Grupo de investigación en envejecimiento y ejercicio físico

Área de Metabolismo y Daño Orgánico

Medicina regenerativa en el envejecimiento

Identificación del entrenamiento físico como fármaco para el tratamiento de la fragilidad relacionada con la edad

Demostrar que G6PD protege contra el daño oxidativo y mejora la esperanza de vida en ratones

Reducir el estrés: un nuevo concepto en la enfermedad de Alzheimer

Dr. José Viña Ribes
Coordinador
Dr. José Viña Ribes
jose.vina@uv.es

INVESTIGADORES
R4 Senior

José Viña Ribes    

R3 Consolidado

Eva Serna García
Ana Lloret Alcañiz

R2 Novel / Emergente

José Viña Almunia

R1 Predoctoral

Rut Campos Jiménez
Alicia Valls Arrufat

STAFF
Colaborador/a
Enfermero/a
Técnico/a
Apoyo

Cristina Amézcua García

Publicaciones
Author Correction: Brain areas lipidomics in female transgenic mouse model of Alzheimer’s disease. Ferré-González L, Balaguer Á, Roca M, Ftara A, Lloret A, Cháfer-Pericás C. Scientific Reports. 2024 Jan 24;14(1):2100. doi: 10.1038/s41598-024-52528-z. PMID: 38267503

Glucose 6-P dehydrogenase overexpression improves aging-induced endothelial dysfunction in aorta from mice: role of arginase II. Serna E, Mauricio MD, San Miguel T, Guerra Ojeda S, Verdu D, Valls A, Arc-Chagnaud C, De la Rosa A, Vina J. International Journal of Molecular Sciences. 2023 Feb 11;24(4):3622. doi: 10.3390/ijms24043622. PMID: 36835034

Influence of abutment shape on peri-implant tissue conditions: a randomized clinical trial. Bernabeu-Mira JC, Penarrocha-Diago M, Vina-Almunia J, Romero-Gavilan F, Perez-Sayans M, Penarrocha-Oltra D. Clinical Oral Implants Research. 2023 Oct;34(10):1015-1024. doi: 10.1111/clr.14130. PMID: 37461127

Influence of the use of autogenous bone particles to close the access window after maxillary sinus floor augmentation: a micro-computed tomography and positron emission tomography study in rabbits (Apr, 10.1007/s10006-022-01063-0, 2022). Feletto L, Botticelli D, Alccayhuaman K, Penarrocha-Diago M, Ezzeddin-Ayoub M, Zaragozi-Alonso R, Vina-Almunia J. Oral and Maxillofacial Surgery-Heidelberg. 2023 Sep;27(3):543. doi: 10.1007/s10006-022-01077-8. PMID: 35650459

Influence of the use of autogenous bone particles to close the access window after maxillary sinus floor augmentation: a micro-computed tomography and positron emission tomography study in rabbits. Feletto L, Botticelli D, Apaza-Alcayhuaman K, Penarrocha-Diago M, Ezzeddin-Ayoub M, Zaragozi-Alonso R, Vina-Almunia J. Oral and Maxillofacial Surgery-Heidelberg. 2023 Jun;27(2):289-295. doi: 10.1007/s10006-022-01063-0. PMID: 35482147

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models. Costa-Machado L, Garcia-Dominguez E, McIntyre R, Lopez-Aceituno J, Ballesteros-Gonzalez A, Tapia-Gonzalez A, Fabregat-Safont D, Eisenberg T, Gomez J, Plaza A, Sierra-Ramirez A, Perez M, Villanueva-Bermejo D, Fornari T, Loza M, Herradon G, Hofer S, Magnes C, Madeo F, Duerr J, Pozo O, Galindo M, Del Pino I, Houtkooper R, Megias D, Vina J, Gomez-Cabrera M, Fernandez-Marcos P. Nature Communications. 2023 May 15;14(1):2779. doi: 10.1038/s41467-023-38410-y. PMID: 37188705

Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice. Rodriguez-Ramiro I, Pastor-Fernández A, López-Aceituno JL, Garcia-Dominguez E, Sierra-Ramirez A, Valverde AM, Martinez-Pastor B, Efeyan A, Gomez-Cabrera MC, Viña J, Fernandez-Marcos PJ. Free Radical Biology & Medicine. 2023 Nov 29:210:448-461. doi: 10.1016/j.freeradbiomed.2023.11.019. PMID: 38036067

Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome. Sol J, Obis E, Mota Martorell N, Pradas I, Galo Licona J, Martin Gari M, Fernandez Bernal A, Ortega Bravo M, Mayneris Perxachs J, Borras C, Vina J, de la Fuente M, Mate I, Biarnes C, Pedraza S, Vilanova J, Brugada R, Ramos R, Serena J, Ramio-Torrenta L, Pineda V, Daunis I Estadella P, Thio Henestrosa S, Barretina J, Garre Olmo J, Portero Otin M, Fernandez Real J, Puig J, Jove M, Pamplona R. Aging Cell. 2023 Jun;22(6):e13821. doi: 10.1111/acel.13821. PMID: 36951231

Pomegranate extract administration reverses loss of motor coordination and prevents oxidative stress in cerebellum of aging mice. Verdú D, Valls A, Díaz A, Carretero A, Dromant M, Kuligowski J, Serna E, Viña J. Antioxidants. 2023 Nov 11;12(11):1991. doi: 10.3390/antiox12111991. PMID: 38001844

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein-energy malnutrition in predementia aged people: study protocol for Choko-Age. Pedrinolla A, Isanejad M, Antognelli C, Bartolini D, Borras C, Cavedon V, Di Sante G, Migni A, Mas-Bargues C, Milanese C, Baschirotto C, Modena R, Pistilli A, Rende M, Schena F, Stabile AM, Telesa NV, Tortorella S, Hemmings K, Vina J, Wang E, McArdle A, Jackson MJ, Venturelli M, Galli F. BMJ Open. 2023 Dec 22;13(12):e072291. doi: 10.1136/bmjopen-2023-072291. PMID: 38135320

Systematic review of brain and blood lipidomics in Alzheimer’s disease mouse models. Ferre Gonzalez L, Lloret A, Chafer Pericas C. Progress in Lipid Research. 2023 Mar 5;90:101223. doi: 10.1016/j.plipres.2023.101223. PMID: 36871907

The role of aryl hydrocarbon receptor in the endothelium: a systematic review. Guerra-Ojeda S, Suarez A, Valls A, Verdu D, Pereda J, Ortiz-Zapater E, Carretero J, Mauricio M, Serna E. International Journal of Molecular Sciences. 2023 Aug 31;24(17):13537. doi: 10.3390/ijms241713537. PMID: 37686342

Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer’s Disease. Esteve D, Molina-Navarro MM, Giraldo E, Martínez-Varea N, Blanco-Gandia MC, Rodríguez-Arias M, García-Verdugo JM, Viña J, Lloret A. Molecular neurobiology. 2022 Feb;59(2):1168-1182. doi: 10.1007/s12035-021-02620-6. PMID: 34894324

Analysis of exosomal cargo provides accurate clinical, histologic and mutational information in non-small cell lung cancer. Durendez-Saez E, Calabuig-Farinas S, Torres-Martinez S, Moreno-Manuel A, Herreros-Pomares A, Escorihuela E, Mosqueda M, Gallach S, Guijarro R, Serna E, Suarez-Cabrera C, Paramio J, Blasco A, Camps C, Jantus-Lewintre E. Cancers. 2022 Jun 30;14(13):3216. doi: 10.3390/cancers14133216. PMID: 35804987

Blood DNA methylation patterns in older adults with evolving dementia. Fernandez Perez R, Alba Linares JJ, Tejedor JR, Fernandez Fernandez A, Calero M, Roman Dominguez A, Borras C, Vina J, Avila J, Medina M, Fernandez Fraga M. The journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Sep 1;77(9):1743-1749. doi: 10.1093/gerona/glac068. PMID: 35299244

Effects of GH on the aging process in several organs: mechanisms of actio. Tresguerres J, Fernandez-Tresguerres I, Vina J, Rancan L, Paredes S, Linillos-Pradillo B, Vara E. International Journal of Molecular Sciences. 2022 Jul 16;23(14):7848. doi: 10.3390/ijms23147848. PMID: 35887196

Exercise training as a modulator of epigenetic events in prostate tumors. Dufresne S, Gueritat J, Wong CP, Isanejad A, Ho E, Serna E, Gomez-Cabrera MC, Rebillard A. Prostate Cancer and Prostatic Diseases. 2022 Mar;25(1):119-122. doi: 10.1038/s41391-021-00380-x. PMID: 34007020

Functional transcriptomic analysis of centenarians’ offspring reveals a specific genetic footprint that may explain that they are less frail than age-matched non-centenarians’ offspring. Ingles M, Belenguer-Varea A, Serna E, Mas-Bargues C, Tarazona-Santabalbina F, Borras C, Vina J. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Oct 6;77(10):1931-1938. doi: 10.1093/gerona/glac119. PMID: 35640160

Genistein effect on cognition in prodromal Alzheimer’s disease patients. The GENIAL clinical trial. Vina J, Escudero J, Baquero M, Cebrian M, Carbonell-Asins J, Munoz J, Satorres E, Melendez J, Ferrer-Rebolleda J, Cozar-Santiago M, Santabarbara-Gomez J, Jove M, Pamplona R, Tarazona-Santabalbina F, Borras C. Alzheimers Research & Therapy. 2022 Nov 4;14(1):164. doi: 10.1186/s13195-022-01097-2. PMID: 36329553

Genistein, a tool for geroscience. Bargues C, Borras C, Vina J. Mechanisms of Ageing and Development. 2022 Jun;204:111665. doi: 10.1016/j.mad.2022.111665. PMID: 35307412

Glucosamine supplementation improves physical performance in trained mice. De la Rosa A, Olaso-Gonzalez G, Garcia-Dominguez E, Mastaloudis A, Hester S, Wood S, Gomez-Cabrera M, Vina J. Medicine and Science in Sports and Exercise. 2022 Mar 1;54(3):466-474. doi: 10.1249/MSS.0000000000002821. PMID: 34711707

Glucose 6-P dehydrogenase-an antioxidant enzyme with regulatory functions in skeletal muscle during exercise. Garcia-Dominguez E, Carretero A, Vina-Almunia A, Domenech-Fernandez J, Olaso-Gonzalez G, Vina J, Gomez-Cabrera MC. Cells. 2022 Sep 28;11(19):3041. doi: 10.3390/cells11193041. PMID: 36231003

Impact of supplementation with vitamins B6, B12, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: a systematic review. Olaso-Gonzalez G, Inzitari M, Bellelli G, Morandi A, Barcons N, Vina J. IUBMB Life. 2022 Jan;74(1):74-84. doi: 10.1002/iub.2507. PMID: 34058062

Long-lived humans have a unique plasma sphingolipidome. Pradas I, Jove M, Huynh K, Ingles M, Borras C, Mota-Martorell N, Galo-Licona JD, Puig J, Vina J, Meikle PJ, Pamplona R. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Apr 1;77(4):728-735. doi: 10.1093/gerona/glab360. PMID: 34871393

Multimodal strategy to rescue the brain in mild cognitive impairment: ketogenic oral nutrition supplementation with B vitamins and aerobic exercise. Cunnane SC, Swerdlow RH, Inzitari M, Olaso-Gonzalez G, Vina J. European Journal of Clinical Investigation. 2022 Sep;52(9):e13806. doi: 10.1111/eci.13806. PMID: 35488743

Real-life outcomes of a multicomponent exercise intervention in community-dwelling frail older adults and its association with nutritional-related factors. Millan-Domingo F, Tarazona-Santabalbina F, Carretero A, Olaso-Gonzalez G, Vina J, Gomez-Cabrera M. Nutrients. 2022 Dec 3;14(23):5147. doi: 10.3390/nu14235147. PMID: 36501177

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice. Sanz-Ros J, Romero-Garcia N, Mas-Bargues C, Monleon D, Gordevicius J, Brooke RT, Dromant M, Diaz A, Derevyanko A, Guio-Carrion A, Roman-Dominguez A, Ingles M, Blasco MA, Horvath S, Vina J, Borras C. Science Advances. 2022 Oct 21;8(42):eabq2226. doi: 10.1126/sciadv.abq2226. PMID: 36260670

The multimodal action of genistein in Alzheimer’s and other age-related diseases. Mas-Bargues C, Borras C, Vina J. Free Radical Biology & Medicine. 2022 Apr;183:127-137. doi: 10.1016/j.freeradbiomed.2022.03.021. PMID: 35346775

The radiographic assessment of lung edema score of lung edema severity correlates with inflammatory parameters in patients with coronavirus disease 2019-Potential new admission biomarkers to predict coronavirus disease 2019 worsening. Marques P, Fernandez-Presa L, Carretero A, Gómez-Cabrera MC, Viña J, Signes-Costa J, Sanz MJ. Frontiers in Medicine. 2022 Aug 11;9:871714. doi: 10.3389/fmed.2022.871714. PMID: 36035415

Transcriptomic profile of epileptic children treated with ketogenic therapies. Ruiz-Herrero J, Olaso-Gonzalez G, Serna E, Canedo-Villarroya E, Correas A, Gambini J, Gomez-Cabrera M, Pedron-Giner C, Vina J. Journal of Integrative Neuroscience. 2022 Jan 28;21(1):31. doi: 10.31083/j.jin2101031. PMID: 35164467

A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts. Gomez-Cabrero D, Walter S, Abugessaisa I, Minambres-Herraiz R, Palomares L, Butcher L, Erusalimsky J, Garcia-Garcia F, Carnicero J, Hardman T, Mischak H, Zurbig P, Hackl M, Grillari J, Fiorillo E, Cucca F, Cesari M, Carrie I, Colpo M, Bandinelli S, Feart C, Peres K, Dartigues J, Helmer C, Vina J, Olaso G, Garcia-Palmero I, Martinez J, Jansen-Durr P, Grune T, Weber D, Lippi G, Bonaguri C, Sinclair A, Tegner J, Rodriguez-Manas L. GeroScience. 2021 Jun;43(3):1317-1329. doi: 10.1007/s11357-021-00334-0. PMID: 33599920

Adolescent binge-ethanol accelerates cognitive impairment and beta-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. Carlos Ledesma J, Rodriguez-Arias M, Gavito A, Sanchez-Perez A, Viña Ribes J, Medina Vera D, Rodriguez De Fonseca F, Minarro J. Addiction Biology. 2021 Jan;26(1):e12883. doi: 10.1111/adb.12883. PMID: 32043730

Aerobic exercise during advance stage of uncontrolled arterial hypertension. Pagan LU, Gomes MJ, Damatto RL, Lima Aline RR, Cezar MDM, Damatto FC, Reyes DRA, Campos DHS, Caldonazo TMM, Polegato BF, Fernandes DC, Laurindo FR, Fernandes AAH, Lloret A, Cicogna AC, Okoshi MP, Okoshi K. Frontiers in Physiology. 2021 Jun 3;12:675778. doi: 10.3389/fphys.2021.675778. PMID: 34149455

Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395

Diagnostic performance of muscle echo intensity and fractal dimension for the detection of frailty phenotype. Miron Mombiela R, Vucetic J, Monllor P, Cardenas-Herran JS, Taltavull de la Paz P, Borras C. Ultrasonic Imaging. 2021 Nov;43(6):337-352. doi: 10.1177/01617346211029656. PMID: 34238072

Electroencephalography as a non-invasive biomarker of alzheimer’s disease: a forgotten candidate to substitute CSF molecules?. Monllor P, Cervera-Ferri A, Lloret MA, Esteve D, Lopez B, Leon JL, Lloret A. International Journal of Molecular Sciences. 2021 Oct 8;22(19):10889. doi: 10.3390/ijms221910889. PMID: 34639229

Estrogen replacement therapy induces antioxidant and longevity-related genes in women after medically induced menopause. Borras C, Ferrando M, Ingles M, Gambini J, Lopez-Grueso R, Edo R, Mas-Bargues C, Pellicer A, Vina J. Oxidative Medicine and Cellular Longevity. 2021 Sep 9;2021:8101615. doi: 10.1155/2021/8101615. PMID: 34539974

Facial alveolar bone thickness and modifying factors of anterior maxillary teeth: a systematic review and meta-analysis of cone-beam computed tomography studies. Rojo-Sanchis J, Soto-Penaloza D, Penarrocha-Oltra D, Penarrocha-Diago M, Vina-Almunia J. BMC Oral Health. 2021 Mar 22;21(1):143. doi: 10.1186/s12903-021-01495-2. PMID: 33752651

Frailty assessment in a stable COPD cohort: is there a COPD-frail phenotype?. Naval E, Cruz Gonzalez M, Giraldos S, Calatayud J, Jornet M, Lluch I, Meseguer M, Ruiz Cubillan JJ, Vina J, Tarazona-Santabalbina FJ. COPD-Journal of Chronic Obstructive Pulmonary Disease. 2021 Oct;18(5):525-532. doi: 10.1080/15412555.2021.1975670. PMID: 34503389

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage. Arc-Chagnaud C, Salvador-Pascual A, Garcia-Dominguez E, Olaso-Gonzalez G, Correas A, Serna E, Brioche T, Chopard A, Fernandez-Marcos P, Serrano M, Serrano A, Munoz-Canoves P, Sebastia V, Vina J, Carmen Gomez-Cabrera M. Journal of Cachexia Sarcopenia and Muscle. 2021 Dec;12(6):1879-1896. doi: 10.1002/jcsm.12792. PMID: 34704386

Healthcare for older adults, where are we moving towards?. Tarazona-Santabalbina F, Gonzalez S, Navarro J, Vina J. International Journal of Environmental Research and Public Health. 2021 Jun 8;18(12):6219. doi: 10.3390/ijerph18126219. PMID: 34201289

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers. Garcia-Gimenez J, Mena-Molla S, Tarazona-Santabalbina F, Vina J, Gomez-Cabrera M, Pallardo F. International Journal of Environmental Research and Public Health. 2021 Feb 15;18(4):1883. doi: 10.3390/ijerph18041883. PMID: 33672064

Integrating pheromonal and spatial information in the amygdalo-hippocampal network. Villafranca-Faus M, Esteban Vila-Martin M, Esteve D, Merino E, Teruel-Sanchis A, Cervera-Ferri A, Martinez-Ricos J, Lloret A, Lanuza E, Teruel-Marti V. Nature Communications. 2021 Sep 6;12(1):5286. doi: 10.1038/s41467-021-25442-5. PMID: 34489431

Is oxidative stress the link between cerebral small vessel disease, sleep disruption, and oligodendrocyte dysfunction in the onset of Alzheimer’s disease?. Lloret A, Esteve D, Lloret MA, Monllor P, Lopez B, Leon JL, Cervera-Ferri A. Frontiers in Physiology. 2021 Aug 25;12:708061. doi: 10.3389/fphys.2021.708061. PMID: 34512381

Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Borras C, Abdelaziz KM, Diaz A, Gambini J, Jove M, Lopez-Grueso R, Mas-Bargues C, Monleon D, Pamplona R, Vina J. Mechanisms of Ageing and Development. 2021 Dec;200:111596. doi: 10.1016/j.mad.2021.111596. PMID: 34774606

Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Mas-Bargues C, Escrivá C, Dromant M, Borrás C, Viña J. Archives of Biochemistry and Biophysics. 2021 Sep 30;709:108941. doi: 10.1016/j.abb.2021.108941. PMID: 34097903

Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Gambini J, Gimeno-Mallench L, Olaso-Gonzalez G, Mastaloudis A, Traber M, Monleon D, Borras C, Vina J. Antioxidants. 2021 Feb 16;10(2):301. doi: 10.3390/antiox10020301. PMID: 33669360

Multicomponent training prevents memory deficit related to amyloid-beta protein-induced neurotoxicity. Soares CB, Dare LR, Lima KR, Lopes LF, Santos A, Garcia Dos A, Schimidt HL, Carpes FP, Lloret A, Vina J, Mello-Carpes P. Journal of Alzheimer’s Disease. 2021;83(1):143-154. doi: 10.3233/JAD-210424. PMID: 34275902

Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life. De la Rosa A, Gomez-Cabrera M, Vinue A, Gonzalez-Navarro H, Sanchez-Andres J, Vina J. Free radical biology & medicine. 2021 Feb 20;164:149-153. doi: 10.1016/j.freeradbiomed.2020.12.439. PMID: 33418115

Redox-related biomarkers in physical exercise. Gomez-Cabrera C, Carretero A, Millan-Domingo F, Garcia-Dominguez E, Correas AG, Olaso-Gonzalez G, Vina J. Redox Biology. 2021 Jun;42:101956. doi: 10.1016/j.redox.2021.101956. PMID: 33811000

Serum Levels of Clusterin, PKR, and RAGE Correlate with Amyloid Burden in Alzheimer’s Disease. Monllor P, Giraldo E, Badia M, de la Asuncion J, Alonso M, Lloret A, Vina J. Journal of Alzheimer’s disease. 2021;80(3):1067-1077. doi: 10.3233/JAD-201443. PMID: 33646167

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates. Duro-Castano A, Borras C, Herranz-Perez V, Blanco-Gandia M, Conejos-Sanchez I, Arminan A, Mas-Bargues C, Ingles M, Minarro J, Rodriguez-Arias M, Garcia-Verdugo J, Vina J, Vicent M. Science Advances. 2021 Mar 26;7(13):eabf9180. doi: 10.1126/sciadv.abf9180. PMID: 33771874

The oscillatory profile induced by the anxiogenic drug FG-7142 in the amygdala-hippocampal network is reversed by infralimbic deep brain stimulation: relevance for mood disorders. Vila-Merkle H, Gonzalez-Martinez A, Campos-Jimenez R, Martinez-Ricos J, Teruel-Marti V, Blasco-Serra A, Lloret A, Celada P, Cervera-Ferri A. Biomedicines. 2021 Jul 6;9(7):783. doi: 10.3390/biomedicines9070783. PMID: 34356846

Proyectos
Referencia: CHOKO-AGE AC20/00026
Título: Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK of protein energy malnutrition in pre-dementia AGEd people. ERA-HDHL Call for Joint Transnational Research Proposals on Development of targeted nutrition for prevention of undernutrition for older adults (PREVNUT)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: José Viña Ribes
Duración: 2021 – 2023
Presupuesto: 169.098 €
Referencia: PROMETEO/2019/097
Título: Diferencias de fragilidad entre generos: Evaluación de biomarcadores y estrategias de intervención
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: José Viña Ribes
Duración: 2020 – 2023
Presupuesto: 189.391 €
Referencia: PID2019-110906RB-100
Título: Nuevas intervenciones terapéuticas multidominio para retrasar la fragilidad y la discapacidad. Identificación de mecanismos moleculares con relevancia traslacional (Mitofrail)
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: José Viña Ribes, Mª Carmen Gómez Cabrera
Duración: 2020 – 2023
Presupuesto: 270.000 €
Referencia: 825546-DIABFRAIL-LATAM-
Título: Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmerica
Entidad Financiadora: European Commission
Investigador principal: José Viña Ribes
Duración: 2019 – 2024
Presupuesto: 273.720 €
Referencia: POCTEP 0348_CIE_6_E
Título: Estudio de la fragilidad cognitiva y su transición a la demencia mediante un conjunto de biomarcadores en sangre periférica. Intervención con genisteína
Entidad Financiadora: Fundación General del Consejo Superior de Investigaciones Científicas (FGCSIC)
Investigador principal: José Viña Ribes
Duración: 2018 – 2019
Presupuesto: 39.940 €
Referencia: CB16/10/00435
Título: CIBER de Fragilidad y Envejecimiento (CIBERFES)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: José Viña Ribes
Duración: 2017 –
Presupuesto:
Referencia: ADVANTAGE
Título: Managing Frailty. A comprehensive approach to promote a disability-free advanced age in Europe: the ADVANTAGE initiative
Entidad Financiadora: European Commission (3rd Health Program)
Investigador principal: Josep Redón i Mas, José Viña Ribes
Duración: 2016 – 2019
Presupuesto: 130.005 €
Referencia: PIE15/00013
Título: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Vicente Bodí Peris
Duración: 2016 – 2019
Presupuesto: 589.050 €
Referencia: SAF2016-75508-R
Título: Envejecimiento cerebral: protección contra el daño asociado al mismo y su aplicación a la enfermedad de Alzheimer
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: José Viña Ribes
Duración: 2016 – 2019
Presupuesto: 169.400 €
+ Información
Screening for and Managing the Person with Frailty in Primary Care: ICFSR Consensus Guidelines. Ruiz J, Dent E, Morley J, Merchant R, Beilby J, Beard J, Tripathy C, Sorin M, Andrieu S, Aprahamian I, Arai H, Aubertin-Leheudre M, Bauer J, Cesari M, Chen L, Cruz-Jentoft A, De Souto Barreto P, Dong B, Ferrucci L, Fielding R, Flicker L, Lundy J, Reginster J, Rodriguez-Manas L, Rolland Y, Sanford A, Sinclair A, Viña Ribes J, Waters D, Won C, Woo J, Vellas B. Journal of Nutrition Health & Aging. 2020;24(9):920-927. doi: 10.1007/s12603-020-1492-3. PMID: 33155616

Título: Study of the role of BCL-XL in healthy aging and frailty prevention
Doctorando: Román Domínguez, Aurora
Director: Borrás Blasco, Consuelo; Mas Bargues, Cristina; Viña Ribes, José
Fecha: 03/03/2023
Universidad: Universitat de València

Título: Modulación del balance redox como estrategia para un envejecimiento saludable
Doctorando: García Domínguez, Esther
Director: Viña Ribes, José; Gómez Cabrera, Mari Carmen; Blasco Lafarga, Cristina
Fecha: 01/01/2023
Universidad: Universidad de Valencia

Título: Efecto favorable de la comunicación intercelular a través de vesículas extracelulares derivadas de células madre del tejido adiposo en el envejecimiento.
Doctorando: Sanz Ros, Jorge Manuel
Director: Borrás Blasco, Consuelo; Viña Ribes, Jose; Mas Bargues, Cristina
Fecha: 16/09/2022
Universidad: Univeridad de Valencia

Título: Intervención con ejercicio físico multicomponente sobre el adulto mayor frágil en la vida real (Real Life Intervention)
Doctorando: Millán Domingo, Fernando
Director: Viña Ribes, José; Gómez Cabrera, María Carmen; Tarazona Santabalbina, Francisco José
Fecha: 01/07/2022
Universidad: Universitat de València

Título: Papel de la xantina oxidasa en la pérdida de masa muscular por inmovilización en humanos. Importancia del protocolo de obtención de biopsias musculares en los estudios de atrofia muscular
Doctorando: Sebastiá Alcàcer, Vicente
Director: Gómez Cabrera, Mª Carmen; Viña Ribes, José; Viosca Herrero, Enrique
Fecha: 28/06/2022
Universidad: Universitat de València

Título: Análisis de la anchura de la cortical vestibular en dientes anteriores maxilares y en la planificación virtual de implantes mediante tomografías computarizadas de hazcónico
Doctorando: Rojo Sanchis, Julio
Director: Peñarrocha Oltra, David; Viña Almunia, Jose
Fecha: 30/04/2021
Universidad: Universitat de València

Título: Influencia del procesamiento de la leche humana donada sobre la microbiota intestinal, la expresión genómica y el equilibrio oxidativo en recién nacidos pretérmino menores de 32 semanas de edad gestacional
Doctorando: Parra Llorca, Anna
Director: Vento, Máximo; Collado Amores, María Carmen; Serna García, Eva
Fecha: 23/02/2021
Universidad: Universitat de València

Título: Efecto de la ingesta de glutamato monosódico en la fisiopatología de la enfermedad de alzheimer
Doctorando: Yuste Pérez, Raquel
Director: Fuchsberger, Tanja; Viña Ribes, José; Lloret Alcañiz, Ana
Fecha: 22/07/2020
Universidad: Universitat de València

Título: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctorando: Muñoz Cebriá, José Enrique
Director: Viña, José; Borrás, Consuelo; Gambini, Juan
Fecha: 01/07/2020
Universidad: Universitat de València

Título: Impacto del ejercicio físico a largo plazo en la neuroprotección de sujetos de mediana edad: estudio de los mecanismos moleculares involucrados
Doctorando: De La Rosa González, Adrián
Director: Gómez Cabrera, M. Carmen; Sanfeliú Pujol, Coral; Viña Ribes, José
Fecha: 05/06/2020
Universidad: Universitat de València

Título: Regulation of antioxidant defenses in the prevention of skeletal muscle deconditioning
Doctorando: Arc-Chagnaud, Coralie
Director: Viña Ribes, José; Gómez-Cabrera, Carmen; Chopard, Angèle; Brioche, Thomas
Fecha: 22/11/2019
Universidad: Universitat de València

Título: Effect of two distinct implant macro-designs on the osseointegration of bicatortically installed implants in two topographic sites. A histomorphometric study in rabbit tibiae
Doctorando: Soto Peñaloza, David Reynaldo
Director: Peñarrocha Oltra, David; Viña Almunia, Jose; Martín De Llano, José Javier
Fecha: 15/11/2019
Universidad: Universitat de València

Título: El sedentarismo en los adultos mayores del entorno rural: estrategias de entrenamiento concentrado versus distribuido
Doctorando: Monteagudo Chiner, Pablo
Director: Blasco Lafarga, Cristina; Gómez Cabrera, M. Carmen; Pesce, Caterina
Fecha: 26/07/2019
Universidad: Universitat de València

Título: Moderate overexpression of glucose-6-phosphate dehydrogenase improves healthspan in mice. Implications in skeletal muscle regeneration
Doctorando: Salvador Pascual, Andrea
Director: Viña Ribes, José; Gomez Cabrera, M. Carmen
Fecha: 15/07/2019
Universidad: Universitat de València

Título: Entrenamiento respiratorio: cambios en la presión inspiratoria máxima y relación con la funcionalidad del adulto mayor sano
Doctorando: Roldán Aliaga, Ainoa
Director: Blasco Lafarga, Cristina; Blasco Lafarga, Nieves M; Gómez Cabrera, M. Carmen
Fecha: 20/05/2019
Universidad: Universitat de València

Título: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctorando: Mirón Mombiela, Rebeca
Director: Borrás Blasco, Consuelo; Forner Giner, Juana
Fecha: 28/01/2019
Universidad: Universitat de València