Dr. Rafael Tabarés Seisdedos

Principal Investigator
Research Group on Personal Autonomy, Dependence and Severe Mental Disorders (TMAP)

Presentation


El Profesor Tabarés es Catedrático de Psiquiatría de la Universitat de València, Investigador Principal en el Centro de Investigaciones Biomédicas en Red de Salud Mental (CIBERSAM) del Ministerio de Ciencia e Innovación, y de uno de los grupos de Excelencia del programa PROMETEO, Director del Grupo de Investigación en Trastornos Mentales Graves de la Universitat de València y Coordinador del microcluster de “Autonomía Personal, Dependencia y Trastornos Mentales Graves, MCI” dentro del Campus de Excelencia VLC/CAMPUS del Ministerio de Ciencia e Innovación constituido en Unidad de investigación, miembro del Comité Científico de Expertos del Ministerio de Sanidad y Política Social-IMSERSO para la aplicación del Centro de Referencia de Atención socio-sanitaria para Personas con Trastorno Mental Grave en Valencia. Miembro del comité editorial y de expertos de varias revistas de prestigio, ha obtenido múltiples premios y reconocimientos, destacando entre ellos:

– Formar parte del listado de investigadores altamente citados (indicador HiCi; Thomson-Reuters, 2013). Listado conjunto de todas las áreas de conocimiento compuesto por 112 Investigadores altamente citados en España, de los cuales, cinco de ellos corresponden a la Universitat de València.

– The Aristotles Reserch Award al estudio: Mutations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar disorder: A preliminary study. 2nd International congress on BRAIN AND BEHAVIOUR, at the Grand HotelPalace, Thessaloniki, Greece. 2005

– Premio Investigador de Referencia dentro del Programa de Excelencia Investigadora de la Sociedad Española de Psiquiatría Biológica. IIIX Congreso Nacional de Psiquiatría. Madrid 2009

– Premio de la Real Academia de Medicina y Ciencias Afines de la Comunitat Valenciana 2013 a la mejor investigación científica por el trabajo de investigación titulado: “Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50 Observational Studies”.

Dr. Rafael Tabarés Seisdedos
Principal
Investigator
Dr. Rafael Tabarés Seisdedos

rafael.tabares@uv.es

Publications
A cross-sectional analysis identified co-authorship networks and scientific collaboration on reporting guidelines for health research. Catala Lopez F, Alonso Arroyo A, Page MJ, Castello Cogollos L, Hutton B, Ridao M, Tabares Seisdedos R, Aleixandre Benavent R, Moher D. Journal of Clinical Epidemiology. 2023 Feb 22;157:22-34. doi: 10.1016/j.jclinepi.2023.02.001. PMID: 36822440

Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026. Global Burden of Disease 2021 Health Financing Collaborator Network. Lancet. Global Health. 2023 Mar;11(3):e385-e413. doi: 10.1016/S2214-109X(23)00007-4. PMID: 36706770

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. GBD 2021 Diabetes Collaborators. Lancet. 2023 Jul 15;402(10397):203-234. doi: 10.1016/S0140-6736(23)01301-6. PMID: 37356446

Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019. Wu D, Jin Y, Xing Y, et al. Eclinicalmedicine. 2023 Sep 9:64:102193. doi: 10.1016/j.eclinm.2023.102193. PMID: 37731935

Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019. GBD 2019 Europe Hepatitis B & C Collaborators. Lancet. Public Health. 2023 Sep;8(9):e701-e716. doi: 10.1016/S2468-2667(23)00149-4. PMID: 37633679

Inflammation and lipid metabolism as potential biomarkers of memory impairment across type 2 diabetes mellitus and severe mental disorders. Sanchez-Orti J, Correa-Ghisays P, Balanza-Martinez V, Selva-Vera G, Vila-Frances J, Magdalena-Benedito R, San-Martin C, Victor V, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, Crespo-Facorro B, Tabares-Seisdedos R. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2023 Jun 15;127:110817. doi: 10.1016/j.pnpbp.2023.110817. PMID: 37327846

Myopericarditis associated with the novavax COVID-19 Vaccine (NVX-CoV2373): a retrospective analysis of individual case safety reports from VigiBase. Macias Saint-Gerons D, Ibarz M, Castro J, Fores-Martos J, Tabares-Seisdedos R. Drugs – Real World Outcomes. 2023 Jun;10(2):263-270. doi: 10.1007/s40801-023-00355-5. PMID: 36788170

A cofactor-based mechanism for the origin of the genetic code. Martinez Gimenez J, Tabares Seisdedos R. Origins of Life and Evolution of Biospheres. 2022 Sep;52(1-3):149-163. doi: 10.1007/s11084-022-09628-5. PMID: 36071304

A GBD 2019 study of health and sustainable development goal gains and forecasts to 2030 in Spain. Lazarus J, Ortiz A, Tyrovolas S, Fernandez E, Guy D, White T, Ma R, Hay S, Naghavi M, Soriano J. Scientific Reports. 2022 Dec 7;12(1):21154. doi: 10.1038/s41598-022-24719-z. PMID: 36477107

Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019. Peden A, Cullen P, Francis K, et al. Lancet Public Health. 2022 Aug;7(8):e657-e669. doi: 10.1016/S2468-2667(22)00134-7. PMID: 35779567

Arsenic exposure, blood DNA methylation, and cardiovascular disease. Domingo-Relloso A, Makhani K, Riffo-Campos A, Tellez-Plaza M, Klein K, Subedi P, Zhao J, Moon K, Bozack A, Haack K, Goessler W, Umans J, Best L, Zhang Y, Herreros-Martinez M, Glabonjat R, Schilling K, Galvez-Fernandez M, Kent J, Sanchez T, Taylor K, Craig Johnson W, Durda P, Tracy R, Rotter J, Rich S, Van Den Berg D, Kasela S, Lappalainen T, Vasan R, Joehanes R, Howard B, Levy D, Lohman K, Liu Y, Daniele Fallin M, Cole S, Mann K, Navas-Acien A. Circulation Research. 2022 Jul 8;131(2):e51-e69. doi: 10.1161/CIRCRESAHA.122.320991. PMID: 35658476

Assessing performance of the healthcare access and quality index, overall and by select age groups, for 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. Haakenstad A, Yearwood J, Fullman N, et al. Lancet. Global Health. 2022 Dec;10(12):e1715-e1743. doi: 10.1016/S2214-109X(22)00429-6. PMID: 36209761

Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019. Armocida B, Monasta L, Sawyer S, Bustreo F, Segafredo G, Castelpietra G, Ronfani L, Pasovic M, Hay S, Perel P, Beran D. Lancet Child & Adolescent Health. 2022 Jun;6(6):367-383. doi: 10.1016/S2352-4642(22)00073-6. PMID: 35339209

Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019 a systematic analysis for the Global Burden of Disease Study 2019. Kocarnik J, Compton K, Dean F, et al. JAMA Oncology. 2022 Mar 1;8(3):420-444. doi: 10.1001/jamaoncol.2021.6987. PMID: 34967848

Design and methodological characteristics of studies using observational routinely collected health data for investigating the link between cancer and neurodegenerative diseases: protocol for a meta-research study. Catala-Lopez F, Driver J, Page M, Hutton B, Ridao M, Berrozpe-Villabona C, Alonso-Arroyo A, Fraga-Medin C, Bernal-Delgado E, Valencia A, Tabares-Seisdedos R. BMJ Open. 2022 Apr 29;12(4):e058738. doi: 10.1136/bmjopen-2021-058738. PMID: 35487732

Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019. Cousin E, Duncan B, Stein C, et al. Lancet Diabetes & Endocrinology. 2022 Mar;10(3):177-192. doi: 10.1016/S2213-8587(21)00349-1. PMID: 35143780

Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2.5 air pollution, 1990-2019: an analysis of data from the Global Burden of Disease Study 2019. GBD 2019 Diabetes and Air Pollution Collaborators. Lancet Planetary Health. 2022 Jul;6(7):e586-e600. doi: 10.1016/S2542-5196(22)00122-X. PMID: 35809588

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease 2019. Nichols E, Steinmetz J, Vollset S, et al. Lancet Public Health. 2022 Feb;7(2):e105-e125. doi: 10.1016/S2468-2667(21)00249-8. PMID: 34998485

Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study. GBD 2019 Ageing Collaborators. BMJ-British Medical Journal. 2022 Mar 10;376:e068208. doi: 10.1136/bmj-2021-068208. PMID: 35273014

Immune-inflammatory biomarkers predict cognition and social functioning in patients with Type 2 Diabetes Mellitus, major depressive disorder, bipolar disorder, and schizophrenia: a 1-year follow-up study. Gares-Caballer M, Sanchez-Orti J, Correa-Ghisays P, Balanza-Martinez V, Selva-Vera G, Vila-Frances J, Magdalena-Benedito R, San-Martin C, Victor V, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, Vieta E, Leza J, Tabares-Seisdedos R. Frontiers in Neurology. 2022 Jun 2;13:883927. doi: 10.3389/fneur.2022.883927. PMID: 35720107

Mapping development and health effects of cooking with solid fuels in low-income and middle-income countries, 2000-18: a geospatial modelling study. Local Burden of Disease Household Air Pollution Collaborators. Lancet. Global health. 2022 Oct;10(10):e1395-e1411. doi: 10.1016/S2214-109X(22)00332-1. PMID: 36113526

MICEmi: a method to identify cognitive endophenotypes of mental illnesses. Correa-Ghisays P, Vicent Sanchez-Orti J, Balanza-Martinez V, Fuentes-Dura I, Martinez-Aran A, Ruiz-Bolo L, Correa-Estrada P, Ruiz-Ruiz J, Selva-Vera G, Vila-Frances J, Macias Saint-Gerons D, San-Martin C, Ayesa-Arriola R, Tabares-Seisdedos R. European Psychiatry. 2022 Nov 28;65(1):e85. doi: 10.1192/j.eurpsy.2022.2348. PMID: 36440538

Mortality in persons with autism spectrum disorder or attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Catala-Lopez F, Hutton B, Page M, Driver J, Ridao M, Alonso-Arroyo A, Valencia A, Macias Saint-Gerons D, Tabares-Seisdedos R. JAMA Pediatrics. 2022 Apr 1;176(4):e216401. doi: 10.1001/jamapediatrics.2021.6401. PMID: 35157020

Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020. GBD 2020 Alcohol Collaborators. Lancet. 2022 Jul 16;400(10347):185-235. doi: 10.1016/S0140-6736(22)00847-9. PMID: 35843246

Specific metabolic syndrome components predict cognition and social functioning in people with type 2 diabetes mellitus and severe mental disorders. Sanchez-Orti J, Balanza-Martinez V, Correa-Ghisays P, Selva-Vera G, Vila-Frances J, Magdalena-Benedito R, San-Martin C, Victor V, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, Crespo-Facorro B, Tabares-Seisdedos R. Acta Psychiatrica Scandinavica. 2022 Sep;146(3):215-226. doi: 10.1111/acps.13433. PMID: 35359023

The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study. Haagsma J, Charalampous P, Ariani F, et al. Archives of Public Health. 2022 May 20;80(1):142. doi: 10.1186/s13690-022-00891-6. PMID: 35590340

The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990-2019: Findings from the Global Burden of Disease Study 2019. Castelpietra G, Knudsen A, Agardh E, Armocida B, Beghi M, Iburg K, Logroscino G, Ma R, Starace F, Steel N, Addolorato G, Andrei C, Andrei T, Ayuso-Mateos J, Banach M, Barnighausen T, Barone-Adesi F, Bhagavathula A, Carvalho F, Carvalho M, Chandan J, Chattu V, Couto R, Cruz-Martins N, Dargan P, Deuba K, da Silva D, Fagbamigbe A, Fernandes E, Ferrara P, Fischer F, Gaal P, Gialluisi A, Haagsma J, Haro J, Hasan M, Hasan S, Hostiuc S, Iacoviello L, Iavicoli I, Jamshidi E, Jonas J, Joo T, Jozwiak J, Katikireddi S, Kauppila J, Khan M, Kisa A, Kisa S, Kivimaki M, Koly K, Koyanagi A, Kumar M, Lallukka T, Langguth B, Ledda C, Lee P, Lega I, Linehan C, Loureiro J, Madureira-Carvalho A, Martinez-Raga J, Mathur M, McGrath J, Mechili E, Mentis A, Mestrovic T, Miazgowski B, Mirica A, Mirijello A, Moazen B, Mohammed S, Mulita F, Nagel G, Negoi I, Negoi R, Nwatah V, Padron-Monedero A, Panda-Jonas S, Pardhan S, Pasovic M, Patel J, Petcu I, Pinheiro M, Pollok R, Postma M, Rawaf D, Rawaf S, Romero-Rodriguez E, Ronfani L, Sagoe D, Sanmarchi F, Schaub M, Sharew N, Shiri R, Shokraneh F, Sigfusdottir I, Silva J, Silva R, Socea B, Szocska M, Tabares-Seisdedos R, Torrado M, Tovani-Palone M, Vasankari T, Veroux M, Viner R, Werdecker A, Winkler A, Hay S, Ferrari A, Naghavi M, Allebeck P, Monasta L. Lancet Regional Health-Europe. 2022 Apr 1;16:100341. doi: 10.1016/j.lanepe.2022.100341. PMID: 35392452

The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019. GBD 2019 Adolescent Young Adult Cancer Collaborators. The Lancet. Oncology. 2022 Jan;23(1):27-52. doi: 10.1016/S1470-2045(21)00581-7. PMID: 34871551

The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019. GBD 2019 Cancer Risk Factors Collaborators. Lancet. 2022 Aug 20;400(10352):563-591. doi: 10.1016/S0140-6736(22)01438-6. PMID: 35988567

Transdiagnostic neurocognitive deficits in patients with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia: a 1-year follow-up study. Correa-Ghisays P, Sanchez-Orti JV, Balanza-Martinez V, Selva-Vera G, Vila-Frances J, Magdalena-Benedito R, Victor VM, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, San-Martin C, Crespo-Facorro B, Tabares-Seisdedos R. Journal of Affective Disorders. 2022 Mar 1;300:99-108. doi: 10.1016/j.jad.2021.12.074. PMID: 34965401

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018. Kinyoki D, Osgood-Zimmerman A, Bhattacharjee N, Kassebaum N, Hay S, Local Burden Dis Anaemia Collab. Nature Medicine. 2021 Oct;27(10):1761-1782. doi: 10.1038/s41591-021-01498-0. PMID: 34642490

Circadian PERformance in breast cancer: a germline and somatic genetic study of PER3VNTR polymorphisms and gene co-expression. Fores-Martos J, Cervera-Vidal R, Sierra-Roca J, Lozano-Asencio C, Fedele V, Cornelissen S, Edvarsen H, Tadeo-Cervera I, Eroles P, Lluch A, Tabares-Seisdedos R, Falco A, Van’t Veer LJ, Schmidt M, Quigley DA, Borresen-Dale AL, Kristensen VN, Balmain A, Climent J. NPJ Breast Cancer. 2021 Sep 10;7(1):118. doi: 10.1038/s41523-021-00329-2. PMID: 34508103

Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. GBD 2019 Resp Tract Canc Collab. Lancet Respiratory Medicine. 2021 Sep;9(9):1030-1049. doi: 10.1016/S2213-2600(21)00164-8. PMID: 34411511

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019. GBD 2019 Under-5 Mortality Collaborators. Lancet. 2021 Sep 4;398(10303):870-905. doi: 10.1016/S0140-6736(21)01207-1. PMID: 34416195

Is processing speed a valid neurocognitive endophenotype in bipolar disorder? Evidence from a longitudinal, family study. Luperdi SC, Correa-Ghisays P, Vila-Frances J, Selva-Vera G, Salazar-Fraile J, Cardoner N, Ruiz-Veguilla M, Livianos L, Tabares-Seisdedos R, Balanza-Martinez. Journal of Psychiatric Research. 2021 Jul 6;141:241-247. doi: 10.1016/j.jpsychires.2021.07.008. PMID: 34256275

Lifestyle changes and mental health during the COVID-19 pandemic: a repeated, cross-sectional web survey. Cervera-Martinez J, Atienza-Carbonell B, Mota JC, Bobes-Bascaran T, Crespo-Facorro B, Esteban C, Garcia-Portilla MP, Gomes-da-Costa S, Gonzalez-Pinto A, Jaen-Moreno MJ, Sarramea F, Vieta E, Zorrilla I, Tabares-Seisdedos R, Kapczinski F, De Boni RB, Balanza-Martinez V. Journal of Affective Disorders. 2021 Aug 24;295:173-182. doi: 10.1016/j.jad.2021.08.020. PMID: 34469856

Lifestyle in undergraduate students and demographically matched controls during the COVID-19 pandemic in Spain. Giner-Murillo M, Atienza-Carbonell B, Cervera-Martinez J, Bobes-Bascaran T, Crespo-Facorro B, De Boni R, Esteban C, Garcia-Portilla M, Gomes-da-Costa S, Gonzalez-Pinto A, Jaen-Moreno M, Kapczinski F, Ponce-Mora A, Sarramea F, Tabares-Seisdedos R, Vieta E, Zorrilla I, Balanza-Martinez V. International Journal of Environmental Research and Public Health. 2021 Jul 31;18(15):8133. doi: 10.3390/ijerph18158133. PMID: 34360426

Possible ancestral functions of the genetic and RNA operational precodes and the origin of the genetic system. Martinez-Gimenez J, Tabares-Seisdedos R. Origins of Life and Evolution of Biospheres. 2021 Jun;51(2):167-183. doi: 10.1007/s11084-021-09610-7. PMID: 34097191

Torsade de pointes associated with chloroquine, hydroxychloroquine, and azithromycin: a retrospective analysis of individual case safety reports from VigiBase. Saint-Gerons Macias D, Tabares-Seisdedos R. European Journal of Clinical Pharmacology. 2021 Oct;77(10):1513-1521. doi: 10.1007/s00228-021-03133-w. PMID: 33938974

Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050. Global Burden Dis Hlth Financing. Lancet. 2021 Oct 9;398(10308):1317-1343. doi: 10.1016/S0140-6736(21)01258-7. PMID: 34562388

Transcriptomic and genetic associations between alzheimer’s disease, parkinson’s disease, and cancer. Fores-Martos J, Boullosa C, Rodrigo-Dominguez D, Sanchez-Valle J, Suay-Garcia B, Climent J, Falco A, Valencia A, Puig-Butille J, Puig S, Tabares-Seisdedos R. Cancers. 2021 Jun 15;13(12):2990. doi: 10.3390/cancers13122990. PMID: 34203763

Use of multidimensional item response theory methods for dementia prevalence prediction: an example using the Health and Retirement Survey and the Aging, Demographics, and Memory Study. Nichols E, Abd-Allah F, Abdoli A, et al. BMC Medical Informatics and Decision Making. 2021 Aug 11;21(1):241. doi: 10.1186/s12911-021-01590-y. PMID: 34380485

Projects
Reference: PID2021-129099OB-100
Title: MULTImorbilidad en personas con trastornos del Sistema Nervioso Central: una prioridad para la salud global desde los registros médicos
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Rafael Tabarés Seisdedos
Duration: 2022 – 2024
Total budget: 104.060 €
Reference: PI17/00719
Title: Identificación de biomarcadores epigenéticos periféricos asociados con el déficit neurocognitivo en personas con trastorno bipolar, depresión, esquizofrenia y diabetes tipo 2
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Rafael Tabarés Seisdedos
Duration: 2018 – 2020
Total budget: 105.270 €
Reference: CB07/09/0021
Title: CIBER de Salud Mental (CIBERSAM)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Rafael Tabarés Seisdedos
Duration: 2015 –
Total budget:
+ Info
Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library. Catalá-López F, Alonso-Arroyo A, Page MJ, Hutton B, Ridao M, Tabarés-Seisdedos R, Aleixandre-Benavent R, Moher D. BMJ Open. 2019 Mar 4;9(3):e022769. doi: 10.1136/bmjopen-2018-022769. PMID: 30837245

Title: Epidemiological and molecular associations between central nervous system disorders and cancer
Doctoral candidate: Forés Martos, Jaume
Director(s): Tabarés Seisdedos, Rafael; Catalá López, Ferrán; Climent Bataller Joan
Date of the defense: 21/07/2021
University: Universitat de València