Dr. Carlos Simón Vallés

Investigador Principal
Grupo de Investigación en Medicina Reproductiva

Presentación

El profesor Simón se licenció en Medicina y Cirugía por la Universidad de Valencia en 1985 con Premio Extraordinario de Licenciatura, obteniendo el Doctorado un año después. En la actualidad es Médico Especialista y Catedrático de Obstetricia y Ginecología de esa universidad; Senior Lecturer PT, BIDMC Harvard University, Boston, MA, USA; Adjunct Clinical Professor, Baylor College of Medicine, Houston, TX, USA. Además es Director Científico y Fundador de IGENOMIX S.L. compañía referente mundial que ofrece servicios avanzados en genética reproductiva. Ha sido director de 40 Tesis Doctorales todas calificadas con “Sobresaliente Cum Laude”, incluyendo 5 Premios Extraordinarios de Doctorado y 5 Doctorados Europeos.
Desde 1991 ha contribuido con sus trabajos pioneros a la investigación y solución clínica de los problemas que afectan a la receptividad endometrial humana. Utilizando la tecnología de microarrays identificó y cuantificó jerárquicamente los genes implicados en la receptividad endometrial humana. Cuenta con 9 patentes internacionales y 5 nacionales, destacando la relativa a la creación de un array customizado denominado endometrial receptivity array (ERA) para el diagnóstico molecular de la receptividad endometrial en pacientes infértiles. Ha sido el primero en descubrir las células madre somáticas que aisladas son capaces de reconstruir el endometrio humano.

Es uno de los científicos españoles más prolíficos, un análisis bibliométrico independiente que estudió los trabajos publicados entre 2003 y 2005 en Biología de la Reproducción, identificó al Dr. Simón como el noveno autor más productivo del mundo. Ha publicado un total de 493 trabajos en revistas internacionales peer-review que suman un índice de impacto de 2.393,24 las cuales han recibido 36.575 citas y su índice H es de 107 (Google Scholar), es editor de 19 libros, siendo “Stem Cells in Reproductive Medicine” un BestSeller en 2007.

Su impacto científico se ha traducido en múltiples galardones, de prestigiosas entidades Científicas como la Sociedad Española de Fertilidad (SEF); Society for Gynecologic Investigation (SGI); American Society for Reproductive Medicine (ASRM); Serono Symposia International Foundation y European Society of Human Reproduction and Embryology (ESHRE). En 2011 recibió el Premio Rey Jaime I de investigación médica y en 2016 el American Society for Reproductive Medicine Distinguished Research Award.

Investigador
Principal
Dr. Carlos Simón Vallés

carlos.simon@uv.es

Publicaciones
Embryo Genetics. Rubio C, Simon C. Genes. 2021 Jan 19;12(1):118. doi: 10.3390/genes12010118. PMID: 33477974

Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data. Capalbo A, Poli M, Riera-Escamilla A, Shukla V, Kudo Hoffding M, Krausz C, Hoffmann E, Simon Valles C. Human Reproduction Update. 2021 Feb 19;27(2):254-279. doi: 10.1093/humupd/dmaa044. PMID: 33197264

Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility. Garrido N, Cruz F, Egea R, Simon C, Sadler-Riggleman I, Beck D, Nilsson E, Ben Maamar M, Skinner M. Clinical Epigenetics. 2021 Jan 7;13(1):6. doi: 10.1186/s13148-020-00995-2. PMID: 33413568

A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF. Simon Valles C, Gomez C, Cabanillas S, Vladimirov I, Castillon G, Giles Jimenez J, Boynukalin K, Findikli N, Bahceci M, Ortega I, Vidal C, Funabiki M, Izquierdo A, Lopez L, Portela S, Frantz N, Kulmann M, Taguchi S, Labarta E, Colucci F, Mackens S, Santamaria X, Munoz E, Barrera S, Garcia-Velasco J, Fernandez M, Ferrando M, Ruiz M, Mol B, Valbuena Parilla D, Era-Rct Study Consortium Group. Reproductive Biomedicine Online. 2020 Sep;41(3):402-415. doi: 10.1016/j.rbmo.2020.06.002. PMID: 32723696

Bacterial Vaginosis and Its Association with Infertility, Endometritis, and Pelvic Inflammatory Disease. Ravel J, Moreno Gimeno I, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Oct 19;S0002-9378(20)31193-5. doi: 10.1016/j.ajog.2020.10.019. PMID: 33091407

Characteristics of the IVF Cycle that Contribute to the Incidence of Mosaicism. Rodrigo L, Clemente-Ciscar M, Campos-Galindo I, Peinado V, Simon Valles C, Rubio Lluesa C. Genes. 2020 Sep 30;11(10):1151. doi: 10.3390/genes11101151. PMID: 33007801

Combined Preimplantation Genetic Testing for Autosomal Dominant Polycystic Kidney Disease: Consequences for Embryos Available for Transfer. Mir Pardo P, Martinez-Conejero J, Martin J, Simon Valles C, Cervero A. Genes. 2020 Jun 24;11(6):692. doi: 10.3390/genes11060692. PMID: 32599795

Decidualization resistance in the origin of preeclampsia. Garrido Gomez T, Castillo Marco N, Cordero T, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Sep 29;S0002-9378(20)31130-3. doi: 10.1016/j.ajog.2020.09.039. PMID: 33007270

Endometrial Decidualization: The Primary Driver of Pregnancy Health. Ng S, Norwitz G, Pavlicev M, Tilburgs T, Simon Valles C, Norwitz E. International Journal of Molecular Sciences. 2020 Jun 8;21(11):4092. doi: 10.3390/ijms21114092. PMID: 32521725

Endometrial liquid biopsy provides a miRNA roadmap of the secretory phase of the human endometrium. Grasso A, Navarro R, Balaguer Cuenca N, Moreno Gimeno I, Alama P, Jimenez J, Simon Valles C, Vilella Mitjana F. Journal of Clinical Endocrinology & Metabolism. 2020 Mar 1;105(3):dgz146. doi: 10.1210/clinem/dgz146. PMID: 31665361

Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos. Girardi L, Serdarogullari M, Patassini C, Poli M, Fabiani M, Caroselli S, Coban O, Findikli N, Boynukalin F, Bahceci M, Chopra R, Canipari R, Cimadomo D, Rienzi L, Ubaldi F, Hoffmann E, Rubio Lluesa C, Simon Valles C, Capalbo A. American Journal of Human Genetics. 2020 Apr 2;106(4):525-534. doi: 10.1016/j.ajhg.2020.03.005. PMID: 32220293

Introduction: How evident is the evidence?. Simon Valles C. Fertility and Sterility. 2020 Jun;113(6):1091-1092. doi: 10.1016/j.fertnstert.2020.03.018. PMID: 32482243

Menstruation: science and society. Critchley H, Babayev E, Bulun S, Clark S, Garcia-Grau I, Gregersen P, Kilcoyne A, Kim J, Lavender M, Marsh E, Matteson K, Maybin J, Metz C, Moreno I, Silk K, Sommer M, Simon C, Tariyal R, Taylor H, Wagner G, Griffith L. American Journal of Obstetrics and Gynecology. 2020 Nov;223(5):624-664. doi: 10.1016/j.ajog.2020.06.004. PMID: 32707266

Multicenter prospective study of concordance between embryo cell-free DNA and trophectoderm biopsies from 1,301 human blastocysts. Rubio Lluesa C, Navarro-Sanchez L, Garcia-Pascual C, Ocali O, Cimadomo D, Venier W, Barroso G, Kopcow L, Bahceci M, Roos Kulmann M, Lopez L, De La Fuente E, Navarro R, Valbuena Parilla D, Sakkas D, Rienzi L, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Nov;223(5):751.e1-751.e13. doi: 10.1016/j.ajog.2020.04.035. PMID: 32470458

Operative hysteroscopy should be repeated as many times as necessary for the treatment of refractory Asherman syndrome versus is there any alternative therapy worth considering?. Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):510. doi: 10.1016/j.fertnstert.2020.01.021. PMID: 32089254

Optimized NGS Approach for Detection of Aneuploidies and Mosaicism in PGT-A and Imbalances in PGT-SR. Garcia-Pascual C, Navarro-Sanchez L, Navarro R, Martinez L, Jimenez J, Rodrigo L, Simon Valles C, Rubio Lluesa C. Genes. 2020 Jun 29;11(7):724. doi: 10.3390/genes11070724. PMID: 32610655

Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2. Garrido Gomez T, Quinonero A, Dominguez F, Rubert L, Perales A, Hajjar K, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Apr;222(4):376.e1-376.e17. doi: 10.1016/j.ajog.2019.11.1250. PMID: 31738896

Response to: Comments on the methodology of an endometrial receptivity array trial. Simon C, Gomez C, Ruiz M, Mol B, Valbuena D. Reproductive Biomedicine Online. 2020 Oct 3;S1472-6483(20)30533-2. doi: 10.1016/j.rbmo.2020.09.028. PMID: 33060012

Should vanishing twin pregnancies be systematically excluded from cell-free fetal DNA testing?. Balaguer N, Mateu Brull E, Serra V, Simon C, Milan M. Prenatal Diagnosis. 2020 Aug 24. doi: 10.1002/pd.5817. PMID: 32835421

Should we consider alternative therapies to operative hysteroscopy for the treatment of Asherman syndrome?. Santamaria Costa J, Liu J, Lusine A, Isaacson K, Movilla P, Fernandez H, Capmas P, Donnez J, Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):511-521. doi: 10.1016/j.fertnstert.2020.01.022. PMID: 32111470

Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle. Wang W, Vilella Mitjana F, Alama P, MORENO GIMENO I, Mignardi M, Isakova A, Pan W, Simon Valles C, Quake S. Nature Medicine. 2020 Oct;26(10):1644-1653. doi: 10.1038/s41591-020-1040-z. PMID: 32929266

Testing the mathematical model for PGT-A inefficiency with scientific sources demonstrates the efficacy of PGT-A. Capalbo A, Rubio Lluesa C, Simon Valles C. Human reproduction. 2020 Sep 1;35(9):2163-2165. doi: 10.1093/humrep/deaa172. PMID: 32766771

The first glimpse of the endometrial microbiota in early pregnancy. Moreno Gimeno I, Garcia I, Bau D, Perez-Villaroya D, Gonzalez-Monfort M, Vilella Mitjana F, Romero R, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Apr;222(4):296-305. doi: 10.1016/j.ajog.2020.01.031. PMID: 32057732

The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances. Monteagudo-Sanchez A, Hernandez Mora J, Simon C, Burton A, Tenorio J, Lapunzina P, Clark S, Esteller M, Kelsey G, Lopez-Siguero J, de Nanclares G, Torres-Padilla M, Monk D. Nucleic ACIDS Research. 2020 Nov 18;48(20):11394-11407. doi: 10.1093/nar/gkaa837. PMID: 33053156

Time to pregnancy: as important for patients as underestimated by doctors. Roque M, Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):522-523. doi: 10.1016/j.fertnstert.2019.12.025. PMID: 32111473

Use of Customizable Nucleases for Gene Editing and Other Novel Applications. Reddy P, Vilella Mitjana F, Izpisua Belmonte J, Simon Valles C. Genes. 2020 Aug 22;11(9):976. doi: 10.3390/genes11090976. PMID: 32842577

25 historic papers: an ASRM 75th birthday gift from Fertility and Sterility. Niederberger C, Pellicer A, Simon C, Kathrins M, Goldstein M, Sigman M, Schlegel PN, Munné S, Gardner DK, Cobo A, Coutifaris C, Donnez J, Taylor HS, Giudice LC, Fauser BCJM, Lindheim SR, Rosenwaks Z, Casper RF, de Ziegler D, Gibbons WE, Paulson RJ, Laufer N, Klock SC, Mendola P, Sauer MV. Fertility and Sterility. 2019 Oct;112(4S1):e2-e27. doi: 10.1016/j.fertnstert.2019.08.099. PMID: 31623734

Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles. Carrasquillo RJ, Kohn TP, Cinnioglu C, Rubio C, Simon C, Ramasamy R, Al-Asmar N. Journal of Assisted Reproduction and Genetics. 2019 Oct;36(10):2039-2045. doi: 10.1007/s10815-019-01549-z. PMID: 31385121

An endometrial pathology in the inflammation cloud that can be accessed with a microbial app. Moreno I, Simon C. Fertility And Sterility. 2019 Apr;111(4):679-680. doi: 10.1016/j.fertnstert.2018.12.022. PMID: 30871763

Bioengineered uterus: a path toward ectogenesis. Bulletti C, Simon C. Fertility and Sterility. 2019 Sep;112(3):446-447. doi: 10.1016/j.fertnstert.2019.06.023. PMID: 31371052

Cellular therapies for the endometrium: An update. Queckbörner S, Davies LC, von Grothusen C, Santamaria X, Simón C, Gemzell-Danielsson K. Acta Obstetricia et Gynecologica Scandinavica. 2019 May;98(5):672-677. doi: 10.1111/aogs.13598. PMID: 30815850

Clinical application of embryo aneuploidy testing by NGS. Rubio C, Rodrigo L, Garcia-Pascual C, Peinado V, Campos-Galindo I, Garcia-Herrero S, Simón C. Biology of Reproduction. 2019 Dec 24;101(6):1083-1090. doi: 10.1093/biolre/ioz019. PMID: 30721942

Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications. Rubio C, Rienzi L, Navarro-Sánchez L, Cimadomo D, García-Pascual CM, Albricci L, Soscia D, Valbuena D, Capalbo A, Ubaldi F, Simón C. Fertility and Sterility. 2019 Sep;112(3):510-519. doi: 10.1016/j.fertnstert.2019.04.038. PMID: 31200971

Happy Birthday to ASRM from Fertility and Sterility. Niederberger C, Pellicer A, Simon C. Fertility and Sterility. 2019 Oct;112(4S1):e1. doi: 10.1016/j.fertnstert.2019.08.098. PMID: 31623722

Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells. López-Pérez N, Gil-Sanchis C, Ferrero H, Faus A, Díaz A, Pellicer A, Cervelló I, Simón C. Reproductive Sciences. 2019 Jan;26(1):77-87. doi: 10.1177/1933719118766251. PMID: 29575998

Introduction: Preconceptional care: do we have to care?. Simon C. Fertility and Sterility. 2019 Oct;112(4):611-612. doi: 10.1016/j.fertnstert.2019.08.056. PMID: 31561862

MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth. Balaguer N, Moreno I, Herrero M, Gonzáléz-Monfort M, Vilella F, Simón C. American Journal of Obstetrics and Gynecology. 2019 Jul;221(1):46.e1-46.e16. doi: 10.1016/j.ajog.2019.02.047. PMID: 30826341

Molecular differential diagnosis of uterine leiomyomas and leiomyosarcomas. Mas A, Simón C. Biology of Reproduction. 2019 Dec 24;101(6):1115-1123. doi: 10.1093/biolre/ioy195. PMID: 30184111

Optimizing clinical exome design for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes. Capalbo A, Valero RA, Jimenez-Almazan J, Pardo PM, Fabiani M, Jiménez D, Simon C, Rodriguez JM. PLOS Genetics. 2019 Oct 7;15(10):e1008409. doi: 10.1371/journal.pgen.1008409. PMID: 31589614

Precision Medicine in Human Reproduction. Special Issue. Simon C, Sakkas D, Gardner D, Critchley H. Biology of Reproduction. 2019 Dec 24;101(6):1075. doi: 10.1093/biolre/ioz193. PMID: 31616936

Preconceptional care, where reproductive medicine meets obstetrics: the origins of lifetime health. Simon C, Romero R. Fertility and Sterility. 2019 Apr;111(4):657-658. doi: 10.1016/j.fertnstert.2019.02.006. PMID: 30929724

Reply: Bone marrow-derived endometrial cells: what you see is what you get. Santamaria X, Mas A, Cervelló I, Taylor HS, Simon C. Human Reproduction Update. 2019 Mar 1;25(2):274-275. doi: 10.1093/humupd/dmy042. PMID: 30601981

Selection of New Probiotics for Endometrial Health. Chenoll E, Moreno I, Sánchez M, Garcia-Grau I, Silva Á, González-Monfort M, Genovés S, Vilella F, Seco-Durban C, Simón C, Ramón D. Frontiers in Cellular and Infection Microbiology. 2019 Apr 17;9:114. doi: 10.3389/fcimb.2019.00114. PMID: 31058101

Should the reproductive risk of a couple aiming to conceive be tested in the contemporary clinical context?. Capalbo A, Chokoshvili D, Dugoff L, Franasiak J, Gleicher N, Pennings G, Simon C. Fertility and Sterility. 2019 Feb;111(2):229-238. doi: 10.1016/j.fertnstert.2018.11.045. PMID: 30642571

Sperm chromosomal abnormalities and their contribution to human embryo aneuploidy. Rodrigo L, Meseguer M, Mateu E, Mercader A, Peinado V, Bori L, Campos-Galindo I, Milán M, García-Herrero S, Simón C, Rubio C. Biology of Reproduction. 2019 Dec 24;101(6):1091-1101. doi: 10.1093/biolre/ioz125. PMID: 31318411

Taxonomical and Functional Assessment of the Endometrial Microbiota in A Context of Recurrent Reproductive Failure: A Case Report. Garcia-Grau I, Perez-Villaroya D, Bau D, Gonzalez-Monfort M, Vilella F, Moreno I, Simon C. Pathogens. 2019 Oct 24;8(4):205. doi: 10.3390/pathogens8040205. PMID: 31653041

The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing. Mas A, Alonso R, Garrido-Gómez T, Escorcia P, Montero B, Jiménez-Almazán J, Martín J, Pellicer N, Monleón J, Simón C. American Journal of Obstetrics and Gynecology. 2019 Oct;221(4):320.e1-320.e23. doi: 10.1016/j.ajog.2019.05.018. PMID: 31121144

To what extent is the testing of the reproductive risk of a couple aiming to conceive meaningful in the contemporary clinical context?. Simon C. Fertility and Sterility. 2019 Feb;111(2):227-228. doi: 10.1016/j.fertnstert.2018.11.046. PMID: 30642572

Unified diagnostic criteria for chronic endometritis at fluid hysteroscopy: proposal and reliability evaluation through an international randomized-controlled observer study. Cicinelli E, Vitagliano A, Kumar A, Lasmar RB, Bettocchi S, Haimovich S; International Working Group for Standardization of Chronic Endometritis Diagnosis. Fertility and Sterility. 2019 Jul;112(1):162-173.e2. doi: 10.1016/j.fertnstert.2019.03.004. PMID: 31104760

Uterine microbiome-low biomass and high expectations. Garcia-Grau I, Simon C, Moreno I. Biology of Reproduction. 2019 Dec 24;101(6):1102-1114. doi: 10.1093/biolre/ioy257. PMID: 30544156

Proyectos
Referencia: RTI2018-094946-B-I00
Título: Contribución materna en la patogénesis de enfermedades gestacionales tardías como la preeclampsia
Entidad Financiadora: Ministerio de Ciencia, Innovación y Universidades
Investigador principal: Carlos Simón Vallés
Duración: 2019 – 2021
Presupuesto: 254.100 €

Referencia: PROMETEO/2018/161
Título: Medicina regenerativa del útero humano: desde la terapia celular a la creación del órgano mediante bioingeniería
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Carlos Simón Vallés
Duración: 2018 – 2021
Presupuesto: 297.066 €

+ Información
Título: Epigenetic analysis of cell-free dna as a tool to study pathogenesis and maternal syndrome of preeclampsia
Doctorando: Corachán García, Irene
Director: Simón Vallés, Carlos; Díez Juan, Antonio; Vilella Mitjana, Felipe
Fecha: 14/02/2020
Universidad: Universitat de València

Título: Decidualización defectuosa durante y después de un embarazo con preeclampsia revela la contribución materna en la etiología de la enfermedad
Doctorando: Rubert Torró, Laura
Director: Perales Marín, Alfredo; Simón Vallés, Carlos; Garrido Gómez, Tamara
Fecha: 08/02/2021
Universidad: Universitat de València

Título: Maternal-fetal crosstalk. Elucitaing the role of mir30d in endometrial receptivity and pregnancy outcome
Doctorando: Balaguer Cuenca, Nuria
Director: Vilella Mitjana, Felipe; Simón Vallés, Carlos
Fecha: 14/01/2019
Universidad: Universitat de València

Título: Extracellular vesicles in the human maternal-embryo crosstalk during the preconception period
Doctorando: Bolumar Recuero, David
Director: Simón Vallés, Carlos; Vilella Mitjana, Felipe
Fecha: 21/12/2020
Universidad: Universitat de València