Dr. Rafael Tabarés Seisdedos

Investigador Principal
Grupo de Investigación en Autonomía Personal, Dependencia y Trastornos Mentales Graves

Presentación


El Profesor Tabarés es Catedrático de Psiquiatría de la Universitat de València, Investigador Principal en el Centro de Investigaciones Biomédicas en Red de Salud Mental (CIBERSAM) del Ministerio de Ciencia e Innovación, y de uno de los grupos de Excelencia del programa PROMETEO, Director del Grupo de Investigación en Trastornos Mentales Graves de la Universitat de València y Coordinador del microcluster de “Autonomía Personal, Dependencia y Trastornos Mentales Graves, MCI” dentro del Campus de Excelencia VLC/CAMPUS del Ministerio de Ciencia e Innovación constituido en Unidad de investigación, miembro del Comité Científico de Expertos del Ministerio de Sanidad y Política Social-IMSERSO para la aplicación del Centro de Referencia de Atención socio-sanitaria para Personas con Trastorno Mental Grave en Valencia. Miembro del comité editorial y de expertos de varias revistas de prestigio, ha obtenido múltiples premios y reconocimientos, destacando entre ellos:

– Formar parte del listado de investigadores altamente citados (indicador HiCi; Thomson-Reuters, 2013). Listado conjunto de todas las áreas de conocimiento compuesto por 112 Investigadores altamente citados en España, de los cuales, cinco de ellos corresponden a la Universitat de València.

– The Aristotles Reserch Award al estudio: Mutations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar disorder: A preliminary study. 2nd International congress on BRAIN AND BEHAVIOUR, at the Grand HotelPalace, Thessaloniki, Greece. 2005

– Premio Investigador de Referencia dentro del Programa de Excelencia Investigadora de la Sociedad Española de Psiquiatría Biológica. IIIX Congreso Nacional de Psiquiatría. Madrid 2009

– Premio de la Real Academia de Medicina y Ciencias Afines de la Comunitat Valenciana 2013 a la mejor investigación científica por el trabajo de investigación titulado: “Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50 Observational Studies”.

Investigador
Principal
Dr. Rafael Tabarés Seisdedos

rafael.tabares@uv.es

Publicaciones
Is processing speed a valid neurocognitive endophenotype in bipolar disorder? Evidence from a longitudinal, family study. Luperdi SC, Correa-Ghisays P, Vila-Frances J, Selva-Vera G, Salazar-Fraile J, Cardoner N, Ruiz-Veguilla M, Livianos L, Tabares-Seisdedos R, Balanza-Martinez. Journal of Psychiatric Research. 2021 Jul 6;141:241-247. doi: 10.1016/j.jpsychires.2021.07.008. PMID: 34256275

Lifestyle in undergraduate students and demographically matched controls during the COVID-19 pandemic in Spain. Giner-Murillo M, Atienza-Carbonell B, Cervera-Martinez J, Bobes-Bascaran T, Crespo-Facorro B, De Boni R, Esteban C, Garcia-Portilla M, Gomes-da-Costa S, Gonzalez-Pinto A, Jaen-Moreno M, Kapczinski F, Ponce-Mora A, Sarramea F, Tabares-Seisdedos R, Vieta E, Zorrilla I, Balanza-Martinez V. International Journal of Environmental Research and Public Health. 2021 Jul 31;18(15):8133. doi: 10.3390/ijerph18158133. PMID: 34360426

Torsade de pointes associated with chloroquine, hydroxychloroquine, and azithromycin: a retrospective analysis of individual case safety reports from VigiBase. Saint-Gerons Macias D, Tabares-Seisdedos R. European Journal of Clinical Pharmacology. 2021 May 3;1-9. doi: 10.1007/s00228-021-03133-w. PMID: 33938974

Transcriptomic and genetic associations between alzheimer’s disease, parkinson’s disease, and cancer. Fores-Martos J, Boullosa C, Rodrigo-Dominguez D, Sanchez-Valle J, Suay-Garcia B, Climent J, Falco A, Valencia A, Puig-Butille J, Puig S, Tabares-Seisdedos R. Cancers. 2021 Jun 15;13(12):2990. doi: 10.3390/cancers13122990. PMID: 34203763

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017. LBD Double Burden of Malnutrition Collaborators, Tabarés Seisdedos R, LBD Double Burden of Malnutrition Collaborators. Nature Medicine. 2020 Aug;26(8):1308. doi: 10.1038/s41591-020-0972-7. PMID: 32616917

Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017. Haagsma J, James S, Castle C, et al. Injury prevention. 2020 Oct;26(Supp 1):i12-i26. doi: 10.1136/injuryprev-2019-043296. PMID: 31915273

Childhood trauma and substance use underlying psychosis: a systematic review. Setien-Suero E, Suarez-Pinilla P, Ferro A, TABARÉS SEISDEDOS R, Crespo-Facorro B, Ayesa-Arriola R. European Journal of Psychotraumatology. 2020 Apr 23;11(1):1748342. doi: 10.1080/20008198.2020.1748342. PMID: 32373286

Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study. James S, Castle C, Dingels Z, et al. Injury Prevention. 2020 Oct;26(Supp 1):i125-i153. doi: 10.1136/injuryprev-2019-043531. PMID: 32839249

Five insights from the Global Burden of Disease Study 2019. Global Burden Dis 2019. Lancet. 2020 Oct 17;396(10258):1135-1159. doi: 10.1016/S0140-6736(20)31404-5. PMID: 33069324

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. GBD 2019 Demographics. Lancet. 2020 Oct 17;396(10258):1160-1203. doi: 10.1016/S0140-6736(20)30977-6. PMID: 33069325

Global and regional burden of cancer in 2016 arising from occupational exposure to selected carcinogens: a systematic analysis for the Global Burden of Disease Study 2016. Driscoll T, Rushton L, Steenland K, GBD 2016 Occupational Carcinogens Collaborators. Occupational And Environmental Medicine. 2020 Mar;77(3):151-159. doi: 10.1136/oemed-2019-106012. PMID: 32054819

Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Occupational Chronic Respiratory Risk Factors Collaborators. Occupational And Environmental Medicine. 2020 Mar;77(3):142-150. doi: 10.1136/oemed-2019-106013. PMID: 32054818

Global and regional burden of disease and injury in 2016 arising from occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Occupational Risk Factors Collaborators. Occupational And Environmental Medicine. 2020 Mar;77(3):133-141. doi: 10.1136/oemed-2019-106008. PMID: 32054817

Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. GBD 2019 Diss Injuries. Lancet. 2020 Oct 17;396(10258):1204-1222. doi: 10.1016/S0140-6736(20)30925-9. PMID: 33069326

Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. GBD 2019 Risk Factors. Lancet. 2020 Oct 17;396(10258):1223-1249. doi: 10.1016/S0140-6736(20)30752-2. PMID: 33069327

Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017. James S, Castle C, Dingels Z, et al. Injury Prevention. 2020 Oct;26(Supp 1):i96-i114. doi: 10.1136/injuryprev-2019-043494. PMID: 32332142

Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis. Catala Lopez F, Aleixandre-Benavent R, Caulley L, Hutton B, Tabarés Seisdedos R, Moher D, Alonso-Arroyo A. Trials. 2020 Jan 7;21(1):34. doi: 10.1186/s13063-019-3944-9. PMID: 31910857

Grip Strength, Neurocognition, and Social Functioning in People WithType-2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia. Alino-Dies M, Sanchez-Orti J, Correa-Ghisays P, Balanza-Martinez V, Vila-Frances J, Selva-Vera G, Correa-Estrada P, Fores-Martos J, San-Martin Valenzuela C, Monfort-Panego M, Ayesa-Arriola R, Ruiz-Veguilla M, Crespo-Facorro B, Tabares-Seisdedos R. Frontiers in Psychology. 2020 Nov 25;11:525231. doi: 10.3389/fpsyg.2020.525231. PMID: 33324271

Health sector spending and spending on HIV/AIDS, tuberculosis, and malaria, and development assistance for health: progress towards Sustainable Development Goal 3. Global Burden of Disease Health Financing Collaborator Network, Tabarés Seisdedos R, Global Burden of Disease Health Financing Collaborator Network. Lancet. 2020 5-11 Sep;396(10252):693-724. doi: 10.1016/S0140-6736(20)30608-5. PMID: 32334655

Interpreting molecular similarity between patients as a determinant of disease comorbidity relationships. Sanchez-Valle J, Tejero H, Fernandez J, Juan D, Urda-Garcia B, Capella-Gutierrez S, Al-Shahrour F, Tabarés Seisdedos R, Baudot A, Pancaldi V, Valencia A. Nature Communications. 2020 Jun 5;11(1):2854. doi: 10.1038/s41467-020-16540-x. PMID: 32504002

Mapping child growth failure across low- and middle-income countries. Local Burden of Disease Child Growth Failure Collaborators. Nature. 2020 Jan;577(7789):231-234. doi: 10.1038/s41586-019-1878-8. PMID: 31915393

Mapping disparities in education across low- and middle-income countries. Local Burden of Disease Educational Attainment Collaborators. Nature. 2020 Jan;577(7789):235-238. doi: 10.1038/s41586-019-1872-1. PMID: 31875853

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17. Local Burden of Disease WaSH Collaborators. The Lancet. Global health. 2020 Sep;8(9):e1162-e1185. doi: 10.1016/S2214-109X(20)30278-3. PMID: 32827479

Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17. Local Burden of Disease Diarrhoea Collaborators. The Lancet. Global health. 2020 Aug;8(8):e1038-e1060. doi: 10.1016/S2214-109X(20)30230-8. PMID: 32710861

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017. LBD Double Burden of Malnutrition Collaborators. Nature Medicine. 2020 May;26(5):750-759. doi: 10.1038/s41591-020-0807-6. PMID: 32313249

Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Gbd Universal Hlth Coverage. Lancet. 2020 Oct 17;396(10258):1250-1284. doi: 10.1016/S0140-6736(20)30750-9. PMID: 32861314

Morbidity and mortality from road injuries: results from the Global Burden of Disease Study 2017. James S, Lucchesi L, Bisignano C, Castle C, Dingels Z, Fox J, Hamilton E, Liu Z, McCracken D, Nixon M, Sylte D, Roberts N, Adebayo O, Aghamolaei T, Alghnam S, Aljunid S, Almasi-Hashiani A, Badawi A, Behzadifar M, Behzadifar M, Bekru E, Bennett D, Chapman J, Deribe K, Duko Adema B, Fatahi Y, Gelaw B, Getahun E, Hendrie D, Henok A, Hidru H, Hosseinzadeh M, Hu G, Jahani M, Jakovljevic M, Jalilian F, Joseph N, Karami M, Kelbore A, Khan M, Kim Y, Koul P, La Vecchia C, Linn S, Majdzadeh R, Mehndiratta M, Memiah P, Mengesha M, Merie H, R Miller T, Mirzaei-Alavijeh M, Mohammad Darwesh A, Mohammad Gholi Mezerji N, Mohammadibakhsh R, Moodley Y, Moradi-Lakeh M, Musa K, Nascimento B, Nikbakhsh R, Nyasulu P, Omar Bali A, Onwujekwe O, Pati S, Pourmirza Kalhori R, Salehi F, Shahabi S, Shallo S, Shamsizadeh M, Sharafi Z, Shukla S, Sobhiyeh M, Soriano J, Sykes B, Tabarés Seisdedos R, Tadesse D, Tefera Y, Tehrani-Banihashemi A, Tlou B, Topor-Madry R, Wiangkham T, Yaseri M, Yaya S, Yenesew M, Younis M, Ziapour A, Zodpey S, Pigott D, Reiner R, Hay S, Lopez A, Mokdad A. Injury Prevention. 2020 Oct;26(Supp 1):i46-i56. doi: 10.1136/injuryprev-2019-043302. PMID: 31915274

Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy. San Martín Valenzuela C, Borras-Barrachina A, Gallego Roig J, Urios Lluch M, Mestre Salvador V, Correa Ghisays P, Ballester Ferre M, Escudero Garcia A, Tosca Cuquerella J, Monton Rodríguez C, Rios M, Kosenko E, Felipo V, Tabarés Seisdedos R, Selva Vera G, Montoliu Félix M. Journal of Clinical Medicine. 2020 Jul 8;9(7):2154. doi: 10.3390/jcm9072154. PMID: 32650464

Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and Siblings. Tatay-Manteiga A, Balanza Martinez V, Bristot G, Tabarés Seisdedos R, Kapczinski F, Cauli O. Endocrine, metabolic & immune disorders drug targets. 2020;20(1):77-86. doi: 10.2174/1871530319666190307165355. PMID: 30848220

Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis. Catala Lopez F, Caulley L, Ridao M, Hutton B, Husereau D, Drummond M, Alonso-Arroyo A, Pardo-Fernandez M, Bernal-Delgado E, Meneu R, Tabarés Seisdedos R, Repullo J, Moher D. BMJ Open. 2020 Feb 13;10(2):e034463. doi: 10.1136/bmjopen-2019-034463. PMID: 32060160

Cataracts and statins. A disproportionality analysis using data from VigiBase. Macías Saint-Gerons D, Bosco Cortez F, Jiménez López G, Castro JL, Tabarés-Seisdedos R. Regulatory toxicology and pharmacology. 2019.Dec;109:104509. doi: 10.1016/j.yrtph.2019.104509. PMID: 31669197

CIBERSAM: Ten years of collaborative translational research in mental disorders. Salagre E, Arango C, Artigas F, Ayuso-Mateos JL, Bernardo M, Castro-Fornieles J, Bobes J, Desco M, Fañanás L, González-Pinto A, Haro JM, Leza JC, Mckenna PJ, Meana JJ, Menchón JM, Micó JA, Palomo T, Pazos Á, Pérez V, Saiz-Ruiz J, Sanjuán J, Tabarés-Seisdedos R, Crespo-Facorro B, Casas M, Vilella E, Palao D, Olivares JM, Rodriguez-Jimenez R, Vieta E. Revista de Psiquiatria y Salud Mental. 2019 Jan-Mar;12(1):1-8. doi: 10.1016/j.rpsm.2018.10.001. PMID: 30416047

Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Dementia Collaborators. Lancet Neurology. 2019 Jan;18(1):88-106. doi: 10.1016/S1474-4422(18)30403-4. PMID: 30497964

Global, regional, and national burden of brain and other CNS cancer, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Brain and Other CNS Cancer Collaborators. Lancet Neurology. 2019 Apr;18(4):376-393. doi: 10.1016/S1474-4422(18)30468-X. PMID: 30797715

Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Epilepsy Collaborators. Lancet Neurology. 2019 Apr;18(4):357-375. doi: 10.1016/S1474-4422(18)30454-X. PMID: 30773428

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Neurology Collaborators. Lancet Neurology. 2019 May;18(5):459-480. doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893

Global, regional, and national burden of suicide mortality 1990 to 2016: systematic analysis for the Global Burden of Disease Study 2016. Naghavi M; Global Burden of Disease Self-Harm Collaborators. BMJ-British Medical Journal. 2019 Feb 6;364:l94. doi: 10.1136/bmj.l94. PMID: 31339847

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. Lancet Neurology. 2019 Jan;18(1):56-87. doi: 10.1016/S1474-4422(18)30415-0. PMID: 30497965

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. Global Burden of Disease Cancer Collaboration. JAMA Oncology. 2019 Dec 1;5(12):1749-1768. doi: 10.1001/jamaoncol.2019.2996. PMID: 31560378

Mapping 123 million neonatal, infant and child deaths between 2000 and 2017. Burstein R, Henry NJ, Collison ML, et al. Nature. 2019 Oct;574(7778):353-358. doi: 10.1038/s41586-019-1545-0. PMID: 31619795

Neurocognitive endophenotypes in schizophrenia and bipolar disorder: A systematic review of longitudinal family studies. Luperdi SC, Tabarés-Seisdedos R, Livianos L, Vieta E, Cuesta MJ, Balanzá-Martínez V. Schizophrenia Research. 2019 Aug;210:21-29. doi: 10.1016/j.schres.2019.06.014. PMID: 31272906

Past, present, and future of global health financing: a review of development assistance, government, out-of-pocket, and other private spending on health for 195 countries, 1995-2050. Global Burden of Disease Health Financing Collaborator Network. Lancet. 2019 Jun 1;393(10187):2233-2260. doi: 10.1016/S0140-6736(19)30841-4. PMID: 31030984

Prevalence and comorbidity of attention deficit hyperactivity disorder in Spain: study protocol for extending a systematic review with updated meta-analysis of observational studies. Catala Lopez F, Ridao M, Núñez-Beltrán A, Gènova-Maleras R, Alonso-Arroyo A, Aleixandre-Benavent R, Catalá M, Tabarés Seisdedos R. Systematic Reviews. 2019 Feb 11;8(1):49. doi: 10.1186/s13643-019-0967-y. PMID: 30744675

Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies. Catala Lopez F, Ridao M, Hurtado I, Nunez-Beltran A, Genova-Maleras R, Alonso-Arroyo A, Tobias A, Aleixandre-Benavent R, Catala M, Tabarés Seisdedos R. Systematic Reviews. 2019 Jun 14;8(1):141. doi: 10.1186/s13643-019-1061-1. PMID: 31200773

Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library. Catalá-López F, Alonso-Arroyo A, Page MJ, Hutton B, Ridao M, Tabarés-Seisdedos R, Aleixandre-Benavent R, Moher D. BMJ Open. 2019 Mar 4;9(3):e022769. doi: 10.1136/bmjopen-2018-022769. PMID: 30837245

Subjective neurocognition and quality of life in patients with bipolar disorder and siblings. Tatay-Manteiga A, Cauli O, Tabarés-Seisdedos R, Michalak EE, Kapczinski F, Balanzá-Martínez V. Journal of Affective Disorders. 2019 Feb 15;245:283-288. doi: 10.1016/j.jad.2018.11.012. PMID: 30419528

The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017. GBD 2017 Childhood Cancer Collaborators.. Lancet Oncology. 2019 Sep;20(9):1211-1225. doi: 10.1016/S1470-2045(19)30339-0. PMID: 31371206

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cáncer. Forés-Martos J, Catalá-López F, Sánchez-Valle J, Ibáñez K, Tejero H, Palma-Gudiel H, Climent J, Pancaldi V, Fañanás L, Arango C, Parellada M, Baudot A, Vogt D, Rubenstein JL, Valencia A, Tabarés-Seisdedos R. Molecular Autism. 2019 Apr 8;10:17. doi: 10.1186/s13229-019-0262-8. PMID: 31007884

Visual memory dysfunction as a neurocognitive endophenotype in bipolar disorder patients and their unaffected relatives. Evidence from a 5-year follow-up Valencia study. Correa-Ghisays P, Sánchez-Ortí JV, Ayesa-Arriola R, Setién-Suero E, Balanzá-Martínez V, Selva-Vera G, Ruiz-Ruiz JC, Vila-Francés J, Martinez-Aran A, Vivas-Lalinde J, Conforte-Molina C, San-Martín C, Martínez-Pérez C, Fuentes-Durá I, Crespo-Facorro B, Tabarés-Seisdedos R. Journal of Affective Disorders. 2019 Oct 1;257:31-37. doi: 10.1016/j.jad.2019.06.059. PMID: 31299402

Proyectos
Referencia: PI17/00719
Título: Identificación de biomarcadores epigenéticos periféricos asociados con el déficit neurocognitivo en personas con trastorno bipolar, depresión, esquizofrenia y diabetes tipo 2
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: Rafael Tabarés Seisdedos
Duración: 2018 – 2020
Presupuesto: 105.270 €

Referencia: CB07/09/0021
Título: CIBER de Enfermedades Mentales (CIBERSAM)
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: Rafael Tabarés Seisdedos
Duración: 2015 –
Presupuesto:

+ Información
Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library. Catalá-López F, Alonso-Arroyo A, Page MJ, Hutton B, Ridao M, Tabarés-Seisdedos R, Aleixandre-Benavent R, Moher D. BMJ Open. 2019 Mar 4;9(3):e022769. doi: 10.1136/bmjopen-2018-022769. PMID: 30837245

Título: Funcionamiento neurocognitivo y psicosocial de pacientes con trastorno bipolar en una Unidad de Salud Mental
Doctorando: Vidal Rubio, Sonia del Lluch
Director: Balanzá Martínez, Vicent; Romeu Climent, José Enrique
Fecha: 19/06/2019
Universidad: Universitat de València

Título: Terapia celular en enfermedades desmielinizantes
Doctorando: Jaramillo Merchán, Jesús Alfonso
Director: Martínez Pérez, Salvador; Jones Barbera, Jonathan Richard
Fecha: 12/02/2021
Universidad: Universitat de València