Grupo de Estudio de Riesgo Cardiometabólico y Renal

Área de Cardiovascular

Comenzar el análisis de podocitos (identificación, cultivo y fenotipado) y sus derivados: micro-ARN, exosomas

Identificar redes de interacción RNA – mRNA circulante y exosomal no codificante asociadas a la progresión del daño renal

La integración de la metabolómica y la genómica en el estudio de factores relacionados con el desarrollo de daño renal

Desarrollo de estudios de caracterización hemodinámica no invasiva en patología vascular

Análisis de morbilidad y mortalidad ligada a la presencia de hipertensión y lesión renal

Desarrollo de estudios in vitro de adhesión plaquetaria y leucocitaria en tromboembolismo venoso

Estudios genéticos relacionados a la obesidad y al sobrepeso y tromboembolismo venoso

Desarrollo de ensayos clínicos de fase III y IV

Coordinador
Dr. Josep Redón i Mas
josep.redon@uv.es/jredon@uv.es

INVESTIGADORES
R4 Senior

Josep Redón i Mas    

R3 Consolidado

Fernando Martínez García
Mª José Forner Giner
Mª José Galindo Puerto
Mª José García-Fuster González-Alegre

R2 Novel / Emergente

Ana Ortega Gutiérrez
David Martí Aguado
Raquel Cortés Vergaz    

R1 Predoctoral

Adrián Ruiz Hernández
María Grau Pérez
Olga Martínez Arroyo

STAFF
Colaborador/a

Elena Solaz Moreno
Javier Díaz Carnicero
Jose Miguel Calderón Terol

Enfermero/a

Laura Cantero Milán

Técnico/a

Antonio Fernández Giménez
Noemí Dolz Gilba
Óscar Calaforra Juan

Apoyo
Publicaciones
Automated whole-liver MRI segmentation to assess steatosis and iron quantification in chronic liver disease. Marti-Aguado D, Jimenez-Pastor A, Alberich-Bayarri A, Rodriguez-Ortega A, Alfaro-Cervello C, Mestre-Alagarda C, Bauza M, Gallen-Peris A, Valero-Perez E, Ballester MP, Gimeno-Torres M, Perez-Girbes A, Benlloch S, Perez-Rojas J, Puglia V, Ferrandez A, Aguilera V, Escudero-Garcia D, Serra MA, Marti-Bonmati L. Radiology. 2022 Feb;302(2):345-354. doi: 10.1148/radiol.2021211027. PMID: 34783592

Cigarette smoking and liver diseases. Marti-Aguado D, Clemente-Sanchez A, Bataller R. Journal of Hepatology. 2022 Feb 4;S0168-8278(22)00029-0. doi: 10.1016/j.jhep.2022.01.016. PMID: 35131406

Down-regulation of the longevity-associated protein SIRT1 in peripheral blood mononuclear cells of treated HIV patients. Gruevska A, Moragrega A, Galindo M, Esplugues J, Blas-Garcia A, Apostolova N. Cells. 2022 Jan 20;11(3):348. doi: 10.3390/cells11030348. PMID: 35159154

Environmental-level exposure to metals and metal-mixtures associated with spirometry-defined lung disease in American Indian adults: Evidence from the Strong Heart Study. Sobel M, Navas-Acien A, Powers M, Grau-Perez M, Goessler W, Best LG, Umans J, Oelsner EC, Podalanczuk A, Sanchez TR. Environmental Research. 2022 May 1;207:112194. doi: 10.1016/j.envres.2021.112194. PMID: 34653410

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019. Fanciulli C, Berenguer J, Busca C, Vivancos MJ, Tellez MJ, Dominguez L, Domingo P, Navarro J, Santos J, Iribarren JA, Morano L, Artero A, Moreno J, Rivero-Roman A, Santos I, Giner L, Arminanzas C, Montero M, Manzardo C, Cifuentes C, Garcia C, Galindo MJ, Ferrero OL, Sanz J, de la Fuente B, Rodriguez C, Gaspar G, Perez L, Losa JE, Force L, Veloso S, Martinez-Alfaro E, Jarrin I, De Miguel M, Gonzalez Garcia J. HIV Medicine. 2022 Jan 17. doi: 10.1111/hiv.13229. PMID: 35037379

Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain. Delgado-Velandia M, Gonzalez-Marrachelli V, Domingo-Relloso A, Galvez-Fernandez M, Grau-Perez M, Olmedo P, Galan I, Rodriguez-Artalejo F, Amigo N, Briongos-Figuero L, Redon J, Martin-Escudero J, Monleon-Salvado D, Tellez-Plaza M, Sotos-Prieto M. International Journal of Behavioral Nutrition and Physical Activity. 2022 Jan 27;19(1):8. doi: 10.1186/s12966-021-01219-3. PMID: 35086546

Insights from matched office and ambulatory blood pressure in youth: clinical relevance. Lurbe E, Redon J, Alvarez J, Grau-Perez M, Martinez F, Mancia G. Hypertension. 2022 Mar 29;101161HYPERTENSIONAHA12218993. doi: 10.1161/HYPERTENSIONAHA.122.18993. PMID: 35345885

Levels and determinants of urinary cadmium in general population in Spain: Metal-MCC-Spain study. Munoz J, Lope V, Fernandez de Larrea-Baz N, Gomez-Ariza J, Dierssen-Sotos T, Fernandez-Tardon G, Aragones N, Amiano P, Gomez-Acebo I, Tardon A, Grau-Perez M, Garcia-Barrera T, Kogevinas M, Pollan M, Perez-Gomez B. Environmental Research. 2022 Feb 19;210:112959. doi: 10.1016/j.envres.2022.112959. PMID: 35189102

New insights of cardiovascular and renal protection in diabetic chronic kidney disease with finerenone. Redon J. Cardiovascular Research. 2022 Mar 25;118(5):e36-e37. doi: 10.1093/cvr/cvac024. PMID: 35333317

Real world data of anticoagulant treatment in non-valvular atrial fibrillation across renal function status. Calderon J, Martinez F, Fernandez A, Sauri I, Diaz J, Uso R, Trillo J, Redon J, Forner M. Scientific reports. 2022 Apr 12;12(1):6123. doi: 10.1038/s41598-022-10164-5. PMID: 35414001

Shorter time to discontinuation due to treatment failure in people living with HIV switched to dolutegravir plus either rilpivirine or lamivudine compared with integrase inhibitor-based triple therapy in a large Spanish cohort. Teira R, Diaz-Cuervo H, Aragao F, Castano M, Romero A, Roca B, Montero M, Galindo M, Munoz-Sanchez M, Espinosa N, Peraire J, Martinez E, De la Fuente B, Domingo P, Deig E, Merino M, Geijo P, Estrada V, Sepulveda M, Garcia J, Berenguer J, Curran A. Infectious Diseases and Therapy. 2022 Apr 11. doi: 10.1007/s40121-022-00630-y. PMID: 35399147

Temporal trends and geographic variability in the prescription of antiretroviral treatments in people living with HIV in Spain, 2004-2020. Ruiz-Alguero M, Hernando V, Riero M, Blanco Ramos J, de Zarraga Fernandez M, Galindo P, Perez-Gonzalez A, Diaz A, Suarez-Garcia I, Jarrin I, CoRIS Cohort. Journal of Clinical Medicine. 2022 Mar 29;11(7):1896. doi: 10.3390/jcm11071896. PMID: 35407504

The prevalence of high blood pressure and its determinants among Tunisian adolescents. Soua S, Ghammam R, Maatoug J, Zammit N, Ben Fredj S, Martinez F, Ghannem H. Journal of Human Hypertension. 2022 Apr 8. doi: 10.1038/s41371-022-00677-x. PMID: 35396537

Thiopurine adherence: high prevalence with low impact in UC outcomes. Gomez-Medina C, Capilla-Lozano M, Ballester Ferre M, Marti-Aguado D, Crespo A, Bosca-Watts M, Navarro Cortes P, Anton R, Pascual Moreno I, Tosca Cuquerella J, Minguez Perez M. Revista Española de Enfermedades Digestivas. 2022 Feb;114(2):76-82. doi: 10.17235/reed.2021.7630/2020. PMID: 33733802

Toxic metals and subclinical atherosclerosis in carotid, femoral, and coronary vascular territories: the aragon workers health study. Grau-Perez M, Caballero-Mateos MJ, Domingo-Relloso A, Navas-Acien A, Gomez-Ariza JL, Garcia-Barrera T, Leon-Latre M, Soriano-Gil Z, Jarauta E, Cenarro A, Moreno-Franco B, Laclaustra M, Civeira F, Casasnovas JA, Guallar E, Tellez-Plaza M. Arteriosclerosis, Thrombosis, And Vascular Biology. 2022 Jan;42(1):87-99. doi: 10.1161/ATVBAHA.121.316358. PMID: 34879710

A new score unveils a high prevalence of mild cognitive impairment in patients with nonalcoholic fatty liver disease. Gimenez-Garzo C, Fiorillo A, Ballester-Ferre M, Gallego J, Casanova-Ferrer F, Urios A, Benlloch S, Marti-Aguado D, San-Miguel T, Tosca J, Rios M, Monton C, Durban L, Escudero-Garcia D, Aparicio L, Felipo V, Montoliu C. Journal of Clinical Medicine. 2021 Jun 25;10(13):2806. doi: 10.3390/jcm10132806. PMID: 34202269

Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients. Olea B, Albert E, Torres I, Amat P, Remigia M, Gozalbo-Rovira R, Rodriguez-Diaz J, Buesa J, Blasco M, Redon J, Signes-Costa J, Navarro D. Journal of Clinical Virology. 2021 Sep;142:104943. doi: 10.1016/j.jcv.2021.104943. PMID: 34391981

Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: the LipoLab Study.. Pallares-Carratala V, Quesada J, Orozco-Beltran D, Amigo-Grau N, Lopez-Pineda A, Fernandez Gimenez A, Gil-Guillen V, Correig X, Masana L, Monleon Salvado D, Redón Mas J, Pascual R, Carratala-Munuera C. International Journal of Clinical Practice. 2021 Jan;75(1):e13610. doi: 10.1111/ijcp.13610. PMID: 32648987

Anthropometric indicators as a tool for diagnosis of obesity and other health risk factors: a literature review. Piqueras P, Ballester A, Dura-Gil J, Martinez-Hervas S, Redon J, Real J. Frontiers in Psychology. 2021 Jul 9;12:631179. doi: 10.3389/fpsyg.2021.631179. PMID: 34305707

Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The Hortega study. Galvez-Fernandez M, Grau-Perez M, Garcia-Barrera T, Ramirez-Acosta S, Gomez-Ariza J, Perez-Gomez B, Galan-Labaca I, Navas-Acien A, Redon J, Briongos-Figuero L, Duenas-Laita A, Perez-Castrillon J, Tellez-Plaza M, Martin-Escudero J. Free Radical Biology & Medicine. 2021 Jan;162:392-400. doi: 10.1016/j.freeradbiomed.2020.10.318. PMID: 33137469

Cardiovascular outcomes in patients at high cardiovascular risk with previous myocardial infarction or stroke. Boehm M, Schumacher H, Teo KK, Lonn EM, Lauder L, Mancia G, Redon J, Schmieder RE, Sliwa K, Marx N, Weber MA, Williams B, Yusuf S, Mann JF, Mahfoud F. Journal of Hypertension. 2021 Aug 1;39(8):1602-1610. doi: 10.1097/HJH.0000000000002822. PMID: 34188004

Cardiovascular system in the sars-CoV-2: impact of therapies. Redon J. Journal of Hypertension. 2021 Jul 1;39(7):1306-1308. doi: 10.1097/HJH.0000000000002860. PMID: 34074967

Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2. Ferrer MD, Sanchez Barrueco A, Martinez-Beneyto Y, Mateos-Moreno MV, Ausina-Marquez V, Garcia-Vazquez E, Puche-Torres M, Forner Giner MJ, Campos Gonzalez A, Santillan Coello JM, Alcala Rueda I, Villacampa Auba JM, Cenjor Espanol C, Lopez Velasco A, Santolaya Abad D, Garcia-Esteban S, Artacho A, Lopez-Labrador X, Mira A. Scientific Reports. 2021 Dec 22;11(1):24392. doi: 10.1038/s41598-021-03461-y. PMID: 34937855

Cost of Type 2 diabetes patients with chronic kidney disease based on real-world data: an observational population-based study in Spain. Uso-Talamantes R, Gonzalez-de-Julian S, Diaz-Carnicero J, Sauri-Ferrer I, Trillo-Mata J, Carrasco-Perez M, Navarro-Perez J, Gorriz J, Vivas-Consuelo D, Redon J. International Journal of Environmental Research and Public Health. 2021 Sep 18;18(18):9853. doi: 10.3390/ijerph18189853. PMID: 34574782

Digital pathology: accurate technique for quantitative assessment of histological features in metabolic-associated fatty liver disease. Marti-Aguado D, Rodriguez-Ortega A, Mestre-Alagarda C, Bauza M, Valero-Perez E, Alfaro-Cervello C, Benlloch S, Perez-Rojas J, Ferrandez A, Alemany-Monraval P, Escudero-Garcia D, Monton C, Aguilera V, Alberich-Bayarri A, Serra M, Marti-Bonmati L. Alimentary Pharmacology & Therapeutics. 2021 Jan;53(1):160-171. doi: 10.1111/apt.16100. PMID: 32981113

Effect of empagliflozin on exercise ability and symptoms in heart failure patients with reduced and preserved ejection fraction, with and without type 2 diabetes. Nunez-Gil I, Fernandez-Ortiz A, Maroud Eid C, Huang J, Romero R, Becerra-Munoz V, Uribarri A, Feltes G, Trabatoni D, Fernandez-Rozas I, Viana-Llamas M, Pepe M, Cerrato E, Bertaina M, Capel Astrua T, Alfonso E, Castro-Mejia A, Raposeiras-Roubin S, D’Ascenzo F, Espejo Paeres C, Signes-Costa J, Bardaji A, Fernandez-Perez C, Marin F, Fabregat-Andres O, Akin I, Estrada V, Macaya C. Cardiology Journal. 2021 Feb 11;42(6):700-710. doi: 10.1093/eurheartj/ehaa943. PMID: 33351892

Effects of HCV Eradication on Bone mineral density in HIV/HCV Coinfected Patients. Carrero, A, Berenguer J, Hontanon V, Guardiola JM, Navarro J, von Wichmann MA, Tellez MJ, Quereda C, Santos I, Sanz J, Galindo MJ, Hernandez Quero J, Jimenez Sousa MA, Perez Latorre L, Bellon JM, Resino S, Esteban H, Martinez E, Gonzalez Garcia J. Clinical Infectious Diseases. 2021 Oct 5;73(7):e2026-e2033. doi: 10.1093/cid/ciaa1396. PMID: 32930720

Genetic variation and urine cadmium levels: ABCC1 effects in the Strong Heart Family Study. Grau-Perez M, Voruganti V, Balakrishnan P, Haack K, Goessler W, Franceschini N, Redon J, Cole S, Navas-Acien A, Tellez-Plaza M. Environmental pollution. 2021 Feb 11;276:116717. doi: 10.1016/j.envpol.2021.116717. PMID: 33640655

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. NCD Risk Factor Collaboration NCD. ELife. 2021 Mar 9;10:e60060. doi: 10.7554/eLife.60060. PMID: 33685583

IgA-dominant infection-associated glomerulonephritis following SARS-CoV-2 infection. Perez A, Torregrosa I, D’Marco L, Juan I, Terradez L, Solis M, Moncho F, Carda-Batalla C, Forner M, Gorriz J. Viruses-Basel. 2021 Mar 31;13(4):587. doi: 10.3390/v13040587. PMID: 33807151

Immunoglobulin G4-related aortitis and severe aortic valve stenosis treated with transcatheter aortic valve replacement and immunosuppression. Viana D, Marcos-Garces V, Blas S, Fores J, Romano J, Baena J, Giner M, Suarez N, Chorro F, Fornas F. Canadian Journal of Cardiology. 2021 Nov;37(11):1873-1876. doi: 10.1016/j.cjca.2021.07.015. PMID: 34333027

Impact of obesity in kidney diseases. Kotsis V, Martinez F, Trakatelli C, Redon J. Nutrients. 2021 Dec 15;13(12):4482. doi: 10.3390/nu13124482. PMID: 34960033

Insights into glomerular filtration and albuminuria. Redon J, Selma-Soriano E, Cortes R. New England Journal of Medicine. 2021 Jul 29;385(5):477-478. doi: 10.1056/NEJMc2108129. PMID: 34320301

Kinetics of emergence of liver complications in HCV-infected patients and advanced fibrosis, with and without HIV-coinfection, after SVR. Corma-Gomez A, Macias J, Tellez F, Morano L, Rivero A, Serrano M, Rios MJ, Vera-Mendez FJ, Santos M, Real LM, Palacios R, Santos I, Geijo P, Imaz A, Merino D, Galindo MJ, Reus-Banuls S, Lopez-Ruz MA, Galera C, Pineda JA. AIDS (London, England). 2021 Nov 1;35(13):2119-2127. doi: 10.1097/QAD.0000000000002959. PMID: 34049354

Liver stiffness-based strategies predict absence of variceal bleeding in cirrhotic HCV-infected patients with and without HIV-coinfection after sustained virological response. Corma Gomez A, Macias J, Morano L, Rivero A, Tellez F, Rios MJ, Santos M, Serrano M, Palacios R, Merino D, Real LM, De Los Santos I, Vera Mendez FJ, Galindo MJ, Pineda JA. Clinical Infectious Diseases. 2021 Mar 1;72(5):e96-e102. doi: 10.1093/cid/ciaa1726. PMID: 33211801

Metal exposure and biomarker levels among e-cigarette users in Spain. Olmedo P, Rodrigo L, Grau-Perez M, Hilpert M, Navas-Acien A, Tellez-Plaza M, Pla A, Gil F. Environmental Research. 2021 Jul 10;202:111667. doi: 10.1016/j.envres.2021.111667. PMID: 34256077

Precise whole liver automatic segmentation and quantification of PDFF and R2* on MR images. Jimenez-Pastor A, Alberich-Bayarri A, Lopez-Gonzalez R, Marti-Aguado D, Frana M, Bachmann R, Mazzucco J, Marti-Bonmati L. European Radiology. 2021 Oct;31(10):7876-7887. doi: 10.1007/s00330-021-07838-5. PMID: 33768292

Prognostic value of diagnostic scales in community-acquired sepsis mortality at an emergency service. Prognosis in community-adquired sepsis. Clar J, Oltra MR, Benavent R, Pinto C, Ruiz A, Sanchez MT, Noceda J, Redon J, Forner MJ. BMC Emergency Medicine. 2021 Dec 18;21(1):161. doi: 10.1186/s12873-021-00532-1. PMID: 34922448

Rabphilin silencing causes dilated cardiomyopathy in a Drosophila model of nephrocyte damage. Selma-Soriano E, Casillas-Serra C, Artero R, Llamusi B, Navarro J, Redon J. Scientific Reports. 2021 Jul 27;11(1):15287. doi: 10.1038/s41598-021-94710-7. PMID: 34315987

Renal function and attributable risk of death and cardiovascular hospitalization in participants with diabetes from a registry-based cohort. Ruiz-Quintero M, Redón Mas J, Tellez-Plaza M, Cebrian-Cuenca A, Navarro Perez J, Menendez E, Perez-Navarro A, Fernandez-Gimenez A, Lopez-Pineda A, Quesada J, Pallares-Carratala V, Gil-Guillen V, Martín Moreno J, Bleda-Cano J, Carrascosa S, Carratala-Munuera C. Primary Care Diabetes. 2021 Feb;15(1):88-94. doi: 10.1016/j.pcd.2020.06.004. PMID: 32646765

Renal outcomes and blood pressure patterns in diabetic and nondiabetic individuals at high cardiovascular risk. Bohm M, Schumacher H, Teo K, Lonn E, Mahfoud F, Emrich I, Mancia G, Redon J, Schmieder R, Sliwa K, Lehrke M, Marx N, Weber M, Williams B, Yusuf S, Mann J. Journal of Hypertension. 2021 Apr 1;39(4):766-774. doi: 10.1097/HJH.0000000000002697. PMID: 33560052

Risk factors and management strategies associated with non-response to aminosalicylates for maintenance treatment in ulcerative colitis. Marti-Aguado D, Ballester M, Minguez M. Revista Espanola de Enfermedades Digestivas. 2021 Jun;113(6):447-453. doi: 10.17235/reed.2021.7797/2021. PMID: 33569968

SARS-CoV-2-reactive interferon-gamma-producing CD8+ T cells in patients hospitalized with Coronavirus Disease 2019. Gimenez Quiles E, Albert Vicent E, Torres Fink I, Remigia Pellicer M, Alcaráz Soriana M, Galindo Puerto M, Blasco Cortes M, Solano Vercet C, Forner Giner M, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):375-382. doi: 10.1002/jmv.26213. PMID: 32579268

Self-rated health among people living with HIV in Spain in 2019: a cross-sectional study. Ruiz-Alguero M, Hernando V, Marcos H, Gutierrez G, Perez-Elias M, de Quiros J, Pulido F, Gorgolas M, Sanz J, Suarez-Garcia I, Fernandez M, Losa J, Perez J, Ladrero M, Prieto M, Gonzalez G, Izquierdo A, Viloria L, Lopez I, Martinez E, Castrillejo D, Aranguren R, Belmonte M, Aranda-Garcia I, Arraiza A, Diaz A, Hospital Survey Study Group, Hop Survey Study Grp. BMC Infectious Diseases. 2021 Jan 30;21(1):129. doi: 10.1186/s12879-021-05815-3. PMID: 33516173

Small Rab GTPases in intracellular vesicle trafficking: the case of Rab3A/Raphillin-3a complex in the kidney. Martinez-Arroyo O, Selma-Soriano E, Ortega A, Cortes R, Redon J. International Journal of Molecular Sciences. 2021 Jul 18;22(14):7679. doi: 10.3390/ijms22147679. PMID: 34299299

Sources of psychological distress among primary care physicians during the COVID-19 pandemic’s first wave in Spain: a cross-sectional study. Cebrian-Cuenca A, Mira J, Caride-Miana E, Fernandez-Jimenez A, Orozco-Beltran D. Primary Health Care Research & Development. 2021 Oct 18;22:e55. doi: 10.1017/S1463423621000566. PMID: 34658322

Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation. Martinez MT, Monton-Bueno J, Simon S, Ortega B, Moragon S, Rosello S, Insa A, Navarro J, Sanmartin A, Julve A, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner MJ, Cano A, Silvestre A, Teruel A, Lluch A, Cervantes A, Chirivella Gonzalez I. ESMO open. 2021 May 11;6(3):100148. doi: 10.1016/j.esmoop.2021.100148. PMID: 33989988

The Experience With Health Care of Patients With Inflammatory Arthritis: A Cross-sectional Survey Using the Instrument to Evaluate the Experience of Patients With Chronic Diseases. de Toro J, Cea-Calvo L, García-Vivar ML, Pantoja L, Lerín-Lozano C, García-Díaz S, Galindo MJ, Marín-Jiménez I, Fernández S, Mestre Y, Orozco-Beltrán D. Journal of Clinical Rheumatology. 2019 Jul 25. doi: 10.1097/RHU.0000000000001155.. PMID: 31356399

Therapeutic Potential of Extracellular Vesicles in Hypertension-Associated Kidney Disease. Martinez-Arroyo O, Ortega A, Redon J, Cortes R. Hypertension. 2021 Jan;77(1):28-38. doi: 10.1161/HYPERTENSIONAHA.120.16064. PMID: 33222549

Transjugular intrahepatic portosystemic shunt reduces hospital care burden in patients with decompensated cirrosis. Ballester M, Lluch P, Gomez C, Capilla M, Tosca J, Marti-Aguado D, Guijarro J, Minguez M. Internal and Emergency Medicine. 2021 Sep;16(6):1519-1527. doi: 10.1007/s11739-020-02602-x. PMID: 33400160

Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis. Perez Hernandez J, Martínez Arroyo O, Ortega Gutiérrez A, Galera Martos M, Solis Salguero M, Chaves Martínez F, Redón Mas J, Forner Giner M, Cortés Vergaz R. Journal Of Nephrology. 2021 Aug;34(4):1157-1167. doi: 10.1007/s40620-020-00832-y. PMID: 32803682

Urinary- and Plasma-Derived Exosomes Reveal a Distinct MicroRNA Signature Associated With Albuminuria in Hypertension. Perez-Hernandez J, Riffo-Campos A, Ortega A, Martinez-Arroyo O, Perez-Gil D, Olivares D, Solaz E, Martinez F, Martinez-Hervas S, Chaves F, Redon J, Cortes R. Hypertension. 2021 Mar 3;77(3):960-971. doi: 10.1161/HYPERTENSIONAHA.120.16598. PMID: 33486986

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. NCD Risk Factor Collaboration. Lancet. 2021 Sep 11;398(10304):957-980. doi: 10.1016/S0140-6736(21)01330-1. PMID: 34450083

Acute kidney injury in heart failure: a population study. Holgado Sánchez J, Lopez Forte C, Fernández Giménez A, Saurí Ferrer M, Uso Talamantes R, Trillo Mata J, Vela Bernal S, Nuñez Villota J, Redón Mas J, Ruiz Hernandez A. Esc Heart Failure. 2020 Apr;7(2):415-422. doi: 10.1002/ehf2.12595. PMID: 32059081

Cardiac magnetic resonance-derived fibrosis, strain and molecular biomarkers of fibrosis in hypertensive heart disease. Pichler G, Redon J, Martinez F, Solaz E, Calaforra O, Andres M, Lopez B, Diez J, Oberbauer R, Adlbrecht C, Karth G, Maceira A. Journal of Hypertension. 2020 Oct;38(10):2036-2042. doi: 10.1097/HJH.0000000000002504. PMID: 32890280

Cardiac sarcoidosis as an incidental finding: A case report. Gabaldon-Perez A, Garcia-Blas S, Forner M, Lopez-Lereu M, Bonanad C. Heart & Lung. 2020;49(6):783-787. doi: 10.1016/j.hrtlng.2020.09.009. PMID: 32980628

Chronic kidney disease as a cardiovascular risk factor. Carmena Rodriguez R, Ascaso Gimilio J, Redón Mas J. Journal of Hypertension. 2020 Nov;38(11):2110-2121. doi: 10.1097/HJH.0000000000002506. PMID: 32649622

Co-detection of respiratory pathogens in patients hospitalized with Coronavirus viral disease-2019 pneumonia. Blasco Cortes M, Buesa Gomez J, Colomina Rodríguez F, Forner Giner M, Galindo Puerto M, Navarro Perez J, Noceda Bermejo J, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal Of Medical Virology. 2020 Oct;92(10):1799-1801. doi: 10.1002/jmv.25922. PMID: 32320082

Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension. Martínez Arroyo O, Ortega Gutiérrez A, Galera Martos M, Solaz Moreno E, Martinez Hervas S, Redón Mas J, Cortés Vergaz R. International Journal of Molecular Sciences. 2020 Sep 2;21(17):6390. doi: 10.3390/ijms21176390. PMID: 32887498

Drug use and antiretroviral therapy (ART) interactions: a qualitative study to explore the knowledge, beliefs, adherence, and quality of life of people living with HIV taking ART and illicit drugs. Fuster-Ruiz de Apodaca MJ, Castro-Granell V, Laguia A, Jaen A, Cenoz S, Galindo Puerto M. AIDS Research and Therapy. 2020 May 24;17(1):24. doi: 10.1186/s12981-020-00279-y. PMID: 32448214

Effectiveness and safety of first-line antiretroviral regimens in clinical practice: a multicentre cohort study. Alejos B, Suarez-Garcia I, Rava M, Bautista-Hernandez A, Gutierrez F, Dalmau D, Sagastagoitia I, Rivero A, Moreno S, Jarrin I, CoRIS. The Journal of Antimicrobial Chemotherapy. 2020 Oct 1;75(10):3004-3014. doi: 10.1093/jac/dkaa246. PMID: 32667674

Effects of Eradication of HCV on Cardiovascular Risk and Preclinical Atherosclerosis in HIV/HCV-Coinfected Patients. Carrero A, Berenguer J, Hontanon V, Navarro J, Hernandez-Quero J, Galindo Puerto M, Quereda C, Santos I, Tellez M, Ortega E, Sanz J, Medrano L, Perez-Latorre L, Bellon J, Resino S, Bermejo J, Gonzalez-Garcia J, Gesida 3603b Study Grp. JAIDS-Journal of Acquired Immune Deficiency Syndromes. 2020 Mar 1;83(3):292-300. doi: 10.1097/QAI.0000000000002260. PMID: 31913996

Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus. Ortega A, Martinez-Arroyo O, Forner M, Cortes R. Pharmaceutics. 2020 Dec 22;13(1):E3. doi: 10.3390/pharmaceutics13010003. PMID: 3374908

Factors associated with the number of drugs in darunavir/cobicistat regimens. Martinez E, Negredo E, Knobel H, Ocampo A, Sanz J, Garcia-Fraile L, Martin-Carbonero L, Lozano F, Gonzalez-Domenech C, Gutierrez M, Montero M, Boix V, Payeras A, Torralba M, Gonzalez-Cordon A, Moreno A, Alejos B, Perez-Elias M, Galindo Puerto M, GeSIDA 9316 CODAR Study Grp. Journal of Antimicrobial Chemotherapy. 2020 Jan 1;75(1):208-214. doi: 10.1093/jac/dkz399. PMID: 31586414

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. NCD Risk Factor Collaboration. Lancet. 2020 Nov 7;396(10261):1511-1524. doi: 10.1016/S0140-6736(20)31859-6. PMID: 33160572

How well are we performing the initial assessment of HIV-positive patients? Results from a multicentre cohort in Spain. Suarez-Garcia I, Alejos B, Delgado E, Rivero M, Pineda J, Jarrin I, Moreno S, del Amo J, Dalmau D, Navarro M, Gonzalez M, Blanco J, Garcia F, Rubio R, Iribarren J, Gutierrez F, Vidal F, Berenguer J, Gonzalez J, Jarrin I, Hernando V, Alejos B, Sanz N, Moreno C, Munoz-Fernandez M, Fernandez I, Fuentes J, Rico C, de la Fuente J, Concejo P, Azpilicueta E, Cohort Spanish HIV AIDS Network. HIV Medicine. 2020 Feb;21(2):128-134. doi: 10.1111/hiv.12817. PMID: 31702111

Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease. Borghi C, Agabiti-Rosei E, Johnson R, Kielstein J, Lurbe Ferrer E, Mancia G, Redón Mas J, Stack A, Tsioufis K. European Journal of Internal Medicine. 2020 Oct;80:1-11. doi: 10.1016/j.ejim.2020.07.006. PMID: 32739239

Identifying poor cardiorespiratory fitness in overweight and obese children and adolescents by using heart rate variability analysis under resting conditions. Redon Lurbe P, Grassi G, Redón Mas J, Alvarez Pitti J, Lurbe Ferrer E. Blood Pressure. 2020 Feb;29(1):13-20. doi: 10.1080/08037051.2019.1700777. PMID: 31829032

Impact of Acute Hemoglobin Falls in Heart Failure Patients: A Population Study. López Zumel M, Holgado Sánchez J, Ferrandez Izquierdo A, Saurí Ferrer M, Uso Talamantes R, Trillo Mata J, Vela Bernal S, Bea Serrano C, Nuñez Villota J, Ferrer Albero A, Gamez Payá J, Ruiz Hernandez A, Redón Mas J. Journal of Clinical Medicine. 2020 Jun 15;9(6):1869. doi: 10.3390/jcm9061869. PMID: 32549339

Impact of HIV on the survival of hepatocellular carcinoma in hepatitis C virus-infected patients. Merchante N, Rodriguez Fernandez M, Figueruela B, Rodriguez Arrondo F, Revollo B, Ibarra S, Tellez F, Merino E, Montero Alonso M, Galindo MJ, Rivero Juarez A, de Los Santos I, Delgado Fernandez M, Garcia Deltoro M, Vera Mendez FJ, Garcia MA, Aguirrebengoa K, Portu J, Rios Villegas MJ, Villalobos M, Aleman Valls MR, Minguez C, Galera C, Macias J, Pineda JA. AIDS. 2020 Aug 1;34(10):1497-1507. doi: 10.1097/QAD.0000000000002578. PMID: 32675563

Magnetic Resonance imaging analysis of liver fibrosis and inflammation: overwhelming gray zones restrict clinical use. Marti Aguado D, Rodriguez-Ortega A, Alberich-Bayarri A, Marti-Bonmati L. Abdominal Radiology. 2020 Nov;45(11):3557-3568. doi: 10.1007/s00261-020-02713-1. PMID: 32857259

Maintenance of virologic suppression and improvement in comorbidities after simplification to raltegravir plus boosted darunavir among treatment-experienced HIV-infected patients. Casado J, Vizcarra P, Blanco J, Montejano R, Negredo E, Espinosa N, Montero M, Mena A, Palacios R, Lopez J, Vergas J, Galindo Puerto M, Cabello A, Garcia Deltoro M, Diaz De Santiago A, BIRDi Study Grp. International Journal of STD & AIDS. 2020 Apr;31(5):467-473. doi: 10.1177/0956462419896478. PMID: 32138618

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. NCD Risk Factor Collaboration. International Journal of Epidemiology. 2020 Feb 1;49(1):173-192. doi: 10.1093/ije/dyz099. PMID: 31321439

Nutraceuticals and blood pressure control: a European Society of Hypertension position document. Borghi C, Tsioufis K, Agabiti-Rosei E, Burnier M, Cicero A, Clement D, Coca A, Desideri G, Grassi G, Lovic D, LURBE FERRER E, Kahan T, Kreutz R, Jelakovic B, Polonia J, Redón Mas J, Van De Borne P, Mancia G. Journal of Hypertension. 2020 May;38(5):799-812. doi: 10.1097/HJH.0000000000002353. PMID: 31977574

Optimization of small RNA library preparation protocol from human urinary exosomes. Olivares Gazquez M, Perez Hernandez J, Perez Gil D, Chaves Martínez F, Redón Mas J, Cortés Vergaz R. Journal of Translational Medicine. 2020 Mar 18;18(1):132. doi: 10.1186/s12967-020-02298-9. PMID: 32188466

p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to NNRTI. Gruevska A, Moragrega A, Galindo Puerto M, Esplugues Mota J, Blas García A, Apostolova N. Antiviral Research. 2020 Jun;178:104784. doi: 10.1016/j.antiviral.2020.104784. PMID: 32272174

Pulmonary thrombosis in situ’: risk factors, clinic characteristics and long-term evolution. Fletcher-Sanfeliu D, Redon J, Garcia-Granero A, Frasson M, Barreira I, Martinez-Leon J, Garcia-Fuster M. Blood Coagulation & Fibrinolysis. 2020 Oct;31(7):469-475. doi: 10.1097/MBC.0000000000000949. PMID: 32833808

Rab-rabphilin system in injured human podocytes stressed by glucose overload and angiotensin II. Martínez Arroyo O, Ortega Gutiérrez A, Perez Hernandez J, Chaves Martínez F, Redón Mas J, Cortés Vergaz R. American Journal of Physiology. Renal Physiology. 2020 Aug 1;319(2):F178-F191. doi: 10.1152/ajprenal.00077.2020. PMID: 32567349

Rabphilin involvement in filtration and molecular uptake in Drosophila nephrocytes suggests a similar role in human podocytes. Selma Soriano E, Llamusi Troisi M, Fernandez Costa J, Ozimski L, Artero Allepuz R, Redón Mas J. Disease Models & Mechanisms. 2020 Sep 21;13(9):dmm041509. doi: 10.1242/dmm.041509. PMID: 32680845

Real-life experience with 4 years of golimumab persistence in ulcerative colitis patients. Iborra M, Garcia-Morales N, Rubio S, Bertoletti F, Calvo M, Taxonera C, Bosca Watts M, Sierra M, Mancenido N, Beltran B, Castillejo O, Garcia-Planella E, Vera I, Alba C, Marti Aguado D, Ballester Ferre M, Cano-Sanz N, Pajares-Villarroya R, Cerrillo E, Canada A, Nos P. Scientific Reports. 2020 Oct 20;10(1):17774. doi: 10.1038/s41598-020-73577-0. PMID: 33082359

Redefining hypertension in children and adolescents: A review of the evidence considered by the European Society of Hypertension and American Academy of Pediatrics guidelines.Stabouli S, Redón Mas J, Lurbe Ferrer E. Journal of Hypertension. 2020 Feb;38(2):196-200. doi: 10.1097/HJH.0000000000002247. PMID: 31584513

Repositioning of the global epicentre of non-optimal cholesterol. NCD Risk Factor Collaboration (NCD-RisC). Nature. 2020 Jun;582(7810):73-77. doi: 10.1038/s41586-020-2338-1. PMID: 32494083

Resting heart rate and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk analysis from the ONTARGET/TRANSCEND trials.Böhm M, Schumacher H, Teo K, Lonn E, Mahfoud F, Ukena C, Mann J, Mancia G, Redón Mas J, Schmieder R, Sliwa K, Marx N, Weber M, Williams B, Yusuf S. European Heart Journal. 2020 Jan 7;41(2):231-238. doi: 10.1093/eurheartj/ehy808. PMID: 30590564

Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21. Hernandez-Walias F, Vazquez E, Pacheco Y, Rodriguez-Fernandez J, Perez-Elias M, Dronda F, Casado J, Moreno A, Hermida J, Quereda C, Hernando A, Tejerina-Picado F, Asensi V, Galindo Puerto M, Leal M, Moreno S, Vallejo A. Journal of Clinical Medicine. 2020 Mar 11;9(3):760. doi: 10.3390/jcm9030760. PMID: 32168859

Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19. de Dios E, Rios-Navarro C, Perez-Sole N, Gavara J, Marcos-Garces V, Rodríguez E, Carratalá A, Forner MJ, Navarro J, Blasco ML, Bondia E, Signes-Costa J, Vila JM, Forteza MJ, Chorro 1MJ, Bodi V. Journal of Clinical Medicine. 2020 Oct 28;9(11):E3484. doi: 10.3390/jcm9113484. PMID: 33126723

The influence of hemoglobin A1c levels on cardiovascular events and all-cause mortality in people with diabetes over 70 years of age. A prospective study. Orozco-Beltran D, Navarro Perez J, Cebrian-Cuenca A, Alvarez-Guisasola F, Caride-Miana E, Mora G, Quesada J, Lopez-Pineda A, Cardona-Llorens A, Redón Mas J, Gil-Guillen V, Ferrandez Izquierdo A, Carratala-Munuera C. Primary Care Diabetes. 2020 Dec;14(6):678-684. doi: 10.1016/j.pcd.2020.06.003. PMID: 32605878

Unraveling new factors associated with hypertension: the Mendelian randomization approach. Grau Pérez M, Redón Mas J. Journal of Hypertension. 2020 Jan;38(1):30-32. doi: 10.1097/HJH.0000000000002251. PMID: 31790017

Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology. Piepoli M, Abreu A, Albus C, Ambrosetti M, Brotons C, Catapano A, Corra U, Cosyns B, Deaton C, Graham I, Hoes A, Lochen M, Matrone B, Redón Mas J, Sattar N, Smulders Y, Tiberi M. European Journal of Preventive Cardiology. 2020 Jan;27(2):181-205. doi: 10.1177/2047487319893035. PMID: 31826679

Visit-to-visit blood pressure variability and renal outcomes: results from ONTARGET and TRANSCEND trials. Mancia G, Schumacher H, Bohm M, Mann J, Redón Mas J, Facchetti R, Schmieder R, Lonn E, Teo K, Yusuf S. Journal of Hypertension. 2020 Oct;38(10):2050-2058. doi: 10.1097/HJH.0000000000002567. PMID: 32694337

Week 48 Resistance Analyses of the Once-Daily, Single-Tablet Regimen Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) in Adults Living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials. Lathouwers E, Wong E, Brown K, et al. AIDS Research and Human Retroviruses. 2020 Jan;36(1):48-57. doi: 10.1089/AID.2019.0111. PMID: 31516033

Proyectos
Referencia: EHDEN – OMOP
Título: EHDEN. Harmonization Fund Holder
Entidad Financiadora: European Commission (3rd Health Program)
Investigador principal: Josep Redón i Mas
Duración: 2022 – 2023
Presupuesto: 50.000,00 €

Referencia: PI21/00249
Título: Identificación de ARN no codificantes en biopsia líquida con énfasis en exosomas como biomarcadores pronóstico de actividad en el lupus eritematoso sistémico. Implicación fisiopatológica en el daño renal
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Raquel Cortés Vergaz, Mª José Forner Giner
Duración: 2022 – 2024
Presupuesto: 135.520 €

Referencia: 945097-WELLBASED
Título: WELLBASED. Improving health, wellbeing and equality by evidenced-based urban policies for tackling energy poverty
Entidad Financiadora: European Commission
Investigador principal: Josep Redón i Mas
Duración: 2021 – 2025
Presupuesto: 395.250,00 €

Referencia: PI19/01796
Título: Implicaciones experimentales y clinicas del complejo proteico rabphilin-rab en daño renal en la diabetes mellitus tipo 2
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Josep Redón i Mas
Duración: 2020 – 2022
Presupuesto: 196.020 €

Referencia: PI18/01405
Título: Perfil de microRNAs exosomales y su valor pronostico a largo plazo en el lupus eritematoso sistemico. Asociacion con marcadores establecidos de daño renal
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Raquel Cortés Vergaz, Maria José Forner
Duración: 2019 – 2021
Presupuesto: 111.320 €

Referencia: 780495-BigMedilytics
Título: Big Data for Medical Analytics
Entidad Financiadora: European Commission
Investigador principal: Josep Redón i Mas
Duración: 2018 – 2021
Presupuesto: 1062136,25

Referencia: BodyPass
Título: API-ecosystem for cross-sectorial exchange of 3D personal data
Entidad Financiadora: European Commission
Investigador principal: Josep Redón i Mas
Duración: 2018 – 2020
Presupuesto: 351937,5

Referencia: PT17/0005/0017
Título: Plataforma de Innovación
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Josep Redón i Mas
Duración: 2018 – 2021
Presupuesto: 38.985 €

Referencia: BigData@Heart
Título: Big Data for Better Hearts
Entidad Financiadora: European Commission
Investigador principal: Josep Redón i Mas
Duración: 2017 – 2022
Presupuesto: 386250

Referencia: PI16/01402
Título: Estudio experimental in vivo e in vitro y la aplicación clínica del impacto de las proteínas del complejo Rhabphilin-Rab en el desarrollo del daño renal y cardiovascular
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Josep Redón i Mas
Duración: 2017 – 2019
Presupuesto: 194.205 €

Referencia: PROMETEO/2016/084
Título: Innovación tecnológica en la evaluación del sistema nervioso simpático en adolescentes y adultos jóvenes obesos: papel en la estratificación del riesgo e intervención terapéutica
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Josep Redón i Mas
Duración: 2016 – 2019
Presupuesto: 246.190 €

Referencia: ADVANTAGE
Título: Managing Frailty. A comprehensive approach to promote a disability-free advanced age in Europe: the ADVANTAGE initiative
Entidad Financiadora: European Commission (3rd Health Program)
Investigador principal: Josep Redón i Mas, José Viña Ribes
Duración: 2016 – 2019
Presupuesto: 130005

+ Información
Redefining hypertension in children and adolescents: A review of the evidence considered by the European Society of Hypertension and American Academy of Pediatrics guidelines.Stabouli S, Redón Mas J, Lurbe Ferrer E. Journal of Hypertension. 2020 Feb;38(2):196-200. doi: 10.1097/HJH.0000000000002247. PMID: 31584513

2018 ESC/ESH Guidelines for the management of arterial. Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I. Kardiologia Polska. 2019;77(2):71-159. doi: 10.5603/KP.2019.0018. PMID: 30816983

Impact of ESH and AAP hypertension guidelines for children and adolescents on office and ambulatory blood pressure-based classifications. Lurbe E, Torró I, Álvarez J, Aguilar F, Mancia G, Redon J, Redon P. Journal of Hypertension. 2019 Dec;37(12):2414-2421. doi: 10.1097/HJH.0000000000002229. PMID: 31688292

Título: Estudio prospectivo multicéntrico de precisión diagnóstica de los biomarcadores de imagen en las hepatopatías crónicas difusas
Doctorando: Marti Aguado, David
Director: Martí Bonmatí, Luis; Serra Desfilis, Miguel Ángel
Fecha: 29/06/2021
Universidad: Universitat de València

Título: Valor pronóstico de los cambios en la rigidez arterial en la hipertensión arterial esencial
Doctorando: Calaforra Juan, Oscar
Director: Redón Mas, Josep; Forner Giner, María José; Martínez García, Fernando
Fecha: 28/07/2020
Universidad: Universitat de València

Título: Sistema de biosensado fotónico para la detección de trombina, alérgenos y patógenos. Funcionalización química de chips fotónicos basados en estructuras de anillos resonantes
Doctorando: Sánchez Sánchez, Carlos
Director: Martí Sendra, Javier; Redón Mas, Josep; Peransí Llopis, Sergio Manuel
Fecha: 15/11/2019
Universidad: Universitat Politècnica de València

Título: Estudio de la evolución del sellado distal ilíaco en el tratamiento endovascular de la aorta abdominal
Doctorando: Bargay Juan, Pau
Director: Redon Mas, Josep; Plaza Martínez, Ángel
Fecha: 25/02/2019
Universidad: Universitat de València