Dr. Manuel Mata Roig

Principal Investigator
Research Group on Histopathology and Tissue Engineering


Dr. Manuel Mata Roig has a degree in Biology (1997) from the University of Alicante. In 2000 he obtained an FPI scholarship that allowed him to carry out his doctoral thesis focused on the development of a functional in vitro model of respiratory mucosa for drug screening (Universitat de València, 2003) in the research group directed by Professor Morcillo. He has experience in in vivo and in vitro experimental models (human tissues and primary epithelial, endothelial, fibroblastic and smooth muscle cells) as well as in the development of several drugs, highlighting the PDE4 inhibitor Roflumilast (finally approved by the FDA and the Agency Spanish Medicine for the treatment of COPD). His postdoctoral experience includes collaborations with prestigious international research groups such as the one led by Nobel Prize winner Eric J Kandel.
He is the author of more than ninety articles published in JCR (2176 total citations, H-index of 26) and has led competitive funded research projects continuously since 2011.
Both researchers currently collaborate with renowned researchers in the field of tissue engineering such as professors José Luis Gómez Ribelles or Manuel Monleón Prada from CBIT (UPV), professor Julio Suay from UJI or professor Antonio Campos Muñoz from the University of Granada.

Dr. Manuel Mata Roig


Cadaveric adipose-derived stem cells for regenerative medicine and research. Milián L, Molina P, Oliver-Ferrándiz M, Fernández-Sellers C, Monzó A, Sánchez-Sánchez R, Braza-Boils A, Mata M, Zorio E. International Journal of Molecular Sciences. 2023 Oct 28;24(21):15696. doi: 10.3390/ijms242115696. PMID: 37958680

Low-Dose gamma radiation sterilization for decellularized tracheal grafts. Martinez-Hernandez N, Milian-Medina L, Mas-Estelles J, Monroy-Anton J, Lopez-Villalobos J, Hervas-Marin D, Roig-Bataller A, Mata-Roig M. Jove-Journal of Visualized Experiments. 2023 Apr 14;(194). doi: 10.3791/64432. PMID: 37125805

Morphological characterization of human lung cancer organoids cultured in type I collagen hydrogels: a histological approach. Monleon-Guinot I, Milian L, Martinez-Vallejo P, Sancho-Tello M, Llop-Miguel M, Galbis J, Cremades A, Carda C, Mata M. International Journal of Molecular Sciences. 2023 Jun 14;24(12):10131. doi: 10.3390/ijms241210131. PMID: 37373279

BMP-2 enhances osteogenic differentiation of human adipose-derived and dental pulp stem cells in 2D and 3D in vitro models. Martin-Iglesias S, Milian L, Sancho-Tello M, Salvador-Clavell R, de Llano J, Carda C, Mata M. Stem Cells International. 2022 Mar 4;2022:4910399. doi: 10.1155/2022/4910399. PMID: 35283997

Correlation between biological responses in vitro and in vivo to Ca-doped sol-gel coatings assessed using proteomic análisis. Garcia-Arnaez I, Romero-Gavilan F, Cerqueira A, Elortza F, Azkargorta M, Munoz F, Mata M, de Llano J, Suay J, Gurruchaga M, Goni I. Colloids and Surfaces B-Biointerfaces. 2022 Oct 21;220:112962. doi: 10.1016/j.colsurfb.2022.112962. PMID: 36306698

Human dental pulp stem cells differentiate into cementoid-like-secreting cells on decellularized teeth scaffolds. Mata M, Peydro S, de Llano J, Sancho-Tello M, Carda C. International Journal of Molecular Sciences. 2022 Dec 9;23(24):15588. doi: 10.3390/ijms232415588. PMID: 36555228

A standardised approach to the biomechanical evaluation of tracheal grafts. Martinez-Hernandez N, Mas-Estelles J, Milian-Medina L, Martinez-Ramos C, Ceron-Navarro J, Galbis-Caravajal J, Roig-Bataller A, Mata-Roig M. Biomolecules. 2021 Oct 5;11(10):1461. doi: 10.3390/biom11101461. PMID: 34680094

Alginate-agarose hydrogels improve the in vitro differentiation of human dental pulp stem cells in chondrocytes. A histological study. Oliver-Ferrandiz M, Milian L, Sancho-Tello M, de Llano J, Roca F, Martinez-Ramos C, Carda C, Mata M. Biomedicines. 2021 Jul 17;9(7):834. doi: 10.3390/biomedicines9070834. PMID: 34356898

Chondrogenic potential of human dental pulp stem cells cultured as microtissues. Salvador-Clavell R, Martin de Llano J, Milian L, Oliver M, Mata M, Carda C, Sancho-Tello M. Stem Cells International. 2021 Sep 7;2021:7843798. doi: 10.1155/2021/7843798. PMID: 34539791

Decellularized tracheal prelamination implant: A proposed bilateral double organ technique. Martinez-Hernandez N, Diaz-Cuevas A, Milian-Medina L, Sancho-Tello M, Rosello-Ferrando J, Morcillo-Aixela A, Campo-Canaveral J, Roig-Bataller A, Mata-Roig M. Artificial Organs. 2021 Dec;45(12):1491-1500. doi: 10.1111/aor.14043. PMID: 34310703

High-speed video microscopy for primary ciliary dyskinesia diagnosis: a study of ciliary motility variations with time and temperatura. Reula A, Pitarch-Fabregat J, Milara J, Cortijo J, Mata-Roig M, Milian L, Armengot M. Diagnostics. 2021 Jul 20;11(7):1301. doi: 10.3390/diagnostics11071301. PMID: 34359383

Optimization of a decellularization protocol of porcine tracheas. Long-term effects of cryopreservation. A histological study. Milian L, Sancho-Tello M, Roig-Soriano J, Foschini G, Martinez-Hernandez NJ, Mas-Estelles J, Ruiz-Sauri A, Zurriaga J, Carda C, Mata M. The International Journal of Artificial Organs. 2021 Dec;44(12):998-1012. doi: 10.1177/03913988211008912. PMID: 33863248

Reference: PID2019-106099RB-C42
Title: Microgeles biomiméticos para el estudio del microentorno del tumor (TME) y la transición epitelio mesénquima (EMT) en cáncer de pulmón
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Manuel Mata Roig, José Javier Martín de Llano
Duration: 2020 – 2023
Total budget: 151.250 €
Reference: PI16/01315
Title: Sustitutos traqueales epitelizados generados por ingeniería
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Miguel Armengot, Manuel Mata
Duration: 2017 – 2020
Total budget: 68.365 €
+ Info
Title: Sustitutos traqueales generados por ingeniería tisular
Doctoral candidate: Foschini Martinez, Giovanna
Director(s): Galán Gil, Genaro; Mata Roig, Manuel; Carda Batalla, Carmen
Date of the defense: 06/05/2022
University: Universitat de València

Title: Regeneración de cartílago mediante el uso de células madre de pulpa dental humanas (HDPSCS)
Doctoral candidate: Oliver Ferrándiz, María
Director(s): Mata Roig, Manuel; Martín De Llano, José Javier
Date of the defense: 04/03/2021
University: Universitat de València