Dra. Mª Jesús Sanz Ferrando

Investigador Principal
Grupo de Investigación en Inflamación

Presentación

Investigador
Principal
Dra. Mª Jesús Sanz Ferrando

maria.j.sanz@uv.es  

Publicaciones
L-selectin regulates human neutrophil transendothelial migration. Rahman I, Collado Sanchez A, Davies J, Rzeniewicz K, Abukscem S, Joachim J, Hoskins Green H, Killock D, Sanz M, Charras G, Parsons M, Ivetic A. Journal of Cell Science. 2021 Feb 8;134(3):jcs250340. doi: 10.1242/jcs.250340. PMID: 33408247

Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes. Ascaso P, Palanca A, Martinez-Hervas S, Sanz MJ, Ascaso JF, Piqueras L, Real JT. International Journal of Clinical Practice. 2021 Apr 30;e14302. doi: 10.1111/ijcp.14302. PMID: 33930221

Role of antiangiogenic VEGF-A165b in angiogenesis and systolic function after reperfused myocardial infarction. Rios Navarro C, Hueso Soler L, Diaz Cuevas A, Marcos Garcés V, Bonanad Lozano C, Ruiz Sauri A, Vila Salinas J, Sanz Ferrando M, Chorro Gascó F, Piqueras Ruiz L, Bodí Peris V. Revista espanola de Cardiologia (English ed.). 2021 Feb;74(2):131-139. doi: 10.1016/j.rec.2020.03.013. PMID: 32474003

The nuclear retinoid-related orphan receptor RORalpha controls adipose tissue inflammation in patients with morbid obesity and diabetes. Ortega R, Hueso L, Benito E, Ortega J, Civera M, Sanz M, Real J, Piqueras L. International Journal of Obesity. 2021 Feb 26. doi: 10.1038/s41366-021-00787-5. PMID: 33637954

1-(2 ‘-Bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D-2 Dopamine Receptors. Silva A, Vila Dasí L, Gomes Marques P, Moreno L, Loza M, Sanz Ferrando M, Cortes D, Castro M, Cabedo Escrig N. Journal Of Natural Products. 2020 Jan 24;83(1):127-133. doi: 10.1021/acs.jnatprod.9b00921. PMID: 31933369

Angiotensin II and leukocyte trafficking: New insights for an old vascular mediator. Role of redox-signaling pathways. Piqueras Ruiz L, Sanz Ferrando M. Free Radical Biology and Medicine. 2020 Sep;157:38-54. doi: 10.1016/j.freeradbiomed.2020.02.002. PMID: 32057992

Pharmacological modulation of redox signaling pathways in disease. Sanz Ferrando M, Alcaraz Tormo M. Free Radical Biology and Medicine. 2020 Sep;157:1-2. doi: 10.1016/j.freeradbiomed.2020.04.003. PMID: 32272159

Postprandial triglyceridemia is modulated by insulin resistance but not by grade of obesity in abdominal and morbid obese subjects. Moreno-Perez B, Benito E, Civera M, Alabadi B, Martinez-Hervas S, Peiro M, Gonzalez-Navarro H, Piqueras L, Jesus Sanz M, Ascaso J, Real J. International Journal of Clinical Practice. 2020 Oct 21;e13776. doi: 10.1111/ijcp.13776. PMID: 33089594

Changes in CDKN2A/2B expression associate with T-cell phenotype modulation in atherosclerosis and type 2 diabetes mellitus. Vinué Á, Martínez-Hervás S, Herrero-Cervera A, Sánchez-García V, Andrés-Blasco I, Piqueras L, Sanz MJ, Real JT, Ascaso JF, Burks DJ, González-Navarro H. Translational Research. 2019 Jan;203:31-48. doi: 10.1016/j.trsl.2018.08.003. PMID: 30176239

Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. Vila-Caballer M, González-Granado JM, Zorita V, Abu Nabah YN4, Silvestre-Roig C, Del Monte-Monge A, Molina-Sánchez P, Ait-Oufella H, Andrés-Manzano MJ, Sanz MJ, Weber C, Kremer L, Gutiérrez J, Mallat Z, Andrés V. Journal of Molecular and Cellular Cardiology. 2019 Jul;132:154-163. doi: 10.1016/j.yjmcc.2019.05.009. PMID: 31121182

Novel Immune Features of the Systemic Inflammation Associated with Primary Hypercholesterolemia: Changes in Cytokine/Chemokine Profile, Increased Platelet and Leukocyte Activation. Collado A, Marques P, Domingo E, Perello E, González-Navarro H, Martinez-Hervás S, Real JT, Piqueras L, Ascaso JF, Sanz MJ. Journal of Clinical Medicine. 2019 Jan; 8(1): 18. PMID: 30583563

Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPAR alpha/PPAR gamma Agonist Activity and Anti-inflammatory Effect. Bermejo A, Collado A, Barrachina I, Marqués P, El Aouad N, Franck X, Garibotto F, Dacquet C, Caignard DH, Suvire FD, Enriz RD, Piqueras L, Figadère B, Sanz MJ, Cabedo N, Cortes D. Journal of Natural Products. 2019 Jul 26;82(7):1802-1812. doi: 10.1021/acs.jnatprod.9b00003. PMID: 31268307

SGLT-2 (Sodium-Glucose Cotransporter 2) Inhibition Reduces Ang II (Anciotensin II)-Induced Dissecting Abdominal Aortic Aneurysm in ApoE (Apolipoprotein E) Knockout Mice. Ortega R, Collado A, Selles F, Gonzalez-Navarro H, Sanz MJ, Real JT, Piqueras L. Arteriosclerosis Thrombosis and Vascular Biology. 2019 Aug;39(8):1614-1628. doi: 10.1161/ATVBAHA.119.312659. PMID: 31294626

Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity. Vettorazzi M, Vila L, Lima S, Acosta L, Yépes F, Palma A, Cobo J, Tengler J, Malik I, Alvarez S, Marqués P, Cabedo N, Sanz MJ, Jampilek J, Spiegel S, Enriz RD. Archiv Der Pharmazie. 2019 Mar;352(3):e1800298. doi: 10.1002/ardp.201800298. PMID: 30648282

Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators. Bermejo A, Barrachina I, El Aouad N, Franck X, Chahboune N, Andreu I, Figadère B, Vila L, Hennuyer N, Staels B, Dacquet C, Caignard DH, Sanz MJ, Cortes D, Cabedo N. Bioorganic & Medicinal Chemistry. 2019 Dec 15;27(24):115162. doi: 10.1016/j.bmc.2019.115162. PMID: 31703893

Systemic Inflammation in Metabolic Syndrome: Increased Platelet and Leukocyte Activation, and Key Role of CX3CL1/CX3CR1 and CCL2/CCR2 Axes in Arterial Platelet-Proinflammatory Monocyte Adhesion. Marques P, Collado A, Martinez-Hervás S, Domingo E, Benito E, Piqueras L, Real JT, Ascaso JF, Sanz MJ. Journal of Clinical Medicine. 2019 May 18;8(5):708. doi: 10.3390/jcm8050708. PMID: 31109070

The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation. Romero A, San Hipólito-Luengo Á, Villalobos LA, Vallejo S, Valencia I, Michalska P, Pajuelo-Lozano N, Sánchez-Pérez I, León R, Bartha JL, Sanz MJ, Erusalimsky JD, Sánchez-Ferrer CF, Romacho T, Peiró C. Aging Cell. 2019 Jun;18(3):e12913. doi: 10.1111/acel.12913. PMID: 30773786

Proyectos
Referencia: PROMETEO/2019/032
Título: Una aproximación translacional desde la clínica a la experimentación animal: Estudio del papel del eje CCL11/CCR3 y la inflamación eosinofílica en la patología cardiovascular asociada a desórdenes metabólicos
Entidad Financiadora: Conselleria de Educación Cultura y Deporte
Investigador principal: Mª Jesús Sanz Ferrrando
Duración: 2020 – 2023
Presupuesto: 211.736 €

Referencia: SAF2017-89714-R
Título: Modulación farmacológica del sistema inmune como diana clave en la prevención de la enfermedad cardiovascular asociada a desordenes metabólicos. Síntesis de fármacos novedosos
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Mª Jesús Sanz Ferrando, Juan F. Ascaso Gimilio
Duración: 2018 – 2021
Presupuesto: 205.700 €

+ Información
Título: Chemokine axes and inflammatory status in metabolic syndrome. Effect of pcsk9 inhibitors in the systemic inflammation associated to familial hypercholesterolemia
Doctorando: Gomes Marques, Patrice
Director: Piqueras Ruiz, Laura; Sanz Ferrando, María Jesús
Fecha: 07/02/2020
Universidad: Universitat de València

Título: Study of the systemic inflammation associated to primary hypercholesterolemia, its modulation and its impact in atherosclerosis. Role of cxcl16/cxcr6 axis in abdominal aortic aneurysm formation
Doctorando: Collado Sánchez, Aida
Director: Sanz Ferrando, María Jesús; Piqueras Ruiz, Laura
Fecha: 22/07/2019
Universidad: Universitat de València