Dr. Carlos Solano Vercet

Investigador Principal
Grupo de Investigación en Trasplante Hematopoyético

Presentación

Jefe del Servicio de Hematología y Hemoterapia y Director del Programa de Trasplante Hematopoyético y Terapia Celular del Hospital Clínico Universitario de Valencia. Catedrático de Medicina, Departamento de Medicina. Facultad de Medicina de la Universidad de Valencia.

Se licenció en Medicina y Cirugía por la Universidad de Valencia. Realizó la Residencia en Hematología y Hemoterapia en el Hospital Universitario La Princesa de Madrid. Después de dos estancias de investigación en el Hospital Hammersmith, Londres y el Medical Center de UCLA, Los Angeles-CA, en 1990 se incorporó como Médico Adjunto de Hematología del Hospital Clínico Universitario de Valencia. Obtuvo el doctorado en Medicina por la Universidad de Valencia en 1996, realizando investigación sobre la recuperación inmune después de trasplante hematopoyético.

Ha sido Presidente del Grupo Español de Trasplante Hematopoyético y Terapia Celular (GETH) y Coordinador de los Comités de Inmunoterapia/Enfermedad injerto contra receptor y de Normativa y Acreditación del GETH. Vicepresidente de la Comisión Nacional de la Especialidad de Hematología y Hemoterapia.

Es autor de más de 250 artículos originales en revistas de la especialidad, con especial interés en la investigación de la biología y tratamiento de la enfermedad injerto contra receptor y de las complicaciones infecciosas del paciente inmunodeprimido.

Dr. Carlos Solano Vercet
Investigador
Principal
Dr. Carlos Solano Vercet

carlos.solano@uv.es

Publicaciones
Cytomegalovirus DNAemia in hematological patients undergoing CD19-directed CAR-T cell therapy: should it be systematically monitored?. Solano de la Asuncion C, Hernani R, Albert E, Gomez M, Gimenez E, Benzaquen A, Gonzalez-Barbera E, Hernandez-Boluda J, Perez A, Pinana J, Chorao P, Guerreiro M, Montoro J, Sanz J, Solano C, Navarro D. Clinical Microbiology and Infection. 2023 May 12;S1198-743X(23)00234-3. doi: 10.1016/j.cmi.2023.05.010. PMID: 37182642

Features of cytomegalovirus DNAemia and virus-specific T-cell responses in allogeneic hematopoietic stem-cell transplant recipients during prophylaxis with letermovir. Gimenez E, Guerreiro M, Torres I, Aguilar C, Albert E, Hernandez-Boluda JC, Hernani R, Perez A, Amat P, Pinana JL, Montoro J, Solano C, Navarro D. Transplant Infectious Disease. 2023 Apr;25(2):e14021. doi: 10.1111/tid.14021. PMID: 36748748

Immunobiology of cytomegalovirus infection in patients with haematological malignancies undergoing treatment with small molecule inhibitors. Solano De la Asuncion C, Gimenez E, Hernandez-Boluda JC, Terol MJ, Albert E, Lopez-Jimenez J, Garcia-Gutierrez V, Andreu R, Garcia D, Fox ML, Remigia MJ, Amat P, Solano C, Navarro D. British Journal of Haematology. 2023 Mar;200(6):e58-e61. doi: 10.1111/bjh.18655. PMID: 36652997

Impact of cytomegalovirus immunodominant HLA-I donor-recipient matching on the incidence and features of virus DNAemia and virus-specific T-cell immune reconstitution in unmanipulated haploidentical hematopoietic stem cell transplantation. Huntley D, Gimenez E, Vazquez L, Pascual M, Amat P, Remigia M, Hernandez-Boluda J, Garcia M, Gago B, Torres I, de la Asuncion C, Hernani R, Perez A, Albert E, Pinana J, Solano C, Navarro D. Transplant Infectious Disease. 2023 Apr 30;e14065. doi: 10.1111/tid.14065. PMID: 37120821

Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry. Ljungman P, Tridello G, Pinana J, Ciceri F, Sengeloev H, Kulagin A, Mielke S, Yegin Z, Collin M, Einardottir S, Lepretre S, Maertens J, Campos A, Metafuni E, Pichler H, Folber F, Solano C, Nicholson E, Yuksel M, Carlson K, Aguado B, Besley C, Byrne J, Heras I, Dignan F, Kroger N, Robin C, Khan A, Lenhoff S, Grassi A, Dobsinska V, Miranda N, Jimenez M, Yonal-Hindilerden I, Wilson K, Averbuch D, Cesaro S, Xhaard A, Knelange N, Styczynski J, Mikulska M, de la Camara R. Frontiers in Immunology. 2023 Mar 7;14:1125824. doi: 10.3389/fimmu.2023.1125824. PMID: 36960069

Monitoring for virus-specific T-cell responses and viremia in allogeneic HSCT recipients: a survey from the EBMT Cellular Therapy & Immunobiology Working Party. Greco R, Hoogenboom JD, Bonneville EF, Anagnostopoulos A, Cuoghi A, Dalle JH, Weissinger EM, Lang P, Galaverna F, Martino M, Maschan A, Mauz-Korholz C, Noviello M, Passweg J, Peccatori J, Rovira M, Solano C, Veelken H, Velardi A, Wagner-Drouet EM, Zhang X, Ciceri F, Bonini C, Vago L, Ruggeri A, Chabannon C. Bone Marrow Transplantation. 2023 May;58(5):603-606. doi: 10.1038/s41409-023-01939-z. PMID: 36813866

One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients. Pinana JL, Vazquez L, Calabuig M, Lopez-Corral L, Martin-Martin G, Villalon L, Sanz-Linares G, Conesa-Garcia V, Sanchez-Salinas A, Gago B, Facal A, Risco-Galvez I, Olave MT, Espigado I, Lopez-Jimenez J, Hernandez-Rivas JA, Avendano-Pita A, Arroyo I, Ferrer E, Garcia-Cadenas I, Gonzalez-Santillana C, Roldan-Perez A, Ferrer B, Guerreiro M, Suarez-Lledo M, Camara A, Campos-Beltran D, Navarro D, Cedillo A, Sureda A, Solano C, Martino R. Blood Cancer Journal. 2023 Jan 5;13(1):8. doi: 10.1038/s41408-022-00778-3. PMID: 36599843

SARS-CoV-2-reactive antibody waning, booster effect and breakthrough SARS-CoV-2 infection in hematopoietic stem cell transplant and cell therapy recipients at one year after vaccination. Pinana J, Martino R, Vazquez L, Lopez-Corral L, Perez A, Chorao P, Avendano Pita A, Pascual M, Sanchez Salinas A, Sanz Linares G, Olave M, Arroyo I, Tormo M, Villalon L, Conesa Garcia V, Gago B, Terol M, Villalba M, Garcia Gutierrez V, Cabero A, Hernandez Rivas J, Ferrer E, Garcia Cadenas I, Teruel A, Navarro D, Cedillo A, Sureda A, Solano C. Bone Marrow Transplantation. 2023 Feb 28;1-14. doi: 10.1038/s41409-023-01946-0. PMID: 36854892

Allogeneic stem cell transplantation in mantle cell lymphoma; insights into its potential role in the era of new immunotherapeutic and targeted therapies: the GETH/GELTAMO experience. Gutierrez A, Bento L, Novelli S, Martin A, Gutierrez G, Salas M, Bastos-Oreiro M, Perez A, Hernani R, Viguria M, Lopez-Godino O, Montoro J, Pinana J, Ferra C, Parody R, Martin C, Espanol I, Yanez L, Rodriguez G, Zanabili J, Herrera P, Varela M, Sampol A, Solano C, Caballero D. Cancers. 2022 May 27;14(11):2673. doi: 10.3390/cancers14112673. PMID: 35681653

Applicability of probabilistic graphical models for early detection of SARS-CoV-2 reactive antibodies after SARS-CoV-2 vaccination in hematological patients. Pinana J, Rodriguez-Belenguer P, Caballero D, Martino R, Lopez-Corral L, Terol M, Vazquez L, Calabuig M, Sanz-Linares G, Marin-Jimenez F, Alonso C, Montoro J, Ferrer E, Facal A, Pascual M, Rodriguez-Fernandez A, Olave M, Cascales-Hernandez A, Gago B, Hernandez-Rivas J, Villalon L, Corona M, Roldan-Perez A, Ribes-Amoros J, Gonzalez-Santillana C, Garcia-Sanz R, Navarro D, Serrano-Lopez A, Cedillo A, Soria-Olivas E, Sureda A, Solano C. Annals of Hematology. 2022 Sep;101(9):2053-2067. doi: 10.1007/s00277-022-04906-8. PMID: 35780254

Booster effect after SARS-CoV-2 vaccination in immunocompromised hematology patients with prior COVID-19. Piñana JL, Garcia-Sanz R, Martino R, Garcia-Roa M, Martin-Martin GA, Risco-Gálvez I, Tormo M, Martinez-Barranco P, Marcos-Corrales S, Calabuig M, Conesa V, Teruel A, Ruiz-Pérez S, Solano C, Navarro D, Cedillo Á, Sureda A. Blood Advances. 2022 Jan 8;6(3):848-853. doi: 10.1182/bloodadvances.2021006326. PMID: 34905620

Identifying SARS-CoV-2 ‘memory’ NK cells from COVID-19 convalescent donors for adoptive cell therapy. Herrera L, Martin-Inaraja M, Santos S, Ingles-Ferrandiz M, Azkarate A, Perez-Vaquero MA, Vesga MA, Vicario JL, Soria B, Solano C, De Paz R, Marcos A, Ferreras C, Perez-Martinez A, Eguizabal C. Immunology. 2022 Feb;165(2):234-249. doi: 10.1111/imm.13432. doi: 10.1111/imm.13432. PMID: 34775592

Multi-body-site colonization screening cultures for predicting multi-drug resistant Gram-negative and Gram-positive bacteremia in hematological patients. Torres I, Huntley D, Tormo M, Calabuig M, Hernandez-Boluda J, Terol M, Carretero C, de Michelena P, Perez A, Pinana J, Colomina J, Solano C, Navarro D. BMC Infectious Diseases. 2022 Feb 21;22(1):172. doi: 10.1186/s12879-022-07154-3. PMID: 35189833

Post-transplant cyclophosphamide and sirolimus based graft-versus-host disease prophylaxis after allogeneic stem cell transplantation for acute myeloid leukemia. Lazzari L, Balaguer-Rosello A, Montoro J, Greco R, Hernani R, Lupo-Stanghellini M, Villalba M, Giglio F, Facal A, Lorentino F, Guerreiro M, Bruno A, Perez A, Xue E, Clerici D, Piemontese S, Pinana J, Sanz M, Solano C, de la Rubia J, Ciceri F, Peccatori J, Sanz J. Bone Marrow Transplantation. 2022 Sep;57(9):1389-1398. doi: 10.1038/s41409-022-01725-3. PMID: 35680995

SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders. Pinana JL, Lopez-Corral L, Martino R, Vazquez L, Perez A, Martin-Martin G, Gago B, Sanz-Linares G, Sanchez-Salinas A, Villalon L, Conesa-Garcia V, Olave MT, Corona M, Marcos-Corrales S, Tormo M, Hernandez-Rivas JA, Montoro J, Rodriguez-Fernandez A, Risco-Galvez I, Rodriguez-Belenguer P, Hernandez-Boluda JC, Garcia-Cadenas I, Ruiz-Garcia M, Munoz-Bellido JL, Solano C, Cedillo A, Sureda A, Navarro D. Journal of Hematology & Oncology. 2022 May 7;15(1):54. doi: 10.1186/s13045-022-01275-7. PMID: 35526045

SARS-CoV-2-reactive antibody detection after SARS-CoV-2 vaccination in hematopoietic stem cell transplant recipients: Prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC). Pinana J, Lopez-Corral L, Martino R, Montoro J, Vazquez L, Perez A, Martin-Martin G, Facal-Malvar A, Ferrer E, Pascual M, Sanz-Linares G, Gago B, Sanchez-Salinas A, Villalon L, Conesa-Garcia V, Olave M, Lopez-Jimenez J, Marcos-Corrales S, Garcia-Blazquez M, Garcia-Gutierrez V, Hernandez-Rivas J, Saus A, Espigado I, Alonso C, Hernani R, Solano C, Ferrer-Lores B, Guerreiro M, Ruiz-Garcia M, Munoz-Bellido J, Navarro D, Cedillo A, Sureda A, Infectious Complications Subcommittee of the Spanish Hematopoietic Stem, Cell Transplantation and Cell Therapy Group (GETH-TC). American Journal of Hematology. 2022 Jan 1;97(1):30-42. doi: 10.1002/ajh.26385. PMID: 34695229

Toxicities following CAR-T therapy for hematological malignancies. Hernani R, Benzaquen A, Solano C. Cancer Treatment Reviews. 2022 Dec;111:102479. doi: 10.1016/j.ctrv.2022.102479. PMID: 36308910

A phase I/II dose-escalation multi-center study to evaluate the safety of infusion of natural killer cells or memory T cells as adoptive therapy in coronavirus pneumonia and/or lymphopenia: RELEASE study protocol. García-García I, Guerra-García P, Ferreras C, Borobia A, Carcas A, Queiruga-Parada J, Vicario J, Mirones I, Solano Vercet C, Eguizabal C, Soria B, Pérez-Martínez A. Trials. 2021 Oct 2;22(1):674. doi: 10.1186/s13063-021-05625-7. PMID: 34600562

Addition of rituximab in reduced intensity conditioning regimens for B-Cell malignancies does not influence transplant outcomes: EBMT registry analyses following allogeneic stem cell transplantation for B-Cell malignancies. Tomaszewska A, Jagasia M, Beohou E, van der Werf S, Blaise D, Kanfer E, Milpied N, Remenyi P, Ciceri F, Bourhis J, Chevallier P, Solano C, Socie G, Bruno B, Rambaldi A, Castagna L, Kroger N, Corradini P, Afanasyev B, Ladetto M, Niederwieser D, Scheid C, Sengeloev H, Kroschinsky F, Yakoub-Agha I, Schoemans H, Koenecke C, Penack O, Peric Z, Greinix H, Duarte R, Basak G. Frontiers in Immunology. 2021 Feb 2;11:613954. doi: 10.3389/fimmu.2020.613954. PMID: 33603743

Allogeneic Hematopoietic Stem Cell Transplant recipients in Spain: Human Leucocyte Antigen characteristics and diversity by high-resolution analysis. Guerreiro M, Planelles D, Aguilar-Gallardo C, Lorenzo J, Montoro J, Sanz J, Balaguer A, Gomez I, Solves P, Perez A, Blanquer M, Espigado I, Solano C, Pinana J, Grupo Espanol de Trasplante Hematopoyetico y Terapia Celular (GETH). HLA. 2021 Mar;97(3):198-213. doi: 10.1111/tan.14179. PMID: 33369244

Amplification of human beta-glucoronidase gene for appraising the accuracy of negative SARS-CoV-2 RT-PCR results in upper respiratory tract specimens. Albert Vicent E, Ferrer Lores B, Torres Fink I, Serrano Alcalá A, Alcaráz Soriana M, Buesa Gomez J, Solano Vercet C, Colomina Rodríguez F, Bueno Ferrando F, Huntley Pascual D, Olea Miguel B, Valdivia Piqueres A, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):48-50. doi: 10.1002/jmv.26112. PMID: 32484950

An investigation of the potential association between gastrointestinal viral and bacterial infection and development of intestinal acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. Bueno F, Albert E, Gimenez E, Pinana J, Perez A, Gomez M, Hernandez-Boluda J, Gonzalez-Barbera E, Montoro J, Buesa J, Guerreiro M, Balaguer-Rosello A, Hernani R, Sanz J, Solano C, Navarro D. Journal of Medical Virology. 2021 Aug;93(8):4773-4779. doi: 10.1002/jmv.26892. PMID: 33605457

Biomarker profile predicts clinical efficacy of extracorporeal photopheresis in steroid-resistant acute and chronic graft-vs-host disease after allogenic hematopoietic stem cell transplant. Amat P, Lopez-Corral L, Goterris R, Perez A, Lopez O, Heras I, Arbona C, Viguria MC, Hernandez-Boluda JC, Martinez-Ruiz F, Martinez A, Solano C. Journal of Clinical Apheresis. 2021 Oct;36(5):697-710. doi: 10.1002/jca.21918. PMID: 34185332

CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review. Hernani R, Sancho A, Amat P, Hernandez-Boluda J, Perez A, Pinana J, Carretero C, Goterris R, Gomez M, Saus A, Ferrer B, Teruel A, Terol M, Solano C. Current Research in Translational Medicine. 2021 Jul 22;69(4):103304. doi: 10.1016/j.retram.2021.103304. PMID: 34303899

Clinical outcomes of allogeneic hematopoietic stem cell transplant recipients developing Cytomegalovirus DNAemia prior to engraftment. Solano C, Vazquez L, Gimenez E, de la Camara R, Albert E, Rovira M, Espigado I, Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Pinana J, Navarro D, Spanish Group of Hematopoietic Transplantation and Cell Therapy (GETH). Bone Marrow Transplantation. 2021 Jun;56(6):1281-1290. doi: 10.1038/s41409-020-01157-x. PMID: 33319853

Cytomegalovirus DNAemia and risk of mortality in allogeneic hematopoietic stem cell transplantation: Analysis from the Spanish Hematopoietic Transplantation and Cell Therapy Group. Solano Vercet C, Vazquez L, Gimenez Quiles E, De La Camara R, Albert Vicent E, Rovira M, Espigado I, Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez Martinez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Bautista G, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Pinana J, Navarro Ortega D. American Journal of Transplantation. 2021 Jan;21(1):258-271. doi: 10.1111/ajt.16147. PMID: 32812351

Cytomegalovirus-specific T-cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib. De la Asuncion C, Terol M, Saus A, Olea B, Gimenez E, Albert E, Lopez-Jimenez J, Andreu R, Garcia D, Fox L, Remigia M, Amat P, Solano C, Navarro D. British Journal of Haematology. 2021 Nov;195(4):637-641. doi: 10.1111/bjh.17732. PMID: 34402042

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2021 Aug;93(8):5167-5172. doi: 10.1002/jmv.26661. PMID: 33174620

Hospital and outpatient models for Hematopoietic Stem Cell Transplantation: a systematic review of comparative studies for health outcomes, experience of care and costs. Gonzalez M, Urizar E, Urtaran-Laresgoiti M, Nuno-Solinis R, Lazaro-Perez E, Vazquez L, Pascual-Cascon M, Solano C, Kwon M, Gallego C, Fernandez-Aviles F. PLoS One. 2021 Aug 12;16(8):e0254135. doi: 10.1371/journal.pone.0254135. PMID: 34383780

Myelodysplastic syndromes with 20q deletion: incidence, prognostic value and impact on response to azacitidine of ASXL1 chromosomal deletion and genetic mutations. Martin I, Villamon E, Abellan R, Calasanz M, Irigoyen A, Sanz G, Such E, Mora E, Gutierrez M, Collado R, Garcia-Serra R, Vara M, Blanco M, Oiartzabal I, Alvarez S, Bernal T, Granada I, Xicoy B, Jerez A, Calabuig M, Diez R, Gil A, Diez-Campelo M, Solano C, Tormo M, Spanish Grp Myelodysplastic Syn. British Journal of Haematology. 2021 Aug;194(4):708-717. doi: 10.1111/bjh.17675. PMID: 34296432

Real-world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B-cell lymphoma. Cancer medicine. Iacoboni G, Villacampa G, Martinez-Cibrian N, Bailen R, Lopez Corral L, Sanchez J, Guerreiro M, Caballero A, Mussetti A, Sancho J, Hernani Morales R, Abrisqueta P, Solano Vercet C, Sureda A, Briones J, Martin Garcia-Sancho A, Kwon M, Reguera-Ortega J, Barba P, GETH G. 2021 May;10(10):3214-3223. doi: 10.1002/cam4.3881. PMID: 33932100

SARS-CoV-2-reactive interferon-gamma-producing CD8+ T cells in patients hospitalized with Coronavirus Disease 2019. Gimenez Quiles E, Albert Vicent E, Torres Fink I, Remigia Pellicer M, Alcaráz Soriana M, Galindo Puerto M, Blasco Cortes M, Solano Vercet C, Forner Giner M, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):375-382. doi: 10.1002/jmv.26213. PMID: 32579268

SARS-CoV-2-specific memory t lymphocytes from COVID-19 convalescent donors: identification, biobanking, and large-scale production for adoptive cell therapy. Ferreras C, Pascual-Miguel B, Mestre-Duran C, Navarro-Zapata A, Clares-Villa L, Martin-Cortazar C, De Paz R, Marcos A, Vicario J, Balas A, Garcia-Sanchez F, Eguizabal C, Solano C, Mora-Rillo M, Soria B, Perez-Martinez A. Frontiers in Cell and Developmental Biology. 2021 Feb 25;9:620730. doi: 10.3389/fcell.2021.620730. PMID: 33718360

Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. Pinana J, Xhaard A, Tridello G, Passweg J, Kozijn A, Polverelli N, Heras I, Perez A, Sanz J, Berghuis D, Vazquez L, Suarez-Lledo M, Itala-Remes M, Ozcelik T, Iturrate Basaran I, Karakukcu M, Al Zahrani M, Choi G, Cuesta Casas M, Batlle Massana M, Viviana A, Blijlevens N, Ganser A, Kuskonmaz B, Labussiere-Wallet H, Shaw P, Arzu Yegin Z, Gonzalez-Vicent M, Rocha V, Ferster A, Knelange N, Navarro D, Mikulska M, de la Camara R, Styczynski J, Infectious Diseases Working Party of the European Society for Blood and, Marrow Transplantation and Infectious Complications Subcommittee of the, Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group, (GETH). The Journal of Infectious Diseases. 2021 May 20;223(9):1564-1575. doi: 10.1093/infdis/jiaa553. PMID: 32860509

Use of letermovir in off-label indications: Infectious Diseases Working Party of European Society of Blood and Marrow Transplantation retrospective study. Styczynski J, Tridello G, Xhaard A, Medinger M, Mielke S, Taskinen M, Blijlevens N, Rodriguez M, Solano C, Nikolousis E, Biffi A, Groll A, Junghanss C, Tsirigotis P, Lioure B, Sramek J, Holler E, Galaverna F, Fagioli F, Knelange N, Wendel L, Gil L, de la Camara R, Mikulska M, Ljungman P. Bone Marrow Transplantation. 2021 May;56(5):1171-1179. doi: 10.1038/s41409-020-01166-w. PMID: 33288863

An investigation of the utility of plasma Cytomegalovirus (CMV) microRNA detection to predict CMV DNAemia in allogeneic hematopoietic stem cell transplant recipients. Talaya Peñalver A, Gimenez Quiles E, Pascual M, Gago B, Piñana Sanchez J, Hernandez Boluda J, Vazquez L, Garcia M, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Medical Microbiology And Immunology. 2020 Feb;209(1):15-21. doi: 10.1007/s00430-019-00632-7. PMID: 31478067

Assessing the impact on intestinal microbiome and clinical outcomes of antibiotherapy optimisation strategies in haematopoietic stem cell transplant recipients: study protocol for the prospective multicentre OptimBioma study. Jimenez-Jorge S, Labrador-Herrera G, Rosso-Fernandez C, Rodriguez-Torres N, Pachon-Ibanez M, Smani Y, Marquez-Malaver F, Limon Ramos C, Solano Vercet C, Vazquez-Lopez L, Kwon M, Mora Barrios J, Aguilar-Guisado M, Espigado I, GETH (Grupo Espanol de Trasplante Hematopoyetico y Terapia Celular). BMJ Open. 2020 Jul 20;10(7):e034570. doi: 10.1136/bmjopen-2019-034570. PMID: 32690735

Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell transplantation. Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Hernandez Boluda J, Gimenez Quiles E, Gomez M, Balaguer-Rosello A, Gonzalez-Barbera E, Guerreiro M, Aguilar C, Navarro Ortega D, Solano Vercet C, Sanz J, Luis Pinana J. Transplant Infectious Disease. 2020 Aug;22(4):e13301. doi: 10.1111/tid.13301. PMID: 32363665

Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) (vol 55, pg 681, 2019). Snowden J, Saccardi R, Orchard K, Ljungman P, Duarte R, Labopin M, McGrath E, Brook N, de Elvira C, Gordon D, Poirel H, Ayuk F, Beguin Y, Bonifazi F, Gratwohl A, Milpied N, Moore J, Passweg J, Rizzo J, Spellman S, Sierra J, Solano Vercet C, Sanchez-Guijo F, Worel N, Gusi A, Adams G, Balan T, Baldomero H, Macq G, Marry E, Mesnil F, Oldani E, Pearce R, Perry J, Raus N, Schanz U, Tran S, Wilcox L, Basak G, Chabannon C, Corbacioglu S, Dolstra H, Kuball J, Mohty M, Lankester A, Montoto S, Nagler A, Styczynski J, Yakoub-Agha I, de Latour R, Kroeger N, Brand R, de Wreede L, van Zwet E, Putter H. Bone Marrow Transplantation. 2020 Apr;55(4):838-839. doi: 10.1038/s41409-019-0740-9. PMID: 31754251

Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Snowden J, Saccardi R, Orchard K, Ljungman P, Duarte R, Labopin M, McGrath E, Brook N, de Elvira C, Gordon D, Poirel H, Ayuk F, Beguin Y, Bonifazi F, Gratwohl A, Milpied N, Moore J, Passweg J, Rizzo J, Spellman S, Sierra J, Solano Vercet C, Sanchez-Guijo F, Worel N, Gusi A, Adams G, Balan T, Baldomero H, Macq G, Marry E, Mesnil F, Oldani E, Pearce R, Perry J, Raus N, Schanz U, Tran S, Wilcox L, Basak G, Chabannon C, Corbacioglu S, Dolstra H, Kuball J, Mohty M, Lankester A, Montoto S, Nagler A, Styczynski J, Yakoub-Agha I, de Latour R, Kroeger N, Brand R, de Wreede L, van Zwet E, Putter H. Bone Marrow Transplantation. 2020 Apr;55(4):681-694. doi: 10.1038/s41409-019-0718-7. PMID: 31636397

Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens. Luis Pinana J, Albert Vicent E, Dolores Gomez M, Perez Martinez A, Hernandez Boluda J, Montoro J, Salavert M, Maria Gonzalez E, Tormo Diaz M, Gimenez Quiles E, Villalba M, Balaguer-Rosello A, Hernani Morales R, Bueno Ferrando F, Borras Salvador R, Sanz J, Solano Vercet C, Navarro Ortega D. The Journal of infection. 2020 May;80(5):578-606. doi: 10.1016/j.jinf.2020.01.001. PMID: 31926954

Cytomegalovirus DNA load monitoring in stool specimens for anticipating the occurrence of intestinal acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: Is it of any value?. Bueno Ferrando F, Albert Vicent E, Gimenez Quiles E, Pinana J, Perez Martinez A, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Aug 9;e13440. doi: 10.1111/tid.13440. PMID: 32772456

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Network for Research in Infectious Diseases (REIPI) and the Spanish Society of Haematology and Haemotherapy (SEHH) on the management of febrile neutropenia in patients with hematological malignancies. Gudiol C, Aguilar-Guisado M, Azanza J, Candel F, Cantón R, Carratalà J, Garcia-Vidal C, Jarque I, Lizasoain M, Gil-Bermejo J, Ruiz-Camps I, Sánchez-Ortega I, Solano Vercet C, Suárez-Lledó M, Vázquez L, De La Cámara R. Enfermedades Infecciosas y Microbiologia Clinica. 2020 Apr;38(4):174-181. doi: 10.1016/j.eimc.2019.01.013. PMID: 30926172

Feasibility of thiotepa addition to the fludarabine-busulfan conditioning with tacrolimus/sirolimus as graft vs host disease prophylaxis. Fox M, Garcia-Cadenas I, Perez Martinez A, Villacampa G, Pinana J, Orti G, Montoro J, Roldan E, Bosch Vilaseca A, Martino R, Salamero O, Saavedra S, Hernandez Boluda J, Esquirol A, Sierra J, Sanz J, Solano Vercet C, Bosch F, Barba P, Valcarcel D. Leukemia & Lymphoma. 2020 Aug;61(8):1823-1832. doi: 10.1080/10428194.2020.1788015. PMID: 32654570

Features of Cytomegalovirus DNAemia Blips in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Implications for Optimization of Preemptive Antiviral Therapy Strategies. Huntley Pascual D, Talaya Peñalver A, Gimenez Quiles E, Perez Martinez A, Hernandez Boluda J, Hernani Morales R, Torres Fink I, Alberola J, Albert Vicent E, Piñana Sanchez J, Solano Vercet C, Navarro Ortega D. Biology of Blood and Marrow Transplantation. 2020 May;26(5):972-977. doi: 10.1016/j.bbmt.2020.01.015. PMID: 32007638

Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium. Sanchez-Maldonado J, Campa D, Springer J, Badiola J, Niazi Y, Moniz-Diez A, Hernandez-Mohedo F, Gonzalez-Sierra P, Ter Horst R, Macauda A, Brezina S, Cunha C, Lackner M, Lopez-Nevot M, Fianchi L, Pagano L, Lopez-Fernandez E, Potenza L, Luppi M, Moratalla L, Rodriguez-Sevilla J, Fonseca J, Tormo Diaz M, Solano Vercet C, Clavero E, Romero A, Li Y, Lass-Florl C, Einsele H, Vazquez L, Loeffler J, Hemminki K, Carvalho A, Netea M, Gsur A, Dumontet C, Canzian F, Forsti A, Jurado M, Sainz J. Blood Cancer Journal. 2020 Jul 16;10(7):75. doi: 10.1038/s41408-020-00341-y. PMID: 32678078

Impact of clinical features, cytogenetics, genetic mutations, and methylation dynamics of CDKN2B and DLC-1 promoters on treatment response to azacitidine. Martin Gonzalez I, Navarro Cubells B, Serrano Alcalá A, Villamón Ribate E, Calabuig Muñoz M, Solano Vercet C, Chaves Martínez F, Yague N, Orts M, Amat Martínez P, Fuentes Trillo A, Seda García E, García García F, Hernandez Boluda J, Tormo Diaz M. Annals of Hematology. 2020 Mar;99(3):527-537. doi: 10.1007/s00277-020-03932-8. PMID: 31989250

Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with post-transplantation cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Jesus Pascual M, Hernandez Boluda J, Gago B, Vazquez Lopez L, Luis Pinana J, Garcia M, Perez Martinez A, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Feb;22(1):e13206. doi: 10.1111/tid.13206. PMID: 31677215

Peripheral blood regulatory T cells and occurrence of Cytomegalovirus DNAemia after unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Vázquez L, Amat Martínez P, Remigia Pellicer M, Hernández M, Hernandez Boluda J, Gago B, Piñana Sanchez J, García M, Perez Martinez A, Alberola J, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1493-1496. doi: 10.1038/s41409-020-0950-1. PMID: 32447351

Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis. Lupianez C, Martinez-Bueno M, Sanchez-Maldonado J, Badiola J, Cunha C, Springer J, Lackner M, Segura-Catena J, Canet L, Alcazar-Fuoli L, Lopez-Nevot M, Fianchi L, Aguado J, Pagano L, Lopez-Fernandez E, Alarcon-Riquelme M, Potenza L, Goncalves S, Luppi M, Moratalla L, Solano Vercet C, Sampedro A, Gonzalez-Sierra P, Cuenca-Estrella M, Lagrou K, Maertens J, Lass-Floerl C, Einsele H, Vazquez L, Loeffler J, Rios-Tamayo R, Carvalho A, Jurado M, Sainz J. Infection and Immunity. 2020 Mar 23;88(4):e00882-19. doi: 10.1128/IAI.00882-19. PMID: 31964743

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium. Sanchez-Maldonado J, Moniz-Diez A, Ter Horst R, Campa D, Cabrera-Serrano A, Martinez-Bueno M, Garrido-Collado M, Hernandez-Mohedo F, Fernandez-Puerta L, Lopez-Nevot M, Cunha C, Gonzalez-Sierra P, Springer J, Lackner M, Alcazar-Fuoli L, Fianchi L, Aguado J, Pagano L, Lopez-Fernandez E, Clavero E, Potenza L, Luppi M, Moratalla L, Solano C, Sampedro A, Cuenca-Estrella M, Lass-Florl C, Pcraga Study Group, Canzian F, Loeffler J, Li Y, Einsele H, Netea M, Vazquez L, Carvalho A, Jurado M, Sainz J. Journal Of Fungi. 2020 Dec 23;7(1):E4. doi: 10.3390/jof7010004. PMID: 33374839

Predicting Mortality after Autologous Transplant: Development of a Novel Risk Score. Berro M, Chhabra S, Pinana J, Arbelbide J, Rivas M, Basquiera A, Vitriu A, Requejo A, Milovic V, Yantorno S, Bentolila G, Garcia J, Castro M, Palmer S, Saslavsky M, Duarte P, Cerutti A, Jarchum G, Bana M, Thapa B, Solano C, Sureda A, Rovira M, Shaw B, Kusminsky G, Grp Argentino Trasplante Medula Os. Biology of Blood and Marrow Transplantation. 2020 Oct;26(10):1828-1832. doi: 10.1016/j.bbmt.2020.06.028. PMID: 32640312

Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation. Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte R, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socie G, Solano Vercet C, Vrhovac R, Zeiser R, Kroger N, Basak G. Lancet Haematology. 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485

Prospective Randomized Study Comparing Myeloablative Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Stem Cell Transplantation for Adults with Hematologic Malignancies. Sanz J, Montoro J, Solano Vercet C, Valcarcel D, Sampol A, Ferra C, Parody R, Lorenzo I, Montesinos P, Orti G, Hernandez Boluda J, Balaguer-Rosello A, Guerreiro M, Carretero C, Sanz G, Sanz M, Pinana J. Biology of Blood and Marrow. 2020 Feb;26(2):358-366. doi: 10.1016/j.bbmt.2019.10.014. PMID: 31655119

Rabbit ATG/ATLG in preventing graft-versus-host disease after allogeneic stem cell transplantation: consensus-based recommendations by an international expert panel. Bonifazi F, Rubio M, Bacigalupo A, Boelens J, Finke J, Greinix H, Mohty M, Nagler A, Passweg J, Rambaldi A, Socie G, Solano Vercet C, Walker I, Barosi G, Kroeger N. Bone Marrow Transplantation. 2020 Jun;55(6):1093-1102. doi: 10.1038/s41409-020-0792-x. PMID: 31969678

Reconstitution of cytomegalovirus-specific T-cell immunity following unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Remigia Pellicer M, Amat Martínez P, Vazquez Lopez L, Hernandez M, Hernandez Boluda J, Gago B, Piñana Sanchez J, Garcia M, Perez Martinez A, Mateo Jimenez E, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1347-1356. doi: 10.1038/s41409-020-0865-x. PMID: 32205853

Risk factors and outcome of COVID-19 in patients with hematological malignancies. Pinana J, Martino R, Garcia-Garcia I, Parody R, Morales M, Benzo G, Gomez-Catalan I, Coll R, De la Fuente I, Luna A, Merchan B, Chinea A, de Miguel D, Serrano A, Perez C, Diaz C, Lopez J, Saez A, Bailen R, Zudaire T, Martinez D, Jurado M, Calbacho M, Vazquez L, Garcia-Cadenas I, Fox L, Pimentel A, Bautista G, Nieto A, Fernandez P, Vallejo J, Solano C, Valero M, Espigado I, Saldana R, Sisinni L, Ribera J, Jimenez M, Trabazo M, Gonzalez-Vicent M, Fernandez N, Talarn C, Montoya M, Cedillo A, Sureda A, Spanish Hematopoietic Stem Cell Tr. Experimental Hematology & Oncology. 2020 Aug 25;9:21. doi: 10.1186/s40164-020-00177-z. PMID: 32864192

The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey. Pinana J, Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Gimenez Quiles E, Gomez M, Guerreiro M, Gonzalez-Barbera E, Carretero C, Salavert M, Balaguer-Rosello A, Sanz G, Hernandez Boluda J, Solano Vercet C, Sanz J, Navarro Ortega D. Bone Marrow Transplantation. 2020 Feb;55(2):431-440. doi: 10.1038/s41409-019-0698-7. PMID: 31551521

Uniform graft-versus-host disease prophylaxis with posttransplant cyclophosphamide, sirolimus, and mycophenolate mofetil following hematopoietic stem cell transplantation from haploidentical, matched sibling and unrelated donors. Montoro J, Pinana J, Hernandez Boluda J, Hernani Morales R, Lorenzo I, Perez Martinez A, Guerreiro M, Balaguer-Rosello A, Sanz G, Carretero C, Albert Vicent E, Navarro Ortega D, Sanz M, Solano Vercet C, Sanz J. Bone Marrow Transplantation. 2020 Nov;55(11):2147-2159. doi: 10.1038/s41409-020-0921-6. PMID: 32371901

Use of micafungin as antifungal prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Spain (GETH-MIC). Lopez-Sanchez C, Valcarcel D, Gomez V, Lopez-Jimenez J, Serrano D, Rubio V, Solano Vercet C, Vazquez L, Ruiz I, Grupo Espanol de Trasplante Hematopoyetico (GETH). Revista Espanola de Quimioterapia. 2020 Apr;33(2):110-115. doi: 10.37201/req/094.2019. PMID: 32056418

Proyectos
Referencia: PI21/01628
Título: Inmunobiología de células NK expandidas con criterios GMP de donantes seleccionados de banco de linfocitos para inmunoterapia adoptiva después de TPH alogénico o trasplante de órgano sólido
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Solano Vercet
Duración: 2022 – 2024
Presupuesto: 102.850 €
Referencia: BIO21/COV/030
Título: Estudio de la inmunidad y Creación de un Banco Nacional de Terapia Celular Adoptiva de donantes de linfocitos que han superado COVID-19. Ensayo clínico Fase I multicéntrico para evaluar la seguridad de la infusión de células natural killer como terapia adoptiva en casos pacientes con neumonía y/o linfopenia debido al coronavirus SARS-CoV-2 (RELEASE)
Entidad Financiadora: Fundación Vasca de Innovación e investigación Sanitarias (BIOEFF)
Investigador principal: Cristina Eguizabal
Duración: 2021 – 2022
Presupuesto: 99.935 €
Referencia: GV/2020/188
Título: Anellovirus y Pegivirus un posible marcador del estado neto de inmunosupresión: evaluación en el trasplante alogénico de progenitores hematopoyéticos
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Estela Giménez Quiles
Duración: 2020 – 2021
Presupuesto: 16.000 €
Referencia: AP178182020
Título: Estudio de la inmunidad y Creación de un Banco Nacional de Terapia Celular Adoptiva de donantes de linfocitos que han superado COVID-19. Ensayo clínico Fase I multicéntrico para evaluar la seguridad de la infusión de células natural killer como terapia adoptiva en casos pacientes con neumonía y/o linfopenia debido al coronavirus SARS-CoV-2 (RELEASE)
Entidad Financiadora: Fundación Mutua Madrileña
Investigador principal: Cristina Eguizabal
Duración: 2020 – 2021
Presupuesto: 100.000 €
Referencia: PI18/01473
Título: Inmunología de la infusión de linfocitos del donante con depleción ex vivo de linfocitos t cd45ra+ en pacientes con alto riesgo de infección viral tras TPH alogénico
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Solano Vercet
Duración: 2019 – 2023
Presupuesto: 123.420 €
Referencia: PI15/01396
Título: Inmunobiología de la aloreactividad NK en el trasplante de progenitores hematopoyéticos haploidenticos asociado al uso de ciclofosfamida post-trasplante
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carlos Solano Vercet
Duración: 2016 – 2019
Presupuesto: 116.765 €
+ Información
Título: Impacto de la alorreactividad NK en el trasplante haploidéntico de progenitores hematopoyéticos asociado al uso de la ciclofosfamida postrasplante
Doctorando: Luis Hidalgo, Mª Mar
Director: Solano Vercet, Carlos; Piñana Sánchez, Jose Luis; Planelles Silvestre, Dolores
Fecha: 21/12/2022
Universidad: Universitat de València

Título: Significado pronóstico de la expresión del factor de crecimiento endotelial vascular (VEGF) y de genes implicados en las vías de señalización del VEGF en pacientes con leucemia aguda mieloblástica
Doctorando: Calabuig Muñoz, Marisa
Director: Tormo Díaz, Mar; Solano Vercet, Carlos
Fecha: 04/05/2022
Universidad: Universitat de València

Título: Estudio de la enfermedad residual mínima en pacientes con mieloma múltiple en muy buena respuesta parcial o completa convencional mediante citometría de flujo de alta sensibilidad y la medición de cadenas mediante la técnica Hevylite
Doctorando: Remigia Pellicer, María José
Director: De la Rubia Comos, Javier; Sempere Talens, Amparo; Solano Vercet, Carlos
Fecha: 04/06/2021
Universidad: Universitat de València