Dr. David Navarro Ortega
Principal Investigator
Research Group on Molecular Microbiology and Microbial Pathogenesis
Presentation

Publications
Antibiotic susceptibility and genotypic characterization of Neisseria gonorrhoeae isolates in the Comunidad Valenciana (Spain): GONOvig project. Fabregat Bolufer AB, Bueno Ferrando F, Navarro Ortega D, Colomina Rodriguez J. Enfermedades Infecciosas y Microbiologia Clínica. 2023 Jan 14;S2529-993X(23)00001-1. doi: 10.1016/j.eimce.2022.08.009. PMID: 36646588
Cumulative incidence of SARS-CoV-2 infection in the general population of the Valencian Community (Spain) after the surge of the Omicron BA.1 variant. Camacho J, Gimenez E, Albert E, Zulaica J, Alvarez-Rodriguez B, Torres I, Rusu L, Burgos J, Peiro S, Vanaclocha H, Limon R, Alcaraz M, Sanchez-Paya J, Diez-Domingo J, Comas I, Gonzales-Candelas F, Geller R, Navarro D. Journal of Medical Virology. 2023 Jan;95(1):e28284. doi: 10.1002/jmv.28284. PMID: 36333837
Cytomegalovirus DNAemia in hematological patients undergoing CD19-directed CAR-T cell therapy: should it be systematically monitored?. Solano de la Asuncion C, Hernani R, Albert E, Gomez M, Gimenez E, Benzaquen A, Gonzalez-Barbera E, Hernandez-Boluda J, Perez A, Pinana J, Chorao P, Guerreiro M, Montoro J, Sanz J, Solano C, Navarro D. Clinical Microbiology and Infection. 2023 May 12;S1198-743X(23)00234-3. doi: 10.1016/j.cmi.2023.05.010. PMID: 37182642
Dynamics of Human Anelloviruses in plasma and clinical outcomes following kidney transplantation. Forque L, Fernandez-Ruiz M, Albert E, Gimenez E, Monzo C, Chaves J, Redondo N, Rodriguez-Goncer I, Ruiz-Merlo T, Parra P, Andres A, Aguado JM, Navarro D. Transplantation. 2023 Feb 1;107(2):511-520. doi: 10.1097/TP.0000000000004292. PMID: 36042550
Applicability of probabilistic graphical models for early detection of SARS-CoV-2 reactive antibodies after SARS-CoV-2 vaccination in hematological patients. Pinana J, Rodriguez-Belenguer P, Caballero D, Martino R, Lopez-Corral L, Terol M, Vazquez L, Calabuig M, Sanz-Linares G, Marin-Jimenez F, Alonso C, Montoro J, Ferrer E, Facal A, Pascual M, Rodriguez-Fernandez A, Olave M, Cascales-Hernandez A, Gago B, Hernandez-Rivas J, Villalon L, Corona M, Roldan-Perez A, Ribes-Amoros J, Gonzalez-Santillana C, Garcia-Sanz R, Navarro D, Serrano-Lopez A, Cedillo A, Soria-Olivas E, Sureda A, Solano C. Annals of Hematology. 2022 Sep;101(9):2053-2067. doi: 10.1007/s00277-022-04906-8. PMID: 35780254
BD MAX enteric bacterial, bacterial plus, and virus panels for diagnosis of acute infectious gastroenteritis: a cost-benefit analysis. Ferrer J, Gimenez E, Carretero D, Buesa J, Morillas F, Granell R, Fuenmayor A, Navarro D, Albert E. Microbiology Spectrum. 2022 Oct 26;10(5):e0088022. doi: 10.1128/spectrum.00880-22. PMID: 36069590
Booster effect after SARS-CoV-2 vaccination in immunocompromised hematology patients with prior COVID-19. Piñana JL, Garcia-Sanz R, Martino R, Garcia-Roa M, Martin-Martin GA, Risco-Gálvez I, Tormo M, Martinez-Barranco P, Marcos-Corrales S, Calabuig M, Conesa V, Teruel A, Ruiz-Pérez S, Solano C, Navarro D, Cedillo Á, Sureda A. Blood Advances. 2022 Jan 8;6(3):848-853. doi: 10.1182/bloodadvances.2021006326. PMID: 34905620
CAPA in progress: a new real-life approach for the management of critically ill COVID-19 patients. Carbonell N, Alcaraz M, Serrano-Lazaro A, Rodriguez-Gimillo M, Ramos D, Ros F, Ferrer J, Blasco M, Navarro D, Clari M. Biomedicines. 2022 Jul 13;10(7):1683. doi: 10.3390/biomedicines10071683. PMID: 35884988
Amplification of human beta-glucoronidase gene for appraising the accuracy of negative SARS-CoV-2 RT-PCR results in upper respiratory tract specimens. Albert Vicent E, Ferrer Lores B, Torres Fink I, Serrano Alcalá A, Alcaráz Soriana M, Buesa Gomez J, Solano Vercet C, Colomina Rodríguez F, Bueno Ferrando F, Huntley Pascual D, Olea Miguel B, Valdivia Piqueres A, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):48-50. doi: 10.1002/jmv.26112. PMID: 32484950
Assessing the potential association between SARS-CoV-2 RNA load in the respiratory tract and COVID-19 mortality. Albert E, Bracho M, Serrano A, Ferrer B, Gonzalez-Candelas F, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):1862-1864. doi: 10.1002/jmv.26644. PMID: 33135804
Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure. Mollar A, Marrachelli V, Nunez E, Monleon D, Bodi V, Sanchis J, Navarro D, Nunez J. Scientific reports. 2021 Mar 17;11(1):6110. doi: 10.1038/s41598-021-85527-5. PMID: 33731747
Caveats in interpreting SARS-CoV-2 IgM positive/IgG negative antibody profile in asymptomatic health care workers.. Valdivia Piqueres A, Torres Fink I, Huntley Pascual D, Alcaráz Soriana M, Albert Vicent E, Solano De La Asunción C, González Padrón C, Ferrer Dot J, Navarro Ortega D. Journal of Medical Virology. 2021 Feb;93(2):634-636. doi: 10.1002/jmv.26400. PMID: 32761912
An investigation of the utility of plasma Cytomegalovirus (CMV) microRNA detection to predict CMV DNAemia in allogeneic hematopoietic stem cell transplant recipients. Talaya Peñalver A, Gimenez Quiles E, Pascual M, Gago B, Piñana Sanchez J, Hernandez Boluda J, Vazquez L, Garcia M, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Medical Microbiology And Immunology. 2020 Feb;209(1):15-21. doi: 10.1007/s00430-019-00632-7. PMID: 31478067
Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell transplantation. Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Hernandez Boluda J, Gimenez Quiles E, Gomez M, Balaguer-Rosello A, Gonzalez-Barbera E, Guerreiro M, Aguilar C, Navarro Ortega D, Solano Vercet C, Sanz J, Luis Pinana J. Transplant Infectious Disease. 2020 Aug;22(4):e13301. doi: 10.1111/tid.13301. PMID: 32363665
Assessment of prevalence and load of torquetenovirus viraemia in a large cohort of healthy blood donors. Focosi D, Spezia P, Macera L, Salvadori S, Navarro Ortega D, Lanza M, Antonelli G, Pistello M, Maggi F. Clinical Microbiology and Infection. 2020 Oct;26(10):1406-1410. doi: 10.1016/j.cmi.2020.01.011. PMID: 31972321
Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens. Luis Pinana J, Albert Vicent E, Dolores Gomez M, Perez Martinez A, Hernandez Boluda J, Montoro J, Salavert M, Maria Gonzalez E, Tormo Diaz M, Gimenez Quiles E, Villalba M, Balaguer-Rosello A, Hernani Morales R, Bueno Ferrando F, Borras Salvador R, Sanz J, Solano Vercet C, Navarro Ortega D. The Journal of infection. 2020 May;80(5):578-606. doi: 10.1016/j.jinf.2020.01.001. PMID: 31926954
Projects
Title: Inmunidad adaptativa de linfocitos B y T frente a SARS-CoV-2 tras la vacunación de pacientes en riesgo de sufrir COVID-19 severa
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: David Navarro Ortega, Estela Giménez
Duration: 2022 – 2024
Total budget: 169.400 €
Title: Personalisation of immunosuppression by monitoring viral load post kidney transplantation – a randomised controlled phase II trial
Funding body: European Commission
Principal Investigator: David Navarro Ortega
Duration: 2021 – 2026
Total budget: 85.625 €
Title: Anellovirus y Pegivirus un posible marcador del estado neto de inmunosupresión: evaluación en el trasplante alogénico de progenitores hematopoyéticos
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Estela Giménez Quiles
Duration: 2020 – 2021
Total budget: 16.000 €
Title: Virología e inmunología de la infección por el citomegalovirus (CMV) en el paciente con neoplasia hematológicas en la era de las nuevas bioterapias
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: David Navarro Ortega
Duration: 2019 – 2022
Total budget: 111.320 €
Title: Inmunobiología de la infección por el citomegalovirus en el trasplante alogénico de precursores hematopoyéticos haploidéntico asociado al uso de ciclofosfamida postrasplante
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: David Navarro Ortega
Duration: 2016 – 2019
Total budget: 98.615 €
+ Info
Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7). Ljungman P, de la Camara R, Robin C, Crocchiolo R, Einsele H, Hill JA6, Hubacek P7, Navarro D8, Cordonnier C3, Ward KN9; 2017 European Conference on Infections in Leukaemia group. LANCET INFECTIOUS DISEASES. 2019 Aug; 19(8): e260-e272. doi: 10.1016/S1473-3099(19)30107-0. PMID: 31153807
Doctoral candidate: Torres Fink, Ignacio
Director(s): Navarro Ortega, David
Date of the defense: 14/07/2022
University: Universitat de València
Title: Valor predictivo de la carga viral de citomegalovirus y torquetenovirus en heces y plasma del desarrollo de la enfermedad injerto contra huésped intestinal en pacientes sometidos a trasplante alogénico de precursores hematopoyéticos
Doctoral candidate: Bueno Ferrando, Felipe
Director(s): Navarro Ortega, David
Date of the defense: 15/06/2022
University: Universitat de València
Title: Factores predictivos de desarrollo y evolución de infección activa por citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
Doctoral candidate: Vinuesa Velasco, Víctor
Director(s): Navarro Ortega, David
Date of the defense: 08/09/2021
University: Universitat de València
Title: Parámetros biológicos predictivos de la infección activa precoz por Citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
Doctoral candidate: Talaya Peñalver, Alberto
Director(s): Navarro Ortega, David
Date of the defense: 26/05/2021
University: Universitat de València
Title: Torque teno virus como marcador subrogado de inmunocompetencia en el trasplante
Doctoral candidate: Albert Vicent, Eliseo
Director(s): Navarro Ortega, David
Date of the defense: 13/02/2020
University: Universitat de València
Title: Concentración mínima inhibitoria de vancomicina para staphylococcus aureus y riesgo de bacteriemia complicada
Doctoral candidate: Falcón Abad, Rocío
Director(s): Navarro Ortega, David
Date of the defense: 02/10/2019
University: Universitat de València