Grupo de Investigación en Psiquiatría y Enfermedades Neurodegenerativas

Área de Metabolismo y Daño Orgánico


Nuestro grupo tiene como objetivo entender mejor las alteraciones que se presentan en el cerebro de los pacientes para encontrar nuevas vías de diagnóstico y tratamiento. Para ello desarrollamos proyectos de investigación dirigidos a entender cómo cambia el sistema nervioso en los pacientes con enfermedad mental grave y la influencia que la carga genética y el ambiente, particularmente las experiencias adversas en la infancia/adolescencia, tienen sobre el desarrollo de estos trastornos psiquiátricos. Para lograr esto contamos con un amplio grupo de investigadores e investigadoras y de aproximaciones experimentales que abarcan la genética, la biología celular, la neuroimagen y la evaluación neuropsicológica.

Líneas principales:

– Estudio de la influencia de las experiencias adversas durante las primeras etapas de la vida en el desarrollo de trastornos mentales graves.
– Estudio de alteraciones estructurales y funcionales en el cerebro de pacientes con esquizofrenia crónica, en primeros episodios psicóticos y en depresión.
– Identificación de interacciones Gen-Ambiente en primeros episodios psicóticos.
– Desarrollo de nuevas técnicas para el diagnóstico de psicosis mediante MRI, expresión génica y machine learning.
– Desarrollo de modelos animales de trastorno mental grave y de respuesta farmacológica a estas enfermedades. Papel de las redes neuronales inhibidoras.
– Modelos de predicción de respuesta en primeros episodios psicóticos
– Identificación de factores de riesgo genéticos y biomarcadores de respuesta a medicación en esquizofrenia.
– Análisis de los factores de riesgo al suicidio en las personas con Trastorno Mental Grave.
– Identificación de genes modificadores, nuevas dianas y moléculas con potencial terapéutico en la ataxia de Friedreich.


Coordinador
Dr. Juan Nácher Roselló
juan.nacher@uv.es

INVESTIGADORES
R4 Senior

Juan Nácher Roselló    
Julio Sanjuán Arias

R3 Consolidado

Eduardo Jesús Aguilar García-Iturrospe
Mª Dolores Moltó Ruiz

R2 Novel / Emergente

Mª José Escartí Fabra
Olga María Rivero Martín    
Carlos Cañete Nicolás
Esther Lorente Rovira
Francisco Olucha Bordonau
Gracián García Martí
Héctor Carceller Cerdá
Jon Iñaki Etxeandia Pradera
José Carlos González Piqueras
Marien Gadea Domenech
Marta Pérez Rando
Miguel Hernández Viadel

R1 Predoctoral

Gabriel Daniel Flores Gómez
Javier David Lluesma
Julia Alcaide Pozo
Marc Beltrán Martínez
Patrycja Klimczak
Yaiza Gramuntell Roch

STAFF
Colaborador/a

Alba Postiguillo Giraldos

Enfermero/a
Técnico/a

Cristina Uzunova

Apoyo

Virginia Gómez Soriano

Publicaciones
Alterations in the volume and shape of the basal ganglia and thalamus in schizophrenia with auditory hallucinations. Perez-Rando M, Garcia-Marti G, Escarti M, Salgado-Pineda P, McKenna P, Pomarol-Clotet E, Grasa E, Postiguillo A, Corripio I, Nacher J. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2024 Apr 20:131:110960. doi: 10.1016/j.pnpbp.2024.110960. PMID: 38325744

Early chronic fasudil treatment rescues hippocampal alterations in the Ts65Dn model for down syndrome. Lopez-Hidalgo R, Ballestin R, Lorenzo L, Sanchez-Marti S, Blasco-Ibanez J, Crespo C, Nacher J, Varea E. Neurochemistry International. 2024 Feb 2:174:105679. doi: 10.1016/j.neuint.2024.105679. PMID: 38309665

Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms. Aranda S, Jimenez E, Canales-Rodriguez E, Verdolini N, Alonso S, Sepulveda E, Julia A, Marsal S, Bobes J, Saiz P, Garcia-Portilla P, Menchon J, Crespo J, Gonzalez-Pinto A, Perez V, Arango C, Sierra P, Sanjuan J, Pomarol-Clotet E, Vieta E, Vilella E. Molecular Psychiatry. 2024 Feb 19. doi: 10.1038/s41380-024-02480-1. PMID: 38374360

The influence of gender in cognitive insight and cognitive bias in people with first-episode psychosis: an uncontrolled exploratory analysis. Espinosa V, Naides N, López-Carrilero R, Vila-Badia R, Colomer-Salvans A, Barajas A, Barrigón M, Birulés I, Butjosa A, Díaz-Cutraro L, Del Cacho N, Frigola-Capell E, González-Higueras F, Grasa E, Gutiérrez-Zotes A, Lorente-Rovira E, Moreno-Kustner B, Pélaez T, Pousa E, Ruiz-Delgado I, Serra-Arumí C, Verdaguer-Rodríguez M, Grp Profep Spanish Metacognition Grp, Usall J, Ochoa S. Archives of Womens Mental Health. 2024 Feb 14. doi: 10.1007/s00737-024-01425-5. PMID: 38353751

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease. Llera-Oyola J, Carceller H, Andreu Z, Hidalgo M, Soler-Sáez I, Gordillo F, Gómez-Cabañes B, Roson B, de la Iglesia-vayá M, Mancuso R, Guerini F, Mizokami A, García-García F. Biology of Sex Differences. 2024 Jan 31;15(1):13. doi: 10.1186/s13293-024-00588-1. PMID: 38297404

Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study. D’Andrea G, Quattrone D, Malone K, Tripoli G, Trotta G, Spinazzola E, Gayer-Anderson C, Jongsma H, Sideli L, Stilo S, La Cascia C, Ferraro L, Lasalvia A, Tosato S, Tortelli A, Velthorst E, de Haan L, Llorca P, Menezes P, Santos J, Arrojo M, Bobes J, Sanjuán J, Bernardo M, Arango C, Kirkbride J, Jones P, Rutten B, Van Os J, Selten J, Vassos E, Schürhoff F, Szöke A, Pignon B, O’Donovan M, Richards A, Morgan C, Di Forti M, Tarricone I, Murray R. Psychological Medicine. 2024 Jan 30:1-14. doi: 10.1017/S0033291723003781. PMID: 38288603

A preliminary investigation of the clinical and cognitive correlates of circulating vitamin D in bipolar disorder. Van Rheenen T, Ringin E, Karantonis J, Furlong L, Bozaoglu K, Rossell S, Berk M, Balanza-Martinez V. Psychiatry Research. 2023 Feb;320:115013. doi: 10.1016/j.psychres.2022.115013. PMID: 36563627

Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study. Trotta G, Rodriguez V, Quattrone D, Spinazzola E, Tripoli G, Gayer-Anderson C, Freeman T, Jongsma H, Sideli L, Aas M, Stilo S, La Cascia C, Ferraro L, La Barbera D, Lasalvia A, Tosato S, Tarricone I, D’Andrea G, Tortelli A, Schürhoff F, Szöke A, Pignon B, Selten J, Velthorst E, de Haan L, Llorca P, Menezes P, Del Ben C, Santos J, Arrojo M, Bobes J, Sanjuán J, Bernardo M, Arango C, Kirkbride J, Jones P, Richards A, Rutten B, Van Os J, Austin-Zimmerman I, Li Z, Morgan C, Sham P, Vassos E, Wong C, Bentall R, Fisher H, Murray R, Alameda L, Di Forti M. Psychological Medicine. 2023 Nov;53(15):7375-7384. doi: 10.1017/S0033291723000995. PMID: 38078747

Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study. D’Andrea G, Lal J, Tosato S, Gayer-Anderson C, Jongsma H, Stilo S, van der Ven E, Quattrone D, Velthorst E, Berardi D, Menezes P, Arango C, Parellada M, Lasalvia A, La Cascia C, Ferraro L, La Barbera D, Sideli L, Bobes J, Bernardo M, Sanjuan J, Santos J, Arrojo M, Del-Ben C, Tripoli G, Llorca P, de Haan L, Selten J, Tortelli A, Szoke A, Muratori R, Rutten B, van Os J, Jones P, Kirkbride J, Murray R, di Forti M, Tarricone I, Morgan C. Psychological Medicine. 2023 Oct;53(13):6150-6160. doi: 10.1017/S003329172200335X. PMID: 36305570

Clustering schizophrenia genes by their temporal expression patterns aids functional interpretation. van der Meer D, Cheng W, Rokicki J, Fernandez-Cabello S, Shadrin A, Smeland O, Ehrhart F, Gülöksüz S, Pries L, Lin B, Rutten B, van Os J, O’Donovan M, Richards A, Steen N, Djurovic S, Westlye L, Andreassen O, Kaufmann T. Schizophrenia Bulletin. 2023 Oct 12:sbad140. doi: 10.1093/schbul/sbad140. PMID: 37824720

Cognition and social functioning in first episode psychosis: a systematic review of longitudinal studies. Montaner-Ferrer M, Gadea M, Sanjuan J. Frontiers in Psychiatry. 2023 Mar 6;14:1055012. doi: 10.3389/fpsyt.2023.1055012. PMID: 36950257

Common genetic variants contribute to heritability of age at onset of schizophrenia. Sada-Fuente E, Aranda S, Papiol S, Heilbronner U, Moltó MD, Aguilar EJ, González-Peñas J, Andreu-Bernabeu Á, Arango C, Crespo-Facorro B, González-Pinto A, Fañanás L, Arias B, Bobes J, Costas J, Martorell L, Schulze TG, Kalman JL, Vilella E, Muntané G. Translational Psychiatry. 2023 Jun 13;13(1):201. doi: 10.1038/s41398-023-02508-0. PMID: 37308478

Correction: Common genetic variants contribute to heritability of age at onset of schizophrenia. Sada-Fuente E, Aranda S, Papiol S, Heilbronner U, Moltó MD, Aguilar EJ, González-Peñas J, Andreu-Bernabeu Á, Arango C, Crespo-Facorro B, González-Pinto A, Fañanás L, Arias B, Bobes J, Costas J, Martorell L, Schulze TG, Kalman JL, Vilella E, Muntané G. Translational Psychiatry. 2023 Nov 30;13(1):369. doi: 10.1038/s41398-023-02651-8. PMID: 38036515

De la Serna E, Puig O, Mezquida G, Moreno-Izco L, Merchan-Naranjo J, Amoretti S, Ruiz P, Gonzalez-Pinto A, Molina-Garcia M, Corripio I, Vieta E, Baeza I, Berge D, Penades R, Sanchez-Torres A, Cuesta M, Bernardo M, Castro-Fornieles J, PEPs Group. Relationship between cognition and age at onset of first-episode psychosis: comparative study between adolescents, young adults, and adults. European Child & Adolescent Psychiatry. 2023 Apr;32(4):639-649. doi: 10.1007/s00787-021-01901-8. PMID: 34714406

Delirium-related psychiatric and neurocognitive impairment and the association with post-intensive care syndrome-A narrative review. Ramnarain D, Pouwels S, Fernandez-Gonzalo S, Navarra-Ventura G, Balanza-Martinez V. Acta Psychiatrica Scandinavica. 2023 May;147(5):460-474. doi: 10.1111/acps.13534. PMID: 36744298

Differences in patterns of stimulant use and their impact on first-episode psychosis incidence: an analysis of the EUGEI Study. Rodríguez-Toscano E, Alloza C, Fraguas D, Durán-Cutilla M, Roldán L, Sánchez-Gutiérrez T, López-Montoya G, Parellada M, Moreno C, Gayer-Anderson C, Jongsma H, Di Forti M, Quattrone D, Velthorst E, de Haan L, Selten J, Szöke A, Llorca P, Tortelli A, Bobes J, Bernardo M, Sanjuán J, Santos J, Arrojo M, Tarricone I, Berardi D, Ruggeri M, Lasalvia A, Ferraro L, La Cascia C, La Barbera D, Menezes P, Del-Ben C, Rutten B, van Os J, Jones P, Murray R, Kirkbride J, Morgan C, Díaz-Caneja C, Arango C. Schizophrenia Bulletin. 2023 Sep 7;49(5):1269-1280. doi: 10.1093/schbul/sbad013. PMID: 37467351

Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis. Costas-Carrera A, Verdolini N, Garcia-Rizo C, Mezquida G, Janssen J, Valli I, Corripio I, Sanchez-Torres A, Bioque M, Lobo A, Gonzalez-Pinto A, Rapado-Castro M, Vieta E, de la Serna H, Mane A, Roldan A, Crossley N, Penades R, Cuesta M, Parellada M, Bernardo M. Psychological Medicine. 2023 Nov 28:1-11. doi: 10.1017/S0033291723003185. PMID: 38014924

Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): recommendations from the GAGE-BD group. Lavin P, Rej S, Olagunju A, Teixeira A, Dols A, Alda M, Almeida O, Altinbas K, Balanza-Martinez V, Barbosa I, Blumberg H, Briggs F, Calkin C, Cassidy K, Forester B, Forlenza O, Hajek T, Haarman B, Jimenez E, Lafer B, Mulsant B, Oluwaniyi S, Patrick R, Radua J, Schouws S, Sekhon H, Simhandl C, Soares J, Tsai S, Vieta E, Villa L, Sajatovic M, Eyler L. Bipolar Disorders. 2023 Nov;25(7):554-563. doi: 10.1111/bdi.13312. PMID: 36843436

Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: results from the EUGEI study. Fusar-Poli L, Prachason T, Erzin G, Pries L, Brondino N, Politi P, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Escarti M, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O’Donovan M, van Os J, Rutten B, Guloksuz S. Psychiatry Research. 2023 May;323:115184. doi: 10.1016/j.psychres.2023.115184. PMID: 37015164

Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study. Alameda L, Liu Z, Sham P, Aas M, Trotta G, Rodriguez V, Di Forti M, Stilo S, Kandaswamy R, Arango C, Arrojo M, Bernardo M, Bobes J, de Haan L, Del-Ben C, Gayer-Anderson C, Sideli L, Jones P, Jongsma H, Kirkbride J, La Cascia C, Lasalvia A, Tosato S, Llorca P, Menezes P, van Os J, Quattrone D, Rutten B, Santos J, Sanjuan J, Selten J, Szoke A, Tarricone I, Tortelli A, Velthorst E, Morgan C, Dempster E, Hannon E, Burrage J, Dwir D, Arumuham A, Mill J, Murray R, Wong C. Molecular Psychiatry. 2023 May;28(5):2095-2106. doi: 10.1038/s41380-023-02044-9. PMID: 37062770

Fluoxetine increased adult neurogenesis is mediated by 5-HT3 receptor. Olivas-Cano I, Rodriguez-Andreu JM, Blasco-Ibanez JM, Crespo C, Nacher J, Varea E. Neuroscience Letters. 2023 Jan 31;795:137027. doi: 10.1016/j.neulet.2022.137027. PMID: 36566831

Invited commentary: suicidal ideation in first psychotic episodes. Aguilar E, Carrasco J. Schizophrenia Research. 2023 Aug 3;260:1-2. doi: 10.1016/j.schres.2023.07.025. PMID: 37543006

Lithium levels and lifestyle in patients with bipolar disorder: a new tool for self-management. Zorrilla I, Lopez-Zurbano S, Alberich S, Barbero I, Lopez-Pena P, Garcia-Corres E, Pascual J, Crespo J, de Dios C, Balanza-Martinez V, Gonzalez-Pinto A. International Journal of Bipolar Disorders. 2023 Mar 16;11(1):11. doi: 10.1186/s40345-023-00291-x. PMID: 36929031

Noncovalent peptide stapling using Alpha-Methyl-l-Phenylalanine for a-Helical Peptidomimetics. Bathgate R, Praveen P, Sethi A, Furuya W, Dhingra R, Kocan M, Ou Q, Valkovic A, Gil-Miravet I, Navarro-Sánchez M, Olucha-Bordonau F, Gundlach A, Rosengren K, Gooley P, Dutschmann M, Hossain M. Journal of the American Chemical Society. 2023 Sep 20;145(37):20242-20247. doi: 10.1021/jacs.3c02743. PMID: 37439676

Obstetric complications and genetic risk for schizophrenia: differential role of antenatal and perinatal events in first episode psychosis. Valli I, Segura A, Verdolini N, Garcia Rizo C, Berge D, Baeza I, Cuesta M, Gonzalez Pinto A, Lobo A, Martinez Aran A, Mezquida G, Pina Camacho L, Bejarano A, Mas S, McGuire P, Bernardo M, Vieta E, Amoretti S, Aina A, Balanza Martinez V, Borras R, Butjosa A, Castro Fornirles J, De la Camara C, De la Serna E, Etxeandia Pradera J, Forte M, Garcia Portilla P, Gonzalez J, Gonzalez Blanco L, Gonzalez Ortega I, Ibanez A, Madero S, Martinez Sadurni L, Nacher J, Panadero R, Edith P, Fatjo Vilas M, Rodriguez Jimenez R, Ruiz P, Sanchez Pastor L, Rafael S, Sanchez Torres A, Judith S, Trabsa A, Urbiola E, Usall J, Arantzazu Z, Zorrilla I. Acta Psychiatrica Scandinavica. 2023 Jul;148(1):81-90. doi: 10.1111/acps.13546. PMID: 36912272

Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?. Baeza I, de la Serna E, Mezquida G, Cuesta M, Vieta E, Amoretti S, Lobo A, Gonzalez-Pinto A, Diaz-Caneja C, Corripio I, Valli I, Puig O, Mane A, Bioque M, Ayora M, Bernardo M, Castro-Fornieles J, Balanza Martinez V, PEPs Grp. European Child & Adolescent Psychiatry. 2023 Apr 7. doi: 10.1007/s00787-023-02196-7. PMID: 37027026

Progressive loss of cortical gray matter in first episode psychosis patients with auditory hallucinations. Garcia-Marti G, Escarti MJ, Nacher J, Perez-Rando M, Mane A, Usall J, Berrocoso E, Pomarol-Clotet E, Lopez-Ilundain JM, Cuesta MJ, Rodriguez-Jimenez R, Gonzalez-Pinto A, Mar L, Ibañez A, Roldan A, Janssen J, Parellada M, Amoretti S, Bernardo M, Sanjuan J, Aguilar EJ. Schizophrenia Research. 2023 Dec 2:S0920-9964(23)00423-1. doi: 10.1016/j.schres.2023.11.011. PMID: 38044223

Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy. Gonzalez-Penas J, de Hoyos L, Diaz-Caneja C, Andreu-Bernabeu A, Stella C, Gurriaran X, Fananas L, Bobes J, Gonzalez-Pinto A, Crespo-Facorro B, Martorell L, Vilella E, Muntane G, Molto M, Gonzalez-Piqueras J, Parellada M, Arango C, Costas J. Scientific Reports. 2023 Sep 19;13(1):15500. doi: 10.1038/s41598-023-42578-0. PMID: 37726359

Relationship between cognition and suicidal behavior in recent-onset psychosis. Sastre-Buades A, Caro-Canizares I, Ochoa S, Lorente-Rovira E, Barajas A, Gutierrez-Zotes A, Sanchez-Alonso S, Lopez-Carrilero R, Grasa E, Pousa E, Pelaez T, Cid J, Gonzalez-Higueras F, Ruiz-Delgado I, Baca-Garcia E, Barrigon M. Schizophrenia Research. 2023 Jan 16;252:172-180. doi: 10.1016/j.schres.2022.12.042. PMID: 36652834

Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Liu D, Meyer D, Fennessy B, Feng C, Cheng E, Johnson JS, Park YJ, Rieder MK, Ascolillo S, de Pins A, Dobbyn A, Lebovitch D, Moya E, Nguyen TH, Wilkins L, Hassan A, Burdick KE, Buxbaum JD, Domenici E, Frangou S, Hartmann AM, Laurent-Levinson C, Malhotra D, Pato CN, Pato MT, Ressler K, Roussos P, Rujescu D, Arango C, Bertolino A, Blasi G, Bocchio-Chiavetto L, Campion D, Carr V, Fullerton JM, Gennarelli M, González-Peñas J, Levinson DF, Mowry B, Nimgaokar VL, Pergola G, Rampino A, Cervilla JA, Rivera M, Schwab SG, Wildenauer DB, Daly M, Neale B, Singh T, O’Donovan MC, Owen MJ, Walters JT, Ayub M, Malhotra AK, Lencz T, Sullivan PF, Sklar P, Stahl EA, Huckins LM, Charney AW. Nature Genetics. 2023 Mar;55(3):369-376. doi: 10.1038/s41588-023-01305-1. PMID: 36914870

Spanish adaptation and validation of the ALS Depression Inventory-12 (ADI-12) in patients with Amyotrophic Lateral Sclerosis. Sancho-Cantus D, Cubero-Plazas L, Privado J, Garcia-Iturrospe E, Canabate Ros M, Navarro-Illana E, Orti J. Archives of Medical Research. 2023 Dec 22;55(1):102936. doi: 10.1016/j.arcmed.2023.102936. PMID: 38141272

Structural covariance predictors of clinical improvement at 2-year follow-up in first-episode psychosis. Saiz-Masvidal C, Contreras F, Soriano-Mas C, Mezquida G, Diaz-Caneja C, Vieta E, Amoretti S, Lobo A, Gonzalez-Pinto A, Janssen J, Sague-Vilavella M, Castro-Fornieles J, Berge D, Bioque M, Lois N, Parellada M, Bernardo M, PEPs Group. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2023 Jan 10;120:110645. doi: 10.1016/j.pnpbp.2022.110645. PMID: 36181960

Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study. Aas M, Alameda L, Di Forti M, Quattrone D, Dazzan P, Trotta A, Ferraro L, Rodriguez V, Vassos E, Sham P, Tripoli G, La Cascia C, La Barbera D, Tarricone I, Muratori R, Berardi D, Lasalvia A, Tosato S, Szoke A, Llorca P, Arango C, Tortelli A, de Haan L, Velthorst E, Bobes J, Bernardo M, Sanjuan J, Santos J, Arrojo M, Del-Ben C, Menezes P, Selten J, Jones P, Jongsma H, Kirkbride J, Rutten B, van Os J, Gayer-Anderson C, Murray R, Morgan C. Psychological Medicine. 2023 Apr;53(5):1970-1978. doi: 10.1017/S0033291721003664. PMID: 37310339

T-cadherin is a novel regulator of pericyte function during angiogenesis. Dasen B, Pigeot S, Born G, Verrier S, Rivero O, Dittrich P, Martin I, Filippova M. American Journal of Physiology-Cell Physiology. 2023 Apr 1;324(4):C821-C836. doi: 10.1152/ajpcell.00326.2022. PMID: 36802732

The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case-control study. Spinazzola E, Quattrone D, Rodriguez V, Trotta G, Alameda L, Tripoli G, Gayer-Anderson C, Freeman T, Johnson E, Jongsma H, Stilo S, La Cascia C, Ferraro L, La Barbera D, Lasalvia A, Tosato S, Tarricone I, D’Andrea G, Galatolo M, Tortelli A, Tagliabue I, Turco M, Pompili M, Selten J, de Haan L, Menezes P, Del Ben C, Santos J, Arrojo M, Bobes J, Sanjuan J, Bernardo M, Arango C, Kirkbride J, Jones P, O’Donovan M, Rutten B, Van Os J, Morgan C, Sham P, Austin-Zimmerman I, Li Z, Vassos E, Murray R, Di Forti M. Psychological Medicine. 2023 Nov;53(15):7418-7427. doi: 10.1017/S0033291723001071. PMID: 37129249

The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats. Casquero-Veiga M, Lamanna-Rama N, Romero-Miguel D, Rojas-Marquez H, Alcaide J, Beltran M, Nacher J, Desco M, Soto-Montenegro M. Frontiers in Behavioral Neuroscience. 2023 Jan 6;16:1022622. doi: 10.3389/fnbeh.2022.1022622. PMID: 36733452

The polygenic basis of relapse after a first episode of schizophrenia. Segura A, Prohens L, Gasso P, Rodriguez N, Garcia-Rizo C, Moreno-Izco L, Andreu-Bernabeu A, Zorrilla I, Mane A, Rodriguez-Jimenez R, Roldan A, Sarro S, Ibanez A, Usall J, Saiz P, Cuesta M, Parellada M, Gonzalez-Pinto A, Berrocoso E, Bernardo M, Mas S, Mezquida G, Arbelo N, De Matteis M, Galvan J, Duque Guerra A, Arias I Queralt L, Perez-Bacigalupe M, Gonzalez-Ortega I, Toll A, Casanovas F, Sanchez-Pastor L, Valtuena M, Pomarol-Clotet E, Garcia-Leon M, Butjosa A, Rubio-Abadal E, Ribeiro M, Lopez-Ilundain J, Saiz-Ruiz J, Leon-Quismondo L, Rivero O, Ruiz P, Echevarria R, Garcia-Portilla M. European Neuropsychopharmacology. 2023 Aug 19;75:80-92. doi: 10.1016/j.euroneuro.2023.06.003. PMID: 37603902

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study. Sideli L, Aas M, Quattrone D, La Barbera D, La Cascia C, Ferraro L, Alameda L, Velthorst E, Trotta G, Tripoli G, Schimmenti A, Fontana A, Gayer-Anderson C, Stilo S, Seminerio F, Sartorio C, Marrazzo G, Lasalvia A, Tosato S, Tarricone I, Berardi D, D’Andrea G, Arango C, Arrojo M, Bernardo M, Bobes J, Sanjuan J, Santos J, Menezes P, Del-Ben C, Jongsma H, Jones P, Kirkbride J, Llorca P, Tortelli A, Pignon B, de Haan L, Selten J, Van Os J, Rutten B, Bentall R, Di Forti M, Murray R, Morgan C, Fisher H. Social Psychiatry and Psychiatric Epidemiology. 2023 Oct;58(10):1573-1580. doi: 10.1007/s00127-023-02513-0. PMID: 37335320

Tobacco use in first-episode psychosis, a multinational EU-GEI study. Sanchez-Gutierrez T, Rodriguez-Toscano E, Roldan L, Ferraro L, Parellada M, Calvo A, Lopez G, Rapado-Castro M, La Barbera D, La Cascia C, Tripoli G, Di Forti M, Murray R, Quattrone D, Morgan C, van Os J, Garcia-Portilla P, Al-Halabi S, Bobes J, de Haan L, Bernardo M, Santos J, Sanjuan J, Arrojo M, Ferchiou A, Szoke A, Rutten B, Stilo S, D’Andrea G, Tarricone I, Diaz-Caneja C, Arango C. Psychological Medicine. 2023 Nov;53(15):7265-7276. doi: 10.1017/S0033291723000806. PMID: 37185055

A polygenic approach to the association between smoking and schizophrenia. Al-Soufi L, Martorell L, Molto MD, Gonzalez-Penas J, Garcia-Portilla MP, Arrojo M, Rivero O, Gutierrez-Zotes A, Nacher J, Muntane G, Paz E, Paramo M, Bobes J, Arango C, Sanjuan J, Vilella E, Costas J. Addiction Biology. 2022 Jan;27(1):e13104. doi: 10.1111/adb.13104. PMID: 34779080

A replication study of JTC bias, genetic liability for psychosis and delusional ideation. Henquet C, van Os J, Pries L, Rauschenberg C, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan Arias J, Aguilar Garcia Iturrospe E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O’Donovan M, Rutten B, Guloksuz S. Psychological Medicine. 2022 Jul;52(9):1777-1783. doi: 10.1017/S0033291720003578. PMID: 33046166

Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations. Perez-Rando M, Elvira U, Garcia-Marti G, Gadea M, Aguilar E, Escarti M, Ahullo-Fuster M, Grasa E, Corripio I, Sanjuan J, Nacher J. NeuroImage Clinical. 2022 Jun 1;35:103070. doi: 10.1016/j.nicl.2022.103070. PMID: 35667173

Altered expression of vesicular glutamate transporter-2 and cleaved caspase-3 in the locus coeruleus of nerve-injured rats. Bravo L, Mariscal P, Llorca-Torralba M, Lopez-Cepero J, Nacher J, Berrocoso E. Frontiers in Molecular Neuroscience. 2022 Jul 27;15:918321. doi: 10.3389/fnmol.2022.918321. PMID: 35966012

Author Correction: Persons with first episode psychosis have distinct profiles of social cognition and metacognition. Ferrer-Quintero M, Fernandez D, Lopez-Carrilero R, Birules I, Barajas A, Lorente-Rovira E, Diaz-Cutraro L, Verdaguer M, Garcia-Mieres H, Sevilla-Llewellyn-Jones J, Gutierrez-Zotes A, Grasa E, Pousa E, Huerta-Ramos E, Pelaez T, Barrigon M, Gonzalez-Higueras F, Ruiz-Delgado I, Cid J, Moritz S, Ochoa S, Spanish Metacognition Grp. NPJ schizophrenia. 2022 Feb 24;8(1):3. doi: 10.1038/s41537-021-00199-4. PMID: 35210466

Brain activity changes with emotional words in different stages of psychosis. Soldevila-Matias P, Garcia-Marti G, Fuentes-Dura I, Ruiz JC, Gonzalez-Navarro L, Gonzalez-Vivas C, Radua J, Sanjuan J. European Psychiatry. 2022 Oct 4;66(1):e25. doi: 10.1192/j.eurpsy.2022.2321. PMID: 36193735

Childhood maltreatment, educational attainment, and IQ: findings from a Multicentric Case-control Study of First-episode Psychosis (EU-GEI). Sideli L, Schimmenti A, La Barbera D, La Cascia C, Ferraro L, Aas M, Alameda L, Velthorst E, Fisher H, Caretti V, Trotta G, Tripoli G, Quattrone D, Gayer-Anderson C, Seminerio F, Sartorio C, Marrazzo G, Lasalvia A, Tosato S, Tarricone I, Berardi D, D’Andrea G, Arango C, Arrojo M, Bernardo M, Bobes J, Sanjuan J, Santos J, Menezes P, Del-Ben C, Jongsma H, Jones P, Kirkbride J, Llorca P, Tortelli A, Pignon B, de Haan L, Selten J, Van Os J, Rutten B, Di Forti M, Morgan C, Murray R, EU-GEI WP2 Group. Schizophrenia Bulletin. 2022 May 7;48(3):575-589. doi: 10.1093/schbul/sbac004. PMID: 35137235

Cortical thinning over two years after first-episode psychosis depends on age of onset. Pina-Camacho L, Martinez K, Diaz-Caneja C, Mezquida G, Cuesta M, Moreno C, Amoretti S, Gonzalez-Pinto A, Arango C, Vieta E, Castro-Fornieles J, Lobo A, Fraguas D, Bernardo M, Janssen J, Parellada M, PEPs Group. NPJ Schizophrenia. 2022 Mar 11;8(1):20. doi: 10.1038/s41537-021-00196-7. PMID: 35277520

Different brain phenotypes in magnetic resonance imaging of healthy children after prenatal insults. Paules C, Roche M, Marin M, Fayed N, Garcia-Marti G, Pison J, Oros D, Pueyo V. Diagnostics. 2022 Nov 10;12(11):2748. doi: 10.3390/diagnostics12112748. PMID: 36359591

Different measures for auditory hallucinations in populations with psychosis. The Validation of the Spanish versions of the Auditory Vocal Hallucination Rating Scale (AVHRS) and the Positive and Useful Voices Inquiry (PUVI). Lorente-Rovira E, Grasa E, Ochoa S, Corripio I, Pelaez T, Lopez-Carrilero R, Gutierrez-Gea A, Morano-Guillen M, Villagran J, Bartels-Velthuis A, Jenner J, Sanjuan J. Revista de Psiquiatria y Salud Mental. 2022 Oct-Dec;15(4):259-271. doi: 10.1016/j.rpsmen.2020.03.002. PMID: 36513402

Editorial: Neurotrophins and their importance on neural plasticity: new insights and potential therapeutic effects on brain pathology. Perez-Rando M, Castillo-Gomez E. Frontiers in Molecular Neuroscience. 2022 Nov 15;15:1082116. doi: 10.3389/fnmol.2022.1082116. PMID: 36458197

Editorial: perineuronal nets as therapeutic targets for the treatment of neuropsychiatric disorders. Browne C, Conant K, Lasek A, Nacher J. Frontiers in Synaptic Neuroscience. 2022 Jun 10;14:889800. doi: 10.3389/fnsyn.2022.889800. PMID: 35782789

Estradiol regulates PSA-NCAM expression and connectivity of O-LM interneurons in the hippocampus of adult female mice. Perez-Rando M, Guirado R, Tellez-Merlo G, Carceller H, Nacher J. Neuroendocrinology. 2022;112(1):51-67. doi: 10.1159/000515052. PMID: 33550289

EUROLD: preliminary results of the ecological study on suicide and its associated socioeconomic variables in people over 85 in Europe. Rodriguez Ruzafa M, Carrasco Picazo JP, Junquera Fernandez G, Aguilar Garcia-Iturrospe EJ. International Psychogeriatrics. 2022 Feb 28;1-3. doi: 10.1017/S1041610222000072. PMID: 35225213

Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. van Os J, Pries L, Ten Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan Arias J, Aguilar Garcia Iturrospe E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O’Donovan M, Rutten B, Guloksuz S. Psychological Medicine. 2022 Jul;52(10):1910-1922. doi: 10.1017/S0033291720003748. PMID: 33070791

Examining facial emotion recognition as an intermediate phenotype for psychosis: findings from the EUGEI study. Fusar-Poli L, Pries L, van Os J, Erzin G, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Aguglia E, Arango C, O’Donovan M, Rutten B, Guloksuz S, Genetic Risk Outcome Psychosis Grp. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2022 Mar 8;113:110440. doi: 10.1016/j.pnpbp.2021.110440. PMID: 34536513

Facial emotion recognition in psychosis and associations with polygenic risk for schizophrenia: findings from the multi-center EU-GEI case-control study. Tripoli G, Quattrone D, Ferraro L, Gayer-Anderson C, La Cascia C, La Barbera D, Sartorio C, Seminerio F, Rodriguez V, Tarricone I, Berardi D, Jamain S, Arango C, Tortelli A, Llorca P, de Haan L, Velthorst E, Bobes J, Bernardo M, Sanjuan J, Santos J, Arrojo M, Del-Ben C, Menezes P, van der Ven E, Jones P, Jongsma H, Kirkbride J, Tosato S, Lasalvia A, Richards A, O’Donovan M, Rutten B, van Os J, Morgan C, Sham P, Di Forti M, Murray R, Murray G. Schizophrenia Bulletin. 2022 Sep 1;48(5):1104-1114. doi: 10.1093/schbul/sbac022. PMID: 35325253

Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study. Pignon B, Peyre H, Ayrolles A, Kirkbride JB, Jamain S, Ferchiou A, Richard JR, Baudin G, Tosato S, Jongsma H, de Haan L, Tarricone I, Bernardo M, Velthorst E, Braca M, Arango C, Arrojo M, Bobes J, Del-Ben CM, Di Forti M, Gayer-Anderson C, Jones PB, La Cascia C, Lasalvia A, Menezes PR, Quattrone D, Sanjuan J, Selten JP, Tortelli A, Llorca PM, van Os J, Rutten BPF, Murray RM, Morgan C, Leboyer M, Szoke A, Schurhoff F. Epidemiology and Psychiatric Sciences. 2022 Sep 27;31:e68. doi: 10.1017/S2045796022000464. PMID: 36165168

Heterogeneity in response to MCT and psychoeducation: a feasibility study using latent class mixed models in first-episode psychosis. Ferrer-Quintero M, Fernandez D, Lopez-Carrilero R, Diaz-Cutraro L, Verdaguer-Rodriguez M, Garcia-Mieres H, Huerta-Ramos E, Gomez-Benito J, Pelaez T, Birules I, Barajas A, Pousa E, Barrigon M, Gutierrez-Zotes A, Grasa E, Ruiz-Delgado I, Lorente-Rovira E, Cid J, Ochoa S. Healthcare. 2022 Oct 28;10(11):2155. doi: 10.3390/healthcare10112155. PMID: 36360496

How to Improve Training in Descriptive Psychopathology for Psychiatry Residents: A Delphi Study. Etxeandia-Pradera J, Landeta J, Gonzalez-Such J, Aguilar E. Psychopathology. 2022 Jul 29;1-14. doi: 10.1159/000525691. PMID: 35908537

How voices change the brain. Two fMRI follow-up case reports. Gonzalez-Vivas C, Valdes-Florido MJ, Garcia-Marti G, Soldevila-Matias P, Marti-Bonmati L, Nacher J, Sanjuan J. Schizophrenia Research. 2022 Oct;248:329-330. doi: 10.1016/j.schres.2022.09.016. PMID: 36155306

Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen. Perez-Rando M, Carceller H, Castillo-Gomez E, Bueno-Fernandez C, Garcia-Mompo C, Gilabert-Juan J, Guirado R, Pesarico A, Nacher J. Neurobiology of Stress. 2022 May 13;19:100460. doi: 10.1016/j.ynstr.2022.100460. PMID: 35734023

Impaired recollection and initially preserved familiarity in a patient with bilateral fornix transection following third ventricle colloid cyst removal: A two-year follow-up study. Fuentes M, Sales A, Charquero-Ballester M, Garcia-Marti G, Melendez J, Espert R, Scheel M, Bauknecht H, Simon K, Kopstein U, Gebauer S, Algarabel S. Applied Neuropsychology-Adult. 2022 Aug 2;1-13. doi: 10.1080/23279095.2022.2104162. PMID: 35917584

Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: differences between males and females. Serra-Navarro M, Amoretti S, Verdolini N, Forte M, Sanchez-Torres A, Vieta E, Clougher D, Lobo A, Gonzalez-Pinto A, Panadero R, Roldan A, Carvalho A, de la Serna E, Toll A, Ramos-Quiroga J, Torrent C, Cuesta M, Bernardo M, PEPs Group. Frontiers in Psychiatry. 2022 Oct 20;13:982583. doi: 10.3389/fpsyt.2022.982583. PMID: 36339856

Is metacognitive training effective for improving neurocognitive function in patients with a recent onset of psychosis?. Ruiz-Delgado I, Moreno-Kuestner B, Garcia-Medina M, Barrigon M, Gonzalez-Higueras F, Lopez-Carrilero R, Barrios-Mellado I, Barajas A, Pousa E, Lorente-Rovira E, Grasa E, Cid J, Barrau-Sastre P, Moritz S, Ochoa S, Spanish Metacognition Group. Psychiatry Research. 2022 Dec;318:114941. doi: 10.1016/j.psychres.2022.114941. PMID: 36375331

Is the effect of cognitive reserve in longitudinal outcomes in first-episode psychoses dependent on the use of cannabis?. Amoretti S, Verdolini N, Varo C, Mezquida G, Sanchez-Torres A, Vieta E, Garcia-Rizo C, Lobo A, Gonzalez-Pinto A, Abregu-Crespo R, Corripio I, Serra M, de la Serna E, Mane A, Ramos-Quiroga J, Ribases M, Cuesta M, Bernardo M. Journal of Affective Disorders. 2022 Apr 1;302:83-93. doi: 10.1016/j.jad.2022.01.077. PMID: 35066012

Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode. Segura A, Mezquida G, Martinez-Pinteno A, Gasso P, Rodriguez N, Moreno-Izco L, Amoretti S, Bioque M, Lobo A, Gonzalez-Pinto A, Garcia-Alcon A, Roldan-Bejarano A, Vieta E, de la Serna E, Toll A, Cuesta M, Mas S, Bernardo M. Psychological Medicine. 2022 Jun 9:1-14. doi: 10.1017/S0033291722001544. PMID: 35678455

Long term effects of 24-h-restraint stress on the connectivity and structure of interneurons in the basolateral amygdala. Pesarico A, Carceller H, Guirado R, Coviello S, Nacher J. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2022 Apr 20;115:110512. doi: 10.1016/j.pnpbp.2022.110512. PMID: 35066055

Males and females with first episode psychosis present distinct profiles of social cognition and metacognition. Ferrer-Quintero M, Fernandez D, Lopez-Carrilero R, Birules I, Barajas A, Lorente-Rovira E, Luengo A, Diaz-Cutraro L, Verdaguer M, Garcia-Mieres H, Gutierrez-Zotes A, Grasa E, Pousa E, Huerta-Ramos E, Pelaez T, Barrigon M, Gomez-Benito J, Gonzalez-Higueras F, Ruiz-Delgado I, Cid J, Moritz S, Sevilla-Llewellyn-Jones J, Ochoa S. European Archives of Psychiatry and Clinical Neuroscience. 2022 Oct;272(7):1169-1181. doi: 10.1007/s00406-022-01438-0. PMID: 35802165

Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Trubetskoy V, Pardinas A, Qi T, Panagiotaropoulou G, Indonesia Schizophrenia Consortium, PsychENCODE, Psychosis Endophenotypes International Consortium, SynGO Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature. 2022 Apr;604(7906):502-508. doi: 10.1038/s41586-022-04434-5. PMID: 35396580

Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort. Segura A, Martinez-Pinteno A, Gasso P, Rodriguez N, Bioque M, Cuesta M, Gonzalez-Penas J, Garcia-Rizo C, Lobo A, Gonzalez-Pinto A, Garcia-Alcon A, Roldan A, Vista E, Castro-Fornieles J, Mane A, Saiz J, Bernardo M, Mas S. Schizophrenia Research. 2022 Jun;244:101-110. doi: 10.1016/j.schres.2022.05.021. PMID: 35659654

Neutrophil to lymphocyte ratio in patients with a first episode of psychosis: a two-year longitudinal follow-up study. Bioque M, Matias-Martins A, Llorca-Bofi V, Mezquida G, Cuesta M, Vieta E, Amoretti S, Lobo A, Gonzalez-Pinto A, Moreno C, Roldan A, Martinez-Aran A, Baeza I, Berge D, Garcia-Rizo C, Herrero S, Bernardo M, 2EPs GROUP. Schizophrenia Bulletin. 2022 Nov 18;48(6):1327-1335. doi: 10.1093/schbul/sbac089. PMID: 35876785

Perineuronal nets: subtle structures with large implications. Carceller H, Gramuntell Y, Klimczak P, Nacher J. Neuroscientist. 2022 Jul 23;10738584221106346. doi: 10.1177/10738584221106346. PMID: 35872660

Phenotype and distribution of immature neurons in the human cerebral cortex layer II. Coviello S, Gramuntell Y, Klimczak P, Varea E, Blasco-Ibanez J, Crespo C, Gutierrez A, Nacher J. Frontiers in Neuroanatomy. 2022 Apr 8;16:851432. doi: 10.3389/fnana.2022.851432. PMID: 35464133

Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. Andreu-Bernabeu Á, Díaz-Caneja CM, Costas J, De Hoyos L, Stella C, Gurriarán X, Alloza C, Fañanás L, Bobes J, González-Pinto A, Crespo-Facorro B, Martorell L, Vilella E, Muntané G, Nacher J, Molto MD, Aguilar EJ, Parellada M, Arango C, González-Peñas J. Nature Communications. 2022 Jan 10;13(1):51. doi: 10.1038/s41467-021-27598-6. PMID: 35013163

Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies. Soldevila-Matías P, Albajes-Eizagirre A, Radua J, García-Martí G, Rubio JM, Tordesillas-Gutierrez D, Fuentes-Durá I, Solanes A, Fortea L, Oliver D, Sanjuán J. Revista de Psiquiatria y Salud Mental. 2022 Apr-Jun;15(2):101-116. doi: 10.1016/j.rpsmen.2022.06.004. PMID: 35840277

Prenatal development of the human entorhinal cortex. Simic G, Krsnik Z, Knezovic V, Kelovic Z, Mathiasen M, Junakovic A, Rados M, Mulc D, Spanic E, Quattrocolo G, Hall V, Zaborszky L, Vuksic M, Bordonau F, Kostovic I, Witter M, Hof P. Journal of Comparative Neurology. 2022 Oct;530(15):2711-2748. doi: 10.1002/cne.25344. PMID: 35603771

Relapse of first-episode schizophrenia patients and neurocognitive impairment: the role of dopaminergic and anticholinergic burden. Cuesta MJ, Ballesteros A, Sanchez-Torres AM, Amoretti S, Lopez-Ilundain JM, Merchan-Naranjo J, Gonzalez-Ortega I, Salgado P, Rodriguez-Jimenez R, Roldan-Bejarano A, Sarro S, Ibanez A, Usall J, Escarti MJ, Moreno-Izco L, Mezquida G, Parellada M, Gonzalez-Pinto A, Berrocoso E, Bernardo M. Schizophrenia Research. 2022 Oct;248:331-340. doi: 10.1016/j.schres.2022.09.014. PMID: 36155307

Relaxin ligand/receptor systems in the developing teleost fish brain: conserved features with mammals and a platform to address neuropeptide system functions. Blasiak A, Gugula A, Gundlach A, Olucha-Bordonau F, Aniello F, Donizetti A. Frontiers in Molecular Neuroscience. 2022 Oct 5;15:984524. doi: 10.3389/fnmol.2022.984524. PMID: 36277494

The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. Fusar-Poli L, Pries LK, van Os J, Radhakrishnan R, Pence AY, Erzin G, Delespaul P, Kenis G, Luykx JJ, Lin BD, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran ES, Kaymak SU, Mihaljevic MM, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz PA, Garcia-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric NP, Atbasoglu C, Ucok A, Alptekin K, Saka MC, Aguglia E, Arango C, Rutten BP, Guloksuz S. European Neuropsychopharmacology. 2022 Aug 30;63:47-59. doi: 10.1016/j.euroneuro.2022.08.003. PMID: 36055075

The effect of early life events on glucose levels in first-episode psychosis. Garcia-Rizo C, Cabrera B, Bioque M, Mezquida G, Lobo A, Gonzalez-Pinto A, Diaz-Caneja C, Corripio I, Vieta E, Baeza I, Garcia-Portilla M, Gutierrez-Fraile M, Rodriguez-Jimenez R, Garriga M, Fernandez-Egea E, Bernardo M. Frontiers in Endocrinology. 2022 Dec 5;13:983792. doi: 10.3389/fendo.2022.983792. PMID: 36545332

The incidence of psychotic disorders among migrants and minority ethnic groups in Europe: findings from the multinational EU-GEI study. Termorshuizen F, van der Ven E, Tarricone I, Jongsma H, Gayer-Anderson C, Lasalvia A, Tosato S, Quattrone D, La Cascia C, Szoke A, Berardi D, Llorca P, de Haan L, Velthorst E, Bernardo M, Sanjuan Arias J, Arrojo M, Murray R, Rutten B, Jones P, van Os J, Kirkbride J, Morgan C, Selten J. Psychological Medicine. 2022 May;52(7):1376-1385. doi: 10.1017/S0033291720003219. PMID: 32958094

The influence of modifiable cardiovascular risk factors on cognition, functioning, and inflammatory markers in first-episode psychosis: Results from a 2-year follow-up study. Pujol N, Berge D, Mane A, Bioque M, Mezquida G, Amoretti S, Baeza I, Gonzalez-Pinto A, Lobo A, Cuesta M, Ribeiro M, Sanchez-Tomico G, Perez-Sola V, Verdolini N, Vieta E, Parellada M, Roldan A, Bernardo M. Psychiatry Research. 2022 Oct;316:114760. doi: 10.1016/j.psychres.2022.114760. PMID: 35977447

The network structure of cognitive deficits in first episode psychosis patients. Sanchez-Torres A, Peralta V, Gil-Berrozpe G, Mezquida G, Ribeiro M, Molina-Garcia M, Amoretti S, Lobo A, Gonzalez-Pinto A, Merchan-Naranjo J, Corripio I, Vieta E, de la Serna E, Berge D, Bernardo M, Cuesta M, Aguilar Garcia Iturrospe E, PEPs Group, PEPs Group. Schizophrenia Research. 2022 Jun;244:46-54. doi: 10.1016/j.schres.2022.05.005. PMID: 35594732

The parietal lobe in Alzheimer’s disease and blindness. Ahullo-Fuster MA, Ortiz T, Varela-Donoso E, Nacher J, Sanchez-Sanchez ML. Journal of Alzheimer’s Disease. 2022;89(4):1193-1202. doi: 10.3233/JAD-220498. PMID: 36093700

The role of BDNF and NGF plasma levels in first-episode schizophrenia: a longitudinal study. Martinez Pinteno A, Mezquida G, Bioque M, Lopez Ilundain JM, Andreu Bernabeu A, Zorrilla I, Mane A, Rodriguez Jimenez R, Corripio I, Sarro S, Ibanez A, Usall J, Rivero O, Gasso P, Leza JC, Cuesta MJ, Parellada M, Gonzalez Pinto A, Berrocoso E, Mas S, Bernardo M. European Neuropsychopharmacology. 2022 Feb 23;57:105-117. doi: 10.1016/j.euroneuro.2022.02.003. PMID: 35219096

When the front fails, the rear wins. Cerebellar correlates of prefrontal dysfunction in cocaine-induced memory in male rats. Guarque-Chabrera J, Gil-Miravet I, Olucha-Bordonau F, Melchor-Eixea I, Miquel M. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2022 Jan 10;112:110429. doi: 10.1016/j.pnpbp.2021.110429. PMID: 34416354

A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood. Gasso P, Rodriguez N, Martinez-Pinteno A, Mezquida G, Ribeiro M, Gonzalez-Penas J, Zorrilla I, Martinez-Sadurni L, Rodriguez-Jimenez R, Corripio I, Sarro S, Ibanez A, Usall J, Lobo A, Moren C, Cuesta M, Parellada M, Gonzalez-Pinto A, Berrocoso E, Bernardo M, Mas S, 2EPs Grp. Translational Psychiatry. 2021 Oct 19;11(1):539. doi: 10.1038/s41398-021-01645-8. PMID: 34667144

A multicentre, randomised, controlled trial of a combined clinical treatment for first-episode psychosis. Gonzalez-Ortega I, Vega P, Echeburua E, Alberich S, Fernandez-Sevillano J, Barbeito S, Balanza-Martinez V, Vieta E, Lorente-Rovira E, Luengo A, Cerrillo E, Crespo J, Matute C, Gonzalez-Pinto A. International Journal of Environmental Research and Public Health. 2021 Jul 6;18(14):7239. doi: 10.3390/ijerph18147239. PMID: 34299697

Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Fernandez Garcia-Agudo L, Steixner-Kumar AA, Curto Y, Barnkothe N, Hassouna I, Jahne S, Butt UJ, Grewe K, Weber MS, Green K, Rizzoli S, Nacher J, Nave KA, Ehrenreich H. Cell Reports. 2021 Aug 24;36(8):109548. doi: 10.1016/j.celrep.2021.109548. PMID: 34433021

Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings. Velthorst E, Mollon J, Murray R, de Haan L, Germeys I, Glahn D, Arango C, van der Ven E, Di Forti M, Bernardo M, Guloksuz S, Delespaul P, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Santos J, Jimenez-Lopez E, Sanjuan J, Aguilar E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Atbasoglu C, Saka M, Ucok A, Alptekin K, Akdede B, Binbay T, Altinyazar V, Ulas H, Yalincetin B, Gumus-AkaY G, Beyaz B, Soygur H, Cankurtaran E, Kaymak S, Maric N, Mihaljevic M, Petrovic S, Mirjanic T, Del-Ben C, Ferraro L, Gayer-Anderson C, Jones P, Jongsma H, Kirkbride J, La Cascia C, Lasalvia A, Tosato S, Llorca P, Menezes P, Morgan C, Quattrone D, Menchetti M, Selten J, Szoke A, Tarricone I, Tortelli A, McGuire P, Valmaggia L, Kempton M, van der Gaag M, Riecher-Rossler A, Bressan R, Barrantes-Vidal N, Nelson B, McGorry P, Pantelis C, Krebs M, Ruhrmann S, Sachs G, Rutten B, van Os J, Alizadeh B, van Amelsvoort T, Bartels-Velthuis A, Bruggeman R, van Beveren N, Luykx J, Cahn W, Simons C, Kahn R, Schirmbeck F, van Winkel R, Reichenberg A, EU-GEI High Risk Study. Molecular Psychiatry. 2021 Aug;26(8):4529-4543. doi: 10.1038/s41380-020-00969-z. PMID: 33414498

COVID-19 lockdown influence in the psychiatric emergencies: Drastic reduction and increase in severe mental disorders. Carrasco JP, Herraiz B, Sanchez LO, Luengo A, Fusalba OR, Aguilar EJ. Revista de Psiquiatria y Salud Mental. 2021;14(2):117-118. doi: 10.1016/j.rpsm.2020.11.003. PMID: 33248289

Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results from the multi-center EU-GEI Study. Ajnakina O, Rodriguez V, Quattrone D, di Forti M, Vassos E, Arango C, Berardi D, Bernardo M, Bobes J, de Haan L, Del-Ben CM, Gayer-Anderson C, Jongsma HE, Lasalvia A, Tosato S, Llorca PM, Menezes PR, Rutten BP, Santos JL, Sanjuan J, Selten JP, Szoke A, Tarricone I, D’Andrea G, Richards A, Tortelli A, Velthorst E, Jones PB, Arrojo Romero M, La Cascia C, Kirkbride JB, van Os J, O’Donovan M, Murray RM. Schizophrenia Bulletin. 2021 Oct 21;47(6):1653-1662. doi: 10.1093/schbul/sbab055. PMID: 33963865

Editorial: Animal models of stress – current knowledge and potential directions. Pesarico A, Chagas P, Nacher J. Frontiers in Behavioral Neuroscience. 2021 Feb 16;15:655214. doi: 10.3389/fnbeh.2021.655214. PMID: 33664658

Effects of aging on the structure and expression of NMDA receptors of somatostatin expressing neurons in the mouse hippocampus. Gramuntell Y, Klimczak P, Coviello S, Perez-Rando M, Nacher J. Frontiers in Aging Neuroscience. 2021 Dec 23;13:782737. doi: 10.3389/fnagi.2021.782737. PMID: 35002680

Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: results from the EUGEI study. Erzin G, Pries L, van Os J, Fusar-Poli L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O’Donovan M, Rutten B, Guloksuz S, Genetic Risk and Outcome of Psychosis (GROUP) investigators. European psychiatry. 2021 Mar 19;64(1):e25. doi: 10.1192/j.eurpsy.2021.19. PMID: 33736735

Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity. Casquero-Veiga M, Bueno-Fernandez C, Romero-Miguel D, Lamanna-Rama N, Nacher J, Desco M, Soto-Montenegro M. Scientific Reports. 2021 Mar 10;11(1):5580. doi: 10.1038/s41598-021-82987-7. PMID: 33692388

FOXP2 expression and gray matter density in the male brains of patients with schizophrenia. Sanjuan Arias J, Castro-Martinez X, Garcia Marti G, Gonzalez-Fernandez J, Sanz-Requena R, Haro J, Meana J, Marti-Bonmati L, Nacher Roselló J, Sebastia Ortega N, Gilabert Juan J, Moltó Ruiz M. Brain Imaging and Behavior. 2021 Jun;15(3):1403-1411. doi: 10.1007/s11682-020-00339-x. PMID: 32734433

From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine-related cues. Gil-Miravet I, Melchor-Eixea I, Arias-Sandoval E, Vasquez-Celaya L, Guarque-Chabrera J, Olucha Bordonau F, Miquel M. Addiction Biology. 2021 Jan;26(1):e12834. doi: 10.1111/adb.12834. PMID: 31808992

Grey matter microstructural alterations in schizophrenia patients with treatment-resistant auditory verbal hallucinations. Sampedro F, Roldan A, Alonso-Solis A, Grasa E, Portella MJ, Aguilar EJ, Nunez-Marin F, Gomez-Anson B, Corripio I. Journal of Psychiatric Research. 2021 Jun;138:130-138. doi: 10.1016/j.jpsychires.2021.03.037. PMID: 33852993

Induced dipoles and possible modulation of wireless effects in implanted electrodes. effects of implanting insulated electrodes on an animal test to screen antidepressant activity. Perez-Caballero L, Carceller H, Nacher J, Teruel-Marti V, Pujades E, Casan-Pastor N, Berrocoso E. Journal of Clinical Medicine. 2021 Sep 4;10(17):4003. doi: 10.3390/jcm10174003. PMID: 34501451

Involvement of the nucleus incertus and relaxin-3/RXFP3 signaling system in explicit and implicit memory. Gil-Miravet I, Manas-Ojeda A, Ros-Bernal F, Castillo-Gomez E, Albert-Gasco H, Gundlach A, Olucha-Bordonau F. Frontiers in Neuroanatomy. 2021 Mar 18;15:637922. doi: 10.3389/fnana.2021.637922. PMID: 33867946

Jumping to conclusions and suicidal behavior in depression and psychosis. Sastre-Buades A, Ochoa S, Lorente-Rovira E, Barajas A, Grasa E, Lopez-Carrilero R, Luengo A, Ruiz-Delgado I, Cid J, Gonzalez-Higueras F, Sanchez-Alonso S, Baca-Garcia E, Barrigon M, Spanish Metacognition Study Grp. Journal of Psychiatric Research. 2021 May;137:514-520. doi: 10.1016/j.jpsychires.2021.03.024. PMID: 33812324

Jumping to conclusions, general intelligence, and psychosis liability: findings from the multi-centre EU-GEI case-control study.. Tripoli G, Quattrone D, Ferraro L, Gayer-Anderson C, Rodriguez V, La Cascia C, La Barbera D, Sartorio C, Seminerio F, Tarricone I, Berardi D, Szoke A, Arango C, Tortelli A, Llorca P, de Haan L, Velthorst E, Bobes J, Bernardo M, Sanjuan Arias J, Santos J, Arrojo M, Del-Ben C, Menezes P, Selten J, Jones P, Jongsma H, Kirkbride J, Lasalvia A, Tosato S, Richards A, O’Donovan M, Rutten B, Os J, Morgan C, Sham P, Murray R, Murray G, Di Forti M, EU-GEI WP2 Group. Psychological Medicine. 2021 Mar;51(4):623-633. doi: 10.1017/S003329171900357X. PMID: 32327005

Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice. Bueno-Fernandez C, Perez-Rando M, Alcaide J, Coviello S, Sandi C, Castillo-Gomez E, Nacher J. Neurobiology of Stress. 2021 Apr 1;14:100322. doi: 10.1016/j.ynstr.2021.100322. PMID: 33869684

Migration history and risk of psychosis: results from the multinational EU-GEI study. Tarricone I, D’Andrea G, Jongsma H, Tosato S, Gayer-Anderson C, Stilo S, Suprani F, Iyegbe C, van der Ven E, Quattrone D, di Forti M, Velthorst E, Rossi Menezes P, Arango C, Parellada M, Lasalvia A, La Cascia C, Ferraro L, Bobes J, Bernardo M, Sanjuan I, Santos J, Arrojo M, Del-Ben C, Tripoli G, Llorca P, de Haan L, Selten J, Tortelli A, Szoke A, Muratori R, Rutten B, van Os J, Jones P, Kirkbride J, Berardi D, Murray R, Morgan C. Psychological Medicine. 2021 Feb 10;1-13. doi: 10.1017/S003329172000495X. PMID: 33563347

Moderators of cognitive insight outcome in metacognitive training for first-episode psychosis. Gonzalez-Blanch C, Birules I, Pousa E, Barrigon M, Lopez-Carrilero R, Lorente-Rovira E, Ayesa-Arriola R, Setien-Suero E, Barajas A, Grasa E, Ruiz-Delgado I, Gonzalez-Higueras F, Cid J, Ochoa S. Journal of Psychiatric Research. 2021 Sep;141:104-110. doi: 10.1016/j.jpsychires.2021.06.040. PMID: 34186271

Motor abnormalities and basal ganglia in first-episode psychosis (FEP). Cuesta M, Lecumberri P, Moreno-Izco L, Lopez-Ilundain J, Ribeiro M, Cabada T, Lorente-Omenaca R, de Erausquin G, Garcia Marti G, Sanjuan Arias J, Sanchez-Torres A, Gomez M, Peralta V. Psychological Medicine. 2021 Jul;51(10):1625-1636. doi: 10.1017/S0033291720000343. PMID: 32114994

Neuroimaging correlates of insight in non-affective psychosis: a systematic review and meta-analysis. Soldevila-Matias P, Schoretsanitis G, Tordesillas-Gutierrez D, Cuesta M, de Filippis R, Ayesa-Arriola R, Gonzalez-Vivas C, Setien-Suero E, Verdolini N, Sanjuan J, Radua J, Crespo-Facorro B. Revista de Psiquiatria y Salud Mental. 2021 Jul 13:S1888-9891(21)00067-7. doi: 10.1016/j.rpsm.2021.07.001. PMID: 34271162

No Effects of Acute Psychosocial Stress on Working Memory in Older People With Type 2 Diabetes. Vallejo L, Zapater-Fajari M, Montoliu T, Puig-Perez S, Nacher J, Hidalgo V, Salvador A. Frontiers in Psychology. 2021 Jan 7;11:596584. doi: 10.3389/fpsyg.2020.596584. PMID: 33584433

Parvalbumin interneurons and perineuronal nets in the hippocampus and retrosplenial cortex of adult male mice after early social isolation stress and perinatal NMDA receptor antagonist treatment. Klimczak P, Rizzo A, Castillo-Gomez E, Perez-Rando M, Gramuntell Y, Beltran M, Nacher J. Frontiers in Synaptic Neuroscience. 2021 Sep 22;13:733989. doi: 10.3389/fnsyn.2021.733989. PMID: 34630066

Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study. Misra S, Gelaye B, Williams D, Koenen K, Borba C, Quattrone D, Di Forti M, Tripoli G, La Cascia C, La Barbera D, Ferraro L, Tarricone I, Berardi D, Lasalvia A, Tosato S, Szoke A, Llorca P, Arango C, Tortelli A, de Haan L, Velthorst E, Bobes J, Bernardo M, Sanjuan J, Santos J, Arrojo M, Del-Ben C, Menezes P, Selten J, Jones P, Jongsma H, Kirkbride J, Rutten B, van Os J, Murray R, Gayer-Anderson C, Morgan C. Psychological Medicine. 2021 Mar 2;1-9. doi: 10.1017/S0033291721000453. PMID: 33648622

Persons with first episode psychosis have distinct profiles of social cognition and metacognition. Ferrer-Quintero M, Fernandez D, Lopez-Carrilero R, Birules I, Barajas A, Lorente-Rovira E, Diaz-Cutraro L, Verdaguer M, Garcia-Mieres H, Sevilla-Llewellyn-Jones J, Gutierrez-Zotes A, Grasa E, Pousa E, Huerta-Ramos E, Pelaez T, Barrigon ML, Gonzalez-Higueras F, Ruiz-Delgado I, Cid J, Moritz S, Ochoa S. NPJ Schizophrenia. 2021 Dec 9;7(1):61. doi: 10.1038/s41537-021-00187-8. PMID: 34887442

Pre-training inter-rater reliability of clinical instruments in an international psychosis research Project. Berendsen S, Kapitein P, Schirmbeck F, van Tricht M, McGuire P, Morgan C, Gayer-Anderson C, Kempton M, Valmaggia L, Quattrone D, di Forti M, van der Gaag M, Kirkbride J, Jongsma H, Jones P, Parellada M, Arango C, Arrojo M, Bernardo M, Sanjuan Arias J, Santos J, Szoke A, Tortelli A, Llorca P, Tarricone I, Tripoli G, Ferraro L, La Cascia C, Lasalvia A, Tosato S, Menezes P, Del-Ben C, Nelson B, Riecher-Rossler A, Bressan R, Barrantes-Vidal N, Krebs M, Nordentoft M, Ruhrmann S, Sachs G, Rutten B, van Os J, Velthorst E, de Haan L, EU-GEI High Risk Study. Schizophrenia Research. 2021 Apr;230:104-107. doi: 10.1016/j.schres.2020.08.001. PMID: 33243716

PSA Depletion Induces the Differentiation of Immature Neurons in the Piriform Cortex of Adult Mice. Coviello S, Benedetti B, Jakubecova D, Belles M, Klimczak P, Gramuntell Y, Couillard-Despres S, Nacher J. International journal of molecular sciences. 2021 May 27;22(11):5733. doi: 10.3390/ijms22115733. PMID: 34072166

Rabphilin silencing causes dilated cardiomyopathy in a Drosophila model of nephrocyte damage. Selma-Soriano E, Casillas-Serra C, Artero R, Llamusi B, Navarro J, Redon J. Scientific Reports. 2021 Jul 27;11(1):15287. doi: 10.1038/s41598-021-94710-7. PMID: 34315987

Relaxin-3 innervation from the nucleus incertus to the parahippocampal cortex of the rat. Garcia-Diaz C, Gil-Miravet I, Albert-Gasco H, Manas-Ojeda A, Ros-Bernal F, Castillo-Gomez E, Gundlach A, Olucha-Bordonau F. Frontiers in Neuroanatomy. 2021 Jun 22;15:674649. doi: 10.3389/fnana.2021.674649. PMID: 34239421

ReMindCare, an app for daily clinical practice in patients with first episode psychosis: A pragmatic real-world study protocol. Bonet Mora L, Torous J, Arce D, Blanquer I, Sanjuan Arias J. Early Intervention In Psychiatry. 2021 Feb;15(1):183-192. doi: 10.1111/eip.12960. PMID: 32253830

Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis: results from the EU-GEI case-control study. Jongsma H, Gayer-Anderson C, Tarricone I, Velthorst E, van der Ven E, Quattrone D, di Forti M, Menezes P, Del-Ben C, Arango C, Lasalvia A, Berardi D, La Cascia C, Bobes J, Bernardo M, Sanjuan Arias J, Santos J, Arrojo M, de Haan L, Tortelli A, Szoke A, Murray R, Rutten B, van Os J, Morgan C, Jones P, Kirkbride J, EU-GEI WP2 Group. Psychological Medicine. 2021 Jul;51(9):1536-1548. doi: 10.1017/S003329172000029X. PMID: 32122439

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study. Quattrone D, Reininghaus U, Richards A, Tripoli G, Ferraro L, Quattrone A, Marino P, Rodriguez V, Spinazzola E, Gayer-Anderson C, Jongsma H, Jones P, La Cascia C, La Barbera D, Tarricone I, Bonora E, Tosato S, Lasalvia A, Szoke A, Arango C, Bernardo M, Bobes J, Del Ben C, Menezes P, Llorca P, Santos J, Sanjuan J, Arrojo M, Tortelli A, Velthorst E, Berendsen S, de Haan L, Rutten B, Lynskey M, Freeman T, Kirkbride J, Sham P, O’Donovan M, Cardno A, Vassos E, van Os J, Morgan C, Murray R, Lewis C, Di Forti M, EU-GEI Collaborators. Translational Psychiatry. 2021 Aug 10;11(1):423. doi: 10.1038/s41398-021-01526-0. PMID: 34376640

The independent effects of psychosocial stressors on subclinical psychosis: findings from the multinational EU-GEI Study. Pignon B, Lajnef M, Kirkbride JB, Peyre H, Ferchiou A, Richard JR, Baudin G, Tosato S, Jongsma H, de Haan L, Tarricone I, Bernardo M, Velthorst E, Braca M, Arango C, Arrojo M, Bobes J, Del-Ben CM, Di Forti M, Gayer-Anderson C, Jones PB, La Cascia C, Lasalvia A, Menezes PR, Quattrone D, Sanjuan J, Selten JP, Tortelli A, Llorca PM, van Os J, Rutten BPF, Murray RM, Morgan C, Leboyer M, Szoke A, Schurhoff F. Schizophrenia Bulletin. 2021 Oct 21;47(6):1674-1684. doi: 10.1093/schbul/sbab060. PMID: 34009318

The prevention of relapses in first episodes of schizophrenia: The 2EPs Project, background, rationale and study design. Bernardo M, Amoretti S, Cuesta MJ, Parellada M, Mezquida G, Gonzalez Pinto A, Berge D, Lobo A, Aguilar EJ, Usall J, Corripio I, Bobes J, Rodriguez Jimenez R, Sarro S, Contreras F, Ibanez A, Gutierrez M, Mico JA. Revista de Psiquiatria y Salud Mental. 2021;14(3):164-176. doi: 10.1016/j.rpsm.2020.07.004. PMID: 33020032

The prevention of relapses in first episodes of schizophrenia: the 2EPs Project, background, rationale and study design. Bernardo M, Amoretti S, Cuesta MJ, Parellada M, Mezquida G, Gonzalez-Pinto A, Berge D, Lobo A, Aguilar EJ, Usall J, Corripio I, Bobes J, Rodriguez-Jimenez R, Sarro S, Contreras F, Ibanez A, Gutierrez M, Mico JA. Revista de Psiquiatria y Salud Mental. 2021;14(3):164-176. doi: 10.1016/j.rpsmen.2021.08.001. PMID: 34456031

The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study. Ferraro L, La Cascia C, La Barbera D, Sanchez-Gutierrez T, Tripoli G, Seminerio F, Sartorio C, Marrazzo G, Sideli L, Arango C, Arrojo M, Bernardo M, Bobes J, Del-Ben C, Gayer-Anderson C, Jongsma H, Kirkbride J, Lasalvia A, Tosato S, Llorca P, Menezes P, Rutten B, Santos J, Sanjuan J, Selten J, Szoke A, Tarricone I, Muratori R, Tortelli A, Velthorst E, Rodriguez V, Quattrone A, Jones P, Van Os J, Vassos E, Morgan C, de Haan L, Reininghaus U, Cardno A, Di Forti M, Murray R, Quattrone D. Schizophrenia Research. 2021 Aug 14;236:69-79. doi: 10.1016/j.schres.2021.08.008. PMID: 34403965

The training of Psychiatry resident: Summary of the discussion table held during the XXII National Congress of Psychiatry. Spain, 2019. Martinez Uribe D, Etxeandia Pradera J, Bobes Garcia J, Moran-Barrios J, Ruiz De Gauna P, Saenz-Herrero M, Aguilar Garcia Iturrospe E. Revista de Psiquiatria y Salud Mental. 2021;14(1):74-76. doi: 10.1016/j.rpsm.2020.03.001. PMID: 32389515

The usefulness of olanzapine plasma concentrations in monitoring treatment efficacy and metabolic disturbances in first-episode psychosis. Arnaiz J, Rodrigues-Silva C, Mezquida G, Amoretti S, Cuesta M, Fraguas D, Lobo A, Gonzalez-Pinto A, Diaz-Caneja M, Corripio I, Vieta E, Baeza I, Mane A, Garcia-Rizo C, Bioque M, Saiz J, Bernardo M, Mas S, Balanza Martinez V. Psychopharmacology. 2021 Mar;238(3):665-676. doi: 10.1007/s00213-020-05715-5. PMID: 33230696

Training Psychiatry Residents in Descriptive Psychopathology: A Systematic Review. Etxeandia-Pradera J, Martinez-Uribe D, Bellver-Pradas F, Gonzalez-Piqueras J, Nacher J, Aguilar E. Psychopathology. 2021 Feb 19;1-17. doi: 10.1159/000512791. PMID: 33611314

Understanding emotions: origins and roles of the amígdala. Simic G, Tkalcic M, Vukic V, Mulc D, Spanic E, Sagud M, Olucha-Bordonau F, Vuksic M, Hof P. Biomolecules. 2021 May 31;11(6):823. doi: 10.3390/biom11060823. PMID: 34072960

When animals cry: the effect of adding tears to animal expressions on human judgment. Pico A, Gadea M. PLoS One. 2021 May 6;16(5):e0251083. doi: 10.1371/journal.pone.0251083. PMID: 33956813

Proyectos
Referencia: PI22/00507
Título: Reposicionamiento de fármacos como tratamiento para la enfermedad de Huntington y la ataxia espinocerebelosa de tipo 3. Estudios en cultivos primarios de pacientes y en modelos animales transgénicos.
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Federico V. Pallardó Calatayud, Juan Antonio Navarro Langa
Duración: 2023 – 2025
Presupuesto: 147.620,00 €
Referencia: PI22/01985
Título: Desarrollo y caracterización de nuevos modelos preclínicos celulares de medicina personalizada en psicosis
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Olga María Rivero Martín, Mª José Escartí Fabra
Duración: 2023 – 2025
Presupuesto: 117.370,00 €
Referencia: INVEST/2022/49
Título: Programa de formación y ocupabilidad de especialista en análisis de imagen de sistema nervioso
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: Juan Nácher Roselló
Duración: 2022 – 2024
Presupuesto: 66.218 €
Referencia: INVEST/2022/141
Título: Programa de formación y ocupabilidad de psicologo/a en evaluaciones clínicas y uso seguimiento del aplicativo remindcare en proyectos de investigación
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: Julio Sanjuán Arias
Duración: 2022 – 2024
Presupuesto: 66.218 €
Referencia: 2021095290
Título: Intracellular iron deposits in a Drosophila Model of Friedreich´s Ataxia
Entidad Financiadora: Center of Excellence ALBA synchrotron
Investigador principal: Juan Navarro Langa
Duración: 2022 – 2022
Presupuesto: 51.471 €
Referencia: PI20/00473
Título: Estudio longitudinal de una cohorte representativa: superando la heterogeneidad clínica y biológica en primeros episodios psicóticos
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Julio Sanjuán Arias
Duración: 2021 – 2025
Presupuesto: 68.970 €
Referencia: PROMETEO/2020/024
Título: Estudio longitudinal de una cohorte representativa: superando la heterogeneidad clínica y biológica en primeros episodios psicóticos
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: Julio Sanjuán Arias
Duración: 2020 – 2023
Presupuesto: 174.588 €
Referencia: RTI2018-098269-B-I00
Título: La matriz extracelular cerebral en la depresión: de modelos animales a pacientes
Entidad Financiadora: Ministerio de Ciencia e Innovación
Investigador principal: Juan Salvador Nácher Roselló
Duración: 2019 – 2021
Presupuesto: 217.800 €
Referencia: PI17/00402
Título: Resonancia magnética funcional y expresión génica como predictores en primeros episodios psicóticos
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Julio Sanjuán Arias
Duración: 2018 – 2020
Presupuesto: 110.231 €
Referencia:
Título: Identification of genetic factors involved on FXN transcriptional silencing mediated by the GAA repeat expasion
Entidad Financiadora: Friedreich’s Ataxia Research Alliance (FARA)
Investigador principal: Mª Dolores Moltó Ruiz
Duración: 2016 – 2019
Presupuesto: 154.576 €
Referencia: PROMETEO/2016/082
Título: Investigación de marcadores biológicos y nuevas estrategias terapéuticas en la Psicosis
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Julio Sanjuán Arias
Duración: 2016 – 2019
Presupuesto: 179.940 €
Referencia: SAF2015-68436-R
Título: Plasticity of perisomatic inhibition on pyramidal neurons of the prefrontal cortex: impact of peripubertal stress and implication in psychiatric disorder
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Juan Salvador Nácher Roselló
Duración: 2016 – 2019
Presupuesto: 193.600 €
Referencia: CB07/09/0006
Título: CIBER de Salud Mental (CIBERSAM)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Juan Salvador Nácher Roselló
Duración: 2008 –
Presupuesto:
+ Información
Empresa: Arthex Biotech
Año de inicio: 2019
Investigadores: Artero Allepuz, Rubén; Llamusí Troisi, Beatriz
Web: https://arthexbiotech.com/

Título: Paradigma auditivo en resonancia magnética funcional como marcador predictivo en primeros episodios psicóticos
Doctorando: González Vivas, Carlos
Director: Sanjuán Arias, Julio   
Fecha: 03/07/2023
Universidad: Universidad de Valencia

Título: La formación del residente de psiquiatría: intervenciones educativas para un mejor dominio y manejo clínico en psicofarmacología y salud mental
Doctorando: Martínez Uribe, Daniel Fernando
Director: Aguilar García Iturrospe, Eduardo Jesús; González Piqueras, José Carlos
Fecha: 25/05/2023
Universidad: Universidad de Valencia

Título: La enseñanza de la psicopatología descriptiva: estrategias educativas para la mejora de la formación de residentes de psiquiatría
Doctorando: Etxeandia Pradera, Jon Iñaki
Director: Aguilar Garcia Iturrospe, Eduardo Jesus
Fecha: 04/05/2023
Universidad: Universitat de València

Título: REMINDCARE: una aplicación para primeros episodios psicóticos integrada en la práctica clínica diaria
Doctorando: Bonet Mora, Lucía
Director: Sanjuán Arias, Julio   
Fecha: 16/07/2021
Universidad: Universitat de València

Título: Tears as powerful visual communication signals: a sociobiological approach
Doctorando: Picó Peris, Alfonso Ignacio
Director: Gadea Domènech, Maria Engracia
Fecha: 13/07/2021
Universidad: Universitat de València

Título: Hospitalización Domiciliaria en Salud Mental: eficacia y viabilidad
Doctorando: Ferrando Aparicio, Elvira
Director: Aguilar García Iturrospe, Eduardo Jesús; Silvestre Pascual, Francisca
Fecha: 07/07/2021
Universidad: Universitat de València

Título: Eficacia de un programa de rehabilitación de las funciones atencionales mediante tareas competitivas multijugador. Estudio clínico, neurofisiológico y neuroanatómico en pacientes con ictus
Doctorando: Navarro Pérez, Mª Dolores
Director: Lloréns Rodríguez, Roberto; Gadea Domènech, Maria Engracia; Noe Sebastián, Enrique
Fecha: 25/05/2021
Universidad: Universitat de València

Título: Continuous Neuronal Integration in the Cerebral Cortex of Rodents and Humans
Doctorando: Coviello, Simona
Director: Nácher Roselló, Juan Salvador; Castillo Gómez, Esther
Fecha: 30/03/2021
Universidad: Universitat de València

Título: Papel de núcleo incertus en el reconocimiento social a través de sus conexiones en el cerebro de rata
Doctorando: García Díaz, Cristina
Director: Olucha Bordonau, Francisco
Fecha: 29/03/2021
Universidad: Universidad Jaume I de Castellón

Título: Estudio de la plasticidad estructural en enfermedades psiquiátricas con modelos animales
Doctorando: Bueno Fernández, Clara
Director: Nácher Rosello, Juan Salvador; Castillo Gómez, Esther
Fecha: 09/03/2021
Universidad: Universitat de València

Título: Induction of neuronal plasticity during adulthood. Role of cortical interneurons and plasticity-related molecules
Doctorando: Carceller Cerdá, Héctor
Director: Guirado Guillén, Ramón; Nácher Roselló, Juan Salvador
Fecha: 28/02/2020
Universidad: Universitat de València

Título: El impacto de la fibromialgia en el núcleo familiar en un departamento de la Comunidad Valenciana
Doctorando: Vázquez Canales, Luz de Myotanh
Director: Aguilar García Iturrospe, Eduardo Jesús; Pereiró Berenguer, Inmaculada
Fecha: 10/01/2020
Universidad: Universitat de València

Título: Resonancia magnética funcional con paradigma emocional en pacientes con un primer episodio psicótico
Doctorando: Soldevila Matías, Pablo
Director: Sanjuan Arias, Julio; Espert Tortajada, Raúl; García Martí, Gracián
Fecha: 28/11/2019
Universidad: Universitat de València

Título: Analysis of structural plasticity in the adult and adolescent mouse brain. Effects of erythropoietin
Doctorando: Curto Sastre, Yasmina
Director: Nácher Roselló, Juan Salvador
Fecha: 08/07/2019
Universidad: Universitat de València

Título: Study of the population of immature neurons in the adult piriform cortex layer ii
Doctorando: Belles Esteller, María
Director: Nácher Roselló, Juan Salvador; Castillo Gómez, Esther
Fecha: 18/01/2019
Universidad: Universitat de València