesta completa patológica en pacientes con cáncer de mama tratadas con quimioterapia neoadyuvante. Validación del residual cancer burden (rcb) como factor pronóstico
Doctoral candidate: Pons Sanz, Vanesa
Director(s): Lluch Hernández, Ana; Pérez Fidalgo, Jose Alejandro; Burgués Gasión, Octavio
Date of the defense: 02/04/2019
University: Universitat de València

Title: Study of the epi-/genomic dysregulation of breast cancer in women under 35 years and evaluation of cellular models
Doctoral candidate: Oltra Sanchis, Sara
Director(s): Ribas Despuig, Gloria; Lluch Hernández, Ana
Date of the defense: 18/01/2019
University: Universitat de València