Research Group on Central Nervous System Tumors

Oncology Area

Clinical-pathological study of 40 patients affected by primary glioblastoma according to established protocol:

– Short-cell cultures and their viability analysis have been performed. Analysis by FISH of EGFR status and freezing of the different passes according to established methodology

– The study of the proteomic analysis of the 40 tumors (frozensamples) by Western Blott according to established methodology has been completed

Experimental study:

– Spheres (neurospheres) have been elaborated from different cell lines and cell cultures of glioblastoma, characterizing and analyzing their behavior

– Analysis of cultures subjected to silencing and overexpression by transfection of miRNAs by the lipofection method

– Analysis of cell cultures in hypoxia situation, analyzing their characteristics and behavior before silencing and overexpression by transfection of selected miRNAs in hypoxia situation and in the different amplification status of the EGFR

– The pilot study of viability and effectiveness of xenotransplantation in nude mice has been completed with the achievement of neoplasias under study

Dr. Miguel Cerdá Nicolás
Dr. Miguel Cerdá Nicolás

Leading, R4

Miguel Cerdá Nicolás    

Established, R3

Concepción López Ginés
Javier Megías Vericat
Pedro Roldán Badía
Teresa San Miguel Díez

Recognised/Emerging, R2

Pablo Cerdá Durán
Lisandra Muñoz Hidalgo

First Stage, R1
Collaborating Researchers

Lara Navarro Cerveró

Administrative assistant
Glucose 6-P dehydrogenase overexpression improves aging-induced endothelial dysfunction in aorta from mice: role of arginase II. Serna E, Mauricio MD, San Miguel T, Guerra Ojeda S, Verdu D, Valls A, Arc-Chagnaud C, De la Rosa A, Vina J. International Journal of Molecular Sciences. 2023 Feb 11;24(4):3622. doi: 10.3390/ijms24043622. PMID: 36835034

Mild cognitive impairment is associated with enhanced activation of Th17 lymphocytes in non-alcoholic fatty liver disease. Fiorillo A, Gallego J, Casanova-Ferrer F, Gimenez-Garzo C, Urios A, Ballester M, Durban L, Rios M, Megias J, San Miguel T, Kosenko E, Escudero-Garcia D, Benlloch S, Felipo V, Montoliu C. International Journal of Molecular Sciences. 2023 Jun 20;24(12):10407. doi: 10.3390/ijms241210407. PMID: 37373554

A pigmented nodule on congenital melanocytic nevus: challenge. Sabater Marco V, Cervero L, Losada L, Lopez N. American Journal of Dermatopathology. 2022 Oct 1;44(10):e108-e109. doi: 10.1097/DAD.0000000000002265. PMID: 36122342

Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation. Megias J, San-Miguel T, Sanchez M, Navarro L, Monleon D, Calabuig-Farinas S, Morales J, Munoz-Hidalgo L, Roldan P, Cerda-Nicolas M, Lopez-Gines C. Acta Neuropathologica Communications. 2022 Jun 20;10(1):88. doi: 10.1186/s40478-022-01392-x. PMID: 35725578

Matched paired primary and recurrent meningiomas points to cell-death program contributions to genomic and epigenomic instability along tumor progression. San-Miguel T, Megias J, Monleon D, Navarro L, Munoz-Hidalgo L, Montoliu C, Meri M, Roldan P, Cerda-Nicolas M, Lopez-Gines C. Cancers. 2022 Aug 19;14(16):4008. doi: 10.3390/cancers14164008. PMID: 36011000

Metabolic syndrome is associated with poor response to rifaximin in minimal hepatic encephalopathy. Ballester M, Gallego J, Fiorillo A, Casanova-Ferrer F, Gimenez-Garzo C, Escudero-Garcia D, Tosca J, Rios M, Monton C, Durban L, Ballester J, Benlloch S, Urios A, San-Miguel T, Kosenko E, Serra M, Felipo V, Montoliu C. Scientific Reports. 2022 Feb 14;12(1):2463. doi: 10.1038/s41598-022-06416-z. PMID: 35165326

Plasma extracellular vesicles play a role in immune system modulation in minimal hepatic encephalopathy. Gallego J, Fiorillo A, Casanova-Ferrer F, Urios A, Ballester M, Durban L, Megias J, Rubio T, Cabrera-Pastor A, Escudero-Garcia D, Felipo V, Montoliu C. International Journal of Molecular Sciences. 2022 Oct 15;23(20):12335. doi: 10.3390/ijms232012335. PMID: 36293192

A new score unveils a high prevalence of mild cognitive impairment in patients with nonalcoholic fatty liver disease. Gimenez-Garzo C, Fiorillo A, Ballester-Ferre M, Gallego J, Casanova-Ferrer F, Urios A, Benlloch S, Marti-Aguado D, San-Miguel T, Tosca J, Rios M, Monton C, Durban L, Escudero-Garcia D, Aparicio L, Felipo V, Montoliu C. Journal of Clinical Medicine. 2021 Jun 25;10(13):2806. doi: 10.3390/jcm10132806. PMID: 34202269

Cytocompatibility and bioactive properties of the new dual-curing resin-modified calcium silicate-based material for vital pulp therapy. Rodriguez-Lozano F, Lopez-Garcia S, Garcia-Bernal D, Sanz J, Lozano A, Pecci-Lloret M, Melo M, Lopez-Gines C, Forner L. Clinical Oral Investigations. 2021 Aug;25(8):5009-5024. doi: 10.1007/s00784-021-03811-0. PMID: 33638052

Dental stem cell signaling pathway activation in response to hydraulic calcium silicate-based endodontic cements: A systematic review of in vitro studies. Sanz J, Rodriguez-Lozano F, Lopez-Gines C, Monleon D, Llena C, Forner L. Dental materials. 2021 Apr;37(4):e256-e268. doi: 10.1016/ PMID: 33573840

Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function. Rega D, Aiko M, Penaranda N, Urios A, Gallego J, Gimenez-Garzo C, Casanova F, Fiorillo A, Cabrera-Pastor A, San-Miguel T, Ipiens C, Escudero-Garcia D, Tosca J, Monton C, Ballester M, Ballester J, Aparicio L, Rios M, Durban L, Mir A, Kosenko E, Cases P, Felipo V, Montoliu C. Journal of Clinical Medicine. 2021 Jan 11;10(2):E239. doi: 10.3390/jcm10020239. PMID: 33440769

PPARgamma as an indicator of vascular function in an experimental model of metabolic syndrome in rabbits. Guerra-Ojeda S, Marchio P, Gimeno-Raga M, Arias-Mutis O, San-Miguel T, Valles S, Aldasoro M, Vila J, Zarzoso M, Mauricio M. Atherosclerosis. 2021 Aug 5;332:16-23. doi: 10.1016/j.atherosclerosis.2021.08.006. PMID: 34375909

Whole-exome sequencing, EGFR amplification and infiltration patterns in human glioblastoma. Lopez-Gines C, Munoz-Hidalgo L, San-Miguel T, Megias J, Trivino J, Calabuig S, Roldan P, Cerda-Nicolas M, Monleon D. American Journal of Cancer Research. 2021 Nov 15;11(11):5543-5558. PMID: 34873478‘ target=’_blank’>34873478

Circulating miRNA expression analysis reveals new potential biomarkers for human cutaneous melanoma staging. Sanchez Sendra B, Garcia Gimenez J, González Muñoz J, Navarro Cerveró L, Murgui A, Terradez Mas L, Pinazo Canales M, Martin Hernandez J, Monteagudo Castro C. Journal of the European Academy of Dermatology and Venereology. 2020 Mar;34(3):e126-e129. doi: 10.1111/jdv.16060. PMID: 31710393

Dectin-1 stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward trained macrophages via an indirect cell-autonomous mechanism. Bono C, Martinez A, Megias J, Gozalbo D, Yanez A, Gil ML. MBIO. 2020 Jun 23;11(3):e00781-20. doi: 10.1128/mBio.00781-20. PMID: 32576672

Identification of a Novel BRCA1 Alteration in Recurrent Melanocytoma Resulting in Increased Proliferation. San Miguel Diez T, Navarro Cerveró L, Sanchez Sendra B, Megias Vericat J, Muñoz Hidalgo L, Santonja Lopez N, Lopez Gines C, Cerda Nicolas M. Journal of Neuropathology and Experimental Neurology. 2020 Nov 1;79(11):1233-1238. doi: 10.1093/jnen/nlaa089. PMID: 32974655

Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis. Navarro Cerveró L, San Miguel Diez T, Megias Vericat J, Santonja Lopez N, Calabuig S, Muñoz Hidalgo L, Roldan Badia P, Cerda Nicolas M, Lopez Gines C. Cells. 2020 Nov 6;9(11):2429. doi: 10.3390/cells9112429. PMID: 33172155

Pam3CSK4, a TLR2 ligand, induces differentiation of glioblastoma stem cells and confers susceptibility to temozolomide. Megias Vericat J, Martinez A, San Miguel Diez T, Gil Benso R, Muñoz Hidalgo L, Albert-Bellver D, Carratala A, Gozalbo D, Lopez Gines C, Gil M, Cerda Nicolas M. Investigational New Drugs. 2020 Apr;38(2):299-310. doi: 10.1007/s10637-019-00788-2. PMID: 31076963

Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma. Muñoz Hidalgo L, San Miguel Diez T, Megias Vericat J, Monleon Salvado D, Navarro Cerveró L, Roldan Badia P, Cerda Nicolas M, Lopez Gines C. Neoplasia. 2020 Jan;22(1):10-21. doi: 10.1016/j.neo.2019.09.001. PMID: 31751860

The Status of EGFR Modulates the Effect of miRNA-200c on ZEB1 Expression and Cell Migration in Glioblastoma Cells. Munoz-Hidalgo L, San-Miguel T, Megias J, Serna E, Calabuig-Farinas S, Monleon D, Gil-Benso R, Cerda-Nicolas M, Lopez-Gines C. International Journal of Molecular Sciences. 2020 Dec 31;22(1):368. doi: 10.3390/ijms22010368. PMID: 33396457

Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma. Sanchez Sendra B, Serna García E, Navarro Cerveró L, González Muñoz J, Portero Trigo J, Ramos Jarero A, Murgui Faubel A, Monteagudo Castro C. Scientific Reports. 2020 Mar 16;10(1):4771. doi: 10.1038/s41598-020-61637-4. PMID: 32179834

Reference: PID2021-125485NB-C21
Title: Astrofísica computacional y análisis de datos
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Pablo Cerdá Durán
Duration: 2022 – 2025
Total budget: 207.000 €
Reference: AP-2021-001
Title: LIGAM1: Efecto de la activación de TLR por medio de sus ligandos sobre la polarización de macrófagos hacia M1 y su función citocida frente a las células madre de glioblastoma
Funding body: Universidad de Valencia – INCLIVA
Principal Investigator: Javier Megías Vericat, Andrea Cabrera Pastor
Duration: 2021 – 2022
Total budget: 4.608 €
Reference: GV/2020/048
Title: Estudio de la angiogénesis en el glioblastoma y su asociación con inflamación y agresividad en tumores humanos y en cultivo in vitro. Introducción a la patología
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Teresa San Miguel Díez
Duration: 2020 – 2021
Total budget: 12.420 €
+ Info
Title: Role of hematopoietic stem and progenitor cells in training immunity against infection
Doctoral candidate: Bono Tapp, Cristina
Director(s): Gil Herrero, María Luisa; Yáñez Boyer, Alberto; Megías Vericat, Javier
Date of the defense: 10/02/2023
University: Universitat de València

Title: Patrones de amplificación de egfr en el glioblastoma, e identificación de biomarcadores implicados en sus principales vías de señalización
Doctoral candidate: Navarro Cerveró, Lara
Director(s): Cerdá Nicolás, Miguel; López Giner, Concepción
Date of the defense: 28/10/2022
University: Universitat de València

Title: Biocompatibilidad y bioactividad de nuevos materiales para odontologia regenerativa
Doctoral candidate: Rodríguez Lozano, Francisco Javier
Director(s): Forner Lozano, Leopoldo; Llena Puy, María del Carmen; López Gines, Concepción
Date of the defense: 03/12/2021
University: Universitat de València

Title: Dynamics in the magnetospheres of compact objects
Doctoral candidate: Mahlmann, Jens Florian
Director(s): Aloy Toras, Miguel Ángel; Cerdá Durán, Pablo
Date of the defense: 22/07/2020
University: Universitat de València