Grupo de Investigación en Psiquiatría y Enfermedades Neurodegenerativas

Área de Metabolismo y Daño Orgánico

Elaboración de una aplicación móvil asociada a la Historia Clínica para mejorar la adherencia al tratamiento de pacientes con primer episodio de psicosis

Publicación de Resultados de Gen-Interacción Ambiental Proyectos de Primer Episodio de Psicosis

Desarrollo de nuevas técnicas-al diagnóstico de psicosis por fMRI y enfoque de aprendizaje automático

Desarrollo de modelos animales en trastornos mentales graves y enfermedades neurodegenerativas

Modelos de predicción de respuesta en primeros episodios psicóticos

Identificación de modificadores genéticos y epigenéticos y dianas moleculares en la Ataxia de Friedreich

Dr. Julio Sanjuán Arias
Coordinador
Dr. Julio Sanjuán Arias
julio.sanjuan@uv.es

INVESTIGADORES
R4 Senior

Julio Sanjuán Arias    

R3 Consolidado

Eduardo Jesús Aguilar García-Iturrospe
Juan Nacher Roselló
Mª Dolores Moltó Ruiz

R2 Novel / Emergente

Olga María Rivero Martín    
Carlos Cañete Nicolás
Esther Lorente Rovira
Francisco Olucha Bordonau
Gracián García Martí
José Carlos González Piqueras
Mª José Escartí Fabra
Marien Gadea Domenech
Marta Pérez Rando
Miguel Hernández Viadel

R1 Predoctoral

Javier David Lluesma
Jon Iñaki Etxeandia Pradera
Julia Alcaide Pozo
Lucía Bonet Mora

STAFF
Colaborador/a

Héctor Carceller Cerdá
Patrycja Klimczak

Enfermero/a

Blanca Llácer Iborra

Técnico/a
Apoyo

Julen Santiago Agrediano
Virginia Gómez Soriano

Publicaciones
A polygenic approach to the association between smoking and schizophrenia. Al-Soufi L, Martorell L, Molto MD, Gonzalez-Penas J, Garcia-Portilla MP, Arrojo M, Rivero O, Gutierrez-Zotes A, Nacher J, Muntane G, Paz E, Paramo M, Bobes J, Arango C, Sanjuan J, Vilella E, Costas J. Addiction Biology. 2022 Jan;27(1):e13104. doi: 10.1111/adb.13104. PMID: 34779080

Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations. Perez-Rando M, Elvira U, Garcia-Marti G, Gadea M, Aguilar E, Escarti M, Ahullo-Fuster M, Grasa E, Corripio I, Sanjuan J, Nacher J. NeuroImage Clinical. 2022 Jun 1;35:103070. doi: 10.1016/j.nicl.2022.103070. PMID: 35667173

Altered expression of vesicular glutamate transporter-2 and cleaved caspase-3 in the locus coeruleus of nerve-injured rats. Bravo L, Mariscal P, Llorca-Torralba M, Lopez-Cepero J, Nacher J, Berrocoso E. Frontiers in Molecular Neuroscience. 2022 Jul 27;15:918321. doi: 10.3389/fnmol.2022.918321. PMID: 35966012

Author Correction: Persons with first episode psychosis have distinct profiles of social cognition and metacognition. Ferrer-Quintero M, Fernandez D, Lopez-Carrilero R, Birules I, Barajas A, Lorente-Rovira E, Diaz-Cutraro L, Verdaguer M, Garcia-Mieres H, Sevilla-Llewellyn-Jones J, Gutierrez-Zotes A, Grasa E, Pousa E, Huerta-Ramos E, Pelaez T, Barrigon M, Gonzalez-Higueras F, Ruiz-Delgado I, Cid J, Moritz S, Ochoa S, Spanish Metacognition Grp. NPJ schizophrenia. 2022 Feb 24;8(1):3. doi: 10.1038/s41537-021-00199-4. PMID: 35210466

Brain activity changes with emotional words in different stages of psychosis. Soldevila-Matias P, Garcia-Marti G, Fuentes-Dura I, Ruiz JC, Gonzalez-Navarro L, Gonzalez-Vivas C, Radua J, Sanjuan J. European Psychiatry. 2022 Oct 4;1-27. doi: 10.1192/j.eurpsy.2022.2321. PMID: 36193735

Childhood maltreatment, educational attainment, and IQ: findings from a Multicentric Case-control Study of First-episode Psychosis (EU-GEI). Sideli L, Schimmenti A, La Barbera D, La Cascia C, Ferraro L, Aas M, Alameda L, Velthorst E, Fisher H, Caretti V, Trotta G, Tripoli G, Quattrone D, Gayer-Anderson C, Seminerio F, Sartorio C, Marrazzo G, Lasalvia A, Tosato S, Tarricone I, Berardi D, D’Andrea G, Arango C, Arrojo M, Bernardo M, Bobes J, Sanjuan J, Santos J, Menezes P, Del-Ben C, Jongsma H, Jones P, Kirkbride J, Llorca P, Tortelli A, Pignon B, de Haan L, Selten J, Van Os J, Rutten B, Di Forti M, Morgan C, Murray R, EU-GEI WP2 Group. Schizophrenia Bulletin. 2022 May 7;48(3):575-589. doi: 10.1093/schbul/sbac004. PMID: 35137235

Cortical thinning over two years after first-episode psychosis depends on age of onset. Pina-Camacho L, Martinez K, Diaz-Caneja C, Mezquida G, Cuesta M, Moreno C, Amoretti S, Gonzalez-Pinto A, Arango C, Vieta E, Castro-Fornieles J, Lobo A, Fraguas D, Bernardo M, Janssen J, Parellada M, PEPs Group. NPJ Schizophrenia. 2022 Mar 11;8(1):20. doi: 10.1038/s41537-021-00196-7. PMID: 35277520

Estradiol regulates PSA-NCAM expression and connectivity of O-LM interneurons in the hippocampus of adult female mice. Perez-Rando M, Guirado R, Tellez-Merlo G, Carceller H, Nacher J. Neuroendocrinology. 2022;112(1):51-67. doi: 10.1159/000515052. PMID: 33550289

EUROLD: preliminary results of the ecological study on suicide and its associated socioeconomic variables in people over 85 in Europe. Rodriguez Ruzafa M, Carrasco Picazo JP, Junquera Fernandez G, Aguilar Garcia-Iturrospe EJ. International Psychogeriatrics. 2022 Feb 28;1-3. doi: 10.1017/S1041610222000072. PMID: 35225213

Examining facial emotion recognition as an intermediate phenotype for psychosis: findings from the EUGEI study. Fusar-Poli L, Pries L, van Os J, Erzin G, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Aguglia E, Arango C, O’Donovan M, Rutten B, Guloksuz S, Genetic Risk Outcome Psychosis Grp. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2022 Mar 8;113:110440. doi: 10.1016/j.pnpbp.2021.110440. PMID: 34536513

Facial emotion recognition in psychosis and associations with polygenic risk for schizophrenia: findings from the multi-center EU-GEI case-control study. Tripoli G, Quattrone D, Ferraro L, Gayer-Anderson C, La Cascia C, La Barbera D, Sartorio C, Seminerio F, Rodriguez V, Tarricone I, Berardi D, Jamain S, Arango C, Tortelli A, Llorca P, de Haan L, Velthorst E, Bobes J, Bernardo M, Sanjuan J, Santos J, Arrojo M, Del-Ben C, Menezes P, van der Ven E, Jones P, Jongsma H, Kirkbride J, Tosato S, Lasalvia A, Richards A, O’Donovan M, Rutten B, van Os J, Morgan C, Sham P, Di Forti M, Murray R, Murray G. Schizophrenia Bulletin. 2022 Sep 1;48(5):1104-1114. doi: 10.1093/schbul/sbac022. PMID: 35325253

Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study. Pignon B, Peyre H, Ayrolles A, Kirkbride JB, Jamain S, Ferchiou A, Richard JR, Baudin G, Tosato S, Jongsma H, de Haan L, Tarricone I, Bernardo M, Velthorst E, Braca M, Arango C, Arrojo M, Bobes J, Del-Ben CM, Di Forti M, Gayer-Anderson C, Jones PB, La Cascia C, Lasalvia A, Menezes PR, Quattrone D, Sanjuan J, Selten JP, Tortelli A, Llorca PM, van Os J, Rutten BPF, Murray RM, Morgan C, Leboyer M, Szoke A, Schurhoff F. Epidemiology and Psychiatric Sciences. 2022 Sep 27;31:e68. doi: 10.1017/S2045796022000464. PMID: 36165168

How to Improve Training in Descriptive Psychopathology for Psychiatry Residents: A Delphi Study. Etxeandia-Pradera J, Landeta J, Gonzalez-Such J, Aguilar E. Psychopathology. 2022 Jul 29;1-14. doi: 10.1159/000525691. PMID: 35908537

How voices change the brain. Two fMRI follow-up case reports. Gonzalez-Vivas C, Valdes-Florido MJ, Garcia-Marti G, Soldevila-Matias P, Marti-Bonmati L, Nacher J, Sanjuan J. Schizophrenia Research. 2022 Oct;248:329-330. doi: 10.1016/j.schres.2022.09.016. PMID: 36155306

Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen. Perez-Rando M, Carceller H, Castillo-Gomez E, Bueno-Fernandez C, Garcia-Mompo C, Gilabert-Juan J, Guirado R, Pesarico A, Nacher J. Neurobiology of Stress. 2022 May 13;19:100460. doi: 10.1016/j.ynstr.2022.100460. PMID: 35734023

Impaired recollection and initially preserved familiarity in a patient with bilateral fornix transection following third ventricle colloid cyst removal: A two-year follow-up study. Fuentes M, Sales A, Charquero-Ballester M, Garcia-Marti G, Melendez J, Espert R, Scheel M, Bauknecht H, Simon K, Kopstein U, Gebauer S, Algarabel S. Applied Neuropsychology-Adult. 2022 Aug 2;1-13. doi: 10.1080/23279095.2022.2104162. PMID: 35917584

Long term effects of 24-h-restraint stress on the connectivity and structure of interneurons in the basolateral amygdala. Pesarico A, Carceller H, Guirado R, Coviello S, Nacher J. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2022 Apr 20;115:110512. doi: 10.1016/j.pnpbp.2022.110512. PMID: 35066055

Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Trubetskoy V, Pardinas A, Qi T, Panagiotaropoulou G, Indonesia Schizophrenia Consortium, PsychENCODE, Psychosis Endophenotypes International Consortium, SynGO Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature. 2022 Apr 8. doi: 10.1038/s41586-022-04434-5. PMID: 35396580

Perineuronal nets: subtle structures with large implications. Carceller H, Gramuntell Y, Klimczak P, Nacher J. Neuroscientist. 2022 Jul 23;10738584221106346. doi: 10.1177/10738584221106346. PMID: 35872660

Phenotype and distribution of immature neurons in the human cerebral cortex layer II. Coviello S, Gramuntell Y, Klimczak P, Varea E, Blasco-Ibanez J, Crespo C, Gutierrez A, Nacher J. Frontiers in Neuroanatomy. 2022 Apr 8;16:851432. doi: 10.3389/fnana.2022.851432. PMID: 35464133

Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. Andreu-Bernabeu Á, Díaz-Caneja CM, Costas J, De Hoyos L, Stella C, Gurriarán X, Alloza C, Fañanás L, Bobes J, González-Pinto A, Crespo-Facorro B, Martorell L, Vilella E, Muntané G, Nacher J, Molto MD, Aguilar EJ, Parellada M, Arango C, González-Peñas J. Nature Communications. 2022 Jan 10;13(1):51. doi: 10.1038/s41467-021-27598-6. PMID: 35013163

Prenatal development of the human entorhinal cortex. Simic G, Krsnik Z, Knezovic V, Kelovic Z, Mathiasen M, Junakovic A, Rados M, Mulc D, Spanic E, Quattrocolo G, Hall V, Zaborszky L, Vuksic M, Bordonau F, Kostovic I, Witter M, Hof P. Journal of Comparative Neurology. 2022 Oct;530(15):2711-2748. doi: 10.1002/cne.25344. PMID: 35603771

Relapse of first-episode schizophrenia patients and neurocognitive impairment: the role of dopaminergic and anticholinergic burden. Cuesta MJ, Ballesteros A, Sanchez-Torres AM, Amoretti S, Lopez-Ilundain JM, Merchan-Naranjo J, Gonzalez-Ortega I, Salgado P, Rodriguez-Jimenez R, Roldan-Bejarano A, Sarro S, Ibanez A, Usall J, Escarti MJ, Moreno-Izco L, Mezquida G, Parellada M, Gonzalez-Pinto A, Berrocoso E, Bernardo M. Schizophrenia Research. 2022 Oct;248:331-340. doi: 10.1016/j.schres.2022.09.014. PMID: 36155307

The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. Fusar-Poli L, Pries LK, van Os J, Radhakrishnan R, Pence AY, Erzin G, Delespaul P, Kenis G, Luykx JJ, Lin BD, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran ES, Kaymak SU, Mihaljevic MM, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz PA, Garcia-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric NP, Atbasoglu C, Ucok A, Alptekin K, Saka MC, Aguglia E, Arango C, Rutten BP, Guloksuz S. European Neuropsychopharmacology. 2022 Aug 30;63:47-59. doi: 10.1016/j.euroneuro.2022.08.003. PMID: 36055075

The network structure of cognitive deficits in first episode psychosis patients. Sanchez-Torres A, Peralta V, Gil-Berrozpe G, Mezquida G, Ribeiro M, Molina-Garcia M, Amoretti S, Lobo A, Gonzalez-Pinto A, Merchan-Naranjo J, Corripio I, Vieta E, de la Serna E, Berge D, Bernardo M, Cuesta M, Aguilar Garcia Iturrospe E, PEPs Group, PEPs Group. Schizophrenia Research. 2022 Jun;244:46-54. doi: 10.1016/j.schres.2022.05.005. PMID: 35594732

The parietal lobe in Alzheimer’s disease and blindness. Ahullo-Fuster MA, Ortiz T, Varela-Donoso E, Nacher J, Sanchez-Sanchez ML. Journal of Alzheimer’s Disease. 2022 Sep 8. doi: 10.3233/JAD-220498. PMID: 36093700

The role of BDNF and NGF plasma levels in first-episode schizophrenia: a longitudinal study. Martinez Pinteno A, Mezquida G, Bioque M, Lopez Ilundain JM, Andreu Bernabeu A, Zorrilla I, Mane A, Rodriguez Jimenez R, Corripio I, Sarro S, Ibanez A, Usall J, Rivero O, Gasso P, Leza JC, Cuesta MJ, Parellada M, Gonzalez Pinto A, Berrocoso E, Mas S, Bernardo M. European Neuropsychopharmacology. 2022 Feb 23;57:105-117. doi: 10.1016/j.euroneuro.2022.02.003. PMID: 35219096

Variables associated with the success of group cognitive behavioral therapy for insomnia: preliminary results. Terres-Jimenez B, Dominguez-Cabanero EM, Gonzalez-Vivas C, Garcia-Parreno B, Diego-Castano S, Aiko Gesler M, De Entrambasaguas M, Lorente-Rovira E. Actas Espanolas de Psiquiatria. 2022 Sep;50(5):233-240. Epub 2022 Sep 1. PMID: 36273383

When the front fails, the rear wins. Cerebellar correlates of prefrontal dysfunction in cocaine-induced memory in male rats. Guarque-Chabrera J, Gil-Miravet I, Olucha-Bordonau F, Melchor-Eixea I, Miquel M. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2022 Jan 10;112:110429. doi: 10.1016/j.pnpbp.2021.110429. PMID: 34416354

A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood. Gasso P, Rodriguez N, Martinez-Pinteno A, Mezquida G, Ribeiro M, Gonzalez-Penas J, Zorrilla I, Martinez-Sadurni L, Rodriguez-Jimenez R, Corripio I, Sarro S, Ibanez A, Usall J, Lobo A, Moren C, Cuesta M, Parellada M, Gonzalez-Pinto A, Berrocoso E, Bernardo M, Mas S, 2EPs Grp. Translational Psychiatry. 2021 Oct 19;11(1):539. doi: 10.1038/s41398-021-01645-8. PMID: 34667144

A multicentre, randomised, controlled trial of a combined clinical treatment for first-episode psychosis. Gonzalez-Ortega I, Vega P, Echeburua E, Alberich S, Fernandez-Sevillano J, Barbeito S, Balanza-Martinez V, Vieta E, Lorente-Rovira E, Luengo A, Cerrillo E, Crespo J, Matute C, Gonzalez-Pinto A. International Journal of Environmental Research and Public Health. 2021 Jul 6;18(14):7239. doi: 10.3390/ijerph18147239. PMID: 34299697

Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Fernandez Garcia-Agudo L, Steixner-Kumar AA, Curto Y, Barnkothe N, Hassouna I, Jahne S, Butt UJ, Grewe K, Weber MS, Green K, Rizzoli S, Nacher J, Nave KA, Ehrenreich H. Cell Reports. 2021 Aug 24;36(8):109548. doi: 10.1016/j.celrep.2021.109548. PMID: 34433021

Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings. Velthorst E, Mollon J, Murray R, de Haan L, Germeys I, Glahn D, Arango C, van der Ven E, Di Forti M, Bernardo M, Guloksuz S, Delespaul P, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Santos J, Jimenez-Lopez E, Sanjuan J, Aguilar E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Atbasoglu C, Saka M, Ucok A, Alptekin K, Akdede B, Binbay T, Altinyazar V, Ulas H, Yalincetin B, Gumus-AkaY G, Beyaz B, Soygur H, Cankurtaran E, Kaymak S, Maric N, Mihaljevic M, Petrovic S, Mirjanic T, Del-Ben C, Ferraro L, Gayer-Anderson C, Jones P, Jongsma H, Kirkbride J, La Cascia C, Lasalvia A, Tosato S, Llorca P, Menezes P, Morgan C, Quattrone D, Menchetti M, Selten J, Szoke A, Tarricone I, Tortelli A, McGuire P, Valmaggia L, Kempton M, van der Gaag M, Riecher-Rossler A, Bressan R, Barrantes-Vidal N, Nelson B, McGorry P, Pantelis C, Krebs M, Ruhrmann S, Sachs G, Rutten B, van Os J, Alizadeh B, van Amelsvoort T, Bartels-Velthuis A, Bruggeman R, van Beveren N, Luykx J, Cahn W, Simons C, Kahn R, Schirmbeck F, van Winkel R, Reichenberg A, EU-GEI High Risk Study. Molecular Psychiatry. 2021 Aug;26(8):4529-4543. doi: 10.1038/s41380-020-00969-z. PMID: 33414498

COVID-19 lockdown influence in the psychiatric emergencies: Drastic reduction and increase in severe mental disorders. Carrasco JP, Herraiz B, Sanchez LO, Luengo A, Fusalba OR, Aguilar EJ. Revista de Psiquiatria y Salud Mental. 2021;14(2):117-118. doi: 10.1016/j.rpsm.2020.11.003. PMID: 33248289

Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results from the multi-center EU-GEI Study. Ajnakina O, Rodriguez V, Quattrone D, di Forti M, Vassos E, Arango C, Berardi D, Bernardo M, Bobes J, de Haan L, Del-Ben CM, Gayer-Anderson C, Jongsma HE, Lasalvia A, Tosato S, Llorca PM, Menezes PR, Rutten BP, Santos JL, Sanjuan J, Selten JP, Szoke A, Tarricone I, D’Andrea G, Richards A, Tortelli A, Velthorst E, Jones PB, Arrojo Romero M, La Cascia C, Kirkbride JB, van Os J, O’Donovan M, Murray RM. Schizophrenia Bulletin. 2021 Oct 21;47(6):1653-1662. doi: 10.1093/schbul/sbab055. PMID: 33963865

Editorial: Animal models of stress – current knowledge and potential directions. Pesarico A, Chagas P, Nacher J. Frontiers in Behavioral Neuroscience. 2021 Feb 16;15:655214. doi: 10.3389/fnbeh.2021.655214. PMID: 33664658

Effects of aging on the structure and expression of NMDA receptors of somatostatin expressing neurons in the mouse hippocampus. Gramuntell Y, Klimczak P, Coviello S, Perez-Rando M, Nacher J. Frontiers in Aging Neuroscience. 2021 Dec 23;13:782737. doi: 10.3389/fnagi.2021.782737. PMID: 35002680

Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: results from the EUGEI study. Erzin G, Pries L, van Os J, Fusar-Poli L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O’Donovan M, Rutten B, Guloksuz S, Genetic Risk and Outcome of Psychosis (GROUP) investigators. European psychiatry. 2021 Mar 19;64(1):e25. doi: 10.1192/j.eurpsy.2021.19. PMID: 33736735

Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity. Casquero-Veiga M, Bueno-Fernandez C, Romero-Miguel D, Lamanna-Rama N, Nacher J, Desco M, Soto-Montenegro M. Scientific Reports. 2021 Mar 10;11(1):5580. doi: 10.1038/s41598-021-82987-7. PMID: 33692388

FOXP2 expression and gray matter density in the male brains of patients with schizophrenia. Sanjuan Arias J, Castro-Martinez X, Garcia Marti G, Gonzalez-Fernandez J, Sanz-Requena R, Haro J, Meana J, Marti-Bonmati L, Nacher Roselló J, Sebastia Ortega N, Gilabert Juan J, Moltó Ruiz M. Brain Imaging and Behavior. 2021 Jun;15(3):1403-1411. doi: 10.1007/s11682-020-00339-x. PMID: 32734433

From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine-related cues. Gil-Miravet I, Melchor-Eixea I, Arias-Sandoval E, Vasquez-Celaya L, Guarque-Chabrera J, Olucha Bordonau F, Miquel M. Addiction Biology. 2021 Jan;26(1):e12834. doi: 10.1111/adb.12834. PMID: 31808992

Grey matter microstructural alterations in schizophrenia patients with treatment-resistant auditory verbal hallucinations. Sampedro F, Roldan A, Alonso-Solis A, Grasa E, Portella MJ, Aguilar EJ, Nunez-Marin F, Gomez-Anson B, Corripio I. Journal of Psychiatric Research. 2021 Jun;138:130-138. doi: 10.1016/j.jpsychires.2021.03.037. PMID: 33852993

Induced dipoles and possible modulation of wireless effects in implanted electrodes. effects of implanting insulated electrodes on an animal test to screen antidepressant activity. Perez-Caballero L, Carceller H, Nacher J, Teruel-Marti V, Pujades E, Casan-Pastor N, Berrocoso E. Journal of Clinical Medicine. 2021 Sep 4;10(17):4003. doi: 10.3390/jcm10174003. PMID: 34501451

Involvement of the nucleus incertus and relaxin-3/RXFP3 signaling system in explicit and implicit memory. Gil-Miravet I, Manas-Ojeda A, Ros-Bernal F, Castillo-Gomez E, Albert-Gasco H, Gundlach A, Olucha-Bordonau F. Frontiers in Neuroanatomy. 2021 Mar 18;15:637922. doi: 10.3389/fnana.2021.637922. PMID: 33867946

Jumping to conclusions and suicidal behavior in depression and psychosis. Sastre-Buades A, Ochoa S, Lorente-Rovira E, Barajas A, Grasa E, Lopez-Carrilero R, Luengo A, Ruiz-Delgado I, Cid J, Gonzalez-Higueras F, Sanchez-Alonso S, Baca-Garcia E, Barrigon M, Spanish Metacognition Study Grp. Journal of Psychiatric Research. 2021 May;137:514-520. doi: 10.1016/j.jpsychires.2021.03.024. PMID: 33812324

Jumping to conclusions, general intelligence, and psychosis liability: findings from the multi-centre EU-GEI case-control study.. Tripoli G, Quattrone D, Ferraro L, Gayer-Anderson C, Rodriguez V, La Cascia C, La Barbera D, Sartorio C, Seminerio F, Tarricone I, Berardi D, Szoke A, Arango C, Tortelli A, Llorca P, de Haan L, Velthorst E, Bobes J, Bernardo M, Sanjuan Arias J, Santos J, Arrojo M, Del-Ben C, Menezes P, Selten J, Jones P, Jongsma H, Kirkbride J, Lasalvia A, Tosato S, Richards A, O’Donovan M, Rutten B, Os J, Morgan C, Sham P, Murray R, Murray G, Di Forti M, EU-GEI WP2 Group. Psychological Medicine. 2021 Mar;51(4):623-633. doi: 10.1017/S003329171900357X. PMID: 32327005

Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice. Bueno-Fernandez C, Perez-Rando M, Alcaide J, Coviello S, Sandi C, Castillo-Gomez E, Nacher J. Neurobiology of Stress. 2021 Apr 1;14:100322. doi: 10.1016/j.ynstr.2021.100322. PMID: 33869684

Migration history and risk of psychosis: results from the multinational EU-GEI study. Tarricone I, D’Andrea G, Jongsma H, Tosato S, Gayer-Anderson C, Stilo S, Suprani F, Iyegbe C, van der Ven E, Quattrone D, di Forti M, Velthorst E, Rossi Menezes P, Arango C, Parellada M, Lasalvia A, La Cascia C, Ferraro L, Bobes J, Bernardo M, Sanjuan I, Santos J, Arrojo M, Del-Ben C, Tripoli G, Llorca P, de Haan L, Selten J, Tortelli A, Szoke A, Muratori R, Rutten B, van Os J, Jones P, Kirkbride J, Berardi D, Murray R, Morgan C. Psychological Medicine. 2021 Feb 10;1-13. doi: 10.1017/S003329172000495X. PMID: 33563347

Moderators of cognitive insight outcome in metacognitive training for first-episode psychosis. Gonzalez-Blanch C, Birules I, Pousa E, Barrigon M, Lopez-Carrilero R, Lorente-Rovira E, Ayesa-Arriola R, Setien-Suero E, Barajas A, Grasa E, Ruiz-Delgado I, Gonzalez-Higueras F, Cid J, Ochoa S. Journal of Psychiatric Research. 2021 Sep;141:104-110. doi: 10.1016/j.jpsychires.2021.06.040. PMID: 34186271

Motor abnormalities and basal ganglia in first-episode psychosis (FEP). Cuesta M, Lecumberri P, Moreno-Izco L, Lopez-Ilundain J, Ribeiro M, Cabada T, Lorente-Omenaca R, de Erausquin G, Garcia Marti G, Sanjuan Arias J, Sanchez-Torres A, Gomez M, Peralta V. Psychological Medicine. 2021 Jul;51(10):1625-1636. doi: 10.1017/S0033291720000343. PMID: 32114994

Neuroimaging correlates of insight in non-affective psychosis: a systematic review and meta-analysis. Soldevila-Matias P, Schoretsanitis G, Tordesillas-Gutierrez D, Cuesta M, de Filippis R, Ayesa-Arriola R, Gonzalez-Vivas C, Setien-Suero E, Verdolini N, Sanjuan J, Radua J, Crespo-Facorro B. Revista de Psiquiatria y Salud Mental. 2021 Jul 13:S1888-9891(21)00067-7. doi: 10.1016/j.rpsm.2021.07.001. PMID: 34271162

No Effects of Acute Psychosocial Stress on Working Memory in Older People With Type 2 Diabetes. Vallejo L, Zapater-Fajari M, Montoliu T, Puig-Perez S, Nacher J, Hidalgo V, Salvador A. Frontiers in Psychology. 2021 Jan 7;11:596584. doi: 10.3389/fpsyg.2020.596584. PMID: 33584433

Parvalbumin interneurons and perineuronal nets in the hippocampus and retrosplenial cortex of adult male mice after early social isolation stress and perinatal NMDA receptor antagonist treatment. Klimczak P, Rizzo A, Castillo-Gomez E, Perez-Rando M, Gramuntell Y, Beltran M, Nacher J. Frontiers in Synaptic Neuroscience. 2021 Sep 22;13:733989. doi: 10.3389/fnsyn.2021.733989. PMID: 34630066

Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study. Misra S, Gelaye B, Williams D, Koenen K, Borba C, Quattrone D, Di Forti M, Tripoli G, La Cascia C, La Barbera D, Ferraro L, Tarricone I, Berardi D, Lasalvia A, Tosato S, Szoke A, Llorca P, Arango C, Tortelli A, de Haan L, Velthorst E, Bobes J, Bernardo M, Sanjuan J, Santos J, Arrojo M, Del-Ben C, Menezes P, Selten J, Jones P, Jongsma H, Kirkbride J, Rutten B, van Os J, Murray R, Gayer-Anderson C, Morgan C. Psychological Medicine. 2021 Mar 2;1-9. doi: 10.1017/S0033291721000453. PMID: 33648622

Persons with first episode psychosis have distinct profiles of social cognition and metacognition. Ferrer-Quintero M, Fernandez D, Lopez-Carrilero R, Birules I, Barajas A, Lorente-Rovira E, Diaz-Cutraro L, Verdaguer M, Garcia-Mieres H, Sevilla-Llewellyn-Jones J, Gutierrez-Zotes A, Grasa E, Pousa E, Huerta-Ramos E, Pelaez T, Barrigon ML, Gonzalez-Higueras F, Ruiz-Delgado I, Cid J, Moritz S, Ochoa S. NPJ Schizophrenia. 2021 Dec 9;7(1):61. doi: 10.1038/s41537-021-00187-8. PMID: 34887442

Pre-training inter-rater reliability of clinical instruments in an international psychosis research Project. Berendsen S, Kapitein P, Schirmbeck F, van Tricht M, McGuire P, Morgan C, Gayer-Anderson C, Kempton M, Valmaggia L, Quattrone D, di Forti M, van der Gaag M, Kirkbride J, Jongsma H, Jones P, Parellada M, Arango C, Arrojo M, Bernardo M, Sanjuan Arias J, Santos J, Szoke A, Tortelli A, Llorca P, Tarricone I, Tripoli G, Ferraro L, La Cascia C, Lasalvia A, Tosato S, Menezes P, Del-Ben C, Nelson B, Riecher-Rossler A, Bressan R, Barrantes-Vidal N, Krebs M, Nordentoft M, Ruhrmann S, Sachs G, Rutten B, van Os J, Velthorst E, de Haan L, EU-GEI High Risk Study. Schizophrenia Research. 2021 Apr;230:104-107. doi: 10.1016/j.schres.2020.08.001. PMID: 33243716

PSA Depletion Induces the Differentiation of Immature Neurons in the Piriform Cortex of Adult Mice. Coviello S, Benedetti B, Jakubecova D, Belles M, Klimczak P, Gramuntell Y, Couillard-Despres S, Nacher J. International journal of molecular sciences. 2021 May 27;22(11):5733. doi: 10.3390/ijms22115733. PMID: 34072166

Rabphilin silencing causes dilated cardiomyopathy in a Drosophila model of nephrocyte damage. Selma-Soriano E, Casillas-Serra C, Artero R, Llamusi B, Navarro J, Redon J. Scientific Reports. 2021 Jul 27;11(1):15287. doi: 10.1038/s41598-021-94710-7. PMID: 34315987

Relationship between cognition and age at onset of first-episode psychosis: comparative study between adolescents, young adults, and adults. De la Serna E, Puig O, Mezquida G, Moreno-Izco L, Merchan-Naranjo J, Amoretti S, Ruiz P, Gonzalez-Pinto A, Molina-Garcia M, Corripio I, Vieta E, Baeza I, Berge D, Penades R, Sanchez-Torres A, Cuesta M, Bernardo M, Castro-Fornieles J, PEPs Group. European Child & Adolescent Psychiatry. 2021 Oct 29. doi: 10.1007/s00787-021-01901-8. PMID: 34714406

Relaxin-3 innervation from the nucleus incertus to the parahippocampal cortex of the rat. Garcia-Diaz C, Gil-Miravet I, Albert-Gasco H, Manas-Ojeda A, Ros-Bernal F, Castillo-Gomez E, Gundlach A, Olucha-Bordonau F. Frontiers in Neuroanatomy. 2021 Jun 22;15:674649. doi: 10.3389/fnana.2021.674649. PMID: 34239421

ReMindCare, an app for daily clinical practice in patients with first episode psychosis: A pragmatic real-world study protocol. Bonet Mora L, Torous J, Arce D, Blanquer I, Sanjuan Arias J. Early Intervention In Psychiatry. 2021 Feb;15(1):183-192. doi: 10.1111/eip.12960. PMID: 32253830

Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis: results from the EU-GEI case-control study. Jongsma H, Gayer-Anderson C, Tarricone I, Velthorst E, van der Ven E, Quattrone D, di Forti M, Menezes P, Del-Ben C, Arango C, Lasalvia A, Berardi D, La Cascia C, Bobes J, Bernardo M, Sanjuan Arias J, Santos J, Arrojo M, de Haan L, Tortelli A, Szoke A, Murray R, Rutten B, van Os J, Morgan C, Jones P, Kirkbride J, EU-GEI WP2 Group. Psychological Medicine. 2021 Jul;51(9):1536-1548. doi: 10.1017/S003329172000029X. PMID: 32122439

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study. Quattrone D, Reininghaus U, Richards A, Tripoli G, Ferraro L, Quattrone A, Marino P, Rodriguez V, Spinazzola E, Gayer-Anderson C, Jongsma H, Jones P, La Cascia C, La Barbera D, Tarricone I, Bonora E, Tosato S, Lasalvia A, Szoke A, Arango C, Bernardo M, Bobes J, Del Ben C, Menezes P, Llorca P, Santos J, Sanjuan J, Arrojo M, Tortelli A, Velthorst E, Berendsen S, de Haan L, Rutten B, Lynskey M, Freeman T, Kirkbride J, Sham P, O’Donovan M, Cardno A, Vassos E, van Os J, Morgan C, Murray R, Lewis C, Di Forti M, EU-GEI Collaborators. Translational Psychiatry. 2021 Aug 10;11(1):423. doi: 10.1038/s41398-021-01526-0. PMID: 34376640

The independent effects of psychosocial stressors on subclinical psychosis: findings from the multinational EU-GEI Study. Pignon B, Lajnef M, Kirkbride JB, Peyre H, Ferchiou A, Richard JR, Baudin G, Tosato S, Jongsma H, de Haan L, Tarricone I, Bernardo M, Velthorst E, Braca M, Arango C, Arrojo M, Bobes J, Del-Ben CM, Di Forti M, Gayer-Anderson C, Jones PB, La Cascia C, Lasalvia A, Menezes PR, Quattrone D, Sanjuan J, Selten JP, Tortelli A, Llorca PM, van Os J, Rutten BPF, Murray RM, Morgan C, Leboyer M, Szoke A, Schurhoff F. Schizophrenia Bulletin. 2021 Oct 21;47(6):1674-1684. doi: 10.1093/schbul/sbab060. PMID: 34009318

The prevention of relapses in first episodes of schizophrenia: The 2EPs Project, background, rationale and study design. Bernardo M, Amoretti S, Cuesta MJ, Parellada M, Mezquida G, Gonzalez Pinto A, Berge D, Lobo A, Aguilar EJ, Usall J, Corripio I, Bobes J, Rodriguez Jimenez R, Sarro S, Contreras F, Ibanez A, Gutierrez M, Mico JA. Revista de Psiquiatria y Salud Mental. 2021;14(3):164-176. doi: 10.1016/j.rpsm.2020.07.004. PMID: 33020032

The prevention of relapses in first episodes of schizophrenia: the 2EPs Project, background, rationale and study design. Bernardo M, Amoretti S, Cuesta MJ, Parellada M, Mezquida G, Gonzalez-Pinto A, Berge D, Lobo A, Aguilar EJ, Usall J, Corripio I, Bobes J, Rodriguez-Jimenez R, Sarro S, Contreras F, Ibanez A, Gutierrez M, Mico JA. Revista de Psiquiatria y Salud Mental. 2021;14(3):164-176. doi: 10.1016/j.rpsmen.2021.08.001. PMID: 34456031

The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study. Ferraro L, La Cascia C, La Barbera D, Sanchez-Gutierrez T, Tripoli G, Seminerio F, Sartorio C, Marrazzo G, Sideli L, Arango C, Arrojo M, Bernardo M, Bobes J, Del-Ben C, Gayer-Anderson C, Jongsma H, Kirkbride J, Lasalvia A, Tosato S, Llorca P, Menezes P, Rutten B, Santos J, Sanjuan J, Selten J, Szoke A, Tarricone I, Muratori R, Tortelli A, Velthorst E, Rodriguez V, Quattrone A, Jones P, Van Os J, Vassos E, Morgan C, de Haan L, Reininghaus U, Cardno A, Di Forti M, Murray R, Quattrone D. Schizophrenia Research. 2021 Aug 14;236:69-79. doi: 10.1016/j.schres.2021.08.008. PMID: 34403965

The training of Psychiatry resident: Summary of the discussion table held during the XXII National Congress of Psychiatry. Spain, 2019. Martinez Uribe D, Etxeandia Pradera J, Bobes Garcia J, Moran-Barrios J, Ruiz De Gauna P, Saenz-Herrero M, Aguilar Garcia Iturrospe E. Revista de Psiquiatria y Salud Mental. 2021;14(1):74-76. doi: 10.1016/j.rpsm.2020.03.001. PMID: 32389515

The usefulness of olanzapine plasma concentrations in monitoring treatment efficacy and metabolic disturbances in first-episode psychosis. Arnaiz J, Rodrigues-Silva C, Mezquida G, Amoretti S, Cuesta M, Fraguas D, Lobo A, Gonzalez-Pinto A, Diaz-Caneja M, Corripio I, Vieta E, Baeza I, Mane A, Garcia-Rizo C, Bioque M, Saiz J, Bernardo M, Mas S, Balanza Martinez V. Psychopharmacology. 2021 Mar;238(3):665-676. doi: 10.1007/s00213-020-05715-5. PMID: 33230696

Training Psychiatry Residents in Descriptive Psychopathology: A Systematic Review. Etxeandia-Pradera J, Martinez-Uribe D, Bellver-Pradas F, Gonzalez-Piqueras J, Nacher J, Aguilar E. Psychopathology. 2021 Feb 19;1-17. doi: 10.1159/000512791. PMID: 33611314

Understanding emotions: origins and roles of the amígdala. Simic G, Tkalcic M, Vukic V, Mulc D, Spanic E, Sagud M, Olucha-Bordonau F, Vuksic M, Hof P. Biomolecules. 2021 May 31;11(6):823. doi: 10.3390/biom11060823. PMID: 34072960

When animals cry: the effect of adding tears to animal expressions on human judgment. Pico A, Gadea M. PLoS One. 2021 May 6;16(5):e0251083. doi: 10.1371/journal.pone.0251083. PMID: 33956813

A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction. Guirado Guillen R, Perez-Rando M, Ferragud A, Gutierrez-Castellanos N, Umemori J, Carceller Cerda H, Nacher Roselló J, Castillo-Gomez E. Frontiers in Behavioral Neuroscience. 2020 Apr 7;14:51. doi: 10.3389/fnbeh.2020.00051. PMID: 32317945

A replication study of JTC bias, genetic liability for psychosis and delusional ideation. Henquet C, van Os J, Pries L, Rauschenberg C, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan Arias J, Aguilar Garcia Iturrospe E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O’Donovan M, Rutten B, Guloksuz S. Psychological Medicine. 2020 Oct 13;1-7. doi: 10.1017/S0033291720003578. PMID: 33046166

Antioxidant Therapies and Oxidative Stress in Friedreichs Ataxia: The Right Path or Just a Diversion?. Rodriguez Melguizo L, Lapeña Luzón T, Calap Quintana P, Moltó Ruiz M, González Cabo P, Navarro Langa J. Antioxidants (Basel, Switzerland). 2020 Jul 24;9(8):664. doi: 10.3390/antiox9080664. PMID: 32722309

Association study of candidate genes with obesity and metabolic traits in antipsychotic-treated patients with first-episode psychosis over a 2-year period. Gasso P, Albert Arnaiz J, Mas S, Lafuente A, Bioque M, Cuesta M, Diaz-Caneja C, Garcia C, Lobo A, Gonzalez-Pinto A, Parellada M, Corripio I, Vieta E, Castro-Fornieles J, Mane A, Rodriguez N, Bolac D, Saiz-Ruiz J, Bernardo M, Mezquida G, Amoretti S, Pina-Camacho L, Gonzalez-Penas J, Alonso-Solis A, Rabetla M, Zorrilla I, Garcia S, Barcones F, Modrego P, Sanjuan Arias J, Nacher Roselló J, Berge D, Monserrat C, Verdolini N, Gil-Badenes J, Baeza I, De La Serna E, Contreras F, Saiz-Masvidal C, Paz Garcia-Portilla M, Bobes J, Gutierrez M, Segarra R, Dompablo M, Rodriguez-Jimenez R, Usall J, Butjosa A, Sarro S, Pomarol-Clotet E, Ibanez A, Ribeiro M, SELVA VERA G, PEPs Grp. Journal of Psychopharmacology. 2020 May;34(5):514-523. doi: 10.1177/0269881120903462. PMID: 32009515

Birth weight and antipsychotic induced weight gain: A prenatal programming approach in the PEPs study. Garcia-Rizo C, Bioque M, Mezquida G, Amoretti S, Cuesta M, Diaz-Caneja C, Mas S, Lobo A, Gonzalez-Pinto A, Fraguas D, Corripio I, Vieta E, Baeza I, Berge D, Fernandez-Egea E, Garriga M, Bernardo M, Sanjuan Arias J, PEPs group. Schizophrenia Research. 2020 Apr;218:292-294. doi: 10.1016/j.schres.2019.12.030. PMID: 32001078

Cognitive Insight in First-Episode Psychosis: Changes during Metacognitive Training. Birules I, Lopez-Carrilero R, Cuadras D, Pousa E, Barrigon M, Barajas A, Lorente Rovira E, Gonzalez-Higueras F, Grasa E, Ruiz-Delgado I, Cid J, de Apraiz A, Montserrat R, Pelaez T, Moritz S, The Spanish Metacognition Study Group, Ochoa S. Journal of Personalized Medicine. 2020 Nov 27;10(4):253. doi: 10.3390/jpm10040253. PMID: 33260823

Cognitive-behavioural group therapy for insomnia: evaluation of the results after its implementation in a health department. De Entrambasaguas Barretto M, Mika Aiko, Luciano E, Dominguez Cabañero E, Terrés Jiménez B, Diego Castaño S, Gonzalez Vivas C, Garcia Pareño B, Lorente Rovira E, Herraiz Llongo B, Victorio Muñoz R, Cases Bergon P. Revista de Neurologia. 2020 Apr 1;70(7):246-250. doi: 10.33588/rn.7007.2019385. PMID: 32182371

Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients: the EU-GEI case-control study. Quattrone D, Ferraro L, Tripoli G, La Cascia C, Quigley H, Quattrone A, Jongsma H, Del Peschio S, Gatto G, Gayer-Anderson C, Jones P, Kirkbride J, La Barbera D, Tarricone I, Berardi D, Tosato S, Lasalvia A, Szoke A, Arango C, Bernardo M, Bobes J, Del Ben C, Menezes P, Llorca P, Santos J, Sanjuan Arias J, Tortelli A, Velthorst E, de Haan L, Rutten B, Lynskey M, Freeman T, Sham P, Cardno A, Vassos E, van Os J, Morgan C, Reininghaus U, Lewis C, Murray R, Di Forti M, EU-GEI group. Psychological Medicine. 2020 Mar 18;51(8):1-9. doi: 10.1017/S0033291720000082. PMID: 32183927

Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood. Carceller H, Guirado Guillen R, Nacher Roselló J. Journal of Comparative Neurology. 2020 Jun;528(8):1349-1366. doi: 10.1002/cne.24832. PMID: 31792992

Delta-9-Tetrahydrocannabinol treatment during adolescence and alterations in the inhibitory networks of the adult prefrontal cortex in mice subjected to perinatal NMDA receptor antagonist injection and to postweaning social isolation. Garcia-Mompo C, Curto Y, Carceller H, Gilabert Juan J, Rodriguez-Flores E, Guirado Guillen R, Nacher Roselló J. Translational Psychiatry. 2020 Jun 1;10(1):177. doi: 10.1038/s41398-020-0853-3. PMID: 32488050

Different measures for auditory hallucinations in populations with psychosis. The Validation of the Spanish versions of the Auditory Vocal Hallucination Rating Scale (AVHRS) and the Positive and Useful Voices Inquiry (PUVI). Lorente Rovira E, Grasa E, Ochoa S, Corripio I, Pelaez T, Lopez-Carrilero R, Gutierrez-Gea A, Morano-Guillen M, Villagran J, Bartels-Velthuis A, Jenner J, Sanjuan Arias J. Revista de Psiquiatria y Salud Mental. 2020 May 31;S1888-9891(20)30027-6. doi: 10.1016/j.rpsm.2020.03.002. PMID: 32493672

Effects of a single session of SMR neurofeedback training on anxiety and cortisol levels. Gadea Domenech M, Alino M, Hidalgo V, Espert Tortajada R, Salvador A. Neurophysiologie Clinique. 2020 Jul;50(3):167-173. doi: 10.1016/j.neucli.2020.03.001. PMID: 32279927

Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex. Coviello S, Gramuntell Y, Castillo-Gomez E, NacherJ. Frontiers in Neuroscience. 2020 Oct 6;14:574234. doi: 10.3389/fnins.2020.574234. PMID: 33122993

Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness. Berge D, Mane A, Lesh T, Bioque M, Barcones F, Gonzalez-Pinto A, Parellada M, Vieta E, Castro-Fornieles J, Rodriguez-Jimenez R, Garcia-Portilla M, Usall J, Carter C, Cabrera B, Bernardo M, Janssen J, Sanjuan Arias J, PEPs group (collaborators). Schizophrenia Bulletin. 2020 Jul 8;46(4):846-856. doi: 10.1093/schbul/sbz132. PMID: 31915835

Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. van Os J, Pries L, Ten Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan Arias J, Aguilar Garcia Iturrospe E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O’Donovan M, Rutten B, Guloksuz S. Psychological Medicine. 2020 Oct 19;1-13. doi: 10.1017/S0033291720003748. PMID: 33070791

Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum. Pries L, Dal Ferro G, van Os J, Delespaul P, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Sahin Cankurtaran E, Ulusoy Kaymak S, Mihaljevic M, Andric Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan Arias J, Aguilar Garcia Iturrospe E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Can Saka M, Arango C, O’Donovan M, Tosato S, Rutten B, Guloksuz S, Genetic Risk Outcome Psychosis GRP. Epidemiology and Psychiatric Sciences. 2020 Nov 17;29:e182. doi: 10.1017/S2045796020000943. PMID: 33200977

First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm. Gonzalez-Vivas C, Garcia-Marti G, Soldevila-Matias P, Sanz-Requena R, Aguilar E, Castro-Bleda M, Marti-Bonmati L, Sanjuan J. Frontiers in Psychiatry. 2020 Dec 11;11:593042. doi: 10.3389/fpsyt.2020.593042. PMID: 33424663

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Wakhloo D, Scharkowski F, Curto Y, Javed Butt U, Bansal V, Steixner-Kumar A, Wustefeld L, Rajput A, Arinrad S, Zillmann M, Seelbach A, Hassouna I, Schneider K, Qadir Ibrahim A, Werner H, Martens H, Miskowiak K, Wojcik S, Bonn S, Nacher Roselló J, Nave K, Ehrenreich H. Nature Communications. 2020 Mar 9;11(1):1313. doi: 10.1038/s41467-020-15041-1. PMID: 32734433

Functional Integration of Neuronal Precursors in the Adult Murine Piriform Cortex. Benedetti B, Dannehl D, Konig R, Coviello S, Kreutzer C, Zaunmair P, Jakubecova D, Weiger T, Aigner L, Nacher Roselló J, Engelhardt M, Couillard-Despres S. Cerebral Cortex. 2020 Mar 14;30(3):1499-1515. doi: 10.1093/cercor/bhz181 PMID: 31647533

Gender differences in response to metacognitive training in people with first-episode psychosis. Salas-Sender M, Lopez-Carrilero R, Barajas A, Lorente Rovira E, Pousa E, Barrigon M, Grasa E, Ruiz-Delgado I, Gonzalez-Higueras F, Cid J, Aznar A, Pelaez T, Birules I, Moritz S, The Spanish Metacognition Study Group, Ochoa S. Journal Of Consulting And Clinical Psychology. 2020 Jun;88(6):516-525. doi: 10.1037/ccp0000468. PMID: 31855037

How our gaze reacts to another person’s tears? experimental insights into eye tracking technology. Pico A, Espert Tortajada R, Gadea Domenech M. Frontiers in Psychology. 2020 Sep 2;11:2134. doi: 10.3389/fpsyg.2020.02134. PMID: 32982872

Interaction between the functional SNP rs2070951 in NR3C2 gene and high levels of plasma corticotropin-releasing hormone associates to postpartum depression. Gutierrez-Zotes A, Diaz-Pena R, Costas J, Martorell L, Gelabert E, Sans T, Navines R, Albacar G, Imaz M, Garcia-Esteve L, Sanjuan Arias J, Martin-Santos R, Carracedo A, Vilella E. Archives Of Womens Mental Health. 2020 Jun;23(3):413-420. doi: 10.1007/s00737-019-00989-x. PMID: 31388769

MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes. Albert-Gasco H, Ros-Bernal F, Castillo-Gomez E, Olucha Bordonau F. International Journal of Molecular Sciences. 2020 Jun 23;21(12):4471. doi: 10.3390/ijms21124471. PMID: 32586047

Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and gamma Activity in the Prefrontal Cortex. Carceller H, Guirado Guillen R, Ripolles-Campos E, Teruel-Marti V, Nacher Roselló J. The Journal of Neuroscience. 2020 Jun 24;40(26):5008-5018. doi: 10.1523/JNEUROSCI.0291-20.2020. PMID: 32457072

Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first-episode psychosis cohort. Mas S, Gasso P, Rodriguez N, Cabrera B, Mezquida G, Lobo A, Gonzalez-Pinto A, Parellada M, Corripio I, Vieta E, Castro-Fornieles J, Bobes J, Usall J, Saiz-Ruiz J, Contreras F, Parellada E, Bernardo M, Lafuente A, Bioque M, Diaz-Caneja C, Gonzalez-Penas J, Solis A, Rebella M, Gonzalez-Ortega I, Besga A, Sanjuan Arias J, Nacher Roselló J, Morro L, Montserrat C, Jimenez E, Gomes Da Costa S, Baeza I, de la Serna E, Rivas S, Diaz C, Saiz P, Garcia-Alvarez L, Gutierrez Fraile M, Zabala Rabadan A, Torio I, Rodriguez-Jimenez R, Butjosa A, Pardo M, Sarro S, Pomarol-Clotet E, Ibanez Cuadrado A, Cuesta M, PEPs Grp. Acta Psychiatrica Scandinavica. 2020 Jun;141(6):541-552. doi: 10.1111/acps.13131. PMID: 31746462

Phenotypic characterization of MCP-1 expressing neurons in the rat cerebral cortex. Mulet M, Blasco-Ibanez J, Kirstein M, Crespo C, Nacher Roselló J, Varea E. Journal Of Chemical Neuroanatomy. 2020 Jul;106:101785. doi: 10.1016/j.jchemneu.2020.101785. PMID: 32205215

Piriform cortex alterations in the Ts65Dn model for down síndrome. Carbonell J, Blasco Ibanez JM, Crespo C, Nacher J, Varea E. Brain Research. 2020 Nov 15;1747:147031. doi: 10.1016/j.brainres.2020.147031. PMID: 32726601

Positive and Useful Voices in Patients With Schizophrenia: Prevalence, Course, Characteristics, and Correlates. Lorente Rovira E, Grasa E, Ochoa S, Corripio I, Pelaez T, Lopez-Carrillero R, Morano-Guillen M, Gutierrez-Gea A, Villagran J, Llacer B, Sanjuan Arias J. The Journal of nervous and mental disease. 2020 Aug;208(8):587-592. PMID: 32453282

Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies. Soldevila Matias P, Albajes-Eizagirre A, Radua J, Garcia Marti G, Rubio J, Tordesillas-Gutierrez D, Fuentes Dura I, Solanes A, Fortea L, Oliver D, Sanjuan Arias J. Revista de Psiquiatria y Salud Mental. 2020 Sep 25;S1888-9891(20)30100-2. doi: 10.1016/j.rpsm.2020.08.001. PMID: 32988773

Premorbid Adjustment and IQ in Patients With First-Episode Psychosis: A Multisite Case-Control Study of Their Relationship With Cannabis Use. Ferraro L, La Cascia C, Quattrone D, Sideli L, Matranga D, Capuccio V, Tripoli G, Gayer-Anderson C, Morgan C, Sami M, Sham P, de Haan L, Velthorst E, Jongsma H, Kirkbride J, Rutten B, Richards A, Roldan L, Arango C, Bernardo M, Bobes J, Sanjuan Arias J, Santos J, Arrojo M, Tarricone I, Tortelli A, Szoke A, Del-Ben C, Selten J, Lynskey M, Jones P, Van Os J, La Barbera D, Murray R, Di Forti M, WP2 EU-GEI GROUP. Schizophrenia Bulletin.2020 Apr 10;46(3):517-529. doi: 10.1093/schbul/sbz077. PMID: 31361020

Psychotic Experiences Are Associated With Paternal Age But Not With Delayed Fatherhood in a Large, Multinational, Community Sample. Schurhoff F, Pignon B, Lajnef M, Denis R, Rutten B, Morgan C, Murray R, Leboyer M, van Os J, Szoke A, Sanjuan Arias J, EU-GEI WP2. Schizophrenia Bulletin. 2020 Feb 12;46(5):1327-1334. doi: 10.1093/schbul/sbz142. PMID: 32049353

Pulmonary thromboembolism associated with the use of new antipsychotics in a paediatric patient. Alvarez Bravos L, Muñoz Bonet J, Flor Macian E, Aguilar Garcia Iturrospe E. Journal of Paediatrics and Child Health. 2020 Sep;56(9):1473-1474. doi: 10.1111/jpc.15083. PMID: 32949212

ReMindCare App for Early Psychosis: Pragmatic Real World Intervention and Usability Study. BONET MORA L, Torous J, Arce D, Blanquer I, Sanjuan Arias J. JMIR mHealth and uHealth. 2020 Nov 6;8(11):e22997. doi: 10.2196/22997. PMID: 33155986

Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study. van Os J, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran EŞ, Kaymak SU, Mihaljevic MM, Petrovic SA, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz PA, García-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric NP, Atbaşoğlu C, Ucok A, Alptekin K, Saka MC; Genetic Risk and Outcome Investigators (GROUP), Arango C, O’Donovan M, Rutten BPF, Guloksuz S. Psychological Medicine. 2020 Aug;50(11):1884-1897. doi: 10.1017/S003329171900196X. PMID: 31414981

Semilunar Granule Cells Are the Primary Source of the Perisomatic Excitatory Innervation Onto Parvalbumin-Expressing Interneurons in the Dentate Gyrus. Rovira-Esteban L, Hájos N, Attila Nagy G, Crespo C, Nacher J, Varea E, Blasco-Ibáñez JM. eNeuro. 2020 Jul 7;7(4):ENEURO.0323-19.2020. doi: 10.1523/ENEURO.0323-19.2020. PMID: 32571963

Substance use during pregnancy and personality dimensions. Imaz M, Navines R, Gelabert E, Fonseca F, Gutierrez-Zotes A, Guillamat R, Langohr K, Canellas F, Gornemann I, Costas J, Mayoral F, Valles V, De Diego Y, Roca M, Iborra J, Gratacos M, Vilella E, Garcia-Esteve L, Sanjuan Arias J, Torrens M, Martin-Santos Laffon R. Adicciones. 2020 Dec 2;0(0):1433. doi: 10.20882/adicciones.1433. PMID: 3338243

Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau sedes. Perez Rando M, Dujardin S, Bennett R, Commins C, Nibhanupudy T, Hyman B. Acta Neuropathologica Communications. 2020 Oct 19;8(1):168. doi: 10.1186/s40478-020-01049-7. PMID: 33076986

Tau reduction in aged mice does not impact Microangiopathy. Bennett R, Hu M, Fernandes A, Perez Rando M, Robbins A, Kamath T, Dujardin S, Hyman B. Acta Neuropathologica Communications. 2020 Aug 18;8(1):137. doi: 10.1186/s40478-020-01014-4. PMID: 32811565

The Challenge of Introducing Competency-Based Psychiatry Training in Spain. Etxeandia Pradera J, Martinez-Uribe D, Bellver Pradas F, Gonzalez Piqueras J, Aguilar Garcia Iturrospe E. Academic Psychiatry. 2020 Dec;44(6):770-774. doi: 10.1007/s40596-020-01221-0. PMID: 32266680

The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme. Gayer-Anderson C, Jongsma H, Di Forti M, Quattrone D, Velthorst E, de Haan L, Selten J, Szoke A, Llorca P, Tortelli A, Arango C, Bobes J, Bernardo M, Sanjuan J, Santos J, Arrojo M, Parellada M, Tarricone I, Berardi D, Ruggeri M, Lasalvia A, Ferraro L, La Cascia C, La Barbera D, Menezes P, Del-Ben C, Rutten B, van Os J, Jones P, Murray R, Kirkbride J, Morgan C, Moltó Ruiz M, EU-GEI WP2 Grp. Social Psychiatry and Psychiatric Epidemiology. 2020 May;55(5):645-657. doi: 10.1007/s00127-020-01831-x. PMID: 31974809

The incidence of psychotic disorders among migrants and minority ethnic groups in Europe: findings from the multinational EU-GEI study. Termorshuizen F, van der Ven E, Tarricone I, Jongsma H, Gayer-Anderson C, Lasalvia A, Tosato S, Quattrone D, La Cascia C, Szoke A, Berardi D, Llorca P, de Haan L, Velthorst E, Bernardo M, Sanjuan Arias J, Arrojo M, Murray R, Rutten B, Jones P, van Os J, Kirkbride J, Morgan C, Selten J. Psychological Medicine. 2020 Sep 22;1-10. doi: 10.1017/S0033291720003219. PMID: 32958094

The role of imaging biomarkers in the assessment of sarcopenia. Sanz-Requena R, Miguel Martinez-Arnau F, Pablos-Monzo A, Flor-Rufino C, Barrachina-Igual J, Garcia Marti G, Marti-Bonmati L, Perez-Ros P. Diagnostics. 2020 Jul 30;10(8):534. doi: 10.3390/diagnostics10080534. PMID: 32751452

The role of personality dimensions, depressive symptoms and other psychosocial variables in predicting postpartum suicidal ideation: a cohort study. Gelabert E, Gutierrez-Zotes A, Navines R, Labad J, Puyane M, Donadon M, Guillamat R, Mayoral F, Jover M, Canellas F, Gratacos M, Guitart M, Gornemann I, Roca M, Costas J, Llacer Iborra B, Subira S, de Diego Y, Osorio F, Garcia-Esteve L, Sanjuan Arias J, Vilella E, Martin-Santos R. Archives of Womens Mental Health. 2020 Aug;23(4):585-593. doi: 10.1007/s00737-019-01007-w. PMID: 31802248

Transcranial direct current stimulation and speech therapy intervention in people with aphasia: a systematic review of the literatura. Corrales-Quispiricra C, Gadea Domenech M, Espert Tortajada R. Revista de Neurologia. 2020 May 16;70(10):351-364. doi: 10.33588/rn.7010.2019397. PMID: 32390128

Proyectos
Referencia: INVEST/2022/141
Título: Programa de formación y ocupabilidad de psicologo/a en evaluaciones clínicas y uso seguimiento del aplicativo remindcare en proyectos de investigación
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: Julio Sanjuan Arias
Duración: 2023 – 2024
Presupuesto: 66.218 €

Referencia: INVEST/2022/49
Título: Programa de formación y ocupabilidad de especialista en analisis de imagen de sistema nervioso
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: Juan Nácher Roselló
Duración: 2023 – 2024
Presupuesto: 66.218 €

Referencia: PI20/00473
Título: Estudio longitudinal de una cohorte representativa: superando la heterogeneidad clínica y biológica en primeros episodios psicóticos
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Julio Sanjuán Arias
Duración: 2021 – 2023
Presupuesto: 68.970 €

Referencia: PROMETEO/2020/024
Título: Estudio longitudinal de una cohorte representativa: superando la heterogeneidad clínica y biológica en primeros episodios psicóticos
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: Julio Sanjuán Arias
Duración: 2020 – 2023
Presupuesto: 174.588 €

Referencia: RTI2018-098269-B-I00
Título: La matriz extracelular cerebral en la depresión: de modelos animales a pacientes
Entidad Financiadora: Ministerio de Ciencia e Innovación
Investigador principal: Juan Salvador Nacher Roselló
Duración: 2019 – 2021
Presupuesto: 217.800 €

Referencia: PI17/00402
Título: Resonancia magnética funcional y expresión génica como predictores en primeros episodios psicóticos
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Julio Sanjuán Arias
Duración: 2018 – 2020
Presupuesto: 110.231 €

Referencia: PROMETEO/2016/082
Título: Investigación de marcadores biológicos y nuevas estrategias terapéuticas en la Psicosis
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Julio Sanjuán Arias
Duración: 2016 – 2019
Presupuesto: 179.940 €

Referencia: SAF2015-68436-R
Título: Plasticity of perisomatic inhibition on pyramidal neurons of the prefrontal cortex: impact of peripubertal stress and implication in psychiatric disorder
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Juan Salvador Nacher Roselló
Duración: 2016 – 2019
Presupuesto: 193.600 €

Referencia: CB07/09/0006
Título: CIBER de Salud Mental (CIBERSAM)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Julio Sanjuán Arias
Duración: 2008 –
Presupuesto:

+ Información
Título: Study of the population of immature neurons in the adult piriform cortex layer ii
Doctorando: Belles Esteller, María
Director: Nácher Roselló, Juan Salvador; Castillo Gómez, Esther
Fecha: 18/01/2019
Universidad: Universitat de València

Título: Analysis of structural plasticity in the adult and adolescent mouse brain. Effects of erythropoietin
Doctorando: Curto Sastre, Yasmina
Director: Nácher Roselló, Juan Salvador
Fecha: 08/07/2019
Universidad: Universitat de València

Título: Resonancia magnética funcional con paradigma emocional en pacientes con un primer episodio psicótico
Doctorando: Soldevila Matías, Pablo
Director: Sanjuan Arias, Julio; Espert Tortajada, Raúl; García Martí, Gracián
Fecha: 28/11/2019
Universidad: Universitat de València

Título: El impacto de la fibromialgia en el núcleo familiar en un departamento de la Comunidad Valenciana
Doctorando: Vázquez Canales, Luz de Myotanh
Director: Aguilar García Iturrospe, Eduardo Jesús; Pereiró Berenguer, Inmaculada
Fecha: 10/01/2020
Universidad: Universitat de València

Título: Induction of neuronal plasticity during adulthood. Role of cortical interneurons and plasticity-related molecules
Doctorando: Carceller Cerdá, Héctor
Director: Guirado Guillén, Ramón; Nácher Roselló, Juan Salvador
Fecha: 28/02/2020
Universidad: Universitat de València

Título: Estudio de la plasticidad estructural en enfermedades psiquiátricas con modelos animales
Doctorando: Bueno Fernández, Clara
Director: Nacher Rosello, Juan Salvador; Castillo Gómez, Esther
Fecha: 09/03/2021
Universidad: Universitat de València

Título: Papel de núcleo incertus en el reconocimiento social a través de sus conexiones en el cerebro de rata
Doctorando: García Díaz, Cristina
Director: Olucha Bordonau, Francisco
Fecha: 29/03/2021
Universidad: Universidad Jaume I de Castellón

Título: Continuous Neuronal Integration in the Cerebral Cortex of Rodents and Humans
Doctorando: Coviello, Simona
Director: Nácher Roselló, Juan Salvador; Castillo Gómez, Esther
Fecha: 30/03/2021
Universidad: Universitat de València

Título: Eficacia de un programa de rehabilitación de las funciones atencionales mediante tareas competitivas multijugador. Estudio clínico, neurofisiológico y neuroanatómico en pacientes con ictus
Doctorando: Navarro Pérez, Mª Dolores
Director: Lloréns Rodríguez, Roberto; Gadea Domènech, Maria Engracia; Noe Sebastián, Enrique
Fecha: 25/05/2021
Universidad: Universitat de València

Título: REMINDCARE: una aplicación para primeros episodios psicóticos integrada en la práctica clínica diaria
Doctorando: Bonet Mora, Lucía
Director: Sanjuán Arias, Julio   
Fecha: 16/07/2021
Universidad: Universitat de València

Título: Tears as powerful visual communication signals: a sociobiological approach
Doctorando: Picó Peris, Alfonso Ignacio
Director: Gadea Domènech, Maria Engracia
Fecha: 13/07/2021
Universidad: Universitat de València

Título: Hospitalización Domiciliaria en Salud Mental: eficacia y viabilidad
Doctorando: Ferrando Aparicio, Elvira
Director: Aguilar García Iturrospe, Eduardo Jesús; Silvestre Pascual, Francisca
Fecha: 07/07/2021
Universidad: Universitat de València