Research Group on Cardiac Experimental Electrophysiology
Cardiovascular Area
Publication of the results obtained on using the 1,4-benzothiazepine derivative JTV-519 to modify the proarrhythmogenic manifestations of mechanoelectric feedback and continuation of the programmed experimental series to analiyze the effects of KN-93, carvedilol and analogues, late Na+ current inhibitors and the Nitric Oxide carrier S-nitrosoglutathione.
Continuation of the analysis of the effects of modifications of the basic electrophysiological properties on the processes.
involved in the induction and maintenance of ventricular fibrillation
Analysis of the electrophysiological effects of chronic physical exercise and its protective effect against arrhythmias, the influence of the cardiac nervous system and mitochondrial oxidative stress and the involvement of the IKATP current.
Development of instruments for recording, processing and analysing cardiac electrophysiological signals obtained with mapping systems.
Progressive development of the experimental series aimed to study the mechanisms involved in the deterioration of the systolic function, fibrosis and the inducibility of arrhythmias in a chronic model of infarction.
Progressive development of an experimental model of metabolic syndrome to analyze the electrophysiological modifications and the inducibility of cardiac arrhythmias.
Coordinator
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Collaborating Researchers
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Administrative assistant
Publications
Risk of death associated with incident heart failure in patients with known or suspected chronic coronary síndrome. Nunez J, Lorenzo M, Minana G, Palau P, Monmeneu JV, Lopez-Lereu MP, Gavara J, Marcos-Garces V, Rios-Navarro C, Perez N, de Dios E, Nunez E, Sanchis J, Chorro FJ, Bayes-Genis A, Bodi V. ESC Heart Failure. 2023 Feb;10(1):264-273. doi: 10.1002/ehf2.14179. PMID: 36196583
Applicability of echocardiographic strict negative criteria for suspected infective endocarditis. Marcos-Garces V, Gabaldon-Perez A, Merenciano-Gonzalez H, Soler M, Lorenzo-Hernandez M, Nunez-Marin G, de la Espriella R, Bonanad C, Nunez J, Chorro FJ, Bodi V, Santas E. American Journal of Cardiology. 2022 Jan 1;162:156-162. doi: 10.1016/j.amjcard.2021.09.012. PMID: 34728063
Carbohydrate antigen 125 and risk of heart failure readmissions in patients with heart failure and preserved ejection fraction. Minana G, de la Espriella R, Palau P, Llacer P, Nunez E, Santas E, Valero E, Lorenzo M, Nunez G, Bodi V, Heredia R, Sanchis J, Bayes-Genis A, Chorro F, Nunez J. Scientific Reports. 2022 Jan 25;12(1):1344. doi: 10.1038/s41598-022-05328-2. PMID: 35079082
Combined assessment of stress cardiovascular magnetic resonance and angiography to predict the effect of revascularization in chronic coronary syndrome patients. Gavara J, Perez N, Marcos-Garces V, Monmeneu J, Lopez-Lereu M, Rios-Navarro C, de Dios E, Bonanad C, Canoves J, Moratal D, Palau P, Minana G, Nunez J, Chorro F, Bodi V. European Journal of Preventive Cardiology. 2022 Mar 11;29(2):407-416. doi: 10.1093/eurjpc/zwab170. PMID: 34686874
EpCAM and microvascular obstruction in patients with STEMI: a cardiac magnetic resonance study. Rios-Navarro C, Gavara J, Nunez J, Revuelta-Lopez E, Monmeneu JV, Lopez-Lereu MP, de Dios E, Perez-Sole N, Vila JM, Oltra R, Chorro FJ, Bayes-Genis A, Bodi V. Revista Espanola de Cardiologia (English ed.). 2022 May;75(5):384-391. doi: 10.1016/j.rec.2021.04.006. PMID: 34045168
Coronary Revascularization and Long-Term Survivorship in Chronic Coronary Syndrome. Gabaldon-Perez A, Marcos-Garces V, Gavara J, Rios-Navarro C, Minana G, Bayes-Genis A, Husser O, Sanchis J, Nunez J, Chorro F, Bodi V. Journal of Clinical Medicine. 2021 Feb 5;10(4):610. doi: 10.3390/jcm10040610. PMID: 33562869
Early urinary sodium trajectory and risk of adverse outcomes in acute heart failure and renal dysfunction. De La Espriella Juan R, Nuñez Benito E, Llàcer P, Garcia Blas S, Ventura Haro S, Núñez J, Sánchez R, Facila De La Esperanza R, Vaquer Santamaria J, Bodí Peris V, Santas Olmeda E, Miñana Escriva G, Mollar Fernandez A, Núñez Marín G, Chorro Gascó F, Górriz Teruel J, Sanchis Fores J, Bayés-Genis A, Nuñez Villota J. Revista Espanola de Cardiologia (English ed.). 2021 Jul;74(7):616-623. doi: 10.1016/j.rec.2020.06.004. PMID: 32624444
Effect of beta-blocker withdrawal on functional capacity in heart failure and preserved ejection fraction. Palau P, Seller J, Dominguez E, Sastre C, Ramon JM, Espriella R, Santas E, Minana G, Bodi V, Sanchis J, Valle A, Chorro FJ, Llacer P, Bayes-Genis A, Nunez J. Journal of the American College of Cardiology. 2021 Nov 23;78(21):2042-2056. doi: 10.1016/j.jacc.2021.08.073. PMID: 34794685
Efficacy of a proprioceptive exercise program in patients with nonspecific neck pain. A randomized controlled trial. Espí López G, Aguilar Rodríguez M, Zarzoso Muñoz M, Serra Año M, Martinez De La Fuente J, Inglés De La Torre M, Marques-Sule E. European Journal of Physical and Rehabilitation Medicine. 2021 Jun;57(3):397-405. doi: 10.23736/S1973-9087.20.06302-9. PMID: 33047944
A randomized controlled trial on carbohydrate antigen 125-guided diuretic treatment versus usual care in patients with acute heart failure and renal dysfunction. Nuñez Villota J, Llacer P, Garcia Blas S, Bonanad Lozano C, Ventura S, Nunez J, Sanchez R, Facila De La Esperanza R, De La Espriella Juan R, Vaquer Santamaria J, Cordero A, Roque M, Chamorro C, Bodí Peris V, Valero Picher E, Santas Olmeda E, Del Carmen Moreno M, Miñana Escriva G, Carratalá Calvo A, Rodriguez Borja E, Mollar Fernandez A, Palau P, Bosch M, Bertomeu-Gonzalez V, Lupon J, Navarro Perez J, Chorro Gascó F, Górriz Teruel J, Sanchis Fores J, Voors A, Bayes-Genis A, IMPROVE-HF Investigators. American Journal of Medicine. 2020 Mar;133(3):370-380.e4. doi: 10.1016/j.amjmed.2019.07.041. PMID: 31422111
Association between a comprehensive smoking ban and hospitalization for acute myocardial infarction: An observational study in the Autonomous Community of Valencia, Spain. Carrión Valero F, Quiles-Izquierdo J, Gonzalez-Monte C, Taberner Alberola F, Lluch Rodrigo J, Chorro Gascó F, Martín Moreno J. Revista Portuguesa de Cardiología. 2020 Feb;39(2):77-84. doi: 10.1016/j.repc.2019.04.009. PMID: 32291119
Beta-blockers withdrawal in patients with heart failure with preserved ejection fraction and chronotropic incompetence: Effect on functional capacity rationale and study design of a prospective, randomized, controlled trial (The Preserve-HR trial). Palau P, Seller J, Dominguez E, Gomez I, Ramón Ferrandis J, Sastre Arbona C, De La Espriella Juan R, Santas Olmeda E, Miñana Escriva G, Chorro Gascó F, Ramon Gonzalez-Juanatey J, Nuñez Villota J. Clinical Cardiology. 2020 May;43(5):423-429. doi: 10.1002/clc.23345. PMID: 32073676
CA125 outperforms NT-proBNP in acute heart failure with severe tricuspid regurgitation. Soler Costa M, Miñana Escriva G, Santas Olmeda E, Nuñez Benito E, De La Espriella Juan R, Valero Picher E, Bodí Peris V, Chorro Gascó F, Fernández Cisnal A, D’ascoli G, Marti-Cervera J, Sanchis Fores J, Bayes-Genis A, Nuñez Villota J. International Journal of Cardiology. 2020 Jun 1;308:54-59. doi: 10.1016/j.ijcard.2020.03.027. PMID: 32209267
Projects
Title: Efectos de la inhibición de SGLT2 sobre el remodelado auricular producido por el síndrome metabólico y su sustrato arritmogénico. Estudio experimental
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Francisco Javier Chorro Gascó, Manuel Zarzoso Muñoz
Duration: 2022 – 2024
Total budget: 99.220 €
Title: Resonancia magnética cardíaca de estrés con vasodilatadores para predecir la mortalidad a largo plazo en un amplio registro retrospectivo de pacientes con cardiopatía isquémica conocida o sospechada
Funding body: Sociedad Española de Cardiología
Principal Investigator: Vicent Bodí Peris
Duration: 2021 – 2022
Total budget: 15.000 €
Title: Modificacion de los efectos pro-arritmicos inducidos por la sobrecarga mecanica o el remodelado ventricular
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Francisco Javier Chorro Gascó
Duration: 2019 – 2021
Total budget: 129.470 €
Title: Mecanismos protectores frente ala muerte cardiaca súbita de causa arrítmica
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Francisco Javier Chorro Gascó
Duration: 2018 – 2021
Total budget: 275.859 €
Title: CIBER Cardiovascular (CIBERCV)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Francisco Javier Chorro Gascó
Duration: 2017 –
Total budget:
Title: Efectos de la inhibición de la desacetilación de las histonas en el remodelado post-infarto del sustrato arritmogénico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Francisco Javier Chorro Gascó
Duration: 2016 – 2019
Total budget: 93.170 €
Title: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicente Bodí Peris
Duration: 2016 – 2019
Total budget: 589.050 €
+ Info
Doctoral candidate: Gallego Rojas, Nathalia
Director(s): Guerrero Martínez, Juan; Parra Giraldo, Germán; Such Belenguer, Luis
Date of the defense: 22/07/2021
University: Universitat de València
Title: Efectos de la inhibición de la desacetilación de las histonas en el remodelado post-infarto del sustrato arritmogénico
Doctoral candidate: Genovés Martínez, Patricia
Director(s): Chorro Gascó, Francisco Javier; Such Belenguer, Luis; Del Canto Serrano, Irene
Date of the defense: 27/04/2021
University: Universitat de València
Title: Cambios en la activación electromiográfica de la musculatura de codo en sujetos sanos comparada con la activación muscular en sujetos con tendinopatía y la influencia de la aplicación de punción seca en la misma
Doctoral candidate: Hanna, Fredy
Director(s): Alakhdar Mohmara, Yasser; Alberola Aguilar, Antonio
Date of the defense: 23/04/2021
University: Universitat de València
Title: Estudio de la función miocárdica en la enfermedad renal crónica avanzada y en la terapia de sustitución renal
Doctoral candidate: Melero Lloret, Joana
Director(s): Chorro Gascó, Francisco Javier; Soriano Navarro, Carlos Joaquín
Date of the defense: 26/03/2021
University: Universitat de València
Title: Inherited arrhythmogenic cardiac diseases and the KIR2.1-NAV1.5 channelosome
Doctoral candidate: Jalife Sacal, José
Director(s): Chorro Gascó, Francisco Javier; Such Belenguer, Luís
Date of the defense: 18/12/2020
University: Universitat de València
Title: Implicación del canal katp en las modificaciones que la realización de ejercicio físico crónico produce sobre algunas propiedades electrofisiológicas en el miocardio. Estudio en corazón aislado sometido a isquemia global aguda
Doctoral candidate: Soler López, Carlos
Director(s): Such Belenguer, Luis; Chorro Gascó, Francisco Javier; Iradi Casal, Antonio
Date of the defense: 17/04/2019
University: Universitat de València
Title: Genetic and other intrinsic factors influencing risk for elbow tendinopathy
Doctoral candidate: McPeek, Emily Renae
Director(s): Alakhdar Mohmara, Yasser; Alberola Aguilar, Antonio
Date of the defense: 08/03/2019
University: Universitat de València