Genomics and Diabetes Unit

Cardiovascular Area

Identify genetic and environmental factors involved in the development of type 2 diabetes and related diseases

Identify alterations of methylation and hydroxymethylation in relation to the development of type 2 diabetes and its potential use as biomarkers

Identify genetic causes of rare diseases: Abeta, ATA and hereditary forms of hypercholesterolemias not caused by known genes

Study of environmental factors involved in the development of diseases of high cardiovascular risk, especially type 2 diabetes and associated organic damage

Development of fast and easy procedures for SARS-CoV2 (COVID19) detection and characterization (including the analysis of the main human genetic variations involved in COVID19)

Coordinator
Dr. Felipe Javier Chaves Martínez
felipe.chaves@uv.es
RESEARCHERS
Leading, R4

Felipe Javier Chaves Martínez    

Established, R3

Jesús Rodríguez Díaz

Recognised/Emerging, R2

Ana Bárbara García García
Roberto Gozalbo Rovira

First Stage, R1

Azahara Mª Fuentes Trillo
Cristina Santiso Bellón
Fran Lara Hernández
Mª Elena Quiroz Rodríguez
Nazaret Peña Gil
Rebeca Melero Valverde
Soraya García Sorribes

STAFF
Collaborating Researchers
Nurse
Technicians
Administrative assistant
Publications

Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega Follow-up Study. Usategui-Martin R, Perez-Castrillon J, Mansego M, Lara-Hernandez F, Manzano I, Briongos L, Abadia-Otero J, Martin-Vallejo J, Garcia-Garcia A, Martin-Escudero J, Chaves F. Gene. 2022 Jan 30;809:146036. doi: 10.1016/j.gene.2021.146036. PMID: 34688818

SARS-CoV-2 N-antigenemia in critically ill adult COVID-19 patients: frequency and association with inflammatory and tissue-damage biomarkers. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Medical Virology. 2022 Jan;94(1):222-228. doi: 10.1002/jmv.27300. PMID: 34449894

Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients. Olea B, Albert E, Torres I, Amat P, Remigia M, Gozalbo-Rovira R, Rodriguez-Diaz J, Buesa J, Blasco M, Redon J, Signes-Costa J, Navarro D. Journal of Clinical Virology. 2021 Sep;142:104943. doi: 10.1016/j.jcv.2021.104943. PMID: 34391981

Association between long term exposure to particulate matter and incident hypertension in Spain. Doulatram-Gamgaram V, Valdes S, Maldonado-Araque C, Lago-Sampedro A, Badia-Guillen R, Garcia-Escobar E, Garcia-Serrano S, Garcia-Vivanco M, Garrido JL, Theobald MR, Gil V, Martin-Llorente F, Calle-Pascual A, Bordiu E, Castano L, Delgado E, Franch-Nadal J, Chaves FJ, Montanya E, Galan-Garcia JL, Aguilera-Venegas G, Soriguer F, Rojo-Martinez G. Scientific Reports. 2021 Oct 5;11(1):19702. doi: 10.1038/s41598-021-99154-7. PMID: 34611240

Benchmarking different approaches for Norovirus genome assembly in metagenome samples. Fuentes-Trillo A, Monzo C, Manzano I, Santiso-Bellon C, da Silva Ribeiro de Andrade J, Gozalbo-Rovira R, Garcia-Garcia AB, Rodriguez-Diaz J, Chaves FJ. BMC Genomics. 2021 Nov 24;22(1):849. doi: 10.1186/s12864-021-08067-2. PMID: 34819031

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2021 Aug;93(8):5167-5172. doi: 10.1002/jmv.26661. PMID: 33174620

Epidemiological and Genetic Characterization of Sapovirus in Patients with Acute Gastroenteritis in Valencia (Spain). de Oliveira-Tozetto S, Santiso-Bellon C, Ferrer-Chirivella J, Navarro-Lleo N, Vila-Vicent S, Rodriguez-Diaz J, Buesa J. Viruses. 2021 Jan 26;13(2):184. doi: 10.3390/v13020184. PMID: 33530573

Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study. Garcia-Escobar E, Valdes S, Soriguer F, Vendrell J, Urrutia-Etxebarria I, Maldonado-Araque C, Ortega E, Ocon P, Montanya E, Menendez E, Lago-Sampedro A, Gonzalez-Frutos T, Gomis R, Goday A, Garcia-Serrano S, Galan-Garcia J, Castell C, Bordiu E, Badia R, Aguilera-Venegas G, Girbes J, Gaztambide S, Delgado E, Chaves F, Castano L, Calle-Pascual A, Rojo-Martinez G, Franch-Nadal J. Scientific Reports. 2021 Aug 12;11(1):16453. doi: 10.1038/s41598-021-95546-x. PMID: 34385479

Infant gut microbiota modulation by human milk disaccharides in humanized microbiome mice. Rubio-Del-Campo A, Gozalbo-Rovira R, Moya-Gonzalvez E, Alberola J, Rodriguez-Diaz J, Yebra M. Gut Microbes. 2021 Jan-Dec;13(1):1-20. doi: 10.1080/19490976.2021.1914377. PMID: 33938391

Inference of SARS-CoV-2 spike-binding neutralizing antibody titers in sera from hospitalized COVID-19 patients by using commercial enzyme and chemiluminescent immunoassays. Valdivia A, Torres I, Latorre V, Frances-Gomez C, Albert E, Gozalbo-Rovira R, Alcaraz M, Buesa J, Rodriguez-Diaz J, Geller R, Navarro D. European Journal of Clinical Microbiology & Infectious Diseases. 2021 Mar;40(3):485-494. doi: 10.1007/s10096-020-04128-8. PMID: 33404891

Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children. Gozalbo-Rovira R, Rubio-Del-Campo A, Santiso-Bellon C, Vila-Vicent S, Buesa J, Delgado S, Molinero N, Margolles A, Yebra M, Collado M, Monedero V, Rodriguez-Diaz J. International Journal of Molecular Sciences. 2021 Jan 20;22(3):1010. doi: 10.3390/ijms22031010. PMID: 33498321

Iodine Deficiency and Mortality in Spanish Adults. Di@bet.es study. Maldonado-Araque C, Valdes S, Badia-Guillen R, Lago-Sampedro A, Colomo N, Garcia-Fuentes E, Gutierrez-Repiso C, Goday-Arno A, Calle-Pascual A, Castano L, Castell C, Delgado Alvarez E, Menendez Torre E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves Martínez F, Soriguer F, Rojo-Martinez G. Thyroid. 2021 Jan;31(1):106-114. doi: 10.1089/thy.2020.0131. PMID: 32781944

Lower respiratory tract and plasma SARS-CoV-2 RNA load in critically ill adult COVID-19 patients: Relationship with biomarkers of disease severity. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Infection. 2021 Sep;83(3):381-412. doi: 10.1016/j.jinf.2021.05.036. PMID: 34087349

Microbiota depletion promotes human rotavirus replication in an adult mouse model. Gozalbo-Rovira R, Santiso-Bellon C, Buesa J, Rubio-del-Campo A, Vila-Vicent S, Munoz C, Yebra M, Monedero V, Rodriguez-Diaz J. Biomedicines. 2021 Jul 20;9(7):846. doi: 10.3390/biomedicines9070846. PMID: 34356911

Suitability of Two Rapid Lateral Flow Immunochromatographic Assays for Predicting SARS-CoV-2 Neutralizing Activity of Sera. Valdivia A, Torres I, Latorre V, Frances-Gomez C, Ferrer J, Forque L, Costa R, de la Asuncion C, Huntley D, Gozalbo-Rovira R, Buesa J, Gimenez E, Rodriguez-Diaz J, Geller R, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):2301-2306. doi: 10.1002/jmv.26697. PMID: 33236799

The Rotavirus Vaccine Landscape, an Update. Carcamo-Calvo R, Munoz C, Buesa J, Rodriguez-Diaz J, Gozalbo-Rovira R. Pathogens. 2021 Apr 26;10(5):520. doi: 10.3390/pathogens10050520. PMID: 33925924

Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study. Alonso SP, Valdes S, Maldonado-Araque C, Lago A, Ocon P, Calle A, Castano L, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves F, Garcia-Serrano S, Garcia-Escobar E, Fernandez-Garcia JC, Olveira G, Colomo N, Rojo-Martinez G. European Journal of Endocrinology. 2021 Dec 1;186(1):95-103. doi: 10.1530/EJE-21-0640. PMID: 34735370

Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis. Perez Hernandez J, Martínez Arroyo O, Ortega Gutiérrez A, Galera Martos M, Solis Salguero M, Chaves Martínez F, Redón Mas J, Forner Giner M, Cortés Vergaz R. Journal Of Nephrology. 2021 Aug;34(4):1157-1167. doi: 10.1007/s40620-020-00832-y. PMID: 32803682

Urinary- and Plasma-Derived Exosomes Reveal a Distinct MicroRNA Signature Associated With Albuminuria in Hypertension. Perez-Hernandez J, Riffo-Campos A, Ortega A, Martinez-Arroyo O, Perez-Gil D, Olivares D, Solaz E, Martinez F, Martinez-Hervas S, Chaves F, Redon J, Cortes R. Hypertension. 2021 Mar 3;77(3):960-971. doi: 10.1161/HYPERTENSIONAHA.120.16598. PMID: 33486986

Easy One-Step Amplification and Labeling Procedure for Copy Number Variation Detection. Blesa Luján S, Olivares Gazquez M, Alic A, Serrano Alcalá A, Lendinez Tortajada V, Gonzalez Albert V, Olivares Ordoñez L, Martinez Hervas S, Juanes Tébar J, Marin P, Real Collado J, Navarro Cubells B, García García A, Chaves Martínez F, Ivorra C. Clinical Chemistry. 2020 Mar 1;66(3):463-473. doi: 10.1093/clinchem/hvaa002. PMID: 32068788

Epidemiological Surveillance of Norovirus and Rotavirus in Sewage (2016-2017) in Valencia (Spain). Santiso-Bellon C, Randazzo W, Perez-Cataluna A, Vila-Vicent S, Gozalbo-Rovira R, Munoz C, Buesa Gomez J, Sanchez G, Rodriguez Diaz J. Microorganisms. 2020 Mar 24;8(3):458. doi: 10.3390/microorganisms8030458. PMID: 32213877

Erratum: Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly. Corrigendum. Casino P, Gozalbo-Rovira R, Rodríguez-Díaz J, Banerjee S, Boutaud A, Rubio V, Hudson BG, Saus J, Cervera J, Marina A. IUCrJ. 2020 Jun 13;7(Pt 4):777. doi: 10.1107/S2052252520007216. PMID: 32695424

Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota. Rubio-Del-Campo A, Alcántara C, Collado MC, Rodríguez-Díaz J, Yebra MJ. Scientific Reports. 2020 Jul 16;10(1):11845. doi: 10.1038/s41598-020-68718-4. PMID: 32678209

Impact of clinical features, cytogenetics, genetic mutations, and methylation dynamics of CDKN2B and DLC-1 promoters on treatment response to azacitidine. Martin Gonzalez I, Navarro Cubells B, Serrano Alcalá A, Villamón Ribate E, Calabuig Muñoz M, Solano Vercet C, Chaves Martínez F, Yague N, Orts M, Amat Martínez P, Fuentes Trillo A, Seda García E, García García F, Hernandez Boluda J, Tormo Diaz M. Annals of Hematology. 2020 Mar;99(3):527-537. doi: 10.1007/s00277-020-03932-8. PMID: 31989250

Incidence and regression of metabolic syndrome in a representative sample of the Spanish population: results of the cohort di@bet.es study. Cuesta M, Fuentes M, Rubio M, Bordiu E, Barabash A, Garcia de la Torre N, Rojo-Martinez G, Valdes S, Soriguer F, Vendrell J, Urrutia I, Ortega E, Montanya E, Menendez E, Lago-Sampedro A, Gomis R, Goday A, Castell C, Badia-Guillen R, Girbes J, Gaztambide S, Franch-Nadal J, Delgado Alvarez E, Chaves F, Castano L, Calle-Pascual A. BMJ Open Diabetes Research & Care. 2020 Oct;8(1):e001715. doi: 10.1136/bmjdrc-2020-001715. PMID: 33051280

Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study. Rojo-Martinez G, Valdes S, Soriguer F, Vendrell J, Urrutia I, Perez V, Ortega E, Ocon P, Montanya E, Menendez E, Lago-Sampedro A, Gonzalez-Frutos T, Gomis R, Goday A, Garcia-Serrano S, Garcia-Escobar E, Galan-Garcia J, Castell C, Badia-Guillen R, Aguilera-Venegas G, Girbes J, Gaztambide S, Franch-Nadal J, Delgado E, Chaves Martínez F, Castano L, Calle-Pascual A. Scientific Reports. 2020 Feb 17;10(1):2765. doi: 10.1038/s41598-020-59643-7. PMID: 32066839

Optimization of small RNA library preparation protocol from human urinary exosomes. Olivares Gazquez M, Perez Hernandez J, Perez Gil D, Chaves Martínez F, Redón Mas J, Cortés Vergaz R. Journal of Translational Medicine. 2020 Mar 18;18(1):132. doi: 10.1186/s12967-020-02298-9. PMID: 32188466

Polymorphisms in genes involved in inflammation, the NF-kB pathway and the renin-angiotensin-aldosterone system are associated with the risk of osteoporotic fracture. The Hortega Follow-up Study. Usategui-Martin R, Lendinez Tortajada V, Perez-Castrillon J, Briongos-Figuero L, Abadia-Otero J, Martin-Vallejo J, Lara Hernández F, Chaves Martínez F, García García A, Martin-Escudero J. BONE. 2020 Sep;138:115477. doi: 10.1016/j.bone.2020.115477. PMID: 32535289

Rab-rabphilin system in injured human podocytes stressed by glucose overload and angiotensin II. Martínez Arroyo O, Ortega Gutiérrez A, Perez Hernandez J, Chaves Martínez F, Redón Mas J, Cortés Vergaz R. American Journal of Physiology. Renal Physiology. 2020 Aug 1;319(2):F178-F191. doi: 10.1152/ajprenal.00077.2020. PMID: 32567349

Recommendations for the introduction of metagenomic high-throughput sequencing in clinical virology, part I: Wet lab procedure. Lopez-Labrador F, Brown J, Fischer N, Harvala H, Van Boheemen S, Cinek O, Sayiner A, Madsen T, Auvinen E, Kufner V, Huber M, Rodriguez C, Jonges M, Honemann M, Susi P, Sousa H, Klapper P, Perez-Cataluna A, Hernandez M, Molenkamp R, der Hoek L, Schuurman R, Couto N, Leuzinger K, Simmonds P, Beer M, Hoper D, Kamminga S, Feltkamp M, Rodriguez-Diaz J, Keyaerts E, Nielsen X, Puchhammer-Stockl E, Kroes A, Buesa J, Breuer J, Claas E, de Vries J, ESCV Network on Next-Generation Sequencing. Journal of Clinical Virology. 2020 Nov 18;134:104691. doi: 10.1016/j.jcv.2020.104691. PMID: 33278791

SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patients. Gozalbo-Rovira R, Gimenez Quiles E, Latorre V, Frances-Gomez C, Albert Vicent E, Buesa Gomez J, Marina A, Blasco Cortes M, Signes-Costa Miñana J, Rodriguez Diaz J, Geller R, Navarro Ortega D. Journal of Clinical Virology. 2020 Oct;131:104611. doi: 10.1016/j.jcv.2020.104611. PMID: 32882666

Sero-epidemiological study of the rotavirus VP8 protein from different P genotypes in Valencia, Spain. Vila Vicent S, Gozalbo-Rovira R, Rubio Del Campo A, Santiso Bellon C, Navarro-Lleo N, Munoz C, Buesa Gomez J, Rodriguez Diaz J. Scientific Reports. 2020 May 8;10(1):7753. doi: 10.1038/s41598-020-64767-x. PMID: 32385405

Srebf2 Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets. Andres-Blasco I, Blesa S, Vinue A, Gonzalez-Navarro H, Real J, Martinez-Hervas S, Carretero J, Ferrandez-Izquierdo A, Chaves F, Garcia-Garcia A. Nutrients. 2020 Oct 14;12(10):3130. doi: 10.3390/nu12103130. PMID: 33066385

Unique Microbial Catabolic Pathway for the Human Core N-Glycan Constituent Fucosyl-alpha-1,6-N-Acetylglucosamine-Asparagine. Becerra J, Rodriguez Diaz J, Gozalbo-Rovira R, Palomino-Schatzlein M, Zuniga M, Monedero V, Yebra M. mBio. 2020 Jan 14;11(1):e02804-19. doi: 10.1128/mBio.02804-19. PMID: 31937642

Projects

Referencia: PI21/00506
Título: Estudio multifactorial para la identificación de nuevos factores genéticos y no genéticos mediante la secuenciación del exoma y técnicas de inteligencia artificial
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Felipe Javier Chaves Martínez
Duración: 2022 – 2024
Presupuesto: 183.920 €

Referencia: PMP21/00076
Título: ImpactT2D: una estrategia genómica para implementar medicina de precisión en la diabetes tipo 2
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Felipe Javier Chaves Martínez
Duración: 2022 – 2025
Presupuesto: 106.700 €

Referencia: AEST/2020/041
Título: Desarrollo de un sistema rápido y económico para la detección de patógenos causantes de gastroenteritis infecciosas mediante EOSAL
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Jesús Rodríguez Díaz
Duración: 2020 – 2021
Presupuesto: 40000

Referencia: COV20/00279
Título: Detección y caracterización rápida de COVID19 y del paciente
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Felipe Javier Chaves Martínez
Duración: 2020 – 2021
Presupuesto: 175.000 €

Referencia: IDIFEDER/2018/056
Título: Creació d’una infraestructura de producció, purificació i caracterització de proteïnes d’interés biomèdic i biotecnològic
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Jesús Rodríguez Díaz
Duración: 2018 – 2020
Presupuesto: 431.414 €

Referencia: PI17/00544
Título: Identificación de variantes genéticas protectoras frente al desarrollo de diabetes tipo 2 en octogenarios
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Felipe Javier Chaves Martínez
Duración: 2018 – 2021
Presupuesto: 196.020 €

Referencia: AGL2017-84165-C2-2-R
Título: Descifrando las interacciones entre la microbiota intestinal/virus entéricos/hospedador: bases para proteger frente a la diarrea viral
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Jesús Rodríguez Díaz
Duración: 2018 – 2021
Presupuesto: 133.100 €

+ Information

Título: Mgviz: desarrollo e integración de métodos de análisis y visualización de datos genómicos en biomedicina
Doctorando: Juanes Tebar, Jose Miguel
Director: Chaves Martínez, Felipe Javier; Marín García, Pablo; Arnau Llombart, Vicente
Fecha: 22/03/2021
Universidad: Universitat de València

Título: Aproximaciones moleculares al estudio de las interacciones de rotavirus y norovirus con el huésped
Doctorando: Vila Vicent, Susana
Director: Rodríguez Díaz, Jesús; Buesa Gómez, Francisco Javier
Fecha: 05/11/2020
Universidad: Universitat de València

Título: Identificación de variantes genéticas relacionadas con diabetes mellitus tipo 2 en población española
Doctorando: Lendínez Tortajada, Verónica
Director: Chaves Martínez, Felipe Javier; Real Collado, Jose Tomás
Fecha: 31/01/2020
Universidad: Universitat de València

Título: Exome sequencing in gastrointestinal food allergy induced by multiple food protein
Doctorando: Sanchis Juan, Alba
Director: Chaves Martínez, Felipe Javier; Marín García, Pablo; García García, Ana-Bárbara; Gadea Vacas, José
Fecha: 10/12/2019
Universidad: Universitat Politècnica de València