Grupo de Investigación en Trasplante Hematopoyético

Área de Oncología

Investigación traslacional sobre biología y tratamiento de la enfermedad injerto contra huésped tras trasplante alogénico de células progenitoras hematopoyéticas

Infección y reconstitución inmunitaria tras trasplante hematopoyético

Desarrollo de un programa de Terapias Avanzadas- clínico y traslacional en el Hospital Clínico Universitario de Valencia – INCLIVA

Diseño e implementación de un programa ambulatorio en trasplante hematopoyético y terapia celular

Dr. Carlos Solano Vercet
Coordinador
Dr. Carlos Solano Vercet
carlos.solano@uv.es

INVESTIGADORES
R4 Senior

Carlos Solano Vercet    

R3 Consolidado

Jose Luis Piñana Sánchez

R2 Novel / Emergente

Mª José Remigia Pellicer
Paula Amat Martínez
Rafael Hernani Morales

R1 Predoctoral

Ariadna Pérez Martínez
Rut Meseguer Naturil

STAFF
Colaborador/a

Ana Benzaquen Vallejos
Rosa Goterris Viciedo

Enfermero/a

Elisa Núñez Biota
Julia Carrió Fito
Marina Hernández Aliaga

Técnico/a

Ana Riera Calabuig
Clara Seherazade Osca Gómez
Diana Campos Beltrán
Francisca Fernández Olmo
Mª Pilar Ortiz Gavilán
Vicent Cuevas Mauricio

Apoyo
Publicaciones
Adoptive immunotherapy via donor lymphocyte infusions following allogeneic hematopoietic stem cell transplantation for myelofibrosis: a real-world, retrospective multicenter study. Rampotas A, Sockel K, Panitsas F, Theuser C, Bornhauser M, Hernani R, Hernandez-Boluda JC, Esquirol A, Avenoso D, Tsirigotis P, Robin M, Czerw T, Helbig G, Roddie C, Lambert J, McLornan DP. Transplantation and Cellular Therapy. 2023 Nov;29(11):687.e1-687.e7. doi: 10.1016/j.jtct.2023.08.020. PMID: 37633414

Anakinra for refractory CRS or ICANS after CAR T-cell therapy. Gazeau N, Liang E, Wu Q, Voutsinas J, Barba P, Iacoboni G, Kwon M, Ortega J, Lopez-Corral L, Hernani R, Ortiz-Maldonado V, Martinez-Cibrian N, Martinez A, Maziarz R, Williamson S, Nemecek E, Shadman M, Cowan A, Green D, Kimble E, Hirayama A, Maloney D, Turtle C, Gauthier J. Transplantation and Cellular Therapy. 2023 Jul;29(7):430-437. doi: 10.1016/j.jtct.2023.04.001. PMID: 37031746

Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: a proof-of-concept study. de la Asunción C, Giménez E, Hernández-Boluda J, Terol M, Albert E, López J, García-Gutiérrez V, Andreu R, Malo M, Fox M, Remigia M, Amat P, Solano C, Navarro D. Journal of Medical Virology. 2023 Jul;95(7):e28933. doi: 10.1002/jmv.28933. PMID: 37403897

Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma. Kwon M, Iacoboni G, Reguera JL, Lopez Corral L, Hernani Morales R, Ortiz-Maldonado V, Guerreiro M, Caballero AC, Guerra Dominguez ML, Sanchez Pina JM, Mussetti A, Sancho JM, Bastos-Oreiro M, Catala E, Delgado J, Henriquez HL, Sanz J, Calbacho M, Bailen R, Carpio C, Ribera JM, Sureda A, Briones J, Hernandez-Boluda JC, Martinez Cebrian N, Diez Martin JL, Martin A, Barba P. Haematologica. 2023 Jan 1;108(1):110-121. doi: 10.3324/haematol.2022.280805. PMID: 35770532

Correction: Role of allogeneic hematopoietic cell transplant for relapsed/refractory aggressive B-cell lymphomas in the CART era. Mussetti A, Bento L, Bastos-Oreiro M, Rius-Sansalvador B, Albo C, Bailen R, Barba P, Benzaquén A, Briones J, Caballero AC, Campos A, Español I, Ferra C, López SG, González Sierra PA, Guerra LM, Hernani R, Iacoboni G, Jiménez-Ubieto A, Kwon M, Corral LL, López-Godino O, Munoz MCM, Martínez-Cibrián N, Gómez JM, Pérez-Ortega L, Ortí G, Ortiz-Maldonado V, Pascual MJ, Perera M, Perez A, Reguera JL, Sanchez JM, Sanz J, Torrent A, Yáñez L, Varela R, Echechipia IC, Caballero D, Sureda A. Bone Marrow Transplantation. 2023 Jun;58(6):738. doi: 10.1038/s41409-023-01967-9. PMID: 37076611

Cytomegalovirus DNAemia in hematological patients undergoing CD19-directed CAR-T cell therapy: should it be systematically monitored?. Solano de la Asuncion C, Hernani R, Albert E, Gomez M, Gimenez E, Benzaquen A, Gonzalez-Barbera E, Hernandez-Boluda J, Perez A, Pinana J, Chorao P, Guerreiro M, Montoro J, Sanz J, Solano C, Navarro D. Clinical Microbiology and Infection. 2023 Aug;29(8):1093-1095. doi: 10.1016/j.cmi.2023.05.010. PMID: 37182642

Disseminated toxoplasma infection after hematopoietic stem cell transplantation with myositis and encephalitis. Asensi Canto P, Mayordomo E, Dorado A, Villalba M, Manez R, Gonzalez E, Salavert M, Facal A, Chorao P, Balaguer A, Sivera R, Montoro J, Vilchez J, Pinana J, Sanz M, Sanz J, Muelas N, Guerreiro M. Transplant Infectious Disease. 2023 Aug;25(4):e14067. doi: 10.1111/tid.14067. PMID: 37177901

Features of cytomegalovirus DNAemia and virus-specific T-cell responses in allogeneic hematopoietic stem-cell transplant recipients during prophylaxis with letermovir. Gimenez E, Guerreiro M, Torres I, Aguilar C, Albert E, Hernandez-Boluda JC, Hernani R, Perez A, Amat P, Pinana JL, Montoro J, Solano C, Navarro D. Transplant Infectious Disease. 2023 Apr;25(2):e14021. doi: 10.1111/tid.14021. PMID: 36748748

Identifying early infections in the setting of CRS with routine and exploratory serum proteomics and the HT10 score following CD19 CAR-T for relapsed/refractory B-NHL. Rejeski K, Blumenberg V, Iacoboni G, Lopez-Corral L, Kharboutli S, Hernani R, Petrera A, Muller N, Hildebrand F, Frolich L, Karschnia P, Schmidt C, Cordas Dos Santos D, Pinana J, Muller F, Martin A, Dreyling M, von Bergwelt-Baildon M, Barba P, Subklewe M, Bucklein V. Hemasphere. 2023 Apr 5;7(4):e858. doi: 10.1097/HS9.0000000000000858. PMID: 37038465

Immunobiology of cytomegalovirus infection in patients with haematological malignancies undergoing treatment with small molecule inhibitors. Solano De la Asuncion C, Gimenez E, Hernandez-Boluda JC, Terol MJ, Albert E, Lopez-Jimenez J, Garcia-Gutierrez V, Andreu R, Garcia D, Fox ML, Remigia MJ, Amat P, Solano C, Navarro D. British Journal of Haematology. 2023 Mar;200(6):e58-e61. doi: 10.1111/bjh.18655. PMID: 36652997

Impact of cytomegalovirus immunodominant HLA-I donor-recipient matching on the incidence and features of virus DNAemia and virus-specific T-cell immune reconstitution in unmanipulated haploidentical hematopoietic stem cell transplantation. Huntley D, Gimenez E, Vazquez L, Pascual M, Amat P, Remigia M, Hernandez-Boluda J, Garcia M, Gago B, Torres I, de la Asuncion C, Hernani R, Perez A, Albert E, Pinana J, Solano C, Navarro D. Transplant Infectious Disease. 2023 Jun;25(3):e14065. doi: 10.1111/tid.14065. PMID: 37120821

Impact of SCHOLAR-1 criteria on CAR-T cell therapy efficacy in aggressive B lymphoma. A real-world GELTAMO/GETH study. Oreiro M, Gutierrez A, Iacoboni G, Corral L, Reguera J, Abrisqueta P, Delgado J, Terol M, Hernani R, Martinez N, Ortiz V, Bailen R, Gomez-Centurion I, Caballero A, Sanz J, Dominguez L, Hugo L, Musseti A, Ubieto A, Sancho J, Sureda A, Perez A, Barba P, Kwon M, Garcia-Sancho A. Transplantation And Cellular Therapy. 2023 Aug 31;S2666-6367(23)01508-7. doi: 10.1016/j.jtct.2023.08.026. PMID: 37659694

Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry. Ljungman P, Tridello G, Pinana J, Ciceri F, Sengeloev H, Kulagin A, Mielke S, Yegin Z, Collin M, Einardottir S, Lepretre S, Maertens J, Campos A, Metafuni E, Pichler H, Folber F, Solano C, Nicholson E, Yuksel M, Carlson K, Aguado B, Besley C, Byrne J, Heras I, Dignan F, Kroger N, Robin C, Khan A, Lenhoff S, Grassi A, Dobsinska V, Miranda N, Jimenez M, Yonal-Hindilerden I, Wilson K, Averbuch D, Cesaro S, Xhaard A, Knelange N, Styczynski J, Mikulska M, de la Camara R. Frontiers in Immunology. 2023 Mar 7;14:1125824. doi: 10.3389/fimmu.2023.1125824. PMID: 36960069

In vitro assessment of the combined effect of letermovir and sirolimus on cytomegalovirus replication. Gimenez E, Guerreiro M, Gozalbo-Rovira R, Aguilar C, Albert E, Pinana J, Solano C, Navarro D. Revista Espanola de Quimioterapia. 2023 Oct;36(5):526-530. doi: 10.37201/req/016.2023. PMID: 37365797

Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion. Martin Castillo I, Villamon Ribate E, Calabuig Munoz M, Sanz Santillana G, Such Taboada E, Mora Castera E, Calasanz Abinzano MJ, Irigoyen Barranco A, Collado Nieto R, Vara Pampliega M, Blanco ML, Alvarez de Andres S, Perez de Oteyza J, Bernal del Castillo T, Granada Font I, Jerez Cayuela A, Diez-Campelo M, Abellan Sanchez R.; Solano Vercet C, Tormo Diaz M. Cancer Medicine. 2023 Aug;12(16):16788-16792. doi: 10.1002/cam4.6300. PMID: 37403747

Low rate of infectious enterocolitis in allogeneic stem cell transplant recipients with acute diarrhea: a prospective study by the GETH-TC. Velao S, Cadenas I, Cuesta M, Sanchez-Ortega I, Fernandez-Aviles F, Roldan E, Torrent A, Viguria M, Villar S, Bento L, Yanez L, Martino R, Pinana J. Acta Haematologica. 2023;146(2):161-165. doi: 10.1159/000528242. PMID: 36446336

Monitoring for virus-specific T-cell responses and viremia in allogeneic HSCT recipients: a survey from the EBMT Cellular Therapy & Immunobiology Working Party. Greco R, Hoogenboom JD, Bonneville EF, Anagnostopoulos A, Cuoghi A, Dalle JH, Weissinger EM, Lang P, Galaverna F, Martino M, Maschan A, Mauz-Korholz C, Noviello M, Passweg J, Peccatori J, Rovira M, Solano C, Veelken H, Velardi A, Wagner-Drouet EM, Zhang X, Ciceri F, Bonini C, Vago L, Ruggeri A, Chabannon C. Bone Marrow Transplantation. 2023 May;58(5):603-606. doi: 10.1038/s41409-023-01939-z. PMID: 36813866

Monitoring of plasma Torque teno virus, total Anelloviridae and Human Pegivirus 1 viral load for the prediction of infectious events and acute graft versus host disease in the allogeneic hematopoietic stem cell transplantation setting. Forqué L, Albert E, Piñana JL, Pérez A, Hernani R, Solano C, Navarro D, Giménez E. Journal of Medical Virology. 2023 Sep;95(9):e29107. doi: 10.1002/jmv.29107. PMID: 37721473

One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients. Pinana JL, Vazquez L, Calabuig M, Lopez-Corral L, Martin-Martin G, Villalon L, Sanz-Linares G, Conesa-Garcia V, Sanchez-Salinas A, Gago B, Facal A, Risco-Galvez I, Olave MT, Espigado I, Lopez-Jimenez J, Hernandez-Rivas JA, Avendano-Pita A, Arroyo I, Ferrer E, Garcia-Cadenas I, Gonzalez-Santillana C, Roldan-Perez A, Ferrer B, Guerreiro M, Suarez-Lledo M, Camara A, Campos-Beltran D, Navarro D, Cedillo A, Sureda A, Solano C, Martino R. Blood Cancer Journal. 2023 Jan 5;13(1):8. doi: 10.1038/s41408-022-00778-3. PMID: 36599843

Performance of the beta-glucan test for the diagnosis of invasive fusariosis and scedosporiosis: a meta-analysis. Lamoth F, Nucci M, Fernandez-Cruz A, Azoulay E, Lanternier F, Bremerich J, Einsele H, Johnson E, Lehrnbecher T, Mercier T, Porto L, Verweij P, White L, Maertens J, Alanio A. Medical Mycology. 2023 Jul 6;61(7):myad061. doi: 10.1093/mmy/myad061. PMID: 37381179

Recent bendamustine treatment before apheresis has a negative impact on outcomes in patients with large B-Cell lymphoma receiving chimeric antigen receptor t-cell therapy. Iacoboni G, Navarro V, Martín-López AÁ, Rejeski K, Kwon M, Jalowiec KA, Amat P, Reguera-Ortega JL, Gallur L, Blumenberg V, Gutiérrez-Herrero S, Roddie C, Benzaquén A, Delgado-Serrano J, Sánchez-Salinas MA, Bailén R, Carpio C, López-Corral L, Hernani R, Bastos M, O’Reilly M, Martín-Martín L, Subklewe M, Barba P. Journal of Clinical Oncology. 2023 Oct 24:JCO2301097. doi: 10.1200/JCO.23.01097. PMID: 37874957

Recommendations on the use of azole antifungals in hematology-oncology patients. Azanza J, Mensa J, Barberan J, Vazquez L, Perez de Oteyza J, Kwon M, Yanez L, Aguado J, Cubillo Gracian A, Ruiz Camps I, Fortun J, Salavert Lleti M, Gudiol C, Olave Rubio T, Solano C, Garcia-Vidal C, Rovira Tarrats M, Suarez-Lledo Grande M, Gonzalez-Sierra P, Duenas Gutierrez C. Revista Espanola de Quimioterapia. 2023 Jun;36(3):236-258. doi: 10.37201/req/013.2023. PMID: 37017117

Respiratory virus infections after allogeneic stem cell transplantation: Current understanding, knowledge gaps, and recent advances. Pinana J, Perez A, Chorao P, Guerreiro M, Garcia-Cadenas I, Solano C, Martino R, Navarro D. Transplant Infectious Disease. 2023 Aug 16;e14117. doi: 10.1111/tid.14117. PMID: 37585370

Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period: a prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study. Averbuch D, de la Camara R, Tridello G, Knelange N, Bykova T, Ifversen M, Dobsinska V, Ayas M, Hamidieh A, Pichler H, Perez Martinez A, Cesaro S, Sundin M, Badell I, Bader P, Johansson J, Mirci Danicar O, Sedlacek P, Paillard C, Gibson B, Lawson S, Kroeger N, Corbacioglu S, Mikulska M, Pinana J, Styczynski J, Ljungman P. Bone Marrow Transplantation. 2023 Feb 27;1-9. doi: 10.1038/s41409-023-01941-5. PMID: 36849806

Role of allogeneic hematopoietic cell transplant for relapsed/refractory aggressive B-cell lymphomas in the CART era. Mussetti A, Bento L, Bastos-Oreiro M, Rius Sansalvador B, Albo C, Bailen R, Barba P, Benzaquen A, Briones J, Caballero A, Campos A, Espanol I, Ferra C, Lopez S, Gonzalez Sierra P, Guerra L, Hernani R, Iacoboni G, Jiminez Ubieto A, Kwon M, Corral L, Lopez Godino O, Munoz M, Martinez Cibrian N, Gomez J, Perez Ortega L, Orti G, Ortiz Maldonado V, Pascual M, Perera M, Perez A, Reguera J, Sanchez J, Sanz J, Torrent A, Yanez L, Varela R, Echechipia I, Caballero D, Sureda A. Bone Marrow Transplantation. 2023 Jun;58(6):673-679. doi: 10.1038/s41409-023-01949-x. PMID: 36918682

SARS-CoV-2-reactive antibody waning, booster effect and breakthrough SARS-CoV-2 infection in hematopoietic stem cell transplant and cell therapy recipients at one year after vaccination. Pinana J, Martino R, Vazquez L, Lopez-Corral L, Perez A, Chorao P, Avendano Pita A, Pascual M, Sanchez Salinas A, Sanz Linares G, Olave M, Arroyo I, Tormo M, Villalon L, Conesa Garcia V, Gago B, Terol M, Villalba M, Garcia Gutierrez V, Cabero A, Hernandez Rivas J, Ferrer E, Garcia Cadenas I, Teruel A, Navarro D, Cedillo A, Sureda A, Solano C. Bone Marrow Transplantation. 2023 Feb 28;1-14. doi: 10.1038/s41409-023-01946-0. PMID: 36854892

Torque Teno Virus plasma DNA load: a novel prognostic biomarker in CAR-T therapy. Benzaquén A, Giménez E, Iacoboni G, Guerreiro M, Hernani R, Albert E, Carpio C, Balaguer A, Pérez A, S de la Asunción C, Sánchez-Salinas MA, Chorão P, Piñana JL, Beas F, Montoro J, Hernández-Boluda JC, Facal A, Ferrer B, Villalba M, Amat P, Goméz MD, Campos D, Terol MJ, Sanz J, Barba P, Navarro D, Solano C. Bone Marrow Transplantation. 2023 Nov 2. doi: 10.1038/s41409-023-02114-0. PMID: 37919456

Upper and/or lower respiratory tract infection caused by human metapneumovirus after allogeneic hematopoietic stem cell transplantation. Piñana JL, Tridello G, Xhaard A, Wendel L, Montoro J, Vazquez L, Heras I, Ljungman P, Mikulska M, Salmenniemi U, Perez A, Kröger N, Cornelissen JJ, Sala E, Martino R, Geurten C, Byrne J, Maertens J, Kerre T, Martin M, Pascual MJ, Yeshurun M, Finke J, Groll AH, Shaw PJ, Blijlevens N, Arcese W, Ganser A, Suarez-Lledo M, Alzahrani M, Choi G, Forcade E, Paviglianiti A, Solano C, Wachowiak J, Zuckerman T, Bader P, Clausen J, Mayer J, Schroyens W, Metafuni E, Knelange N, Averbuch D, de la Camara R. The Journal of Infectious Diseases. 2023 Jul 13;jiad268. doi: 10.1093/infdis/jiad268. PMID: 37440459

Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): results of a retrospective multicenter study from GELTAMO/GETH-TC Spanish Groups. Rey-Bua B, Cabrero M, Bento L, Montoro J, Bastos-Oreiro M, Parody R, Yanez L, Lopez-Godino O, Zanabili J, Herrera P, Gutierrez G, Perez A, Pinana J, Novelli S, Cortes M, Sureda A, Caballero D, Garcia-Sancho A. Cancers. 2022 Nov 18;14(22):5670. doi: 10.3390/cancers14225670. PMID: 36428762

Allogeneic stem cell transplantation in mantle cell lymphoma; insights into its potential role in the era of new immunotherapeutic and targeted therapies: the GETH/GELTAMO experience. Gutierrez A, Bento L, Novelli S, Martin A, Gutierrez G, Salas M, Bastos-Oreiro M, Perez A, Hernani R, Viguria M, Lopez-Godino O, Montoro J, Pinana J, Ferra C, Parody R, Martin C, Espanol I, Yanez L, Rodriguez G, Zanabili J, Herrera P, Varela M, Sampol A, Solano C, Caballero D. Cancers. 2022 May 27;14(11):2673. doi: 10.3390/cancers14112673. PMID: 35681653

Applicability of probabilistic graphical models for early detection of SARS-CoV-2 reactive antibodies after SARS-CoV-2 vaccination in hematological patients. Pinana J, Rodriguez-Belenguer P, Caballero D, Martino R, Lopez-Corral L, Terol M, Vazquez L, Calabuig M, Sanz-Linares G, Marin-Jimenez F, Alonso C, Montoro J, Ferrer E, Facal A, Pascual M, Rodriguez-Fernandez A, Olave M, Cascales-Hernandez A, Gago B, Hernandez-Rivas J, Villalon L, Corona M, Roldan-Perez A, Ribes-Amoros J, Gonzalez-Santillana C, Garcia-Sanz R, Navarro D, Serrano-Lopez A, Cedillo A, Soria-Olivas E, Sureda A, Solano C. Annals of Hematology. 2022 Sep;101(9):2053-2067. doi: 10.1007/s00277-022-04906-8. PMID: 35780254

Best treatment option for patients with refractory aggressive b-cell lymphoma in the car-t cell era: real-world evidence from GELTAMO/GETH Spanish Groups. Bastos-Oreiro M, Gutierrez A, Reguera J, Iacoboni G, Lopez-Corral L, Terol M, Ortiz-Maldonado V, Sanz J, Guerra-Dominguez L, Bailen R, Mussetti A, Abrisqueta P, Hernani R, Luzardo H, Sancho J, Delgado-Serrano J, Salar A, Grande C, Bento L, de Villambrosia S, Garcia-Belmonte D, Sureda A, Perez-Martinez A, Barba P, Kwon M, Garcia-Sancho A. Frontiers in Immunology. 2022 Jul 12;13:855730. doi: 10.3389/fimmu.2022.855730. PMID: 35911769

Booster effect after SARS-CoV-2 vaccination in immunocompromised hematology patients with prior COVID-19. Piñana JL, Garcia-Sanz R, Martino R, Garcia-Roa M, Martin-Martin GA, Risco-Gálvez I, Tormo M, Martinez-Barranco P, Marcos-Corrales S, Calabuig M, Conesa V, Teruel A, Ruiz-Pérez S, Solano C, Navarro D, Cedillo Á, Sureda A. Blood Advances. 2022 Jan 8;6(3):848-853. doi: 10.1182/bloodadvances.2021006326. PMID: 34905620

Evolution of SARS-CoV-2 immune responses in nursing home residents following full dose of the Comirnaty COVID-19 vaccine. Gimenez E, Alberola J, Torres I, Albert E, Alcaraz MJ, Botija P, Amat P, Remigia MJ, Beltran MJ, Rodado C, Huntley D, Olea B, Navarro D. Journal of Infection. 2022 Mar;84(3):418-467. doi: 10.1016/j.jinf.2021.10.026. PMID: 34740744

HEV infection in stem cell transplant recipients-retrospective study of EBMT Infectious Diseases Working Party. Mikulska M, Penack O, Wendel L, Knelange N, Cornelissen J, Blijlevens N, Passweg J, Kroger N, Bruns A, Koenecke C, Bierings M, Pinana J, Labussiere-Wallet H, Ghesquieres H, Diaz M, Sampol A, Averbuch D, de la Camara R, Styczynski J. Bone Marrow Transplantation. 2022 Feb;57(2):167-175. doi: 10.1038/s41409-021-01497-2. PMID: 34689177

Human genetic polymorphisms and risk of viral infection after solid organ transplantation. Redondo N, Navarro D, Aguado JM, Fernandez-Ruiz M. Transplantation Reviews. 2022 Jan;36(1):100669. doi: 10.1016/j.trre.2021.100669. PMID: 34688126

Identifying SARS-CoV-2 ‘memory’ NK cells from COVID-19 convalescent donors for adoptive cell therapy. Herrera L, Martin-Inaraja M, Santos S, Ingles-Ferrandiz M, Azkarate A, Perez-Vaquero MA, Vesga MA, Vicario JL, Soria B, Solano C, De Paz R, Marcos A, Ferreras C, Perez-Martinez A, Eguizabal C. Immunology. 2022 Feb;165(2):234-249. doi: 10.1111/imm.13432. doi: 10.1111/imm.13432. PMID: 34775592

Multi-body-site colonization screening cultures for predicting multi-drug resistant Gram-negative and Gram-positive bacteremia in hematological patients. Torres I, Huntley D, Tormo M, Calabuig M, Hernandez-Boluda J, Terol M, Carretero C, de Michelena P, Perez A, Pinana J, Colomina J, Solano C, Navarro D. BMC Infectious Diseases. 2022 Feb 21;22(1):172. doi: 10.1186/s12879-022-07154-3. PMID: 35189833

Post-transplant cyclophosphamide after HLA identical compared to Haploidentical donor transplant in Acute Myeloid Leukemia: a study on behalf of GETH-TC. Bailen R, Pascual-Cascon M, Guerreiro M, Lopez-Corral L, Chinea A, Bermudez A, Sampol A, Heras I, Garcia-Torres E, Torres M, Roca J, Herruzo B, Sanz J, Fonseca M, Herrera P, Colorado M, Bento L, Lopez-Godino O, Martin-Calvo C, Fernandez-Caldas P, Marcos-Jubilar M, Sanchez-Ortega I, Solano C, Noriega V, Humala K, Oarbeascoa G, Jose Luis Diez-Martin J, Kwon M, Grupo Espanol de Trasplante Hematopoyetico y Terapia Celular (GETH). Transplantation and Cellular Therapy. 2022 Apr;28(4):204.e1-204.e10. doi: 10.1016/j.jtct.2022.01.020. PMID: 35108627

Post-transplant cyclophosphamide and sirolimus based graft-versus-host disease prophylaxis after allogeneic stem cell transplantation for acute myeloid leukemia. Lazzari L, Balaguer-Rosello A, Montoro J, Greco R, Hernani R, Lupo-Stanghellini M, Villalba M, Giglio F, Facal A, Lorentino F, Guerreiro M, Bruno A, Perez A, Xue E, Clerici D, Piemontese S, Pinana J, Sanz M, Solano C, de la Rubia J, Ciceri F, Peccatori J, Sanz J. Bone Marrow Transplantation. 2022 Sep;57(9):1389-1398. doi: 10.1038/s41409-022-01725-3. PMID: 35680995

Real-world effectiveness of caplacizumab vs standard of care in immune thrombotic thrombocytopenic purpura. Pascual Izquierdo M, Mingot-Castellano M, Kerguelen Fuentes A, Garcia-Arroba Peinado J, Cid J, Jimenez M, Valcarcel D, Gomez-Segui I, de la Rubia J, Martin P, Goterris R, Hernandez-Mateo L, Tallon Ruiz I, Varea S, Fernandez-Docampp M, Garcia-Munoz N, Vara M, Fernandez Zarzoso M, Garcia-Candel F, Paciello M, Garcia-Garcia I, Zalba S, Campuzano Saavedra V, Garcia-Gala J, Vidan J, Moreno G, Lopez Lorenzo J, Gonzalez Arias E, Freiria C, Sole M, Avila Idrovo L, Hernandez Castellet J, Cruz N, Lavilla E, Perez-Montana A, Atucha J, Moreno Beltran M, Romero Macias J, Salinas Argente R, Del Rio-Garma J. Blood Advances. 2022 Dec 27;6(24):6219-6227. doi: 10.1182/bloodadvances.2022008028. PMID: 35930694

Recommendations for the diagnosis and treatment of patients with thrombotic thrombocytopenic purpura. Mingot Castellano M, Pascual Izquierdo C, Gonzalez A, Viejo Llorente A, Valcarcel Ferreiras D, Sebastian E, Garcia Candel F, Sarmiento Palao H, Gomez Segui I, de la Rubia J, Cid J, Martinez Nieto J, Hernandez Mateo L, Goterris Viciedo R, Fidalgo T, Salinas R, Del Rio-Garma J, Grupo Espanol de Aferesis (GEA). Medicina Clinica. 2022 Jun 24;158(12):630.e1-630.e14. doi: 10.1016/j.medcli.2021.03.040. PMID: 34266669

Safety and feasibility of stem cell boost as a salvage therapy for severe hematotoxicity after CD19 CAR T-cell therapy. Rejeski K, Burchert A, Iacoboni G, Sesques P, Fransecky L, Bucklein V, Trenker C, Hernani R, Naumann R, Schafer J, Blumenberg V, Schmidt C, Sohlbach K, von Bergwelt-Baildon M, Bachy E, Barba P, Subklewe M. Blood Advances. 2022 Aug 23;6(16):4719-4725. doi: 10.1182/bloodadvances.2022007776. PMID: 35793454

SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders. Pinana JL, Lopez-Corral L, Martino R, Vazquez L, Perez A, Martin-Martin G, Gago B, Sanz-Linares G, Sanchez-Salinas A, Villalon L, Conesa-Garcia V, Olave MT, Corona M, Marcos-Corrales S, Tormo M, Hernandez-Rivas JA, Montoro J, Rodriguez-Fernandez A, Risco-Galvez I, Rodriguez-Belenguer P, Hernandez-Boluda JC, Garcia-Cadenas I, Ruiz-Garcia M, Munoz-Bellido JL, Solano C, Cedillo A, Sureda A, Navarro D. Journal of Hematology & Oncology. 2022 May 7;15(1):54. doi: 10.1186/s13045-022-01275-7. PMID: 35526045

SARS-CoV-2-reactive antibody detection after SARS-CoV-2 vaccination in hematopoietic stem cell transplant recipients: Prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC). Pinana J, Lopez-Corral L, Martino R, Montoro J, Vazquez L, Perez A, Martin-Martin G, Facal-Malvar A, Ferrer E, Pascual M, Sanz-Linares G, Gago B, Sanchez-Salinas A, Villalon L, Conesa-Garcia V, Olave M, Lopez-Jimenez J, Marcos-Corrales S, Garcia-Blazquez M, Garcia-Gutierrez V, Hernandez-Rivas J, Saus A, Espigado I, Alonso C, Hernani R, Solano C, Ferrer-Lores B, Guerreiro M, Ruiz-Garcia M, Munoz-Bellido J, Navarro D, Cedillo A, Sureda A, Infectious Complications Subcommittee of the Spanish Hematopoietic Stem, Cell Transplantation and Cell Therapy Group (GETH-TC). American Journal of Hematology. 2022 Jan 1;97(1):30-42. doi: 10.1002/ajh.26385. PMID: 34695229

SARS-CoV-2-reactive IFN-gamma-producing CD4+ and CD8+ T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients. Olea B, Albert E, Gimenez E, Torres I, Amat P, Remigia M, Alberola J, Carbonell N, Ferreres J, Blasco M, Navarro D. Scientific Reports. 2022 Aug 22;12(1):14271. doi: 10.1038/s41598-022-18659-x. PMID: 35995830

Spanish Society of Hematology and Hemotherapy expert consensus opinion for SARS-CoV-2 vaccination in onco-hematological patients. Pinana J, Vazquez L, Martino R, de la Camara R, Sureda A, Rodriguez-Veiga R, Garrido A, Sierra J, Ribera J, Torrent A, Mateos M, de la Rubia J, Tormo M, Diez-Campelo M, Garcia-Gutierrez V, Alvarez-Larran A, Sancho J, MartinGarcia-Sancho A, Yanez L, Simon J, Barba P, Abrisqueta P, Alvarez-Twose I, Bonanad S, Lecumberri R, Ruiz-Camps I, Navarro D, Hernandez-Rivas J, Cedillo A, Garcia-Sanz R, Bosch F. Leukemia & Lymphoma. 2022 Mar;63(3):538-550. doi: 10.1080/10428194.2021.1992619. PMID: 34668835

Toxicities following CAR-T therapy for hematological malignancies. Hernani R, Benzaquen A, Solano C. Cancer Treatment Reviews. 2022 Dec;111:102479. doi: 10.1016/j.ctrv.2022.102479. PMID: 36308910

A phase I/II dose-escalation multi-center study to evaluate the safety of infusion of natural killer cells or memory T cells as adoptive therapy in coronavirus pneumonia and/or lymphopenia: RELEASE study protocol. García-García I, Guerra-García P, Ferreras C, Borobia A, Carcas A, Queiruga-Parada J, Vicario J, Mirones I, Solano Vercet C, Eguizabal C, Soria B, Pérez-Martínez A. Trials. 2021 Oct 2;22(1):674. doi: 10.1186/s13063-021-05625-7. PMID: 34600562

Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients. Olea B, Albert E, Torres I, Amat P, Remigia M, Gozalbo-Rovira R, Rodriguez-Diaz J, Buesa J, Blasco M, Redon J, Signes-Costa J, Navarro D. Journal of Clinical Virology. 2021 Sep;142:104943. doi: 10.1016/j.jcv.2021.104943. PMID: 34391981

Addition of rituximab in reduced intensity conditioning regimens for B-Cell malignancies does not influence transplant outcomes: EBMT registry analyses following allogeneic stem cell transplantation for B-Cell malignancies. Tomaszewska A, Jagasia M, Beohou E, van der Werf S, Blaise D, Kanfer E, Milpied N, Remenyi P, Ciceri F, Bourhis J, Chevallier P, Solano C, Socie G, Bruno B, Rambaldi A, Castagna L, Kroger N, Corradini P, Afanasyev B, Ladetto M, Niederwieser D, Scheid C, Sengeloev H, Kroschinsky F, Yakoub-Agha I, Schoemans H, Koenecke C, Penack O, Peric Z, Greinix H, Duarte R, Basak G. Frontiers in Immunology. 2021 Feb 2;11:613954. doi: 10.3389/fimmu.2020.613954. PMID: 33603743

Allogeneic Hematopoietic Stem Cell Transplant recipients in Spain: Human Leucocyte Antigen characteristics and diversity by high-resolution analysis. Guerreiro M, Planelles D, Aguilar-Gallardo C, Lorenzo J, Montoro J, Sanz J, Balaguer A, Gomez I, Solves P, Perez A, Blanquer M, Espigado I, Solano C, Pinana J, Grupo Espanol de Trasplante Hematopoyetico y Terapia Celular (GETH). HLA. 2021 Mar;97(3):198-213. doi: 10.1111/tan.14179. PMID: 33369244

Allogeneic stem cell transplantation as a curative option in relapse/refractory diffuse large B cell lymphoma: Spanish multicenter GETH/GELTAMO study. Bento L, Gutierrez A, Novelli S, Montoro J, Pinana J, Lopez-Corral L, Cabrero M, Martin-Sancho A, Gutierrez-Garcia G, Ortiz-Moscovich M, Bastos-Oreiro M, Dorado N, Perez A, Hernani R, Ferra C, Parody R, Garcia-Cadenas I, Herrera P, Rodriguez G, Rodriguez N, Martin C, Yanez L, Zanabili J, Varela M, Lopez-Godino O, Heras I, Espanol I, Martinez C, Perez-Simon J, Solano C, Sureda A, Sierra J, Sampol A, Caballero D, GETH, Grp Espanol Li. Bone Marrow Transplantation. 2021 Aug;56(8):1919-1928. doi: 10.1038/s41409-021-01264-3. PMID: 33767400

Amplification of human beta-glucoronidase gene for appraising the accuracy of negative SARS-CoV-2 RT-PCR results in upper respiratory tract specimens. Albert Vicent E, Ferrer Lores B, Torres Fink I, Serrano Alcalá A, Alcaráz Soriana M, Buesa Gomez J, Solano Vercet C, Colomina Rodríguez F, Bueno Ferrando F, Huntley Pascual D, Olea Miguel B, Valdivia Piqueres A, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):48-50. doi: 10.1002/jmv.26112. PMID: 32484950

An investigation of the potential association between gastrointestinal viral and bacterial infection and development of intestinal acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. Bueno F, Albert E, Gimenez E, Pinana J, Perez A, Gomez M, Hernandez-Boluda J, Gonzalez-Barbera E, Montoro J, Buesa J, Guerreiro M, Balaguer-Rosello A, Hernani R, Sanz J, Solano C, Navarro D. Journal of Medical Virology. 2021 Aug;93(8):4773-4779. doi: 10.1002/jmv.26892. PMID: 33605457

Assessing the potential association between SARS-CoV-2 RNA load in the respiratory tract and COVID-19 mortality. Albert E, Bracho M, Serrano A, Ferrer B, Gonzalez-Candelas F, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):1862-1864. doi: 10.1002/jmv.26644. PMID: 33135804

B and T cell immune responses elicited by the Comirnaty COVID-19 vaccine in nursing home residents. Torres I, Albert E, Gimenez E, Alcaraz MJ, Botija P, Amat P, Remigia MJ, Beltran MJ, Rodado C, Huntley D, Olea B, Navarro D. Clinical Microbiology and Infection. 2021 Nov;27(11):1672-1677. doi: 10.1016/j.cmi.2021.06.013. PMID: 34174397

Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure. Mollar A, Marrachelli V, Nunez E, Monleon D, Bodi V, Sanchis J, Navarro D, Nunez J. Scientific reports. 2021 Mar 17;11(1):6110. doi: 10.1038/s41598-021-85527-5. PMID: 33731747

Biomarker profile predicts clinical efficacy of extracorporeal photopheresis in steroid-resistant acute and chronic graft-vs-host disease after allogenic hematopoietic stem cell transplant. Amat P, Lopez-Corral L, Goterris R, Perez A, Lopez O, Heras I, Arbona C, Viguria MC, Hernandez-Boluda JC, Martinez-Ruiz F, Martinez A, Solano C. Journal of Clinical Apheresis. 2021 Oct;36(5):697-710. doi: 10.1002/jca.21918. PMID: 34185332

CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review. Hernani R, Sancho A, Amat P, Hernandez-Boluda J, Perez A, Pinana J, Carretero C, Goterris R, Gomez M, Saus A, Ferrer B, Teruel A, Terol M, Solano C. Current Research in Translational Medicine. 2021 Jul 22;69(4):103304. doi: 10.1016/j.retram.2021.103304. PMID: 34303899

Caveats in interpreting SARS-CoV-2 IgM positive/IgG negative antibody profile in asymptomatic health care workers.. Valdivia Piqueres A, Torres Fink I, Huntley Pascual D, Alcaráz Soriana M, Albert Vicent E, Solano De La Asunción C, González Padrón C, Ferrer Dot J, Navarro Ortega D. Journal of Medical Virology. 2021 Feb;93(2):634-636. doi: 10.1002/jmv.26400. PMID: 32761912

Clinical outcomes of allogeneic hematopoietic stem cell transplant recipients developing Cytomegalovirus DNAemia prior to engraftment. Solano C, Vazquez L, Gimenez E, de la Camara R, Albert E, Rovira M, Espigado I, Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Pinana J, Navarro D, Spanish Group of Hematopoietic Transplantation and Cell Therapy (GETH). Bone Marrow Transplantation. 2021 Jun;56(6):1281-1290. doi: 10.1038/s41409-020-01157-x. PMID: 33319853

Common seasonal respiratory virus infections in allogeneic stem cell transplant recipients during the SARS-COV-2 pandemic. De la Puerta R, Montoro J, Aznar C, Lorenzo I, González-Barberá EM, Balaguer-Roselló A, Guerreiro M, Domínguez L, Salavert M, Aguilar C, de la Rubia J, Sanz J, Gómez MD, Piñana JL. Bone Marrow Transplantation. 2021 Sep;56(9):2212-2220. doi: 10.1038/s41409-021-01319-5. PMID: 33947980

COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey. Ljungman P, de la Camara R, Mikulska M, Tridello G, Aguado B, Al Zahrani M, Apperley J, Berceanu A, Bofarull RM, Calbacho M, Ciceri F, Lopez-Corral L, Crippa C, Fox ML, Grassi A, Jimenez MJ, Demir SK, Kwon M, Llamas C, Lorenzo JL, Mielke S, Orchard K,Porras RP, Vallisa D, Xhaard A, Knelange NS, Cedillo A, Kroger N, Pinana JL, Styczynski J. Leukemia. 2021 Oct;35(10):2885-2894. doi: 10.1038/s41375-021-01302-5. PMID: 34079042

COVID-19 infodemics: the role of mainstream and social media. Focosi D, Navarro D, Maggi F, Roilides E, Antonelli G. Clinical microbiology and infection. 2021 Nov;27(11):1568-1569. doi: 10.1016/j.cmi.2021.08.003. PMID: 34375756

Cytomegalovirus DNAemia and risk of mortality in allogeneic hematopoietic stem cell transplantation: Analysis from the Spanish Hematopoietic Transplantation and Cell Therapy Group. Solano Vercet C, Vazquez L, Gimenez Quiles E, De La Camara R, Albert Vicent E, Rovira M, Espigado I, Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez Martinez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Bautista G, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Pinana J, Navarro Ortega D. American Journal of Transplantation. 2021 Jan;21(1):258-271. doi: 10.1111/ajt.16147. PMID: 32812351

Cytomegalovirus-specific T-cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib. De la Asuncion C, Terol M, Saus A, Olea B, Gimenez E, Albert E, Lopez-Jimenez J, Andreu R, Garcia D, Fox L, Remigia M, Amat P, Solano C, Navarro D. British Journal of Haematology. 2021 Nov;195(4):637-641. doi: 10.1111/bjh.17732. PMID: 34402042

Diagnostic significance of SARS-CoV-2 IgM positive/IgG negative antibody profile in symptomatic patients with suspected COVID-19 testing negative by RT-PCR. Valdivia Piqueres A, Torres Fink I, Huntley Pascual D, Alcaráz Soriana M, Albert Vicent E, González Padrón C, Colomina Rodríguez F, Navarro Ortega D. The Journal of infection. 2021 Jan;82(1):e15-e16. doi: 10.1016/j.jinf.2020.08.028. PMID: 32853600

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2021 Aug;93(8):5167-5172. doi: 10.1002/jmv.26661. PMID: 33174620

Early detection of SARS-CoV-2 infection cases or outbreaks at nursing homes by targeted wastewater tracking. Davo L, Segui R, Botija P, Beltran M, Albert E, Torres I, Lopez-Fernandez P, Orti R, Maestre J, Sanchez G, Navarro D. Clinical Microbiology and Infection. 2021 Jul;27(7):1061-1063. doi: 10.1016/j.cmi.2021.02.003. PMID: 33601008

Evaluation of a rapid antigen detection test (Panbio (TM) COVID-19 Ag Rapid Test Device) as a point-of-care diagnostic tool for COVID-19 in a pediatric emergency department. Carbonell-Sahuquillo S, Lazaro-Carreno M, Camacho J, Barres-Fernandez A, Albert E, Torres I, Breton-Martinez J, Martinez-Costa C, Navarro D. Journal of Medical Virology. 2021 Dec;93(12):6803-6807. doi: 10.1002/jmv.27220. PMID: 34289136

Evaluation of a rapid antigen test (Panbio COVID-19 Ag rapid test device) for SARS-CoV-2 detection in asymptomatic close contacts of COVID-19 patients. Torres I, Poujois S, Albert E, Colomina J, Navarro D. Clinical microbiology and infection. 2021 Apr;27(4):636.e1-636.e4. doi: 10.1016/j.cmi.2020.12.022. PMID: 33421573

Evolutionary and phenotypic characterization of two spike mutations in european lineage 20E of SARS-CoV-2. Ruiz-Rodriguez P, Frances-Gomez C, Chiner-Oms A, Lopez MG, Jimenez-Serrano S, Cancino-Munoz I, Ruiz-Hueso P, Torres-Puente M, Bracho MA, D’Auria G, Martinez-Priego L, Guerreiro M, Montero-Alonso M, Gomez MD, Pinana JL, Gonzalez-Candelas F, Comas I, Marina A, Geller R, Coscolla M. mBio. 2021 Nov 16;12(6):e0231521. doi: 10.1128/mBio.02315-21. PMID: 34781748

Evolving patterns of care and outcomes in relapsed/refractory FLT3 mutated acute myeloid leukemia adult patients. Boluda B, Martinez-Cuadron D, Algarra L, Cano I, Sayas M, Acuna-Cruz E, Blanco A, Marco-Ayala J, DeLapuerta R, Diaz-Gonzalez A, Tormo M, Rodriguez-Veiga R, Garcia R, Pinana J, Lopez-Pavia M, Barragan E, Amigo M, Sargas C, Lopez A, Solana-Altabella A, Gil C, Megias-Vericat J, Sanz M, Montesinos P. Leukemia & Lymphoma. 2021 Nov;62(11):2727-2736. doi: 10.1080/10428194.2021.1938031. PMID: 34121593

Ex vivo T-cell depletion vs post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil as graft-vs-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Montoro J, Roldan E, Pinana J, Barba P, Chorao P, Quintero A, Hernani R, Orti G, Lorenzo J, Balaguer-Rosello A, Salamero O, Fox L, Solves P, Gomez I, Guerreiro M, Boluda J, Sanz G, Solano C, Sanz M, Valcarcel D, Sanz J. European Journal of Haematology. 2021 Jan;106(1):114-125. doi: 10.1111/ejh.13529. PMID: 33025625

Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centers. Albert Vicent E, Torres Fink I, Bueno Ferrando F, Huntley Pascual D, Molla E, Fernandez-Fuentes M, Martínez López M, Poujois Gisbert S, Forqué Rodríguez L, Valdivia Piqueres A, Solano De La Asunción C, Ferrer Dot J, Colomina Rodríguez F, Navarro Ortega D. Clinical microbiology and infection. 2021 Mar;27(3):472.e7-472.e10. doi: 10.1016/j.cmi.2020.11.004. PMID: 33189872

Fundamentals and implementation of Microbiological Diagnostic Stewardship Programs. Bou G, Canton R, Martinez-Martinez L, Navarro Ortega D, Vila J. Enfermedades Infecciosas y Microbiologia Clinica. 2021 May;39(5):248-251. doi: 10.1016/j.eimc.2020.02.019. PMID: 32234252

Hospital and outpatient models for Hematopoietic Stem Cell Transplantation: a systematic review of comparative studies for health outcomes, experience of care and costs. Gonzalez M, Urizar E, Urtaran-Laresgoiti M, Nuno-Solinis R, Lazaro-Perez E, Vazquez L, Pascual-Cascon M, Solano C, Kwon M, Gallego C, Fernandez-Aviles F. PLoS One. 2021 Aug 12;16(8):e0254135. doi: 10.1371/journal.pone.0254135. PMID: 34383780

Impact of BCR-ABL1 transcript type on response, treatment-free remission rate and survival in chronic myeloid leukemia patients treated with imatinib. Marce S, Xicoy B, Garcia O, Cabezon M, Estrada N, Velez P, Boque C, Sagues M, Angona A, Teruel-Montoya R, Ferrer-Marin F, Amat P, Hernandez-Boluda J, Ibarra M, Anguita E, Cortes M, Fernandez-Ruiz A, Fontanals S, Zamora L, Grp Espanol Leucemia Mieloide Cron. Journal of Clinical Medicine. 2021 Jul 16;10(14):3146. doi: 10.3390/jcm10143146. PMID: 34300312

Inference of SARS-CoV-2 spike-binding neutralizing antibody titers in sera from hospitalized COVID-19 patients by using commercial enzyme and chemiluminescent immunoassays. Valdivia A, Torres I, Latorre V, Frances-Gomez C, Albert E, Gozalbo-Rovira R, Alcaraz M, Buesa J, Rodriguez-Diaz J, Geller R, Navarro D. European Journal of Clinical Microbiology & Infectious Diseases. 2021 Mar;40(3):485-494. doi: 10.1007/s10096-020-04128-8. PMID: 33404891

Initial viral load and decay kinetics of SARS-CoV-2 lineage B.1.1.7 in the upper respiratory tract of adults and children. Costa R, Bueno F, Gimenez E, Bracho A, Albert E, Carretero D, de Michelena P, Martinez-Costa C, Gonzalez-Candelas F, Navarro D. Journal of Infection. 2021 Oct;83(4):496-522. doi: 10.1016/j.jinf.2021.08.015. PMID: 34390756

Lower respiratory tract and plasma SARS-CoV-2 RNA load in critically ill adult COVID-19 patients: Relationship with biomarkers of disease severity. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Infection. 2021 Sep;83(3):381-412. doi: 10.1016/j.jinf.2021.05.036. PMID: 34087349

Maturity Assessment model for Patient Blood Management to assist hospitals in improving patients’ safety and outcomes. The MAPBM project. Bisbe E, Garcia-Casanovas A, Illa C, et al, MAPBM Working Group. Blood transfusión. 2021 May;19(3):205-215. doi: 10.2450/2020.0105-20. PMID: 32955422

Myelodysplastic syndromes with 20q deletion: incidence, prognostic value and impact on response to azacitidine of ASXL1 chromosomal deletion and genetic mutations. Martin I, Villamon E, Abellan R, Calasanz M, Irigoyen A, Sanz G, Such E, Mora E, Gutierrez M, Collado R, Garcia-Serra R, Vara M, Blanco M, Oiartzabal I, Alvarez S, Bernal T, Granada I, Xicoy B, Jerez A, Calabuig M, Diez R, Gil A, Diez-Campelo M, Solano C, Tormo M, Spanish Grp Myelodysplastic Syn. British Journal of Haematology. 2021 Aug;194(4):708-717. doi: 10.1111/bjh.17675. PMID: 34296432

Performance of a MALDI-TOF mass spectrometry-based method for rapid detection of third-generation oxymino-cephalosporin-resistant Escherichia coli and Klebsiella spp. from blood cultures. Torres I, Albert E, Gimenez E, Olea B, Valdivia A, Pascual T, Huntley D, Sanchez D, Costa RM, Pinto C, Oltra R, Colomina J, Navarro D. European Journal of Clinical Microbiology & Infectious Diseases. 2021 Sep;40(9):1925-1932. doi: 10.1007/s10096-021-04251-0. PMID: 33876385

Platinum chloride-based viability RT-qPCR for SARS-CoV-2 detection in complex samples. Cuevas-Ferrando E, Randazzo W, Perez-Cataluna A, Falco I, Navarro D, Martin-Latil S, Diaz-Reolid A, Giron-Guzman I, Allende A, Sanchez G. Scientific Reports. 2021 Sep 13;11(1):18120. doi: 10.1038/s41598-021-97700-x. PMID: 34518622

Post-transplant cyclophosphamide for GVHD prophylaxis compared to ATG-based prophylaxis in unrelated donor transplantation. Bailen R, Kwon M, Pascual-Cascon M, Ferra C, Sanz J, Gallardo-Morillo A, Garcia-Sola A, Torrent A, Jimenez-Lorenzo M, Pinana J, Montoro J, Oarbeascoa G, Dorado N, Gomez-Centurion I, Munoz C, Martinez-Laperche C, Anguita J, Buno I, Diez-Martin J, Grp Espanol Trasplante Hematopoyet. Annals of Hematology. 2021 Feb;100(2):541-553. doi: 10.1007/s00277-020-04317-7. PMID: 33140137

Qualitative assessment of SARS-CoV-2-specific antibody avidity by lateral flow immunochromatographic IgG/IgM antibody assay. Valdivia A, Torres I, Huntley D, Alcaraz M, Albert E, Colomina J, Ferrer J, Carratala A, Navarro D. Journal of Medical Virology. 2021 Feb;93(2):1141-1144. doi: 10.1002/jmv.26344. PMID: 32706420

Real-life evaluation of a rapid extraction-free SARS-CoV-2 RT-PCR assay (COVID-19 PCR Fast-L) for the diagnosis of COVID-19. Torres I, Qualai J, Albert E, Bueno F, Huntley D, Poujois S, Gil MT, Navarro D. Journal of Medical Virology. 2021 Sep;93(9):5233-5235. doi: 10.1002/jmv.27039. PMID: 33913561

Real-world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B-cell lymphoma. Cancer medicine. Iacoboni G, Villacampa G, Martinez-Cibrian N, Bailen R, Lopez Corral L, Sanchez J, Guerreiro M, Caballero A, Mussetti A, Sancho J, Hernani Morales R, Abrisqueta P, Solano Vercet C, Sureda A, Briones J, Martin Garcia-Sancho A, Kwon M, Reguera-Ortega J, Barba P, GETH G. 2021 May;10(10):3214-3223. doi: 10.1002/cam4.3881. PMID: 33932100

Recommendations for screening, monitoring, prevention, and prophylaxis of infections in adult and pediatric patients receiving CAR T-cell therapy: a position paper. Los-Arcos I, Iacoboni G, Aguilar-Guisado M, Alsina-Manrique L, de Heredia C, Fortuny-Guasch C, Garcia-Cadenas I, Garcia-Vidal C, Gonzalez-Vicent M, Hernani R, Kwon M, Machado M, Martinez-Gomez X, Maldonado V, Pla C, Pinana J, Pomar V, Reguera-Ortega J, Salavert M, Soler-Palacin P, Vazquez-Lopez L, Barba P, Ruiz-Camps I. Infection. 2021 Apr;49(2):215-231. doi: 10.1007/s15010-020-01521-5. PMID: 32979154

SARS-CoV-2-reactive interferon-gamma-producing CD8+ T cells in patients hospitalized with Coronavirus Disease 2019. Gimenez Quiles E, Albert Vicent E, Torres Fink I, Remigia Pellicer M, Alcaráz Soriana M, Galindo Puerto M, Blasco Cortes M, Solano Vercet C, Forner Giner M, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):375-382. doi: 10.1002/jmv.26213. PMID: 32579268

SARS-CoV-2-specific cell-mediated immunity in kidney transplant recipients recovered from COVID-19. Fernandez-Ruiz M, Olea B, Gimenez E, Laguna-Goya R, Trujillo H, Caravaca-Fontan F, Gutierrez E, Lopez-Medrano F, Remigia M, Almendro-Vazquez P, Polanco N, Gonzalez E, Ruiz-Merlo T, Parra P, San Juan R, Andres A, Navarro D, Aguado J. Transplantation. 2021 Jun 1;105(6):1372-1380. doi: 10.1097/TP.0000000000003672. PMID: 33729741

SARS-CoV-2-specific memory t lymphocytes from COVID-19 convalescent donors: identification, biobanking, and large-scale production for adoptive cell therapy. Ferreras C, Pascual-Miguel B, Mestre-Duran C, Navarro-Zapata A, Clares-Villa L, Martin-Cortazar C, De Paz R, Marcos A, Vicario J, Balas A, Garcia-Sanchez F, Eguizabal C, Solano C, Mora-Rillo M, Soria B, Perez-Martinez A. Frontiers in Cell and Developmental Biology. 2021 Feb 25;9:620730. doi: 10.3389/fcell.2021.620730. PMID: 33718360

Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. Pinana J, Xhaard A, Tridello G, Passweg J, Kozijn A, Polverelli N, Heras I, Perez A, Sanz J, Berghuis D, Vazquez L, Suarez-Lledo M, Itala-Remes M, Ozcelik T, Iturrate Basaran I, Karakukcu M, Al Zahrani M, Choi G, Cuesta Casas M, Batlle Massana M, Viviana A, Blijlevens N, Ganser A, Kuskonmaz B, Labussiere-Wallet H, Shaw P, Arzu Yegin Z, Gonzalez-Vicent M, Rocha V, Ferster A, Knelange N, Navarro D, Mikulska M, de la Camara R, Styczynski J, Infectious Diseases Working Party of the European Society for Blood and, Marrow Transplantation and Infectious Complications Subcommittee of the, Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group, (GETH). The Journal of Infectious Diseases. 2021 May 20;223(9):1564-1575. doi: 10.1093/infdis/jiaa553. PMID: 32860509

Severe infections and infection-related mortality in a large series of haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide. Esquirol A, Pascual M, Kwon M, Perez A, Parody R, Ferra C, Cadenas I, Herruzo B, Dorado N, Hernani R, Sanchez-Ortega I, Torrent A, Sierra J, Martino R, Spanish Grp Hematopoietic Stem. Bone Marrow Transplantation. 2021 Oct;56(10):2432-2444. doi: 10.1038/s41409-021-01328-4. PMID: 34059802

Suitability of Two Rapid Lateral Flow Immunochromatographic Assays for Predicting SARS-CoV-2 Neutralizing Activity of Sera. Valdivia A, Torres I, Latorre V, Frances-Gomez C, Ferrer J, Forque L, Costa R, de la Asuncion C, Huntley D, Gozalbo-Rovira R, Buesa J, Gimenez E, Rodriguez-Diaz J, Geller R, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):2301-2306. doi: 10.1002/jmv.26697. PMID: 33236799

T cell-mediated response to SARS-CoV-2 in liver transplant recipients with prior COVID-19. Fernandez-Ruiz M, Olea B, Almendro-Vazquez P, Gimenez E, Marcacuzco A, San Juan R, Justo I, Calvo-Pulido J, Garcia-Sesma A, Manrique A, Caso O, Cambra F, Talayero P, Lopez-Medrano F, Remigia MJ, Ruiz-Merlo T, Parra P, Paz-Artal E, Jimenez C, Loinaz C, Navarro D, Laguna-Goya R, Aguado JM. American Journal of Transplantation. 2021 Aug;21(8):2785-2794. doi: 10.1111/ajt.16708. PMID: 34092033

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant. Lopez M, Chiner-Oms A, Garcia de Viedma D, Ruiz-Rodriguez P, Bracho M, Cancino-Munoz I, D’Auria G, de Marco G, Garcia-Gonzalez N, Goig G, Gomez-Navarro I, Jimenez-Serrano S, Martinez-Priego L, Ruiz-Hueso P, Ruiz-Roldan L, Torres-Puente M, Alberola J, Albert Vicent E, Aranzamendi Zaldumbide M, Bea-Escudero M, Boga J, Bordoy A, Canut-Blasco A, Carvajal A, Cilla Eguiluz G, Cordon Rodriguez M, Costa-Alcalde J, de Toro M, de Toro Peinado I, Del Pozo J, Duchene S, Fernandez-Pinero J, Fuster Escriva B, Gimeno Cardona C, Gonzalez Galan V, Gonzalo Jimenez N, Hernaez Crespo S, Herranz M, Lepe J, Lopez-Causape C, Lopez-Hontangas J, Martin V, Martro E, Milagro Beamonte A, Montes Ros M, Moreno-Munoz R, Navarro Ortega D, Navarro-Mari J, Not A, Oliver A, Palop-Borras B, Parra Grande M, Pedrosa-Corral I, Perez Gonzalez M, Perez-Lago L, Perez-Ruiz M, Pineiro Vazquez L, Rabella N, Rezusta A, Robles Fonseca L, Rodriguez-Villodres A, Sanbonmatsu-Gamez S, Sicilia J, Soriano A, Tirado Balaguer M, Torres Fink I, Tristancho A, Marimon J, Coscolla M, Gonzalez-Candelas F, Comas I, SeqCOVID-Spain consortium. Nature Genetics. 2021 Oct;53(10):1405-1414. doi: 10.1038/s41588-021-00936-6. PMID: 34594042

Upper respiratory tract SARS-CoV-2 RNA loads in symptomatic and asymptomatic children and adults. Costa R, Bueno F, Albert E, Torres I, Carbonell-Sahuquillo S, Barres-Fernandez A, Sanchez D, Padron C, Colomina J, Lazaro Carreno M, Breton-Martinez J, Martinez-Costa C, Navarro D. Clinical Microbiology and Infection. 2021 Dec;27(12):1858.e1-1858.e7. doi: 10.1016/j.cmi.2021.08.001. PMID: 34384874

Use of letermovir in off-label indications: Infectious Diseases Working Party of European Society of Blood and Marrow Transplantation retrospective study. Styczynski J, Tridello G, Xhaard A, Medinger M, Mielke S, Taskinen M, Blijlevens N, Rodriguez M, Solano C, Nikolousis E, Biffi A, Groll A, Junghanss C, Tsirigotis P, Lioure B, Sramek J, Holler E, Galaverna F, Fagioli F, Knelange N, Wendel L, Gil L, de la Camara R, Mikulska M, Ljungman P. Bone Marrow Transplantation. 2021 May;56(5):1171-1179. doi: 10.1038/s41409-020-01166-w. PMID: 33288863

A new clinical and immuno-virological score for predicting the risk of late severe infection in solid organ transplant recipients: the CLIV Score. San-Juan R, Fernandez-Ruiz M, Ruiz-Ruigomez M, Lopez-Medrano F, Ruiz-Merlo T, Andres A, Loinaz C, Len O, Azancot M, Montejo M, Rodriguez-Alvarez R, Fortun J, Escudero-Sanchez R, Gimenez Quiles E, Lora D, Albert Vicent E, Navarro Ortega D, Aguado J, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016). The Journal of Infectious Diseases. 2020 Jul 6;222(3):479-487. doi: 10.1093/infdis/jiaa090. PMID: 32112085

Agreements and uncertainties in autologous haematopoietic stem cell mobilization and collection. A Spanish consensus document. Bueno J, Alegre A, Lopez-Villar O, Querol S, Arroyo J, Goterris Viciedo R, Sureda A, Garcia-Gala J, Amunarriz C, Albo C, Fernandez-Fuertes F, Medina L, Antelo M, Blanquer M, Vallejo C, Canales M, Vidales-Mancha I, Duarte R. Bone Marrow Transplantation. 2020 Apr;55(4):811-817. doi: 10.1038/s41409-019-0716-9. PMID: 31690809

Algorithm to Study HLA-Antibodies and Selecting Criteria for the Best Haploidentical Donor. Luis-Hidalgo M, Silvestre D, Guzm?n-Fulgencio M, Castro E, Solano C. Indian Journal of Hematology and Blood Transfusion. 2020 Jul;36(3):573-574. doi: 10.1007/s12288-019-01246-y. PMID: 32647437

An investigation of the utility of plasma Cytomegalovirus (CMV) microRNA detection to predict CMV DNAemia in allogeneic hematopoietic stem cell transplant recipients. Talaya Peñalver A, Gimenez Quiles E, Pascual M, Gago B, Piñana Sanchez J, Hernandez Boluda J, Vazquez L, Garcia M, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Medical Microbiology And Immunology. 2020 Feb;209(1):15-21. doi: 10.1007/s00430-019-00632-7. PMID: 31478067

Assessing the impact on intestinal microbiome and clinical outcomes of antibiotherapy optimisation strategies in haematopoietic stem cell transplant recipients: study protocol for the prospective multicentre OptimBioma study. Jimenez-Jorge S, Labrador-Herrera G, Rosso-Fernandez C, Rodriguez-Torres N, Pachon-Ibanez M, Smani Y, Marquez-Malaver F, Limon Ramos C, Solano Vercet C, Vazquez-Lopez L, Kwon M, Mora Barrios J, Aguilar-Guisado M, Espigado I, GETH (Grupo Espanol de Trasplante Hematopoyetico y Terapia Celular). BMJ Open. 2020 Jul 20;10(7):e034570. doi: 10.1136/bmjopen-2019-034570. PMID: 32690735

Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell transplantation. Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Hernandez Boluda J, Gimenez Quiles E, Gomez M, Balaguer-Rosello A, Gonzalez-Barbera E, Guerreiro M, Aguilar C, Navarro Ortega D, Solano Vercet C, Sanz J, Luis Pinana J. Transplant Infectious Disease. 2020 Aug;22(4):e13301. doi: 10.1111/tid.13301. PMID: 32363665

Assessment of prevalence and load of torquetenovirus viraemia in a large cohort of healthy blood donors. Focosi D, Spezia P, Macera L, Salvadori S, Navarro Ortega D, Lanza M, Antonelli G, Pistello M, Maggi F. Clinical Microbiology and Infection. 2020 Oct;26(10):1406-1410. doi: 10.1016/j.cmi.2020.01.011. PMID: 31972321

Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) (vol 55, pg 681, 2019). Snowden J, Saccardi R, Orchard K, Ljungman P, Duarte R, Labopin M, McGrath E, Brook N, de Elvira C, Gordon D, Poirel H, Ayuk F, Beguin Y, Bonifazi F, Gratwohl A, Milpied N, Moore J, Passweg J, Rizzo J, Spellman S, Sierra J, Solano Vercet C, Sanchez-Guijo F, Worel N, Gusi A, Adams G, Balan T, Baldomero H, Macq G, Marry E, Mesnil F, Oldani E, Pearce R, Perry J, Raus N, Schanz U, Tran S, Wilcox L, Basak G, Chabannon C, Corbacioglu S, Dolstra H, Kuball J, Mohty M, Lankester A, Montoto S, Nagler A, Styczynski J, Yakoub-Agha I, de Latour R, Kroeger N, Brand R, de Wreede L, van Zwet E, Putter H. Bone Marrow Transplantation. 2020 Apr;55(4):838-839. doi: 10.1038/s41409-019-0740-9. PMID: 31754251

Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Snowden J, Saccardi R, Orchard K, Ljungman P, Duarte R, Labopin M, McGrath E, Brook N, de Elvira C, Gordon D, Poirel H, Ayuk F, Beguin Y, Bonifazi F, Gratwohl A, Milpied N, Moore J, Passweg J, Rizzo J, Spellman S, Sierra J, Solano Vercet C, Sanchez-Guijo F, Worel N, Gusi A, Adams G, Balan T, Baldomero H, Macq G, Marry E, Mesnil F, Oldani E, Pearce R, Perry J, Raus N, Schanz U, Tran S, Wilcox L, Basak G, Chabannon C, Corbacioglu S, Dolstra H, Kuball J, Mohty M, Lankester A, Montoto S, Nagler A, Styczynski J, Yakoub-Agha I, de Latour R, Kroeger N, Brand R, de Wreede L, van Zwet E, Putter H. Bone Marrow Transplantation. 2020 Apr;55(4):681-694. doi: 10.1038/s41409-019-0718-7. PMID: 31636397

Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens. Luis Pinana J, Albert Vicent E, Dolores Gomez M, Perez Martinez A, Hernandez Boluda J, Montoro J, Salavert M, Maria Gonzalez E, Tormo Diaz M, Gimenez Quiles E, Villalba M, Balaguer-Rosello A, Hernani Morales R, Bueno Ferrando F, Borras Salvador R, Sanz J, Solano Vercet C, Navarro Ortega D. The Journal of infection. 2020 May;80(5):578-606. doi: 10.1016/j.jinf.2020.01.001. PMID: 31926954

Co-detection of respiratory pathogens in patients hospitalized with Coronavirus viral disease-2019 pneumonia. Blasco Cortes M, Buesa Gomez J, Colomina Rodríguez F, Forner Giner M, Galindo Puerto M, Navarro Perez J, Noceda Bermejo J, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal Of Medical Virology. 2020 Oct;92(10):1799-1801. doi: 10.1002/jmv.25922. PMID: 32320082

Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation. Montoro J, Sanz J, Lorenzo I, Balaguer-Roselló A, Salavert M, Gómez MD, Guerreiro M, González Barberá EM, Aguado C, Tofán L, Sanz GF, Sanz MA, Piñana JL. Bone Marrow Transplantation. 2020 Dec;55(12):2261-2269. doi: 10.1038/s41409-020-0943-0. PMID: 32415227

Cytomegalovirus DNA load monitoring in stool specimens for anticipating the occurrence of intestinal acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: Is it of any value?. Bueno Ferrando F, Albert Vicent E, Gimenez Quiles E, Pinana J, Perez Martinez A, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Aug 9;e13440. doi: 10.1111/tid.13440. PMID: 32772456

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Early kinetics of Torque Teno virus DNA load and BK polyomavirus viremia after kidney transplantation. Fernandez-Ruiz M, Albert Vicent E, Gimenez Quiles E, Rodriguez-Goncer I, Andres A, NAVARRO ORTEGA D, Maria Aguado J. Transplant infectious disease. 2020 Apr;22(2):e13240. doi: 10.1111/tid.13240. PMID: 31883425

Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Network for Research in Infectious Diseases (REIPI) and the Spanish Society of Haematology and Haemotherapy (SEHH) on the management of febrile neutropenia in patients with hematological malignancies. Gudiol C, Aguilar-Guisado M, Azanza J, Candel F, Cantón R, Carratalà J, Garcia-Vidal C, Jarque I, Lizasoain M, Gil-Bermejo J, Ruiz-Camps I, Sánchez-Ortega I, Solano Vercet C, Suárez-Lledó M, Vázquez L, De La Cámara R. Enfermedades Infecciosas y Microbiologia Clinica. 2020 Apr;38(4):174-181. doi: 10.1016/j.eimc.2019.01.013. PMID: 30926172

Feasibility of thiotepa addition to the fludarabine-busulfan conditioning with tacrolimus/sirolimus as graft vs host disease prophylaxis. Fox M, Garcia-Cadenas I, Perez Martinez A, Villacampa G, Pinana J, Orti G, Montoro J, Roldan E, Bosch Vilaseca A, Martino R, Salamero O, Saavedra S, Hernandez Boluda J, Esquirol A, Sierra J, Sanz J, Solano Vercet C, Bosch F, Barba P, Valcarcel D. Leukemia & Lymphoma. 2020 Aug;61(8):1823-1832. doi: 10.1080/10428194.2020.1788015. PMID: 32654570

Features of Cytomegalovirus DNAemia Blips in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Implications for Optimization of Preemptive Antiviral Therapy Strategies. Huntley Pascual D, Talaya Peñalver A, Gimenez Quiles E, Perez Martinez A, Hernandez Boluda J, Hernani Morales R, Torres Fink I, Alberola J, Albert Vicent E, Piñana Sanchez J, Solano Vercet C, Navarro Ortega D. Biology of Blood and Marrow Transplantation. 2020 May;26(5):972-977. doi: 10.1016/j.bbmt.2020.01.015. PMID: 32007638

Field Performance of the Abbott RealTime MTB Assay for the Diagnosis of Extrapulmonary Tuberculosis in a Low-Prevalence Setting. Borrás R, Martínez V, Vinuesa V, Torres I, Orta N, Clari MA, Prat J, Navarro D. Enfermedades Infecciosas Y Microbiologia Clinica. 2020 May;38(5):206-211. doi: 10.1016/j.eimc.2019.08.007. PMID: 31668859

Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium. Sanchez-Maldonado J, Campa D, Springer J, Badiola J, Niazi Y, Moniz-Diez A, Hernandez-Mohedo F, Gonzalez-Sierra P, Ter Horst R, Macauda A, Brezina S, Cunha C, Lackner M, Lopez-Nevot M, Fianchi L, Pagano L, Lopez-Fernandez E, Potenza L, Luppi M, Moratalla L, Rodriguez-Sevilla J, Fonseca J, Tormo Diaz M, Solano Vercet C, Clavero E, Romero A, Li Y, Lass-Florl C, Einsele H, Vazquez L, Loeffler J, Hemminki K, Carvalho A, Netea M, Gsur A, Dumontet C, Canzian F, Forsti A, Jurado M, Sainz J. Blood Cancer Journal. 2020 Jul 16;10(7):75. doi: 10.1038/s41408-020-00341-y. PMID: 32678078

Impact of clinical features, cytogenetics, genetic mutations, and methylation dynamics of CDKN2B and DLC-1 promoters on treatment response to azacitidine. Martin Gonzalez I, Navarro Cubells B, Serrano Alcalá A, Villamón Ribate E, Calabuig Muñoz M, Solano Vercet C, Chaves Martínez F, Yague N, Orts M, Amat Martínez P, Fuentes Trillo A, Seda García E, García García F, Hernandez Boluda J, Tormo Diaz M. Annals of Hematology. 2020 Mar;99(3):527-537. doi: 10.1007/s00277-020-03932-8. PMID: 31989250

Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with post-transplantation cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Jesus Pascual M, Hernandez Boluda J, Gago B, Vazquez Lopez L, Luis Pinana J, Garcia M, Perez Martinez A, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Feb;22(1):e13206. doi: 10.1111/tid.13206. PMID: 31677215

Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: some nuances. Aguilar Aguilar G, Ferriols Lisart R, Martínez Castro S, Ezquer Garin C, Pastor Martinez E, Carbonell Lopez J, Alos Almiñana M, Navarro Ortega D. Critical Care. 2020 Jan 10;24(1):11. doi: 10.1186/s13054-019-2724-y. PMID: 31924240

Partial T Cell-Depleted Peripheral Blood Stem Cell Transplantation from HLA-Identical Sibling Donors for Patients with Severe Aplastic Anemia. Sanz J, Moscardo F, Montoro J, Cano I, Guerreiro M, Dasi M, Solves P, Lorenzo I, Gomez-Segui I, Montesinos P, Mora E, Arnao M, Sempere A, Jarque I, Carretero C, Senent L, Vicente A, Andreu R, Luna I, Balaguer-Rosello A, Carpio N, Sanz G, Sanz M, Pinana J. Biology of Blood and Marrow Transplantation. 2020 Jan;26(1):83-87. doi: 10.1016/j.bbmt.2019.08.020. PMID: 31493538

Peripheral blood regulatory T cells and occurrence of Cytomegalovirus DNAemia after unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Vázquez L, Amat Martínez P, Remigia Pellicer M, Hernández M, Hernandez Boluda J, Gago B, Piñana Sanchez J, García M, Perez Martinez A, Alberola J, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1493-1496. doi: 10.1038/s41409-020-0950-1. PMID: 32447351

Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis. Lupianez C, Martinez-Bueno M, Sanchez-Maldonado J, Badiola J, Cunha C, Springer J, Lackner M, Segura-Catena J, Canet L, Alcazar-Fuoli L, Lopez-Nevot M, Fianchi L, Aguado J, Pagano L, Lopez-Fernandez E, Alarcon-Riquelme M, Potenza L, Goncalves S, Luppi M, Moratalla L, Solano Vercet C, Sampedro A, Gonzalez-Sierra P, Cuenca-Estrella M, Lagrou K, Maertens J, Lass-Floerl C, Einsele H, Vazquez L, Loeffler J, Rios-Tamayo R, Carvalho A, Jurado M, Sainz J. Infection and Immunity. 2020 Mar 23;88(4):e00882-19. doi: 10.1128/IAI.00882-19. PMID: 31964743

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium. Sanchez-Maldonado J, Moniz-Diez A, Ter Horst R, Campa D, Cabrera-Serrano A, Martinez-Bueno M, Garrido-Collado M, Hernandez-Mohedo F, Fernandez-Puerta L, Lopez-Nevot M, Cunha C, Gonzalez-Sierra P, Springer J, Lackner M, Alcazar-Fuoli L, Fianchi L, Aguado J, Pagano L, Lopez-Fernandez E, Clavero E, Potenza L, Luppi M, Moratalla L, Solano C, Sampedro A, Cuenca-Estrella M, Lass-Florl C, Pcraga Study Group, Canzian F, Loeffler J, Li Y, Einsele H, Netea M, Vazquez L, Carvalho A, Jurado M, Sainz J. Journal Of Fungi. 2020 Dec 23;7(1):E4. doi: 10.3390/jof7010004. PMID: 33374839

Pooling of Nasopharyngeal Swab Specimens for SARS-CoV-2 detection by RT-PCR. Torres Fink I, Albert Vicent E, Navarro Ortega D. Journal of Medical Virology. 2020 Nov;92(11):2306-2307. doi: 10.1002/jmv.25971. PMID: 32369202

Predicting Mortality after Autologous Transplant: Development of a Novel Risk Score. Berro M, Chhabra S, Pinana J, Arbelbide J, Rivas M, Basquiera A, Vitriu A, Requejo A, Milovic V, Yantorno S, Bentolila G, Garcia J, Castro M, Palmer S, Saslavsky M, Duarte P, Cerutti A, Jarchum G, Bana M, Thapa B, Solano C, Sureda A, Rovira M, Shaw B, Kusminsky G, Grp Argentino Trasplante Medula Os. Biology of Blood and Marrow Transplantation. 2020 Oct;26(10):1828-1832. doi: 10.1016/j.bbmt.2020.06.028. PMID: 32640312

Predicting Survival after Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis: Performance of the Myelofibrosis Transplant Scoring System (MTSS) and Development of a New Prognostic Model: Prognostication in myelofibrosis. Hernandez Boluda J, Pereira A, Alvarez-Larran A, Martin A, Benzaquen Vallejos A, Aguirre L, Mora E, Gonzalez P, Mora J, Dorado N, Sampol A, Garcia-Gutierrez V, Lopez-Godino O, Fox M, Reguera J, Perez-Encinas M, Pascual M, Xicoy B, Parody R, Gonzalez-Pinedo L, Espanol I, Avendano A, Correa J, Vallejo C, Jurado M, Garcia-Cadenas I, Osorio S, Duran M, Sanchez-Guijo F, Cervantes F, Pinana J. Biology of Blood and Marrow Transplantation. 2020 Dec;26(12):2237-2244. doi: 10.1016/j.bbmt.2020.07.022. PMID: 32717433

Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation. Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte R, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socie G, Solano Vercet C, Vrhovac R, Zeiser R, Kroger N, Basak G. Lancet Haematology. 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485

Prospective Randomized Study Comparing Myeloablative Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Stem Cell Transplantation for Adults with Hematologic Malignancies. Sanz J, Montoro J, Solano Vercet C, Valcarcel D, Sampol A, Ferra C, Parody R, Lorenzo I, Montesinos P, Orti G, Hernandez Boluda J, Balaguer-Rosello A, Guerreiro M, Carretero C, Sanz G, Sanz M, Pinana J. Biology of Blood and Marrow. 2020 Feb;26(2):358-366. doi: 10.1016/j.bbmt.2019.10.014. PMID: 31655119

Rabbit ATG/ATLG in preventing graft-versus-host disease after allogeneic stem cell transplantation: consensus-based recommendations by an international expert panel. Bonifazi F, Rubio M, Bacigalupo A, Boelens J, Finke J, Greinix H, Mohty M, Nagler A, Passweg J, Rambaldi A, Socie G, Solano Vercet C, Walker I, Barosi G, Kroeger N. Bone Marrow Transplantation. 2020 Jun;55(6):1093-1102. doi: 10.1038/s41409-020-0792-x. PMID: 31969678

Reconstitution of cytomegalovirus-specific T-cell immunity following unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Remigia Pellicer M, Amat Martínez P, Vazquez Lopez L, Hernandez M, Hernandez Boluda J, Gago B, Piñana Sanchez J, Garcia M, Perez Martinez A, Mateo Jimenez E, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1347-1356. doi: 10.1038/s41409-020-0865-x. PMID: 32205853

Risk factors and outcome of COVID-19 in patients with hematological malignancies. Pinana J, Martino R, Garcia-Garcia I, Parody R, Morales M, Benzo G, Gomez-Catalan I, Coll R, De la Fuente I, Luna A, Merchan B, Chinea A, de Miguel D, Serrano A, Perez C, Diaz C, Lopez J, Saez A, Bailen R, Zudaire T, Martinez D, Jurado M, Calbacho M, Vazquez L, Garcia-Cadenas I, Fox L, Pimentel A, Bautista G, Nieto A, Fernandez P, Vallejo J, Solano C, Valero M, Espigado I, Saldana R, Sisinni L, Ribera J, Jimenez M, Trabazo M, Gonzalez-Vicent M, Fernandez N, Talarn C, Montoya M, Cedillo A, Sureda A, Spanish Hematopoietic Stem Cell Tr. Experimental Hematology & Oncology. 2020 Aug 25;9:21. doi: 10.1186/s40164-020-00177-z. PMID: 32864192

SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patients. Gozalbo-Rovira R, Gimenez Quiles E, Latorre V, Frances-Gomez C, Albert Vicent E, Buesa Gomez J, Marina A, Blasco Cortes M, Signes-Costa Miñana J, Rodriguez Diaz J, Geller R, Navarro Ortega D. Journal of Clinical Virology. 2020 Oct;131:104611. doi: 10.1016/j.jcv.2020.104611. PMID: 32882666

The clinical benefit of instituting a prospective clinical community-acquired respiratory virus surveillance program in allogeneic hematopoietic stem cell transplantation. Pinana J, Montoro J, Aznar C, Lorenzo I, Dolores Gomez M, Guerreiro M, Carretero C, Maria Gonzalez-Barbera E, Balaguer-Rosello A, Sanz R, Salavert M, Navarro Ortega D, Sanz M, Sanz G, Sanz J. The Journal of infection. 2020 Mar;80(3):333-341. doi: 10.1016/j.jinf.2019.12.022. PMID: 31972212

The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey. Pinana J, Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Gimenez Quiles E, Gomez M, Guerreiro M, Gonzalez-Barbera E, Carretero C, Salavert M, Balaguer-Rosello A, Sanz G, Hernandez Boluda J, Solano Vercet C, Sanz J, Navarro Ortega D. Bone Marrow Transplantation. 2020 Feb;55(2):431-440. doi: 10.1038/s41409-019-0698-7. PMID: 31551521

Torque teno virus viremia in patients with chronic arthritis: Influence of biologic therapies. Martin-Lopez M, Albert Vicent E, Fernandez-Ruiz M, Gonzalez-Alvaro I, Rodriguez E, Aguado J, Navarro Ortega D, Pablos J. Seminars in Arthritis and Rheumatism. 2020 Feb;50(1):166-171. doi: 10.1016/j.semarthrit.2019.06.019

Uniform graft-versus-host disease prophylaxis with posttransplant cyclophosphamide, sirolimus, and mycophenolate mofetil following hematopoietic stem cell transplantation from haploidentical, matched sibling and unrelated donors. Montoro J, Pinana J, Hernandez Boluda J, Hernani Morales R, Lorenzo I, Perez Martinez A, Guerreiro M, Balaguer-Rosello A, Sanz G, Carretero C, Albert Vicent E, Navarro Ortega D, Sanz M, Solano Vercet C, Sanz J. Bone Marrow Transplantation. 2020 Nov;55(11):2147-2159. doi: 10.1038/s41409-020-0921-6. PMID: 32371901

Use of micafungin as antifungal prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Spain (GETH-MIC). Lopez-Sanchez C, Valcarcel D, Gomez V, Lopez-Jimenez J, Serrano D, Rubio V, Solano Vercet C, Vazquez L, Ruiz I, Grupo Espanol de Trasplante Hematopoyetico (GETH). Revista Espanola de Quimioterapia. 2020 Apr;33(2):110-115. doi: 10.37201/req/094.2019. PMID: 32056418

Proyectos
Referencia: PI21/01628
Título: Inmunobiología de células NK expandidas con criterios GMP de donantes seleccionados de banco de linfocitos para inmunoterapia adoptiva después de TPH alogénico o trasplante de órgano sólido
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Solano Vercet
Duración: 2022 – 2024
Presupuesto: 102.850 €
Referencia: BIO21/COV/030
Título: Estudio de la inmunidad y Creación de un Banco Nacional de Terapia Celular Adoptiva de donantes de linfocitos que han superado COVID-19. Ensayo clínico Fase I multicéntrico para evaluar la seguridad de la infusión de células natural killer como terapia adoptiva en casos pacientes con neumonía y/o linfopenia debido al coronavirus SARS-CoV-2 (RELEASE)
Entidad Financiadora: Fundación Vasca de Innovación e investigación Sanitarias (BIOEFF)
Investigador principal: Cristina Eguizabal
Duración: 2021 – 2022
Presupuesto: 99.935 €
Referencia: ICI21/00016
Título: Terapia celular combinada para pacientes COVID-19 de alto riesgo de mortalidad (DECODE-19)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Bernat Soria Escoms
Duración: 2021 – 2024
Presupuesto: 459.800 €
Referencia: PI-2021-004
Título: TECO: Validación de dos sistemas biosensor para la diagnosis simultánea de covid19 y otros patógenos aéreos
Entidad Financiadora: Universidad de Valencia – INCLIVA
Investigador principal: David Giménez Romero, Estela Giménez Quiles
Duración: 2021 – 2022
Presupuesto: 19.000 €
Referencia: GV/2020/188
Título: Anellovirus y Pegivirus un posible marcador del estado neto de inmunosupresión: evaluación en el trasplante alogénico de progenitores hematopoyéticos
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Estela Giménez Quiles
Duración: 2020 – 2021
Presupuesto: 16.000 €
Referencia: AP178182020
Título: Estudio de la inmunidad y Creación de un Banco Nacional de Terapia Celular Adoptiva de donantes de linfocitos que han superado COVID-19. Ensayo clínico Fase I multicéntrico para evaluar la seguridad de la infusión de células natural killer como terapia adoptiva en casos pacientes con neumonía y/o linfopenia debido al coronavirus SARS-CoV-2 (RELEASE)
Entidad Financiadora: Fundación Mutua Madrileña
Investigador principal: Cristina Eguizabal
Duración: 2020 – 2021
Presupuesto: 100.000 €
Referencia: PI18/01473
Título: Inmunología de la infusión de linfocitos del donante con depleción ex vivo de linfocitos t cd45ra+ en pacientes con alto riesgo de infección viral tras TPH alogénico
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Solano Vercet
Duración: 2019 – 2023
Presupuesto: 123.420 €
Referencia: PI17/01097
Título: Score integrado de factores inmunológicos y genotípicos de predicción del riesgo y evolución de la infección por CMV en pacientes con trasplante renal
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: María José Remigia Pellicer
Duración: 2018 – 2022
Presupuesto: 32.670 €
Referencia: PI15/01396
Título: Inmunobiología de la aloreactividad NK en el trasplante de progenitores hematopoyéticos haploidenticos asociado al uso de ciclofosfamida post-trasplante
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Solano Vercet
Duración: 2016 – 2019
Presupuesto: 116.765 €
Referencia: PI15/00090
Título: Inmunobiología de la infección por el citomegalovirus en el trasplante alogénico de precursores hematopoyéticos haploidéntico asociado al uso de ciclofosfamida postrasplante
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: David Navarro Ortega
Duración: 2016 – 2019
Presupuesto: 98.615 €
+ Información
Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7). Ljungman P, de la Camara R, Robin C, Crocchiolo R, Einsele H, Hill JA6, Hubacek P7, Navarro D8, Cordonnier C3, Ward KN9; 2017 European Conference on Infections in Leukaemia group. LANCET INFECTIOUS DISEASES. 2019 Aug; 19(8): e260-e272. doi: 10.1016/S1473-3099(19)30107-0. PMID: 31153807

Título: Impacto de la alorreactividad NK en el trasplante haploidéntico de progenitores hematopoyéticos asociado al uso de la ciclofosfamida postrasplante
Doctorando: Luis Hidalgo, Mª Mar
Director: Solano Vercet, Carlos; Piñana Sánchez, Jose Luis; Planelles Silvestre, Dolores
Fecha: 21/12/2022
Universidad: Universitat de València

Título: Significado pronóstico de la expresión del factor de crecimiento endotelial vascular (VEGF) y de genes implicados en las vías de señalización del VEGF en pacientes con leucemia aguda mieloblástica
Doctorando: Calabuig Muñoz, Marisa
Director: Tormo Díaz, Mar; Solano Vercet, Carlos
Fecha: 04/05/2022
Universidad: Universitat de València

Título: Factores predictivos de desarrollo y evolución de infección activa por citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
Doctorando: Vinuesa Velasco, Víctor
Director: Navarro Ortega, David
Fecha: 08/09/2021
Universidad: Universitat de València

Título: Estudio de la enfermedad residual mínima en pacientes con mieloma múltiple en muy buena respuesta parcial o completa convencional mediante citometría de flujo de alta sensibilidad y la medición de cadenas mediante la técnica Hevylite
Doctorando: Remigia Pellicer, María José
Director: De la Rubia Comos, Javier; Sempere Talens, Amparo; Solano Vercet, Carlos
Fecha: 04/06/2021
Universidad: Universitat de València

Título: Parámetros biológicos predictivos de la infección activa precoz por Citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
Doctorando: Talaya Peñalver, Alberto
Director: Navarro Ortega, David
Fecha: 26/05/2021
Universidad: Universitat de València

Título: Torque teno virus como marcador subrogado de inmunocompetencia en el trasplante
Doctorando: Albert Vicent, Eliseo
Director: Navarro Ortega, David
Fecha: 13/02/2020
Universidad: Universitat de València

Título: Concentración mínima inhibitoria de vancomicina para staphylococcus aureus y riesgo de bacteriemia complicada
Doctorando: Falcón Abad, Rocío
Director: Navarro Ortega, David
Fecha: 02/10/2019
Universidad: Universitat de València