Grupo de investigación en neoplasias de línea mieloide

Área de Oncología

Análisis de los factores de riesgo de trombosis en mielofibrosis

Analizar pacientes diagnosticados de síndromes mielodisplásicos con deleción 20q y del(20q). Evaluar la incidencia, valor pronóstico e impacto en la respuesta a azacitidina

Analizar en pacientes diagnosticados de leucemias mieloides agudas y del(7q) la incidencia, valor pronóstico y potencial como diana terapéutica de deleciones cromosómicas del gen EZH2 y de alteraciones por mutaciones genéticas y otras mutaciones genéticas

Coordinador
Dra. Mar Tormo Díaz
maria.mar.tormo@uv.es; tormo_mar@gva.es

INVESTIGADORES
R4 Senior

Juan Carlos Hernández Boluda
Mar Tormo Díaz    

R3 Consolidado
R2 Novel / Emergente

Carlos Carretero Márquez
Iván Martín Castillo
Marisa Calabuig Muñoz
Montserrat Gómez Calafat

R1 Predoctoral

Irene Pastor Galán

STAFF
Colaborador/a

Eva Villamón Ribate

Enfermero/a

Alicia Borrero Abarca

Técnico/a
Apoyo
Publicaciones
A randomized phase 2 trial of azacitidine with or without durvalumab as first-line therapy for higher-risk myelodysplastic syndromes. Zeidan AM, Boss I, Beach CL, Copeland WB, Thompson E, Fox BA, Hasle VE, Ogasawara K, Cavenagh J, Silverman LR, Voso MT, Hellmann A, Tormo M, O’Connor T, Previtali A, Rose S, Garcia-Manero G. Blood Advances. 2022 Apr 12;6(7):2207-2218. doi: 10.1182/bloodadvances.2021005487. PMID: 34972214

A randomized phase 2 trial of azacitidine with or without durvalumab as first-line therapy for older patients with AML. Zeidan AM, Boss I, Beach CL, Copeland WB, Thompson E, Fox BA, Hasle VE, Hellmann A, Taussig DC, Tormo M, Voso MT, Cavenagh J, O’Connor T, Previtali A, Rose S, Silverman LR. Blood advances. 2022 Apr 12;6(7):2219-2229. doi: 10.1182/bloodadvances.2021006138. PMID: 34933333

Acute leukemia arising from myeloproliferative or myelodysplastic/myeloproliferative neoplasms: a series of 372 patients from the PETHEMA AML registry. Hernandez Boluda JC, Martinez Cuadron D, Pereira A, Rodriguez Veiga R, Boluda B, Gil C, Casal-Marini S, Serrano J, Martinez Lopez J, Bergua J, Algarra L, Bernal T, Lopez Lorenzo JL, Colorado M, Lopez A, Tormo M, Sayas MJ, Trigo F, Lopez Pavia M, Perez Simon JA, Lavilla Rubira E, Rodriguez Medina C, Rodriguez Gutierrez JI, Sanz Caballer MA, Montesinos P. Leukemia Research. 2022 Mar 6;115:106821. doi: 10.1016/j.leukres.2022.106821. PMID: 35286939

Allogeneic hematopoietic cell transplantation in patients with myeloid/lymphoid neoplasm with FGFR1-rearrangement: a study of the Chronic Malignancies Working Party of EBMT. Hernandez-Boluda J, Pereira A, Zinger N, Gras L, Martino R, Paneesha S, Finke J, Chinea A, Rambaldi A, Robin M, Saccardi R, Natale A, Snowden J, Tsirigotis P, Vallejo C, Wulf G, Xicoy B, Russo D, Maertens J, Daguindau E, Lenhoff S, Hayden P, Czerw T, McLornan D, Yakoub-Agha I. Bone Marrow Transplantation. 2022 Mar;57(3):416-422. doi: 10.1038/s41409-021-01553-x. PMID: 35066569

Booster effect after SARS-CoV-2 vaccination in immunocompromised hematology patients with prior COVID-19. Piñana JL, Garcia-Sanz R, Martino R, Garcia-Roa M, Martin-Martin GA, Risco-Gálvez I, Tormo M, Martinez-Barranco P, Marcos-Corrales S, Calabuig M, Conesa V, Teruel A, Ruiz-Pérez S, Solano C, Navarro D, Cedillo Á, Sureda A. Blood Advances. 2022 Jan 8;6(3):848-853. doi: 10.1182/bloodadvances.2021006326. PMID: 34905620

Correction: Allogeneic hematopoietic cell transplantation in patients with myeloid/lymphoid neoplasm with FGFR1-rearrangement: a study of the Chronic Malignancies Working Party of EBMT. Hernandez-Boluda J, Pereira A, Zinger N, Gras L, Martino R, Nikolousis E, Finke J, Chinea A, Rambaldi A, Robin M, Saccardi R, Natale A, Snowden J, Tsirigotis P, Vallejo C, Wulf G, Xicoy B, Russo D, Maertens J, Daguindau E, Lenhoff S, Hayden P, Czerw T, McLornan D, Yakoub-Agha I. Bone Marrow Transplantation. 2022 Mar 31. doi: 10.1038/s41409-022-01652-3. PMID: 35361897

European LeukemiaNet 2017 risk stratification for acute myeloid leukemia: validation in a risk-adapted protocol. Bataller A, Garrido A, Guijarro F, Onate G, Diaz-Beya M, Arnan M, Tormo M, Vives S, de Llano M, Coll R, Gallardo D, Vall-Llovera F, Escoda L, Garcia-Guinon A, Salamero O, Sampol A, Merchan B, Bargay J, Castano-Diez S, Esteban D, Oliver-Caldes A, Rivero A, Mozas P, Lopez-Guerra M, Pratcorona M, Zamora L, Costa D, Rozman M, Nomdedeu J, Colomer D, Brunet S, Sierra J, Esteve J. Blood advances. 2022 Feb 22;6(4):1193-1206. doi: 10.1182/bloodadvances.2021005585. PMID: 34911079

How I manage myeloproliferative neoplasm-unclassifiable: practical approaches for 2022 and beyond. McLornan D, Hargreaves R, Hernandez-Boluda J, Harrison C. British Journal of Haematology. 2022 Feb 22. doi: 10.1111/bjh.18087. PMID: 35191542

Impact of donor-derived CD34+infused cell dose on outcomes of patients undergoing allo-HCT following reduced intensity regimen for myelofibrosis: a study from the Chronic Malignancies Working Party of the EBMT. Czerw T, Iacobelli S, Malpassuti V, Koster L, Kroeger N, Robin M, Maertens J, Chevallier P, Watz E, Poire X, Snowden JA, Kuball J, Kinsella F, Blaise D, Remenyi P, Mear JB, Cammenga J, Rubio MT, Maury S, Daguindau E, Finnegan D, Hayden P, Hernandez-Boluda JC, McLornan D, Yakoub-Agha I. Bone Marrow Transplantation. 2022 Feb;57(2):261-270. doi: 10.1038/s41409-021-01540-2. PMID: 34853433

Multi-body-site colonization screening cultures for predicting multi-drug resistant Gram-negative and Gram-positive bacteremia in hematological patients. Torres I, Huntley D, Tormo M, Calabuig M, Hernandez-Boluda J, Terol M, Carretero C, de Michelena P, Perez A, Pinana J, Colomina J, Solano C, Navarro D. BMC Infectious Diseases. 2022 Feb 21;22(1):172. doi: 10.1186/s12879-022-07154-3. PMID: 35189833

Practical tips for managing FLT3 mutated acute myeloid leukemia with midostaurin. Sangerman M, Moreno A, Quintana A, Garcia-Vidal C, Rubio M, Diaz M, Vendranas M, Macias G. Expert Review of Hematology. 2022 Mar 25;1-12. doi: 10.1080/17474086.2022.2054801. PMID: 35332831

Prognostic heterogeneity of adult B-cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/TCF3-PBX1 treated with measurable residual disease-oriented protocols. Ribera J, Granada I, Morgades M, Gonzalez T, Ciudad J, Such E, Calasanz M, Mercadal S, Coll R, Gonzalez-Campos J, Tormo M, Garcia-Cadenas I, Gil C, Cervera M, Barba P, Costa D, Ayala R, Bermudez A, Orfao A, Ribera J, Programa Tratamiento Hemopatias Ma, Spanish Soc Hematology, SEHH. British Journal of Haematology. 2022 Feb;196(3):670-675. doi: 10.1111/bjh.17844. PMID: 34549416

Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1. Onate G, Bataller A, Garrido A, Hoyos M, Arnan M, Vives S, Coll R, Tormo M, Sampol MA, Escoda L, Salamero O, Garcia A, Bargay J, Aljarilla A, Nomdedeu JF, Esteve J, Sierra J, Pratcorona M. Blood Advances. 2022 Feb 8;6(3):882-890. doi: 10.1182/bloodadvances.2020004136. PMID: 34516636

Spanish Society of Hematology and Hemotherapy expert consensus opinion for SARS-CoV-2 vaccination in onco-hematological patients. Pinana J, Vazquez L, Martino R, de la Camara R, Sureda A, Rodriguez-Veiga R, Garrido A, Sierra J, Ribera J, Torrent A, Mateos M, de la Rubia J, Tormo M, Diez-Campelo M, Garcia-Gutierrez V, Alvarez-Larran A, Sancho J, MartinGarcia-Sancho A, Yanez L, Simon J, Barba P, Abrisqueta P, Alvarez-Twose I, Bonanad S, Lecumberri R, Ruiz-Camps I, Navarro D, Hernandez-Rivas J, Cedillo A, Garcia-Sanz R, Bosch F. Leukemia & Lymphoma. 2022 Mar;63(3):538-550. doi: 10.1080/10428194.2021.1992619. PMID: 34668835

Treatment patterns and outcomes of 2310 patients with secondary acute myeloid leukemia: a PETHEMA registry study. Martinez-Cuadron D, Megias-Vericat JE, Serrano J, Martinez-Sanchez P, Rodriguez-Arboli E, Gil C, Aguiar E, Bergua Burgues JM, Lopez-Lorenzo JL, Bernal T, Espadana A, Colorado M, Rodriguez-Medina C, Lopez-Pavia M, Tormo M, Algarra JL, Amigo ML, Sayas MJ, Labrador J, Rodriguez-Gutierrez JI, Benavente C, Costilla-Barriga L, Garcia-Boyero R, Lavilla E, Vives S, Herrera P, Garcia D, Herraez-Albendea MM, Esteves GV, Gomez-Roncero MI, Cabello A, Bautista G, Balerdi A, Mariz J, Boluda B, Sanz MA, Montesinos P. Blood Advances. 2022 Feb 22;6(4):1278-1295. doi: 10.1182/bloodadvances.2021005335. PMID: 34794172

Use of Venetoclax in Patients with Relapsed or Refractory Acute Myeloid Leukemia: The PETHEMA Registry Experience. Labrador J, Saiz-Rodriguez M, de Miguel D, de Laiglesia A, Rodriguez-Medina C, Vidriales M, Perez-Encinas M, Sanchez-Sanchez M, Cuello R, Roldan-Perez A, Vives S, Benzo-Callejo G, Colorado M, Garcia-Fortes M, Sayas M, Olivier C, Recio I, Conde-Royo D, Bienert-Garcia A, Vahi M, Munoz-Garcia C, Seri-Merino C, Tormo M, Vall-Llovera F, Foncillas M, Martinez-Cuadron D, Sanz M, Montesinos P. Cancers. 2022 Mar 29;14(7):1734. doi: 10.3390/cancers14071734. PMID: 35406512

A phase 3 trial of azacitidine versus a semi-intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia. Vives S, Martinez-Cuadron D, Bergua Burgues J, Algarra L, Tormo M, Martinez-Sanchez M, Serrano J, Herrera P, Ramos F, Salamero O, Lavilla E, Lopez-Lorenzo J, Gil C, Vidriales B, Falantes J, Serrano A, Labrador J, Sayas M, Foncillas M, Amador Barciela M, Olave M, Colorado M, Gascon A, Fernandez M, Simiele A, Perez-Encinas M, Rodriguez-Veiga R, Garcia O, Martinez-Lopez J, Barragan E, Paiva B, Sanz M, Montesinos P, PETHEMA Group. Cancer. 2021 Jun 15;127(12):2003-2014. doi: 10.1002/cncr.33403. PMID: 33626197

Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL). Genesca E, Morgades M, Gonzalez-Gil C, Fuster-Tormo F, Haferlach C, Meggendorfer M, Montesinos P, Barba P, Gil C, Coll R, Moreno MJ, Martinez-Carballeira D, Garcia-Cadenas I, Vives S, Ribera J, Gonzalez-Campos J, Diaz-Beya M, Mercadal S, Artola MT, Cladera A, Tormo M, Bermudez A, Vall-Llovera F, Martinez-Sanchez P, Amigo ML, Monsalvo S, Novo A, Cervera M, Garcia-Guinon A, Ciudad J, Cervera J, Hernandez-Rivas JM, Granada I, Haferlach T, Orfao A, Sole F, Ribera JM. Leukemia Research. 2021 Jun 8;109:106612. doi: 10.1016/j.leukres.2021.106612. PMID: 34139642

Allogeneic haematopoietic cell transplantation for myelofibrosis: proposed definitions and management strategies for graft failure, poor graft function and relapse: best practice recommendations of the EBMT Chronic Malignancies Working Party. McLornan D, Boluda J, Czerw T, Cross N, Deeg H, Ditschkowski M, Moonim M, Polverelli N, Robin M, Aljurf M, Conneally E, Hayden P, Yakoub-Agha I. Leukemia. 2021 Sep;35(9):2445-2459. doi: 10.1038/s41375-021-01294-2. PMID: 34040148

Allogeneic hematopoietic cell transplantation in older myelofibrosis patients: a study of the Chronic Malignancies Working Party of EBMT and the Spanish Myelofibrosis Registry. Hernandez-Boluda JC, Pereira A, Kroger N, Cornelissen JJ, Finke J, Beelen D, de Witte M, Wilson K, Platzbecker U, Sengeloev H, Blaise D, Einsele H, Sockel K, Kruger W, Lenhoff S, Salaroli A, Martin H, Garcia-Gutierrez V, Pavone V, Alvarez-Larran A, Raya JM, Zinger N, Gras L, Hayden P, Czerw T, McLornan D, Yakoub-Agha I. American Journal of Hematology. 2021 Oct 1;96(10):1186-1194. doi: 10.1002/ajh.26279. PMID: 34152630

An investigation of the potential association between gastrointestinal viral and bacterial infection and development of intestinal acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. Bueno F, Albert E, Gimenez E, Pinana J, Perez A, Gomez M, Hernandez-Boluda J, Gonzalez-Barbera E, Montoro J, Buesa J, Guerreiro M, Balaguer-Rosello A, Hernani R, Sanz J, Solano C, Navarro D. Journal of Medical Virology. 2021 Aug;93(8):4773-4779. doi: 10.1002/jmv.26892. PMID: 33605457

Biomarker profile predicts clinical efficacy of extracorporeal photopheresis in steroid-resistant acute and chronic graft-vs-host disease after allogenic hematopoietic stem cell transplant. Amat P, Lopez-Corral L, Goterris R, Perez A, Lopez O, Heras I, Arbona C, Viguria MC, Hernandez-Boluda JC, Martinez-Ruiz F, Martinez A, Solano C. Journal of Clinical Apheresis. 2021 Oct;36(5):697-710. doi: 10.1002/jca.21918. PMID: 34185332

CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review. Hernani R, Sancho A, Amat P, Hernandez-Boluda J, Perez A, Pinana J, Carretero C, Goterris R, Gomez M, Saus A, Ferrer B, Teruel A, Terol M, Solano C. Current Research in Translational Medicine. 2021 Jul 22;69(4):103304. doi: 10.1016/j.retram.2021.103304. PMID: 34303899

Chemotherapy or Allogeneic Transplantation in High-Risk Philadelphia Chromosome-Negative Adult Lymphoblastic Leukemia. Ribera J, Morgades M, Ciudad J, Montesinos P, Esteve J, Genesca E, Barba P, Ribera J, Garcia Cadenas I, Moreno M, Martinez-Carballeira D, Torrent A, Martinez-Sanchez P, Monsalvo S, Gil C, Tormo M, Artola M, Cervera M, Gonzalez-Campos J, Rodriguez-Medina C, Bermudez A, Novo A, Soria B, Coll R, Amigo M, Lopez A, Fernandez Martin R, Serrano J, Mercadal S, Cladera A, Gimenez-Conca A, Penarrubia M, Abella E, Vall-Llovera F, Hernandez-Rivas J, Garcia A, Bergua Burgues J, de Rueda B, Sanchez-Sanchez M, Serrano A, Calbacho M, Alonso Vence N, Mendez-Sanchez J, Garcia-Boyero R, Olivares M, Barrena S, Zamora L, Granada I, Lhermitte L, Feliu E, Orfao A. Blood. 2021 Apr 8;137(14):1879-1894. doi: 10.1182/blood.2020007311. PMID: 33150388

Correction: Allogeneic haematopoietic cell transplantation for myelofibrosis: proposed definitions and management strategies for graft failure, poor graft function and relapse: best practice recommendations of the EBMT Chronic Malignancies Working Party. McLornan D, Hernandez-Boluda J, Czerw T, Cross N, Deeg H, Ditschkowski M, Moonim M, Polverelli N, Robin M, Aljurf M, Conneally E, Hayden P, Yakoub-Agha I. Leukemia. 2021 Dec;35(12):3625. doi: 10.1038/s41375-021-01395-y. PMID: 34471230

Cytoreductive treatment in patients withCALR-mutated essential thrombocythaemia: a study comparing indications and efficacy among genotypes from the Spanish Registry of Essential Thrombocythaemia. Alvarez-Larran A, Angona A, Andrade-Campos M, Soledad Noya M, Teresa Gomez-Casares M, Cuevas B, Caballero G, Garcia-Hernandez C, Garcia-Gutierrez V, Palomino A, Ferrer-Marin F, Isabel Mata-Vazquez M, Moreto A, Magro E, Murillo I, Alonso-Dominguez J, Maria Guerra J, Guerrero L, Maria Raya J, Perez-Encinas M, Carreno-Tarragona G, Fox L, Pastor Galan I, Bellosillo B, Hernandez Boluda J, MPN Spanish Grp Gemfin. British Journal of Haematology. 2021 Mar;192(6):988-996. doi: 10.1111/bjh.16988. PMID: 32745264

Determinants of survival in myelofibrosis patients undergoing allogeneic hematopoietic cell transplantation. Hernandez Boluda J, Pereira A, Kroeger N, Beelen D, Robin M, Bornhaeuser M, Angelucci E, Vitek A, Blau I, Niittyvuopio R, Finke J, Cornelissen J, Passweg J, Dreger P, Petersen E, Kanz L, Sanz J, Zuckerman T, Zinger N, Iacobelli S, Hayden P, Czerw T, McLornan D, Yakoub-Agha I. Leukemia. 2021 Jan;35(1):215-224. doi: 10.1038/s41375-020-0815-z. PMID: 32286544

Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival. Cabezon M, Malinverni R, Bargay J, Xicoy B, Marce S, Garrido A, Tormo M, Arenillas L, Coll R, Borras J, Jimenez M, Hoyos M, Valcarcel D, Escoda L, Vall-Llovera F, Garcia A, Font L, Ramila E, Buschbeck M, Zamora L, CETLAM Grp. Clinical Epigenetics. 2021 Jan 14;13(1):9. doi: 10.1186/s13148-021-01002-y. PMID: 33446256

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2021 Aug;93(8):5167-5172. doi: 10.1002/jmv.26661. PMID: 33174620

European wide survey on allogeneic haematopoietic cell transplantation practice for myelofibrosis on behalf of the EBMT chronic malignancies working party. McLornan D, Sirait T, Hernandez-Boluda J, Czerw T, Hayden P, Yakoub-Agha I. Current Research in Translational Medicine. 2021 Jan;69(1):103267. doi: 10.1016/j.retram.2020.08.003. PMID: 33069640

Evolving patterns of care and outcomes in relapsed/refractory FLT3 mutated acute myeloid leukemia adult patients. Boluda B, Martinez-Cuadron D, Algarra L, Cano I, Sayas M, Acuna-Cruz E, Blanco A, Marco-Ayala J, DeLapuerta R, Diaz-Gonzalez A, Tormo M, Rodriguez-Veiga R, Garcia R, Pinana J, Lopez-Pavia M, Barragan E, Amigo M, Sargas C, Lopez A, Solana-Altabella A, Gil C, Megias-Vericat J, Sanz M, Montesinos P. Leukemia & Lymphoma. 2021 Nov;62(11):2727-2736. doi: 10.1080/10428194.2021.1938031. PMID: 34121593

Evolving treatment patterns and outcomes in older patients (?60 years) with AML: changing everything to change nothing?. Martinez-Cuadron D, Serrano J, Gil C, Tormo M, Martinez-Sanchez P, Perez-Simon J, Garcia-Boyero R, Rodriguez-Medina C, Lopez-Pavia M, Benavente C, Bergua J, Lavilla-Rubira E, Amigo M, Herrera P, Alonso-Dominguez J, Bernal T, Colorado M, Sayas M, Algarra L, Vidriales M, Rodriguez-Macias G, Vives S, Perez-Encinas M, Lopez A, Noriega V, Garcia-Fortes M, Ramos F, Rodriguez-Gutierrez J, Costilla-Barriga L, Labrador J, Boluda B, Rodriguez-Veiga R, Martinez-Lopez J, Sanz M, Montesinos P. Leukemia. 2021 Jun;35(6):1571-1585. doi: 10.1038/s41375-020-01058-4. PMID: 33077867

Ex vivo T-cell depletion vs post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil as graft-vs-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Montoro J, Roldan E, Pinana J, Barba P, Chorao P, Quintero A, Hernani R, Orti G, Lorenzo J, Balaguer-Rosello A, Salamero O, Fox L, Solves P, Gomez I, Guerreiro M, Boluda J, Sanz G, Solano C, Sanz M, Valcarcel D, Sanz J. European Journal of Haematology. 2021 Jan;106(1):114-125. doi: 10.1111/ejh.13529. PMID: 33025625

Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea. Alvarez-Larran A, Diaz-Gonzalez A, Such E, Mora E, Andrade-Campos M, Garcia-Hernandez C, Gomez-Casares M, Garcia-Gutierrez V, Carreno-Tarragona G, Garrote M, Fernandez-Ibarrondo L, Cervera J, Bellosillo B, Cervantes F, Hernandez-Boluda J, MPN Spanish Group (GEMFIN). Leukemia. 2021 Feb;35(2):623-627. doi: 10.1038/s41375-020-0849-2. PMID: 32372025

High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib. Barbui T, Vannucchi A, Alvarez-Larran A, Iurlo A, Masciulli A, Carobbio A, Ghirardi A, Ferrari A, Rossi G, Elli E, Andrade-Campos M, Kabat M, Kiladjian J, Palandri F, Benevolo G, Garcia-Gutierrez V, Fox M, Foncillas M, Morcillo C, Rumi E, Osorio S, Papadopoulos P, Bonifacio M, Cervantes K, Serrano M, Carreno-Tarragona G, Sobas M, Lunghi F, Patriarca A, Elorza B, Angona A, Mazo E, Koschmieder S, Ruggeri M, Cuevas B, Hernandez-Boluda J, Abadia E, Cirici B, Guglielmelli P, Garrote M, Cattaneo D, Daffini R, Cavalca F, Bellosillo B, Benajiba L, Curto-Garcia N, Bellini M, Betti S, De Stefano V, Harrison C, Rambaldi A. Leukemia. 2021 Feb;35(2):485-493. doi: 10.1038/s41375-020-01107-y. PMID: 33414483

Impact of BCR-ABL1 transcript type on response, treatment-free remission rate and survival in chronic myeloid leukemia patients treated with imatinib. Marce S, Xicoy B, Garcia O, Cabezon M, Estrada N, Velez P, Boque C, Sagues M, Angona A, Teruel-Montoya R, Ferrer-Marin F, Amat P, Hernandez-Boluda J, Ibarra M, Anguita E, Cortes M, Fernandez-Ruiz A, Fontanals S, Zamora L, Grp Espanol Leucemia Mieloide Cron. Journal of Clinical Medicine. 2021 Jul 16;10(14):3146. doi: 10.3390/jcm10143146. PMID: 34300312

Impact of spleen size and splenectomy on outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis: A retrospective analysis by the chronic malignancies working party on behalf of European society for blood and marrow transplantation (EBMT). Polverelli N, Mauff K, Kroger N, Robin M, Beelen D, Beauvais D, Chevallier P, Mohty M, Passweg J, Rubio M, Maertens J, Finke J, Bornhauser M, Vrhovac R, Helbig G, Mear J, Castagna L, Remenyi P, Angelucci E, Karakasis D, Rifon J, Sirait T, Russo D, de Wreede L, Czerw T, Hernandez-Boluda J, Hayden P, McLornan D, Yakoub-Agha I. American Journal of Hematology. 2021 Jan;96(1):69-79. doi: 10.1002/ajh.26020. PMID: 33064301

Kinetics of Torque Teno virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation. Bueno Ferrando F, Albert Vicent E, Pinana J, Perez Martinez A, Ubeda C, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Gimenez Quiles E, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant infectious disease. 2021 Jun;23(3):e13507. doi: 10.1111/tid.13507. PMID: 33176050

Long-term follow-up of recovered MPN patients with COVID-19. Barbui T, Iurlo A, Masciulli A, Carobbio A, Ghirardi A, Rossi G, Harrison C, Alvarez-Larran A, Elli E, Kiladjian J, Kabat M, Sanchez A, Palandri F, Andrade-Campos M, Vannucchi A, Carreno-Tarragona G, Papadopoulos P, Cervantes K, Foncillas M, Fox M, Serrano M, Rumi E, Osorio S, Benevolo G, Patriarca A, Elorza B, Garcia-Gutierrez V, Mazo E, Lunghi F, Bonifacio M, De Stefano V, Hernandez-Boluda J, Abadia E, Angona A, Cirici B, Ruggeri M, Koschmieder S, Sobas M, Cuevas B, Cattaneo D, Daffini R, Bellini M, Curto-Garcia N, Garrote M, Cavalca F, Benajiba L, Bellosillo B, Guglielmelli P, Borsani O, Betti S, Salmoiraghi S, Rambaldi A. Blood Cancer Journal. 2021 Jun 16;11(6):115. doi: 10.1038/s41408-021-00509-0. PMID: 34135309

Measurable residual disease in elderly acute myeloid leukemia: results from the PETHEMA-FLUGAZA phase 3 clinical trial. Simoes C, Paiva B, Martinez-Cuadron D, Bergua J, Vives S, Algarra L, Tormo M, Martinez P, Serrano J, Herrera P, Ramos F, Salamero O, Lavilla E, Gil C, Lopez J, Vidriales M, Labrador J, Falantes J, Sayas M, Ayala R, Martinez-Lopez J, Villar S, Calasanz M, Prosper F, San-Miguel J, Sanz M, Montesinos P. Blood Advances. 2021 Feb 9;5(3):760-770. doi: 10.1182/bloodadvances.2020003195. PMID: 33560390

Myelodysplastic syndromes with 20q deletion: incidence, prognostic value and impact on response to azacitidine of ASXL1 chromosomal deletion and genetic mutations. Martin I, Villamon E, Abellan R, Calasanz M, Irigoyen A, Sanz G, Such E, Mora E, Gutierrez M, Collado R, Garcia-Serra R, Vara M, Blanco M, Oiartzabal I, Alvarez S, Bernal T, Granada I, Xicoy B, Jerez A, Calabuig M, Diez R, Gil A, Diez-Campelo M, Solano C, Tormo M, Spanish Grp Myelodysplastic Syn. British Journal of Haematology. 2021 Aug;194(4):708-717. doi: 10.1111/bjh.17675. PMID: 34296432

Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML Project. Sargas C, Ayala R, Chillon M, Larrayoz M, Carrillo-Cruz E, Bilbao C, Yebenes-Ramirez M, Llop M, Rapado I, Garcia-Sanz R, Vazquez I, Soria E, Florido-Ortega Y, Janusz K, Botella C, Serrano J, Martinez-Cuadron D, Bergua J, Amigo M, Martinez-Sanchez P, Tormo Diaz M, Bernal T, Herrera-Puente P, Garcia R, Algarra L, Sayas M, Costilla-Barriga L, Perez-Santolalla E, Marchante I, Lavilla-Rubira E, Noriega V, Alonso-Dominguez J, Sanz M, Sanchez-Garcia J, Gomez-Casares M, Perez-Simon J, Calasanz M, Gonzalez-Diaz M, Martinez-Lopez J, Barragan E, Montesinos P. Haematologica. 2021 Dec 1;106(12):3079-3089. doi: 10.3324/haematol.2020.263806. PMID: 33179471

Outcome of older (>= 70 years) APL patients frontline treated with or without arsenic trioxide-an International Collaborative Study (vol 34, pg 2333, 2020). Kayser S, Rahme R, Martinez-Cuadron D, Ghiaur G, Thomas X, Sobas M, Guerci-Bresler A, Garrido A, Pigneux A, Gil C, Raffoux E, Tormo M, Vey N, de la Serna J, Salamero O, Lengfelder E, Levis MJ, Fenaux P, Sanz MA, Platzbecker U, Schlenk RF, Ades L, Montesinos P. Leukemia. 2021 Dec;35(12):3631. doi: 10.1038/s41375-021-01358-3. PMID: 34785795

Outcomes and prognostic factors of adults with refractory or relapsed T-cell acute lymphoblastic leukemia included in measurable residual disease-oriented trials. Ribera J, Morgades M, Genesca E, Chapchap E, Montesinos P, Acuna-Cruz E, Gil C, Garcia-Cadenas I, Barba P, Gonzalez-Campos J, de Llano M, Torrent A, Ribera J, Granada I, Bernal T, Diaz-Beya M, Amigo M, Coll R, Tormo M, Vall-llovera F, Gomez-Centurion I, Sanchez-Sanchez M, Soria B, Cladera A, Artola M, Garcia-Guinon A, Gimenez-Conca A, Amador M, Martinez-Sanchez P, Algarra J, Vidal M, Alonso N, Maluquer C, Llorente L, Garcia-Boyero R, Ciudad J, Feliu E, Orfao A, PETHEMA Grp. Hematological Oncology. 2021 Oct;39(4):529-538. doi: 10.1002/hon.2910. PMID: 34405901

Outcomes following second allogeneic haematopoietic cell transplantation in patients with myelofibrosis: a retrospective study of the Chronic Malignancies Working Party of EBMT. Nabergoj M, Mauff K, Robin M, Kroger N, Angelucci E, Poire X, Passweg J, Radujkovic A, Platzbecker U, Robinson S, Rambaldi A, Petersen S, Stolzel F, Stelljes M, Ciceri F, Mayer J, Ladetto M, de Wreede L, Koster L, Hayden P, Czerw T, Hernandez-Boluda J, McLornan D, Chalandon Y, Yakoub-Agha I. Bone Marrow Transplantation. 2021 Aug;56(8):1944-1952. doi: 10.1038/s41409-021-01271-4. PMID: 33824436

Outcomes of patients with chronic myelomonocytic leukaemia treated with non-curative therapies: a retrospective cohort study. Pleyer L, Leisch M, Kourakli A, Padron E, Maciejewski J, Xicoy Cirici B, Kaivers J, Ungerstedt J, Heibl S, Patiou P, Hunter A, Mora E, Geissler K, Dimou M, Jimenez Lorenzo M, Melchardt T, Egle A, Viniou A, Patel B, Arnan M, Valent P, Roubakis C, Bernal Del Castillo T, Galanopoulos A, Calabuig Munoz M, Bonadies N, Medina de Almeida A, Cermak J, Jerez A, Montoro M, Cortes A, Avendano Pita A, Lopez Andrade B, Hellstroem-Lindberg E, Germing U, Sekeres M, List A, Symeonidis A, Sanz G, Larcher-Senn J, Greil R. Lancet. Haematology. 2021 Feb;8(2):e135-e148. doi: 10.1016/S2352-3026(20)30374-4. PMID: 33513373

The mutational landscape of acute myeloid leukaemia predicts responses and outcomes in elderly patients from the PETHEMA-FLUGAZA phase 3 clinical trial. Ayala R, Rapado I, Onecha E, Martinez-Cuadron D, Carreno-Tarragona G, Bergua J, Vives S, Algarra J, Tormo M, Martinez P, Serrano J, Herrera P, Ramos F, Salamero O, Lavilla E, Gil C, Lorenzo J, Vidriales M, Labrador J, Falantes J, Sayas M, Paiva B, Barragan E, Prosper F, Sanz M, Martinez-Lopez J, Montesinos P, PETHEMA Cooperative Study Grp. Cancers. 2021 May 18;13(10):2458. doi: 10.3390/cancers13102458. PMID: 34070172

The risk of thrombosis in essential thrombocythemia is associated with the type of CALR mutation: A multicentre collaborative study. Perez Encinas M, Sobas M, Gomez-Casares M, Abuin Blanco A, Noya Pereira M, Raya J, Andrade-Campos M, Alvarez Larran A, Lewandowki K, Lukasz S, Hernandez Boluda J, Ferrer-Marin F, Fox M, Golos A, Gasior Kabat M, Magro Mazo E, Czyz A, Martin Martin A, Bellosillo Paricio B, Quinteiro Garcia C, Gonzalez Martin J, Stuckey R. European Journal of Haematology. 2021 Mar;106(3):371-379. doi: 10.1111/ejh.13561. PMID: 33275803

The safety and efficacy of dasatinib plus nivolumab in patients with previously treated chronic myeloid leukemia: results from a phase 1b dose-escalation study. Martinez-Lopez J, Mustjoki S, Porkka K, Klisovic R, Wolf D, Busque L, Hernandez-Boluda J, Swanink R, Regueira P, Lipton J. Leukemia & Lymphoma. 2021 Aug;62(8):2040-2043. doi: 10.1080/10428194.2021.1889536. PMID: 33653205

Trends in allogeneic haematopoietic cell transplantation for myelofibrosis in Europe between 1995 and 2018: a CMWP of EBMT retrospective analysis. McLornan D, Eikema DJ, Czerw T, Kroger N, Koster L, Reinhardt HC, Angelucci E, Robin M, Bornhauser M, Passweg J, Clark A, Vydra J, Blau IE, Niittyvuopio R, Platzbecker U, Cornelissen JJ, Chevallier P, Srour M, Stamatovic D, Martinez-Lopez J, de Wreede L, Hayden P, Hernandez-Boluda JC, Yakoub-Agha I.Bone Marrow Transplantation. 2021 Sep;56(9):2160-2172. doi: 10.1038/s41409-021-01305-x. PMID: 33911203

Unmet clinical needs in the management of CALR-mutated essential thrombocythaemia: a consensus-based proposal from the European LeukemiaNet. Alvarez-Larran A, Sant’Antonio E, Harrison C, Kiladjian J, Griesshammer M, Mesa R, Ianotto J, Palandri F, Hernandez-Boluda J, Birgegard G, Nangalia J, Koschmieder S, Rumi E, Barbui T. Lancet Haematology. 2021 Sep;8(9):e658-e665. doi: 10.1016/S2352-3026(21)00204-0. PMID: 34450103

A pediatric regimen for adolescents and young adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: Results of the ALLRE08 PETHEMA trial. Ribera J, Morgades M, Montesinos P, Tormo Diaz M, Martinez-Carballeira D, Gonzalez-Campos J, Gil C, Barba P, Garcia-Boyero R, Coll R, Pedreno M, Ribera J, Mercadal S, Vives S, Novo A, Genesca E, Hernandez-Rivas J, Bergua J, Amigo M, Vall-Llovera F, Martinez-Sanchez P, Calbacho M, Garcia-Cadenas I, Garcia-Guinon A, Sanchez-Sanchez M, Cervera M, Feliu E, Orfao A, Spanish Soc Hematology. Cancer Medicine. 2020 Apr;9(7):2317-2329. doi: 10.1002/cam4.2814. PMID: 32022463

Acute myeloid leukemia with NPM1 mutation and favorable European LeukemiaNet category: outcome after preemptive intervention based on measurable residual disease. Bataller A, Onate G, Diaz-Beya M, Guijarro F, Garrido A, Vives S, Tormo Diaz M, Arnan M, Salamero O, Sampol A, Coll R, Vall-Llovera F, Oliver-Caldes A, Lopez-Guerra M, Pratcorona M, Zamora L, Villamón Ribate E, Rou G, Blanco A, Nomdedeu J, Colomer D, Brunet S, Sierra J, Esteve J, Grp Cooperativo Estudio Tratamient. British Journal of Haematology. 2020 Oct;191(1):52-61. doi: 10.1111/bjh.16857. PMID: 32510599

An investigation of the utility of plasma Cytomegalovirus (CMV) microRNA detection to predict CMV DNAemia in allogeneic hematopoietic stem cell transplant recipients. Talaya Peñalver A, Gimenez Quiles E, Pascual M, Gago B, Piñana Sanchez J, Hernandez Boluda J, Vazquez L, Garcia M, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Medical Microbiology And Immunology. 2020 Feb;209(1):15-21. doi: 10.1007/s00430-019-00632-7. PMID: 31478067

Application of a digital PCR method for WT1 to myeloid neoplasms in CR and deep ELN WT1 molecular response (< 10 copies). Bussaglia E, Pratcorona M, Carricondo M, Sansegundo L, Rubio M, Monter A, Brell A, Badell I, Esteve J, Arnan M, Talarn C, Tormo Diaz M, Garcia A, Vall-Llovera F, Ortin X, Pedro C, Bargay J, Brunet S, Sierra J, Nomdedeu J. Annals of Hematology. 2020 Apr;99(4):765-772. doi: 10.1007/s00277-020-03910-0. PMID: 32062741

Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell transplantation. Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Hernandez Boluda J, Gimenez Quiles E, Gomez M, Balaguer-Rosello A, Gonzalez-Barbera E, Guerreiro M, Aguilar C, Navarro Ortega D, Solano Vercet C, Sanz J, Luis Pinana J. Transplant Infectious Disease. 2020 Aug;22(4):e13301. doi: 10.1111/tid.13301. PMID: 32363665

Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols. Sobas M, Rodriguez-Veiga R, Vellenga E, Paluszewska M, De la Serna J, Garcia-Alvarez F, Gil C, Brunet S, Bergua J, Gonzalez-Campos J, Ribera J, Tormo Diaz M, Gonzalez M, Fernandez I, Benavente C, Gonzalez-Sanmiguel J, Esteve J, Perez-Encinas M, Salamero O, Manso F, Lowenberg B, Sanzs M, Montesinos P, PETHEMA H. European Journal of Haematology. 2020 Mar;104(3):162-169. doi: 10.1111/ejh.13346. PMID: 31724208

Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens. Luis Pinana J, Albert Vicent E, Dolores Gomez M, Perez Martinez A, Hernandez Boluda J, Montoro J, Salavert M, Maria Gonzalez E, Tormo Diaz M, Gimenez Quiles E, Villalba M, Balaguer-Rosello A, Hernani Morales R, Bueno Ferrando F, Borras Salvador R, Sanz J, Solano Vercet C, Navarro Ortega D. The Journal of infection. 2020 May;80(5):578-606. doi: 10.1016/j.jinf.2020.01.001. PMID: 31926954

Clinico-biological characteristics of patients with myelofibrosis: an analysis of 1,000 cases from the Spanish Registry of Myelofibrosis. Pastor Galan I, Hernandez Boluda J, Correa J, Alvarez-Larran A, Ferrer-Marin F, Raya J, Ayala R, Velez P, Perez-Encinas M, Estrada N, Garcia-Gutierrez V, Fox M, Payer A, Kerguelen A, Cuevas B, Duran M, Ramirez M, Gomez-Casares M, Mata-Vazquez M, Mora E, Martinez-Valverde C, Arbelo E, Angona A, Magro E, Antelo M, Somolinos N, Cervantes F, Grupo Espanol De Enfermedades Mieloproliferativas Filadelf. Medicina Clinica. 2020 Aug 28;155(4):152-158. doi: 10.1016/j.medcli.2019.11.007. PMID: 31980217

Corrigendum to «Performance of prognostic scoring systems in elderly patients with acute myeloid leukaemia on intensive chemotherapy: A PETHEMA registry study» [Leuk. Res. 92 (March) (2020) 106352. Rodríguez-Medina C, Martínez-Cuadrón D, Cano I, Gil C, Tormo Diaz M, Del Pilar Martínez-Sánchez M, Del Castillo T, Serrano-López J, Benavente C, Herrera-Puente P, García-Boyero R, Lavilla-Rubira E, Luz Amigo M, Sayas-Lloris M, Bergua-Burgues J, Pérez-Simón J, Rodríguez G, Espadana A, Vidriales-Vicente B, Fernández R, López-Lorenzo J, López M, García-Fortes M, Gómez J, Colorado-Araujo M, Sossa-Melo C, Aguilar E, Montesinos P. Leukemia Research. 2020 Sep;96:106388. doi: 10.1016/j.leukres.2020.106388. PMID: 32680618

Current Treatment Options for Chronic Myeloid Leukemia Patients Failing Second-Generation Tyrosine Kinase Inhibitors. Garcia-Gutierrez V, Hernandez Boluda J. Journal of Clinical Medicine. 2020 Jul 15;9(7):2251. doi: 10.3390/jcm9072251. PMID: 32679880

Cytomegalovirus DNA load monitoring in stool specimens for anticipating the occurrence of intestinal acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: Is it of any value?. Bueno Ferrando F, Albert Vicent E, Gimenez Quiles E, Pinana J, Perez Martinez A, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Aug 9;e13440. doi: 10.1111/tid.13440. PMID: 32772456

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Feasibility of thiotepa addition to the fludarabine-busulfan conditioning with tacrolimus/sirolimus as graft vs host disease prophylaxis. Fox M, Garcia-Cadenas I, Perez Martinez A, Villacampa G, Pinana J, Orti G, Montoro J, Roldan E, Bosch Vilaseca A, Martino R, Salamero O, Saavedra S, Hernandez Boluda J, Esquirol A, Sierra J, Sanz J, Solano Vercet C, Bosch F, Barba P, Valcarcel D. Leukemia & Lymphoma. 2020 Aug;61(8):1823-1832. doi: 10.1080/10428194.2020.1788015. PMID: 32654570

Features of Cytomegalovirus DNAemia Blips in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Implications for Optimization of Preemptive Antiviral Therapy Strategies. Huntley Pascual D, Talaya Peñalver A, Gimenez Quiles E, Perez Martinez A, Hernandez Boluda J, Hernani Morales R, Torres Fink I, Alberola J, Albert Vicent E, Piñana Sanchez J, Solano Vercet C, Navarro Ortega D. Biology of Blood and Marrow Transplantation. 2020 May;26(5):972-977. doi: 10.1016/j.bbmt.2020.01.015. PMID: 32007638

Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium. Sanchez-Maldonado J, Campa D, Springer J, Badiola J, Niazi Y, Moniz-Diez A, Hernandez-Mohedo F, Gonzalez-Sierra P, Ter Horst R, Macauda A, Brezina S, Cunha C, Lackner M, Lopez-Nevot M, Fianchi L, Pagano L, Lopez-Fernandez E, Potenza L, Luppi M, Moratalla L, Rodriguez-Sevilla J, Fonseca J, Tormo Diaz M, Solano Vercet C, Clavero E, Romero A, Li Y, Lass-Florl C, Einsele H, Vazquez L, Loeffler J, Hemminki K, Carvalho A, Netea M, Gsur A, Dumontet C, Canzian F, Forsti A, Jurado M, Sainz J. Blood Cancer Journal. 2020 Jul 16;10(7):75. doi: 10.1038/s41408-020-00341-y. PMID: 32678078

Impact of clinical features, cytogenetics, genetic mutations, and methylation dynamics of CDKN2B and DLC-1 promoters on treatment response to azacitidine. Martin Gonzalez I, Navarro Cubells B, Serrano Alcalá A, Villamón Ribate E, Calabuig Muñoz M, Solano Vercet C, Chaves Martínez F, Yague N, Orts M, Amat Martínez P, Fuentes Trillo A, Seda García E, García García F, Hernandez Boluda J, Tormo Diaz M. Annals of Hematology. 2020 Mar;99(3):527-537. doi: 10.1007/s00277-020-03932-8. PMID: 31989250

Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with post-transplantation cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Jesus Pascual M, Hernandez Boluda J, Gago B, Vazquez Lopez L, Luis Pinana J, Garcia M, Perez Martinez A, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Feb;22(1):e13206. doi: 10.1111/tid.13206. PMID: 31677215

Management of hyperleukocytosis and impact of leukapheresis among patients with acute myeloid leukemia (AML) on short- and long-term clinical outcomes: a large, retrospective, multicenter, international study. Stahl M, Shallis R, Wei W, Montesinos P, Lengline E, Neukirchen J, Bhatt V, Sekeres M, Fathi A, Konig H, Luger S, Khan I, Roboz G, Cluzeau T, Martinez-Cuadron D, Raffoux E, Germing U, Umakanthan J, Mukherjee S, Brunner A, Miller A, McMahon C, Ritchie E, Rodriguez-Veiga R, Itzykson R, Boluda B, Rabian F, Tormo Diaz M, Acuna-Cruz E, Rabinovich E, Yoo B, Cano I, Podoltsev N, Bewersdorf J, Gore S, Zeidan A. Leukemia. 2020 Dec;34(12):3149-3160. doi: 10.1038/s41375-020-0783-3. PMID: 32132655

miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk. Ferrer-Marin F, Arroyo A, Bellosillo B, Cuenca E, Zamora L, Hernandez-Rivas J, Hernandez Boluda J, Fernandez-Rodriguez C, Luno E, Garcia Hernandez C, Kerguelen A, Fiallo-Suarez D, Gomez-Casares M, Ayala R, Velez P, Boque C, Garcia-Gutierrez V, Arrizabalaga B, Estrada N, Cifuentes R, Arcas I, de los Reyes-Garcia A, Besses C, Vicente V, Alvarez-Larran A, Teruel-Montoya R, Gonzalez-Conejero R, Martinez C, GEMFIN Grp. Leukemia. 2020 Oct;34(10):2648-2659. doi: 10.1038/s41375-020-0767-3. PMID: 32107471

Natural history of polycythemia vera and essential thrombocythemia presenting with splanchnic vein thrombosis. Alvarez-Larran A, Pereira A, Magaz M, Hernandez Boluda J, Garrote M, Cuevas B, Ferrer-Marin F, Teresa Gomez-Casares M, Garcia-Gutierrez V, Isabel Mata-Vazquez M, Turon F, Hernandez-Gea V, Arellano-Rodrigo E, Cervantes F, Carlos Garcia-Pagan J, GEMFIN Grp, REHEVASC Grp. Annals of Hematology. 2020 Apr;99(4):791-798. doi: 10.1007/s00277-020-03965-z. PMID: 32086587

Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT. McLornan D, Malpassuti V, Lippinkhof-Kozijn A, Potter V, Beelen D, Bunjes D, Sengeloev H, Radujkovic A, Passweg J, Chalandon Y, Kroeger N, Wulf G, Johansson J, Ciceri F, Bornhaeuser M, Holler E, Guffroy B, Martin S, Neubauer A, Gramatski M, Robin M, Iacobelli S, Hayden P, Hernandez Boluda J, Czerw T, Yakoub-Agha I. British Journal of Haematology. 2020 Aug;190(3):437-441. doi: 10.1111/bjh.16537. PMID: 32108327

Outcome of older (>= 70 years) APL patients frontline treated with or without arsenic trioxide-an International Collaborative Study. Kayser S, Rahme R, Martinez-Cuadron D, Ghiaur G, Thomas X, Sobas M, Guerci-Bresler A, Garrido A, Pigneux A, Gil C, Raffoux E, Tormo Diaz M, Vey N, de la Serna J, Salamero O, Lengfelder E, Levis M, Fenaux P, Sanz M, Platzbecker U, Schlenk R, Ades L, Montesinos P. Leukemia. 2020 Sep;34(9):2333-2341. doi: 10.1038/s41375-020-0758-4.PMID: 32076120

Patterns of care and clinical outcomes of patients with newly diagnosed acute myeloid leukemia presenting with hyperleukocytosis who do not receive intensive chemotherapy. Shallis R, Stahl M, Wei W, Montesinos P, Lengline E, Neukirchen J, Bhatt V, Sekeres M, Fathi A, Konig H, Luger S, Khan I, Roboz G, Cluzeau T, Martinez-Cuadron D, Raffoux E, Germing U, Umakanthan J, Mukhereje S, Brunner A, Miller A, McMahon C, Ritchie E, Rodriguez-Veiga R, Itzykson R, Boluda B, Rabian F, Tormo Diaz M, Cruz E, Rabinovich E, Yoo B, Cano I, Podoltsev N, Bewersdorf J, Gore S, Zeidan A. Leukemia & Lymphoma. 2020 May;61(5):1220-1225. doi: 10.1080/10428194.2020.1728753. PMID: 32100599

Performance of prognostic scoring systems in elderly patients with acute myeloid leukaemia on intensive chemotherapy: A PETHEMA registry study. Rodriguez-Medina C, Martinez-Cuadron D, Cano I, Gil C, Tormo Diaz M, Del Pilar Martinez-Sanchez M, Del Castillo T, Serrano-Lopez J, Benavente C, Herrera-Puente P, Garcia-Boyero R, Lavilla-Rubira E, Amigo M, Sayas-Lloris M, Bergua-Burgues J, Perez-Simon J, Rodriguez G, Espadana A, Vidriales-Vicente B, Fernandez R, Lopez-Lorenzo J, Lopez M, Garcia-Fortes M, Labrador Gomez J, Colorado-Araujo M, Sossa-Melo C, Aguilar E, Montesinos Fernandez P. Leukemia Research. 2020 Mar 23;92:106352. doi: 10.1016/j.leukres.2020.106352. PMID: 32240863

Peripheral blood regulatory T cells and occurrence of Cytomegalovirus DNAemia after unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Vázquez L, Amat Martínez P, Remigia Pellicer M, Hernández M, Hernandez Boluda J, Gago B, Piñana Sanchez J, García M, Perez Martinez A, Alberola J, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1493-1496. doi: 10.1038/s41409-020-0950-1. PMID: 32447351

Predicting Survival after Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis: Performance of the Myelofibrosis Transplant Scoring System (MTSS) and Development of a New Prognostic Model: Prognostication in myelofibrosis. Hernandez Boluda J, Pereira A, Alvarez-Larran A, Martin A, Benzaquen Vallejos A, Aguirre L, Mora E, Gonzalez P, Mora J, Dorado N, Sampol A, Garcia-Gutierrez V, Lopez-Godino O, Fox M, Reguera J, Perez-Encinas M, Pascual M, Xicoy B, Parody R, Gonzalez-Pinedo L, Espanol I, Avendano A, Correa J, Vallejo C, Jurado M, Garcia-Cadenas I, Osorio S, Duran M, Sanchez-Guijo F, Cervantes F, Pinana J. Biology of Blood and Marrow Transplantation. 2020 Dec;26(12):2237-2244. doi: 10.1016/j.bbmt.2020.07.022. PMID: 32717433

Prospective Randomized Study Comparing Myeloablative Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Stem Cell Transplantation for Adults with Hematologic Malignancies. Sanz J, Montoro J, Solano Vercet C, Valcarcel D, Sampol A, Ferra C, Parody R, Lorenzo I, Montesinos P, Orti G, Hernandez Boluda J, Balaguer-Rosello A, Guerreiro M, Carretero C, Sanz G, Sanz M, Pinana J. Biology of Blood and Marrow. 2020 Feb;26(2):358-366. doi: 10.1016/j.bbmt.2019.10.014. PMID: 31655119

Reconstitution of cytomegalovirus-specific T-cell immunity following unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Remigia Pellicer M, Amat Martínez P, Vazquez Lopez L, Hernandez M, Hernandez Boluda J, Gago B, Piñana Sanchez J, Garcia M, Perez Martinez A, Mateo Jimenez E, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1347-1356. doi: 10.1038/s41409-020-0865-x. PMID: 32205853

Scute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2). study of 61 patients treated with intensive protocols.. Sitges M, Boluda B, Garrido A, Morgades M, Granada I, Barragan E, Arnan M, Serrano J, Tormo Diaz M, Miguel Bergua J, Colorado M, Salamero O, Esteve J, Benavente C, Perez-Encinas M, Coll R, Marti-Tutusaus J, Brunet S, Sierra J, Angel Sanz M, Montesinos P, Ribera J, Vives S, PETHEMA C. European Journal of Haematology. 2020 Aug;105(2):138-147. doi: 10.1111/ejh.13417. PMID: 32243655

Severe thrombocytopenia in myelofibrosis is more prevalent than previously reported Masarova L, Mesa R, Hernandez Boluda J, Taylor J. Leukemia Research. 2020 Apr;91:106338. doi: 10.1016/j.leukres.2020.106338. PMID: 32200188

The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey. Pinana J, Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Gimenez Quiles E, Gomez M, Guerreiro M, Gonzalez-Barbera E, Carretero C, Salavert M, Balaguer-Rosello A, Sanz G, Hernandez Boluda J, Solano Vercet C, Sanz J, Navarro Ortega D. Bone Marrow Transplantation. 2020 Feb;55(2):431-440. doi: 10.1038/s41409-019-0698-7. PMID: 31551521

Treatment of Frail Older Adults and Elderly Patients With Philadelphia Chromosome-negative Acute Lymphoblastic Leukemia: Results of a Prospective Trial With Minimal Chemotherapy. Ribera J, Garcia O, Chapchap E, Gil C, Gonzalez-Campos J, Barba P, Amigo M, Moreno M, Lavilla E, Alonso N, Bergua J, Tormo Diaz M, Ribera J, Sierra M, Martinez-Carballeira D, Mercadal S, Hernandez-Rivas J, Vall-Llovera F, Genesca E, Cladera A, Novo A, Abella E, Garcia-Cadenas I, Monteserin C, Bermudez A, Piernas S, Montesinos P, Lopez J, Garcia-Guinon A, Serrano A, Martinez M, Olivares M, Lopez A, Serrano J, PETHEMA Group S. Clinical Lymphoma, Myeloma & Leukemia. 2020 Aug;20(8):e513-e522. doi: 10.1016/j.clml.2020.03.011. PMID: 32336676

UGT1A1 genotype influences clinical outcome in patients with intermediate-risk acute myeloid leukemia treated with cytarabine-based chemotherapy. Diaz-Santa J, Rodriguez-Romanos R, Osca G, Pratcorona M, Garrido A, Coll R, Moret C, Escoda L, TORMO DIAZ M, Heras I, Arnan M, Vives S, Salamero O, Lloveras N, Bargay J, Sampol A, Cruz D, Garcia A, Quinones T, Esteve J, Sierra J, Gallardo D, on the behalf of CETLAM Group. Leukemia. 2020 Nov;34(11):2925-2933. doi: 10.1038/s41375-020-0784-2. PMID: 32152464

Uniform graft-versus-host disease prophylaxis with posttransplant cyclophosphamide, sirolimus, and mycophenolate mofetil following hematopoietic stem cell transplantation from haploidentical, matched sibling and unrelated donors. Montoro J, Pinana J, Hernandez Boluda J, Hernani Morales R, Lorenzo I, Perez Martinez A, Guerreiro M, Balaguer-Rosello A, Sanz G, Carretero C, Albert Vicent E, Navarro Ortega D, Sanz M, Solano Vercet C, Sanz J. Bone Marrow Transplantation. 2020 Nov;55(11):2147-2159. doi: 10.1038/s41409-020-0921-6. PMID: 32371901

Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia. Genesca E, Morgades M, Montesinos P, Barba P, Gil C, Guardia R, Moreno M, Martinez-Carballeira D, Garcia-Cadenas I, Vives S, Ribera J, Gonzalez-Campos J, Gonzalez-Gil C, Zamora L, Ramirez J, Diaz-Beya M, Mercadal S, Artola M, Cladera A, Tormo Diaz M, Bermudez A, Vall-Llovera F, Martinez P, Amigo M, Monsalvo S, Novo A, Cervera M, Garcia-Guinon A, Junca J, Ciudad J, Orfao A, Ribera J. Haematologica. 2020 Jun;105(6):e294-e297. doi: 10.3324/haematol.2019.225078. PMID: 31537688

Proyectos
Referencia: PI21/00538
Título: Factores clinicobiológicos y genéticos asociados al riesgo de trombosis en la mielofibrosis
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Juan Carlos Hernández Boluda
Duración: 2022 – 2024
Presupuesto: 96.800 €
El objetivo del proyecto es analizar los factores clínico-hematológicos y genéticos asociados al riesgo de trombosis en la mielofibrosis (enfermedad rara que afecta a las células madre de la médula ósea), así como su secuenciación por NGS (Next Generation Sequencing) de los cuatro centros participantes en el proyecto coordinado para evaluar el impacto del perfil molecular en el riesgo de trombosis en la MF.
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Título: Rol del complejo RUNX1-CBF-Β/HIPK2/p300/p53 en la evolución leucémica de las neoplasias mieloproliferativas crónicas
Doctorando: Lozano Asencio, Carlos Alberto
Director: Hernández Boluda, Juan Carlos; Climent Bataller, Joan
Fecha: 14/02/2020
Universidad: Universitat de València

Título: Caracterización molecular de la anemia refractaria con sideroblastos en anillo mediante un panel de secuenciación de segunda generación
Doctorando: Martín Castillo, Iván
Director: Sanz Alonso, Miguel Ángel; Such Taboada, Esperanza; Cervera Zamora, Jose Vicente
Fecha: 06/02/2020
Universidad: Universitat de València

Título: Análisis de la relación coste-efectividad del tratamiento con azacitidina en pacientes con síndrome mielodisplásico en el hospital clínico universitario de valencia
Doctorando: Torrecilla Junyent, Teresa
Director: Alós Almiñana, Manuel; Tormo Díaz, María del Mar; Cortijo Gimeno, Julio
Fecha: 12/06/2019
Universidad: Universitat de València