Genomics and Diabetes Unit
Cardiovascular Area
Our group aims to improve the life of the patient by identifying the genetic bases of Type 2 Diabetes and associated diseases and improving knowledge about the interactions of non-genetic factors with genetic and epigenetic ones. In addition to studying these complex diseases, we are also interested in the study of diseases related to intolerance/allergy to all foods, haematological malignancies and hereditary diseases that affect metabolism. Another area of interest of our group is the study of different viruses, such as rotavirus and norovirus, and their interaction with our organism and their infective activity.
In addition, we have a great interest in the development of both laboratory and bioinformatics applications that facilitate the diagnosis, treatment and monitoring of patients. To this end, we develop collaborations and studies focused on improving the diagnosis and monitoring of leukemia and other types of tumors.
Coordinator
STAFF
Collaborating Researchers
Nurse
Technicians
Administrative assistant
Publications
Corrigendum to Genetic interaction in the association between oxidative stress and diabetes in the Spanish population [Free Radic. Biol. Med. 205 (2023) 62-68]. Melero R, Quiroz-Rodríguez ME, Lara-Hernández F, Redón J, Sáez G, Briongos-Figuero LS, Abadía-Otero J, Martín-Escudero JC, Chaves FJ, Ayala G, García-García AB. Free Radical Biology & Medicine. 2023 Jul 22;207:181-182. doi: 10.1016/j.freeradbiomed.2023.07.017. PMID: 37487450
Cross-sectional association between severe periodontitis and diabetes mellitus: a nation-wide cohort study. Montero E, Bujaldón R, Montanya E, Calle-Pascual A, Rojo-Martínez G, Castaño L, Franch-Nadal J, Delgado E, Chaves F, Alonso B, Sanz M, Herrera D. Journal of Clinical Periodontology. 2023 Dec 23. doi: 10.1111/jcpe.13937. PMID: 38140803
Dynamics of Human Anelloviruses in plasma and clinical outcomes following kidney transplantation. Forque L, Fernandez-Ruiz M, Albert E, Gimenez E, Monzo C, Chaves J, Redondo N, Rodriguez-Goncer I, Ruiz-Merlo T, Parra P, Andres A, Aguado JM, Navarro D. Transplantation. 2023 Feb 1;107(2):511-520. doi: 10.1097/TP.0000000000004292. PMID: 36042550
Genetic interaction in the association between oxidative stress and diabetes in the Spanish population. Melero R, Quiroz-Rodriguez M, Lara-Hernandez F, Redon J, Saez G, Briongos-Figuero L, Abadia-Otero J, Martin-Escudero J, Chaves F, Ayala G, Garcia-Garcia A. Free Radical Biology & Medicine. 2023 Jun 1;205:62-68. doi: 10.1016/j.freeradbiomed.2023.05.030. PMID: 37268047
Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study). Valdes S, Doulatram-Gamgaram V, Maldonado-Araque C, Lago-Sampedro A, Garcia-Escobar E, Garcia-Serrano S, Garcia-Vivanco M, Juan L, Theobald M, Gil V, Martin-Llorente F, Ocon P, Calle-Pascual A, Castano L, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves F, Galan-Garcia J, Aguilera-Venegas G, Gutierrez-Repiso C, Fernandez-Garcia J, Colomo N, Soriguer F, Garcia-Fuentes E, Rojo-Martinez G. Environmental Health. 2022 Aug 17;21(1):76. doi: 10.1186/s12940-022-00889-1. PMID: 35978396
An all-in-one point-of-care testing device for multiplexed detection of respiratory infections. Teixeira W, Pallas-Tamarit Y, Juste-Dolz A, Sena-Torralba A, Gozalbo-Rovira R, Rodriguez-Diaz J, Navarro D, Carrascosa J, Gimenez-Romero D, Maquieira A, Morais S. Biosensors & Bioelectronics. 2022 Jun 8;213:114454. doi: 10.1016/j.bios.2022.114454. PMID: 35696866
Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega Follow-up Study. Usategui-Martin R, Perez-Castrillon J, Mansego M, Lara-Hernandez F, Manzano I, Briongos L, Abadia-Otero J, Martin-Vallejo J, Garcia-Garcia A, Martin-Escudero J, Chaves F. Gene. 2022 Jan 30;809:146036. doi: 10.1016/j.gene.2021.146036. PMID: 34688818
Combined kinetic analysis of SARS-CoV-2 RNAemia, N-antigenemia and virus-specific antibodies in critically ill adult COVID-19 patients. Costa R, Alberola J, Olea B, Gozalbo-Rovira R, Gimenez E, Cuevas-Ferrando E, Torres I, Albert E, Carbonell N, Ferreres J, Sanchez G, Rodriguez-Diaz J, Blasco M, Navarro D. Scientific Reports. 2022 May 18;12(1):8273. doi: 10.1038/s41598-022-12461-5. PMID: 35585163
Association between long term exposure to particulate matter and incident hypertension in Spain. Doulatram-Gamgaram V, Valdes S, Maldonado-Araque C, Lago-Sampedro A, Badia-Guillen R, Garcia-Escobar E, Garcia-Serrano S, Garcia-Vivanco M, Garrido JL, Theobald MR, Gil V, Martin-Llorente F, Calle-Pascual A, Bordiu E, Castano L, Delgado E, Franch-Nadal J, Chaves FJ, Montanya E, Galan-Garcia JL, Aguilera-Venegas G, Soriguer F, Rojo-Martinez G. Scientific Reports. 2021 Oct 5;11(1):19702. doi: 10.1038/s41598-021-99154-7. PMID: 34611240
Benchmarking different approaches for Norovirus genome assembly in metagenome samples. Fuentes-Trillo A, Monzo C, Manzano I, Santiso-Bellon C, da Silva Ribeiro de Andrade J, Gozalbo-Rovira R, Garcia-Garcia AB, Rodriguez-Diaz J, Chaves FJ. BMC Genomics. 2021 Nov 24;22(1):849. doi: 10.1186/s12864-021-08067-2. PMID: 34819031
Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2021 Aug;93(8):5167-5172. doi: 10.1002/jmv.26661. PMID: 33174620
Epidemiological and Genetic Characterization of Sapovirus in Patients with Acute Gastroenteritis in Valencia (Spain). de Oliveira-Tozetto S, Santiso-Bellon C, Ferrer-Chirivella J, Navarro-Lleo N, Vila-Vicent S, Rodriguez-Diaz J, Buesa J. Viruses. 2021 Jan 26;13(2):184. doi: 10.3390/v13020184. PMID: 33530573
Projects
Title: Role of host mucosal glycosylation in SARS-CoV-2 infectivity
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2022 – 2024
Total budget: 90.000 €
Title: Estudio multifactorial para la identificación de nuevos factores genéticos y no genéticos mediante la secuenciación del exoma y técnicas de inteligencia artificial
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2022 – 2024
Total budget: 183.920 €
Title: ImpactT2D: una estrategia genómica para implementar medicina de precisión en la diabetes tipo 2
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2022 – 2025
Total budget: 106.700 €
Title: Glicosil hidrolasas bacterianas y su función en la infectividad viral
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2021 – 2024
Total budget: 160.930 €
Title: Desarrollo de un sistema rápido y económico para la detección de patógenos causantes de gastroenteritis infecciosas mediante EOSAL
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2020 – 2021
Total budget: 40000
Title: Detección y caracterización rápida de COVID19 y del paciente
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2020 – 2021
Total budget: 175.000 €
Title: Creació d’una infraestructura de producció, purificació i caracterització de proteïnes d’interés biomèdic i biotecnològic
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2018 – 2020
Total budget: 431.414 €
Title: Identificación de variantes genéticas protectoras frente al desarrollo de diabetes tipo 2 en octogenarios
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2018 – 2021
Total budget: 196.020 €
Title: Descifrando las interacciones entre la microbiota intestinal/virus entéricos/hospedador: bases para proteger frente a la diarrea viral
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2018 – 2021
Total budget: 133.100 €
+ Info
Starting year: 2013
Researchers: Chaves Martínez, Felipe Javier
Web: https://www.seqplexing.com/
Doctoral candidate: Fuentes Trillo, Azahara Maria
Director(s): Chaves Martínez, Felipe Javier; Navarro Cubells, Blanca; Terol Casterá, María José
Date of the defense: 10/03/2023
University: Universitat de València
Title: Mgviz: desarrollo e integración de métodos de análisis y visualización de datos genómicos en biomedicina
Doctoral candidate: Juanes Tebar, Jose Miguel
Director(s): Chaves Martínez, Felipe Javier; Marín García, Pablo; Arnau Llombart, Vicente
Date of the defense: 22/03/2021
University: Universitat de València
Title: Aproximaciones moleculares al estudio de las interacciones de rotavirus y norovirus con el huésped
Doctoral candidate: Vila Vicent, Susana
Director(s): Rodríguez Díaz, Jesús; Buesa Gómez, Francisco Javier
Date of the defense: 05/11/2020
University: Universitat de València
Title: Identificación de variantes genéticas relacionadas con diabetes mellitus tipo 2 en población española
Doctoral candidate: Lendínez Tortajada, Verónica
Director(s): Chaves Martínez, Felipe Javier; Real Collado, Jose Tomás
Date of the defense: 31/01/2020
University: Universitat de València
Title: Exome sequencing in gastrointestinal food allergy induced by multiple food protein
Doctoral candidate: Sanchis Juan, Alba
Director(s): Chaves Martínez, Felipe Javier; Marín García, Pablo; García García, Ana-Bárbara; Gadea Vacas, José
Date of the defense: 10/12/2019
University: Universitat Politècnica de València