Research Group on Aging and Physical Activity
Metabolism and Organic Damage Area
Regenerative medicine in aging
Identification of physical training as a drug to treat age-related frailty
Prove that G6PD protects against oxidative damage and improves lifespan in mice
Reducing stress: a new concept in disease Alzheimer’s
Coordinator
STAFF
Collaborating Researchers
Nurse
Technicians
Administrative assistant
Cristina Amézcua García
Publications
Glucose 6-P dehydrogenase overexpression improves aging-induced endothelial dysfunction in aorta from mice: role of arginase II. Serna E, Mauricio MD, San Miguel T, Guerra Ojeda S, Verdu D, Valls A, Arc-Chagnaud C, De la Rosa A, Vina J. International Journal of Molecular Sciences. 2023 Feb 11;24(4):3622. doi: 10.3390/ijms24043622. PMID: 36835034
Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome. Sol J, Obis E, Mota Martorell N, Pradas I, Galo Licona J, Martin Gari M, Fernandez Bernal A, Ortega Bravo M, Mayneris Perxachs J, Borras C, Vina J, de la Fuente M, Mate I, Biarnes C, Pedraza S, Vilanova J, Brugada R, Ramos R, Serena J, Ramio-Torrenta L, Pineda V, Daunis I Estadella P, Thio Henestrosa S, Barretina J, Garre Olmo J, Portero Otin M, Fernandez Real J, Puig J, Jove M, Pamplona R. Aging Cell. 2023 Mar 23;e13821. doi: 10.1111/acel.13821. PMID: 36951231
Systematic review of brain and blood lipidomics in Alzheimer’s disease mouse models. Ferre Gonzalez L, Lloret A, Chafer Pericas C. Progress in Lipid Research. 2023 Mar 5;90:101223. doi: 10.1016/j.plipres.2023.101223. PMID: 36871907
Analysis of exosomal cargo provides accurate clinical, histologic and mutational information in non-small cell lung cancer. Durendez-Saez E, Calabuig-Farinas S, Torres-Martinez S, Moreno-Manuel A, Herreros-Pomares A, Escorihuela E, Mosqueda M, Gallach S, Guijarro R, Serna E, Suarez-Cabrera C, Paramio J, Blasco A, Camps C, Jantus-Lewintre E. Cancers. 2022 Jun 30;14(13):3216. doi: 10.3390/cancers14133216. PMID: 35804987
Blood DNA methylation patterns in older adults with evolving dementia. Fernandez Perez R, Alba Linares JJ, Tejedor JR, Fernandez Fernandez A, Calero M, Roman Dominguez A, Borras C, Vina J, Avila J, Medina M, Fernandez Fraga M. The journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Sep 1;77(9):1743-1749. doi: 10.1093/gerona/glac068. PMID: 35299244
Effects of GH on the aging process in several organs: mechanisms of actio. Tresguerres J, Fernandez-Tresguerres I, Vina J, Rancan L, Paredes S, Linillos-Pradillo B, Vara E. International Journal of Molecular Sciences. 2022 Jul 16;23(14):7848. doi: 10.3390/ijms23147848. PMID: 35887196
Exercise training as a modulator of epigenetic events in prostate tumors. Dufresne S, Gueritat J, Wong CP, Isanejad A, Ho E, Serna E, Gomez-Cabrera MC, Rebillard A. Prostate Cancer and Prostatic Diseases. 2022 Mar;25(1):119-122. doi: 10.1038/s41391-021-00380-x. PMID: 34007020
Adolescent binge-ethanol accelerates cognitive impairment and beta-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. Carlos Ledesma J, Rodriguez-Arias M, Gavito A, Sanchez-Perez A, Viña Ribes J, Medina Vera D, Rodriguez De Fonseca F, Minarro J. Addiction Biology. 2021 Jan;26(1):e12883. doi: 10.1111/adb.12883. PMID: 32043730
Aerobic exercise during advance stage of uncontrolled arterial hypertension. Pagan LU, Gomes MJ, Damatto RL, Lima Aline RR, Cezar MDM, Damatto FC, Reyes DRA, Campos DHS, Caldonazo TMM, Polegato BF, Fernandes DC, Laurindo FR, Fernandes AAH, Lloret A, Cicogna AC, Okoshi MP, Okoshi K. Frontiers in Physiology. 2021 Jun 3;12:675778. doi: 10.3389/fphys.2021.675778. PMID: 34149455
Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395
Diagnostic performance of muscle echo intensity and fractal dimension for the detection of frailty phenotype. Miron Mombiela R, Vucetic J, Monllor P, Cardenas-Herran JS, Taltavull de la Paz P, Borras C. Ultrasonic Imaging. 2021 Nov;43(6):337-352. doi: 10.1177/01617346211029656. PMID: 34238072
Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators. Serna E, Cespedes C, Vina J. International Journal of Molecular Sciences. 2020 Dec 31;22(1):374. doi: 10.3390/ijms22010374. PMID: 33396477
BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. Borras Blasco C, Mas Bargues C, Roman-Dominguez A, Sanz Ros J, Gimeno Mallench L, Inglés De La Torre M, Gambini Buchon J, Viña Ribes J. International Journal of Molecular Sciences. 2020 Jan 9;21(2):418. doi: 10.3390/ijms21020418. PMID: 31936510
Centenarians: An excellent example of resilience for successful ageing. Borras Blasco C, Inglés De La Torre M, Mas Bargues C, Dromant M, Sanz Ros J, Roman-Dominguez A, Gimeno Mallench L, Gambini Buchon J, Viña Ribes J. Mechanisms of Ageing and Development. 2020 Mar;186:111199. doi: 10.1016/j.mad.2019.111199. PMID: 31899226
Early reductive stress and late onset overexpression of antioxidant enzymes in experimental myocardial infarction. Carretero Martínez A, Gomez Cabrera M, Rios Navarro C, Salvador Pascual A, Bodí Peris V, Viña Ribes J. Free Radical Research. 2020 Mar;54(2-3):173-184. doi: 10.1080/10715762.2020.1735632. PMID: 32103692
Projects
Title: Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK of protein energy malnutrition in pre-dementia AGEd people. ERA-HDHL Call for Joint Transnational Research Proposals on Development of targeted nutrition for prevention of undernutrition for older adults (PREVNUT)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Viña Ribes
Duration: 2021 – 2023
Total budget: 169.098 €
Title: Diferencias de fragilidad entre generos: Evaluación de biomarcadores y estrategias de intervención
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: José Viña Ribes
Duration: 2020 – 2023
Total budget: 189.391 €
Title: Nuevas intervenciones terapéuticas multidominio para retrasar la fragilidad y la discapacidad. Identificación de mecanismos moleculares con relevancia traslacional (Mitofrail)
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: José Viña Ribes, Mª Carmen Gómez Cabrera
Duration: 2020 – 2023
Total budget: 270.000 €
Title: Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmerica
Funding body: European Commission
Principal Investigator: José Viña Ribes
Duration: 2019 – 2024
Total budget: 273.720 €
Title: Estudio de la fragilidad cognitiva y su transición a la demencia mediante un conjunto de biomarcadores en sangre periférica. Intervención con genisteína
Funding body: Fundación General del Consejo Superior de Investigaciones Científicas (FGCSIC)
Principal Investigator: José Viña Ribes
Duration: 2018 – 2019
Total budget: 39.940 €
Title: CIBER de Fragilidad y Envejecimiento (CIBERFES)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Viña Ribes
Duration: 2017 –
Total budget:
Title: Managing Frailty. A comprehensive approach to promote a disability-free advanced age in Europe: the ADVANTAGE initiative
Funding body: European Commission (3rd Health Program)
Principal Investigator: Josep Redón i Mas, José Viña Ribes
Duration: 2016 – 2019
Total budget: 130.005 €
Title: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicente Bodí Peris
Duration: 2016 – 2019
Total budget: 589.050 €
Title: Envejecimiento cerebral: protección contra el daño asociado al mismo y su aplicación a la enfermedad de Alzheimer
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: José Viña Ribes
Duration: 2016 – 2019
Total budget: 169.400 €
+ Info
Doctoral candidate: Millán Domingo, Fernando
Director(s): Viña Ribes, José; Gómez Cabrera, María Carmen; Tarazona Santabalbina, Francisco José
Date of the defense: 01/07/2022
University: Universitat de València
Title: Papel de la xantina oxidasa en la pérdida de masa muscular por inmovilización en humanos. Importancia del protocolo de obtención de biopsias musculares en los estudios de atrofia muscular
Doctoral candidate: Sebastiá Alcàcer, Vicente
Director(s): Gómez Cabrera, Mª Carmen; Viña Ribes, José; Viosca Herrero, Enrique
Date of the defense: 28/06/2022
University: Universitat de València
Title: Análisis de la anchura de la cortical vestibular en dientes anteriores maxilares y en la planificación virtual de implantes mediante tomografías computarizadas de hazcónico
Doctoral candidate: Rojo Sanchis, Julio
Director(s): Peñarrocha Oltra, David; Viña Almunia, Jose
Date of the defense: 30/04/2021
University: Universitat de València
Title: Influencia del procesamiento de la leche humana donada sobre la microbiota intestinal, la expresión genómica y el equilibrio oxidativo en recién nacidos pretérmino menores de 32 semanas de edad gestacional
Doctoral candidate: Parra Llorca, Anna
Director(s): Vento, Máximo; Collado Amores, María Carmen; Serna García, Eva
Date of the defense: 23/02/2021
University: Universitat de València
Title: Efecto de la ingesta de glutamato monosódico en la fisiopatología de la enfermedad de alzheimer
Doctoral candidate: Yuste Pérez, Raquel
Director(s): Fuchsberger, Tanja; Viña Ribes, José; Lloret Alcañiz, Ana
Date of the defense: 22/07/2020
University: Universitat de València
Title: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctoral candidate: Muñoz Cebriá, José Enrique
Director(s): Viña, José; Borrás, Consuelo; Gambini, Juan
Date of the defense: 01/07/2020
University: Universitat de València
Title: Impacto del ejercicio físico a largo plazo en la neuroprotección de sujetos de mediana edad: estudio de los mecanismos moleculares involucrados
Doctoral candidate: De La Rosa González, Adrián
Director(s): Gómez Cabrera, M. Carmen; Sanfeliú Pujol, Coral; Viña Ribes, José
Date of the defense: 05/06/2020
University: Universitat de València
Title: Regulation of antioxidant defenses in the prevention of skeletal muscle deconditioning
Doctoral candidate: Arc-Chagnaud, Coralie
Director(s): Viña Ribes, José; Gómez-Cabrera, Carmen; Chopard, Angèle; Brioche, Thomas
Date of the defense: 22/11/2019
University: Universitat de València
Title: Effect of two distinct implant macro-designs on the osseointegration of bicatortically installed implants in two topographic sites. A histomorphometric study in rabbit tibiae
Doctoral candidate: Soto Peñaloza, David Reynaldo
Director(s): Peñarrocha Oltra, David; Viña Almunia, Jose; Martín De Llano, José Javier
Date of the defense: 15/11/2019
University: Universitat de València
Title: El sedentarismo en los adultos mayores del entorno rural: estrategias de entrenamiento concentrado versus distribuido
Doctoral candidate: Monteagudo Chiner, Pablo
Director(s): Blasco Lafarga, Cristina; Gómez Cabrera, M. Carmen; Pesce, Caterina
Date of the defense: 26/07/2019
University: Universitat de València
Title: Moderate overexpression of glucose-6-phosphate dehydrogenase improves healthspan in mice. Implications in skeletal muscle regeneration
Doctoral candidate: Salvador Pascual, Andrea
Director(s): Viña Ribes, José; Gomez Cabrera, M. Carmen
Date of the defense: 15/07/2019
University: Universitat de València
Title: Entrenamiento respiratorio: cambios en la presión inspiratoria máxima y relación con la funcionalidad del adulto mayor sano
Doctoral candidate: Roldán Aliaga, Ainoa
Director(s): Blasco Lafarga, Cristina; Blasco Lafarga, Nieves M; Gómez Cabrera, M. Carmen
Date of the defense: 20/05/2019
University: Universitat de València
Title: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctoral candidate: Mirón Mombiela, Rebeca
Director(s): Borrás Blasco, Consuelo; Forner Giner, Juana
Date of the defense: 28/01/2019
University: Universitat de València