Research Group on General and Digestive Surgery
Metabolism and Organic Damage Area
This Group is a large research group that is working on various aspects of General and Digestive Surgery. Formed by different Units (Colorrectal, HBP, Esophagogastric, Endocrine-Metabolic, Breast, Abdominal Wall surgeries), all of them very active, they develop different lines of research, in accordance with the objectives of each Unit, which annually give rise to multiple publications, many of them multicenter, focused mainly on oncological, endocrine-metabolic and management aspects of processes.

Coordinator
RESEARCHERS
Established, R3
Alejandro Espí MacíasLuis Sabater Ortí
Recognised/Emerging, R2
David Casado RodrigoDavid Moro ValdezateDimitri DorcarattoElena Muñoz FornerEstefanía García BotelloFernando López MozosJosé Martín ArévaloMarina Garcés AlbirNorberto Cassinello FernándezRaquel Alfonso BallesterRoberto Martí ObiolVicente Pla Martí
First Stage, R1
Carlos León EspinozaIsabel Mora OliverLeticia Pérez SantiagoMª Carmen Fernández MorenoMaría Lapeña Rodríguez
STAFF
Collaborating Researchers
Elena Martí CuñatGuillermo Pou SantonjaMª Eugenia Barrios CarvajalMarcos Adrianzén VargasRosa Martí FernándezVicente López Flor
Nurse
Technicians
Administrative assistant
Publications
CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction. Hueso L, Marques P, Morant B, Gonzalez-Navarro H, Ortega J, Real J, Sanz M, Piqueras L. Frontiers in Endocrinology. 2023 Apr 12;14:1154158. doi: 10.3389/fendo.2023.1154158. PMID: 37124725
Clinical and cost outcomes of a polyethylene glycol (PEG)-coated patch versus drainage after axillary lymph node dissection in breast cancer: results from a multicentre randomized clinical trial. Buch-Villa E, Castaner-Puga C, Delgado-Garcia S, Fuster-Diana C, Vidal-Herrador B, Ripoll-Orts F, Galeote-Quecedo T, Prat A, Andres-Matias M, Jimeno-Fraile J, Munoz-Sorsona E, Vento G, Gumbau-Puchol V, Adrianzen M, Lopez-Flor V, Ortega J. British Journal of Surgery. 2023 Jun 14;znad150. doi: 10.1093/bjs/znad150. PMID: 37311694
Clinical decisions in pancreatic cancer surgery: a national survey and case-vignette study. Ramia J, Cugat E, De la Plaza R, Gomez-Bravo M, Martin E, Munoz-Bellvis L, Padillo F, Sabater L, Serradilla-Martin M. Updates in Surgery. 2023 Jan;75(1):115-131. doi: 10.1007/s13304-022-01415-1. PMID: 36376560
Correction: Evolving trends in the management of acute appendicitis during COVID-19 waves: the ACIE Appy II Study (vol 46, pg 2021, 2022). Pata F, Di Martino M, Podda M, Di Saverio S, Ielpo B, Pellino G. World Journal of Surgery. 2023 Jan;47(1):285. doi: 10.1007/s00268-022-06808-2. PMID: 36273052
ASO visual abstract: long-term outcomes of perioperative versus neoadjuvant chemotherapy for resectable colorectal liver metastases-an international multicenter propensity-score matched analysis with stratification by contemporary risk scoring. Di Martino M, Primavesi F, Syn N, Dorcaratto D, de la Hoz Rodriguez A, Dupre A, Piardi T, Rhaiem R, Blanco Fernandez G, de Armas Conde N, Rodriguez Sanjuan J, Fernandez Santiago R, Fernandez-Moreno M, Ferret G, Lopez Ben S, Suarez Munoz M, Perez-Alonso A, Koh Y, Jones R, Martin-Perez E. Annals of Surgical Oncology. 2022 Oct;29(11):6845-6846. doi: 10.1245/s10434-022-12077-z. PMID: 35810229
Concordance and survival implications of preoperative subclassification of T3 rectal cancers by depth of mesorectal invasion using a 5-mm cut-off point with endorectal ultrasound and magnetic resonance imaging. Botello S, Fernandez R, Lozano C, Salher S, Arevalo J, Valdezate D, Marti V, Macias A. Quantitative Imaging in Medicine and Surgery. 2022 Apr;12(4):2356-2367. doi: 10.21037/qims-21-880. PMID: 35371947
Dr. Luis Aparisi Quereda In memoriam. Sabater L, Sastre J, de Madaria E. Gastroenterologia y Hepatologia. 2022 Oct 12:S0210-5705(22)00218-7. doi: 10.1016/j.gastrohep.2022.08.011. PMID: 36243628
Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. NIHR Global Health Unit on Global Surgery; COVIDSurg Collaborative. Lancet. 2022 Nov 5;400(10363):1607-1617. doi: 10.1016/S0140-6736(22)01846-3. PMID: 36328042
Botulinum toxin injection plus topical diltiazem for chronic anal fissure: a randomized double-blind clinical trial and long-term outcome. Herreros B, Espi A, Monton Rodriguez C, Garcia-Granero E, Sanchiz V, Ferriols FL, Almela P, Hernandez V, Mora F, Minguez M. Diseases of the Colon and Rectum. 2021 Dec 1;64(12):1521-1530. doi: 10.1097/DCR.0000000000001983. PMID: 34747917
Circulating Tumor DNA Detection by Digital-Droplet PCR in Pancreatic Ductal Adenocarcinoma: A Systematic Review. Huerta M, Rosello S, Sabater L, Ferrer A, Tarazona N, Roda D, Gambardella V, Alfaro-Cervello C, Garces-Albir M, Cervantes A, Ibarrola-Villava M. Cancers. 2021 Feb 27;13(5):994. doi: 10.3390/cancers13050994. PMID: 33673558
Clinical symptoms are correlated with gastrojejunal anastomosis complications only during the first year after laparoscopic Roux-en-Y gastric bypass. Lapena Rodriguez M, Cassinello Fernandez N, Martin Arevalo J, Sanchiz Soler V, Alfonso Ballester R, Ortega Serrano J. Nutricion Hospitalaria. 2021 Oct 13;38(5):978-982. doi: 10.20960/nh.03602. PMID: 34036791
Corrigendum to Corrigendum to Hydroxyethyl starch and acute kidney injury in high-risk patients undergoing cardiac surgery: A prospective multicenter study [J Clin Anesth 2021 Oct;73:110367]. Nagore D, Candela A, Burge M, Monedero P, Tamayo E, Alvarez J, Murie M, Wijeysundera DN, Vives M, Vives M, Mendez E, Pasqualetto A, Mon T, Pita R, Varela MA, Esteva C, Pereira MA, Sanchez J, Rodriguez MA, Garcia A, Carmona P, Lopez M, Pajares A, Vicente R, Aparicio R, Gragera I, Calderon E, Candela A, Marcos JM, Gomez L, Rodriguez JM, Matilla A, Medina A, Morales L, Santana L, Garcia E, Monedero P, Montesinos S, Munoz P, Bravo B, Alvarez J, Blanco V. Journal of Clinical Anesthesia. 2021 Dec;75:110436. doi: 10.1016/j.jclinane.2021.110436. PMID: 34509966
Analysis of mid-term weight loss after Roux-en-Y gastric bypass and sleeve gastrectomy: Proposed percentile charts for total weight loss percentages to be used in daily clinical practice. Sabench Pereferrer F, Molina Lopez A, Acin Gandara D, Arroyo Martin J, Baltar Boileve J, Barranco Moreno A, Cassinello Fernández N, del Castillo Dejardin D, Fernandez Alsina E, Ferrer-Marquez M, Mans Muntwyler E, Martin Garcia-Almenta E, Ruiz de Gordejuela A. Cirugia Espanola. 2020 Feb;98(2):72-78. doi: 10.1016/j.ciresp.2019.09.008. PMID: 31757409
Delaying surgery for patients with a previous SARS-CoV-2 infection. COVIDSurg Collaborative. British Journal of Surgery. 2020 Nov;107(12):e601-e602. doi: 10.1002/bjs.12050. PMID: 32974904
Detection of postoperative plasma circulating tumour DNA and lack of CDX2 expression as markers of recurrence in patients with localised colon cancer. Tarazona Llavero N, Gimeno Valiente F, Gambardella V, Huerta Alvaro M, Roselló Keränen S, Zúñiga Trejos S, Calon A, Carbonell Asins J, Fontana E, Martínez Ciarpaglini M, Eason K, Rentero Garrido P, Fleitas Kanonnikoff T, Papaccio F, Moro Valdezate D, Nyamundanda G, Castillo Aliaga J, Espí Macias A, Sadanandam A, Roda Perez D, Cervantes Ruiperez A. ESMO Open. 2020 Sep;5(5):e000847. doi: 10.1136/esmoopen-2020-000847. PMID: 32967918
Distal pancreatectomy with multivisceral resection: A retrospective multicenter study – Case series. Ramia J, del Rio-Martin J, Blanco-Fernandez G, Cantalejo-Diaz M, Rotellar-Sastre F, Sabater Orti L, Carabias-Hernandez A, Manuel-Vazquez A, Hernandez-Rivera P, Jaen-Torrejimeno I, Kalviainen-Mejia H, Esteban-Gordillo S, Muñoz Forner E, De La Plaza R, Longoria-Dubocq T, De Armas-Conde N, Pardo-Sanchez F, Garces Albir M, Serradilla-Martin M. International Journal of Surgery. 2020 Oct;82:123-129. doi: 10.1016/j.ijsu.2020.08.024. PMID: 32860956
Projects
Title: Transección Pancreática asistida por Radiofrecuencia vs Endograpadora. TRANSPAIRE. Ensayo clínico en fase III
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Patricia Sánchez Velázquez
Duration: 2021 – 2023
Total budget: 75.020 €
Title: Anastomosis pancreática tras duodenopancreatect omía cefálica: pancreatogastrostomia versus anastomosis de blumgart. estudio prospectivo, aleatorizado y multicéntrico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Luis Sabater Ortí
Duration: 2020 – 2023
Total budget: 85.910 €
Title: Impacto de la diseminación de las CTCs durante la duodenopancreatectomía cefálica en la aparición de metástasis y supervivencia en pacientes con tumores de páncreas y periampulares
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Javier Padillo
Duration: 2017 – 2019
Total budget: 80.465 €
Title: Duodenopancreatectomía cefálica en tumores de páncreas y periampulares: abordaje inicial de la arteria mesentérica superior versus abordaje clásico. Estudio prospectivo, aleatorizado y multicéntrico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Luis Sabater Ortí
Duration: 2016 – 2019
Total budget: 56.265 €
+ Info
Doctoral candidate: García Fadrique, Alfonso Luis
Director(s): Sabater Ortí, Luis; Estevan Estevan, Rafael; Escrig Sos, Javier
Date of the defense: 18/12/2020
University: Universitat de València