Dr. Aymara Mas Perucho

Emerging Investigator
Research Group on Reproductive Medicine


Dr. Aymara Mas is a Senior Principal Investigator at the Carlos Simón Foundation and a Miguel Servet Researcher (ISCIII) at the INCLIVA Health Research Institute in Valencia.

Her research focuses on understanding the factors that contribute to the physiopathology of gynecological tumors that develop primarily in the myometrium and ovary.
Dr. Mas completed a 2-year international postdoctoral fellowship at Augusta University (Georgia, USA), which she completed at the La Fe Health Research Institute in Valencia with a Sara Borrell Grant (ISCIII), studying primarily uterine disorders.

Over the past 10 years, she has made significant contributions, such as proof of functional concept regarding the existence of somatic stem cells (CME) in the human myometrium and uterine leiomyomas (PMID: 24890270) based on side population methods (PMID: 22633281) and specific biomarkers (PMID: 25989979; PMID: 28395335). She has also collaborated with numerous groups to study the role of steroid hormone receptors (PMID: 27739139), signaling pathways (PMID: 30075150), and genetic (PMID: 25542836) and epigenetic (PMID: 25922306) alterations in the pathogenesis and growth of uterine leiomyomas, deepening new approaches to improve the efficacy of gene therapy against these benign tumors (PMID: 27020169). She has also revealed, through integrative genomic and transcriptomic profiling, the differential molecular signature of uterine leiomyomas versus leiomyosarcomas (PMID: 31121144; PMID: 35216305), leading to 2 patent applications.

Her commitment to research excellence is demonstrated by an established track record of 9 research projects (5 as principal investigator) and 32 basic and translational publications in peer-reviewed journals, with an average of 36.19 citations/publication. She has participated in national and international conferences and has been awarded internationally by the Society of Reproductive Investigation (SRI) and the American Society of Reproductive Medicine (ASRM). She also mentors medical students in their final year projects and doctoral students.

Currently, her team is using high-throughput sequencing technologies to identify molecular biomarkers associated with tumor growth and progression, in order to develop predictive models that will enable non-invasive therapeutic and preventive strategies.

Dra. Aymara Mas Perucho
Dr. Aymara Mas Perucho


Effect of aging on the human myometrium at single-cell resolution. Punzon-Jimenez P, Machado-Lopez A, Perez-Moraga R, Llera-Oyola J, Grases D, Galvez-Viedma M, Sibai M, Satorres-Perez E, Lopez-Agullo S, Badenes R, Ferrer-Gomez C, Porta-Pardo E, Roson B, Simon C, Mas A. Nature Communications. 2024 Jan 31;15(1):945. doi: 10.1038/s41467-024-45143-z. PMID: 38296945

Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids. Yang Q, Ali M, Trevino L, Mas A, Al-Hendy A. Cellular and Molecular Life Sciences. 2023 Aug 31;80(9):274. doi: 10.1007/s00018-023-04919-0. PMID: 37650943

The human periconceptional maternal-embryonic space in health and disease. Moreno I, Capalbo A, Mas A, Garrido-Gomez T, Roson B, Poli M, Dimitriadis E, Santamaria X, Vilella F, Simon C. Physiological Reviews. 2023 Jul 1;103(3):1965-2038. doi: 10.1152/physrev.00050.2021. PMID: 36796099

Uterine leiomyoma with RAD51B:NUDT3 fusion: a report of 2 cases. Dundr P, Machado-Lopez A, Mas A, Veckova Z, Mara M, Richtarova A, Matej R, Struzinska I, Bartu M, Nemejcova K, Dvorak J, Hojny J. Virchows Archiv. 2023 Jul 19. doi: 10.1007/s00428-023-03603-9. PMID: 37466765

Integrative genomic and transcriptomic profiling reveals a differential molecular signature in uterine leiomyoma versus leiomyosarcoma. Machado Lopez A, Alonso R, Lago V, Jimenez Almazan J, Garcia M, Monleon J, Lopez S, Barcelo F, Torroba A, Ortiz S, Domingo S, Simon C, Mas A. International Journal of Molecular Sciences. 2022 Feb 16;23(4):2190. doi: 10.3390/ijms23042190. PMID: 35216305

Molecular Management of High-Grade Serous Ovarian Carcinoma. Punzon-Jimenez P, Lago V, Domingo S, Simon C, Mas A. International Journal of Molecular Sciences. 2022 Nov 9;23(22):13777. doi: 10.3390/ijms232213777. PMID: 36430255

Reference: PI20/00942
Title: Desarrollo de un modelo predictivo para el diagnóstico diferencial temprano de leiomiomas y leiomiosarcomas uterinos
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Aymara Mas Perucho
Duration: 2021 – 2023
Total budget: 99.825 €