Research Group on Exercise, Nutrition and Healthy Lifestyle

Metabolism and Organic Damage Area

Role of nicotinamide riboside (NR) and Urolithin A (UroA) as mitotherapeutics for the reversal of energy collapse associated with aging

Role of β-hydroxybutyrate on the loss of muscle mass associated with aging

Effect of an intervention with protein and vitamin supplementation in synergy with a multicomponent program of physical exercise in the reversal of frailty

Effect of glucosamine supplementation on physical performance

Evaluation of the neuroprotective effect of ketogenic diets (intermittent fasting and carbohydrate-free diet)

High intensity interval exercise in the prevention and treatment of frailty

Study of the effect of the activation of glucose 6 phosphate dehydrogenase with different intervention strategies in the prevention of frailty

Dra. Mª Carmen Gómez Cabrera
Coordinator
Dra. Mª Carmen Gómez Cabrera
carmen.gomez@uv.es

RESEARCHERS
Leading, R4
Established, R3

Mª Carmen Gómez Cabrera    
Juan Gambini Buchón

Recognised/Emerging, R2

Aitor Carretero Martínez
Esther García Domínguez
Fernando Millán Domingo
Gloria Olaso González

First Stage, R1

Abril Gorgori González
Ángela García Correas
Eva Tamayo Torres
Kristine Stromsnes
Silvana Javiera Soto Rodríguez

STAFF
Collaborating Researchers

Remus Iulian Lupu

Nurse
Technicians
Administrative assistant
Publications
Low muscle mass is associated with poorer glycemic control and higher oxidative stress in older patients with type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez-Hervas S, Gomez-Cabrera M, Real J. Nutrients. 2023 Jul 17;15(14):3167. doi: 10.3390/nu15143167. PMID: 37513585

Oxidative stress, atherogenic dyslipidemia, and cardiovascular risk. Vekic J, Stromsnes K, Mazzalai S, Zeljkovic A, Rizzo M, Gambini J. Biomedicines. 2023 Oct 26;11(11):2897. doi: 10.3390/biomedicines11112897. PMID: 38001900

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models. Costa-Machado L, Garcia-Dominguez E, McIntyre R, Lopez-Aceituno J, Ballesteros-Gonzalez A, Tapia-Gonzalez A, Fabregat-Safont D, Eisenberg T, Gomez J, Plaza A, Sierra-Ramirez A, Perez M, Villanueva-Bermejo D, Fornari T, Loza M, Herradon G, Hofer S, Magnes C, Madeo F, Duerr J, Pozo O, Galindo M, Del Pino I, Houtkooper R, Megias D, Vina J, Gomez-Cabrera M, Fernandez-Marcos P. Nature Communications. 2023 May 15;14(1):2779. doi: 10.1038/s41467-023-38410-y. PMID: 37188705

Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice. Rodriguez-Ramiro I, Pastor-Fernández A, López-Aceituno JL, Garcia-Dominguez E, Sierra-Ramirez A, Valverde AM, Martinez-Pastor B, Efeyan A, Gomez-Cabrera MC, Viña J, Fernandez-Marcos PJ. Free Radical Biology & Medicine. 2023 Nov 29:210:448-461. doi: 10.1016/j.freeradbiomed.2023.11.019. PMID: 38036067

Pomegranate extract administration reverses loss of motor coordination and prevents oxidative stress in cerebellum of aging mice. Verdú D, Valls A, Díaz A, Carretero A, Dromant M, Kuligowski J, Serna E, Viña J. Antioxidants. 2023 Nov 11;12(11):1991. doi: 10.3390/antiox12111991. PMID: 38001844

Residual effects of 12 weeks of power-oriented resistance training plus high-intensity interval training on muscle dysfunction, systemic oxidative damage, and antioxidant capacity after 10 months of training cessation in older people with COPD. Baltasar-Fernandez I, Losa-Reyna J, Carretero A, Rodriguez-Lopez C, Alfaro-Acha A, Guadalupe-Grau A, Ara I, Alegre L, Gomez-Cabrera M, Garcia-Garcia F, Alcazar J. Scandinavian Journal of Medicine & Science in Sports. 2023 Sep;33(9):1661-1676. doi: 10.1111/sms.14428. PMID: 37322570

Allopurinol blocks aortic aneurysm in a mouse model of Marfan syndrome via reducing aortic oxidative stress. Rodriguez-Rovira I, Arce C, De Rycke K, Perez B, Carretero A, Arbones M, Teixido-Tura G, Gomez-Cabrera M, Campuzano V, Jimenez-Altayo F, Egea G. Free Radical Biology & Medicine. 2022 Nov 5;193(Pt 2):538-550. doi: 10.1016/j.freeradbiomed.2022.11.00. PMID: 36347404

Exercise training as a modulator of epigenetic events in prostate tumors. Dufresne S, Gueritat J, Wong CP, Isanejad A, Ho E, Serna E, Gomez-Cabrera MC, Rebillard A. Prostate Cancer and Prostatic Diseases. 2022 Mar;25(1):119-122. doi: 10.1038/s41391-021-00380-x. PMID: 34007020

Glucosamine supplementation improves physical performance in trained mice. De la Rosa A, Olaso-Gonzalez G, Garcia-Dominguez E, Mastaloudis A, Hester S, Wood S, Gomez-Cabrera M, Vina J. Medicine and Science in Sports and Exercise. 2022 Mar 1;54(3):466-474. doi: 10.1249/MSS.0000000000002821. PMID: 34711707

Glucose 6-P dehydrogenase-an antioxidant enzyme with regulatory functions in skeletal muscle during exercise. Garcia-Dominguez E, Carretero A, Vina-Almunia A, Domenech-Fernandez J, Olaso-Gonzalez G, Vina J, Gomez-Cabrera MC. Cells. 2022 Sep 28;11(19):3041. doi: 10.3390/cells11193041. PMID: 36231003

Impact of supplementation with vitamins B6, B12, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: a systematic review. Olaso-Gonzalez G, Inzitari M, Bellelli G, Morandi A, Barcons N, Vina J. IUBMB Life. 2022 Jan;74(1):74-84. doi: 10.1002/iub.2507. PMID: 34058062

Multimodal strategy to rescue the brain in mild cognitive impairment: ketogenic oral nutrition supplementation with B vitamins and aerobic exercise. Cunnane SC, Swerdlow RH, Inzitari M, Olaso-Gonzalez G, Vina J. European Journal of Clinical Investigation. 2022 Sep;52(9):e13806. doi: 10.1111/eci.13806. PMID: 35488743

Real-life outcomes of a multicomponent exercise intervention in community-dwelling frail older adults and its association with nutritional-related factors. Millan-Domingo F, Tarazona-Santabalbina F, Carretero A, Olaso-Gonzalez G, Vina J, Gomez-Cabrera M. Nutrients. 2022 Dec 3;14(23):5147. doi: 10.3390/nu14235147. PMID: 36501177

The radiographic assessment of lung edema score of lung edema severity correlates with inflammatory parameters in patients with coronavirus disease 2019-Potential new admission biomarkers to predict coronavirus disease 2019 worsening. Marques P, Fernandez-Presa L, Carretero A, Gómez-Cabrera MC, Viña J, Signes-Costa J, Sanz MJ. Frontiers in Medicine. 2022 Aug 11;9:871714. doi: 10.3389/fmed.2022.871714. PMID: 36035415

Transcriptomic profile of epileptic children treated with ketogenic therapies. Ruiz-Herrero J, Olaso-Gonzalez G, Serna E, Canedo-Villarroya E, Correas A, Gambini J, Gomez-Cabrera M, Pedron-Giner C, Vina J. Journal of Integrative Neuroscience. 2022 Jan 28;21(1):31. doi: 10.31083/j.jin2101031. PMID: 35164467

A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts. Gomez-Cabrero D, Walter S, Abugessaisa I, Minambres-Herraiz R, Palomares L, Butcher L, Erusalimsky J, Garcia-Garcia F, Carnicero J, Hardman T, Mischak H, Zurbig P, Hackl M, Grillari J, Fiorillo E, Cucca F, Cesari M, Carrie I, Colpo M, Bandinelli S, Feart C, Peres K, Dartigues J, Helmer C, Vina J, Olaso G, Garcia-Palmero I, Martinez J, Jansen-Durr P, Grune T, Weber D, Lippi G, Bonaguri C, Sinclair A, Tegner J, Rodriguez-Manas L. GeroScience. 2021 Jun;43(3):1317-1329. doi: 10.1007/s11357-021-00334-0. PMID: 33599920

Activation of the constitutive androstane receptor inhibits leukocyte adhesiveness to dysfunctional endothelium. Lopez-Riera M, Ortega R, Hueso L, Montesinos MC, Gomez-Cabrera MC, Sanz MJ, Real JT, Piqueras L. International Journal of Molecular Sciences. 2021 Aug 27;22(17):9267. doi: 10.3390/ijms22179267. PMID: 34502180

Anti-inflammatory properties of diet: role in healthy aging.Stromsnes K, Correas A, Lehmann J, Gambini J, Olaso-Gonzalez G. Biomedicines. 2021 Jul 30;9(8):922. doi: 10.3390/biomedicines9080922. PMID: 34440125

Exploring potential benefits of accumulated multicomponent-training in non-active older adults: from physical fitness to mental health. Monteagudo P, Cordellat A, Roldan A, Gomez-Cabrera M, Pesce C, Blasco-Lafarga C. International Journal of Environmental Research and Public Health. 2021 Sep 13;18(18):9645. doi: 10.3390/ijerph18189645. PMID: 34574570

Frailty is associated with oxidative stress in older patients with Type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez-Hervas S, Gomez-Cabrera MC, Real JT. Nutrients. 2021 Nov 9;13(11):3983. doi: 10.3390/nu13113983. PMID: 34836238

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage. Arc-Chagnaud C, Salvador-Pascual A, Garcia-Dominguez E, Olaso-Gonzalez G, Correas A, Serna E, Brioche T, Chopard A, Fernandez-Marcos P, Serrano M, Serrano A, Munoz-Canoves P, Sebastia V, Vina J, Carmen Gomez-Cabrera M. Journal of Cachexia Sarcopenia and Muscle. 2021 Dec;12(6):1879-1896. doi: 10.1002/jcsm.12792. PMID: 34704386

Impact of COVID-19 Confinement on Physical Activity and Sedentary Behaviour in Spanish University Students: Role of Gender. Rodriguez-Larrad A, Manas A, Labayen I, Gonzalez-Gross M, Espin A, Aznar S, Serrano-Sanchez J, Vera-Garcia F, Gonzalez-Lamuno D, Ara I, Carrasco-Paez L, Castro-Pinero J, Gomez-Cabrera M, Marquez S, Tur J, Gusi N, Benito P, Moliner-Urdiales D, Ruiz J, Ortega F, Jimenez-Pavon D, Casajus J, Irazusta J. International Journal of Environmental Research and Public Health. 2021 Jan 6;18(2):369. doi: 10.3390/ijerph18020369. PMID: 33418907

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers. Garcia-Gimenez J, Mena-Molla S, Tarazona-Santabalbina F, Vina J, Gomez-Cabrera M, Pallardo F. International Journal of Environmental Research and Public Health. 2021 Feb 15;18(4):1883. doi: 10.3390/ijerph18041883. PMID: 33672064

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction. Roman W, Pinheiro H, Pimentel M, Segales J, Oliveira L, Garcia-Dominguez E, Gomez-Cabrera M, Serrano A, Gomes E, Munoz-Canoves P. Science. 2021 Oct 15;374(6565):355-359. doi: 10.1126/science.abe5620. PMID: 34648328

Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life. De la Rosa A, Gomez-Cabrera M, Vinue A, Gonzalez-Navarro H, Sanchez-Andres J, Vina J. Free radical biology & medicine. 2021 Feb 20;164:149-153. doi: 10.1016/j.freeradbiomed.2020.12.439. PMID: 33418115

Pharmacological properties of polyphenols: bioavailability, mechanisms of action, and biological effects in in vitro studies, animal models, and humans. Stromsnes K, Lagzdina R, Olaso-Gonzalez G, Gimeno-Mallench L, Gambini J. Biomedicines. 2021 Aug 23;9(8):1074. doi: 10.3390/biomedicines9081074. PMID: 34440278

Redox-related biomarkers in physical exercise. Gomez-Cabrera C, Carretero A, Millan-Domingo F, Garcia-Dominguez E, Correas AG, Olaso-Gonzalez G, Vina J. Redox Biology. 2021 Jun;42:101956. doi: 10.1016/j.redox.2021.101956. PMID: 33811000

Projects
Reference: 45/UPB/20
Title: Redes de Investigación en ciencias del deporte: EXERNET. Red de ejercicio físico y salud
Funding body: Ministerio de Cultura y Deportes
Principal Investigator: José Antonio Casajús
Duration: 2021 – 2022
Total budget: 8.000 €
Reference: PROMETEO/2019/097
Title: Diferencias de fragilidad entre generos: Evaluación de biomarcadores y estrategias de intervención
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: José Viña Ribes
Duration: 2020 – 2023
Total budget: 189.391 €
Reference: 0551_PSL_6_E
Title: Ejercicio físico personalizado como intervención para revertir la discapacidad en adultos mayores que viven en residencias (RESIFIT)
Funding body: Fundación General del Consejo Superior de Investigaciones Científicas (FGCSIC)
Principal Investigator: Mª Carmen Gómez Cabrera
Duration: 2020 – 2021
Total budget: 24.000 €
Reference: PID2019-110906RB-100
Title: Nuevas intervenciones terapéuticas multidominio para retrasar la fragilidad y la discapacidad. Identificación de mecanismos moleculares con relevancia traslacional (Mitofrail)
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: José Viña Ribes, Mª Carmen Gómez Cabrera
Duration: 2020 – 2023
Total budget: 270.000 €
Reference: 825546-DIABFRAIL-LATAM-
Title: Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmerica
Funding body: European Commission
Principal Investigator: José Viña Ribes
Duration: 2019 – 2024
Total budget: 273.720 €
+ Info
Company: EpiDisease
Starting year: 2014
Researchers: García Giménez, José Luis
Web: http://www.epidisease.com/

Title: Modulación del balance redox como estrategia para un envejecimiento saludable
Doctoral candidate: García Domínguez, Esther
Director(s): Viña Ribes, José; Gómez Cabrera, Mari Carmen; Blasco Lafarga, Cristina
Date of the defense: 01/01/2023
University: University de Valencia

Title: Intervención con ejercicio físico multicomponente sobre el adulto mayor frágil en la vida real (Real Life Intervention)
Doctoral candidate: Millán Domingo, Fernando
Director(s): Viña Ribes, José; Gómez Cabrera, María Carmen; Tarazona Santabalbina, Francisco José
Date of the defense: 01/07/2022
University: Universitat de València

Title: Papel de la xantina oxidasa en la pérdida de masa muscular por inmovilización en humanos. Importancia del protocolo de obtención de biopsias musculares en los estudios de atrofia muscular
Doctoral candidate: Sebastiá Alcàcer, Vicente
Director(s): Gómez Cabrera, Mª Carmen; Viña Ribes, José; Viosca Herrero, Enrique
Date of the defense: 28/06/2022
University: Universitat de València

Title: Impacto del ejercicio físico a largo plazo en la neuroprotección de sujetos de mediana edad: estudio de los mecanismos moleculares involucrados
Doctoral candidate: De La Rosa González, Adrián
Director(s): Gómez Cabrera, M. Carmen; Sanfeliú Pujol, Coral; Viña Ribes, José
Date of the defense: 05/06/2020
University: Universitat de València

Title: Regulation of antioxidant defenses in the prevention of skeletal muscle deconditioning
Doctoral candidate: Arc-Chagnaud, Coralie
Director(s): Viña Ribes, José; Gómez-Cabrera, Carmen; Chopard, Angèle; Brioche, Thomas
Date of the defense: 22/11/2019
University: Universitat de València

Title: Moderate overexpression of glucose-6-phosphate dehydrogenase improves healthspan in mice. Implications in skeletal muscle regeneration
Doctoral candidate: Salvador Pascual, Andrea
Director(s): Viña Ribes, José; Gomez Cabrera, M. Carmen
Date of the defense: 15/07/2019
University: Universitat de València