Research Group on Epigenomics and Translational Epigenetics

Metabolism and Organic Damage Area

Deepen the characterization of the epigenetic mechanisms that give phenotypic variability in human diseases, and that can give rise to diagnostic and prognostic biomarkers that can be implemented in precision medicine:

– Identification of epigenetic mechanisms and biomarkers in Rare Diseases

– Identification of epigenetic biomarkers in sepsis and neonatal sepsis

– Comprehension of the mechanisms mediating the heterogeneity and complexity of sepsis by generating new organoid models

Dr. Jose Luis García Giménez
Coordinator
Dr. Jose Luis García Giménez
j.luis.garcia@uv.es

RESEARCHERS
Leading, R4
Established, R3

José Ferreres Franco
Salvador Mena Mollá
Nieves Carbonell Monleón
Jose Luis García Giménez    

Recognised/Emerging, R2
First Stage, R1

Elena Nacher Sendra
Rebeca Osca Verdegal

STAFF
Collaborating Researchers
Nurse
Technicians

Laura Romero Jaque

Administrative assistant
Publications
Age-Related microRNA overexpression in Lafora disease male mice provides links between neuroinflammation and oxidative stress. Roma-Mateo C, Lorente-Pozo S, Marquez-Thibaut L, Moreno-Estelles M, Garces C, Gonzalez D, Lahuerta M, Aguado C, Garcia-Gimenez JL, Sanz P, Pallardo FV. International Journal of Molecular Sciences. 2023 Jan 6;24(2):1089. doi: 10.3390/ijms24021089. PMID: 36674605

Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis. Riera J, Barbeta E, Tormos A, Mellado-Artigas R, Ceccato A, Motos A, Fernandez-Barat L, Ferrer R, Garcia-Gasulla D, Penuelas O, Lorente J, Menendez R, Roca O, Palomeque A, Ferrando C, Sole-Violan J, Novo M, Boado M, Tamayo L, Estella A, Galban C, Trenado J, Huerta A, Loza A, Aguilera L, Garmendia J, Barbera C, Gumucio V, Socias L, Franco N, Valdivia L, Vidal P, Sagredo V, Ruiz-Garcia A, Varela I, Lopez J, Pozo J, Nieto M, Gomez J, Blandino A, Valledor M, Bustamante-Munguira E, Sanchez-Miralles A, Penasco Y, Barberan J, Ubeda A, Amaya-Villar R, Martin M, Jorge R, Caballero J, Marin J, Anon J, Sipmann F, Muniz G, Castellanos-Ortega A, Adell-Serrano B, Catalan M, de la Gandara A, Ricart P, Carbajales C, Rodriguez A, Diaz E, de la Torre M, Gallego E, Canton-Bulnes L, Carbonell N, Gonzalez J, de Gonzalo-Calvo D, Barbe F, Torres A. The European Respiratory Journal. 2023 Mar 2;61(3):2201426. doi: 10.1183/13993003.01426-2022. PMID: 36396142

Key factors associated with pulmonary sequelae in the follow-up of critically ill covid-19 patients. Gonzalez J, de Batlle J, Benitez I, Torres G, Santisteve S, Targa A, Gort-Paniello C, Moncusi-Moix A, Aguila M, Seck F, Ceccato A, Ferrer R, Motos A, Riera J, Fernandez L, Menendez R, Lorente J, Penuelas O, Garcia-Gasulla D, Penasco Y, Ricart P, Abril Palomares E, Aguilera L, Rodriguez A, Boado Varela M, Betere B, Pozo-Laderas J, Sole-Violan J, Salvador-Adell I, Novo M, Barberan J, Amaya Villar R, Garnacho-Montero J, Gomez J, Blandino Ortiz A, Tamayo Lomas L, Ubeda A, Catalan-Gonzalez M, Sanchez-Miralles A, Martinez Varela I, Jorge Garcia R, Franco N, Gumucio-Sanguino V, Bustamante-Munguira E, Valdivia L, Caballero J, Gallego E, Rodriguez C, Castellanos-Ortega A, Trenado J, Marin-Corral J, Albaiceta G, de la Torre M, Loza-Vazquez A, Vidal P, Anon J, Carbajales Perez C, Sagredo V, Carbonell N, Socias L, Barbera C, Estella A, Diaz E, de Gonzalo-Calvo D, Torres A, Barbe F. Archivos de Bronconeumologia. 2023 Jan 7:S0300-2896(23)00006-6. doi: 10.1016/j.arbres.2022.12.017. PMID: 36690515

The Biofire Filmarray Pneumonia Plus panel for management of lower respiratory tract infection in mechanically-ventilated patients in the COVID-19 era: a diagnostic and cost-benefit evaluation. Ferrer J, Clari M, Gimenez E, Carbonell N, Torres I, Blasco M, Albert E, Navarro D. Diagnostic Microbiology and Infectious Disease. 2023 Feb;105(2):115847. doi: 10.1016/j.diagmicrobio.2022.11584. PMID: 36403558

The intricate role of non-coding RNAs in sepsis-associated disseminated intravascular coagulation. Canovas Cervera I, Nacher Sendra E, Osca Verdegal R, Dolz Andres E, Beltran Garcia J, Rodriguez Gimillo M, Ferrando Sanchez C, Carbonell N, Garcia Gimenez JL. International Journal of Molecular Sciences. 2023 Jan 30;24(3):2582. doi: 10.3390/ijms24032582. PMID: 36768905

Autoantibodies against type I IFNs in patients with critical influenza pneumonia. Zhang Q, Pizzorno A, Miorin L, Bastard P, Gervais A, Le Voyer T, Bizien L, Manry J, Rosain J, Philippot Q, Goavec K, Padey B, Cupic A, Laurent E, Saker K, Vanker M, Sarekannu K, Garcia-Salum T, Ferres M, Le Corre N, Sanchez-Cespedes J, Balsera-Manzanero M, Carratala J, Retamar-Gentil P, Abelenda-Alonso G, Valiente A, Tiberghien P, Zins M, Debette S, Meyts I, Haerynck F, Castagnoli R, Notarangelo LD, Gonzalez-Granado LI, Dominguez-Pinilla N, Andreakos E, Triantafyllia V, Rodriguez-Gallego C, Sole-Violan J, Ruiz-Hernandez JJ, Rodriguez de Castro F, Ferreres J, Briones M, Wauters J, Vanderbeke L, Feys S, Kuo CY, Lei WT, Ku CL, Tal G, Etzioni A, Hanna S, Fournet T, Casalegno JS, Queromes G, Argaud L, Javouhey E, Rosa-Calatrava M, Cordero E, Aydillo T, Medina RA, Kisand K, Puel A, Jouanguy E, Abel L, Cobat A, Trouillet-Assant S, Garcia-Sastre A, Casanova JL. Journal of Experimental Medicine. 2022 Nov 7;219(11):e20220514. doi: 10.1084/jem.20220514. PMID: 36112363

CAPA in progress: a new real-life approach for the management of critically ill COVID-19 patients. Carbonell N, Alcaraz M, Serrano-Lazaro A, Rodriguez-Gimillo M, Ramos D, Ros F, Ferrer J, Blasco M, Navarro D, Clari M. Biomedicines. 2022 Jul 13;10(7):1683. doi: 10.3390/biomedicines10071683. PMID: 35884988

Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock. Beltran-Garcia J, Osca-Verdegal R, Javega B, Herrera G, O’Connor J, Garcia-Lopez E, Casabo-Valles G, Rodriguez-Gimillo M, Ferreres J, Carbonell N, Pallardo F, Garcia-Gimenez J. Biomedicines. 2022 Feb 23;10(3):525. doi: 10.3390/biomedicines10030525. PMID: 35327327

CIBERER: Spanish national network for research on rare diseases: a highly productive collaborative initiative. Luque J, Mendes I, Gomez B, Morte B, de Heredia M, Herreras E, Corrochano V, Bueren J, Gallano P, Artuch R, Fillat C, Perez-Jurado L, Montoliu L, Carracedo A, Millan J, Webb S, Palau F, Lapunzina P, Pallardo Calatayud F, CIBERER Network. Clinical Genetics. 2022 May;101(5-6):481-493. doi: 10.1111/cge.14113. PMID: 35060122

Combined kinetic analysis of SARS-CoV-2 RNAemia, N-antigenemia and virus-specific antibodies in critically ill adult COVID-19 patients. Costa R, Alberola J, Olea B, Gozalbo-Rovira R, Gimenez E, Cuevas-Ferrando E, Torres I, Albert E, Carbonell N, Ferreres J, Sanchez G, Rodriguez-Diaz J, Blasco M, Navarro D. Scientific Reports. 2022 May 18;12(1):8273. doi: 10.1038/s41598-022-12461-5. PMID: 35585163

Extracellular histones activate endothelial NLRP3 inflammasome and are associated with a severe sepsis phenotype. Beltrán-García J, Osca-Verdegal R, Pérez-Cremades D, Novella S, Hermenegildo C, Pallardó FV, García-Giménez JL. Journal of Inflammation Research. 2022 Jul 25;15:4217-4238. doi: 10.2147/JIR.S363693. PMID: 35915852

Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells. Perez-Cremades D, Bueno-Beti C, Garcia-Gimenez J, Ibanez-Cabellos J, Pallardo F, Hermenegildo C, Novella S. Journal of Physiology and Biochemistry. 2022 Dec 5. doi: 10.1007/s13105-022-00935-z. PMID: 36464762

Histone citrullination mediates a protective role in endothelium and modulates inflammation. Osca-Verdegal R, Beltran-Garcia J, Paes A, Nacher-Sendra E, Novella S, Hermenegildo C, Carbonell N, Garcia-Gimenez J, Pallardo F. Cells. 2022 Dec 15;11(24):4070. doi: 10.3390/cells11244070. PMID: 36552833

Identification of circulating miRNAs differentially expressed in patients with Limb-girdle, Duchenne or facioscapulohumeral muscular dystrophies. Garcia-Gimenez JL, Garcia-Trevijano ER, Aviles-Alia AI, Ibanez-Cabellos JS, Bovea-Marco M, Bas T, Pallardo FV, Vina JR, Zaragoza R. Orphanet Journal of Rare Diseases. 2022 Dec 27;17(1):450. doi: 10.1186/s13023-022-02603-3. PMID: 36575500

Initial SARS-CoV-2 RNA load in nasopharyngeal specimens is not associated with severity and midterm resolution of pneumonia in COVID-19 patients. Costa R, Signes-Costa J, Olea B, Tarraso J, Carbonell N, Blasco M, Navarro D. Journal of Infection. 2022 Dec;85(6):702-769. doi: 10.1016/j.jinf.2022.10.031. PMID: 36346264

Long non-coding RNAs as epigenetic regulators of immune checkpoints in cancer immunity. Saadi W, Fatmi A, Pallardo FV, Garcia-Gimenez JL, Mena-Molla S. Cancers. 2022 Dec 28;15(1):184. doi: 10.3390/cancers15010184. PMID: 36612180

Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study. Torres A, Motos A, Cilloniz C, Ceccato A, Fernandez-Barat L, Gabarrus A, Bermejo-Martin J, Ferrer R, Riera J, Perez-Arnal R, Garcia-Gasulla D, Penuelas O, Lorente J, de Gonzalo-Calvo D, Almansa R, Menendez R, Palomeque A, Villar R, Anon J, Marino A, Barbera C, Barberan J, Ortiz A, Boado M, Bustamante-Munguira E, Caballero J, Canton-Bulnes M, Perez C, Carbonell N, Catalan-Gonzalez M, de Frutos R, Franco N, Galban C, Gumucio-Sanguino V, de la Torre M, Diaz E, Estella A, Gallego E, Garmendia J, Gomez J, Huerta A, Garcia R, Loza-Vazquez A, Marin-Corral J, Delgado M, de la Gandara A, Varela I, Messa J, Albaiceta G, Nieto M, Novo M, Penasco Y, Perez-Garcia F, Pozo-Laderas J, Ricart P, Sagredo V, Sanchez-Miralles A, Chinesta S, Serra-Fortuny M, Socias L, Sole-Violan J, Suarez-Sipmann F, Lomas L, Trenado J, Ubeda A, Valdivia L, Vidal P, Barbe F. Intensive Care Medicine. 2022 Jul;48(7):850-864. doi: 10.1007/s00134-022-06726-w. PMID: 35727348

MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. Morales-Rosello J, Loscalzo G, Garcia-Lopez EM, Ibanez Cabellos JS, Garcia-Gimenez JL, Canada Martinez AJ, Perales Marin A. Epigenetics. 2022 Nov;17(11):1345-1356. doi: 10.1080/15592294.2021.2023271. PMID: 34969362

Monitoring of Torque Teno virus DNAemia in critically ill COVID-19 patients: may it help to predict clinical outcomes?. Forque L, Albert E, Gimenez E, Torres I, Carbonell N, Ferreres J, Blasco M, Navarro D. Journal of Clinical Virology. 2022 Jan 23;148:105082. doi: 10.1016/j.jcv.2022.105082. PMID: 35091226

Neurodevelopmental outcome and epigenetic changes at 2 years associated with the oxygen load received upon postnatal stabilization: a pilot study. Lorente-Pozo S, Boronat N, Parra-Llorca A, Lara-Canton I, Solaz-Garcia A, Soler J, Buso E, Casabo-Valles G, Garcia-Gimenez J, Pallardo F, Vento M. Neonatology. 2022;119(5):575-584. doi: 10.1159/000525305. PMID: 35760056

Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study. Cilloniz C, Motos A, Castaneda T, Gabarrus A, Barbe F, Torres A, CIBERESUCICOVID Project (COV20/00110 ISCIII). Journal of Infection. 2022 Dec 31:S0163-4453(22)00753-8. doi: 10.1016/j.jinf.2022.12.027. PMID: 36596315

SARS-CoV-2 N-antigenemia in critically ill adult COVID-19 patients: frequency and association with inflammatory and tissue-damage biomarkers. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Medical Virology. 2022 Jan;94(1):222-228. doi: 10.1002/jmv.27300. PMID: 34449894

SARS-CoV-2-reactive IFN-gamma-producing CD4+ and CD8+ T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients. Olea B, Albert E, Gimenez E, Torres I, Amat P, Remigia M, Alberola J, Carbonell N, Ferreres J, Blasco M, Navarro D. Scientific Reports. 2022 Aug 22;12(1):14271. doi: 10.1038/s41598-022-18659-x. PMID: 35995830

The endothelial glycocalyx and neonatal sepsis. Fatmi A, Saadi W, Beltran-Garcia J, Garcia-Gimenez JL, Pallardo FV. International Journal of Molecular Sciences. 2022 Dec 26;24(1):364. doi: 10.3390/ijms24010364. PMID: 36613805

The genetic diversity and dysfunctionality of catalase associated with a worse outcome in Crohn’s Disease. Iborra M, Moret I, Buso E, Garcia-Gimenez J, Ricart E, Gisbert J, Cabre E, Esteve M, Marquez-Mosquera L, Garcia-Planella E, Guardiola J, Pallardo F, Serena C, Algaba-Chueca F, Domenech E, Nos P, Beltran B. International Journal of Molecular Sciences. 2022 Dec 14;23(24):15881. doi: 10.3390/ijms232415881. PMID: 36555526

Clinical and immunological aspects of microRNAs in neonatal sepsis. Fatmi A, Chabni N, Cernada M, Vento M, Gonzalez-Lopez M, Aribi M, Pallardo FV, Garcia-Gimenez JL. Biomedicine & Pharmacotherapy. 2021 Nov 19;145:112444. doi: 10.1016/j.biopha.2021.112444. PMID: 34808550

Comparative analysis of chromatin-delivered biomarkers in the monitoring of sepsis and septic shock: a pilot study. Beltran-Garcia J, Manclus J, Garcia-Lopez E, Carbonell N, Ferreres J, Rodriguez-Gimillo M, Garces C, Pallardo F, Garcia-Gimenez J, Montoya A, Roma-Mateo C. International Journal of Molecular Sciences. 2021 Sep 14;22(18):9935. doi: 10.3390/ijms22189935. PMID: 34576097

DNA Methylation Analysis to Unravel Altered Genetic Pathways Underlying Early Onset and Late Onset Neonatal Sepsis. A Pilot Study. Lorente-Pozo S, Navarrete P, Garzón MJ, Lara-Cantón I, Beltrán-García J, Osca-Verdegal R, Mena-Mollá S, García-López E, Vento M, Pallardó FV, García-Giménez JL. Frontiers in Immunology. 2021 Feb 15;12:622599. doi: 10.3389/fimmu.2021.622599. PMID: 33659006

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers. Garcia-Gimenez J, Mena-Molla S, Tarazona-Santabalbina F, Vina J, Gomez-Cabrera M, Pallardo F. International Journal of Environmental Research and Public Health. 2021 Feb 15;18(4):1883. doi: 10.3390/ijerph18041883. PMID: 33672064

Lower respiratory tract and plasma SARS-CoV-2 RNA load in critically ill adult COVID-19 patients: Relationship with biomarkers of disease severity. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Infection. 2021 Sep;83(3):381-412. doi: 10.1016/j.jinf.2021.05.036. PMID: 34087349

Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved. Loscalzo G, Scheel J, Ibañez-Cabellos JS, García-Lopez E, Gupta S, García-Gimenez JL, Mena-Mollá S, Perales-Marín A, Morales-Roselló J. International Journal of Molecular Sciences. 2021 Dec 28;23(1):293. doi: 10.3390/ijms23010293. PMID: 35008715

Oxidative stress and rare diseases: from molecular crossroads to therapeutic avenues. Roma-Mateo C, Garcia-Gimenez J. Antioxidants. 2021 Apr 16;10(4):617. doi: 10.3390/antiox10040617. PMID: 33923815

Oxidative stress-mediated alterations in histone post-translational modifications. Garcia-Gimenez J, Garces C, Roma-Mateo C, Pallardo F. Free Radical Biology & Medicine. 2021 Jul;170:6-18. doi: 10.1016/j.freeradbiomed.2021.02.027. PMID: 33689846

Role of microRNAs as biomarkers in sepsis-associated encephalopathy. Osca-Verdegal R, Beltran-Garcia J, Pallardo FV, Garcia-Gimenez JL. Molecular Neurobiology. 2021 Sep;58(9):4682-4693. doi: 10.1007/s12035-021-02445-3. PMID: 34160774

Role of non-coding RNAs as biomarkers of deleterious cardiovascular effects in sepsis. Beltran Garcia J, Osca Verdegal R, Nacher Sendra E, Cardona Monzonis A, Sanchis Gomar F, Carbonell N, Pallardo FV, Lavie CJ, Garcia Gimenez JL. Progress in Cardiovascular Diseases. 2021;68:70-77. doi: 10.1016/j.pcad.2021.07.005. PMID: 34265333

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients. Torres A, Motos A, Riera J, Fernandez-Barat L, Ceccato A, Perez-Arnal R, Garcia-Gasulla D, Penuelas O, Lorente J, Rodriguez A, de Gonzalo-Calvol D, Almansa R, Gabarrus A, Menendez R, Bermejo-Martin J, Ferrer R, Villar R, Anon J, Barbera C, Barberan J, Ortiz A, Bustamante-Munguira E, Caballero J, Carbajales C, Carbonell N, Catalan-Gonzalez M, Galban C, Gumucio-Sanguino V, de la Torre M, Diaz E, Estella A, Gallego E, Garmendia J, Garnacho-Montero J, Gomez J, Huerta A, Garcia R, Loza-Vazquez A, Marin-Corral J, de la Gandara A, Varela I, Messa J, Albaiceta G, Novo M, Penasco Y, Pozo-Laderas J, Ricart P, Salvador-Ade I, Sanchez-Miralles A, chinesta S, Socias L, Sole-Violan J, Sipmann F, Lomas L, Trenado J, Barbe F, CIBERESUCICOVID Project Cov20 0011, ISCIII. Critical Care. 2021 Sep 13;25(1):331. doi: 10.1186/s13054-021-03727-x. PMID: 34517881

Acute depletion of telomerase components DKC1 and NOP10 induces oxidative stress and disrupts ribosomal biogenesis via NPM1 and activation of the P53 pathway. Ibañez Cabellos S, Seco Cervera M, Picher Latorre C, Pérez Machado G, Garcia Gimenez J, Pallardo Calatayud F. Biochimica Et Biophysica Acta-Molecular. Cell Research. 2020 Dec;1867(12):118845. doi: 10.1016/j.bbamcr.2020.118845. PMID: 32910990

Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance. Beltrán García J, Osca Verdegal R, Nacher-Sendra E, Pallardo Calatayud F, Garcia Gimenez J. Cells. 2020 Jun 25;9(6):1544. doi: 10.3390/cells9061544. PMID: 32630422

Circulating miRNA expression analysis reveals new potential biomarkers for human cutaneous melanoma staging. Sanchez Sendra B, Garcia Gimenez J, González Muñoz J, Navarro Cerveró L, Murgui A, Terradez Mas L, Pinazo Canales M, Martin Hernandez J, Monteagudo Castro C. Journal of the European Academy of Dermatology and Venereology. 2020 Mar;34(3):e126-e129. doi: 10.1111/jdv.16060. PMID: 31710393

Cofilin dysregulation alters actin turnover in frataxin-deficient neurons. Muñoz Lasso D, Molla B, Calap Quintana P, Garcia Gimenez J, Pallardo Calatayud F, Palau F, González Cabo P. Scientific Reports. 2020 Mar 23;10(1):5207. doi: 10.1038/s41598-020-62050-7. PMID: 32251310

Correction to: miRNA-23b as a biomarker of culture-positive neonatal sepsis. Fatmi A, Rebiahi S, Chabni N, Zerrouki H, Azzaoui H, Elhabiri Y, Benmansour S, Ibanez-Cabellos J, Smahi M, Aribi M, Garcia-Gimenez J, Pallardo F. Molecular Medicine. 2020 Dec 14;26(1):129. doi: 10.1186/s10020-020-00257-0. PMID: 33317443

Epigenetic biomarkers for human sepsis and septic shock: insights from immunosuppression. Beltrán García J, Osca-Verdegal R, Roma Mateo C, Carbonell Monleon N, Ferreres Franco J, Rodriguez M, Mulet Mascarell S, Garcia-Lopez E, Pallardo Calatayud F, Garcia Gimenez J. Epigenomics. 2020 Apr;12(7):617-646. doi: 10.2217/epi-2019-0329. PMID: 32396480

From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis. Perez-Machado G, Berenguer-Pascual E, Bovea-Marco M, Rubio-Belmar P, Garcia-Lopez E, Garzon M, Mena Molla S, Pallardo Calatayud F, Bas T, Viña Ribes J, Garcia Gimenez J. Bone. 2020 Nov;140:115563. doi: 10.1016/j.bone.2020.115563. PMID: 32768685

Impact of periodontal treatment on the RANKL/OPG ratio in crevicular fluid. López Roldán A, Garcia Gimenez J, Alpiste Illueca F. PLoS One. 2020 Jan 27;15(1):e0227757. doi: 10.1371/journal.pone.0227757. PMID: 31986169

MicroRNA-148b-3p and MicroRNA-25-3p Are Overexpressed in Fetuses with Late-Onset Fetal Growth Restriction. Morales-Rosello J, Garcia Gimenez J, Martinez Priego L, Gonzalez-Rodriguez D, Mena Molla S, Maquieira Catala A, Loscalzo G, Buongiorno S, Jakaite V, Canada Martinez A, Perales Marin A. Fetal Diagnosis and Therapy. 2020;47(9):665-674. doi: 10.1159/000507619. PMID: 32585676

miRNA-23b as a biomarker of culture-positive neonatal sepsis. Fatmi A, Rebiahi S, Chabni N, Zerrouki H, Azzaoui H, Elhabiri Y, Benmassour S, Ibañez Cabellos S, Smahi M, Aribi M, Garcia Gimenez J, Pallardo Calatayud F. Molecular medicine. 2020 Oct 8;26(1):94. doi: 10.1186/s10020-020-00217-8. PMID: 33032520

Non-coding RNAs and Coronary Artery Disease. Cardona-Monzonis A, Garcia Gimenez J, Mena Molla S, Pareja Galeano H, De La Guia-Galipienso F, Lippi G, Pallardo Calatayud F, Sanchis Gomar F. Advances in Experimental Medicine and Biology. 2020;1229:273-285. doi: 10.1007/978-981-15-1671-9_16. PMID: 32285418

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression. Beltrán García J, Osca Verdegal R, Pallardo Calatayud F, Ferreres Franco J, Rodríguez González M, Mulet Mascarell S, Sanchis Gomar F, Carbonell Monleon N, Garcia Gimenez J. Antioxidants (Basel, Switzerland). 2020 Sep 29;9(10):936. doi: 10.3390/antiox9100936. PMID: 33003552

Oxygen in the neonatal period: Oxidative stress, oxygen load and epigenetic changes. Lorente-Pozo S, Parra-Llorca A, Lara-Canton I, Solaz A, Garcia Gimenez J, Pallardo Calatayud F, Vento M. Seminars in Fetal & Neonatal Medicine. 2020 Apr;25(2):101090. doi: 10.1016/j.siny.2020.101090. PMID: 32014366

Reactive Glia-Derived Neuroinflammation: a Novel Hallmark in Lafora Progressive Myoclonus Epilepsy That Progresses with Age. Lahuerta M, Gonzalez D, Aguado C, Fathinajafabadi A, Garcia Gimenez J, Moreno-Estelles M, Roma Mateo C, Knecht E, Pallardo Calatayud F, Sanz P. Molecular Neurobiology. 2020 Mar;57(3):1607-1621. doi: 10.1007/s12035-019-01842-z. PMID: 31808062

Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches. Beltrán García J, Osca Verdegal R, Pallardo Calatayud F, Ferreres Franco J, Rodríguez González M, Mulet Mascarell S, Ferrando Sánchez C, Carbonell Monleon N, Garcia Gimenez J. Critical Care Medicine. 2020 Aug 18;10.1097/CCM.0000000000004625. doi: 10.1097/CCM.0000000000004625. PMID: 32826431

Thioredoxin and Glutaredoxin Systems as Potential Targets for the Development of New Treatments in Friedreich’s Ataxia. Seco-Cervera M, Gonzalez-Cabo P, Pallardo F, Roma-Mateo C, Garcia-Gimenez J. Antioxidants. 2020 Dec 10;9(12):E1257. doi: 10.3390/antiox9121257. PMID: 33321938

Projects
Reference: PI22/00990
Title: Biomarcadores de pronóstico de Escoliosis Idiopática en Adolescentes
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Salvador Mena Mollá
Duration: 2023 – 2025
Total budget: 123.420 €
Reference: CPP2021-008643
Title: Identificación y validación de biomarcadores mediante el uso de las ómicas y la Inteligencia Artificial para el diagnóstico temprano y mejora del manejo clínico de la sepsis
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Edurne Carbonell
Duration: 2022 – 2024
Total budget: 150.269 €
Reference: DTS21/00193
Title: Test basados en péptidos spike-in y espectrometría de masas para la cuantificación de histonas circulantes y proteína APC, para el manejo clínico del paciente crítico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Jose Luis García Giménez
Duration: 2022 – 2023
Total budget: 122.100 €
Reference: FIPSE 3819-21
Title: Valorización e internacionalización de HistShock, un test IVD para el diagnóstico y pronóstico de la sepsis y el shock séptico
Funding body: Fundación para la Innovación y Prospectiva en Salud en España (FIPSE)
Principal Investigator: José Luis García Giménez
Duration: 2021 – 2021
Total budget: 30.000 €
Reference: INNVA1/2020/85
Title: Valorización, estrategia de protección y transferencia de un método de diagnóstico y pronóstico de la sepsis y el shock séptico
Funding body: Agencia Valenciana de la Innovación-AVI Generalitat Valenciana
Principal Investigator: Jose Luis García Giménez
Duration: 2020 – 2021
Total budget: 110.670 €
Reference: PI19/00994
Title: Biomarcadores epigenéticos en sepsis y su implicación en inmunosupresión y futuras comorbilidades en supervivientes
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Luis García Giménez
Duration: 2020 – 2022
Total budget: 111.320 €
Reference: RTC2019-006825-1
Title: Potencial de la leriglitazona para el tratamiento de enfermedades asociadas a la acumulación de hierro, distrofias y enfermedades neuromusculares
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Pilar González Cabo
Duration: 2020 – 2023
Total budget: 90.000 €
Reference: INNTA2/2020/4
Title: Incorporación de investigadores y tecnólogos para proyectos de innovación en empresas
Funding body: Agencia Valenciana de Innovación (AVI)
Principal Investigator: José Luis García Giménez
Duration: 2020 – 2021
Total budget: 33.013 €
Reference: ACCI-2018
Title: Validación de biomarcadores para el diagnóstico y el pronóstico de la sepsis neonatal
Funding body: CIBER de Enfermedades Raras (CIBERER-ISCIII)
Principal Investigator: José Luis García Giménez
Duration: 2019 – 2020
Total budget: 49.500 €
Reference: PI16/01036
Title: Epigenética e inmunosupresión. Uso de las histonas circulantes y sus modificaciones posttraduccionales como biomarcadores de diagnóstico y pronóstico en sepsis y shock séptico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Luis García Giménez
Duration: 2017 – 2019
Total budget: 87.725 €
+ Info
Company: EpiDisease
Starting year: 2014
Researchers: García Giménez, José Luis
Web: http://www.epidisease.com/

Title: Potencial uso de la tecnología basada en microARNs para el diagnóstico y pronóstico de la escoliosis idiopática del adolescente
Doctoral candidate: Berenguer Pascual, Ester
Director(s): García Giménez, José Luis; Pérez Machado, Giselle; Mena Mollá Salvador
Date of the defense: 10/02/2022
University: Universitat de València

Title: Uso de las histonas circulantes y sus modificaciones post-traduccionales como biomarcadores en sepsis y shock séptico
Doctoral candidate: Beltrán García, Jesús
Director(s): García Giménez, José Luis; Pallardó Calatayud, Federico
Date of the defense: 20/01/2022
University: Universitat de València

Title: Influencia de factores epigeneticos en el desarrollo de la escoliosis idiopatica del adolescente
Doctoral candidate: Rubio Belmar, Pedro Antonio
Director(s): Bas Hermida, Teresa; García Giménez, José Luis
Date of the defense: 27/05/2021
University: Universitat de València

Title: Búsqueda de MIARNS en fluido crevicular gingival: expresión diferencial en sujetos con periodontitis crónica avanzada
Doctoral candidate: Almiñana Pastor, Pedro José
Director(s): García Giménez, José Luis; Bagán Sebastián, Jose Vicente; López Roldán, Andrés
Date of the defense: 04/03/2021
University: Universitat de València