Research Group on Cardiometabolic Risk and Diabetes

Cardiovascular Area

In terms of scientific activity of the research group during 2022, our group is participating in the development of three competitive and multidisciplinary research projects that include the following aims:

– Project: Immunopharmacological modulation of the systemic inflammation associated to metabolic disorders. Search for new therapeutic targets and synthesis of novel drugs

– Project: Study of new inflammatory and angiogenic mechanisms associated to severe morbid obesity

– Project: Role of the inflammatory processes in metabolic diseases and associated complications

– Project: Evaluation of the efficacy of pharmacogenetics to improve the response to treatment in subjects with insufficiently controlled type 2 diabetes

Dr. José Tomás Real Collado
Dr. José Tomás Real Collado;

Dr. José Tomás Real Collado
Dr. Sergio Martínez Hervás  

Leading, R4

José Tomás Real Collado    
Sergio Martínez Hervás    
Juan Francisco Ascaso Gimilio

Established, R3

Francisco Javier Ampudia Blasco
Miguel Civera Andrés

Recognised/Emerging, R2

Blanca Alabadí Pardiñes
Vera Lucía Gomes Francisco    

First Stage, R1

Carlos Bea Serrano
Miriam Moriana Hernández

Collaborating Researchers

Ana Palanca Palanca
Esther Benito Casado


Pilar Aguilar Santaisabel

Administrative assistant
Accuracy of two continuous glucose monitoring devices during aerobic and high-intensity interval training in individuals with Type 1 diabetes. Cuerda Del Pino A, Martin-San Agustin R, Laguna Sanz A, Diez J, Palanca A, Rossetti P, Gumbau-Gimenez M, Ampudia-Blasco F, Bondia J. Diabetes Technology & Therapeutics. 2024 Jan 12. doi: 10.1089/dia.2023.0535. PMID: 38215205

Light deficiency in Apoe-/-mice increases atheroma plaque size and vulnerability by modulating local immunity. Hurtado-Genoves G, Herrero-Cervera A, Vinue A, Martin-Vano S, Aguilar-Ballester M, Taberner-Cortes A, Jimenez-Marti E, Martinez-Hervas S, Gonzalez-Navarro H. Biochimica Et Biophysica Acta. Molecular Basis Of Disease. 2024 Feb 8;1870(4):167052. doi: 10.1016/j.bbadis.2024.167052. PMID: 38336102

Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases?. Domingo E, Marques P, Francisco V, Piqueras L, Sanz M. Pharmacological Research. 2024 Jan 11:S0214-9168(23)00120-1. doi: 10.1016/j.arteri.2023.12.005. PMID: 38218355

Anthropometric measures of adiposity as markers of kidney dysfunction: a cross-sectional study. Vela-Bernal S, Facchetti R, Dell’Oro R, Quarti-Trevano F, Lurbe E, Mancia G, Grassi G. High Blood Pressure & Cardiovascular Prevention. 2023 Sep 27. doi: 10.1007/s40292-023-00600-6. PMID: 37755663

Atherogenic dyslipidaemia in type 2 diabetes mellitus: The PREDISAT study. Climent E, Millan J, Ascaso J, Suarez-Tembra M, Morillas C, Civeira F, Bellon J, Pedro-Botet J. Lipids. 2023 Jul;58(4):197-206. doi: 10.1002/lipd.12374. PMID: 37291984

CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction. Hueso L, Marques P, Morant B, Gonzalez-Navarro H, Ortega J, Real J, Sanz M, Piqueras L. Frontiers in Endocrinology. 2023 Apr 12;14:1154158. doi: 10.3389/fendo.2023.1154158. PMID: 37124725

Comparison of GLP-1 Receptor agonists and other glucose-lowering agents on cardiovascular outcomes in individuals with type 2 diabetes and obesity: a spanish real-world population-based study. Palanca A, Javier Ampudia-Blasco F, Miguel Calderon J, Sauri I, Martinez-Hervas S, Luis Trillo J, Redon J, Real J. Diabetes Research and Clinical Practice. 2023 Dec 22:111071. doi: 10.1016/j.diabres.2023.111071. PMID: 38142748

Digestive toxicity in cancer treatments. Bibliographic review. Influence on nutritional status. Alonso Dominguez T, Civera Andres M, Santiago Crespo J, Garcia Malpartida K, Botella Romero F. Endocrinologia, Diabetes y Nutricion. 2023 Feb;70(2):136-150. doi: 10.1016/j.endien.2023.02.004. PMID: 36868926

Estimating quadriceps and hamstrings strength through myoton among recreational athletes. Gacto-Sánchez M, Medina-Mirapeix F, Benítez-Martínez J, Montilla-Herrador J, Palanca A, Agustín R. Journal of Sport Rehabilitation. 2023 Jun 14;32(7):827-833. doi: 10.1123/jsr.2022-0437. PMID: 37611914

Excellent results in terms of weight loss and Type 2 Diabetes control are maintained 20 years after Roux-en-Y gastric bypass. Lapena-Rodriguez M, Cassinello-Fernandez N, Alfonso-Ballester R, Marti-Fernandez RM, Civera-Andres M, Ortega-Serrano J. Journal of Gastrointestinal Surgery. 2023 Nov;27(11):2580-2582. doi: 10.1007/s11605-023-05734-5. PMID: 37430093

Expert recommendations for using time-in-range and other continuous glucose monitoring metrics to achieve patient-centered glycemic control in people with diabetes. Bellido V, Aguilera E, Cardona-Hernandez R, Diaz-Soto G, Gonzalez Perez de Villar N, Picon-Cesar MJ, Ampudia-Blasco FJ. Journal of Diabetes Science and Technology. 2023 Sep;17(5):1326-1336. doi: 10.1177/19322968221088601. PMID: 35470692

How macronutrients and pancreatic enzyme supplements dose variability affect fat, protein and starch absorption in children with cystic fibrosis. Larriba R, Roca M, Masip E, Canada-Martinez A, Ribes-Koninckx C, Calvo-Lerma J. Digestive and Liver Disease. 2023 Apr;55(4):513-518. doi: 10.1016/j.dld.2022.11.006. PMID: 36435715

Impact of conducting a genetic study on the management of familial hypercholesterolemia. Marco-Benedi V, Cenarro A, Vila A, Real J, Tamarit J, Walther L, Diaz-Diaz J, Perea V, Civeira F, Vaz A. Journal of Clinical Lipidology. 2023 Nov-Dec;17(6):717-731. doi: 10.1016/j.jacl.2023.08.008. PMID: 37813710

Low muscle mass is associated with poorer glycemic control and higher oxidative stress in older patients with type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez-Hervas S, Gomez-Cabrera M, Real J. Nutrients. 2023 Jul 17;15(14):3167. doi: 10.3390/nu15143167. PMID: 37513585

Metabolomic signature and molecular profile of normal and degenerated human intervertebral disc cells. Francisco V, Eldjoudi D, Gonzalez-Rodriguez M, Ruiz-Fernandez C, Cordero-Barreal A, Marques P, Sanz M, Real J, Lago F, Pino J, Farrag Y, Gualillo O. Spine Journal. 2023 Oct;23(10):1549-1562. doi: 10.1016/j.spinee.2023.06.005. PMID: 37339697

Overview of cellular and soluble mediators in systemic inflammation associated with non-alcoholic fatty liver disease. Marques P, Francisco V, Martinez-Arenas L, Carvalho-Gomes A, Domingo E, Piqueras L, Berenguer M, Sanz M. International Journal of Molecular Sciences. 2023 Jan 24;24(3):2313. doi: 10.3390/ijms24032313. PMID: 36768637

Physical activity patterns in type 1 diabetes in Spain: The SED1 study. Gómez-Peralta F, Menéndez E, Conde S, Conget , Novials A, Olmedo I, Tinahones F, San Laureano F, de la Torre M, Carazo A, Hospital J, Nivela O, Menendez E, Cosmas L, Payeras F, Gómez I, Bayo J, Montalbán C, Gomez-Peralta F, de Luis D, Díaz-Soto G, López-Guzmán A, Santos-Mazo E, Jimenez L, Alvarez V, Samper B, Ballesteros A, Gómez B, Conget I, Perez-Maraver M, Soldevila B, Flores I, García M, Ricart W, Colet A, Biescas E, Ampudia-Blasco F, Hernandez-Mijares A, Sanchez-Juan C, Picó A, Escribano J, Montañana C, Pedro T, Abellán P, Rossetti P, Morales-Pérez F, Enciso F, González A, Guerrero D, Cano R, López J, Melero V, Martín J, Mira S, Serrano M, Sanfiel M, Pascual A, Gómez F, Fernández M, Illán F, Martínez A, Llenas L, Gaztambide S, Gómez C, Oleaga A, de Salinas M, López-Siguero J, Gómez-Gila A, Sancho A, Lozano M, Galán I, Caimari M, Cardona R, León M, González G, Diez F, Rodríguez P, Roldán B, del Villar N, Pérez P, Rica I, López I. BMC Sports Science Medicine and Rehabilitation. 2023 Jul 26;15(1):92. doi: 10.1186/s13102-023-00695-3. PMID: 37491278

Real-world evaluation of GLP-1 receptor agonist therapy persistence, adherence and therapeutic inertia among obese adults with Type 2 Diabetes. Palanca A, Ampudia Blasco F, Calderon J, Sauri I, Martinez Hervas S, Trillo J, Redon J, Real J. Diabetes Therapy. 2023 Apr;14(4):723-736. doi: 10.1007/s13300-023-01382-9. PMID: 36847952

Remission of graves disease after initiation of ocrelizumab in patients with multiple sclerosis. Casany-Fernandez R, Gascon-Gimenez F, Matarredona Solaz E, Pardo Lozano F, Dominguez-Moran J, Ferri Ciscar J, Real J. Thyroid. 2023 Feb;33(2):267-269. doi: 10.1089/thy.2022.0398. PMID: 36416241

Spanish Consensus on the use of isCGM in the management of patients with insulin therapy: the MONITOR Project. Ampudia-Blasco F, Ugarte-Abasolo E, Chico A, Garcia-Aleman J, Galan-Barroso M. Journal of Diabetes Science and Technology. 2023 Sep;17(5):1256-1264. doi: 10.1177/19322968221087270. PMID: 35466722

Vascular smooth muscle cell phenotype is modulated by ligands of the lymphotoxin β receptor and the tumor necrosis factor receptor. Martin-Vano S, Miralles-Abella A, Castano P, Hurtado-Genoves G, Aguilar-Ballester M, Herrero-Cervera A, Vinue A, Martinez-Hervas S, Gonzalez-Navarro H. Clinica e Investigacion en Arteriosclerosis. 2023 Jan-Feb;35(1):1-11. English, Spanish. doi: 10.1016/j.arteri.2022.05.003. PMID: 35738949

Which people with diabetes are treated with a disposable, half-unit insulin pen? A real-world, retrospective, database study in Spain. Ampudia-Blasco F, Duque N, Artime E, Caveda E, Spaepen E, Diaz-Cerezo S, de Santos M, Velasco D, Bahillo-Curieses M. Endocrinology, Diabetes & Metabolism. 2023 Nov;6(6):e451. doi: 10.1002/edm2.451. PMID: 37715339

A very rare variant in SREBF2, a possible cause of hypercholesterolemia and increased glycemic levels. Garcia-Garcia A, Martinez-Hervas S, Vernia S, Ivorra C, Pulido I, Martin-Escudero J, Casado M, Carretero J, Real J, Chaves F. Biomedicines. 2022 May 19;10(5):1178. doi: 10.3390/biomedicines10051178. PMID: 35625914

Adipokines in non-alcoholic fatty liver disease: are we on the road toward new biomarkers and therapeutic targets?. Francisco V, Sanz M, Real J, Marques P, Capuozzo M, Ait Eldjoudi D, Gualillo O. Biology. 2022 Aug 19;11(8):1237. doi: 10.3390/biology11081237. PMID: 36009862

Association of chemokines IP-10/CXCL10 and I-TAC/CXCL11 with insulin resistance and enhance leukocyte endothelial arrest in obesity. Moreno B, Hueso L, Ortega R, Benito E, Martinez Hervas S, Peiro M, Civera M, Sanz MJ, Piqueras L, Real JT. Microvascular Research. 2022 Jan;139:104254. doi: 10.1016/j.mvr.2021.104254. PMID: 34534571

Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players. Marques P, Domingo E, Rubio A, Martinez-Hervas S, Ascaso JF, Piqueras L, Real JT, Sanz MJ. Biomedicine & Pharmacotherapy. 2022 Jan;145:112460. doi: 10.1016/j.biopha.2021.112460. PMID: 34864314

Comprehensive management of risk factors in peripheral vascular disease. Expert consensus. Barrios V, Beato P, Brotons C, Campuzano R, Merino-Torres J, Mostaza J, Plana N, Rubio J, Comellas M. Revista Clinica Espanola. 2022 Feb;222(2):82-90. doi: 10.1016/j.rceng.2020.11.011. PMID: 34217671

Corticotroph cell hyperplasia as a rare cause of ACTH-dependent Cushing syndrome. Ferri J, Martinez-Ibanez J, Terradez L, Savall E, Martinez-Hervas S, Oller M, Lorente R, Ascaso J, Real J. Endocrinologia, Diabetes y Nutrición. 2022 Nov;69(9):694-701. doi: 10.1016/j.endien.2022.11.004. PMID: 36470644

Developing a simple and practical decision model to predict the risk of incident type 2 diabetes among the general population: The Study. Martinez-Hervas S, Morales-Suarez-Varela MM, Andres-Blasco I, Lara-Hernandez F, Peraita-Costa I, Real JT, Garcia-Garcia AB, Chaves FJ. European Journal of Internal Medicine. 2022 Aug;102:80-87. doi: 10.1016/j.ejim.2022.05.005. PMID: 35570127

Diabetes and the WHO Model List of Essential Medicines. Danne T, Ampudia-Blasco FJ, Mathieu C. Lancet Diabetes & Endocrinology. 2022 Jan;10(1):18-19. doi: 10.1016/S2213-8587(21)00322-3. PMID: 34919865

Effect of personality on blood glucose control in patients with type 1 diabetes. Gu Hong W, Ferri J, Ampudia-Blasco F, Martin-Brufau R, Peiro M, Benito E, Martinez-Hervas S, Sanz M, Real J. Endocrinologia, Diabetes y Nutricion. 2022 Nov;69(9):677-685. doi: 10.1016/j.endien.2021.11.034. PMID: 36470643

Efficacy and safety of lomitapide in homozygous familial hypercholesterolaemia: the pan-European retrospective observational study. D’Erasmo L, Steward K, Cefalu A, Di Costanzo A, Boersma E, Bini S, Arca M, van Lennep J, Real Collado J, Italian and European Working Group on Lomitapide in HoFH. European Journal of Preventive Cardiology. 2022 May 5;29(5):832-841. doi: 10.1093/eurjpc/zwab229. PMID: 34971394

Efficacy of long-term treatment of autosomal recessive hypercholesterolemia with lomitapide: a subanalysis of the Pan-European Lomitapide Study. D’Erasmo L, Giammanco A, Suppressa P, Pavanello C, Iannuzzo G, Di Costanzo A, Tramontano D, Minicocci I, Bini S, Vogt A, Stewards K, Van Lennep J, Bertolini S, Arca M. Frontiers in Genetics. 2022 Aug 22;13:937750. doi: 10.3389/fgene.2022.937750. PMID: 36072671

First clinical and efficacy data on evolocumab in routine clinical practice in endocrinology and nutrition services in Spain: a retrospective observational study (RETOSS-ENDO). Pérez Pérez A, Ortega Martínez de Victoria E, Arrieta Blanco F, Caixàs Pedragós A, Santos Mazo E, Fernandez-Catalina P, Martínez-Hervas S, López-Medina JA, Suárez-Gutiérrez L, Urgeles Planelles JR, Gatell Menchén S, Tinahones Madueño F. Endocrinologia, Diabetes y Nutrición. 2022 Aug-Sep;69(7):540-542. doi: 10.1016/j.endien.2021.07.002. PMID: 35995680

Immune-mediated necrotising inflammatory myopathy. A rare side effect of statins. Alarcon Chulilla M, Avila Fuentes M, Casan Fernandez R, Muelas N, Real Collado J. Endocrinologia, Diabetes y Nutricion. 2022 Oct;69(8):648-649. doi: 10.1016/j.endien.2022.10.001. PMID: 36347793

Impact of COVID-19 lockdown on diabetes management and follow-up in a broad population in Spain. Palanca A, Quinones Torrelo C, Girbes J, Real JT, Ampudia Blasco FJ. European Journal of Clinical Investigation. 2022 Jun;52(6):e13771. doi: 10.1111/eci.13771. PMID: 35313009

Novel therapies for cardiometabolic disease: recent findings in studies with hormone peptide-derived G protein coupled receptor agonists. Jimenez-Marti E, Hurtado-Genoves G, Aguilar-Ballester M, Martinez-Hervas S, Gonzalez-Navarro H. Nutrients. 2022 Sep 13;14(18):3775. doi: 10.3390/nu14183775. PMID: 36145148

Real-world data of anticoagulant treatment in non-valvular atrial fibrillation. Calderon J, Martinez F, Diaz J, Fernandez A, Sauri I, Uso R, Trillo J, Vela S, Bea C, Redon J, Forner M. Frontiers In Cardiovascular Medicine. 2022 Jan 21;8:733300. doi: 10.3389/fcvm.2021.733300. PMID: 35127843

Real-world evidence of efficacy and safety of SGLT2 inhibitors as adjunctive therapy in adults with Type 1 Diabetes: a European two-center experience. Palanca A, van Nes F, Pardo F, Ampudia Blasco FJ, Mathieu C. Diabetes Care. 2022 Mar 1;45(3):650-658. doi: 10.2337/dc21-1584. PMID: 35061022

Recommendations on the use of telemedicine as applied to nutritional pathology. Abad Gonzalez AL, Civera Andres M, Argente Pla M, Garcia Malpartida K, Olivares Alcolea J, Dominguez Escribano JR, Ferrer Gomez M, Gonzalez Boillos M, Hervas Abad E, Negueruela Avella GI, Urgeles Planella JR, Veses Martin S, Sanchez JC. Nutricion Hospitalaria. 2022 Aug 25;39(4):863-875. doi: 10.20960/nh.03923. PMID: 35312336

SEA 2022 standards for global control of cardiovascular risk. Mostaza J, Pinto X, Armario P, Masana L, Real J, Valdivielso P, Arrobas-Velilla T, Baeza-Trinidad R, Calmarza P, Cebollada J, Civera-Andres M, Cuende Melero J, Diaz-Diaz J, Fernandez Pardo J, Guijarro C, Jerico C, Laclaustra M, Lahoz C, Lopez-Miranda J, Martinez-Hervas S, Muniz-Grijalvo O, Paramo J, Pascual V, Pedro-Botet J, Perez-Martinez P, Plana N, Puzo J, Sanchez Chaparro M, Vila L. Clinica e Investigacion en Arteriosclerosis. 2022 May-Jun;34(3):130-179. doi: 10.1016/j.arteri.2021.11.003. PMID: 35090775

The controversial role of vitamin D in thyroid cancer prevention. Palanca A, Ampudia-Blasco F, Real J. Nutrients. 2022 Jun 23;14(13):2593. doi: 10.3390/nu14132593. PMID: 35807774

Activation of the constitutive androstane receptor inhibits leukocyte adhesiveness to dysfunctional endothelium. Lopez-Riera M, Ortega R, Hueso L, Montesinos MC, Gomez-Cabrera MC, Sanz MJ, Real JT, Piqueras L. International Journal of Molecular Sciences. 2021 Aug 27;22(17):9267. doi: 10.3390/ijms22179267. PMID: 34502180

Anthropometric indicators as a tool for diagnosis of obesity and other health risk factors: a literature review. Piqueras P, Ballester A, Dura-Gil J, Martinez-Hervas S, Redon J, Real J. Frontiers in Psychology. 2021 Jul 9;12:631179. doi: 10.3389/fpsyg.2021.631179. PMID: 34305707

Conversations and Reactions Around Severe Hypoglycaemia (CRASH): Spanish results of a global survey of people with type 1 diabetes or insulin-treated type 2 diabetes and caregivers. Ampudia-Blasco F, Artime E, Diaz S, Rubio M, Reviriego J, Mitchell B, Osumili B, Peyrot M, Pokrzywinski R, Spaepen E, Snoek F. Endocrinologia, diabetes y nutrición. 2021 Oct;68(8):557-566. doi: 10.1016/j.endien.2021.11.012. PMID: 33461913

Dissecting abdominal aortic aneurysm is aggravated by genetic inactivation of LIGHT (TNFSF14). Herrero-Cervera A, Espinos-Estevez C, Martin-Vano S, Taberner-Cortes A, Aguilar-Ballester M, Vinue A, Piqueras L, Martinez-Hervas S, Gonzalez-Navarro H. Biomedicines. 2021 Oct 22;9(11):1518. doi: 10.3390/biomedicines9111518. PMID: 34829747

Efficacy and safety of adding sotagliflozin, a dual SGLT1 and SGLT2 inhibitor, to optimized insulin therapy in adults with type 1 diabetes and baseline BMI ?27 kg/m2. Danne T, Edelman S, Frias J, Ampudia-Blasco F, Banks P, Jiang W, Davies M, Sawhney S. Diabetes, Obesity & Metabolism. 2021 Mar;23(3):854-860. doi: 10.1111/dom.14271. PMID: 33289297

Frailty is associated with oxidative stress in older patients with Type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez-Hervas S, Gomez-Cabrera MC, Real JT. Nutrients. 2021 Nov 9;13(11):3983. doi: 10.3390/nu13113983. PMID: 34836238

Hypercholesterolemic patients have higher eryptosis and erythrocyte adhesion to human endothelium independently of statin therapy. Cilla A, Lopez-Garcia G, Collado-Diaz V, Blanch-Ruiz MA, Garcia-Llatas G, Barbera R, Martinez-Cuesta MA, Real JT, Alvarez A, Martinez-Hervas S. International Journal of Clinical Practice. 2021 Nov;75(11):e14771. doi: 10.1111/ijcp.14771. PMID: 34473881

NT3/TrkC pathway modulates the expression of ucp-1 and adipocyte size in human and rodent adipose tissue. Bove M, Monto F, Guillem-Llobat P, Ivorra M, Noguera M, Zambrano A, Sirerol-Piquer M, Requena A, Garcia-Alonso M, Tejerina T, Real J, Farinas I, D’Ocon P. Frontiers in Endocrinology. 2021 Mar 18;12:630097. doi: 10.3389/fendo.2021.630097. PMID: 33815288

Oral unsaturated fat load impairs postprandial systemic inflammation in primary hypercholesterolemia patients. Collado A, Domingo E, Marques P, Perello E, Martínez-Hervás S, Piqueras L, Ascaso JF, Real JT, Sanz MJ. Frontiers in Pharmacology. 2021 Apr 20;12:656244. doi: 10.3389/fphar.2021.656244. PMID: 33959024

Patient-reported outcomes in adults with type 1 diabetes in global real-world clinical practice: the SAGE study. Wilmot EG, Close KL, Jurisic-Erzen D, Bruttomesso D, Ampudia-Blasco FJ, Bosnyak Z, de Climens AR, Bigot G, Peters AL, Renard E, Berard L, Calliari LE, Seufert J. Diabetes, Obesity & Metabolism. 2021 Aug;23(8):1892-1901. doi: 10.1111/dom.14416. PMID: 33914401

Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes. Ascaso P, Palanca A, Martinez-Hervas S, Sanz MJ, Ascaso JF, Piqueras L, Real JT. International Journal of Clinical Practice. 2021 Aug;75(8):e14302. doi: 10.1111/ijcp.14302. PMID: 33930221

Postprandial triglyceridemia is modulated by insulin resistance but not by grade of obesity in abdominal and morbid obese subjects. Moreno-Perez B, Benito E, Civera M, Alabadi B, Martinez-Hervas S, Peiro M, Gonzalez-Navarro H, Piqueras L, Jesus Sanz M, Ascaso J, Real J. International Journal of Clinical Practice. 2021 Apr;75(4):e13776. doi: 10.1111/ijcp.13776. PMID: 33089594

The nuclear retinoid-related orphan receptor RORalpha controls adipose tissue inflammation in patients with morbid obesity and diabetes. Ortega R, Hueso L, Benito E, Ortega J, Civera M, Sanz M, Real J, Piqueras L. International Journal of Obesity. 2021 Jul;45(7):1369-1381. doi: 10.1038/s41366-021-00787-5. PMID: 33637954

Therapeutic inertia in patients with type 2 diabetes treated with non-insulin agents. Ampudia-Blasco F, Palanca A, Trillo J, Navarro J, Real J. Journal of diabetes and its complications. 2021 Mar;35(3):107828. doi: 10.1016/j.jdiacomp.2020.107828. PMID: 33436143

Therapies for the Treatment of Cardiovascular Disease Associated with Type 2 Diabetes and Dyslipidemia. Aguilar-Ballester M, Hurtado-Genoves G, Taberner-Cortes A, Herrero-Cervera A, Martinez-Hervas S, Gonzalez-Navarro H. International Journal Of Molecular Sciences. 2021 Jan 11;22(2):660. doi: 10.3390/ijms22020660. PMID: 33440821

Time-in-range for monitoring glucose control: Is it time for a change?. Bellido V, Pines-Corrales, PJ, Villar-Taibo R, Ampudia-Blasco FJ. Diabetes Research and Clinical Practice. 2021 Jun 11;177:108917. doi: 10.1016/j.diabres.2021.108917. PMID: 34126129

Urinary- and Plasma-Derived Exosomes Reveal a Distinct MicroRNA Signature Associated With Albuminuria in Hypertension. Perez-Hernandez J, Riffo-Campos A, Ortega A, Martinez-Arroyo O, Perez-Gil D, Olivares D, Solaz E, Martinez F, Martinez-Hervas S, Chaves F, Redon J, Cortes R. Hypertension. 2021 Mar 3;77(3):960-971. doi: 10.1161/HYPERTENSIONAHA.120.16598. PMID: 33486986

Reference: PI22/00062
Title: Identificación de nuevas dianas terapéuticas y mecanismos de la modulación de la inflamación en las enfermedades metabólicas
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Herminia González Navarro, Sergio Martínez Hervás
Duration: 2023 – 2025
Total budget: 147.620,00 €
Reference: INVEST/2022/470
Title: Investigación en Enfermedades Inflamatorias
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Vera Lucía Gomes Francisco
Duration: 2022 – 2024
Total budget: 66.218 €
Reference: ICI21/00020
Title: Evaluación de la eficacia de la farmacogenética para mejorar la respuesta al tratamiento en sujetos con diabetes tipo 2 insuficientemente controlada
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Sergio Martínez Hervás
Duration: 2022 – 2025
Total budget: 267.300 €
Reference: PMP21/00076
Title: ImpactT2D: una estrategia genómica para implementar medicina de precisión en la diabetes tipo 2
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2022 – 2025
Total budget: 106.700 €
Reference: PI21/00220
Title: Estudio de nuevos ejes de quimiocinas como potenciales dianas de intervención en la obesidad y la resistencia a la insulina
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Laura Piqueras Ruiz, José Tomas Real Collado
Duration: 2022 – 2024
Total budget: 204.490 €
Reference: PROMETEO/2019/032
Title: Una aproximación traslacional desde la clínica a la experimentación animal: Estudio del papel del eje CCL11/CCR3 y la inflamación eosinofílica en la patología cardiovascular asociada a desórdenes metabólicos
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Mª Jesús Sanz Ferrando
Duration: 2020 – 2023
Total budget: 211.736 €
Reference: PI19/00169
Title: Papel de los procesos inflamatorios en las enfermedades metabólicas y en las complicaciones asociadas
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Herminia González Navarro, Sergio Martínez Hervás
Duration: 2020 – 2022
Total budget: 159.720 €
Reference: PI18/00209
Title: Identificación de nuevos mecanismos implicados en la angiogénesis e inflamación en pacientes obesos. Modulación por ligandos de receptores nucleares constitutivos de androstano
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Laura Piqueras Ruiz, José Tomas Real Collado
Duration: 2019 – 2022
Total budget: 173.333 €
Reference: SAF2017-89714-R
Title: Modulación farmacológica del sistema inmune como diana clave en la prevención de la enfermedad cardiovascular asociada a desordenes metabólicos. Síntesis de fármacos novedosos
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Mª Jesús Sanz Ferrando, Juan F. Ascaso Gimilio
Duration: 2018 – 2021
Total budget: 205.700 €
Reference: CB07/08/0018
Title: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Tomás Real Collado
Duration: 2008 –
Total budget: 154.577 €
+ Info
Have the Government’s prescription algorithm and the 2013 American College of Cardiology/American Heart Association guidelines for managing dyslipidaemia influenced the management of dyslipidaemia?. The MEJORALO-CV Project. Giner Galvan V, Bonig Trigueros I, Facila Rubio L, Morillas Blasco P, Martinez Hervas S, Pascual Fuster V, Valls Roca F, Soler Portmann C, Tamarit Garcia J, Pallares Carratala V, Componentes del grupo de Trabajo MEJORALO-CV. Revista Clinica Espanola. 2020;220(5):282-289. doi: 10.1016/j.rce.2019.08.006. PMID: 31744620

Title: Estudio de la sarcopenia y la fragilidad en una población diabética de edad avanzada y su relación con parámetros de estrés oxidativo
Doctoral candidate: Alabadí Pardiñes, Blanca
Director(s): Real Collado, Jose Tomás; Civera Andrés, Miguel
Date of the defense: 11/11/2022
University: Universitat de València

Title: Effect of SGLT-2 inhibition in abdominal aortic aneurysm development. Role of rora in adipose tissue inflammation associated to obesity
Doctoral candidate: Ortega Herráiz, Rebeca
Director(s): Piqueras Ruiz, Laura; Sanz Ferrando, María Jesús; Real Collado, José Tomás
Date of the defense: 21/02/2022
University: Universitat de València

Title: La ecografía Doppler con flujo en color en el diagnóstico, tratamiento y pronóstico de la enfermedad de Graves-Basedow
Doctoral candidate: Rubio Puchol, Olalla
Director(s): Merchante Alfaro, Agustín Ángel; Martínez Hervás, Sergio
Date of the defense: 25/01/2022
University: Universitat de València

Title: Influencia de la situación postprandial sobre el eje CCL11/CCR3 en sujetos con hipercolesterolemia
Doctoral candidate: Perelló Camacho, Eva
Director(s): Ascaso Gimilio, Juan F; Real Collado, Jose Tomás
Date of the defense: 23/11/2020
University: Universitat de València

Title: Efecto de los parámetros epigenéticos tras dos años de la cirugía bariátrica
Doctoral candidate: Wu Xiong, Ning Yun
Director(s): Ascaso Gimilio, Juan F; Real Collado, Jose Tomás
Date of the defense: 22/09/2020
University: Universitat de València

Title: Identificación de variantes genéticas relacionadas con diabetes mellitus tipo 2 en población española
Doctoral candidate: Lendínez Tortajada, Verónica
Director(s): Chaves Martínez, Felipe Javier; Real Collado, Jose Tomás
Date of the defense: 31/01/2020
University: Universitat de València

Title: Metilación del ADN de adipocitos en sujetos con obesidad mórbida
Doctoral candidate: Martínez Ibáñez, Juncal
Director(s): Real Collado, Jose Tomás; Ascaso Gimilio, Juan F
Date of the defense: 22/07/2019
University: Universitat de València

Title: Lipemia postprandial y regulación génica en la obesidad mórbida
Doctoral candidate: Artero Fullana, Ana
Director(s): Real Collado, Jose Tomás; Ascaso Gimilio, Juan F
Date of the defense: 21/03/2019
University: Universitat de València