Dr. Carlos Solano Vercet

Investigador Principal
Grupo de Investigación en Trasplante Hematopoyético

Presentación

Jefe del Servicio de Hematología y Hemoterapia y Director del Programa de Trasplante Hematopoyético y Terapia Celular del Hospital Clínico Universitario de Valencia. Catedrático de Medicina, Departamento de Medicina. Facultad de Medicina de la Universidad de Valencia.

Se licenció en Medicina y Cirugía por la Universidad de Valencia. Realizó la Residencia en Hematología y Hemoterapia en el Hospital Universitario La Princesa de Madrid. Después de dos estancias de investigación en el Hospital Hammersmith, Londres y el Medical Center de UCLA, Los Angeles-CA, en 1990 se incorporó como Médico Adjunto de Hematología del Hospital Clínico Universitario de Valencia. Obtuvo el doctorado en Medicina por la Universidad de Valencia en 1996, realizando investigación sobre la recuperación inmune después de trasplante hematopoyético.

Ha sido Presidente del Grupo Español de Trasplante Hematopoyético y Terapia Celular (GETH) y Coordinador de los Comités de Inmunoterapia/Enfermedad injerto contra receptor y de Normativa y Acreditación del GETH. Vicepresidente de la Comisión Nacional de la Especialidad de Hematología y Hemoterapia.

Es autor de más de 250 artículos originales en revistas de la especialidad, con especial interés en la investigación de la biología y tratamiento de la enfermedad injerto contra receptor y de las complicaciones infecciosas del paciente inmunodeprimido.

Investigador
Principal
Dr. Carlos Solano Vercet

carlos.solano@uv.es

Publicaciones
Allogeneic Hematopoietic Stem Cell Transplant recipients in Spain: Human Leucocyte Antigen characteristics and diversity by high-resolution analysis. Guerreiro M, Planelles D, Aguilar-Gallardo C, Lorenzo J, Montoro J, Sanz J, Balaguer A, Gomez I, Solves P, Perez A, Blanquer M, Espigado I, Solano C, Pinana J, Grupo Espanol de Trasplante Hematopoyetico y Terapia Celular (GETH). HLA. 2021 Mar;97(3):198-213. doi: 10.1111/tan.14179. PMID: 33369244

Amplification of human beta-glucoronidase gene for appraising the accuracy of negative SARS-CoV-2 RT-PCR results in upper respiratory tract specimens. Albert Vicent E, Ferrer Lores B, Torres Fink I, Serrano Alcalá A, Alcaráz Soriana M, Buesa Gomez J, Solano Vercet C, Colomina Rodríguez F, Bueno Ferrando F, Huntley Pascual D, Olea Miguel B, Valdivia Piqueres A, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):48-50. doi: 10.1002/jmv.26112. PMID: 32484950

An investigation of the potential association between gastrointestinal viral and bacterial infection and development of intestinal acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. Bueno F, Albert E, Gimenez E, Pinana J, Perez A, Gomez M, Hernandez-Boluda J, Gonzalez-Barbera E, Montoro J, Buesa J, Guerreiro M, Balaguer-Rosello A, Hernani R, Sanz J, Solano C, Navarro D. Journal of Medical Virology. 2021 Feb 19. doi: 10.1002/jmv.26892. PMID: 33605457

Assessment of the association between cytomegalovirus DNAemia and subsequent acute Graft-versus-Host Disease in allogeneic peripheral blood stem cell transplantation: a multicenter study from the Spanish Hematopoietic Transplantation and Cell Therapy Group. Bueno F, Solano C, Vazquez L, Gimenez E, de la Camara R, Albert E, Rovira M, Espigado I, Martin Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta AJ, Torrado T, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta MA, Duarte R, Pinana JL, Navarro D. Transplant Infectious Disease. 2021 Apr 28;e13627. doi: 10.1111/tid.13627. PMID: 33908148

Cytomegalovirus DNAemia and risk of mortality in allogeneic hematopoietic stem cell transplantation: Analysis from the Spanish Hematopoietic Transplantation and Cell Therapy Group. Solano Vercet C, Vazquez L, Gimenez Quiles E, De La Camara R, Albert Vicent E, Rovira M, Espigado I, Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez Martinez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Bautista G, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Pinana J, Navarro Ortega D. American Journal of Transplantation. 2021 Jan;21(1):258-271. doi: 10.1111/ajt.16147. PMID: 32812351

SARS-CoV-2-reactive interferon-gamma-producing CD8+ T cells in patients hospitalized with Coronavirus Disease 2019. Gimenez Quiles E, Albert Vicent E, Torres Fink I, Remigia Pellicer M, Alcaráz Soriana M, Galindo Puerto M, Blasco Cortes M, Solano Vercet C, Forner Giner M, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):375-382. doi: 10.1002/jmv.26213. PMID: 32579268

Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. Pinana J, Xhaard A, Tridello G, Passweg J, Kozijn A, Polverelli N, Heras I, Perez A, Sanz J, Berghuis D, Vazquez L, Suarez-Lledo M, Itala-Remes M, Ozcelik T, Iturrate Basaran I, Karakukcu M, Al Zahrani M, Choi G, Cuesta Casas M, Batlle Massana M, Viviana A, Blijlevens N, Ganser A, Kuskonmaz B, Labussiere-Wallet H, Shaw P, Arzu Yegin Z, Gonzalez-Vicent M, Rocha V, Ferster A, Knelange N, Navarro D, Mikulska M, de la Camara R, Styczynski J, Infectious Diseases Working Party of the European Society for Blood and, Marrow Transplantation and Infectious Complications Subcommittee of the, Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group, (GETH). The Journal of Infectious Diseases. 2021 May 20;223(9):1564-1575. doi: 10.1093/infdis/jiaa553. PMID: 32860509

Use of letermovir in off-label indications: Infectious Diseases Working Party of European Society of Blood and Marrow Transplantation retrospective study. Styczynski J, Tridello G, Xhaard A, Medinger M, Mielke S, Taskinen M, Blijlevens N, Rodriguez M, Solano C, Nikolousis E, Biffi A, Groll A, Junghanss C, Tsirigotis P, Lioure B, Sramek J, Holler E, Galaverna F, Fagioli F, Knelange N, Wendel L, Gil L, de la Camara R, Mikulska M, Ljungman P. Bone Marrow Transplantation. 2021 May;56(5):1171-1179. doi: 10.1038/s41409-020-01166-w. PMID: 33288863

An investigation of the utility of plasma Cytomegalovirus (CMV) microRNA detection to predict CMV DNAemia in allogeneic hematopoietic stem cell transplant recipients. Talaya Peñalver A, Gimenez Quiles E, Pascual M, Gago B, Piñana Sanchez J, Hernandez Boluda J, Vazquez L, Garcia M, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Medical Microbiology And Immunology. 2020 Feb;209(1):15-21. doi: 10.1007/s00430-019-00632-7. PMID: 31478067

Assessing the impact on intestinal microbiome and clinical outcomes of antibiotherapy optimisation strategies in haematopoietic stem cell transplant recipients: study protocol for the prospective multicentre OptimBioma study. Jimenez-Jorge S, Labrador-Herrera G, Rosso-Fernandez C, Rodriguez-Torres N, Pachon-Ibanez M, Smani Y, Marquez-Malaver F, Limon Ramos C, Solano Vercet C, Vazquez-Lopez L, Kwon M, Mora Barrios J, Aguilar-Guisado M, Espigado I, GETH (Grupo Espanol de Trasplante Hematopoyetico y Terapia Celular). BMJ Open. 2020 Jul 20;10(7):e034570. doi: 10.1136/bmjopen-2019-034570. PMID: 32690735

Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell transplantation. Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Hernandez Boluda J, Gimenez Quiles E, Gomez M, Balaguer-Rosello A, Gonzalez-Barbera E, Guerreiro M, Aguilar C, Navarro Ortega D, Solano Vercet C, Sanz J, Luis Pinana J. Transplant Infectious Disease. 2020 Aug;22(4):e13301. doi: 10.1111/tid.13301. PMID: 32363665

Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) (vol 55, pg 681, 2019). Snowden J, Saccardi R, Orchard K, Ljungman P, Duarte R, Labopin M, McGrath E, Brook N, de Elvira C, Gordon D, Poirel H, Ayuk F, Beguin Y, Bonifazi F, Gratwohl A, Milpied N, Moore J, Passweg J, Rizzo J, Spellman S, Sierra J, Solano Vercet C, Sanchez-Guijo F, Worel N, Gusi A, Adams G, Balan T, Baldomero H, Macq G, Marry E, Mesnil F, Oldani E, Pearce R, Perry J, Raus N, Schanz U, Tran S, Wilcox L, Basak G, Chabannon C, Corbacioglu S, Dolstra H, Kuball J, Mohty M, Lankester A, Montoto S, Nagler A, Styczynski J, Yakoub-Agha I, de Latour R, Kroeger N, Brand R, de Wreede L, van Zwet E, Putter H. Bone Marrow Transplantation. 2020 Apr;55(4):838-839. doi: 10.1038/s41409-019-0740-9. PMID: 31754251

Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Snowden J, Saccardi R, Orchard K, Ljungman P, Duarte R, Labopin M, McGrath E, Brook N, de Elvira C, Gordon D, Poirel H, Ayuk F, Beguin Y, Bonifazi F, Gratwohl A, Milpied N, Moore J, Passweg J, Rizzo J, Spellman S, Sierra J, Solano Vercet C, Sanchez-Guijo F, Worel N, Gusi A, Adams G, Balan T, Baldomero H, Macq G, Marry E, Mesnil F, Oldani E, Pearce R, Perry J, Raus N, Schanz U, Tran S, Wilcox L, Basak G, Chabannon C, Corbacioglu S, Dolstra H, Kuball J, Mohty M, Lankester A, Montoto S, Nagler A, Styczynski J, Yakoub-Agha I, de Latour R, Kroeger N, Brand R, de Wreede L, van Zwet E, Putter H. Bone Marrow Transplantation. 2020 Apr;55(4):681-694. doi: 10.1038/s41409-019-0718-7. PMID: 31636397

Clinical outcomes of allogeneic hematopoietic stem cell transplant recipients developing Cytomegalovirus DNAemia prior to engraftment. Solano C, Vazquez L, Gimenez E, de la Camara R, Albert E, Rovira M, Espigado I, Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Pinana J, Navarro D, Spanish Group of Hematopoietic Transplantation and Cell Therapy (GETH). Bone Marrow Transplantation. 2020 Dec 15. doi: 10.1038/s41409-020-01157-x. PMID: 33319853

Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens. Luis Pinana J, Albert Vicent E, Dolores Gomez M, Perez Martinez A, Hernandez Boluda J, Montoro J, Salavert M, Maria Gonzalez E, Tormo Diaz M, Gimenez Quiles E, Villalba M, Balaguer-Rosello A, Hernani Morales R, Bueno Ferrando F, Borras Salvador R, Sanz J, Solano Vercet C, Navarro Ortega D. The Journal of infection. 2020 May;80(5):578-606. doi: 10.1016/j.jinf.2020.01.001. PMID: 31926954

Cytomegalovirus DNA load monitoring in stool specimens for anticipating the occurrence of intestinal acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: Is it of any value?. Bueno Ferrando F, Albert Vicent E, Gimenez Quiles E, Pinana J, Perez Martinez A, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Aug 9;e13440. doi: 10.1111/tid.13440. PMID: 32772456

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2020 Nov 11. doi: 10.1002/jmv.26661. PMID: 33174620

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Network for Research in Infectious Diseases (REIPI) and the Spanish Society of Haematology and Haemotherapy (SEHH) on the management of febrile neutropenia in patients with hematological malignancies. Gudiol C, Aguilar-Guisado M, Azanza J, Candel F, Cantón R, Carratalà J, Garcia-Vidal C, Jarque I, Lizasoain M, Gil-Bermejo J, Ruiz-Camps I, Sánchez-Ortega I, Solano Vercet C, Suárez-Lledó M, Vázquez L, De La Cámara R. Enfermedades Infecciosas y Microbiologia Clinica. 2020 Apr;38(4):174-181. doi: 10.1016/j.eimc.2019.01.013. PMID: 30926172

Feasibility of thiotepa addition to the fludarabine-busulfan conditioning with tacrolimus/sirolimus as graft vs host disease prophylaxis. Fox M, Garcia-Cadenas I, Perez Martinez A, Villacampa G, Pinana J, Orti G, Montoro J, Roldan E, Bosch Vilaseca A, Martino R, Salamero O, Saavedra S, Hernandez Boluda J, Esquirol A, Sierra J, Sanz J, Solano Vercet C, Bosch F, Barba P, Valcarcel D. Leukemia & Lymphoma. 2020 Aug;61(8):1823-1832. doi: 10.1080/10428194.2020.1788015. PMID: 32654570

Features of Cytomegalovirus DNAemia Blips in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Implications for Optimization of Preemptive Antiviral Therapy Strategies. Huntley Pascual D, Talaya Peñalver A, Gimenez Quiles E, Perez Martinez A, Hernandez Boluda J, Hernani Morales R, Torres Fink I, Alberola J, Albert Vicent E, Piñana Sanchez J, Solano Vercet C, Navarro Ortega D. Biology of Blood and Marrow Transplantation. 2020 May;26(5):972-977. doi: 10.1016/j.bbmt.2020.01.015. PMID: 32007638

Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium. Sanchez-Maldonado J, Campa D, Springer J, Badiola J, Niazi Y, Moniz-Diez A, Hernandez-Mohedo F, Gonzalez-Sierra P, Ter Horst R, Macauda A, Brezina S, Cunha C, Lackner M, Lopez-Nevot M, Fianchi L, Pagano L, Lopez-Fernandez E, Potenza L, Luppi M, Moratalla L, Rodriguez-Sevilla J, Fonseca J, Tormo Diaz M, Solano Vercet C, Clavero E, Romero A, Li Y, Lass-Florl C, Einsele H, Vazquez L, Loeffler J, Hemminki K, Carvalho A, Netea M, Gsur A, Dumontet C, Canzian F, Forsti A, Jurado M, Sainz J. Blood Cancer Journal. 2020 Jul 16;10(7):75. doi: 10.1038/s41408-020-00341-y. PMID: 32678078

Impact of clinical features, cytogenetics, genetic mutations, and methylation dynamics of CDKN2B and DLC-1 promoters on treatment response to azacitidine. Martin Gonzalez I, Navarro Cubells B, Serrano Alcalá A, Villamón Ribate E, Calabuig Muñoz M, Solano Vercet C, Chaves Martínez F, Yague N, Orts M, Amat Martínez P, Fuentes Trillo A, Seda García E, García García F, Hernandez Boluda J, Tormo Diaz M. Annals of Hematology. 2020 Mar;99(3):527-537. doi: 10.1007/s00277-020-03932-8. PMID: 31989250

Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with post-transplantation cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Jesus Pascual M, Hernandez Boluda J, Gago B, Vazquez Lopez L, Luis Pinana J, Garcia M, Perez Martinez A, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Feb;22(1):e13206. doi: 10.1111/tid.13206. PMID: 31677215

Kinetics of Torque Teno virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation. Bueno Ferrando F, Albert Vicent E, Pinana J, Perez Martinez A, Ubeda C, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Gimenez Quiles E, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant infectious disease. 2020 Nov 11;e13507. doi: 10.1111/tid.13507. PMID: 33176050

Peripheral blood regulatory T cells and occurrence of Cytomegalovirus DNAemia after unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Vázquez L, Amat Martínez P, Remigia Pellicer M, Hernández M, Hernandez Boluda J, Gago B, Piñana Sanchez J, García M, Perez Martinez A, Alberola J, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1493-1496. doi: 10.1038/s41409-020-0950-1. PMID: 32447351

Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis. Lupianez C, Martinez-Bueno M, Sanchez-Maldonado J, Badiola J, Cunha C, Springer J, Lackner M, Segura-Catena J, Canet L, Alcazar-Fuoli L, Lopez-Nevot M, Fianchi L, Aguado J, Pagano L, Lopez-Fernandez E, Alarcon-Riquelme M, Potenza L, Goncalves S, Luppi M, Moratalla L, Solano Vercet C, Sampedro A, Gonzalez-Sierra P, Cuenca-Estrella M, Lagrou K, Maertens J, Lass-Floerl C, Einsele H, Vazquez L, Loeffler J, Rios-Tamayo R, Carvalho A, Jurado M, Sainz J. Infection and Immunity. 2020 Mar 23;88(4):e00882-19. doi: 10.1128/IAI.00882-19. PMID: 31964743

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium. Sanchez-Maldonado J, Moniz-Diez A, Ter Horst R, Campa D, Cabrera-Serrano A, Martinez-Bueno M, Garrido-Collado M, Hernandez-Mohedo F, Fernandez-Puerta L, Lopez-Nevot M, Cunha C, Gonzalez-Sierra P, Springer J, Lackner M, Alcazar-Fuoli L, Fianchi L, Aguado J, Pagano L, Lopez-Fernandez E, Clavero E, Potenza L, Luppi M, Moratalla L, Solano C, Sampedro A, Cuenca-Estrella M, Lass-Florl C, Pcraga Study Group, Canzian F, Loeffler J, Li Y, Einsele H, Netea M, Vazquez L, Carvalho A, Jurado M, Sainz J. Journal Of Fungi. 2020 Dec 23;7(1):E4. doi: 10.3390/jof7010004. PMID: 33374839

Predicting Mortality after Autologous Transplant: Development of a Novel Risk Score. Berro M, Chhabra S, Pinana J, Arbelbide J, Rivas M, Basquiera A, Vitriu A, Requejo A, Milovic V, Yantorno S, Bentolila G, Garcia J, Castro M, Palmer S, Saslavsky M, Duarte P, Cerutti A, Jarchum G, Bana M, Thapa B, Solano C, Sureda A, Rovira M, Shaw B, Kusminsky G, Grp Argentino Trasplante Medula Os. Biology of Blood and Marrow Transplantation. 2020 Oct;26(10):1828-1832. doi: 10.1016/j.bbmt.2020.06.028. PMID: 32640312

Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation. Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte R, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socie G, Solano Vercet C, Vrhovac R, Zeiser R, Kroger N, Basak G. Lancet Haematology. 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485

Prospective Randomized Study Comparing Myeloablative Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Stem Cell Transplantation for Adults with Hematologic Malignancies. Sanz J, Montoro J, Solano Vercet C, Valcarcel D, Sampol A, Ferra C, Parody R, Lorenzo I, Montesinos P, Orti G, Hernandez Boluda J, Balaguer-Rosello A, Guerreiro M, Carretero C, Sanz G, Sanz M, Pinana J. Biology of Blood and Marrow. 2020 Feb;26(2):358-366. doi: 10.1016/j.bbmt.2019.10.014. PMID: 31655119

Rabbit ATG/ATLG in preventing graft-versus-host disease after allogeneic stem cell transplantation: consensus-based recommendations by an international expert panel. Bonifazi F, Rubio M, Bacigalupo A, Boelens J, Finke J, Greinix H, Mohty M, Nagler A, Passweg J, Rambaldi A, Socie G, Solano Vercet C, Walker I, Barosi G, Kroeger N. Bone Marrow Transplantation. 2020 Jun;55(6):1093-1102. doi: 10.1038/s41409-020-0792-x. PMID: 31969678

Reconstitution of cytomegalovirus-specific T-cell immunity following unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Remigia Pellicer M, Amat Martínez P, Vazquez Lopez L, Hernandez M, Hernandez Boluda J, Gago B, Piñana Sanchez J, Garcia M, Perez Martinez A, Mateo Jimenez E, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1347-1356. doi: 10.1038/s41409-020-0865-x. PMID: 32205853

Risk factors and outcome of COVID-19 in patients with hematological malignancies. Pinana J, Martino R, Garcia-Garcia I, Parody R, Morales M, Benzo G, Gomez-Catalan I, Coll R, De la Fuente I, Luna A, Merchan B, Chinea A, de Miguel D, Serrano A, Perez C, Diaz C, Lopez J, Saez A, Bailen R, Zudaire T, Martinez D, Jurado M, Calbacho M, Vazquez L, Garcia-Cadenas I, Fox L, Pimentel A, Bautista G, Nieto A, Fernandez P, Vallejo J, Solano C, Valero M, Espigado I, Saldana R, Sisinni L, Ribera J, Jimenez M, Trabazo M, Gonzalez-Vicent M, Fernandez N, Talarn C, Montoya M, Cedillo A, Sureda A, Spanish Hematopoietic Stem Cell Tr. Experimental Hematology & Oncology. 2020 Aug 25;9:21. doi: 10.1186/s40164-020-00177-z. PMID: 32864192

The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey. Pinana J, Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Gimenez Quiles E, Gomez M, Guerreiro M, Gonzalez-Barbera E, Carretero C, Salavert M, Balaguer-Rosello A, Sanz G, Hernandez Boluda J, Solano Vercet C, Sanz J, Navarro Ortega D. Bone Marrow Transplantation. 2020 Feb;55(2):431-440. doi: 10.1038/s41409-019-0698-7. PMID: 31551521

Uniform graft-versus-host disease prophylaxis with posttransplant cyclophosphamide, sirolimus, and mycophenolate mofetil following hematopoietic stem cell transplantation from haploidentical, matched sibling and unrelated donors. Montoro J, Pinana J, Hernandez Boluda J, Hernani Morales R, Lorenzo I, Perez Martinez A, Guerreiro M, Balaguer-Rosello A, Sanz G, Carretero C, Albert Vicent E, Navarro Ortega D, Sanz M, Solano Vercet C, Sanz J. Bone Marrow Transplantation. 2020 Nov;55(11):2147-2159. doi: 10.1038/s41409-020-0921-6. PMID: 32371901

Use of micafungin as antifungal prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Spain (GETH-MIC). Lopez-Sanchez C, Valcarcel D, Gomez V, Lopez-Jimenez J, Serrano D, Rubio V, Solano Vercet C, Vazquez L, Ruiz I, Grupo Espanol de Trasplante Hematopoyetico (GETH). Revista Espanola de Quimioterapia. 2020 Apr;33(2):110-115. doi: 10.37201/req/094.2019. PMID: 32056418

Acute GVHD prophylaxis plus ATLG after myeloablative allogeneic haemopoietic peripheral blood stem-cell transplantation from HLA-identical siblings in patients with acute myeloid leukaemia in remission: final results of quality of life and long-term outcome analysis of a phase 3 randomised study. Bonifazi F, Solano C, Wolschke C, Sessa M, Patriarca F, Zallio F, Nagler A, Selleri C, Risitano AM, Messina G, Bethge W, Herrera P, Sureda A, Carella AM, Cimminiello M, Guidi S, Finke J, Sorasio R, Ferra C, Sierra J, Russo D, Benedetti E, Milone G, Benedetti F, Heinzelmann M, Pastore D, Jurado M, Terruzzi E, Narni F, Völp A, Ayuk F, Ruutu T, Kröger N. Lancet Haematology. 2019 Feb;6(2):e89-e99. doi: 10.1016/S2352-3026(18)30214-X. PMID: 30709437

Clinical effectiveness of influenza vaccination after allogeneic hematopoietic stem cell transplantation: A cross-sectional prospective observational study. Piñana JL, Pérez A, Montoro J, Giménez E, Gómez MD, Lorenzo I, Madrid S, González EM, Vinuesa V, Hernández-Boluda JC, Salavert M, Sanz G, Solano C, Sanz J, Navarro D. Clinical Infectious Diseases. 2019 May 17;68(11):1894-1903. doi: 10.1093/cid/ciy792. PMID: 30239624

Cytomegalovirus (CMV) infection and risk of mortality in allogeneic hematopoietic stem cell transplantation (Allo-SCT): A systematic review, meta-analysis and meta-regression analysis. Giménez E, Torres I, Albert E, Piñana JL, Hernández-Boluda JC, Solano C, Navarro D. American Journal of Transplantation. 2019 Sep;19(9):2479-2494. doi: 10.1111/ajt.15515. PMID: 31247126

Cytomegalovirus DNAemia in patients with de novo acute myeloid leukemia undergoing cytotoxic chemotherapy. Tormo M, Giménez E, Calabuig M, Talaya A, Navarro B, Amat P, Martín I, Albert E, Solano C, Navarro D. Leukemia & Lymphoma. 2019 Dec;60(12):3081-3083. doi: 10.1080/10428194.2019.1613541. PMID: 31111760

Cytomegalovirus-specific CD8+ T cell levels at viral DNAemia onset fail to predict the eventual need for preemptive antiviral therapy in allogeneic hematopoietic stem cell transplant recipients. Giménez E, Solano C, Piñana JL, Poch M, Mateo E, Albert E, Hernández-Boluda JC, Amat P, Remigia MJ, Pérez A, Navarro D. Journal of Infectious Diseases. 2019 Apr 16;219(9):1510-1512. doi: 10.1093/infdis/jiy746. PMID: 30597050

Donor lymphocyte infusions for B-cell malignancies relapse after T-cell replete allogeneic hematopoietic cell transplantation. Ortí G, García-Cadenas I, López-Corral L, Pérez A, Jimenez MJ, Sánchez-Ortega I, Alonso L, Sisinni L, Fox L, Villacampa G, Badell I, de Heredia CD, Parody R, Ferrà C, Solano C, Caballero D, Martino R, Querol S, Valcárcel D. Bone Marrow Transplantation. 2019 Jul;54(7):1133-1137. doi: 10.1038/s41409-018-0422-z. PMID: 30546069

Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation A Randomized Clinical Trial. Bastidas A, de la Serna J, El Idrissi M, Oostvogels L, Quittet P, López-Jiménez J, Vural F, Pohlreich D, Zuckerman T, Issa NC, Gaidano G, Lee JJ, Abhyankar S, Solano C, Perez de Oteyza J, Satlin MJ, Schwartz S, Campins M, Rocci A, Vallejo Llamas C, Lee DG, Tan SM, Johnston AM, Grigg A, Boeckh MJ, Campora L, Lopez-Fauqued M, Heineman TC, Stadtmauer EA, Sullivan KM; ZOE-HSCT Study Group Collaborators. JAMA-Journal of the American Medical Association. 2019 Jul 9;322(2):123-133. doi: 10.1001/jama.2019.9053. PMID: 31287523

Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. Guglieri-Lopez B, Perez-Pitarch A, Garcia-Cadenas I, Gimenez E, Barba P, Rabella N, Hernandez-Boluda JC, Fox L, Valcarcel D, Esquirol A, Ferriols-Lisart R, Sierra J, Solano C, Navarro D, Martino R, Piñana JL. Biology of Blood and Marrow Transplantation. 2019 May;25(5):1022-1030. doi: 10.1016/j.bbmt.2019.01.012. PMID: 30639821

Frequency, characteristics, and outcome of PTLD after allo-SCT: A multicenter study from the Spanish group of blood and marrow transplantation (GETH). García-Cadenas I, Yáñez L, Jarque I, Martino R, Pérez-Simón JA, Valcárcel D, Sanz J, Bermúdez A, Muñoz C, Calderón-Cabrera C, García E, Alonso L, Suárez-Lledó M, González Vicent M, Heras I, Viguria MC, Batlle M, Vázquez L, López J, Solano C; Spanish group of blood and marrow transplantation (GETH)15. European Journal of Haematology. 2019 Jun;102(6):465-471. doi: 10.1111/ejh.13226. PMID: 30828868

Haploidentical Stem Cell Transplantation With Posttransplant Cyclophosphamide Therapy vs Other Donor Transplantations in Adults With Hematologic Cancers: A Systematic Review and Meta-analysis. Gagelmann N, Bacigalupo A, Rambaldi A, Hoelzer D, Halter J, Sanz J, Bonifazi F, Meijer E, Itälä-Remes M, Marková M, Solano C, Kröger N. JAMA Oncology. 2019 Oct 17;5(12):1739-1748. doi: 10.1001/jamaoncol.2019.3541. PMID: 31621796

Incidence, risk factors, and outcome of pulmonary invasive fungal disease after respiratory virus infection in allogeneic hematopoietic stem cell transplantation recipients. Piñana JL, Gómez MD, Montoro J, Lorenzo I, Pérez A, Giménez E, González-Barberá EM, Carretero C, Guerreiro M, Salavert M, Sanz G, Hernández-Boluda JC, Borrás R, Sanz J, Solano C, Navarro D. Transplant infectious disease. 2019 Oct;21(5):e13158. doi: 10.1111/tid.13158. PMID: 31402532

Intravenous busulfan plus melphalan versus melphalan alone as conditioning regimen for patients with multiple mieloma. Blanes M, Lorenzo JI, Ribas P, Jiménez A, González JD, Cejalvo MJ, Solano C, Alegre A, de la Rubia J. Annals of Hematology. 2019 Aug;98(8):2013-2015. doi: 10.1007/s00277-019-03663-5. PMID: 30879095

Pharmacokinetic/pharmacodynamic analysis of voriconazole against Candida spp. and Aspergillus spp. in allogeneic stem cell transplant recipients. Perez-Pitarch A, Guglieri-Lopez B, Ferriols-Lisart R, Pérez A, Ezquer-Garín C, Hernández-Boluda JC, Piñana JL, Navarro D, Solano C, Alós-Almiñana M. Therapeutic Drug Monitoring. 2019 Dec;41(6):740-747. doi: 10.1097/FTD.0000000000000657. PMID: 31136417

Pre-engraftment cytomegalovirus DNAemia in allogeneic hematopoietic stem cell transplant recipients: incidence, risk factors, and clinical outcomes. Solano C, Giménez E, Albert E, Mateo EM, Gómez M, Goterris R, Pérez A, Amat P, Hernández-Boluda JC, Poch M, Piñana JL, Navarro D. Bone Marrow Transplantation. 2019 Jan;54(1):90-98. doi: 10.1038/s41409-018-0251-0. PMID: 29899574

Predictive factors of immune tolerance treatment response in severe haemophilia A patients with inhibitors: A real-world report from a single centre, mixed retrospective-prospective long-term study. Haya S, Solano C, Cid AR, Argilés B, Hervás D, Querol F, Bonanad S, Casaña P. Haemophilia. 2019 Mar;25(2):e97-e100. doi: 10.1111/hae.13660. PMID: 30604912

Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia. Piñana JL, Giménez E, Gómez MD, Pérez A, González EM, Vinuesa V, Hernández-Boluda JC, Montoro J, Salavert M, Tormo M, Amat P, Moles P, Carretero C, Balaguer-Roselló A, Sanz J, Sanz G, Solano C, Navarro D. Journal of Infection. 2019 May;78(5):393-401. doi: 10.1016/j.jinf.2019.02.009. PMID: 30797790

Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial. Mullane KM, Morrison VA, Camacho LH, Arvin A, McNeil SA, Durrand J, Campbell B, Su SC, Chan ISF, Parrino J, Kaplan SS, Popmihajlov Z, Annunziato PW; V212 Protocol 011 Trial Team. Lancet Infectious Diseases. 2019 Sep;19(9):1001-1012. doi: 10.1016/S1473-3099(19)30310-X. PMID: 31399378

Synergistic Antioncogenic Activity of Azacitidine and Curcumin in Myeloid Leukemia Cell Lines and Patient Samples. Martín I, Navarro B, Solano C, Calabuig M, Hernández-Boluda JC, Amat P, Remigia MJ, García F, Villamón E, Tormo M. Anticancer Research. 2019 Sep;39(9):4757-4766. doi: 10.21873/anticanres.13659. PMID: 31519576

Thrombopoietin Receptor Agonists for Severe Thrombocytopenia after Allogeneic Stem Cell Transplantation: Experience of the Spanish Group of Hematopoietic Stem Cell Transplant. Bento L, Bastida JM, García-Cadenas I, García-Torres E, Rivera D, Bosch-Vilaseca A, De Miguel C, Martínez-Muñoz ME, Fernández-Avilés F, Roldán E, Chinea A, Yáñez L, Zudaire T, Vaz CP, Espigado I, López J, Valcárcel D, Duarte R, Cabrera R, Herrera C, González-Porras JR, Gutiérrez A, Solano C, Sampol A; Grupo Español de Trasplante Hematopoyético (GETH). Biology of blood and marrow transplantation. 2019 Sep;25(9):1825-1831. doi: 10.1016/j.bbmt.2019.05.023. PMID: 31152794

Proyectos
Referencia: PI18/00127
Título: Virología e inmunología de la infección por el citomegalovirus (CMV) en el paciente con neoplasia hematológicas en la era de las nuevas bioterapias
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: David Navarro Ortega
Duración: 2019 – 2021
Presupuesto: 111.320 €

Referencia: PI18/01473
Título: Inmunología de la infusión de linfocitos del donante con depleción ex vivo de linfocitos t cd45ra+ en pacientes con alto riesgo de infección viral tras TPH alogénico
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: Carlos Solano Vercet
Duración: 2019 – 2021
Presupuesto: 123.420 €

Referencia: PI15/00090
Título: Inmunobiología de la infección por el citomegalovirus en el trasplante alogénico de precursores hematopoyéticos haploidéntico asociado al uso de ciclofosfamida postrasplante
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: David Navarro Ortega
Duración: 2016 – 2019
Presupuesto: 98.615 €

+ Información
Título: Torque teno virus como marcador subrogado de inmunocompetencia en el trasplante
Doctorando: Albert Vicent, Eliseo
Director: Navarro Ortega, David
Fecha: 13/02/2020
Universidad: Universitat de València

Título: Concentración mínima inhibitoria de vancomicina para staphylococcus aureus y riesgo de bacteriemia complicada
Doctorando: Falcón Abad, Rocío
Director: Navarro Ortega, David
Fecha: 02/10/2019
Universidad: Universitat de València