Research Group on Rare Respiratory Diseases (RRD)

Metabolism and Organic Damage Area

We have shown that NK and lymphocytes B express and secrete alpha-1 antitrypsin

We have discovered a group of miRNAs that could be used for the diagnosis and prognosis of alpha-1 antitrypsin deficiency. We are currently validating these results using an external cohort

A new method based on oxidative stress markers to identify patients with Primary Ciliary Dyskinesia has been set up

We have set up the high-speed video method to identify patients with Primary Ciliary Dyskinesia

We have shown that hypoxia modifies neutrophil degranulation and enhances oxidative damage in alpha-1 antitrypsin deficiency patients

Dr. Francisco Dasí Fernández
Coordinator
Dr. Francisco Dasí Fernández
francisco.dasi@uv.es  

RESEARCHERS
Leading, R4
Established, R3

Selene Valero Moreno
Francisco Dasí Fernández    

Recognised/Emerging, R2

María Magallón Serrano
Silvia Castillo Corullón

First Stage, R1

Daniel Pellicer Roig

STAFF
Collaborating Researchers

Mª Mercedes Navarro García

Nurse
Technicians

Miguel Ángel Esteve Gimeno
Néstor Navarro Ortí

Administrative assistant
Publications
Alpha-1 antitrypsin deficiency. Dasi F. Medicina Clinica. 2023 Mar 10;160(5):203-205. doi: 10.1016/j.medcli.2022.09.001. PMID: 36253208

Family styles and quality of life in adolescents with bronchial asthma: The important role of self-esteem and perceived threat of the disease. Valero-Moreno S, Montoya-Castilla I, Perez-Marin M. Pediatric Pulmonology. 2023 Jan;58(1):178-186. doi: 10.1002/ppul.26178. PMID: 36193795

Quality of life in patients with asthma: Medical indicators and psychological variables. Valero-Moreno S, Montoya-Castilla I, Perez-Marin M. Journal of Pediatric Nursing. 2023 Jan 4:S0882-5963(22)00345-1. doi: 10.1016/j.pedn.2022.12.030. PMID: 36609027

10Vida: a mental and physical health intervention for chronically ill adolescents and their caregivers in the hospital setting: an open study. Rodriguez-Rubio P, Lacomba-Trejo L, Valero-Moreno S, Montoya-Castilla I, Perez-Marin M. International Journal of Environmental Research and Public Health. 2022 Mar 8;19(6):3162. doi: 10.3390/ijerph19063162. PMID: 35328851

Benefits of a support programme for family caregivers of patients at the end of life: A randomised controlled trial. Soto Rubio A, Valero Moreno S, Perez Marin M. Journal of Health Psychology. 2022 Jan;27(1):199-210. doi: 10.1177/1359105320944993. PMID: 32772853

Cross-cultural validation of the Worries about COVID-19 and its consequences Scale (W-COV) in adolescents and young people. Monaco E, Schoeps K, Valero-Moreno S, Castro-Calvo J, Montoya-Castilla I, del Rosario C, Coello F, Herrera S, Trujillo A, Munevar F, Esparza NA. Archives of Psychiatric Nursing. 2022 Oct;40:158-166. doi: 10.1016/j.apnu.2022.07.016. PMID: 36064240

Do COVID-19 worries, resilience and emotional distress influence life satisfaction? outcomes in adolescents in Ecuador during the Pandemic: SEM vs. QCA. Herrera J, Lacomba-Trejo L, Valero-Moreno S, Montoya-Castilla I, Perez-Marin M. Children. 2022 Mar 21;9(3):439. doi: 10.3390/children9030439. PMID: 35327811

Emotional IMPACT IN ADOLESCENTS in Ecuador Six Months After The Beginning of the COVID-19 Pandemic. Coello M, Valero-Moreno S, Herrera J, Lacomba-Trejo L, Perez-Marin M. Journal of Psychology. 2022;156(5):381-394. doi: 10.1080/00223980.2022.2054921. PMID: 35482962

Geographic distribution and phenotype of European people with cystic fibrosis carrying A1006E mutation. Mondejar-Lopez P, Zolin A, Garcia-Marcos P, Pastor-Vivero M, Rosa-Silvestre M, Sanchez-Martinez F, Salvatore D, Cimino G, Majo F, Sole-Jover A, de la Cruz O, Calderazzo M, Pizzamiglio G, Castillo-Corullon S, Alvarez-Fernandez A, Gartner S, Padoan R, Carnovale V, Salvatore M, Moya-Quiles M, Orenti A, Glover G, Sanchez-Solis M. Respiratory Medicine. 2022 Feb;192:106736. doi: 10.1016/j.rmed.2022.106736. PMID: 35032736

Incidence and prevalence of children’s diffuse lung disease in Spain. Torrent-Vernetta A, Gaboli M, Castillo-Corullon S, Mondejar-Lopez P, Santiago V, Costa-Colomer J, Osona B, Torres-Borrego J, De la Serna-Blazquez O, Alonso S, Aguilera P, De Atauri A, Soria A, Ayats R, de Vicente C, Gonzalez V, Gonzalez J, Calderin E, Pastor-Vivero M, Alvarez M, Rovira-Amigo S, Serrano I, Izquierdo A, Messa I, Gartner S, Navarro A, Baz-Redon N, Carmona R, Camats-Tarruella N, Fernandez-Cancio M, Rapp C, Dopazo J, Griese M, Moreno-Galdo A. Archivos de Bronconeumologia. 2022 Jan;58(1):22-29. doi: 10.1016/j.arbres.2021.06.001. PMID: 35249699

Longitudinal analysis of adolescent adjustment: the role of attachment and emotional competence. Jimenez-Rodriguez T, De la Barrera U, Schoeps K, Valero-Moreno S, Montoya-Castilla I. Children. 2022 Nov 8;9(11):1711. doi: 10.3390/children9111711. PMID: 36360439

Perceived stress in the primary caregivers of adolescents with asthma: a cross-sectional study. Valero-Moreno S, Montoya-Castilla I, Schoeps K, Postigo-Zegarra S, Perez-Marin M. Children. 2022 Oct 25;9(11):1614. doi: 10.3390/children9111614. PMID: 36360342

Psychological aspects of pre-adolescents or adolescents with precocious puberty: a systematic review. Lopez-Miralles M, Lacomba-Trejo L, Valero-Moreno S, Benavides G, Perez-Marin M. Journal of Pediatric Nursing. 2022 May-Jun;64:e61-e68. doi: 10.1016/j.pedn.2022.01.002. PMID: 35033399

Teachers’ response to stress, anxiety and depression during COVID-19 lockdown: what have we learned from the pandemic?. Lacomba-Trejo L, Schoeps K, Valero-Moreno S, Del Rosario C, Montoya-Castilla I. Journal of School Health. 2022 Sep;92(9):864-872. doi: 10.1111/josh.13192. PMID: 35610141

The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN. Raidt J, Maitre B, Pennekamp P, Altenburg J, Anagnostopoulou P, Armengot M, Bloemsma L, Boon M, Borrelli M, Brinkmann F, Carr S, Carroll M, Castillo-Corullon S, Coste A, Cutrera R, Dehlink E, Destouches D, Di Cicco M, Dixon L, Emiralioglu N, Eralp E, Haarman E, Hogg C, Karadag B, Kobbernagel H, Lorent N, Mall M, Marthin J, Martinu V, Narayanan M, Ozcelik U, Peckham D, Pifferi M, Pohunek P, Polverino E, Range S, Ringshausen F, Robson E, Roehmel J, Rovira-Amigo S, Santamaria F, Schlegtendal A, Szepfalusi Z, Tempels P, Thouvenin G, Ullmann N, Walker W, Wetzke M, Yiallouros P, Omran H, Nielsen K. ERJ Open Research. 2022 Aug 15;8(3):00139-2022. doi: 10.1183/23120541.00139-2022. PMID: 35983540

The relation of CFTR-genotype and associated comorbidities to development of pulmonary atelectasis in cystic fibrosis patients. Martinez-Redondo M, Prados Sanchez C, Garcia-Rio F, Quintana Gallego E, Castillo Corullon S, Salcedo Posadas A, Giron Moreno R, Martinez Martinez M, Maiz Carro L, de Vicente C, Costa Colomer J, Alvarez-Sala Walther R. Archivos de Bronconeumologia. 2022 Sep;58(9):666-668. doi: 10.1016/j.arbres.2022.02.009. PMID: 35644710

Clinically amyopathic dermatomyositis with pulmonary involvement, exceptional pathology. Navio Anaya M, Monrabal Bernabeu A, Pons Morales S, Castillo Corullon S. Anales de Pediatria. 2021 Jan 18;S1695-4033(20)30517-8. doi: 10.1016/j.anpedi.2020.11.029. PMID: 33478851

Comparison of physical activity and sedentary behaviour between schoolchildren with cystic fibrosis and healthy controls: a gender analysis. Valencia-Peris A, Lizandra J, Moya-Mata I, Gomez-Gonzalvo F, Castillo-Corullon S, Escribano A. International Journal of Environmental Research and Public Health. 2021 May 18;18(10):5375. doi: 10.3390/ijerph18105375. PMID: 34070042

Empirically supported psychological treatments for children and adolescents: state of the art. Fonseca-Pedrero E, Perez-Alvarez M, Al-Halabi S, et al. Psicothema. 2021 Aug;33(3):386-398. doi: 10.7334/psicothema2021.56. PMID: 34297668

Implementation of a Gene Panel for Genetic Diagnosis of Primary Ciliary Dyskinesia. Baz-Redon N, Rovira-Amigo S, Paramonov I, Castillo Corullon S, Cols Roig M, Antolin M, Garcia Arumi E, Torrent-Vernetta A, De Mir Messa I, Gartner S, Iglesias Serrano I, Caballero-Rabasco M, Asensio De La Cruz O, Vizmanos-Lamotte G, Martin De Vicente C, Martinez-Colls M, Reula Martin A, Escribano Montaner A, Dasí Fernández F, Armengot Carceller M, Polverino E, Amengual Pieras E, Amaro-Rodriguez R, Garrido-Pontnou M, Tizzano E, Camats-Tarruella N, Fernandez-Cancio M, Moreno-Galdo A. Archivos de Bronconeumologia. 2021 Mar;57(3):186-194. doi: 10.1016/j.arbres.2020.02.010. PMID: 32253119

Is mHealth a useful therapy for improving physical or emotional health in adolescents with cystic fibrosis? a systematic review. Valero-Moreno S, Lacomba-Trejo L, Montoya-Castilla I, Perez-Marin M. Current Psychology. 2021 Nov 24;1-14. doi: 10.1007/s12144-021-02452-6. PMID: 34840486

Methodologies for the determination of blood Alpha1 antitrypsin levels: a systematic review. Ruiz-Duque B, Banuls L, Reinoso-Arija R, Carrasco-Hernandez L, Caballero-Eraso C, Dasi F, Lopez-Campos JL. Journal of Clinical Medicine. 2021 Oct 31;10(21):5132. doi: 10.3390/jcm10215132. PMID: 34768650

New laboratory protocol to determine the oxidative stress profile of human nasal epithelial cells using flow cytometry. Reula A, Pellicer D, Castillo S, Magallon M, Armengot M, Herrera G, O’Connor J, Banuls L, Navarro-Garcia M, Escribano A, Dasi F. Journal of Clinical Medicine. 2021 Mar 11;10(6):1172. doi: 10.3390/jcm10061172. PMID: 33799667

Oxidative stress and endoplasmic reticulum stress in rare respiratory diseases. Magallon M, Carrion A, Banuls L, Pellicer D, Castillo S, Bondia S, Navarro-Garcia M, Gonzalez C, Dasi F. Journal of Clinical Medicine. 2021 Mar 18;10(6):1268. doi: 10.3390/jcm10061268. PMID: 33803835

Predicting health-related quality of life in Spanish adolescents with allergic rhinoconjunctivitis and bronchial asthma. Lacomba-Trejo L, Valero-Moreno S, Montoya-Castilla I, Marin M. Psychology Health & Medicine. 2021 Mar 24:1-13. doi: 10.1080/13548506.2021.1904514. PMID: 33759655

Predictors of complicated grief in mourners of sudden cardiac death. Soto-Rubio A, Valero-Moreno S, Perez-Marin M. American Journal of Emergency Medicine. 2021 Dec;50:797-798. doi: 10.1016/j.ajem.2021.03.028. PMID: 33741200

Prevention of teratogenesis in pregnancies of obese rats by vitamin E supplementation. Alcala M, Bolado V, Sanchez-Vera I, Clapes S, Dasi F, Saez G, Carrera E, Alvarez-Gallego F, Loeken M, Viana M. Antioxidants. 2021 Jul 23;10(8):1173. doi: 10.3390/antiox10081173. PMID: 34439421

Psycho-emotional adjustment in parents of adolescents: A cross-sectional and longitudinal analysis of the impact of the COVID pandemic. Valero-Moreno S, Lacomba-Trejo L, Tamarit A, Perez-Marin M, Montoya-Castilla I. Journal of pediatric nursing. 2021;59:e44-e51. doi: 10.1016/j.pedn.2021.01.028. PMID: 33608182

Repeated aspiration pneumonia in a 7-year-old girl with undiagnosed congenital tracheoesophageal fistula. Piolatti-Luna A, Castillo-Corrullon S. Archivos de Bronconeumologia. 2021 Aug;57(8):545. doi: 10.1016/j.arbr.2021.05.015. PMID: 34147349

Attitudes, Sentiments, and Concerns About Inclusive Education of Teachers and Teaching Students in Spain. Navarro-Mateu D, Franco-Ochoa J, Valero Moreno S, Prado Gasco V. Frontiers in Psychology. 2020 Apr 7;11:521. doi: 10.3389/fpsyg.2020.00521. PMID: 32318002

Childhood adaptation: perception of the parenting style and the anxious-depressive symptomatology. Schoeps K, Valero Moreno S, Perona A, Perez Marin M, Montoya Castilla I. Journal for Specialists in Pediatric Nursing. 2020 Oct;25(4):e12306. doi: 10.1111/jspn.12306. PMID: 32762136

COPD at the end of life: predictors of the emotional distress of patients and their family caregivers. Soto-Rubio A, Valero Moreno S, Diaz Cordobes J, Andreu Y, Perez Marin M. PLoS One. 2020 Oct 16;15(10):e0240821. doi: 10.1371/journal.pone.0240821. PMID: 33064747

Gene Therapy in Rare Respiratory Diseases: What Have We Learned So Far?. Bañuls Soto L, Pellicer Roig D, Castillo Corullon S, Navarro García M, Magallón Serrano M, González C, Dasí Fernández F. Journal of Clinical Medicine. 2020 Aug 8;9(8):2577. doi: 10.3390/jcm9082577. PMID: 32784514

I’m Not Good for Anything and That’s Why I’m Stressed: Analysis of the Effect of Self-Efficacy and Emotional Intelligence on Student Stress Using SEM and QCA. Navarro-Mateu D, Alonso-Larza L, Gomez-Dominguez M, Prado Gasco V, Valero Moreno S. Frontiers in Psychology. 2020 Mar 13;11:295. doi: 10.3389/fpsyg.2020.00295. PMID: 32231608

Immunofluorescence Analysis as a Diagnostic Tool in a Spanish Cohort of Patients with Suspected Primary Ciliary Dyskinesia. Baz-Redon N, Rovira-Amigo S, Fernandez-Cancio M, Castillo Corullon S, Cols M, Caballero-Rabasco M, Asensio O, Martin de Vicente C, Martinez-Colls M, Torrent-Vernetta A, de Mir-Messa I, Gartner S, Iglesias-Serrano I, Diez-Izquierdo A, Polverino E, Amengual-Pieras E, Amaro-Rodriguez R, Vendrell M, Mumany M, Pascual-Sanchez M, Perez-Duenas B, Reula Martin A, Escribano Montaner A, Dasí Fernández F, Armengot Carceller M, Garrido-Pontnou M, Camats-Tarruella N, Moreno-Galdo A. Journal of Clinical Medicine. 2020 Nov 9;9(11):3603. doi: 10.3390/jcm9113603. PMID: 33182294

Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: Incidence and results of the national CF-COVID19-Spain survey. Mondejar-Lopez P, Quintana-Gallego E, Giron-Moreno R, Cortell-Aznar I, Ruiz de Valbuena-Maiz M, Diab-Caceres L, Prados-Sanchez C, Alvarez-Fernandez A, Garcia-Marcos P, Penalver-Mellado C, Dolores Pastor-Vivero M, Olveira C, Lopez-Neyra A, Castillo Corullon S, Palma-Milla S, Perez-Ruiz E, Sole-Jover A, Isabel Barrio M, Sanchez-Solis M, Asensio de la Cruz O, CF-COVID19-Spain Registry Grp. Respiratory Medicine. 2020;170:106062. doi: 10.1016/j.rmed.2020.106062. PMID: 32843180

Knowledge of Rare Respiratory Diseases among Paediatricians and Medical School Students. Requena-Fernandez MA, Dasí Fernández F, Castillo Corullon S, Barajas Cenobio S, Navarro García M, Escribano Montaner A. Journal of Clinical Medicine. 2020 Mar 22;9(3):869. doi: 10.3390/jcm9030869. PMID: 32235794

miR-320c Regulates SERPINA1 Expression and Is Induced in Patients With Pulmonary Disease. Matamala N, Lara B, Gomez Mariano G, Martinez S, Vazquez Dominguez I, Otero Sobrino A, Munoz Callejas A, Sanchez E, Esquinas C, Bustamante A, Cadenas S, Curi S, Lazaro L, Martinez MT, Rodriguez E, Miravitlles M, Torres Duran M, Herrero I, Michel FJ, Castillo S, Hernandez Perez JM, Blanco I, Casas F, Martinez Delgado B. Archivos de Bronconeumologia. 2020 May 18;S0300-2896(20)30084-3. doi: 10.1016/j.arbres.2020.03.006. PMID: 32439252

Primary ciliary dyskinesia and psychological well-being in adolescence. Valero Moreno S, Castillo Corullon S, Montoya Castilla I, Perez Marin M. PLoS One. 2020 Jan 23;15(1):e0227888. doi: 10.1371/journal.pone.0227888. PMID: 31971980

Psychometric properties of the questionnaire on threat perception of chronic illnesses in pediatric patients. Valero Moreno S, Lacomba Trejo L, Casana-Granell S, Prado Gasco V, Montoya Castilla I, Perez Marin M. Revista Latino-Americana de Enfermagem. 2020 Feb 3;28:e3242. doi: 10.1590/1518-8345.3144.3242. PMID: 32022154

Psychosocial factors and chronic illness as predictors for anxiety and depression in adolescence. Lacomba Trejo L, Valero Moreno S, Montoya Castilla I, Perez Marin M. Frontiers in Psychology. 2020 Sep 18;11:568941. doi: 10.3389/fpsyg.2020.568941. PMID: 33071898

Pulmonary function testing in children’s interstitial lung disease. Ring A, Carlens J, Bush A, Castillo Corullon S, Fasola S, Gaboli M, Griese M, Koucky V, La Grutta S, Lombardi E, Proesmans M, Schwerk N, Snijders D, Nielsen K, Buchvald F. European Respiratory Review. 2020 Jul 21;29(157):200019. doi: 10.1183/16000617.0019-2020. PMID: 32699025

Repeated Aspiration Pneumonia in a 7-Year-Old Girl With Undiagnosed Congenital Tracheoesophageal Fistula. Piolatti Luna A, Castillo Corrullon S. Archivos de Bronconeumologia. 2020 Jul 1;S0300-2896(20)30191-5. doi: 10.1016/j.arbres.2020.05.033. PMID: 32622481

Projects
Reference:
Title: Circulating miRNAs as potential prognostic biomarkers in alpha-1 antitrypsin deficiency. A Functional approach
Funding body: Grifols SA
Principal Investigator: Silvia Castillo Corullón
Duration: 2019 – 2020
Total budget: 50.000 €
Reference: PI17/01250
Title: Estudio del efecto de la hipoxia en la degranulación, producción de citoquinas y perfil oxidativo de neutrófilos de pacientes con déficit de alfa-1 antitripsina
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Francisco Dasí Fernández
Duration: 2018 – 2021
Total budget: 99.220 €
Reference: COST Action CA16125
Title: European network for translational research in children’s and adult interstitial lung disease
Funding body: European Commission. FP7 Marie Curie Actions
Principal Investigator: Antonio Moreno
Duration: 2016 – 2019
Total budget:
+ Info
Title: Efecto de la hipoxia en la degranulación, producción de citoquinas y perfil oxidativo de neutrófilos en pacientes con déficit de alfa-1 antitripsina
Doctoral candidate: Magallón Serrano, María
Director(s): Dasí Fernández, Francisco
Date of the defense: 01/12/2022
University: Universitat de València

Title: Edición génica del gen serpina1 mediante el uso de CRISPR/CAS9 en células sanguíneas de pacientes con déficit de alfa-1 antitripsina
Doctoral candidate: Bañuls Soto, Lucía
Director(s): Dasí Fernández, Francisco; Escribano Montaner, Amparo; Martí Pérez, Salvador
Date of the defense: 20/05/2022
University: Universitat de València

Title: Valor pronóstico del estudio del perfil de miRNAs en la Neumonía Adquirida en la Comunidad
Doctoral candidate: Vicente Ferrer, Silvia
Director(s): Fernández Fabrellas, Estrella; Sanz Herrero, Francisco; Dasí Fernández, Francisco Jose
Date of the defense: 07/05/2021
University: Universitat de València

Title: Repercusiones psicológicas de la enfermedad respiratoria crónica pediátrica en los pacientes y en sus cuidadores
Doctoral candidate: Valero Moreno, Selene
Director(s): Pérez Marín, Mª Antonia; Montoya Castilla, Inmaculada
Date of the defense: 08/02/2021
University: Universitat de València