Research Group on Therapies Against Endometriosis and Endometrial Cancer
Reproductive Medicine Area
To refine the development of homologous and heterologous animal models initiated in the laboratory so that they allow to reproduce endometriosis in a more physiological way, reflecting the pain and infertility associated with it in order to achieve greater transferability of the findings in these to the clinic
On these optimized endometriosis animal models, evaluate whether immunomodulatory compounds, such as those currently marketed for clinical use in the non-hormonal treatment of osteoporosis, are effective in the remission of pain as well as in the improvement of fertility
To narrow down the molecular mechanisms involved in improving the parameters under study in order to refine therapeutic targets
To evaluate the clinical feasibility of early non-invasive diagnosis of endometriosis through the combined analysis of multiple biomarkers
Coordinator
STAFF
Collaborating Researchers
Lesley Escrivá Ardid
Nurse
Technicians
Carles Antúnez Muñoz
Administrative assistant
Publications
Histological grade and tumor stage are correlated with expression of receptor activator of nuclear factor Kappa b (Rank) in epithelial ovarian cancers. Gomez R, Tejada M, Rodriguez-Garcia V, Burgues O, Santos-Llamas A, Martinez-Massa A, Marin-Montes A, Tarin J, Cano A. International Journal of Molecular Sciences. 2022 Feb 3;23(3):1742. doi: 10.3390/ijms23031742. PMID: 35163671
Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain. Tejada MA, Santos Llamas A, Escriva L, Tarin JJ, Cano A, Fernandez Ramirez MJ, Nunez Badinez P, De Leo B, Saunders PTK, Vidal V, Barthas F, Vincent K, Sweeney PJ, Sillito RR, Armstrong JD, Nagel J, Gomez R. Biomedicines. 2022 Feb 21;10(2):501. doi: 10.3390/biomedicines10020501. PMID: 35203710
Bazedoxifene increases the proliferation of human arterial endothelial cells but does not affect the expression of cyclins A, B, and D1 and of p27(Kip1). Dudenko D, Gomez R, Garcia-Perez M, Tarin J, Cano A. Gynecological Endocrinology. 2021 Mar;37(3):269-272. doi: 10.1080/09513590.2021.1876653. PMID: 33480311
Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain. Nunez-Badinez P, De Leo B, Laux-Biehlmann A, Hoffmann A, Zollner T, Saunders P, Simitsidellis I, Charrua A, Cruz F, Gomez R, Tejada M, McMahon S, Lo Re L, Barthas F, Vincent K, Birch J, Meijlink J, Hummelshoj L, Sweeney P, Armstrong J, Treede R, Nagel J. Pain. 2021 Sep 1;162(9):2349-2365. doi: 10.1097/j.pain.0000000000002248. PMID: 34448751
Sigma-1 receptor: a drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain. Ruiz-Cantero M, Gonzalez-Cano R, Tejada M, Santos-Caballero M, Perazzoli G, Nieto F, Cobos E. Pharmacological Research. 2021 Jan;163:105339. doi: 10.1016/j.phrs.2020.105339. PMID: 33276102
Tetrodotoxin, a potential drug for neuropathic and cancer pain relief?. Gonzalez-Cano R, Ruiz-Cantero M, Santos-Caballero M, Gomez-Navas C, Tejada M, Nieto F. Toxins. 2021 Jul 12;13(7):483. doi: 10.3390/toxins13070483. PMID: 34357955
Cumulative probabilities of live birth across multiple complete IVF/ICSI cycles: a call for attention. Tarin Folgado J, Pascual E, Perez-Hoyos S, Gómez Gallego R, García Pérez M, Cano Sanchez A. Journal of Assisted Reproduction and Genetics. 2020 Jan;37(1):141-148. doi: 10.1007/s10815-019-01608-5. PMID: 31808046
Differential expression of Receptor Activator of Nuclear Factor Kappa B in healthy endometrium, ovarian endometrioma and endometrioid ovarian cancer. Gregori Romero M, Rodriguez Garcia V, Burgues Gasion O, Martinez Carmona J, Tarin Folgado J, Cano Sanchez A, Gómez Gallego R. American Journal of Obstetrics and Gynecology. 2020 Mar;222(3):279-281. doi: 10.1016/j.ajog.2019.11.1259. PMID: 31765641
Predictors of live birth in women with a history of biochemical pregnancies after assisted reproduction treatment. Tarin Folgado J, Pascual Castello E, Gómez Gallego R, García Pérez M, Cano Sanchez A. European journal of obstetrics, gynecology, and reproductive biology. 2020 May;248:198-203. PMID: 32240893
Projects
Title: Evaluación del potencial papel terapéutico de la inhibición de RANK en modelos optimizados de dolor e infertilidad asociados a endometriosis
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Raúl Gómez Gallego
Duration: 2021 – 2023
Total budget: 98.010 €
Title: Diagnóstico precoz no invasivo de endometriosis mediante análisis de nuevos biomarcadores a través de machine learning
Funding body: Fundación para la Innovación y Prospectiva en Salud en España (FIPSE)
Principal Investigator: Raúl Gómez Gallego
Duration: 2020 – 2020
Total budget: 30.000 €
Title: Papel de los agonistas dopaminergicos en el dolor e infertilidad asociados a endometriosis en modelos animales de nueva generación
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Raúl Gómez Gallego
Duration: 2018 – 2021
Total budget: 111.320 €
Title: Improving the care of patients suffering from acute or chronic pain
Funding body: European Commission
Principal Investigator: Raúl Gómez Gallego
Duration: 2018 – 2023
Total budget: 257.066 €
+ Info
Doctoral candidate: Dudenko Lozenko, Darya
Director(s): Cano Sánchez, Antonio; Tarín Folgado, Juan José; Gómez Gallego, Raúl
Date of the defense: 30/06/2020
University: Universitat de València
Title: Evaluación estandarizada del potencial antiangiógénico del agonista dopaminérgico en el tratamiento de la endometriosis
Doctoral candidate: Blanca Ruiz, Taqua
Director(s): Cano Sánchez, Antonio; Gómez Gallego, Raúl
Date of the defense: 17/01/2019
University: Universitat de València