Research Group on Heart Failure

Cardiovascular Area

Phenotypic characterization of heart failure syndrome

Deepen into pathophysiological mechanisms in the different phenotypes of the disease

Development of tools to improve the diagnostic process of heart failure

Risk stratification in patients with acute and chronic heart failure

Evaluation of different therapeutic and monitoring strategies that allow improving the prognosis of heart failure

Dr. Julio Núñez Villota
Coordinator
Dr. Julio Núñez Villota
yulnunez@gmail.com; juenuvi@uv.es; julio.nunez@uv.es

RESEARCHERS
Leading, R4
Established, R3

Julio Núñez Villota    

Recognised/Emerging, R2

Enrique Santas Olmeda
Patricia Palau Sampio
Gema Miñana Escrivá

First Stage, R1

Gonzalo Núñez Marín
Miguel Lorenzo Hernández

STAFF
Collaborating Researchers

Rafael de la Espriella Juan
Laura López Bueno

Nurse

Carolina Martínez Botella
Evelin Idaly Bejerano Sandoval
Francisco Javier Cebrián García

Technicians

Adoración Pérez Sánchez
Adriana Conesa Bona
Sandra Villar Conejos
Teresa Benito Ferrer

Administrative assistant
Publications
Consensus document on the management of hyperkalemia. Ortiz A, Galan C, Carlos Fernandez-Garcia J, Cerezo J, Ochoa R, Nunez J, Gutierrez F, Navarro-Gonzalez J. Nefrologia. 2024 Jan 1:S2013-2514(23)00178-5. doi: 10.1016/j.nefroe.2023.12.002. PMID: 38169239

Efficacy and safety of acoramidis in transthyretin amyloid cardiomyopathy. Gillmore JD, Judge DP, Cappelli F, Fontana M, Garcia-Pavia P, Gibbs S, Grogan M, Hanna M, Hoffman J, Masri A, Maurer MS, Nativi-Nicolau J, Obici L, Poulsen SH, Rockhold F, Shah KB, Soman P, Garg J, Chiswell K, Xu H, Cao X, Lystig T, Sinha U, Fox JC. New England Journal of Medicine. 2024 Jan 11;390(2):132-142. doi: 10.1056/NEJMoa2305434. PMID: 38197816

Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: a substudy of the TRAINING-HF trial. Palau P, Lopez L, Dominguez E, de la Espriella R, Campuzano R, Castro A, Minana G, Fernandez-Cisnal A, Sanchis J, Nunez J. Journal of Cachexia, Sarcopenia and Muscle. 2024 Jan 15. doi: 10.1002/jcsm.13419. PMID: 38225218

Preload reduction therapies in heart failure. Khan MS, Paracha AA, Biegus J, Espriella R, Núñez J, Santos-Gallego CG, Yaranov D, Fudim M. Heart Failure Clinics. 2024 Jan;20(1):71-81. doi: 10.1016/j.hfc.2023.05.004. PMID: 37953023

Prevalence and clinical profile of kidney disease in patients with chronic heart failure. Insights from the Spanish cardiorenal registry. Cobo Marcos M, de la Espriella R, Gayan Ordas J, Llacer P, Pomares A, Fort A, Ponz de Antonio I, Mendez A, Blazquez-Bermejo Z, Caravaca Perez P, Rubio Gracia J, Recio-Mayoral A, Zegri I, Garcia Pinilla J, Montero Hernandez E, Castro A, Soler M, Gorriz J, Bascompte Claret R, Fluvia-Brugues P, Manzano L, Nunez J. Revista Espanola de Cardiologia (English ed.). 2024 Jan;77(1):50-59. doi: 10.1016/j.rec.2023.05.003. PMID: 37217135

Protocolized natriuresis-guided decongestion improves diuretic response: the multicenter ENACT-HF study. Dauw J, Charaya K, Lelonek M, Zegri-Reiriz I, Nasr S, Paredes-Paucar CP, Borbély A, Erdal F, Benkouar R, Cobo-Marcos M, Barge-Caballero G, George V, Zara C, Ross NT, Barker D, Lekhakul A, Frea S, Ghazi AM, Knappe D, Doghmi N, Klincheva M, Fialho I, Bovolo V, Findeisen H, Alhaddad IA, Galluzzo A, De la Espriella R, Tabbalat R, Miró Ò, Singh JS, Nijst P, Dupont M, Martens P, Mullens W. Circulation-Heart Failure. 2024 Jan;17(1):e011105. doi: 10.1161/CIRCHEARTFAILURE.123.011105. PMID: 38179728

Reply to “Letter to the Editor – Consensus document on the management of hyperkalaemia”. Ortiz A, Del Arco Galan C, Fernandez-Garcia J, Gomez Cerezo J, Iban Ochoa R, Nunez J, Pita Gutierrez F, Navarro-Gonzalez J. Nefrologia. 2024 Jan 10:S2013-2514(24)00012-9. doi: 10.1016/j.nefroe.2023.09.006. PMID: 38212173

The blood urea nitrogen to creatinine ratio in chronic heart failure: ‘When the past is prologue’. De la Espriella R, Ortiz A, Nunez J. European Journal of Heart Failure. 2024 Jan 18. doi: 10.1002/ejhf.3146. PMID: 38239035

A model-driven transformation approach for the modelling of processes in clinical practice guidelines. Martinez-Salvador B, Marcos M, Palau P, Mafe E. Artificial Intelligence in Medicine. 2023 Mar;137:102495. doi: 10.1016/j.artmed.2023.102495. PMID: 36868689

Acute effects of in-hospital resistance training on clinical outcomes in patients undergoing total knee arthroplasty: a randomized controlled trial. Nunez-Cortes R, Lopez-Bueno L, Lopez-Bueno R, Cuenca-Martinez F, Suso-Marti L, Silvestre A, Casana J, Cruz-Montecinos C, Andersen L, Calatayud J. American Journal of Physical Medicine & Rehabilitation. 2023 Nov 22. doi: 10.1097/PHM.0000000000002366. PMID: 38063321

An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure. Nunez-Marin G, Iraola D, Lorenzo M, de la Espriella R, Villar S, Santas E, Minana G, Sanchis J, Carratala A, Miro O, Bayes-Genis A, Nunez J. Expert Review of Molecular Diagnostics. 2023 Jun;23(6):521-533. doi: 10.1080/14737159.2023.2216386. PMID: 37216616

Assessment of filling pressures and fluid overload in heart failure: an updated perspective. Espriella R, Cobo M, Santas E, Verbrugge F, Fudim M, Girerd N, Minana G, Luis Gorriz J, Bayes-Genis A, Nunez J. Revista Espanola de Cardiologia (English ed.). 2023 Jan;76(1):47-57. doi: 10.1016/j.rec.2022.07.009. PMID: 35934293

Baseline resting heart rate and responsiveness to a home-based inspiratory muscle training program in long COVID. Palau P, Nunez J, Dominguez E, Albiach C, Marin P, Lopez L. Revista Espanola de Cardiologia (English ed.). 2023 Oct 25:S1885-5857(23)00277-3. doi: 10.1016/j.rec.2023.10.001. PMID: 37884259

C-reactive protein in patients with acute heart failure and preserved ejection fraction. Villar S, Mollar A, Lorenzo M, Nunez G, de la Espriella R, Nunez J. Revista Espanola de Cardiologia (English ed.). 2023 Nov 22:S1885-5857(23)00309-2. doi: 10.1016/j.rec.2023.11.002. PMID: 38000626

CA125 for fluid overload monitoring a new life for an old tool. Bayes-Genis A, de la Espriella R, Núñez J. Journal of the American College of Cardiology. 2023 Jul 11;82(2):158-160. doi: 10.1016/j.jacc.2023.05.016. PMID: 37407114

Cardiac magnetic resonance outperforms echocardiography to predict subsequent implantable cardioverter defibrillator therapies in ST-segment elevation myocardial infarction patients. Marcos-Garces V, Perez N, Gavara J, Lopez-Lereu M, Monmeneu J, Rios-Navarro C, de Dios E, Merenciano-Gonzalez H, Gabaldon-Perez A, Ferrero-de-Loma-Osorio A, Martinez-Brotons A, Bondanza L, Sanchez-Gomez J, Albiach C, Nunez J, Bayes-Genis A, Chorro F, Ruiz-Granell R, Bodi V. Frontiers in Cardiovascular Medicine. 2023 Feb 3;10:991307. doi: 10.3389/fcvm.2023.991307. PMID: 36818338

Case report: Alternative approach for management of refractory volume overload in heart failure: usefulness of venous leg compression. Macián C, Pocull D, Dominguez F, López-Azor J, Garcia-Pavia P, Nuñez J, Marcos M. Frontiers in Cardiovascular Medicine. 2023 Sep 29:10:1230980. doi: 10.3389/fcvm.2023.1230980. PMID: 37840957

Chronotropic index and long-term outcomes in heart failure with preserved ejection fraction. Palau P, Dominguez E, Seller J, Sastre C, Sanchis J, Lopez L, Bodi V, Llacer P, Minana G, Espriella R, Bayes-Genis A, Nunez J. Revista Espanola de Cardiologia (English ed.). 2023 Jul;76(7):511-518. doi: 10.1016/j.rec.2022.08.003. PMID: 36038124

Clinical predictors and prognosis of Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) without ST-Segment elevation in older adults. Gabaldon Perez A, Bonanad C, Garcia Blas S, Marcos Garces V, Gonzalez D’Gregorio J, Fernandez Cisnal A, Valero E, Minana G, Merenciano Gonzalez H, Mollar A, Bodi V, Nunez J, Sanchis J. Journal of Clinical Medicine. 2023 Feb 2;12(3):1181. doi: 10.3390/jcm12031181. PMID: 36769828

Consensus document on palliative care in cardiorenal patients. Bonanad C, Buades J, Leiva J, de la Espriella R, Marcos M, Núñez J, García-Llana H, Facila L, Sánchez R, Rodríguez-Osorio L, Alonso-Babarro A, Quiroga B, Berroteran D, Rodríguez C, Maidana D, Díez J. Frontiers in Cardiovascular Medicine. 2023 Dec 19:10:1225823. doi: 10.3389/fcvm.2023.1225823. PMID: 38179502

Correction to: Diagnosis of heart failure with preserved ejection fraction: a systematic narrative review of the evidence. Formiga F, Nuñez J, Moraga MJC, Marcos MC, Egocheaga MI, García-Prieto CF, Trueba-Sáiz A, Gilarranz AM, Rodriguez JMF. Heart Failure Reviews. 2023 Nov 13. doi: 10.1007/s10741-023-10365-8. PMID: 37953396

Corrigendum to Hyperkalemia in acute heart failure: short term outcomes from the EAHFE registry [American Journal of Emergency Medicine, 70C (2023) 1-9]. Rafique Z, Fortuny MJ, Kuo D, Szarpak L, Llauger L, Espinosa B, Gil V, Jacob J, Alquézar-Arbé A, Andueza JA, Garrido JM, Aguirre A, Fuentes M, Alonso H, Lucas-Imbernón FJ, Bibiano C, Burillo-Putze G, Núñez J, Mullens W, Lopez-Ayala P, Mueller C, Llorens P, Peacock F, Miró Ò. American Journal of Emergency Medicine. 2023 Sep;71:251. doi: 10.1016/j.ajem.2023.05.022. PMID: 37268493

Current role of SLGT2 inhibitors in the management of the whole spectrum of heart failure: focus on dapagliflozin. Escobar C, Pascual-Figal D, Manzano L, Nuñez J, Camafort M. Journal of Clinical Medicine. 2023 Oct 27;12(21):6798. doi: 10.3390/jcm12216798. PMID: 37959263

Dapagliflozin and short-term changes on circulating antigen carbohydrate 125 in heart failure with reduced ejection fraction. Amiguet M, Palau P, Dominguez E, Seller J, Pinilla J, de la Espriella R, Minana G, Valle A, Sanchis J, Gorriz J, Bayes-Genis A, Nunez J. Scientific Reports. 2023 Jun 30;13(1):10591. doi: 10.1038/s41598-023-37491-5. PMID: 37391470

Derivation and external validation of machine-learning- models for risk stratification in chest pain with normal troponin. Fernandez-Cisnal A, Lopez-Ayala P, Valero E, Koechlin L, Catarrala A, Boeddinghaus J, Noceda J, Nestelberger T, Miro Andreu O, Nunez J, Mueller C, Sanchis J. European Heart Journal. Acute Cardiovascular Care. 2023 Nov 16;12(11):743-752. doi: 10.1093/ehjacc/zuad089. PMID: 37531633

Diagnosis of heart failure with preserved ejection fraction: a systematic narrative review of the evidence. Formiga F, Nuñez J, Moraga M, Marcos M, Egocheaga M, García-Prieto C, Trueba-Sáiz A, Gilarranz A, Rodriguez J. Heart Failure Reviews. 2023 Oct 20. doi: 10.1007/s10741-023-10360-z. PMID: 37861854

Early glomerular filtration rate decline is associated with hemoglobin rise following dapagliflozin initiation in heart failure with reduced ejection fraction. Minana G, de la Espriella R, Palau P, Amiguet M, Seller J, Garcia Pinilla J, Nunez E, Gorriz J, Valle A, Sanchis J, Genis A, Nunez J. Revista Espanola De Cardiologia (english Ed.). 2023 Oct;76(10):783-792. doi: 10.1016/j.rec.2023.03.007. PMID: 36958534

Early glomerular filtration rates changes and risk of mortality in acute heart failure. The modifying role of admission renal function and decongestion. Lorenzo M, Nunez G, Fuertes-Kenneally L, de la Espriella R, Villar S, Miro O, Llorens P, Santas E, Minana G, Bodi V, Sanchis J, Carratala A, Bayes-Genis A, Nunez J. European Journal of Internal Medicine. 2023 Sep;115:96-103. doi: 10.1016/j.ejim.2023.05.037. PMID: 37316355

Effect of paced heart rate on quality of life and natriuretic peptides for stage B or C HFpEF: a secondary analysis of the myPACE Trial. De la Espriella R, Wahlberg K, Infeld M, Palau P, Nunez E, Sanchis J, Meyer M, Nunez J. European Journal of Heart Failure. 2023 Dec 20. doi: 10.1002/ejhf.3107. PMID: 38124404

Effect of routine invasive vs conservative strategy in older adults with frailty and non-st-segment elevation acute myocardial infarction: a randomized clinical trial. Sanchis J, Bueno H, Minana G, Guerrero C, Marti D, Martinez-Selles M, Dominguez-Perez L, Diez-Villanueva P, Barrabes J, Marin F, Villa A, Sanmartin M, Llibre C, Sionis A, Carol A, Garcia-Blas S, Calvo E, Morales Gallardo M, Elizaga J, Gomez-Blazquez I, Alfonso F, Garcia Del Blanco B, Nunez J, Formiga F, Ariza-Sole A. JAMA Internal Medicine. 2023 May 1;183(5):407-415. doi: 10.1001/jamainternmed.2023.0047. PMID: 36877502

Empagliflozin cardiovascular and renal effectiveness and safety compared to dipeptidyl peptidase-4 inhibitors across 11 countries in Europe and Asia: results from the EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) study. Karasik A, Lanzinger S, Chia-Hui Tan E, Yabe D, Kim DJ, Sheu WHH, Melzer-Cohen C, Holl RW, Ha KH, Khunti K, Zaccardi F, Subramanian A, Nirantharakumar K, Nystrom T, Niskanen L, Linnemann Jensen M, Hoti F, Klement R, Deruaz-Luyet A, Kyaw MH, Koeneman L, Vistisen D, Carstensen B, Halvorsen S, Langslet G, Fazeli Farsani S, Patorno E, Nunez J. Diabetes & Metabolism. 2023 Jan 3;49(2):101418. doi: 10.1016/j.diabet.2022.101418. PMID: 36608816

Empagliflozin is associated with lower cardiovascular risk compared with dipeptidyl peptidase-4 inhibitors in adults with and without cardiovascular disease: EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) study results from Europe and Asia. Vistisen D, Carstensen B, Elisabetta P, Lanzinger S, Tan E, Yabe D, Kim D, Sheu W, Melzer-Cohen C, Holl R, Núñez J, Ha K, Halvorsen S, Langslet G, Karasik A, Nyström T, Niskanen L, Guleria S, Klement R, Carrasco M, Foersch J, Shay C, Koeneman L, Hoti F, Farsani S, Khunti K, Zaccardi F, Subramanian A, Nirantharakumar K. Cardiovascular Diabetology. 2023 Aug 31;22(1):233. doi: 10.1186/s12933-023-01963-9. PMID: 37653496

Evaluation of functional warm ischemia time during controlled donation after circulatory determination of death using normothermic regional perfusion (ECMO-TT): a prospective multicenter cohort study. Martinez-Castro S, Navarro R, Garcia-Perez M, Segura J, Carbonell J, Hornero F, Guijarro J, Zaplana M, Bruno M, Tur A, Martinez-Leon J, Zaragoza R, Nunez J, Dominguez-Gil B, Badenes R. Artificial Organs. 2023 Aug;47(8):1371-1385. doi: 10.1111/aor.14539. PMID: 37042612

Evolocumab has no effects on HFrEF injury biomarkers: the EVO-HF trial. Bayes-Genis A, Lupon J, Revuelta-Lopez E, Llibre C, Gastelurrutia P, Domingo M, Cediel G, Codina P, Santiago-Vacas E, Rangel-Sousa D, Fernandez-Cisnal A, Minana G, Mollar A, Nunez J. European Journal of Heart failure. 2023 Aug;25(8):1439-1443. doi: 10.1002/ejhf.2932. PMID: 37323111

Exercise-induced hypoalgesia with end-stage knee osteoarthritis during different blood flow restriction levels: sham-controlled crossover study. Ogrezeanu D, Lopez-Bueno L, Sanchis-Sanchez E, Suso-Marti L, Lopez-Bueno R, Nunez-Cortes R, Cruz-Montecinos C, Perez-Alenda S, Casana J, Gargallo P, Calatayud J. PM & R. 2023 Oct 5. doi: 10.1002/pmrj.13076. PMID: 37796567

Frailty and outcomes in heart failure patients from high-, middle-, and low-income countries. Leong D, Joseph P, Mcmurray J, Rouleau J, Maggioni A, Lanas F, Sharma S, Núñez J, Mohan B, Celik A, Abdullakutty J, Ogah O, Mielniczuk L, Balasubramanian K, Mccready T, Grinvalds A, Yusuf S. European Heart Journal. 2023 Nov 7;44(42):4435-4444. doi: 10.1093/eurheartj/ehad595. PMID: 37639487

Galectin-3, acute kidney injury and myocardial damage in patients with acute heart failure. Horiuchi Y, Wettersten N, VAN Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Duff S, Maisel A, Murray P. Journal of Cardiac Failure. 2022 Nov 1;S1071-9164(22)01171-X. doi: 10.1016/j.cardfail.2022.09.017. PMID: 36332898

Geographic differences in patients with acute myocardial infarction in the PARADISE-MI Trial. Butt J, Claggett B, Miao Z, Jering K, Sim D, van der Meer P, Ntsekhe M, Amir O, Cho M, Carrillo-Calvillo J, Nunez J, Cadena A, Kerkar P, Maggioni A, Steg P, Granger C, Mann D, Merkely B, Lewis E, Solomon S, Zhou Y, Kober L, Braunwald E, McMurray J, Pfeffer M. European Journal of Heart Failure. 2023 Aug;25(8):1228-1242. doi: 10.1002/ejhf.2851. PMID: 37042062

Hospital development of heart failure follow-up units and short-term prognosis after acute decompensation in Spain. Lopez Diez MP, Alquezar Arbe A, Jacob J, Llorens P, Llauger L, Herrero P, Gil V, Nunez J, Martin Sanchez FJ, Miro O. International Journal of Cardiology. 2023 May 1;378:64-70. doi: 10.1016/j.ijcard.2023.02.031. PMID: 36804513

Hyperkalemia in acute heart failure: short term outcomes from the EAHFE registry. Rafique Z, Fortuny M, Kuo D, Szarpak L, Llauger L, Espinosa B, Gil V, Jacob J, Alquezar-Arbe A, Andueza J, Garrido J, Aguirre A, Fuentes M, Alonso H, Lucas-Imbernon F, Bibiano C, Burillo-Putze G, Nunez J, Mullens W, Lopez-Ayala P, Mueller C, Llorens P, Peacock F, Miro O. The American Journal of Emergency Medicine. 2023 May 9;70:1-9. doi: 10.1016/j.ajem.2023.05.005. PMID: 37186977

Identifying the patient with heart failure to be treated with vericiguat. Escobar Cervantes C, Esteban Fernandez A, Recio Mayoral A, Mirabet S, Gonzalez Costello J, Rubio Gracia J, Nunez J, Gonzalez Franco A, Bonilla Palomas J. Current Medical Research and Opinion. 2023 May;39(5):661-669. doi: 10.1080/03007995.2023.2189857. PMID: 36897009

Impact of congestion and perfusion status in the emergency department on severity of decompensation and short-term prognosis in patients with acute heart failure. Espinosa B, Llorens P, Gil V, Jacob J, Alquezar-Arbe A, Masip J, Llauger L, Tost J, Andueza JA, Garrido JM, Soy-Ferrer E, Aguera-Urbano C, Herrero P, Gil-Rodrigo A, Millan J, Mecina AB, Torres-Garate R, Cabrera-Gonzalez N, Nunez J, Miro O. European Heart Journal. Acute Cardiovascular Care. 2023 Apr 3;12(3):165-174. doi: 10.1093/ehjacc/zuac115. PMID: 36137176

Impact of dapagliflozin on cardiac remodelling in patients with chronic heart failure: the DAPA-MODA study. Pascual-Figal D, Zamorano J, Domingo M, Morillas H, Nunez J, Marcos M, Riquelme-PeTrez A, Teis A, Santas E, Caro-Martinez C, Pinilla J, Rodriguez-Palomares J, Dobarro D, Restrepo-Cordoba M, Gonzalez-Juanatey J, Genis A. European Journal of Heart Failure. 2023 Aug;25(8):1352-1360. doi: 10.1002/ejhf.2884. PMID: 37211950

Impact of persistent microvascular obstruction late after STEMI on AdverseLV remodeling: a CMR Study. Bodi V, Gavara J, Lopez-Lereu M, Monmeneu J, de Dios E, Perez-Sole N, Bonanad C, Marcos-Garces V, Canoves J, Minana G, Nunez J, Moratal D, Chorro F, Rodriguez-Palomares J, Freixa A, Borras R, Ortiz-Perez J, Rios-Navarro C. JACC. Cardiovascular Imaging. 2023 Jul;16(7):919-930. doi: 10.1016/j.jcmg.2023.01.021. PMID: 37052556

Impact of worsening renal function detected at emergency department arrival on acute heart failure short-term outcomes. Llauger L, Espinosa B, Rafique Z, Boone S, Beuhler G, Millan Soria J, Gil V, Jacob J, Alquezar Arbe A, Campos Meneses M, Escoda R, Tost J, Martin Mojarro E, Aguirre A, Lopez Grima ML, Nunez J, Mullens W, Lopez Ayala P, Mueller C, Llorens P, Peacock F, Miro O. European Journal of Emergency Medicine. 2023 Apr 1;30(2):91-101. doi: 10.1097/MEJ.0000000000001016. PMID: 36787242

Implications of worsening renal function before hospitalization for acute heart failure. Wettersten N, Duff S, Horiuchi Y, van Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, Murray P, Ix J. ESC Heart Failure. 2023 Feb;10(1):532-541. doi: 10.1002/ehf2.14221. PMID: 36325747

Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial. Santas E, Del Canto I, Cardells I, Miñana G, Llácer P, Almenar L, Fácila L, Maceira A, Sanchis J, Núñez J. ESC Heart Failure. 2023 Dec 20. doi: 10.1002/ehf2.14630. PMID: 38115745

Intrarenal venous flow pattern changes do relate with renal function alterations in acute heartfailure. De la Espriella R, Nunez-Marin G, Cobo M, de Castro Campos D, Llacer P, Manzano L, Zegri I, Rodriguez-Perez A, Santas E, Lorenzo M, Minana G, Nunez E, Gorriz J, Bayes-Genis A, Fudim M, Mullens W, Nunez J. JACC. Heart Failure. 2023 Aug 22:S2213-1779(23)00411-0. doi: 10.1016/j.jchf.2023.07.015. PMID: 37676214

Is dapagliflozin a cardiac anti-aging drug?. Bayes-Genis A, Nunez J. JACC. Heart Failure. 2023 Mar;11(3):305-306. doi: 10.1016/j.jchf.2022.10.008. PMID: 36647928

Kidney function changes in acute heart failure: a practical approach to interpretation and management. Kenneally L, Lorenzo M, Romero-Gonzalez G, Cobo M, Nunez G, Gorriz J, Barrios A, Fudim M, de la Espriella R, Nunez J. Clinical Kidney Journal. 2023 Feb 20;16(10):1587-1599. doi: 10.1093/ckj/sfad031. PMID: 37779845

Lipoprotein(a) and long-term recurrent infarction after an acute myocardial infarction. Miñana G, Cordero A, Fácila L, Company M, Fernández-Cisnal A, Valero E, Carratalá A, Navarro J, Llergo J, Fernández-Olmo R, Castro A, Bodi V, Sanchis J, Núñez J. American Journal of Cardiology. 2023 Oct 18:211:9-16. doi: 10.1016/j.amjcard.2023.10.028. PMID: 37858663

Long-term recurrent events in ST-elevation myocardial infarction and multivessel disease. The impact of different revascularization strategies. Rumiz E, Vilar JV, Cubillos A, Valero E, Berenguer A, Facila L, Vidal V, Fernandez C, Llopis G, Paya R, Nunez J. Revista Portuguesa de Cardiologia. 2023 May;42(5):445-451. doi: 10.1016/j.repc.2023.01.021. PMID: 36706913

Maximal functional capacity in subjects with isolated left bundle branch block: a pilot study. Palau P, Mendez J, Santas E, Nunez J, Lopez L, Briatore A, Dominguez E. Clinical Cardiology. 2023 Apr;46(4):386-389. doi: 10.1002/clc.23977. PMID: 36756685

MRI investigation of the differential impact of left ventricular ejection fraction after myocardial infarction in elderly vs. nonelderly patients to predict readmission for heart failure. Marcos Garces V, Merenciano Gonzalez H, Gavara J, Gabaldon Perez A, Lopez Lereu MP, Monmeneu JV, Nunez J, Perez N, Rios Navarro C, de Dios E, Chorro FJ, Valente F, Lorenzatti D, Domenech Ximenos B, Alonso Tello A, Maymi Ballesteros M, Rello Sabate P, Morr CI, Ortiz Perez JT, Rodriguez Palomares JF, Bodi V. Journal of Magnetic Resonance Imaging. 2023 Nov;58(5):1507-1518. doi: 10.1002/jmri.28632. PMID: 36748793

Noncardiovascular morbidity and mortality across left ventricular ejection fraction catefories following hospitalization for heart failure. Santas E, Llacer P, Palau P, de la Espriella R, Minana G, Lorenzo M, Marin G, Miro O, Chorro F, Genis A, Sanchis J, Nunez J. Revista Espanola de Cardiologia (English ed.). 2023 Jun 12;S1885-5857(23)00158-5. doi: 10.1016/j.rec.2023.05.005. PMID: 37315921

Optimizing the management of patients with worsening heart failure: beyond heart failure hospitalization. Esteban Fernandez A, Recio Mayoral A, Gonzalez Franco A, Nunez Villota J, Mirabet S, Rubio Gracia J, Gonzalez Costello J, Bonilla Palomas J, Escobar Cervantes C. Expert Opinion on Pharmacotherapy. 2023 Apr;24(6):705-713. doi: 10.1080/14656566.2023.2195540. PMID: 36961877

Overlapping versus single long stents in long chronic total occlusions: insights of the Iberian CTO Registry. Jurado-Roman A, Minana G, Salinas P, Regueiro A, Caballero-Borrego J, Martin-Moreiras J, Rivero F, Lacunza J, Rondan J, Amat-Santos I, Sanchis J, Gonzalo N, Sabate M, Astorga J, Mohandes M, Gomez-Menchero A, Fernandez Diaz J, Ojeda S, Paredes E, Vaquerizo B, Vinhas H, Lopez M, Rodriguez S, Rumiz E, Jimenez-Mazuecos J, Lee D, Robles J, Gutierrez A, Morales F, Consuegra L, Maristany J, Bosa Ojeda F, Goicolea J, Escaned J, Galeote G. Minerva Cardiology and Angiology. 2023 Jun;71(3):284-293. doi: 10.23736/S2724-5683.22.06046-X. PMID: 35420282

Performance of an artificial intelligence chatbot with web search capability in cardiology-related assistance: a simulation study. Fernandez-Cisnal A, Lopez-Ayala P, Minana G, Boeddinghaus J, Mueller C, Sanchis J. Revista Espanola de Cardiologia (English ed.). 2023 Dec;76(12):1065-1067. doi: 10.1016/j.rec.2023.06.008. PMID: 37506970

Peritoneal and urinary sodium removal in refractory congestive heart failure patients included in an ambulatory peritoneal dialysis program: valuable for monitoring the course of the disease. Minana G, Gonzalez-Rico M, de la Espriella R, Gonzalez-Sanchez D, Montomoli M, Nunez E, Fernandez-Cisnal A, Villar S, Gorriz J, Nunez J. Cardiorenal Medicine. 2023 Aug 16;13(1):211-220. doi: 10.1159/000531631. PMID: 37586337

Potential role of empagliflozin in myocardial iron repletion following ferric carboxymaltose for heart failure. Lorenzo M, Espriella R, Cardells I, Luis Gorriz J, Bayes-Genis A, Nunez J. Revista Espanola de Cardiologia (english Ed.). 2023 Feb;76(2):121-123. doi: 10.1016/j.rec.2022.06.003. PMID: 35662676

Prognostic significance of plasma chloride in elderly patients hospitalized for acute heart failure. Llacer P, Croset F, Nunez J, Campos J, Fernandez C, Fabregate M, Del Hoyo B, Ruiz R, Lopez G, Tello S, Lorenzo A, Fernandez J, Manzano L. ESC Heart Failure. 2023 Aug;10(4):2637-2647. doi: 10.1002/ehf2.14434. PMID: 37349910

QT interval and short-term outcome in acute heart failure. Miro O, Aguilo O, Trullas J, Gil V, Espinosa B, Jacob J, Herrero-Puente P, Tost J, Lopez-Grima M, Comas P, Bibiano C, Llauger L, Martin Mojarro E, Lopez-Diez M, Nunez J, Rafique Z, Keene K, Peacock F, Lopez-Ayala P, Mueller C, Montero Perez-Barquero M, Mont L, Llorens P. Clinical Research in Cardiology. 2023 Dec;112(12):1754-1765. doi: 10.1007/s00392-023-02173-9. PMID: 37004527

Risk of death associated with incident heart failure in patients with known or suspected chronic coronary síndrome. Nunez J, Lorenzo M, Minana G, Palau P, Monmeneu JV, Lopez-Lereu MP, Gavara J, Marcos-Garces V, Rios-Navarro C, Perez N, de Dios E, Nunez E, Sanchis J, Chorro FJ, Bayes-Genis A, Bodi V. ESC Heart Failure. 2023 Feb;10(1):264-273. doi: 10.1002/ehf2.14179. PMID: 36196583

Safety and feasibility of transradial access for percutaneous coronary intervention in chronic total occlusions. Diego-Nieto A, Nunez J, Minana G, Amat-Santos I, Salinas-Sanguino P, Mohande M, Regueiro A, Pan M, Lacunza J, Caballero-Borrego J, Antonio Fernandez-Diaz J, Cisnal A, Santos-Martinez S, Gonzalo N, Vaquerizo B, Rivero F, Jurado-Roman A, Abellan-Huerta J, Gonzalez E, Rondan-Murillo J, Benito M, Burgo J, Mazuecos J, Ojeda F, Moreno-Ambroj C, Sabate M, Ojeda S, Aguilar R, Perez M, Sanchis J, Campo-Prieto A, Escaned J, Goicolea J, Martin-Moreiras J. Revista Espanola de Cardiologia (english Ed.). 2023 Apr;76(4):253-260. doi: 10.1016/j.rec.2022.05.019. PMID: 35691552

Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial. Borlaug B, Kitzman D, Davies M, Rasmussen S, Barros E, Butler J, Einfeldt M, Hovingh G, Moller D, Petrie M, Shah S, Verma S, Abhayaratna W, Ahmed F, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovsky V, Nunez J, Perna E, Schou M, Senni M, van der Meer P, Von Lewinski D, Wolf D, Kosiborod M. Nature Medicine. 2023 Sep;29(9):2358-2365. doi: 10.1038/s41591-023-02526-x. PMID: 37635157

Semaglutide in patients with heart failure with preserved ejection fraction and obesity. Kosiborod M, Abildstrom S, Borlaug B, Butler J, Rasmussen S, Davies M, Hovingh G, Kitzman D, Lindegaard M, Moller D, Shah S, Treppendahl M, Verma S, Abhayaratna W, Ahmed F, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovsky V, Merkely B, Nunez J, Perna E, Schou M, Senni M, Sharma K, Van der Meer P, von Lewinski D, Wolf D, Petrie M. New England Journal of Medicine. 2023 Sep 21;389(12):1069-1084. doi: 10.1056/NEJMoa2306963. PMID: 37622681

Semaglutide in patients with obesity and heart failure across mildly reduced or preserved ejection fraction. Butler J, Abildstrøm SZ, Borlaug BA, Davies MJ, Kitzman DW, Petrie MC, Shah SJ, Verma S, Abhayaratna WP, Chopra V, Ezekowitz JA, Fu M, Ito H, Lelonek M, Núñez J, Perna E, Schou M, Senni M, van der Meer P, von Lewinski D, Wolf D, Altschul RL, Rasmussen S, Kosiborod MN. Journal of the American College of Cardiology. 2023 Nov 28;82(22):2087-2096. doi: 10.1016/j.jacc.2023.09.811. PMID: 37993201

Short-course high-intensity statin treatment during admission for myocardial infarction and LDL-cholesterol reduction-impact on tailored lipid-lowering therapy at discharge. Marcos-Garces V, Merenciano-Gonzalez H, Martinez Mas M, Palau P, Climent Alberola J, Perez N, Lopez-Bueno L, Esteban Argente M, Valls Reig M, Munoz Alcover R, Pradillas Contreras I, Arizon Benito A, Paya Rubio A, Rios-Navarro C, de Dios E, Gavara J, Chorro F, Sanchis J, Bodi V. Journal of Clinical Medicine. 2023 Dec 25;13(1):127. doi: 10.3390/jcm13010127. PMID: 38202134

Short-term changes in hemoglobin and changes in functional status, quality of life, and natriuretic peptides after initiation of dapagliflozin in heart failure with reduced ejection fraction. Lorenzo M, Minana G, Palau P, Amiguet M, Seller J, Pinilla J, Dominguez E, Villar S, de la Espriella R, Nunez E, Gorriz J, Valle A, Bodi V, Sanchis J, Bayes-Genis A, Nunez J. Journal of Cardiac Failure. 2023 May;29(5):849-854. doi: 10.1016/j.cardfail.2023.02.008. PMID: 36871614

Short-term changes in klotho and FGF23 in heart failure with reduced ejection fraction-a substudy of the DAPA-VO2 study. Mora-Fernández C, Pérez A, Mollar A, Palau P, Amiguet M, de la Espriella R, Sanchis J, Górriz J, Soler M, Navarro-González J, Núñez J. Frontiers in Cardiovascular Medicine. 2023 Aug 25:10:1242108. doi: 10.3389/fcvm.2023.1242108. PMID: 37745119

Short-term changes in peak VO2 after initiation of dapagliflozin in heartfailure across iron status. Lorenzo M, Jacobs-Cachá C, Palau P, Amiguet M, Seller J, Núñez E, Espriella R, Górriz JL, Miñana G, Sanchis J, Bayés-Genis A, Soler MJ, Packer M, Núñez J; DAPA-VO2 Investigators. JACC. Heart Failure. 2023 Nov;11(11):1611-1622. doi: 10.1016/j.jchf.2023.07.010. PMID: 37676213

Should we banish morphine from the treatment of acute pulmonary oedema?. Lorenzo M, Nunez J. Emergencias. 2023 Feb;35(1):4-5. PMID: 36756910‘ target=’_blank’>36756910

Spot urinary sodium as a biomarker of diuretic response in acute heart failure. Oliva-Damaso N, Nunez J, Soler M. Journal of the American Heart Association. 2023 Sep 5;12(17):e030044. doi: 10.1161/JAHA.123.030044. PMID: 37609987

Sudden cardiac death in heart failure: a 20-year perspective from a mediterranean cohort. Codina P, Zamora E, Levy W, Cediel G, Santiago-Vacas E, Domingo M, Ruiz-Cueto M, Casquete D, Sarrias A, Borrellas A, Santesmases J, de la Espriella R, Nunez J, Aimo A, Lupon J, Bayes-Genis A. Journal of Cardiac Failure. 2022 Dec 12;S1071-9164(22)01222-2. doi: 10.1016/j.cardfail.2022.11.016. PMID: 36521725

The effect of an abdominopelvic exercise program alone VS in addition to postural instructions on pelvic floor muscle function in climacteric women with stress urinary incontinence. A randomized controlled trial. Fuentes-Aparicio L, Rejano-Campo M, Lopez-Bueno L, Donnelly G, Balasch-Bernat M. Physiotherapy Theory and Practice. 2023 Apr;39(4):738-749. doi: 10.1080/09593985.2022.2028323. PMID: 35068328

The influence of body mass index on clinical interpretation of established and novel biomarkers in acute heart failure. Horiuchi Y, Wettersten N, van Veldhuisen D, Mueller C, Nowak R, Hogan C, Kontos M, Cannon C, Birkhahn R, Vilke G, Mahon N, Nunez J, Briguori C, Duff S, Murray P, Maisel A. Journal of Cardiac Failure. 2023 Aug;29(8):1121-1131. doi: 10.1016/j.cardfail.2023.03.029. PMID: 37127240

Usefulness of urinary potassium to creatinine ratio to predict diuretic response in patients with acute heart failure and preserved ejection fraction. Llacer P, Nunez J, Croset F, Garcia M, Fabregate M, Ruiz R, Lopez G, Fernandez C, Del Hoyo B, Campos J, Gomis A, Manzano L. Clinical Cardiology. 2023 Aug;46(8):906-913. doi: 10.1002/clc.24040. PMID: 37287326

Valvular heart disease in patients on kidney replacement therapy: opening Pandora’s box. De la Espriella R, Romero-Gonzalez G, Nunez J. Clinical Kidney Journal. 2023 May 26;16(7):1045-1048. doi: 10.1093/ckj/sfad060. PMID: 37398695

Antithrombotic therapy in elderly patients with acute coronary síndromes. Bonanad C, Esteve-Claramunt F, Garcia-Blas S, Ayesta A, Diez-Villanueva P, Perez-Rivera J, Ferreiro J, Canoves J, Lopez-Fornas F, Sole A, Raposerias S, Vivas D, Blanco R, Berroteran D, Cordero A, Nunez J, Facila L, Nunez-Gil I, Gorriz J, Bodi V, Martinez-Selles M, Nodar J, Chorro F. Journal of Clinical Medicine. 2022 May 26;11(11):3008. doi: 10.3390/jcm11113008. PMID: 35683397

Applicability of echocardiographic strict negative criteria for suspected infective endocarditis. Marcos-Garces V, Gabaldon-Perez A, Merenciano-Gonzalez H, Soler M, Lorenzo-Hernandez M, Nunez-Marin G, de la Espriella R, Bonanad C, Nunez J, Chorro FJ, Bodi V, Santas E. American Journal of Cardiology. 2022 Jan 1;162:156-162. doi: 10.1016/j.amjcard.2021.09.012. PMID: 34728063

Bending Oxygen Saturation Index (BOSI) and risk of worsening heart failure events in chronic heart failure. de la Espriella R, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Dec;24(12):2390-2391. doi: 10.1002/ejhf.2692. PMID: 36102193

Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure. de la Espriella R, Amiguet M, Minana G, Rodriguez JC, Moyano P, Segarra D, Fernandez J, Santas E, Nunez G, Lorenzo M, Bonanad C, Alania E, Valle A, Sanchis J, Bodi V, Gorriz JL, Navarro J, Codina P, Voors AA, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Nov;24(11):2108-2117. doi: 10.1002/ejhf.2651. PMID: 36054502

Beta-blocker use in patients with heart failure with preserved ejection fraction and sinus rhythm. Formiga F, Chivite D, Nunez J, Moreno Garcia MC, Manzano L, Arevalo-Lorido JC, Cerqueiro JM, Garcia Campos A, Trullas JC, Montero-Perez-Barquero M. Revista Portuguesa de Cardiología. 2022 Oct;41(10):853-861. doi: 10.1016/j.repc.2021.06.027. PMID: 36207068

Bioactive or drug eluting stents in 75 years or older patients: the BIODES-75 Registry. Cordoba-Soriano J, Gutierrez-Diez A, Del Blanco B, Nunez J, Amat-Santos I, Oteo J, Romaguera R, Gallardo-Lopez A, Lozano Ruiz-Poveda F, Baello P, Aguar P, Jerez-Valero M, Jimenez-Diaz V, Serra B, Cascon J, Morales-Ponce F, Portero-Portaz J, Melehi El Assali D, Cerrato-Garcia P, Jimenez-Mazuecos J. Cardiovascular Revascularization Medicine: including molecular interventions. 2022 Sep;42:114-120. doi: 10.1016/j.carrev.2022.02.001. PMID: 35151602

Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology. Bayes-Genis A, Aimo A, Jhund P, Richards M, de Boer RA, Arfsten H, Fabiani I, Lupon J, Anker SD, Gonzalez A, Castiglione V, Metra M, Mueller C, Nunez J, Rossignol P, Barison A, Butler J, Teerlink J, Filippatos G, Ponikowski P, Vergaro G, Zannad F, Seferovic P, Rosano G, Coats AJS, Emdin M, Januzzi, JL. European Journal of Heart Failure. 2022 Oct;24(10):1767-1777. doi: 10.1002/ejhf.2675. PMID: 36073112

Carbohydrate antigen 125 (CA125) as a prognostic marker in the elderly with acute heart failure and preserved ejection fraction. Llacer P, Nunez J, Manzano L, Rodrigo J, Bautista P, Garcia M, Vila J, Lopez R, Reboiro M, Montero-Perez-Barquero M. Medicina Clinica. 2022 Aug 26;159(4):164-170. doi: 10.1016/j.medcli.2021.09.032. PMID: 34895749

Carbohydrate antigen 125 and risk of heart failure readmissions in patients with heart failure and preserved ejection fraction. Minana G, de la Espriella R, Palau P, Llacer P, Nunez E, Santas E, Valero E, Lorenzo M, Nunez G, Bodi V, Heredia R, Sanchis J, Bayes-Genis A, Chorro F, Nunez J. Scientific Reports. 2022 Jan 25;12(1):1344. doi: 10.1038/s41598-022-05328-2. PMID: 35079082

Cardiac remodelling part 1: from cells and tissues to circulating biomarkers. Gonzalez A, Richards A, de Boer R, Thum T, Arfsten H, Hulsmann M, Falcao-Pires I, Diez J, Foo R, Chan M, Aimo A, Anene-Nzelu G, Abdelhamid M, Adamopoulos S, Anker S, Belenkov Y, Gal T, Cohen-Solal A, Bohm M, Chioncel O, Delgado V, Emdin M, Jankowska E, Gustafsson F, Hill L, Jaarsma T, Januzzi J, Jhund P, Lopatin Y, Lund L, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Nunez J, Piepoli M, Rakisheva A, Ristic A, Rossignol P, Savarese G, Tocchetti C, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats A, Bayes-Genis A. European Journal of Heart Failure. 2022 Jun;24(6):927-943. doi: 10.1002/ejhf.2493. PMID: 35334137

Cardiac remodelling-Part 2: clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology. Aimo A, Vergaro G, Gonzalez A, Barison A, Lupon J, Delgado V, Richards AM, de Boer RA, Thum T, Arfsten H, Hulsmann M, Falcao-Pires I, Diez J, Foo RSY, Chan MYY, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Gal TB, Cohen-Solal A, Bohm M, Chioncel O, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund P, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Nunez J, Piepoli MF, Rakisheva A, Ristic AD, Rossignol P, Savarese G, Tocchetti CG, van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJS, Emdin M, Bayes-Genis A. European Journal of Heart Failure. 2022 Jun;24(6):944-958. doi: 10.1002/ejhf.2522. PMID: 35488811

Circulating miRNA fingerprint and endothelial function in myocardial infarction: comparison at acute event and one-year follow-up. Mompeon A, Perez-Cremades D, Paes A, Sanchis J, Ortega-Paz L, Andrea R, Brugaletta S, Sabate M, Novella S, Dantas A, Hermenegildo C. Cells. 2022 Jun 2;11(11):1823. doi: 10.3390/cells11111823. PMID: 35681518

Clinical characteristics and risk factors for mortality on admission in patients with heart failure hospitalized due to COVID-19 in Spain. Llacer Iborra P, Nunez Villota J. Revista Clinica Española. 2022 May;222(5):299-300. doi: 10.1016/j.rceng.2022.02.002. PMID: 35512909

Clinical characteristics and risk factors for mortality on admission in patients with heart failure hospitalized due to COVID-19 in Spain. Llacer P, Nunez J. Revista Clinica Española. 2022 May;222(5):299-300. doi: 10.1016/j.rce.2022.02.006. PMID: 35250040

Clinical recommendations to manage gastrointestinal adverse events in patients treated with Glp-1 receptor agonists: a multidisciplinary expert consensus. Gorgojo-Martinez JJ, Mezquita-Raya P, Carretero-Gomez J, Castro A, Cebrian-Cuenca A, De Torres-Sanchez A, Garcia-de-Lucas MD, Nunez J, Obaya JC, Soler MJ, Gorriz JL, Rubio-Herrera MA. Journal of Clinical Medicine. 2022 Dec 24;12(1):145. doi: 10.3390/jcm12010145. PMID: 36614945

Combined assessment of stress cardiovascular magnetic resonance and angiography to predict the effect of revascularization in chronic coronary syndrome patients. Gavara J, Perez N, Marcos-Garces V, Monmeneu J, Lopez-Lereu M, Rios-Navarro C, de Dios E, Bonanad C, Canoves J, Moratal D, Palau P, Minana G, Nunez J, Chorro F, Bodi V. European Journal of Preventive Cardiology. 2022 Mar 11;29(2):407-416. doi: 10.1093/eurjpc/zwab170. PMID: 34686874

Comments on the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. SEC Working Group for the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure and SEC Guidelines Committee. Revista Espanola De Cardiologia (english Ed.). 2022 Jun;75(6):458-465. doi: 10.1016/j.rec.2021.11.023. PMID: 35190290

Comparison of chlorthalidone and spironolactone as additional diuretic therapy in patients with acute heart failure and preserved ejection fraction. Llacer P, Nunez J, Garcia M, Ruiz R, Lopez G, Fabregate M, Fernandez C, Croset F, Del Hoyo B, Gomis A, Manzano L. European Heart Journal. Acute Cardiovascular Care. 2022 Jun 7;11(4):350-355. doi: 10.1093/ehjacc/zuac006. PMID: 35167653

Congestion in heart failure: a circulating biomarker-based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology. Nunez J, de la Espriella R, Rossignol P, Voors AA, Mullens W, Metra M, Chioncel O, Januzzi JL, Mueller C, Richards AM, de Boer RA, Thum T, Arfsten H, Gonzalez A, Abdelhamid M, Adamopoulos S, Anker SD, Gal TB, Biegus J, Cohen-Solal A, Boehm M, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Jhund PS, Lopatin Y, Lund LH, Milicic D, Moura B, Piepoli MF, Ponikowski P, Rakisheva A, Ristic A, Savarese G, Tocchetti CG, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJS, Bayes-Genis A. European Journal of Heart Failure. 2022 Oct;24(10):1751-1766. doi: 10.1002/ejhf.2664. PMID: 36039656

Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. Solomon S, McMurray J, Claggett B, de Boer R, DeMets D, Hernandez A, Inzucchi S, Kosiborod M, Lam C, Martinez F, Shah S, Desai A, Jhund P, Belohlavek J, Chiang C, Borleffs C, Comin-Colet J, Dobreanu D, Drozdz J, Fang J, Alcocer-Gamba M, Al Habeeb W, Han Y, Honorio J, Janssens S, Katova T, Kitakaze M, Merkely B, O’Meara E, Saraiva J, Tereshchenko S, Thierer J, Vaduganathan M, Vardeny O, Verma S, Pham V, Wilderang U, Zaozerska N, Bachus E, Lindholm D, Petersson M, Langkilde A. New England Journal of Medicine. 2022 Sep 22;387(12):1089-1098. doi: 10.1056/NEJMoa2206286. PMID: 36027570

Decongestion, kidney injury and prognosis in patients with acute heart failure. Horiuchi Y, Wettersten N, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Mueller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Duff S, Maisel A, Murray PT. International Journal of Cardiology. 2022 May 1;354:29-37. doi: 10.1016/j.ijcard.2022.02.026. PMID: 35202737

Dysglycaemia and high natriuretic peptides: the prelude to heart failure. Bayes-Genis A, Nunez J, Lupon J. European Journal of Heart Failure. 2022 Feb;24(2):254-256. doi: 10.1002/ejhf.2410. PMID: 34957645

Early carbohydrate antigen 125 as a mortality predictor in hospitalized patients with coronavirus disease 2019. Moreno-Perez O, Nunez J, Sandin-Rollan M, Arrarte V, Boix V, Reus S, Pinargote-Celorio H, Ribes I, Alfayate R, Llorca-Santos M, Martinez-Garcia M, Chico-Sanchez P, Merino E. Frontiers In Cardiovascular Medicine. 2022 Oct 20;9:941512. doi: 10.3389/fcvm.2022.941512. PMID: 36337886

Effect of a home-based inspiratory muscle training programme on functional capacity in postdischarged patients with long COVID: the InsCOVID trial. Palau P, Dominguez E, Gonzalez C, Bondia E, Albiach C, Sastre C, Martinez M, Nunez J, Lopez L. BMJ Open Respiratory Research. 2022 Dec;9(1):e001439. doi: 10.1136/bmjresp-2022-001439. PMID: 36549786

Effect of a home-based inspiratory muscular training programme on functional capacity in patients with chronic COVID-19 after a hospital discharge: protocol for a randomised control trial (InsCOVID trial). Palau P, Dominguez E, Sastre C, Martinez M, Gonzalez C, Bondia E, Albiach C, Nunez J, Lopez L. BMJ Open Respiratory Research. 2022 Jul;9(1):e001255. doi: 10.1136/bmjresp-2022-001255. PMID: 35790316

Efficacy and safety of subcutaneous infusion of non-formulated furosemide in patients with worsening heart failure: a real-world study. Civera J, de la Espriella R, Heredia R, Minana G, Santas E, Conesa A, Mollar A, Sastre C, Martinez A, Villaescusa A, Nunez J. Journal of Cardiovascular Translational Research. 2022 Jun;15(3):644-652. doi: 10.1007/s12265-021-10173-1. PMID: 34642870

EpCAM and microvascular obstruction in patients with STEMI: a cardiac magnetic resonance study. Rios-Navarro C, Gavara J, Nunez J, Revuelta-Lopez E, Monmeneu JV, Lopez-Lereu MP, de Dios E, Perez-Sole N, Vila JM, Oltra R, Chorro FJ, Bayes-Genis A, Bodi V. Revista Espanola de Cardiologia (English ed.). 2022 May;75(5):384-391. doi: 10.1016/j.rec.2021.04.006. PMID: 34045168

Evaluation of the effect of intravenous nitroglycerine on short-term survival of patients with acute heart failure according to congestion and perfusion status at emergency department arrival. Miro O, Espinosa B, Gil V, Jacob J, Alquezar-Arbe A, Masip J, Llauger L, Tost J, Andueza J, Garrido J, Mojarro E, Urbano C, Nunez J, Chioncel O, Mullens W, Cotter G, Llorens P. European Journal of Emergency Medicine. 2022 Dec 1;29(6):437-449. doi: 10.1097/MEJ.0000000000000964. PMID: 35861663

Fourier analysis of collagen bundle orientation in myocardial infarction scars. Marcos-Garces V, Rios-Navarro C, Gomez-Torres F, Gavara J, de Dios E, Diaz A, Minana G, Chorro F, Bodi V, Ruiz-Sauri A. Histochemistry and Cell Biology. 2022 Nov;158(5):471-483. doi: 10.1007/s00418-022-02132-x. PMID: 35948735

Frailty and hospitalization burden in patients with chronic heart failure. Mollar A, Bonanad C, Diez-Villanueva P, Segarra D, Civera J, Sastre C, Conesa A, Villaescusa A, Fernández J, Miñana G, Navarro J, Sanchis J, Núñez J. American Journal of Cardiology. 2022 Nov 15;183:48-54. doi: 10.1016/j.amjcard.2022.08.013. PMID: 36153181

Global warming, renal function and heart failure over 20years. Aimo A, Lupon J, Spitaleri G, Domingo M, Codina P, Santiago-Vacas E, Cediel G, Zamora E, Troya M, Santesmases J, Romero-Gonzalez G, Nunez J, Martini N, Emdin M, Bayes-Genis A. International Journal of Cardiology. 2022 Oct 15;365:100-105. doi: 10.1016/j.ijcard.2022.07.043. PMID: 35926642

Head-to-head comparison between recommendations by the ESC and ACC/AHA/HFSA Heart Failure Guidelines. Bayes-Genis A, Aimo A, Metra M, Anker S, Seferovic P, Rapezzi C, Castiglione V, Nunez J, Emdin M, Rosano G, Coats AJs. European Journal of Heart Failure. 2022 Jun;24(6):916-926. doi: 10.1002/ejhf.2542. PMID: 35579428

Histone citrullination mediates a protective role in endothelium and modulates inflammation. Osca-Verdegal R, Beltran-Garcia J, Paes A, Nacher-Sendra E, Novella S, Hermenegildo C, Carbonell N, Garcia-Gimenez J, Pallardo F. Cells. 2022 Dec 15;11(24):4070. doi: 10.3390/cells11244070. PMID: 36552833

Hospitalization following an emergency-department visit for worsening heart failure: the role of left ventricular ejection fraction. Mollar A, Lorenzo M, Villaescusa A, Heredia R, Minana G, Santas E, de la Espriella R, Sastre C, Civera J, Martinez A, Conesa A, Sanchis J, Nunez E, Bayes-Genis A, Nunez J. Medicina Clinica. 2022 Aug 26;159(4):157-163. doi: 10.1016/j.medcli.2021.09.026. PMID: 35065819

Importance of frequency and intensity of strength training for work ability among physical therapists. Calatayud J, Morera A, Ezzatvar Y, Lopez-Bueno R, Andersen LL, Cuenca-Martinez F, Suso-Marti L, Sanchis-Sanchez E, Lopez-Bueno L, Casana J. Scientific Reports. 2022 Sep 2;12(1):15016. doi: 10.1038/s41598-022-18539-4. PMID: 36056040

Incidence, treatment and clinical impact of iron deficiency in chronic heart failure: a longitudinal analysis. Minana G, Lorenzo M, Ramirez de Arellano A, Wachter S, de la Espriella R, Sastre C, Mollar A, Nunez E, Bodi V, Sanchis J, Bayes-Genis A, Nunez J. Journal of Clinical Medicine. 2022 May 2;11(9):2559. doi: 10.3390/jcm11092559. PMID: 35566684

Individualizing the treatment of patients with heart failure with reduced ejection fraction: a journey from hospitalization to long-term outpatient care. Escobar C, Luis-Bonilla J, Crespo-Leiro M, Esteban-Fernandez A, Farre N, Garcia A, Nunez J. Expert Opinion on Pharmacotherapy. 2022 Oct;23(14):1589-1599. doi: 10.1080/14656566.2022.2116275. PMID: 35995759

Light at the end of the tunnel of preserved heart failure, although important improvements are still necessary. Nunez J, de la Espriella R, Formiga F. Revista Portuguesa de Cardiología. 2022 Oct;41(10):897-898. doi: 10.1016/j.repc.2022.01.008. PMID: 36207070

Long-term mortality and trajectory of potassium measurements following an episode of acute severe hyperkalemia. Gorriz J, D’Marco L, Pastor-Gonzalez A, Molina P, Gonzalez-Rico M, Puchades M, Sanchis I, Escudero V, Estan N, de la Espriella R, Nunez E, Pallardo L, Nunez J. Nephrology, dialysis, transplantation. 2022 Feb 25;37(3):522-530. doi: 10.1093/ndt/gfab003. PMID: 33508124

Long-term prognostic impact of estimated glomerular filtration rate on admission in patients hospitalized for acute heart failure. de la Espriella R, Navarro J, Mollar A, D’Marco L, Palau P, Minana G, Llacer P, Santas E, Heredia R, Gonzalez M, Gorriz JL, Codina P, Diez J, Bayes-Genis A, Nunez J. Cardiorenal Medicine. 2022;12(4):179-188. doi: 10.1159/000526105. PMID: 36282062

Magnetic resonance assessment of left ventricular ejection fraction at any time post-infarction for prediction of subsequent events in a large multicenter STEMI Registry. Gavara J, Marcos-Garces V, Lopez-Lereu, MP, Monmeneu JV, Rios-Navarro C, de Dios E, Perez N, Merenciano H, Gabaldon A, Canoves J, Racugno P, Bonanad C, Minana G, Nunez J, Nunez E, Moratal D, Chorro FJ, Valente F, Lorenzatti D, Rodriguez-Palomares JF, Ortiz-Perez JT, Bodi V. Journal of Magnetic Resonance Imaging. 2022 Aug;56(2):476-487. doi: 10.1002/jmri.27789. PMID: 34137478

Mortality and heart failure risk reductions in patients treated with sacubitril-valsartan in clinical trials. Cordero A, Nunez J, Bertomeu-Gonzalez V, Facila L, Quintanilla M, Rodriguez-Manero M, Escribano D, Valle A, de la Espriella R, Torres-Llergo J, Bayes-Genis A, Gonzalez-Juanatey J. American Journal of Therapeutics. 2022 Sep-Oct 01;29(5):e572-e575. doi: 10.1097/MJT.0000000000001503. PMID: 36074989

Mortality risk prediction dynamics after heart failure treatment optimization: repeat risk assessment using online risk calculators. Codina P, Zamora E, Levy W, Revuelta-Lopez E, Borrellas A, Spitaleri G, Cediel G, Ruiz-Cueto M, Canedo E, Santiago-Vacas E, Domingo M, Buchaca D, Subirana I, Santesmases J, de la Espriella R, Nunez J, Lupon J, Bayes-Genis A. Frontiers In Cardiovascular Medicine. 2022 Apr 12;9:836451. doi: 10.3389/fcvm.2022.836451. PMID: 35498033

Optimal carbohydrate antigen 125 cutpoint for identifying low-risk patients after admission for acute heart failure. Nunez J, Bayes-Genis A, Revuelta-Lopez E, Minana G, Santas E, Ter Maaten J, de la Espriella R, Carratala A, Lorenzo M, Palau P, Llacer P, Valle A, Bodi V, Nunez E, Lupon J, Lang C, Ng L, Metra M, Sanchis J, Voors A. Revista Espanola de Cardiologia (english Ed.). 2022 Apr;75(4):316-324. doi: 10.1016/j.rec.2021.02.002. PMID: 33745912

Plaque modification in calcified chronic total occlusions: the PLACCTON study. Delgado-Arana J, Rumoroso J, Regueiro A, Martin-Moreiras J, Minana G, Mohandes M, Pan M, Salinas P, Caballero-Borrego J, Fernandez-Diaz J, Jurado-Roman A, Lacunza J, Vaquerizo B, Rivero F, Abellan-Huerta J, Rondan J, Gomez Menchero A, Santos-Martinez S, Subinas A, Arevalos V, Diego Nieto A, Sanchis J, Rojas S, Ojeda S, Gonzalo N, Lopez-Perez M, Goicolea J, Sadaba M, Gomez-Salvador I, Sabate M, Nunez Garcia J, Amat-Santos I. Revista Espanola de Cardiologia (english Ed.). 2022 Mar;75(3):213-222. doi: 10.1016/j.rec.2021.06.011. PMID: 34301507

Prognostic value of cardiac magnetic resonance early after ST-segment elevation myocardial infarction in older patients. Gabaldón-Pérez A, Marcos-Garcés V, Gavara J, López-Lereu MP, Monmeneu JV, Pérez N, Ríos-Navarro C, De Dios E, Merenciano-González H, Cànoves J, Racugno P, Bonanad C, Minana G, Núnez J, Moratal D, Chorro FJ, Valente F, Lorenzatti D, Ortiz-Pérez JT, Rodríguez-Palomares JF, Bodí V. Age and Ageing. 2022 Nov 2;51(11):afac248. doi: 10.1093/ageing/afac248. PMID: 36436010

Prognostic value of NT-proBNP and CA125 across glomerular filtration rate categories in acute heart failure. De la Espriella R, Bayes-Genis A, Llacer P, Palau P, Minana G, Santas E, Pellicer M, Gonzalez M, Gorriz JL, Bodi V, Sanchis J, Nunez J. European Journal of Internal Medicine. 2022 Jan;95:67-73. doi: 10.1016/j.ejim.2021.08.024. PMID: 34507853

Rationale and design of the dapagliflozin after transcatheter aortic valve implantation (DapaTAVI) randomized trial. Amat-Santos I, Sanchez-Luna J, Abu-Assi E, Melendo Viu M, Cruz-Gonzalez I, Nombela-Franco L, Munoz Garcia A, Garcia Blas S, de la Torre Hernandez J, Romaguera R, Sanchez-Recalde A, Diez Gil J, Lopez Otero D, Gheorge L, Ibanez B, Iniguez Romo A, Raposeiras-Roubin S, Dapagliflozin after Transcatheter Aortic Valve Implantation (DapaTAVI), investigators. European Journal of Heart Failure. 2022 Mar;24(3):581-588. doi: 10.1002/ejhf.2370. PMID: 34693613

Reply to the Letter regarding the article ‘Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure. de la Espriella R, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Dec;24(12):2391-2392. doi: 10.1002/ejhf.2717. PMID: 36225111

Reply to the Letter to the Editor to the article Comparison between CA125 and NT-proBNP for evaluating congestion in acute heart failure. Llacer P, Manzano L, Nunez J. Medicina Clinica. 2022 Jul 8;159(1):e2. doi: 10.1016/j.medcli.2022.01.023. PMID: 35545477

Reply: Beta-blocker withdrawal and chronotropic incompetence in heart failure with preserved ejection fraction. Palau P, Seller J, Domínguez E, Bayés-Genís A, Núñez J. Journal of the American College of Cardiology. 2022 Mar 8;79(9):e197-e198. doi: 10.1016/j.jacc.2022.01.002. PMID: 35241230

Risk score for early risk prediction by cardiac magnetic resonance after acute myocardial infarction. Marcos-Garces V, Perez N, Gavara J, Lopez-Lereu MP, Monmeneu JV, Rios-Navarro C, de Dios E, Merenciano-Gonzalez H, Gabaldon-Perez A, Canoves J, Racugno P, Bonanad C, Minana G, Nunez J, Moratal D, Chorro FJ, Valente F, Lorenzatti D, Ortiz-Perez JT, Rodriguez-Palomares JF, Bodi V. International Journal of Cardiology. 2022 Feb 15;349:150-154. doi: 10.1016/j.ijcard.2021.11.050. PMID: 34826497

Sacubitril/valsartan affects pulmonary arterial pressure in heart failure with preserved ejection fraction and pulmonary hypertension. Codina P, Domingo M, Barcelo E, Gastelurrutia P, Casquete D, Vila J, Altisent O, Spitaleri G, Cediel G, Santiago-Vacas E, Zamora E, Ruiz-Cueto M, Santesmases J, de la Espriella R, Pascual-Figal D, Nunez J, Lupon J, Bayes-Genis A. ESC Heart Failure. 2022 Aug;9(4):2170-2180. doi: 10.1002/ehf2.13952. PMID: 35588235

Serum potassium dynamics during acute heart failure hospitalization. Caravaca Perez P, Gonzalez-Juanatey J, Nuche J, Moran Fernandez L, Lora Pablos D, Alvarez-Garcia J, Bascompte Claret R, Martinez Selles M, Vazquez Garcia R, Martinez Dolz L, Cobo-Marcos M, Pascual Figal D, Crespo-Leiro M, Nunez Villota J, Cinca Cuscullola J, Delgado J. Clinical Research in Cardiology. 2022 Apr;111(4):368-379. doi: 10.1007/s00392-020-01753-3. PMID: 33070219

Sex effect in the decision to perform invasive coronary angiography in patients with chronic coronary syndrome after undergoing vasodilator stress MRI. Palau P, Nunez J, Monmeneu J, Lopez-Lereu M, Gavara J, Rios-Navarro C, de Dios E, Perez-Sole N, Marcos-Garces V, Dominguez E, Moratal D, Canoves J, Minana G, Chorro F, Bodi V. Journal of Magnetic Resonance Imaging. 2022 Dec;56(6):1680-1690. doi: 10.1002/jmri.28163. PMID: 35344231

Sex-related differences in mortality following admission for acute heart failure across the left ventricular ejection fraction spectrum. Santas E, Palau P, Llacer P, de la Espriella R, Minana G, Nunez-Marin G, Lorenzo M, Heredia R, Sanchis J, Chorro FJ, Bayes-Genis A, Nunez J. Journal of the American Heart Association. 2022 Jan 4;11(1):e022404. doi: 10.1161/JAHA.121.022404. PMID: 34927464

Short-term changes in left and right ventricular cardiac magnetic resonance feature tracking strain following ferric carboxymaltose in patients with heart failure: a substudy of the Myocardial-IRON Trial. Del Canto I, Santas E, Cardells I, Minana G, Palau P, Llacer P, Facila L, Lopez-Vilella R, Almenar L, Bodi V, Lopez-Lereu M, Monmeneu J, Sanchis J, Moratal D, Maceira A, de la Espriella R, Chorro F, Bayes-Genis A, Nunez J. Journal of the American Heart Association. 2022 Apr 5;11(7):e022214. doi: 10.1161/JAHA.121.022214. PMID: 35301854

Short-term effects of dapagliflozin on maximal functional capacity in heart failure with reduced ejection fraction (DAPA-VO2): a randomized clinical trial. Palau P, Amiguet M, Dominguez E, Sastre C, Mollar A, Seller J, Pinilla J, Larumbe A, Valle A, Doblas J, de la Espriella R, Minana G, Mezcua A, Santas E, Bodi V, Sanchis J, Pascual-Figal D, Gorriz J, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Oct;24(10):1816-1826. doi: 10.1002/ejhf.2560. PMID: 35604416

Stress cardiac magnetic resonance for mortality prediction and decision-making: registry of 2496 elderly patients with chronic coronary syndrome. Gabaldon-Perez A, Bonanad C, Garcia-Blas S, Gavara J, Rios-Navarro C, Perez-Sole N, de Dios E, Marcos-Garces V, Merenciano-Gonzalez H, Monmeneu J, Lopez-Lereu M, Nunez J, Chorro F, Bodi V. Revista Espanola de Cardiologia (english Ed.). 2022 Mar;75(3):223-231. doi: 10.1016/j.rec.2021.08.004. PMID: 34548244

Utility of plasma CA125 as a proxy of intra-abdominal pressure in patients with acute heart failure. Rubio-Gracia J, Crespo-Aznarez S, De la Espriella R, Nunez G, Sanchez-Marteles M, Garces-Horna V, Yanguas-Barea N, Josa-Laorden C, Cobo-Marcos M, Gimenez-Lopez I, Perez-Calvo JI, Nunez J. European Heart Journal-Acute Cardiovascular Care. 2022 Jun 22;11(6):453-460. doi: 10.1093/ehjacc/zuac046. PMID: 35512321

Venous leg compression for tissue decongestion in patients with worsening congestive heart failure. Civera J, Minana G, de la Espriella R, Santas E, Sastre C, Mollar A, Conesa A, Martinez A, Nunez E, Bayes-Genis A, Nunez J. Frontiers In Cardiovascular Medicine. 2022 Jul 8;9:847450. doi: 10.3389/fcvm.2022.847450. PMID: 35872894

Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review. Nunez J, de la Espriella R, Minana G, Santas E, Llacer P, Nunez E, Palau P, Bodi V, Chorro F, Sanchis J, Lupon J, Bayes-Genis A. European Journal of Heart Failure. 2021 Sep;23(9):1445-1457. doi: 10.1002/ejhf.2295. PMID: 34241936

Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure. Mollar A, Marrachelli V, Nunez E, Monleon D, Bodi V, Sanchis J, Navarro D, Nunez J. Scientific reports. 2021 Mar 17;11(1):6110. doi: 10.1038/s41598-021-85527-5. PMID: 33731747

CA125 but not NT-proBNP predicts the presence of a congestive intrarenal venous flow in patients with acute heart failure. Nunez-Marin G, de la Espriella R, Santas E, Lorenzo M, Minana G, Nunez E, Bodi V, Gonzalez M, Gorriz J, Bonanad C, Sanchis J, Bayes-Genis A, Nunez J. European Heart Journal-Acute Cardiovascular Care. 2021 Jun 30;10(5):475-483. doi: 10.1093/ehjacc/zuab022. PMID: 33829233

Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure. Teerlink J, Diaz R, Felker G, McMurray J, Metra M, Solomon S, Adams K, Anand I, Arias-Mendoza A, Biering-Sorensen T, Bohm M, Bonderman D, Cleland J, Corbalan R, Crespo-Leiro M, Dahlstrom U, Echeverria L, Fang J, Filippatos G, Fonseca C, Goncalvesova E, Goudev A, Howlett J, Lanfear D, Li J, Lund M, Macdonald P, Mareev V, Momomura S, O’Meara E, Parkhomenko A, Ponikowski P, Ramires F, Serpytis P, Sliwa K, Spinar J, Suter T, Tomcsanyi J, Vandekerckhove H, Vinereanu D, Voors A, Yilmaz M, Zannad F, Sharpsten L, Legg J, Varin C, Honarpour N, Abbasi S, Malik F, Kurtz C, GALACTIC-HF Investigators. New England Journal of Medicine. 2021 Jan 14;384(2):105-116. doi: 10.1056/NEJMoa2025797. PMID: 33185990

Cardiorespiratory fitness measured with cardiopulmonary exercise testing and mortality in patients with cardiovascular disease: A systematic review and meta-analysis. Ezzatvar Y, Izquierdo M, Nunez J, Calatayud J, Ramirez-Velez R, Garcia-Hermoso A. Journal of Sport and Health Science. 2021 Dec;10(6):609-619. doi: 10.1016/j.jshs.2021.06.004. PMID: 34198003

Choice of CTO scores to predict procedural success in clinical practice. A comparison of 4 different CTO PCI scores in a comprehensive national registry including expert and learning CTO operators. Salinas P, Gonzalo N, Moreno V, Fuentes M, Santos-Martinez S, Fernandez-Diaz J, Amat-Santos I, Ojeda F, Borrego J, Cuesta J, Hernandez J, Diego-Nieto A, Dubois D, Galeote G, Goicolea J, Gutierrez A, Jimenez-Fernandez M, Jimenez-Mazuecos J, Jurado A, Lacunza J, Lee D, Lopez M, Lozano F, Martin-Moreiras J, Martin-Yuste V, Millan R, Minana G, Mohandes M, Morales-Ponce F, Nunez J, Ojeda S, Pan M, Rivero F, Robles J, Rodriguez-Leiras S, Rojas S, Rondan J, Rumiz E, Sabate M, Sanchis J, Vaquerizo B, Escaned J. PLoS One. 2021 Apr 2;16(4):e0245898. doi: 10.1371/journal.pone.0245898. PMID: 33798205

Circulating neprilysin hypothesis: a new opportunity for sacubitril/valsartan in patients with heart failure and preserved ejection fraction?. Lupon J, Santiago-Vacas E, Cediel G, Codina P, Domingo M, Revuelta-Lopez E, Zamora E, Spitaleri G, Santesmases J, Nunez J, Bayes-Genis A. PLoS One. 2021 May 14;16(5):e0249674. doi: 10.1371/journal.pone.0249674. PMID: 33989294

Clinical history and detectable troponin concentrations below the 99th percentile for risk stratification of patients with chest pain and first normal troponin. Fernandez-Cisnal A, Valero E, Garcia-Blas S, Pernias V, Pozo A, Carratala A, Gonzalez J, Noceda J, Minana G, Nunez J, Sanchis J. Journal of Clinical Medicine. 2021 Apr 20;10(8):1784. doi: 10.3390/jcm10081784. PMID: 33923925

Clinical outcomes and response to vericiguat according to index heart failure event: insights from the VICTORIA trial. Lam C, Giczewska A, Sliwa K, Edelmann F, Refsgaard J, Bocchi E, Ezekowitz J, Hernandez A, O’Connor C, Roessig L, Patel M, Pieske B, Anstrom K, Armstrong P, VICTORIA Study Grp. JAMA Cardiology. 2021 Jun 1;6(6):706-712. doi: 10.1001/jamacardio.2020.6455. PMID: 33185650

Clinical utility of antigen carbohydrate 125 for planning the optimal length of stay in acute heart failure. Lorenzo M, Palau P, Llacer P, Dominguez E, Ventura B, Nunez G, Minana G, Solsona J, Santas E, De La Espriella R, Bodi V, Nunez E, Sanchis J, Bayes-Genis A, Nunez J. European Journal of Internal Medicine. 2021 Oct;92:94-99. doi: 10.1016/j.ejim.2021.05.037. PMID: 34130879

Comorbidity burden and revascularization benefit in elderly patients with acute coronary syndrome. Sanchis Fores J, Garcia Acuna J, Raposeiras S, Barrabes J, Cordero A, Martinez-Selles M, Bardaji A, Diez-Villanueva P, Marin F, Ruiz-Nodar J, Vicente-Ibarra N, Alonso Salinas G, Rigueiro P, Abu-Assi E, Formiga F, Nuñez Villota J, Nuñez Benito E, Ariza-Sole A. Revista Espanola de Cardiologia (English ed.). 2021 Sep;74(9):765-772. doi: 10.1016/j.rec.2020.06.015. PMID: 32778402

Comparison between CA125 and NT-proBNP for evaluating congestion in acute heart failure. Llacer P, Gallardo M, Palau Sampio P, Moreno M, Castillo C, Fernandez C, De La Espriella Juan R, Mollar Fernandez A, Santas Olmeda E, Miñana Escriva G, Manzano L, Bayes-Genis A, Nuñez Villota J. Medicina Clinica. 2021 Jun 25;156(12):589-594. doi: 10.1016/j.medcli.2020.05.063. PMID: 32951882

Coronary Revascularization and Long-Term Survivorship in Chronic Coronary Syndrome. Gabaldon-Perez A, Marcos-Garces V, Gavara J, Rios-Navarro C, Minana G, Bayes-Genis A, Husser O, Sanchis J, Nunez J, Chorro F, Bodi V. Journal of Clinical Medicine. 2021 Feb 5;10(4):610. doi: 10.3390/jcm10040610. PMID: 33562869

Decoding empagliflozin’s molecular mechanism of action in heart failure with preserved ejection fraction using artificial intelligence. Bayes-Genis A, Iborra-Egea O, Spitaleri G, Domingo M, Revuelta-Lopez E, Codina P, Cediel G, Santiago-Vacas E, Cserkoova A, Pascual-Figal D, Nunez J, Lupon J. Scientific Reports. 2021 Jun 8;11(1):12025. doi: 10.1038/s41598-021-91546-z. PMID: 34103605

Decongestion discriminates risk for one-year mortality in patients with improving renal function in acute heart failure. Wettersten N, Horiuchi Y, van Veldhuisen D, Ix J, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, Duff S, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, Murray P. European Journal of Heart Failure. 2021 Jul;23(7):1122-1130. doi: 10.1002/ejhf.2179. PMID: 33788989

Direct oral anticoagulants versus warfarin in octogenarians with nonvalvular atrial fibrillation: a systematic review and meta-analysis. Bonanad C, Garcia-Blas S, Torres Llergo J, Fernandez-Olmo R, Diez-Villanueva P, Ariza-Sole A, Martinez-Selles M, Raposeiras S, Ayesta A, Bertomeu-Gonzalez V, Tarazona Santabalbina F, Facila L, Vivas D, Gabaldon-Perez A, Bodi V, Nunez J, Cordero A. Journal of Clinical Medicine. 2021 Nov 12;10(22):5268. doi: 10.3390/jcm10225268. PMID: 34830548

Drug titration by nursing professionals in heart failure units. Civera JM, Conesa A, Villaescusa A, Nunez J. Revista Espanola de Cardiologia (English Ed.). 2021 Jun;74(6):561. doi: 10.1016/j.rec.2020.10.013. PMID: 33342715

Early urinary sodium trajectory and risk of adverse outcomes in acute heart failure and renal dysfunction. De La Espriella Juan R, Nuñez Benito E, Llàcer P, Garcia Blas S, Ventura Haro S, Núñez J, Sánchez R, Facila De La Esperanza R, Vaquer Santamaria J, Bodí Peris V, Santas Olmeda E, Miñana Escriva G, Mollar Fernandez A, Núñez Marín G, Chorro Gascó F, Górriz Teruel J, Sanchis Fores J, Bayés-Genis A, Nuñez Villota J. Revista Espanola de Cardiologia (English ed.). 2021 Jul;74(7):616-623. doi: 10.1016/j.rec.2020.06.004. PMID: 32624444

Effect of beta-blocker withdrawal on functional capacity in heart failure and preserved ejection fraction. Palau P, Seller J, Dominguez E, Sastre C, Ramon JM, Espriella R, Santas E, Minana G, Bodi V, Sanchis J, Valle A, Chorro FJ, Llacer P, Bayes-Genis A, Nunez J. Journal of the American College of Cardiology. 2021 Nov 23;78(21):2042-2056. doi: 10.1016/j.jacc.2021.08.073. PMID: 34794685

Effect of sotagliflozin on total hospitalizations in patients with type 2 diabetes and worsening heart failure: a randomized trial. Szarek M, Bhatt D, Steg P, Cannon C, Leiter L, McGuire D, Lewis J, Riddle M, Voors A, Metra M, Lund L, Komajda M, Testani J, Wilcox C, Ponikowski P, Lopes R, Banks P, Tesfaye E, Ezekowitz J, Verma S, Pitt B, SOLOIST-WHF Comm Investigators. Annals of Internal Medicine. 2021 Aug;174(8):1065-1072. doi: 10.7326/M21-0651. PMID: 34152828

Effects of empagliflozin on CA125 trajectory in patients with chronic congestive heart failure. de la Espriella R, Minana G, Santas E, Nunez G, Lorenzo M, Nunez E, Bayes-Genis A, Nunez J. International Journal of Cardiology. 2021 Sep 15;339:102-105. doi: 10.1016/j.ijcard.2021.06.045. PMID: 34216708

Frailty scales for prognosis assessment of older adult patients after acute myocardial infarction. Garcia-Blas S, Bonanad C, Fernandez-Cisnal A, Sastre-Arbona C, Ruescas-Nicolau M, D’Gregorio J, Valero E, Minana G, Palau P, Tarazona-Santabalbina F, Ros V, Nunez J, Sanchis J. Journal of Clinical Medicine. 2021 Sep 21;10(18):4278. doi: 10.3390/jcm10184278. PMID: 34575389

Head-to-head comparison of contemporary heart failure risk scores. Codina P, Lupon J, Borrellas A, Spitaleri G, Cediel G, Domingo M, Simpson J, Levy WC, Santiago-Vacas E, Zamora E, Buchaca D, Subirana I, Santesmases J, Diez-Quevedo C, Troya MI, Boldo M, Altmir S, Alonso N, Gonzalez B, Rivas C, Nunez J, McMurray J, Bayes-Genis A. European Journal of Heart Failure. 2021 Dec;23(12):2035-2044. doi: 10.1002/ejhf.2352. PMID: 34558158

Heart failure with preserved ejection fraction: an urgent need for precision medicine. Minana, G, Nunez J. Journal of Clinical Medicine. 2021 Apr 21;10(9):1801. doi: 10.3390/jcm10091801. PMID: 33918988

Homocysteine and long-term recurrent infarction following an acute coronary síndrome. Miñana Escriva G, Gil Cayuela C, Facila De La Esperanza R, Bodí Peris V, Valero Picher E, Mollar Fernandez A, Marco M, Garcia-Ballester T, Zorio B, Marti-Cervera J, Nuñez Benito E, Chorro Gascó F, Sanchis Fores J, Nuñez Villota J. Cardiology Journal. 2021;28(4):598-606. doi: 10.5603/CJ.a2020.0170. PMID: 33346372

Hypoplasia of the posterior mitral valve leaflet: Don’t forget to look beyond the mitral valve. Gabaldón-Pérez A, Marcos-Garcés V, Muñoz Gil J, Chorro Gascó FJ, Santas E. Echocardiography. 2021 Jan;38(1):142-143. doi: 10.1111/echo.14910. PMID: 33107084

Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients. Rumiz E, Cubillos A, Vilar J, Garcia P, Berenguer A, Facila L, Valero E, Vidal V, Morell S, Nunez J. Scientific Reports. 2021 Aug 16;11(1):16597. doi: 10.1038/s41598-021-95897-5. PMID: 34400680

Iron deficiency and short-term adverse events in patients with decompensated heart failure. Palau P, Llacer P, Dominguez E, Tormo J, Zakarne R, Mollar A, Martinez A, Minana G, Santas E, Almenar L, Facila L, de la Espriella R, Nunez E, Manzano L, Bayes-Genis A, Nunez J. Clinical Research in Cardiology. 2021 Aug;110(8):1292-1298. doi: 10.1007/s00392-021-01832-z. PMID: 33721056

Iron deficiency testing and treatment in heart failure: the eyes are useless when the mind is blind. Minana G, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2021 Nov;23(11):1855-1857. doi: 10.1002/ejhf.2365. PMID: 34655260

Is acute heart failure a distinctive disorder? An analysis from BIOSTAT-CHF. Davison B, Senger S, Sama I, Koch G, Mebazaa A, Dickstein K, Samani N, Metra M, Anker S, Cleland J, Ng L, Mordi I, Zannad F, Filippatos G, Hillege H, Ponikowski P, van Veldhuisen D, Lang C, van der Meer P, Nunez J, Bayes-Genis A, Edwards C, Voors A, Cotter G. European Journal of Heart Failure. 2021 Jan;23(1):43-57. doi: 10.1002/ejhf.2077. PMID: 33340221

Long-term outcome of patients with NSTEMI and nonobstructive coronary arteries by different angiographic subtypes. Garcia-Blas S, Gonzalez D’ Gregorio J, Bonanad C, Fernandez-Cisnal A, Valero E, Minana G, Mollar A, Nunez J, Sanchis J. Revista Espanola de Cardiologia. 2021 Nov;74(11):919-926. doi: 10.1016/j.rec.2020.10.008. PMID: 33349589

Long-term prognostic implications of revascularization in patients with known or suspected chronic coronary syndromes without ischemia in vasodilator stress cardiovascular magnetic resonance. Minana G, Nunez J, Marcos-Garces V, Gavara J, Rios-Navarro C, Bodi V. International Journal of Cardiology. 2021 Jul 15;335:15-18. doi: 10.1016/j.ijcard.2021.04.037. PMID: 33895211

Long-Term Prognostic Value of Cognitive Impairment on Top of Frailty in Older Adults after Acute Coronary Syndrome. Sanchis J, Bonanad C, Garcia-Blas S, Ruiz V, Fernandez-Cisnal A, Sastre C, Ruescas A, Valero E, Gonzalez J, Mollar A, Minana G, Nunez J. Journal of Clinical Medicine. 2021 Jan 24;10(3):444. doi: 10.3390/jcm10030444. PMID: 33498816

Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications. GAVARA DOÑATE J, Rodriguez-Palomares J, Rios Navarro C, Valente F, Monmeneu J, Lopez-Lereu M, Ferreira-Gonzalez I, Garcia Del Blanco B, Otaegui I, Canoves Femenia J, De Dios Lluch E, Pérez Solé N, Racugno P, Bonanad Lozano C, Miñana Escriva G, Marcos Garcés V, Barrabes J, Evangelista A, Moratal D, Bayes-Genis A, Nuñez Villota J, Chorro Gascó F, Bodí Peris V. The International Journal Of Cardiovascular Imaging. 2021 Jan;37(1):241-253. doi: 10.1007/s10554-020-01890-w. PMID: 32488452

Lung ultrasound in outpatients with heart failure: the wet-to-dry HF study. Domingo M, Lupon J, Girerd N, Conangla L, de Antonio M, Moliner P, Santiago-Vacas E, Codina P, Cediel G, Spitaleri G, Gonzalez B, Diaz V, Rivas C, Velayos P, Nunez J, Bayes-Genis A. ESC Heart Failure. 2021 Dec;8(6):4506-4516. doi: 10.1002/ehf2.13660. PMID: 34725962

Matrix metalloproteinase-12 cleaved fragment of titin as a predictor of functional capacity in patients with heart failure and preserved ejection fraction. Palau Sampio P, Reese-Petersen A, Dominguez E, Ramón Ferrandis J, Lopez L, Mollar Fernandez A, Chorro Gascó F, Sanchis Fores J, Nuñez Villota J. Scandinavian Cardiovascular Journal. 2021 Feb;55(1):9-14. doi: 10.1080/14017431.2020.1831052. PMID: 33030056

Mid-term Prognostic Implication of hospitalized COVID-19 patients with Prior Heart Failure diagnosis. Llacer P, Manzano L, Fernandez C, Moreno M, Nunez J. European Journal of Internal Medicine. 2021 Jun;88:136-138. doi: 10.1016/j.ejim.2021.02.013. PMID: 33676804

Mortality trends in an ambulatory multidisciplinary heart failure unit from 2001 to 2018. Spitaleri G, Lupon J, Domingo M, Santiago-Vacas E, Codina P, Zamora E, Cediel G, Santesmases J, Diez-Quevedo C, Troya M, Boldo M, Altmir S, Alonso N, Gonzalez B, Nunez J, Bayes-Genis A. Scientific reports. 2021 Jan 12;11(1):732. doi: 10.1038/s41598-020-79926-3. PMID: 33436787

Native mitral valve endocarditis complicated with abscess and fistulas: Diagnosis by three-dimensional transesophageal echocardiography. Gabaldon-Perez A, de la Espriella R, Merenciano-Gonzalez H, Santas E, Chorro F. Revista Portuguesa de Cardiologia. 2021 Aug 30:S0870-2551(21)00345-0. doi: 10.1016/j.repc.2020.06.023. PMID: 34474955

Potential Utility of Cardio-Renal Biomarkers For Prediction and Prognostication of Worsening Renal Function in Acute Heart Failure: Cardio-Renal Biomarkers and WRF in AHF. Horiuchi Y, Wettersten N, van Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, Barnett O, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, Murray P. Journal of Cardiac Failure. 2021 May;27(5):533-541. doi: 10.1016/j.cardfail.2020.11.025. PMID: 33296713

Predictive value of pro-BNP for heart failure readmission after an acute coronary syndrome. Cordero A, Rey-Ranal E, Moreno M, Escribano D, Moreno-Arribas J, Quintanilla M, Zuazola P, Nunez J, Bertomeu-Gonzalez V. Journal of Clinical Medicine. 2021 Apr 13;10(8):1653. doi: 10.3390/jcm10081653. PMID: 33924437

Prognosis impact of diabetes in elderly women and men with non-ST elevation acute coronary syndrome. Diez-Villanueva P, Garcia-Acuna JM, Raposeiras-Roubin S, Barrabes JA, Cordero A, Martinez-Selles M, Bardaji A, Marin F, Ruiz-Nodar JM, Vicente-Ibarra N, Alonso Salinas GL, Cid-Alvarez B, Abu Assi E, Formiga F, Nunez J, Nunez E, Ariza-Sole A, Sanchis J. Journal of Clinical Medicine. 2021 Sep 26;10(19):4403. doi: 10.3390/jcm10194403. PMID: 34640420

Prognostic value of indexed pulmonary artery diameter assessed by cardiac magnetic resonance imaging in patients with acute heart failure. Nuñez Villota J, Merenciano González H, Santas Olmeda E, Lopez Lereu M, Monmeneu Menadas J, Valero Picher E. Revista Espanola De Cardiologia (english Ed.). 2021 Mar;74(3):267-269. doi: 10.1016/j.rec.2020.06.039. PMID: 32978097

Quantification and treatment of congestion in heart failure: a clinical and pathophysiological overview. de la Espriella R, Santas E, Zegri Reiriz I, Gorriz J, Cobo Marcos M, Nunez J. Nefrologia. 2021 Jul 18:S0211-6995(21)00114-4. doi: 10.1016/j.nefro.2021.04.006. PMID: 34289940

Randomized Comparison of Exercise Intervention Versus Usual Care in Older Adult Patients with Frailty After Acute Myocardial Infarction. Sanchis J, Sastre C, Ruescas A, Ruiz V, Valero E, Bonanad C, Garcia-Blas S, Fernandez-Cisnal A, Gonzalez J, Minana G, Nunez J. American Journal of Medicine. 2021 Mar;134(3):383-390.e2. doi: 10.1016/j.amjmed.2020.09.019. PMID: 33228950

Rationale and design of the efficacy of a standardized diuretic protocol in acute heart failure study. Dauw J, Lelonek M, Zegri-Reiriz I, Paredes-Paucar C, Zara C, George V, Cobo-Marcos M, Knappe D, Shchekochikhin D, Lekhakul A, Klincheva M, Frea S, Miro O, Barker D, Borbely A, Nasr S, Doghmi N, de la Espriella R, Singh J, Bovolo V, Fialho I, Ross N, van den Heuvel M, Benkouar R, Findeisen H, Alhaddad I, Al Balbissi K, Barge-Caballero G, Ghazi A, Bruckers L, Martens P, Mullens W. ESC Heart Failure. 2021 Dec;8(6):4685-4692. doi: 10.1002/ehf2.13666. PMID: 34708555

Regulatory network analysis in estradiol-treated human endothelial cells. Perez-Cremades D, Paes A, Vidal-Gomez X, Mompeon A, Hermenegildo C, Novella S. International Journal of Molecular Sciences. 2021 Jul 30;22(15):8193. doi: 10.3390/ijms22158193. PMID: 34360960

Relation of Decongestion and Time to Diuretics to Biomarker Changes and Outcomes in Acute Heart Failure. Horiuchi Y, Wettersten N, van Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, Barnett O, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, Murray P. American Journal of Cardiology. 2021 May 15;147:70-79. doi: 10.1016/j.amjcard.2021.01.040. PMID: 33617811

Right heart dysfunction and readmission risk across left ventricular ejection fraction status in patients with acute heart failure. Santas E, Minana G, Palau P, De La Espriella R, Lorenzo M, Nunez G, Sanchis J, Chorro FJ, Bayes-Genis A, Nunez J. Journal of Cardiac Failure. 2021 Oct;27(10):1090-1098. doi: 10.1016/j.cardfail.2021.06.020. PMID: 34273477

Right ventricular function and iron deficiency in acute heart failure. Miñana Escriva G, Santas Olmeda E, De La Espriella Juan R, Nunez E, Lorenzo Hernández M, Núñez Marín G, Valero Picher E, Bodí Peris V, Chorro Gascó F, Sanchis Fores J, Cohen-Solal A, Bayes-Genis A, Nuñez Villota J. European heart journal. Acute cardiovascular care. 2021 May 25;10(4):406-414. doi: 10.1093/ehjacc/zuaa028. PMID: 33620455

Sex differences on new-onset heart failure in patients with known or suspected coronary artery disease. Nunez J, Lorenzo M, Minana G, Palau P, Monmeneu JV, Lopez-Lereu MP, Gavara J, Marcos-Garces V, Rios-Navarro C, Perez N, de Dios E, Nunez E, Sanchis J, Chorro FJ, Bayes-Genis A, Bodi V. European Journal of Preventive Cardiology. 2021 Dec 29;28(15):1711-1719. doi: 10.1093/eurjpc/zwab078. PMID: 33970216

Sotagliflozin in patients with diabetes and recent worsening heart failure. Bhatt D, Szarek M, Steg P, Cannon C, Leiter L, McGuire D, Lewis J, Riddle M, Voors A, Metra M, Lund L, Komajda M, Testani J, Wilcox C, Ponikowski P, Lopes R, Verma S, Lapuerta P, Pitt B, SOLOIST-WHF Trial Investigators. New England Journal of Medicine. 2021 Jan 14;384(2):117-128. doi: 10.1056/NEJMoa2030183. PMID: 33200892

sST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction. De La Espriella Juan R, Bayes-Genis A, Revuelta E, Miñana Escriva G, Santas Olmeda E, Llacer P, Garcia Blas S, Fernández Cisnal A, Bonanad Lozano C, Ventura S, Sanchez R, Bodí Peris V, Cordero A, Facila De La Esperanza R, Mollar Fernandez A, Sanchis Fores J, Improve-Hf Investigators, Nuñez Villota J. Journal Of Cardiac Failure. 2021 Apr;27(4):427-434. doi: 10.1016/j.cardfail.2020.10.002. PMID: 33038531

Students’ perceptions of instructional rubrics in neurological physical therapy and their effects on students’ engagement and course satisfaction. Garcia-Ros R, Ruescas-Nicolau M, Cezon-Serrano N, Carrasco J, Perez-Alenda S, Sastre-Arbona C, San Martin-Valenzuela C, Flor-Rufino C, Sanchez-Sanchez M. International Journal of Environmental Research and Public Health. 2021 May 6;18(9):4957. doi: 10.3390/ijerph18094957. PMID: 34066623

Supervised Analysis for Phenotype Identification: The Case of Heart Failure Ejection Fraction Class. Lopez C, Holgado JL, Cortes R, Sauri I, Fernandez A, Calderon JM, Nuñez J, Redon J. Bioengineering. 2021 Jun 21;8(6):85. doi: 10.3390/bioengineering8060085. PMID: 34205745

The ‘Peptide for Life’ Initiative: a call for action to provide equal access to the use of natriuretic peptides in the diagnosis of acute heart failure across Europe. Bayes-Genis A, Januzzi J, Richards A, Arfsten H, de Boer R, Emdin M, Gonzalez A, Jaarsma T, Jhund P, Mueller C, Nunez J, Rossignol P, Milinkovic I, Rosano G, Coats A, Seferovic P. European Journal of Heart Failure. 2021 Sep;23(9):1432-1436. doi: 10.1002/ejhf.2293. PMID: 34231321

The influence of sex and body mass index on the association between soluble neprilysin and risk of heart failure hospitalizations. Nunez J, Nunez E, Revuelta-Lopez E, Minana G, Barallat J, Bodi V, Sanchis J, Aimo A, Emdin M, Lupon J, Husser O, Bayes-Genis A. Scientific reports. 2021 Mar 15;11(1):5940. doi: 10.1038/s41598-021-85490-1. PMID: 33723360

The pre-HFpEF stage: a new entity that requires proper phenotyping for better management. Bayes-Genis A, Pascual-Figal D, Nuñez Villota J. European Journal of Preventive Cardiology. 2021 Aug 9;28(9):935-936. doi: 10.1177/2047487320902326. PMID: 32019372

Projects
Reference: PI22/00535
Title: Efectos de un programa de entrenamiento físico supervisado en pacientes con insuficiencia cardiaca y función sistólica preservada e incompetencia cronotrópica sobre capacidad funcional
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Patricia Palau Sampio
Duration: 2023 – 2025
Total budget: 44.770,00 €
Reference: PI22/01948
Title: Congestión como potencial catalizador de la progresión de la enfermedad renal crónica
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Rafael de la Espriella Juan, José Luis Górriz Teruel
Duration: 2023 – 2025
Total budget: 87.120,00 €
Reference: AICO/2021/129
Title: Efecto del bloqueo de la rama izquierda sobre capacidad funcional, disincronía electromecánica y función cardiaca en población general con patología cardiovascular
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Patricia Palau Sampio, Julio Núñez Villota
Duration: 2022 – 2024
Total budget: 90.000 €
Reference: PI21/01417
Title: Cribado sistemático de insuficiencia cardíaca en pacientes con diabetes mellitus tipo 2. Estudio piloto
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Enrique Santas Olmeda, Jorge Navarro Pérez
Duration: 2022 – 2024
Total budget: 90.871 €
Reference: SEC/FEC-INV-CLI 21/024
Title: Resonancia magnética cardíaca de estrés con vasodilatadores para predecir la mortalidad a largo plazo en un amplio registro retrospectivo de pacientes con cardiopatía isquémica conocida o sospechada
Funding body: Sociedad Española de Cardiología
Principal Investigator: Vicent Bodí Peris
Duration: 2021 – 2022
Total budget: 15.000 €
Reference: AP-2021-019
Title: HISTONATTR: Efecto de la activación de TLR por medio de sus ligandos sobre la polarización de macrófagos hacia M1 y su función citocida frente a las células madre de glioblastoma
Funding body: Universidad de Valencia – INCLIVA
Principal Investigator: Carlos Romá Mateo, Enrique Santas Olmeda
Duration: 2021 – 2022
Total budget: 4.750 €
Reference: PI20/00392
Title: Congestión renal e ninsuficiencia cardiaca aguda y síndroma cardiorenal: valoración no invasiva mediante doppler vascular renal
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Julio Núñez Villota
Duration: 2021 – 2023
Total budget: 94.834 €
Reference: PI17/01426
Title: Retirada del Tratamiento Betabloqueante en Pacientes con Insuficiencia Cardíaca con Función Sistólica Preservada e Incompetencia Cronotrópica. Efecto sobre la Capacidad Funcional
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Julio Núñez Villota
Duration: 2018 – 2021
Total budget: 127.050 €
Reference: PI17/01736
Title: Comparación aleatoria entre las estrategias invasivas y conservadoras en pacientes ancianos frágiles con infarto de miocardio sin elevación del segmento ST (MOSCA-FRAIL)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Gema Miñana Escrivá
Duration: 2018 – 2022
Total budget: 70.180 €
Reference: PIE15/00013
Title: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicente Bodí Peris
Duration: 2016 – 2019
Total budget: 589.050 €
+ Info
Comments on the 2019 ESC guidelines on diabetes, prediabetes, and cardiovascular disease. Joint Working Group of the SEC and SEEN for the 2019 ESC guidelines on diabetes, prediabetes, and cardiovascular diseases, Expert Reviewers for the 2019 ESC guidelines on diabetes, prediabetes, and cardiovascular diseases, and the SEC Guidelines Committee. Revista Espanola de Cardiologia (english Ed.). 2020 May;73(5):354-360. doi: 10.1016/j.rec.2019.11.018. PMID: 32205102

Title: Valor pronóstico de los parámetros de deformación miocárdica en una cohorte de pacientes con insuficiencia cardíaca crónica estable
Doctoral candidate: González D’ Gregorio, Jessika
Director(s): Nuñez Villota, Julio; Chorro Gascó, Francisco Javier
Date of the defense: 08/05/2023
University: Universitat de València

Title: Desarrollo de un algoritmo basado en técnicas de machine learning para estratificación de riesgo de pacientes con dolor torácico y primera determinación de troponina negativa
Doctoral candidate: Fernández Cisnal, Agustín
Director(s): Sanchis Forés, Juan; Núñez Villota, Julio
Date of the defense: 21/04/2023
University: Universitat de València

Title: Retirada del tratamiento betabloqueante en pacientes con insuficiencia cardíaca con función sistólica preservada e incompetencia cronotrópica. Efecto sobre la capacidad funcional
Doctoral candidate: Seller Moya, Julia
Director(s): Nuñez Villota, Julio; Palau Sampio, Patricia
Date of the defense: 25/01/2023
University: Universitat de València

Title: Historia clínica y niveles indetectables de troponina de alta sensibilidad en la evaluación del riesgo de pacientes con dolor torácico agudo y primera determinación de troponina normal.
Doctoral candidate: Valero Picher, Ernesto
Director(s): Sanchis Forés, Juan; Núñez Villota, Julio
Date of the defense: 28/01/2022
University: Universitat de València

Title: Beneficios físicos y psicológicos de la danza española en personas mayores
Doctoral candidate: Ibáñez Sanchis, Luis
Director(s): Igual Camacho, Celedonia; López Bueno, Laura
Date of the defense: 17/01/2022
University: Universitat de València

Title: Cambios en el contenido miocárdico de hierro tras la administración de hierro intravenoso (MYOCARDIAL-IRON)
Doctoral candidate: Cardells Beltrán, Ingrid
Director(s): Núñez Villota Julio; Miñana Escrivá, Gema
Date of the defense: 24/09/2021
University: Universitat de València

Title: Infarto agudo de miocardio sin elevación del segmento ST con coronarias sin lesiones angiográficas significativas: epidemiología, predictores e impacto pronóstico
Doctoral candidate: García Blas, Sergio
Director(s): Núñez Villota, Julio; Sanchis Fores, Juan
Date of the defense: 23/07/2020
University: Universitat de València