Grupo de Investigación en Síndromes Linfoproliferativos

Área de Oncología

Profundizar en el conocimiento del papel de la vía de señalización NOTCH1/FBXW7/PI3K/PTEN/AKT en la progresión de la leucemia linfocítica crónica B (CLL-B) a formas avanzadas. En las líneas celulares y en las células primarias del paciente, se ha observado una variación en el número de copias de genes tanto por FISH como por PCRq en los genes NOTCH1, FBXW7 y PTEN, con una relación inversa entre NOTCH1 y FBXW7/PTEN

Analizar la importancia clínica de los reordenamientos de myc, bcl-2 y bcl-6 en el linfoma difuso de células grandes. Se ha comproado que los pacientes con expresión concomitante de la proteína c-myc y bcl-2 presentan un peor pronóstico en cuanto a SLP y Sg que el resto

Estudio del estado mutacional de IgVH en CLL, iplementación de su impacto pronóstico en una amplia serie de pacientes. Se han estudiado nuevos marcadores moleculares (mutaciones TP53, BIRC3, MYD88, NOTCH1 y SF3B1) en la LLC mediante técnicas de secuenciación de nueva generación. Continúa la colaboración en el proyecto de secuenciación GENOMA CLL, con una actualización clínico-evolutiva

Ampliacion en la participación en proyectos de investigación clínica en CLL, linfomas refractarios y mieloma múltiple, con la incorporación de nuevos fármacos y en el diseño y desarrollo de nuevas opciones terapéuticas

Coordinador
Dra. Mª José Terol Casterá
maria.jose.terol@uv.es  

INVESTIGADORES
R4 Senior

Mª José Terol Casterá    

R3 Consolidado

Antonio Ferrández Izquierdo

R2 Novel / Emergente

Ana Isabel Teruel Casasús
Blanca Ferrer Lores

R1 Predoctoral
STAFF
Colaborador/a

Alicia Serrano Alcalá
Edelmira Martí Sáez
Raimundo Cervera Vidal

Enfermero/a

Esther Lozano García
Juan Ramón de Moya Romero
Mercedes Bou Moreno

Técnico/a
Apoyo
Publicaciones
A randomized phase II study comparing consolidation with a single dose of 90Y ibritumomab tiuxetan vs. maintenance with rituximab for two years in patients with newly diagnosed follicular lymphoma responding to R-CHOP. Long-term follow-up results. Lopez-Guillermo A, Canales M, Dlouhy I, Mercadal S, Briones J, Garcia-Sancho A, Sancho J, Moraleda J, Terol M, Salar A, Palomera L, Gardella S, Jarque I, Ferrer S, Bargay J, Lopez A, Panizo C, Muntanola A, Montalban C, Conde E, Hernandez M, Soler A, Marco J, Deben G, Marin J, Tomas J, PETHEMA GELTAMO GELCAB Spanish. Leukemia & Lymphoma. 2022 Jan;63(1):93-100. doi: 10.1080/10428194.2021.1971216. PMID: 34459702

SARS-CoV-2-reactive antibody detection after SARS-CoV-2 vaccination in hematopoietic stem cell transplant recipients: Prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC). Pinana J, Lopez-Corral L, Martino R, Montoro J, Vazquez L, Perez A, Martin-Martin G, Facal-Malvar A, Ferrer E, Pascual M, Sanz-Linares G, Gago B, Sanchez-Salinas A, Villalon L, Conesa-Garcia V, Olave M, Lopez-Jimenez J, Marcos-Corrales S, Garcia-Blazquez M, Garcia-Gutierrez V, Hernandez-Rivas J, Saus A, Espigado I, Alonso C, Hernani R, Solano C, Ferrer-Lores B, Guerreiro M, Ruiz-Garcia M, Munoz-Bellido J, Navarro D, Cedillo A, Sureda A, Infectious Complications Subcommittee of the Spanish Hematopoietic Stem, Cell Transplantation and Cell Therapy Group (GETH-TC). American Journal of Hematology. 2022 Jan 1;97(1):30-42. doi: 10.1002/ajh.26385. PMID: 34695229

Amplification of human beta-glucoronidase gene for appraising the accuracy of negative SARS-CoV-2 RT-PCR results in upper respiratory tract specimens. Albert Vicent E, Ferrer Lores B, Torres Fink I, Serrano Alcalá A, Alcaráz Soriana M, Buesa Gomez J, Solano Vercet C, Colomina Rodríguez F, Bueno Ferrando F, Huntley Pascual D, Olea Miguel B, Valdivia Piqueres A, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):48-50. doi: 10.1002/jmv.26112. PMID: 32484950

Assessing the potential association between SARS-CoV-2 RNA load in the respiratory tract and COVID-19 mortality. Albert E, Bracho M, Serrano A, Ferrer B, Gonzalez-Candelas F, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):1862-1864. doi: 10.1002/jmv.26644. PMID: 33135804

Automated whole-liver MRI segmentation to assess steatosis and iron quantification in chronic liver disease. Marti-Aguado D, Jimenez-Pastor A, Alberich-Bayarri A, Rodriguez-Ortega A, Alfaro-Cervello C, Mestre-Alagarda C, Bauza M, Gallen-Peris A, Valero-Perez E, Ballester MP, Gimeno-Torres M, Perez-Girbes A, Benlloch S, Perez-Rojas J, Puglia V, Ferrandez A, Aguilera V, Escudero-Garcia D, Serra MA, Marti-Bonmati L. Radiology. 2021 Nov 16;211027. doi: 10.1148/radiol.2021211027. PMID: 34783592

Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative. Bosch F, Navarro B, Crespo M, Alcoceba M, Sanchez J, Tazon B, Serrano A, Alvarez M, Serrano L, Alonso-Torres P, Villanueva M, Loriente C, Abrisqueta P, Peiro M, Garcia-Marco J, Gonzalez M, Terol M. Annals of Hematology. 2021 Mar;100(3):825-830. doi: 10.1007/s00277-020-04331-9. PMID: 33409623

CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review. Hernani R, Sancho A, Amat P, Hernandez-Boluda J, Perez A, Pinana J, Carretero C, Goterris R, Gomez M, Saus A, Ferrer B, Teruel A, Terol M, Solano C. Current Research in Translational Medicine. 2021 Jul 22;69(4):103304. doi: 10.1016/j.retram.2021.103304. PMID: 34303899

Cytomegalovirus-specific T-cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib. De la Asuncion C, Terol M, Saus A, Olea B, Gimenez E, Albert E, Lopez-Jimenez J, Andreu R, Garcia D, Fox L, Remigia M, Amat P, Solano C, Navarro D. British Journal of Haematology. 2021 Nov;195(4):637-641. doi: 10.1111/bjh.17732. PMID: 34402042

Diffuse lipomatosis of the thyroid gland. Marti-Fernandez R, Cassinello-Fernandez N, Palomares-Casasus S, Gomez-Adrian J, Ferrandez-Izquierdo A. American Surgeon. 2021 Jun 27:31348211029848. doi: 10.1177/00031348211029848. PMID: 34180266

Digital pathology: accurate technique for quantitative assessment of histological features in metabolic-associated fatty liver disease. Marti-Aguado D, Rodriguez-Ortega A, Mestre-Alagarda C, Bauza M, Valero-Perez E, Alfaro-Cervello C, Benlloch S, Perez-Rojas J, Ferrandez A, Alemany-Monraval P, Escudero-Garcia D, Monton C, Aguilera V, Alberich-Bayarri A, Serra M, Marti-Bonmati L. Alimentary Pharmacology & Therapeutics. 2021 Jan;53(1):160-171. doi: 10.1111/apt.16100. PMID: 32981113

Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia. Jimenez I, Tazon-Vega B, Abrisqueta P, Nieto JC, Bobillo S, Palacio-Garcia C, Carabia J, Valdes-Mas R, Munuera M, Puigdefabregas L, Parra G, Esteve-Codina A, Franco-Jarava C, Iacoboni G, Terol MJ, Garcia-Marco JA, Crespo M, Bosch F. Biomarker Research. 2021 May 20;9(1):37. doi: 10.1186/s40364-021-00290-z. PMID: 34016160

Lenalidomide and dexamethasone with or without clarithromycin in patients with multiple myeloma ineligible for autologous transplant: a randomized trial. Puig N, Hernandez MT, Rosinol L, Gonzalez E, de Arriba F, Oriol A, Gonzalez-Calle V, Escalante F, de la Rubia J, Gironella M, Rios R, Garcia-Sanchez R, Arguinano JM, Alegre A, Martin J, Gutierrez NC, Calasanz MJ, Martin ML, Couto MC, Casanova M, Arnao M, Perez-Persona E, Garzon S, Gonzalez MS, Martin-Sanchez G, Ocio EM, Coleman M, Encinas C, Vale AM, Teruel AI, Cortes-Rodriguez M, Paiva B, Cedena MT, San-Miguel JF, Lahuerta JJ, Blade J, Niesvizky R, Mateos MV. Blood Cancer Journal. 2021 May 21;11(5):101. doi: 10.1038/s41408-021-00490-8. PMID: 34021118

Multiple small bowel perforations during the treatment of primary intestinal extranodal natural killer/T-cell lymphoma, nasal type. Lapena-Rodriguez M, Garces-Albir M, Gadea-Mateo R, Mata-Cano D, Teruel A, Doracratto D, Munoz-Forner E, Ortega-Serrano J, Sabater L. British Journal of Haematology. 2021 Jun;193(5):e39-e42. doi: 10.1111/bjh.17229. PMID: 33928633

Real-World Characteristics and Outcome of Patients Treated With Single-Agent Ibrutinib for Chronic Lymphocytic Leukemia in Spain (IBRORS-LLC Study). Abrisqueta P, Loscertales J, Terol MJ, Ramirez Payer A, Ortiz M, Perez I, Cuellar-Garcia C, Fernandez de la Mata M, Rodriguez A, Lario A, Delgado J, Godoy A, Arguinano Perez JM, Berruezo MJ, Oliveira A, Hernandez-Rivas JA, Garcia Malo MD, Medina A, Garcia Martin P, Osorio S, Baltasar P, Fernandez-Zarzoso M, Marco F, Vidal Mancenido MJ, Smucler Simonovich A, Lopez Rubio M, Jarque I, Suarez A, Fernandez Alvarez R, Lancharro Anchel A, Rios E, Losada Castillo MC, Perez Persona E, Garcia Munoz R, Ramos R, Yanez L, Bello JL, Loriente C, Acha D, Villanueva M. Clinical Lymphoma, Myeloma & Leukemia. 2021 Dec;21(12):e985-e999. doi: 10.1016/j.clml.2021.07.022. PMID: 34511320

Restoration of the immune function as a complementary strategy to treat Chronic Lymphocytic Leukemia effectively. Moreno C, Munoz C, Terol MJ, Hernandez-Rivas JA, Villanueva M. Journal of Experimental & Clinical Cancer Research. 2021 Oct 15;40(1):321. doi: 10.1186/s13046-021-02115-1. PMID: 34654437

Solitary fibrous tumor: integration of clinical, morphologic, immunohistochemical and molecular findings in risk stratification and classification may better predict patient outcome. Machado I, Nieto Morales MG, Cruz J, Lavernia J, Giner F, Navarro S, Ferrandez A, Llombart-Bosch A. International Journal of Molecular Sciences. 2021 Aug 30;22(17):9423. doi: 10.3390/ijms22179423. PMID: 34502329

Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation. Martinez MT, Monton-Bueno J, Simon S, Ortega B, Moragon S, Rosello S, Insa A, Navarro J, Sanmartin A, Julve A, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner MJ, Cano A, Silvestre A, Teruel A, Lluch A, Cervantes A, Chirivella Gonzalez I. ESMO open. 2021 May 11;6(3):100148. doi: 10.1016/j.esmoop.2021.100148. PMID: 33989988

Acute myeloid leukemia with NPM1 mutation and favorable European LeukemiaNet category: outcome after preemptive intervention based on measurable residual disease. Bataller A, Onate G, Diaz-Beya M, Guijarro F, Garrido A, Vives S, Tormo Diaz M, Arnan M, Salamero O, Sampol A, Coll R, Vall-Llovera F, Oliver-Caldes A, Lopez-Guerra M, Pratcorona M, Zamora L, Villamón Ribate E, Rou G, Blanco A, Nomdedeu J, Colomer D, Brunet S, Sierra J, Esteve J, Grp Cooperativo Estudio Tratamient. British Journal of Haematology. 2020 Oct;191(1):52-61. doi: 10.1111/bjh.16857. PMID: 32510599

Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN-Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group. Ambros I, Tonini G, Potschger U, Gross N, Mosseri V, Beiske K, Berbegall A, Benard J, Bown N, Caron H, Combaret V, Couturier J, Defferrari R, Delattre O, Jeison M, Kogner P, Lunec J, Marques B, Martinsson T, Mazzocco K, Noguera R, Schleiermacher G, Valent A, Van Roy N, Villamon E, Janousek D, Pribill I, Glogova E, Attiyeh E, Hogarty M, Monclair T, Holmes K, Valteau-Couanet D, Castel V, Tweddle D, Park J, Cohn S, Ladenstein R, Beck-Popovic M, De Bernardi B, Michon J, Pearson A, Ambros P. Journal of Clinical Oncology. 2020 Nov 1;38(31):3685-3697. doi: 10.1200/JCO.18.02132. PMID: 32903140

Biological and clinical significance of dysplastic hematopoiesis in patients with newly-diagnosed multiple myeloma.. Maia C, Puig N, Cedena M, Goicoechea I, Valdes-Mas R, Vazquez I, Chillon M, Aguirre P, Sarvide S, Gracia-Aznarez F, Alkorta-Aranburu G, Calasanz M, Garcia-Sanz R, Gonzalez M, Gutierrez N, Martinez-Lopez J, Perez J, Merino J, Moreno C, Burgos L, Alignani D, Botta C, Prosper F, Matarraz S, Orfao A, Oriol A, Teruel Casasus A, de Paz R, de Arriba F, Hernandez Garcia M, Palomera L, Martinez R, Rosinol L, Mateos M, Lahuerta J, Blade J, San Miguel J, Paiva B. Blood. 2020 Jun 25;135(26):2375-2387. doi: 10.1182/blood.2019003382. PMID: 32970894

Clinical characteristics and outcome of SARS-CoV-2 infection in admitted patients with chronic lymphocytic leukemia from a single European country. Muntanola A, Villacampa G, Hernandez Rivas JA, Alonso R, Miras F, Osorio S, Baile M, Baltasar P, Lopez Jimenez J, Hernandez Rodriguez I, Valenciano S, Alfayate A, Gimeno E, Barez A, Oliveira AC, Riaza R, Romero P, Delgado J, Yanez L, Zabalza A, Torres A, Gomez Roncero MI, Crespo M, Cordoba R, Mateos Mazon JJ, Perez S, Andreu R, Labrador J, Ruiz ME, Velasquez CA, Terol MJ, Santiago R, Vidal MJ, Campoy Garcia F, Villalon L, Muina BS, Soler JA, Seri C, Sanchez MJ, Cuesta A, Ramos R, Sanchez Montalva A, Ruiz Camps I, Gonzalez M, Abrisqueta P, Bosch F. Experimental Hematology & Oncology. 2020 Dec 18;9(1):37. doi: 10.1186/s40164-020-00195-x. PMID: 33339537

Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia. Ballester Garcia S, Pineda Merlo B, Rodrigues P, Tormo Martin E, Terol Castera M, Eroles Asensio P. Genes. 2020 Jun 23;11(6):686. doi: 10.3390/genes11060686. PMID: 32585853

Controversial issues in soft tissue solitary fibrous tumors: A pathological and molecular review. Machado I, Nieto-Morales G, Cruz J, Navarro Fos S, Giner F, Ferrandez Izquierdo A, Lopez-Soto M, Lavernia J, Llombart-Bosch A. Pathology International. 2020 Mar;70(3):129-139. doi: 10.1111/pin.12894. PMID: 31904167

Cryptic insertions of the immunoglobulin light chain enhancer region near CCND1 in t(11;14)-negative mantle cell lymphoma. Fuster C, Martín-Garcia D, Balagué O, Navarro A, Nadeu F, Costa D, Prieto M, Salaverria I, Espinet B, Rivas-Delgado A, Terol MJ, Giné E, Forcada P, Ashton-Key M, Puente XS, Swerdlow SH, Beà S, Campo E. Haematologica. 2020 Aug;105(8):e408-e411. doi: 10.3324/haematol.2019.237073. PMID: 31753927

Easy One-Step Amplification and Labeling Procedure for Copy Number Variation Detection. Blesa Luján S, Olivares Gazquez M, Alic A, Serrano Alcalá A, Lendinez Tortajada V, Gonzalez Albert V, Olivares Ordoñez L, Martinez Hervas S, Juanes Tébar J, Marin P, Real Collado J, Navarro Cubells B, García García A, Chaves Martínez F, Ivorra C. Clinical Chemistry. 2020 Mar 1;66(3):463-473. doi: 10.1093/clinchem/hvaa002. PMID: 32068788

Impact of Acute Hemoglobin Falls in Heart Failure Patients: A Population Study. López Zumel M, Holgado Sánchez J, Ferrandez Izquierdo A, Saurí Ferrer M, Uso Talamantes R, Trillo Mata J, Vela Bernal S, Bea Serrano C, Nuñez Villota J, Ferrer Albero A, Gamez Payá J, Ruiz Hernandez A, Redón Mas J. Journal of Clinical Medicine. 2020 Jun 15;9(6):1869. doi: 10.3390/jcm9061869. PMID: 32549339

Impact of clinical features, cytogenetics, genetic mutations, and methylation dynamics of CDKN2B and DLC-1 promoters on treatment response to azacitidine. Martin Gonzalez I, Navarro Cubells B, Serrano Alcalá A, Villamón Ribate E, Calabuig Muñoz M, Solano Vercet C, Chaves Martínez F, Yague N, Orts M, Amat Martínez P, Fuentes Trillo A, Seda García E, García García F, Hernandez Boluda J, Tormo Diaz M. Annals of Hematology. 2020 Mar;99(3):527-537. doi: 10.1007/s00277-020-03932-8. PMID: 31989250

Intrasinusoidal HHV8-EBV-Positive Large B-Cell Lymphoma With Features of Germinotropic Lymphoproliferative Disorder. Martínez Ciarpaglini M, Valkov A, Hurtado M, Agusti Martinez J, Malave G, Ferrandez Izquierdo A. International Journal of Surgical Pathology. 2020 Oct;28(7):804-811. doi: 10.1177/1066896920921238. PMID: 32423260

Neoadjuvant treatment for locally advanced unresectable and borderline resectable pancreatic cancer: oncological outcomes at a single academic centre. Rosello S, Pizzo C, Huerta M, Munoz E, Aliaga R, Vera A, Alfaro-Cervello C, Jorda E, Garces-Albir M, Roda D, Dorcaratto D, Tarazona N, Torondel S, Guijarro J, Sanchiz V, Gambardella V, Fleitas-Kanonnikoff T, Lluch P, Pascual I, Ferrandez A, Sabater L, Cervantes A. ESMO Open. 2020 Nov;5(6):e000929. doi: 10.1136/esmoopen-2020-000929. PMID: 33229503

Noninvasive Imaging Estimation of Myocardial Iron Repletion Following Administration of Intravenous Iron: The Myocardial-IRON Trial. Nuñez Villota J, Miñana Escriva G, Cardells Beltran I, Palau P, Llacer P, Facila L, Almenar L, Lopez Lereu M, Monmeneu Menadas J, Amiguet Comins M, González D’gregorio J, Serrano Alcalá A, Montagud V, Lopez-Vilella R, Valero Picher E, Garcia Blas S, Bodí Peris V, De La Espriella Juan R, Lupon J, Navarro Perez J, Górriz Teruel J, Sanchis Fores J, Chorro Gascó F, Comin-Colet J, Bayes Genis A, Myocardial-IRON Investigators. Journal of the American Heart Association. 2020 Feb 18;9(4):e014254. doi: 10.1161/JAHA.119.014254. PMID: 32067585

RELINF: prospective epidemiological registry of lymphoid neoplasms in Spain. A project from the GELTAMO group. Bastos-Oreiro M, Muntanola A, Panizo C, Gonzalez-Barca E, Gonzalez de Villambrosia S, Cordoba R, Bello Lopez J, Gonzalez-Sierra P, Terol Castera M, Gutierrez A, Grande C, Jose Ramirez M, Iserte L, Perez E, Navarro B, Gomez P, Salar A, Luzardo H, Lopez A, Del Campo R, Garcia-Belmonte D, Jesus Vida M, Infante M, Antonio Queizan-Hernandez J, Novelli S, Moreno M, Penarrubia M, Gomez J, Domingo A, Donato E, Cruz Viguria M, Lopez F, Jose Rodriguez M, Pardal E, Noriega V, Andreu R, Penalver J, Martin A, Caballero D, Lopez-Guillermo A. Annals of Hematology. 2020 Apr;99(4):799-808. doi: 10.1007/s00277-020-03918-6. PMID: 32076827

Solitary fibrous tumor: a case series identifying pathological adverse factors-implications for risk stratification and classification (pg 1, 2019). Machado I, Morales G, Cruz J, Lavernia J, Giner F, Navarro Fos S, Ferrandez Izquierdo A, Llombart-Bosch A. Virchows Archiv. 2020 Apr;476(4):625-626. doi: 10.1007/s00428-019-02697-4. PMID: 31655865

Solitary fibrous tumor: a case series identifying pathological adverse factors-implications for risk stratification and classification. Machado I, Nieto Morales G, Cruz J, Lavernia J, Giner F, Navarro Fos S, Ferrandez Izquierdo A, Llombart-Bosch A. Virchows Archiv. 2020 Apr;476(4):597-607. doi: 10.1007/s00428-019-02660-3. PMID: 31529158

Srebf2 Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets. Andres-Blasco I, Blesa S, Vinue A, Gonzalez-Navarro H, Real J, Martinez-Hervas S, Carretero J, Ferrandez-Izquierdo A, Chaves F, Garcia-Garcia A. Nutrients. 2020 Oct 14;12(10):3130. doi: 10.3390/nu12103130. PMID: 33066385

The influence of hemoglobin A1c levels on cardiovascular events and all-cause mortality in people with diabetes over 70 years of age. A prospective study. Orozco-Beltran D, Navarro Perez J, Cebrian-Cuenca A, Alvarez-Guisasola F, Caride-Miana E, Mora G, Quesada J, Lopez-Pineda A, Cardona-Llorens A, Redón Mas J, Gil-Guillen V, Ferrandez Izquierdo A, Carratala-Munuera C. Primary Care Diabetes. 2020 Dec;14(6):678-684. doi: 10.1016/j.pcd.2020.06.003. PMID: 32605878

Proyectos
Referencia: PT20/00029
Título: Plataforma de Biobancos
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Antonio Ferrández Izquierdo
Duración: 2021 – 2023
Presupuesto: 265.650 €

Referencia: PT17/0015/0049
Título: Plataforma de Biobancos
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Antonio Ferrández Izquierdo
Duración: 2018 – 2020
Presupuesto: 84.150 €

+ Información
Empresa: EpiDisease
Año de incio: 2014
Investigadores: García Giménez, José Luis
Web: http://www.epidisease.com/