Dr. Miguel Ángel García Pérez
Principal Investigator
Research Group on Genetics of Osteoporosis
Presentation
Dr. Miguel Angel García Pérez is Professor of Genetics at the University of Valencia (UV). He received his doctorate in Biological Sciences from the Cytological Research Institute of the Valencian Foundation for Biomedical Studies. After a brief postdoctoral stay at the Institut de Genetique et de Biologie Moleculaire et Cellulaire from Strasbourg, trained as a Resident Internal Biologist in immunology at Hospital 12 de Octubre in Madrid. In 2002 he obtained a position as a Researcher of the National Health System at the Clinical Hospital of Valencia and later at its Foundation, achieving stabilization in 2008. Since 2011 he has been a researcher attached to INCLIVA.
His main area of interest and research is the genetics of postmenopausal osteoporosis and the functional characterization of the detected genetic variants. He is also very interested in the identification of genetic and epigenetic biomarkers of prevalent bone phenotypes such as osteoporosis, fragility fracture, and severe osteoarthritis. He has worked for a long time with a mouse model of accelerated bone loss such as ovariectomized mice. In this model, he has studied the interrelationship between the immune and bone systems and has served as a source of candidate genes for their translational study in women. More recently, a new line of research began consisting of the genetic study of patients with chromosome 15 duplication inversion syndrome (Idic-15).
He is the author of about 100 articles in different magazines, most of them international, and 14 book chapters. He has participated in about 20 research projects, of which 8 are R+D+I projects (4 as principal investigator) and 2 international projects. He has participated as an expert evaluator in some 15 international journals and as an evaluator of research projects and contracts for the Agencies ANEP, AEI, ACSUCYL, United States -Israel Binational Science Foundation, National Science Center (Poland), Ministry of Health of the Junta de Andalucía, Ministry of Science and Innovation, and Ministry of Economy and Competitiveness.
Publications
Mediterranean diet for cancer prevention and survivorship. Monllor-Tormos A, Garcia-Vigara A, Morgan O, Garcia-Perez M, Mendoza N, Tarin J, Cano A. Maturitas. 2023 Dec:178:107841. doi: 10.1016/j.maturitas.2023.107841. PMID: 37660598
The covid-19 pandemic and the usability of telehealth in a midlife women’s health integrated care program. Garcia-Vigara A, Martin-Gonzalez V, Carbonell J, Bauset-Castello C, Martinez-Aspas A, Monllor-Tormos A, Garcia-Perez M, Tarin J, Cano A. Maturitas. 2023 Feb;168:7-12. doi: 10.1016/j.maturitas.2022.10.011. PMID: 36370490
Metabolomic analysis of severe osteoarthritis in a Spanish population of women compared to healthy and osteoporotic subjects. Pertusa C, Mifsut D, Morales J, Tarin J, Cano A, Monleon D, Garcia-Perez M. Metabolites. 2022 Jul 24;12(8):677. doi: 10.3390/metabo12080677. PMID: 35893245
Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study. Pertusa C, Tarin JJ, Cano A, Garcia-Perez MA, Mifsut D. Scientific Reports. 2021 Sep 29;11(1):19372. doi: 10.1038/s41598-021-98789-w. PMID: 34588560
Variants translating reduced expression of the beta estrogen receptor gene were associated with increased carotid intima media thickness: A cross-sectional study in late postmenopausal women. Cano-Marquina AJ, Garcia-Perez MA, Tarin JJ, Maceira AM, Cosin-Sales J, Cano A. Medicine. 2021 Jun 11;100(23):e26216. doi: 10.1097/MD.0000000000026216. PMID: 34115005
A predictive model for women’s assisted fecundity before starting the first IVF/ICSI treatment cycle. Tarin Folgado J, Pascual E, García Pérez M, Gómez Gallego R, Hidalgo Mora J, Cano Sanchez A. Journal of Assisted Reproduction and Genetics. 2020 Jan;37(1):171-180. doi: 10.1007/s10815-019-01642-3. PMID: 31797243
Association of a single nucleotide polymorphism of RANK gene with blood pressure in Spanish women. Pertusa Viñuales C, Tarin Folgado J, Cano Sanchez A, García Pérez M. Medicine. 2020 Oct 2;99(40):e22436. doi: 10.1097/MD.0000000000022436. PMID: 33019425
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis. Panach Gonzalez L, Pertusa Viñuales C, Martinez Rojas B, Acebrón Fabregat Á, Mifsut Miedes D, Tarin Folgado J, Cano Sanchez A, García Pérez M. Scientific Reports. 2020 Oct 1;10(1):16298. doi: 10.1038/s41598-020-72870-2. PMID: 33004909
Cumulative probabilities of live birth across multiple complete IVF/ICSI cycles: a call for attention. Tarin Folgado J, Pascual E, Perez-Hoyos S, Gómez Gallego R, García Pérez M, Cano Sanchez A. Journal of Assisted Reproduction and Genetics. 2020 Jan;37(1):141-148. doi: 10.1007/s10815-019-01608-5. PMID: 31808046
Projects
Title: Evidence-Based Guidance to Scale-up Integrated Care in Europe (VIGOUR)
Funding body: Agencia Ejecutiva de Consumidores, Salud, Agricultura y Alimentación
Principal Investigator: Antonio Cano Sánchez, Juan J. Tarín, Miguel Ángel García Pérez
Duration: 2019 – 2021
Total budget: 3.046.024,67
Title: Osteoporosis y fractura ósea: identificación de genes asociados y evaluación del papel del metabolismo de la arginina
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Miguel Ángel García Pérez
Duration: 2018 – 2021
Total budget: 99.220 €
+ Info
Doctoral candidate: Zolfaroli, Irene
Director(s): García Pérez, Miguel Ángel; Cano Sánchez, Antonio
Date of the defense: 27/02/2019
University: Universitat de València