Grupo de investigación en Enfermedades Raras Respiratorias (ERR)

Área de Metabolismo y Daño Orgánico

Hemos demostrado que NK y linfocitos B expresan y secretan alfa-1 antitripsina

Hemos descubierto un grupo de miARN que podrían usarse para el diagnóstico y pronóstico de la deficiencia de alfa-1 antitripsina. Actualmente estamos validando estos resultados utilizando una cohorte externa

Se ha puesto en marcha un nuevo método basado en marcadores de estrés oxidativo para identificar a los pacientes con discinesia ciliar primaria

Hemos configurado el método de video de alta velocidad para identificar pacientes con discinesia ciliar primaria

Hemos demostrado que la hipoxia modifica la desgranulación de los neutrófilos y aumenta el daño oxidativo en pacientes con deficiencia de alfa-1 antitripsina

Dr. Francisco Dasí Fernández
Coordinador
Dr. Francisco Dasí Fernández
francisco.dasi@uv.es  

INVESTIGADORES
R4 Senior
R3 Consolidado

Selene Valero Moreno
Francisco Dasí Fernández    

R2 Novel / Emergente

María Magallón Serrano
Silvia Castillo Corullón

R1 Predoctoral

Daniel Pellicer Roig

STAFF
Colaborador/a
Enfermero/a
Técnico/a

Miguel Ángel Esteve Gimeno
Néstor Navarro Ortí

Apoyo
Publicaciones
Alpha-1 antitrypsin deficiency. Dasi F. Medicina Clinica. 2023 Mar 10;160(5):203-205. doi: 10.1016/j.medcli.2022.09.001. PMID: 36253208

Compassion in Spanish-speaking health care: a systematic review. Zaragoza A, Soto-Rubio A, Lacomba-Trejo L, Valero-Moreno S, Perez-Marin M. Current Psychology. 2023;42(8):6732-6751. doi: 10.1007/s12144-021-01994-z. PMID: 34220172

Diffuse alveolar haemorrhage in children: an international multicentre study. Ring A, Schwerk N, Kiper N, Aslan A, Aurora P, Ayats R, Azevedo I, Bandeira T, Carlens J, Castillo-Corullon S, Cobanoglu N, Elnazir B, Emiralioglu N, Eyuboglu T, Fayon M, Gursoy T, Hogg C, Kotz K, Karadag B, Latalova V, Krenke K, Lange J, Manali E, Osona B, Papiris S, Proesmann M, Reix P, Roditis L, Rubak S, Rumman N, Snijders D, Stehling F, Weiss L, Yalcin E, Zirek F, Bush A, Clement A, Griese M, Buchvald F, Nathan N, Nielsen K. ERJ Open Research. 2023 Apr 24;9(2):00733-2022. doi: 10.1183/23120541.00733-2022. PMID: 37101741

Family styles and quality of life in adolescents with bronchial asthma: The important role of self-esteem and perceived threat of the disease. Valero-Moreno S, Montoya-Castilla I, Perez-Marin M. Pediatric Pulmonology. 2023 Jan;58(1):178-186. doi: 10.1002/ppul.26178. PMID: 36193795

Hypoxia enhances oxidative stress in neutrophils from ZZ Alpha-1 antitrypsin deficiency patients. Magallon M, Castillo-Corullon S, Banuls L, Pellicer D, Romero T, Martinez-Ferraro C, Navarro-Garcia M, Herrejon A, Gonzalez C, Dasi F. Antioxidants. 2023 Apr 3;12(4):872. doi: 10.3390/antiox12040872. PMID: 37107247

Quality of life in patients with asthma: Medical indicators and psychological variables. Valero-Moreno S, Montoya-Castilla I, Perez-Marin M. Journal of Pediatric Nursing. 2023 Mar-Apr;69:e136-e144. doi: 10.1016/j.pedn.2022.12.030. PMID: 36609027

Response to the letter to the editor Alpha-1 antitrypsin deficiency: impact of its relevance in hematology. Dasi F. Medicina Clinica. 2023 Oct 11:S0025-7753(23)00528-6. doi: 10.1016/j.medcli.2023.08.005. PMID: 37833107

Study of the emotional adjustment of the caregiver-patient dyad to bronchial asthma in adolescence. Valero-Moreno S, Montoya-Castilla I, Perez-Marin M. International Journal of Nursing Practice. 2023 Jun 4;e13171. doi: 10.1111/ijn.13171. PMID: 37271579

Benefits of a support programme for family caregivers of patients at the end of life: A randomised controlled trial. Soto Rubio A, Valero Moreno S, Perez Marin M. Journal of Health Psychology. 2022 Jan;27(1):199-210. doi: 10.1177/1359105320944993. PMID: 32772853

Cross-cultural validation of the Worries about COVID-19 and its consequences Scale (W-COV) in adolescents and young people. Monaco E, Schoeps K, Valero-Moreno S, Castro-Calvo J, Montoya-Castilla I, del Rosario C, Coello F, Herrera S, Trujillo A, Munevar F, Esparza NA. Archives of Psychiatric Nursing. 2022 Oct;40:158-166. doi: 10.1016/j.apnu.2022.07.016. PMID: 36064240

Do COVID-19 worries, resilience and emotional distress influence life satisfaction? outcomes in adolescents in Ecuador during the Pandemic: SEM vs. QCA. Herrera J, Lacomba-Trejo L, Valero-Moreno S, Montoya-Castilla I, Perez-Marin M. Children. 2022 Mar 21;9(3):439. doi: 10.3390/children9030439. PMID: 35327811

Emotional IMPACT IN ADOLESCENTS in Ecuador Six Months After The Beginning of the COVID-19 Pandemic. Coello M, Valero-Moreno S, Herrera J, Lacomba-Trejo L, Perez-Marin M. Journal of Psychology. 2022;156(5):381-394. doi: 10.1080/00223980.2022.2054921. PMID: 35482962

Geographic distribution and phenotype of European people with cystic fibrosis carrying A1006E mutation. Mondejar-Lopez P, Zolin A, Garcia-Marcos P, Pastor-Vivero M, Rosa-Silvestre M, Sanchez-Martinez F, Salvatore D, Cimino G, Majo F, Sole-Jover A, de la Cruz O, Calderazzo M, Pizzamiglio G, Castillo-Corullon S, Alvarez-Fernandez A, Gartner S, Padoan R, Carnovale V, Salvatore M, Moya-Quiles M, Orenti A, Glover G, Sanchez-Solis M. Respiratory Medicine. 2022 Feb;192:106736. doi: 10.1016/j.rmed.2022.106736. PMID: 35032736

Incidence and prevalence of children’s diffuse lung disease in Spain. Torrent-Vernetta A, Gaboli M, Castillo-Corullon S, Mondejar-Lopez P, Santiago V, Costa-Colomer J, Osona B, Torres-Borrego J, De la Serna-Blazquez O, Alonso S, Aguilera P, De Atauri A, Soria A, Ayats R, de Vicente C, Gonzalez V, Gonzalez J, Calderin E, Pastor-Vivero M, Alvarez M, Rovira-Amigo S, Serrano I, Izquierdo A, Messa I, Gartner S, Navarro A, Baz-Redon N, Carmona R, Camats-Tarruella N, Fernandez-Cancio M, Rapp C, Dopazo J, Griese M, Moreno-Galdo A. Archivos de Bronconeumologia. 2022 Jan;58(1):22-29. doi: 10.1016/j.arbres.2021.06.001. PMID: 35249699

Longitudinal analysis of adolescent adjustment: the role of attachment and emotional competence. Jimenez-Rodriguez T, De la Barrera U, Schoeps K, Valero-Moreno S, Montoya-Castilla I. Children. 2022 Nov 8;9(11):1711. doi: 10.3390/children9111711. PMID: 36360439

Perceived stress in the primary caregivers of adolescents with asthma: a cross-sectional study. Valero-Moreno S, Montoya-Castilla I, Schoeps K, Postigo-Zegarra S, Perez-Marin M. Children. 2022 Oct 25;9(11):1614. doi: 10.3390/children9111614. PMID: 36360342

Predicting health-related quality of life in Spanish adolescents with allergic rhinoconjunctivitis and bronchial asthma. Lacomba-Trejo L, Valero-Moreno S, Montoya-Castilla I, Marin M. Psychology Health & Medicine. 2022 Mar;27(3):613-625. doi: 10.1080/13548506.2021.1904514. PMID: 33759655

Psychological aspects of pre-adolescents or adolescents with precocious puberty: a systematic review. Lopez-Miralles M, Lacomba-Trejo L, Valero-Moreno S, Benavides G, Perez-Marin M. Journal of Pediatric Nursing. 2022 May-Jun;64:e61-e68. doi: 10.1016/j.pedn.2022.01.002. PMID: 35033399

Teachers’ response to stress, anxiety and depression during COVID-19 lockdown: what have we learned from the pandemic?. Lacomba-Trejo L, Schoeps K, Valero-Moreno S, Del Rosario C, Montoya-Castilla I. Journal of School Health. 2022 Sep;92(9):864-872. doi: 10.1111/josh.13192. PMID: 35610141

The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN. Raidt J, Maitre B, Pennekamp P, Altenburg J, Anagnostopoulou P, Armengot M, Bloemsma L, Boon M, Borrelli M, Brinkmann F, Carr S, Carroll M, Castillo-Corullon S, Coste A, Cutrera R, Dehlink E, Destouches D, Di Cicco M, Dixon L, Emiralioglu N, Eralp E, Haarman E, Hogg C, Karadag B, Kobbernagel H, Lorent N, Mall M, Marthin J, Martinu V, Narayanan M, Ozcelik U, Peckham D, Pifferi M, Pohunek P, Polverino E, Range S, Ringshausen F, Robson E, Roehmel J, Rovira-Amigo S, Santamaria F, Schlegtendal A, Szepfalusi Z, Tempels P, Thouvenin G, Ullmann N, Walker W, Wetzke M, Yiallouros P, Omran H, Nielsen K. ERJ Open Research. 2022 Aug 15;8(3):00139-2022. doi: 10.1183/23120541.00139-2022. PMID: 35983540

The relation of CFTR-genotype and associated comorbidities to development of pulmonary atelectasis in cystic fibrosis patients. Martinez-Redondo M, Prados Sanchez C, Garcia-Rio F, Quintana Gallego E, Castillo Corullon S, Salcedo Posadas A, Giron Moreno R, Martinez Martinez M, Maiz Carro L, de Vicente C, Costa Colomer J, Alvarez-Sala Walther R. Archivos de Bronconeumologia. 2022 Sep;58(9):666-668. doi: 10.1016/j.arbres.2022.02.009. PMID: 35644710

Clinically amyopathic dermatomyositis with pulmonary involvement, exceptional pathology. Navio Anaya M, Monrabal Bernabeu A, Pons Morales S, Castillo Corullon S. Anales de Pediatria. 2021 Oct;95(4):282-283. doi: 10.1016/j.anpedi.2020.11.029. PMID: 33478851

Comparison of physical activity and sedentary behaviour between schoolchildren with cystic fibrosis and healthy controls: a gender analysis. Valencia-Peris A, Lizandra J, Moya-Mata I, Gomez-Gonzalvo F, Castillo-Corullon S, Escribano A. International Journal of Environmental Research and Public Health. 2021 May 18;18(10):5375. doi: 10.3390/ijerph18105375. PMID: 34070042

Empirically supported psychological treatments for children and adolescents: state of the art. Fonseca-Pedrero E, Perez-Alvarez M, Al-Halabi S, et al. Psicothema. 2021 Aug;33(3):386-398. doi: 10.7334/psicothema2021.56. PMID: 34297668

Implementation of a Gene Panel for Genetic Diagnosis of Primary Ciliary Dyskinesia. Baz-Redon N, Rovira-Amigo S, Paramonov I, Castillo Corullon S, Cols Roig M, Antolin M, Garcia Arumi E, Torrent-Vernetta A, De Mir Messa I, Gartner S, Iglesias Serrano I, Caballero-Rabasco M, Asensio De La Cruz O, Vizmanos-Lamotte G, Martin De Vicente C, Martinez-Colls M, Reula Martin A, Escribano Montaner A, Dasí Fernández F, Armengot Carceller M, Polverino E, Amengual Pieras E, Amaro-Rodriguez R, Garrido-Pontnou M, Tizzano E, Camats-Tarruella N, Fernandez-Cancio M, Moreno-Galdo A. Archivos de Bronconeumologia. 2021 Mar;57(3):186-194. doi: 10.1016/j.arbres.2020.02.010. PMID: 32253119

Is mHealth a useful therapy for improving physical or emotional health in adolescents with cystic fibrosis? a systematic review. Valero-Moreno S, Lacomba-Trejo L, Montoya-Castilla I, Perez-Marin M. Current Psychology. 2021 Nov 24;1-14. doi: 10.1007/s12144-021-02452-6. PMID: 34840486

Methodologies for the determination of blood Alpha1 antitrypsin levels: a systematic review. Ruiz-Duque B, Banuls L, Reinoso-Arija R, Carrasco-Hernandez L, Caballero-Eraso C, Dasi F, Lopez-Campos JL. Journal of Clinical Medicine. 2021 Oct 31;10(21):5132. doi: 10.3390/jcm10215132. PMID: 34768650

New laboratory protocol to determine the oxidative stress profile of human nasal epithelial cells using flow cytometry. Reula A, Pellicer D, Castillo S, Magallon M, Armengot M, Herrera G, O’Connor J, Banuls L, Navarro-Garcia M, Escribano A, Dasi F. Journal of Clinical Medicine. 2021 Mar 11;10(6):1172. doi: 10.3390/jcm10061172. PMID: 33799667

Oxidative stress and endoplasmic reticulum stress in rare respiratory diseases. Magallon M, Carrion A, Banuls L, Pellicer D, Castillo S, Bondia S, Navarro-Garcia M, Gonzalez C, Dasi F. Journal of Clinical Medicine. 2021 Mar 18;10(6):1268. doi: 10.3390/jcm10061268. PMID: 33803835

Predictors of complicated grief in mourners of sudden cardiac death. Soto-Rubio A, Valero-Moreno S, Perez-Marin M. American Journal of Emergency Medicine. 2021 Dec;50:797-798. doi: 10.1016/j.ajem.2021.03.028. PMID: 33741200

Prevention of teratogenesis in pregnancies of obese rats by vitamin E supplementation. Alcala M, Bolado V, Sanchez-Vera I, Clapes S, Dasi F, Saez G, Carrera E, Alvarez-Gallego F, Loeken M, Viana M. Antioxidants. 2021 Jul 23;10(8):1173. doi: 10.3390/antiox10081173. PMID: 34439421

Psycho-emotional adjustment in parents of adolescents: A cross-sectional and longitudinal analysis of the impact of the COVID pandemic. Valero-Moreno S, Lacomba-Trejo L, Tamarit A, Perez-Marin M, Montoya-Castilla I. Journal of pediatric nursing. 2021;59:e44-e51. doi: 10.1016/j.pedn.2021.01.028. PMID: 33608182

Repeated aspiration pneumonia in a 7-year-old girl with undiagnosed congenital tracheoesophageal fistula. Piolatti-Luna A, Castillo-Corrullon S. Archivos de Bronconeumologia. 2021 Aug;57(8):545. doi: 10.1016/j.arbr.2021.05.015. PMID: 34147349

Attitudes, Sentiments, and Concerns About Inclusive Education of Teachers and Teaching Students in Spain. Navarro-Mateu D, Franco-Ochoa J, Valero Moreno S, Prado Gasco V. Frontiers in Psychology. 2020 Apr 7;11:521. doi: 10.3389/fpsyg.2020.00521. PMID: 32318002

Childhood adaptation: perception of the parenting style and the anxious-depressive symptomatology. Schoeps K, Valero Moreno S, Perona A, Perez Marin M, Montoya Castilla I. Journal for Specialists in Pediatric Nursing. 2020 Oct;25(4):e12306. doi: 10.1111/jspn.12306. PMID: 32762136

COPD at the end of life: predictors of the emotional distress of patients and their family caregivers. Soto-Rubio A, Valero Moreno S, Diaz Cordobes J, Andreu Y, Perez Marin M. PLoS One. 2020 Oct 16;15(10):e0240821. doi: 10.1371/journal.pone.0240821. PMID: 33064747

Gene Therapy in Rare Respiratory Diseases: What Have We Learned So Far?. Bañuls Soto L, Pellicer Roig D, Castillo Corullon S, Navarro García M, Magallón Serrano M, González C, Dasí Fernández F. Journal of Clinical Medicine. 2020 Aug 8;9(8):2577. doi: 10.3390/jcm9082577. PMID: 32784514

I’m Not Good for Anything and That’s Why I’m Stressed: Analysis of the Effect of Self-Efficacy and Emotional Intelligence on Student Stress Using SEM and QCA. Navarro-Mateu D, Alonso-Larza L, Gomez-Dominguez M, Prado Gasco V, Valero Moreno S. Frontiers in Psychology. 2020 Mar 13;11:295. doi: 10.3389/fpsyg.2020.00295. PMID: 32231608

Immunofluorescence Analysis as a Diagnostic Tool in a Spanish Cohort of Patients with Suspected Primary Ciliary Dyskinesia. Baz-Redon N, Rovira-Amigo S, Fernandez-Cancio M, Castillo Corullon S, Cols M, Caballero-Rabasco M, Asensio O, Martin de Vicente C, Martinez-Colls M, Torrent-Vernetta A, de Mir-Messa I, Gartner S, Iglesias-Serrano I, Diez-Izquierdo A, Polverino E, Amengual-Pieras E, Amaro-Rodriguez R, Vendrell M, Mumany M, Pascual-Sanchez M, Perez-Duenas B, Reula Martin A, Escribano Montaner A, Dasí Fernández F, Armengot Carceller M, Garrido-Pontnou M, Camats-Tarruella N, Moreno-Galdo A. Journal of Clinical Medicine. 2020 Nov 9;9(11):3603. doi: 10.3390/jcm9113603. PMID: 33182294

Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: Incidence and results of the national CF-COVID19-Spain survey. Mondejar-Lopez P, Quintana-Gallego E, Giron-Moreno R, Cortell-Aznar I, Ruiz de Valbuena-Maiz M, Diab-Caceres L, Prados-Sanchez C, Alvarez-Fernandez A, Garcia-Marcos P, Penalver-Mellado C, Dolores Pastor-Vivero M, Olveira C, Lopez-Neyra A, Castillo Corullon S, Palma-Milla S, Perez-Ruiz E, Sole-Jover A, Isabel Barrio M, Sanchez-Solis M, Asensio de la Cruz O, CF-COVID19-Spain Registry Grp. Respiratory Medicine. 2020;170:106062. doi: 10.1016/j.rmed.2020.106062. PMID: 32843180

Knowledge of Rare Respiratory Diseases among Paediatricians and Medical School Students. Requena-Fernandez MA, Dasí Fernández F, Castillo Corullon S, Barajas Cenobio S, Navarro García M, Escribano Montaner A. Journal of Clinical Medicine. 2020 Mar 22;9(3):869. doi: 10.3390/jcm9030869. PMID: 32235794

miR-320c Regulates SERPINA1 Expression and Is Induced in Patients With Pulmonary Disease. Matamala N, Lara B, Gomez Mariano G, Martinez S, Vazquez Dominguez I, Otero Sobrino A, Munoz Callejas A, Sanchez E, Esquinas C, Bustamante A, Cadenas S, Curi S, Lazaro L, Martinez MT, Rodriguez E, Miravitlles M, Torres Duran M, Herrero I, Michel FJ, Castillo S, Hernandez Perez JM, Blanco I, Casas F, Martinez Delgado B. Archivos de Bronconeumologia. 2020 May 18;S0300-2896(20)30084-3. doi: 10.1016/j.arbres.2020.03.006. PMID: 32439252

Primary ciliary dyskinesia and psychological well-being in adolescence. Valero Moreno S, Castillo Corullon S, Montoya Castilla I, Perez Marin M. PLoS One. 2020 Jan 23;15(1):e0227888. doi: 10.1371/journal.pone.0227888. PMID: 31971980

Psychometric properties of the questionnaire on threat perception of chronic illnesses in pediatric patients. Valero Moreno S, Lacomba Trejo L, Casana-Granell S, Prado Gasco V, Montoya Castilla I, Perez Marin M. Revista Latino-Americana de Enfermagem. 2020 Feb 3;28:e3242. doi: 10.1590/1518-8345.3144.3242. PMID: 32022154

Psychosocial factors and chronic illness as predictors for anxiety and depression in adolescence. Lacomba Trejo L, Valero Moreno S, Montoya Castilla I, Perez Marin M. Frontiers in Psychology. 2020 Sep 18;11:568941. doi: 10.3389/fpsyg.2020.568941. PMID: 33071898

Pulmonary function testing in children’s interstitial lung disease. Ring A, Carlens J, Bush A, Castillo Corullon S, Fasola S, Gaboli M, Griese M, Koucky V, La Grutta S, Lombardi E, Proesmans M, Schwerk N, Snijders D, Nielsen K, Buchvald F. European Respiratory Review. 2020 Jul 21;29(157):200019. doi: 10.1183/16000617.0019-2020. PMID: 32699025

Repeated Aspiration Pneumonia in a 7-Year-Old Girl With Undiagnosed Congenital Tracheoesophageal Fistula. Piolatti Luna A, Castillo Corrullon S. Archivos de Bronconeumologia. 2020 Jul 1;S0300-2896(20)30191-5. doi: 10.1016/j.arbres.2020.05.033. PMID: 32622481

Proyectos
Referencia: PI17/01250
Título: Estudio del efecto de la hipoxia en la degranulación, producción de citoquinas y perfil oxidativo de neutrófilos de pacientes con déficit de alfa-1 antitripsina
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Francisco Dasí Fernández
Duración: 2018 – 2021
Presupuesto: 99.220 €
Referencia: COST Action CA16125
Título: European network for translational research in children’s and adult interstitial lung disease
Entidad Financiadora: European Commission. FP7 Marie Curie Actions
Investigador principal: Antonio Moreno
Duración: 2016 – 2019
Presupuesto:
+ Información
Título: Efecto de la hipoxia en la degranulación, producción de citoquinas y perfil oxidativo de neutrófilos en pacientes con déficit de alfa-1 antitripsina
Doctorando: Magallón Serrano, María
Director: Dasí Fernández, Francisco
Fecha: 01/12/2022
Universidad: Universitat de València

Título: Estudio de la utilidad clínica de los microarns en suero y orina de pacientes con cáncer de vejiga
Doctorando: Castelló Porcar, Ana María
Director: Dasi Fernandez, Francisco Jose; Martínez Jabaloyas, Jose M
Fecha: 27/10/2022
Universidad: Universitat de València

Título: Edición génica del gen serpina1 mediante el uso de CRISPR/CAS9 en células sanguíneas de pacientes con déficit de alfa-1 antitripsina
Doctorando: Bañuls Soto, Lucía
Director: Dasí Fernández, Francisco; Escribano Montaner, Amparo; Martí Pérez, Salvador
Fecha: 20/05/2022
Universidad: Universitat de València

Título: Valor pronóstico del estudio del perfil de miRNAs en la Neumonía Adquirida en la Comunidad
Doctorando: Vicente Ferrer, Silvia
Director: Fernández Fabrellas, Estrella; Sanz Herrero, Francisco; Dasí Fernández, Francisco Jose
Fecha: 07/05/2021
Universidad: Universitat de València

Título: Repercusiones psicológicas de la enfermedad respiratoria crónica pediátrica en los pacientes y en sus cuidadores
Doctorando: Valero Moreno, Selene
Director: Pérez Marín, Mª Antonia; Montoya Castilla, Inmaculada
Fecha: 08/02/2021
Universidad: Universitat de València