Grupo de Investigación en Medicina Reproductiva

Área de Medicina Reproductiva

Nuestra actividad involucra predominantemente la investigación en el campo de la Medicina Reproductiva, con especial énfasis en los campos de la medicina regenerativa relacionados con el endometrio y estudios genómicos sobre la viabilidad embrionaria y la receptividad endometrial, así como otros factores causantes de infertilidad

Uno de nuestros objetivos es la caracterización de la resolución unicelular del útero humano, que proporcionará una visión sin precedentes de los cambios transcriptómicos, genómicos y espaciales de este importante órgano femenino no solo a lo largo del ciclo menstrual sino también a lo largo de la vida. La comparación en condiciones sanas y enfermas también está en el alcance

Coordinador
Dr. Carlos Simón Vallés
carlos.simon@uv.es

INVESTIGADORES
R4 Senior

Carlos Simón Vallés    

R3 Consolidado

David Blesa Jarque

R2 Novel / Emergente

Antonio Díez Juan
Beatriz Rosón Burgo
Carlos Lozano Asencio
Carmen García Pascual
Carmen Rubio Lluesa
Diana Valbuena Perilla
Inmaculada Moreno Gimeno
Miguel Milán Sánchez
Nandakumar Venkatesan
Tamara Garrido Gómez
Aymara Mas Perucho    

R1 Predoctoral

Alba Machado López
Claudia Abellán Orihuela
Irene Muñoz Blat
Nerea Castillo Marco

STAFF
Colaborador/a
Enfermero/a
Técnico/a

Marta Gálvez Diezma
Marta González Monfort
Roberto Alonso Valero

Apoyo
Publicaciones
BRCA, breast cancer and in vitro fertilization: how should we advise our patients?. Garcia-Planells J, Frances B, Diez-Juan A. Fertility and Sterility. 2021 Aug;116(2):359-360. doi: 10.1016/j.fertnstert.2021.06.011. PMID: 34247761

Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population. Capalbo A, Fabiani M, Caroselli S, Poli M, Girardi L, Patassini C, Favero F, Cimadomo D, Vaiarelli A, Simon C, Rienzi LF, Ubaldi FM. Human Reproduction. 2021 May 22:deab087. doi: 10.1093/humrep/deab087. PMID: 34021342

Consensus vision. Simon C. Fertility and Sterility. 2021 Jul;116(1):13-14. doi: 10.1016/j.fertnstert.2021.05.090. PMID: 34148581

Darwin meets Mendel in the reproductive medicine field: Homo sapiens 2.0 is inevitable. O’Brien J, Adashi E, Simon C. Fertility and Sterility. 2021 Feb 25;S0015-0282(21)00079-0. doi: 10.1016/j.fertnstert.2021.01.047. PMID: 33642062

Embryo Genetics. Rubio C, Simon C. Genes. 2021 Jan 19;12(1):118. doi: 10.3390/genes12010118. PMID: 33477974

Endometrial factor in unexplained infertility and recurrent implantation failure. Santamaria X, Simon C. Seminars in Reproductive Medicine. 2021 Aug 23. doi: 10.1055/s-0041-1735199. PMID: 34425598

Invitro fertilization and andrology laboratories in 2030. Simon C, Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L. Fertility and Sterility. 2021 Jul;116(1):2-3. doi: 10.1016/j.fertnstert.2021.05.089. PMID: 34148585

Invitro fertilization and andrology laboratory in 2030: expert visions. Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L, Simon C. Fertility and Sterility. 2021 Jul;116(1):4-12. doi: 10.1016/j.fertnstert.2021.05.088. PMID: 34148588

Molecular and cellular insights into the development of uterine fibroids. Machado-Lopez A, Simon C, Mas A. International Journal of Molecular Sciences. 2021 Aug 6;22(16):8483. doi: 10.3390/ijms22168483. PMID: 34445194

Noninvasive preimplantation genetic testing for aneuploidy in spent blastocyst media will substitute for trophectoderm biopsy. Simon C. Fertility and sterility. 2021 Mar 13;S0015-0282(21)00170-9. doi: 10.1016/j.fertnstert.2021.02.046. PMID: 33726897

Noninvasive preimplantation genetic testing for aneuploidy in spent culture medium as a substitute for trophectoderm biopsy. Rubio C, Racowsky C, Barad D, Scott R, Simon C. Fertility and Sterility. 2021 Mar 16;S0015-0282(21)00169-2. doi: 10.1016/j.fertnstert.2021.02.045. PMID: 33741125

Noninvasive preimplantation genetic testing for aneuploidy: is the glass half-empty or half-full?. Rubio C, Simon C. Fertility and Sterility. 2021 Jun;115(6):1426-1427. doi: 10.1016/j.fertnstert.2021.04.002. PMID: 34053511

Obesity affects endometrial receptivity by displacing the window of implantation. Bellver J, Marin C, Lathi RB, Murugappan G, Labarta E, Vidal C, Giles J, Cabanillas S, Marzal A, Galliano D, Ruiz-Alonso M, Simon C, Valbuena D. Reproductive Sciences. 2021 May 25. doi: 10.1007/s43032-021-00631-1. PMID: 34033112

Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data. Capalbo A, Poli M, Riera-Escamilla A, Shukla V, Kudo Hoffding M, Krausz C, Hoffmann E, Simon Valles C. Human Reproduction Update. 2021 Feb 19;27(2):254-279. doi: 10.1093/humupd/dmaa044. PMID: 33197264

SARS-CoV-2 immunity, infective and naïve incidence in fertility clinics after lockdown. Foulk R, Sakkas D, Kayali R, Valbuena D, Simon C, Cuzzi J. American Journal of Obstetrics and Gynecology. 2021 Mar 11;S0002-9378(21)00159-9. doi: 10.1016/j.ajog.2021.03.008. PMID: 33716073

Single-cell RNA Sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium. Vilella F, Wang W, Moreno I, Roson B, Quake S, Simon C. Human Reproduction. 2021 Jul 30;deab183. doi: 10.1093/humrep/deab183. PMID: 34329437

Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility. Garrido N, Cruz F, Egea R, Simon C, Sadler-Riggleman I, Beck D, Nilsson E, Ben Maamar M, Skinner M. Clinical Epigenetics. 2021 Jan 7;13(1):6. doi: 10.1186/s13148-020-00995-2. PMID: 33413568

The impact of patient, embryo, and translocation characteristics on the ploidy status of young couples undergoing preimplantation genetic testing for structural rearrangements (PGT-SR) by next generation sequencing (NGS). Boynukalin F, Gultomruk M, Turgut N, Rubio C, Rodrigo L, Yarkiner Z, Ecemis S, Karlikaya G, Findikli N, Bahceci M. Journal of Assisted Reproduction and Genetics. 2021 Feb;38(2):387-396. doi: 10.1007/s10815-020-02054-4. PMID: 33398513

The morphokinetic signature of mosaic embryos: evidence in support of their own genetic identity. Martin A, Rodrigo L, Beltran D, Meseguer M, Rubio C, Mercader A, de Los Santos MJ. Fertility and Sterility. 2021 Jul;116(1):165-173. doi: 10.1016/j.fertnstert.2020.12.031. PMID: 33766460

Understanding the human endometrium in the 21st century. Vilella F, Wang W, Moreno I, Quake SR, Simon C. American Journal of Obstetrics and Gynecology. 2021 May 19;S0002-9378(21)00453-1. doi: 10.1016/j.ajog.2021.04.224. PMID: 34023092

A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF. Simon Valles C, Gomez C, Cabanillas S, Vladimirov I, Castillon G, Giles Jimenez J, Boynukalin K, Findikli N, Bahceci M, Ortega I, Vidal C, Funabiki M, Izquierdo A, Lopez L, Portela S, Frantz N, Kulmann M, Taguchi S, Labarta E, Colucci F, Mackens S, Santamaria X, Munoz E, Barrera S, Garcia-Velasco J, Fernandez M, Ferrando M, Ruiz M, Mol B, Valbuena Parilla D, Era-Rct Study Consortium Group. Reproductive Biomedicine Online. 2020 Sep;41(3):402-415. doi: 10.1016/j.rbmo.2020.06.002. PMID: 32723696

Bacterial Vaginosis and Its Association with Infertility, Endometritis, and Pelvic Inflammatory Disease. Ravel J, Moreno Gimeno I, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Oct 19;S0002-9378(20)31193-5. doi: 10.1016/j.ajog.2020.10.019. PMID: 33091407

beta-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation. Danek P, Kardosova M, Janeckova L, Karkoulia E, Vanickova K, Fabisik M, Lozano-Asencio C, Benoukraf T, Tirado-Magallanes R, Zhou Q, Burocziova M, Rahmatova S, Pytlik R, Brdicka T, Tenen D, Korinek V, Alberich-Jorda M. Blood. 2020 Nov 26;136(22):2574-2587. doi: 10.1182/blood.2019004664. PMID: 32822472

Characteristics of the IVF Cycle that Contribute to the Incidence of Mosaicism. Rodrigo L, Clemente-Ciscar M, Campos-Galindo I, Peinado V, Simon Valles C, Rubio Lluesa C. Genes. 2020 Sep 30;11(10):1151. doi: 10.3390/genes11101151. PMID: 33007801

Combined Preimplantation Genetic Testing for Autosomal Dominant Polycystic Kidney Disease: Consequences for Embryos Available for Transfer. Mir Pardo P, Martinez-Conejero J, Martin J, Simon Valles C, Cervero A. Genes. 2020 Jun 24;11(6):692. doi: 10.3390/genes11060692. PMID: 32599795

Decidualization resistance in the origin of preeclampsia. Garrido Gomez T, Castillo Marco N, Cordero T, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Sep 29;S0002-9378(20)31130-3. doi: 10.1016/j.ajog.2020.09.039. PMID: 33007270

Endometrial Decidualization: The Primary Driver of Pregnancy Health. Ng S, Norwitz G, Pavlicev M, Tilburgs T, Simon Valles C, Norwitz E. International Journal of Molecular Sciences. 2020 Jun 8;21(11):4092. doi: 10.3390/ijms21114092. PMID: 32521725

Endometrial liquid biopsy provides a miRNA roadmap of the secretory phase of the human endometrium. Grasso A, Navarro R, Balaguer Cuenca N, Moreno Gimeno I, Alama P, Jimenez J, Simon Valles C, Vilella Mitjana F. Journal of Clinical Endocrinology & Metabolism. 2020 Mar 1;105(3):dgz146. doi: 10.1210/clinem/dgz146. PMID: 31665361

Identification and Characterization of Extracellular Vesicles and Its DNA Cargo Secreted During Murine Embryo Development. Simon B, Bolumar Recuero D, Amadoz A, Jiménez Almazán J, Valbuena Parilla D, Vilella Mitjana F, Moreno Gimeno I. Genes. 2020 Feb 17;11(2):203. doi: 10.3390/genes11020203. PMID: 32079252

Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos. Girardi L, Serdarogullari M, Patassini C, Poli M, Fabiani M, Caroselli S, Coban O, Findikli N, Boynukalin F, Bahceci M, Chopra R, Canipari R, Cimadomo D, Rienzi L, Ubaldi F, Hoffmann E, Rubio Lluesa C, Simon Valles C, Capalbo A. American Journal of Human Genetics. 2020 Apr 2;106(4):525-534. doi: 10.1016/j.ajhg.2020.03.005. PMID: 32220293

Introduction: How evident is the evidence?. Simon C. Fertility and Sterility. 2020 Jul 2;S0015-0282(20)30350-2. doi: 10.1016/j.fertnstert.2020.04.022. PMID: 32624212

Introduction: How evident is the evidence?. Simon Valles C. Fertility and Sterility. 2020 Jun;113(6):1091-1092. doi: 10.1016/j.fertnstert.2020.03.018. PMID: 32482243

Menstruation: science and society. Critchley H, Babayev E, Bulun S, Clark S, Garcia-Grau I, Gregersen P, Kilcoyne A, Kim J, Lavender M, Marsh E, Matteson K, Maybin J, Metz C, Moreno I, Silk K, Sommer M, Simon C, Tariyal R, Taylor H, Wagner G, Griffith L. American Journal of Obstetrics and Gynecology. 2020 Nov;223(5):624-664. doi: 10.1016/j.ajog.2020.06.004. PMID: 32707266

Multicenter prospective study of concordance between embryo cell-free DNA and trophectoderm biopsies from 1,301 human blastocysts. Rubio Lluesa C, Navarro-Sanchez L, Garcia-Pascual C, Ocali O, Cimadomo D, Venier W, Barroso G, Kopcow L, Bahceci M, Roos Kulmann M, Lopez L, De La Fuente E, Navarro R, Valbuena Parilla D, Sakkas D, Rienzi L, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Nov;223(5):751.e1-751.e13. doi: 10.1016/j.ajog.2020.04.035. PMID: 32470458

Operative hysteroscopy should be repeated as many times as necessary for the treatment of refractory Asherman syndrome versus is there any alternative therapy worth considering?. Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):510. doi: 10.1016/j.fertnstert.2020.01.021. PMID: 32089254

Optimized NGS Approach for Detection of Aneuploidies and Mosaicism in PGT-A and Imbalances in PGT-SR. Garcia-Pascual C, Navarro-Sanchez L, Navarro R, Martinez L, Jimenez J, Rodrigo L, Simon Valles C, Rubio Lluesa C. Genes. 2020 Jun 29;11(7):724. doi: 10.3390/genes11070724. PMID: 32610655

Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2. Garrido Gomez T, Quinonero A, Dominguez F, Rubert L, Perales A, Hajjar K, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Apr;222(4):376.e1-376.e17. doi: 10.1016/j.ajog.2019.11.1250. PMID: 31738896

Preimplantation genetic testing for aneuploidy in patients with partial X monosomy using their own oocytes: is this a suitable indication?. Giles Jimenez J, Meseguer Escriva M, Mercader Bayarri A, Rubio Lluesa C, Alegre Ferri L, Vidal C, Trabalon M, Bosch Aparicio E. Fertility and Sterility. 2020 Aug;114(2):346-353. doi: 10.1016/j.fertnstert.2020.04.003. PMID: 32680612

Response to: Comments on the methodology of an endometrial receptivity array trial. Simon C, Gomez C, Ruiz M, Mol B, Valbuena D. Reproductive Biomedicine Online. 2020 Oct 3;S1472-6483(20)30533-2. doi: 10.1016/j.rbmo.2020.09.028. PMID: 33060012

Should vanishing twin pregnancies be systematically excluded from cell-free fetal DNA testing?. Balaguer N, Mateu Brull E, Serra V, Simon C, Milan M. Prenatal Diagnosis. 2020 Aug 24. doi: 10.1002/pd.5817. PMID: 32835421

Should we consider alternative therapies to operative hysteroscopy for the treatment of Asherman syndrome?. Santamaria Costa J, Liu J, Lusine A, Isaacson K, Movilla P, Fernandez H, Capmas P, Donnez J, Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):511-521. doi: 10.1016/j.fertnstert.2020.01.022. PMID: 32111470

Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle. Wang W, Vilella Mitjana F, Alama P, MORENO GIMENO I, Mignardi M, Isakova A, Pan W, Simon Valles C, Quake S. Nature Medicine. 2020 Oct;26(10):1644-1653. doi: 10.1038/s41591-020-1040-z. PMID: 32929266

Testing the mathematical model for PGT-A inefficiency with scientific sources demonstrates the efficacy of PGT-A. Capalbo A, Rubio Lluesa C, Simon Valles C. Human reproduction. 2020 Sep 1;35(9):2163-2165. doi: 10.1093/humrep/deaa172. PMID: 32766771

The dawn of the future: 30years from the first biopsy of a human embryo. The detailed history of an ongoing revolution. Cimadomo D, Rienzi L, Capalbo A, Rubio Lluesa C, Innocenti F, Garcia-Pascual C, Ubaldi F, Handyside A. Human Reproduction Update. 2020 Jun 18;26(4):453-473. doi: 10.1093/humupd/dmaa019. PMID: 32441746

The first glimpse of the endometrial microbiota in early pregnancy. Moreno Gimeno I, Garcia I, Bau D, Perez-Villaroya D, Gonzalez-Monfort M, Vilella Mitjana F, Romero R, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Apr;222(4):296-305. doi: 10.1016/j.ajog.2020.01.031. PMID: 32057732

The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances. Monteagudo-Sanchez A, Hernandez Mora J, Simon C, Burton A, Tenorio J, Lapunzina P, Clark S, Esteller M, Kelsey G, Lopez-Siguero J, de Nanclares G, Torres-Padilla M, Monk D. Nucleic ACIDS Research. 2020 Nov 18;48(20):11394-11407. doi: 10.1093/nar/gkaa837. PMID: 33053156

Time to pregnancy: as important for patients as underestimated by doctors. Roque M, Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):522-523. doi: 10.1016/j.fertnstert.2019.12.025. PMID: 32111473

Use of Customizable Nucleases for Gene Editing and Other Novel Applications. Reddy P, Vilella Mitjana F, Izpisua Belmonte J, Simon Valles C. Genes. 2020 Aug 22;11(9):976. doi: 10.3390/genes11090976. PMID: 32842577

25 historic papers: an ASRM 75th birthday gift from Fertility and Sterility. Niederberger C, Pellicer A, Simon C, Kathrins M, Goldstein M, Sigman M, Schlegel PN, Munné S, Gardner DK, Cobo A, Coutifaris C, Donnez J, Taylor HS, Giudice LC, Fauser BCJM, Lindheim SR, Rosenwaks Z, Casper RF, de Ziegler D, Gibbons WE, Paulson RJ, Laufer N, Klock SC, Mendola P, Sauer MV. Fertility and Sterility. 2019 Oct;112(4S1):e2-e27. doi: 10.1016/j.fertnstert.2019.08.099. PMID: 31623734

Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles. Carrasquillo RJ, Kohn TP, Cinnioglu C, Rubio C, Simon C, Ramasamy R, Al-Asmar N. Journal of Assisted Reproduction and Genetics. 2019 Oct;36(10):2039-2045. doi: 10.1007/s10815-019-01549-z. PMID: 31385121

An endometrial pathology in the inflammation cloud that can be accessed with a microbial app. Moreno I, Simon C. Fertility And Sterility. 2019 Apr;111(4):679-680. doi: 10.1016/j.fertnstert.2018.12.022. PMID: 30871763

Bioengineered uterus: a path toward ectogenesis. Bulletti C, Simon C. Fertility and Sterility. 2019 Sep;112(3):446-447. doi: 10.1016/j.fertnstert.2019.06.023. PMID: 31371052

Cellular therapies for the endometrium: An update. Queckbörner S, Davies LC, von Grothusen C, Santamaria X, Simón C, Gemzell-Danielsson K. Acta Obstetricia et Gynecologica Scandinavica. 2019 May;98(5):672-677. doi: 10.1111/aogs.13598. PMID: 30815850

Clinical application of embryo aneuploidy testing by NGS. Rubio C, Rodrigo L, Garcia-Pascual C, Peinado V, Campos-Galindo I, Garcia-Herrero S, Simón C. Biology of Reproduction. 2019 Dec 24;101(6):1083-1090. doi: 10.1093/biolre/ioz019. PMID: 30721942

Cost-effectiveness of preimplantation genetic testing for aneuploidies. Somigliana E, Busnelli A, Paffoni A, Vigano P, Riccaboni A, Rubio C, Capalbo A. Fertility and Sterility. 2019 Jun;111(6):1169-1176. doi: 10.1016/j.fertnstert.2019.01.025. PMID: 30777289

Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications. Rubio C, Rienzi L, Navarro-Sánchez L, Cimadomo D, García-Pascual CM, Albricci L, Soscia D, Valbuena D, Capalbo A, Ubaldi F, Simón C. Fertility and Sterility. 2019 Sep;112(3):510-519. doi: 10.1016/j.fertnstert.2019.04.038. PMID: 31200971

Happy Birthday to ASRM from Fertility and Sterility. Niederberger C, Pellicer A, Simon C. Fertility and Sterility. 2019 Oct;112(4S1):e1. doi: 10.1016/j.fertnstert.2019.08.098. PMID: 31623722

Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells. López-Pérez N, Gil-Sanchis C, Ferrero H, Faus A, Díaz A, Pellicer A, Cervelló I, Simón C. Reproductive Sciences. 2019 Jan;26(1):77-87. doi: 10.1177/1933719118766251. PMID: 29575998

Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR). Mateu-Brull E, Rodrigo L, Peinado V, Mercader A, Campos-Galindo I, Bronet F, García-Herrero S, Florensa M, Milán M, Rubio C. Journal of Assisted Reproduction and Genetics. 2019 Dec;36(12):2547-2555. doi: 10.1007/s10815-019-01593-9. PMID: 31696386

Introduction: Preconceptional care: do we have to care?. Simon C. Fertility and Sterility. 2019 Oct;112(4):611-612. doi: 10.1016/j.fertnstert.2019.08.056. PMID: 31561862

Is it time to reconsider microbial health in ART?. Moreno I. BJOG. 2019 Jan;126(2):208. doi: 10.1111/1471-0528.15219. PMID: 29542278

MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth. Balaguer N, Moreno I, Herrero M, Gonzáléz-Monfort M, Vilella F, Simón C. American Journal of Obstetrics and Gynecology. 2019 Jul;221(1):46.e1-46.e16. doi: 10.1016/j.ajog.2019.02.047. PMID: 30826341

Molecular differential diagnosis of uterine leiomyomas and leiomyosarcomas. Mas A, Simón C. Biology of Reproduction. 2019 Dec 24;101(6):1115-1123. doi: 10.1093/biolre/ioy195. PMID: 30184111

mtDNA dynamics between cleavage-stage embryos and blastocysts. De Munck N, Liñán A, Elkhatib I, Bayram A, Arnanz A, Rubio C, Garrido N, Lawrenz B, Fatemi HM. Journal of Assisted Reproduction and Genetics. 2019 Sep;36(9):1867-1875. doi: 10.1007/s10815-019-01544-4. PMID: 31392663

Optimizing clinical exome design for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes. Capalbo A, Valero RA, Jimenez-Almazan J, Pardo PM, Fabiani M, Jiménez D, Simon C, Rodriguez JM. PLOS Genetics. 2019 Oct 7;15(10):e1008409. doi: 10.1371/journal.pgen.1008409. PMID: 31589614

PGDIS Position Statement on the Transfer of Mosaic Embryos 2019. Cram DS, Leigh D, Handyside A, Rechitsky L, Xu K, Harton G, Grifo J, Rubio C, Fragouli E, Kahraman S, Forman E, Katz-Jaffe M, Tempest H, Thornhill A, Strom C, Escudero T, Qiao J, Munne S, Simpson JL, Kuliev A. Reproductive Biomedicine Online. 2019 Aug;39 Suppl 1:e1-e4. doi: 10.1016/j.rbmo.2019.06.012.. PMID: 31421710

Precision Medicine in Human Reproduction. Special Issue. Simon C, Sakkas D, Gardner D, Critchley H. Biology of Reproduction. 2019 Dec 24;101(6):1075. doi: 10.1093/biolre/ioz193. PMID: 31616936

Preconceptional care, where reproductive medicine meets obstetrics: the origins of lifetime health. Simon C, Romero R. Fertility and Sterility. 2019 Apr;111(4):657-658. doi: 10.1016/j.fertnstert.2019.02.006. PMID: 30929724

Reply: Bone marrow-derived endometrial cells: what you see is what you get. Santamaria X, Mas A, Cervelló I, Taylor HS, Simon C. Human Reproduction Update. 2019 Mar 1;25(2):274-275. doi: 10.1093/humupd/dmy042. PMID: 30601981

Selection of New Probiotics for Endometrial Health. Chenoll E, Moreno I, Sánchez M, Garcia-Grau I, Silva Á, González-Monfort M, Genovés S, Vilella F, Seco-Durban C, Simón C, Ramón D. Frontiers in Cellular and Infection Microbiology. 2019 Apr 17;9:114. doi: 10.3389/fcimb.2019.00114. PMID: 31058101

Should the reproductive risk of a couple aiming to conceive be tested in the contemporary clinical context?. Capalbo A, Chokoshvili D, Dugoff L, Franasiak J, Gleicher N, Pennings G, Simon C. Fertility and Sterility. 2019 Feb;111(2):229-238. doi: 10.1016/j.fertnstert.2018.11.045. PMID: 30642571

Sperm chromosomal abnormalities and their contribution to human embryo aneuploidy. Rodrigo L, Meseguer M, Mateu E, Mercader A, Peinado V, Bori L, Campos-Galindo I, Milán M, García-Herrero S, Simón C, Rubio C. Biology of Reproduction. 2019 Dec 24;101(6):1091-1101. doi: 10.1093/biolre/ioz125. PMID: 31318411

Taxonomical and Functional Assessment of the Endometrial Microbiota in A Context of Recurrent Reproductive Failure: A Case Report. Garcia-Grau I, Perez-Villaroya D, Bau D, Gonzalez-Monfort M, Vilella F, Moreno I, Simon C. Pathogens. 2019 Oct 24;8(4):205. doi: 10.3390/pathogens8040205. PMID: 31653041

The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing. Mas A, Alonso R, Garrido-Gómez T, Escorcia P, Montero B, Jiménez-Almazán J, Martín J, Pellicer N, Monleón J, Simón C. American Journal of Obstetrics and Gynecology. 2019 Oct;221(4):320.e1-320.e23. doi: 10.1016/j.ajog.2019.05.018. PMID: 31121144

To what extent is the testing of the reproductive risk of a couple aiming to conceive meaningful in the contemporary clinical context?. Simon C. Fertility and Sterility. 2019 Feb;111(2):227-228. doi: 10.1016/j.fertnstert.2018.11.046. PMID: 30642572

Unified diagnostic criteria for chronic endometritis at fluid hysteroscopy: proposal and reliability evaluation through an international randomized-controlled observer study. Cicinelli E, Vitagliano A, Kumar A, Lasmar RB, Bettocchi S, Haimovich S; International Working Group for Standardization of Chronic Endometritis Diagnosis. Fertility and Sterility. 2019 Jul;112(1):162-173.e2. doi: 10.1016/j.fertnstert.2019.03.004. PMID: 31104760

Uterine microbiome-low biomass and high expectations. Garcia-Grau I, Simon C, Moreno I. Biology of Reproduction. 2019 Dec 24;101(6):1102-1114. doi: 10.1093/biolre/ioy257. PMID: 30544156

Proyectos
Referencia: PI20/00942
Título: Desarrollo de u modelo predictivo para el diagnóstico diferencial temprano de leiomiomas y leiomiosarcomas uterinos
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: Aymara Mas Perucho
Duración: 2021 – 2023
Presupuesto: 99.825 €

Referencia: 874867 – HUTER
Título: Human Uterus Cell Atlas
Entidad Financiadora: European Commission
Investigador principal: Carlos Simón Vallés
Duración: 2020 – 2021
Presupuesto: 4.118.943 €

Referencia: PI19/01659
Título: Análisis transcriptómico a nivel de célula única y tejido endometrial completo del fallo en decidualización presente en pacientes con preclampsia severa
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: Tamara Garrido Gómez
Duración: 2020 – 2022
Presupuesto: 93.170 €

Referencia: RTI2018-094946-B-I00
Título: Contribución materna en la patogénesis de enfermedades gestacionales tardías como la preeclampsia
Entidad Financiadora: Ministerio de Ciencia, Innovación y Universidades
Investigador principal: Carlos Simón Vallés
Duración: 2019 – 2021
Presupuesto: 254.100 €

Referencia: PROMETEO/2018/161
Título: Medicina regenerativa del útero humano: desde la terapia celular a la creación del órgano mediante bioingeniería
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Carlos Simón Vallés
Duración: 2018 – 2021
Presupuesto: 297.066 €

Referencia: BFU 2015-72131-EXP
Título: Criptocromos, la inexplicable presencia de sensores de luz en la oscuridad que conectan el embrión temprano con el cosmos
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Carlos Simón Vallés
Duración: 2017 – 2019
Presupuesto: 60.000 €

+ Información
Título: Maternal-fetal crosstalk. Elucitaing the role of mir30d in endometrial receptivity and pregnancy outcome
Doctorando: Balaguer Cuenca, Nuria
Director: Vilella Mitjana, Felipe; Simón Vallés, Carlos
Fecha: 14/01/2019
Universidad: Universitat de València

Título: Epigenetic analysis of cell-free dna as a tool to study pathogenesis and maternal syndrome of preeclampsia
Doctorando: Corachán García, Irene
Director: Simón Vallés, Carlos; Díez Juan, Antonio; Vilella Mitjana, Felipe
Fecha: 14/02/2020
Universidad: Universitat de València

Título: Extracellular vesicles in the human maternal-embryo crosstalk during the preconception period
Doctorando: Bolumar Recuero, David
Director: Simón Vallés, Carlos; Vilella Mitjana, Felipe
Fecha: 21/12/2020
Universidad: Universitat de València

Título: Decidualización defectuosa durante y después de un embarazo con preeclampsia revela la contribución materna en la etiología de la enfermedad
Doctorando: Rubert Torró, Laura
Director: Perales Marín, Alfredo; Simón Vallés, Carlos; Garrido Gómez, Tamara
Fecha: 08/02/2021
Universidad: Universitat de València