Dr. Aymara Mas Perucho

Emerging Investigator
Research Group on Reproductive Medicine

Presentation

Dr. Aymara Mas is a Senior Principal Investigator at the Carlos Simón Foundation and a Miguel Servet Researcher (ISCIII) at the INCLIVA Health Research Institute in Valencia.

Her research focuses on understanding the factors that contribute to the physiopathology of gynecological tumors that develop primarily in the myometrium and ovary.
Dr. Mas completed a 2-year international postdoctoral fellowship at Augusta University (Georgia, USA), which she completed at the La Fe Health Research Institute in Valencia with a Sara Borrell Grant (ISCIII), studying primarily uterine disorders.

Over the past 10 years, she has made significant contributions, such as proof of functional concept regarding the existence of somatic stem cells (CME) in the human myometrium and uterine leiomyomas (PMID: 24890270) based on side population methods (PMID: 22633281) and specific biomarkers (PMID: 25989979; PMID: 28395335). She has also collaborated with numerous groups to study the role of steroid hormone receptors (PMID: 27739139), signaling pathways (PMID: 30075150), and genetic (PMID: 25542836) and epigenetic (PMID: 25922306) alterations in the pathogenesis and growth of uterine leiomyomas, deepening new approaches to improve the efficacy of gene therapy against these benign tumors (PMID: 27020169). She has also revealed, through integrative genomic and transcriptomic profiling, the differential molecular signature of uterine leiomyomas versus leiomyosarcomas (PMID: 31121144; PMID: 35216305), leading to 2 patent applications.

Her commitment to research excellence is demonstrated by an established track record of 9 research projects (5 as principal investigator) and 32 basic and translational publications in peer-reviewed journals, with an average of 36.19 citations/publication. She has participated in national and international conferences and has been awarded internationally by the Society of Reproductive Investigation (SRI) and the American Society of Reproductive Medicine (ASRM). She also mentors medical students in their final year projects and doctoral students.

Currently, her team is using high-throughput sequencing technologies to identify molecular biomarkers associated with tumor growth and progression, in order to develop predictive models that will enable non-invasive therapeutic and preventive strategies.

Emerging
Investigator

amas@incliva.es