Grupo de investigación en neoplasias de línea mieloide

Área de Oncología

Caracterización molecular NGS en pacientes con trombocitemia esencial o policitemia vera que desarrollan resistencia a hidroxicarbamida

Analizar el impacto de mutaciones genéticas y regulación epigenética en la respuesta al fármaco hipometilante azacitidina

Analizar pacientes diagnosticados con síndromes mielodisplásicos con deleción 20q y del (20q). Evaluar la incidencia, el valor pronóstico y el impacto en la respuesta a la azacitidina de las alteraciones cromosómicas ASXL1 y otras mutaciones genéticas

Coordinador
Dra. Mar Tormo Díaz
maria.mar.tormo@uv.es; tormo_mar@gva.es

INVESTIGADORES
R4 Senior

Juan Carlos Hernández Boluda
Mar Tormo Díaz    

R3 Consolidado
R2 Novel / Emergente

Carlos Carretero Márquez
Iván Martín Castillo
Marisa Calabuig Muñoz
Montserrat Gómez Calafat

R1 Predoctoral

Irene Pastor Galán

STAFF
Colaborador/a

Eva Villamón Ribate

Enfermero/a

Alicia Borrero Abarca

Técnico/a
Apoyo
Publicaciones
A phase 3 trial of azacitidine versus a semi-intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia. Vives S, Martinez-Cuadron D, Bergua Burgues J, Algarra L, Tormo M, Martinez-Sanchez M, Serrano J, Herrera P, Ramos F, Salamero O, Lavilla E, Lopez-Lorenzo J, Gil C, Vidriales B, Falantes J, Serrano A, Labrador J, Sayas M, Foncillas M, Amador Barciela M, Olave M, Colorado M, Gascon A, Fernandez M, Simiele A, Perez-Encinas M, Rodriguez-Veiga R, Garcia O, Martinez-Lopez J, Barragan E, Paiva B, Sanz M, Montesinos P, PETHEMA Group. CANCER. 2021 Feb 24. doi: 10.1002/cncr.33403. PMID: 33626197

An investigation of the potential association between gastrointestinal viral and bacterial infection and development of intestinal acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. Bueno F, Albert E, Gimenez E, Pinana J, Perez A, Gomez M, Hernandez-Boluda J, Gonzalez-Barbera E, Montoro J, Buesa J, Guerreiro M, Balaguer-Rosello A, Hernani R, Sanz J, Solano C, Navarro D. Journal of Medical Virology. 2021 Feb 19. doi: 10.1002/jmv.26892. PMID: 33605457

Chemotherapy or Allogeneic Transplantation in High-Risk Philadelphia Chromosome-Negative Adult Lymphoblastic Leukemia. Ribera J, Morgades M, Ciudad J, Montesinos P, Esteve J, Genesca E, Barba P, Ribera J, Garcia Cadenas I, Moreno M, Martinez-Carballeira D, Torrent A, Martinez-Sanchez P, Monsalvo S, Gil C, Tormo M, Artola M, Cervera M, Gonzalez-Campos J, Rodriguez-Medina C, Bermudez A, Novo A, Soria B, Coll R, Amigo M, Lopez A, Fernandez Martin R, Serrano J, Mercadal S, Cladera A, Gimenez-Conca A, Penarrubia M, Abella E, Vall-Llovera F, Hernandez-Rivas J, Garcia A, Bergua Burgues J, de Rueda B, Sanchez-Sanchez M, Serrano A, Calbacho M, Alonso Vence N, Mendez-Sanchez J, Garcia-Boyero R, Olivares M, Barrena S, Zamora L, Granada I, Lhermitte L, Feliu E, Orfao A. Blood. 2021 Apr 8;137(14):1879-1894. doi: 10.1182/blood.2020007311. PMID: 33150388

Cytoreductive treatment in patients withCALR-mutated essential thrombocythaemia: a study comparing indications and efficacy among genotypes from the Spanish Registry of Essential Thrombocythaemia. Alvarez-Larran A, Angona A, Andrade-Campos M, Soledad Noya M, Teresa Gomez-Casares M, Cuevas B, Caballero G, Garcia-Hernandez C, Garcia-Gutierrez V, Palomino A, Ferrer-Marin F, Isabel Mata-Vazquez M, Moreto A, Magro E, Murillo I, Alonso-Dominguez J, Maria Guerra J, Guerrero L, Maria Raya J, Perez-Encinas M, Carreno-Tarragona G, Fox L, Pastor Galan I, Bellosillo B, Hernandez Boluda J, MPN Spanish Grp Gemfin. British Journal of Haematology. 2021 Mar;192(6):988-996. doi: 10.1111/bjh.16988. PMID: 32745264

Determinants of survival in myelofibrosis patients undergoing allogeneic hematopoietic cell transplantation. Hernandez Boluda J, Pereira A, Kroeger N, Beelen D, Robin M, Bornhaeuser M, Angelucci E, Vitek A, Blau I, Niittyvuopio R, Finke J, Cornelissen J, Passweg J, Dreger P, Petersen E, Kanz L, Sanz J, Zuckerman T, Zinger N, Iacobelli S, Hayden P, Czerw T, McLornan D, Yakoub-Agha I. Leukemia. 2021 Jan;35(1):215-224. doi: 10.1038/s41375-020-0815-z. PMID: 32286544

Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival. Cabezon M, Malinverni R, Bargay J, Xicoy B, Marce S, Garrido A, Tormo M, Arenillas L, Coll R, Borras J, Jimenez M, Hoyos M, Valcarcel D, Escoda L, Vall-Llovera F, Garcia A, Font L, Ramila E, Buschbeck M, Zamora L, CETLAM Grp. Clinical Epigenetics. 2021 Jan 14;13(1):9. doi: 10.1186/s13148-021-01002-y. PMID: 33446256

European wide survey on allogeneic haematopoietic cell transplantation practice for myelofibrosis on behalf of the EBMT chronic malignancies working party. McLornan D, Sirait T, Hernandez-Boluda J, Czerw T, Hayden P, Yakoub-Agha I. Current Research in Translational Medicine. 2021 Jan;69(1):103267. doi: 10.1016/j.retram.2020.08.003. PMID: 33069640

Ex vivo T-cell depletion vs post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil as graft-vs-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Montoro J, Roldan E, Pinana J, Barba P, Chorao P, Quintero A, Hernani R, Orti G, Lorenzo J, Balaguer-Rosello A, Salamero O, Fox L, Solves P, Gomez I, Guerreiro M, Boluda J, Sanz G, Solano C, Sanz M, Valcarcel D, Sanz J. European Journal of Haematology. 2021 Jan;106(1):114-125. doi: 10.1111/ejh.13529. PMID: 33025625

Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea. Alvarez-Larran A, Diaz-Gonzalez A, Such E, Mora E, Andrade-Campos M, Garcia-Hernandez C, Gomez-Casares M, Garcia-Gutierrez V, Carreno-Tarragona G, Garrote M, Fernandez-Ibarrondo L, Cervera J, Bellosillo B, Cervantes F, Hernandez Boluda J, MPN Spanish Group (GEMFIN). Leukemia. 2021 Feb;35(2):623-627. doi: 10.1038/s41375-020-0849-2. PMID: 32372025

High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib. Barbui T, Vannucchi A, Alvarez-Larran A, Iurlo A, Masciulli A, Carobbio A, Ghirardi A, Ferrari A, Rossi G, Elli E, Andrade-Campos M, Kabat M, Kiladjian J, Palandri F, Benevolo G, Garcia-Gutierrez V, Fox M, Foncillas M, Morcillo C, Rumi E, Osorio S, Papadopoulos P, Bonifacio M, Cervantes K, Serrano M, Carreno-Tarragona G, Sobas M, Lunghi F, Patriarca A, Elorza B, Angona A, Mazo E, Koschmieder S, Ruggeri M, Cuevas B, Hernandez-Boluda J, Abadia E, Cirici B, Guglielmelli P, Garrote M, Cattaneo D, Daffini R, Cavalca F, Bellosillo B, Benajiba L, Curto-Garcia N, Bellini M, Betti S, De Stefano V, Harrison C, Rambaldi A. Leukemia. 2021 Feb;35(2):485-493. doi: 10.1038/s41375-020-01107-y. PMID: 33414483

Impact of spleen size and splenectomy on outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis: A retrospective analysis by the chronic malignancies working party on behalf of European society for blood and marrow transplantation (EBMT). Polverelli N, Mauff K, Kroger N, Robin M, Beelen D, Beauvais D, Chevallier P, Mohty M, Passweg J, Rubio M, Maertens J, Finke J, Bornhauser M, Vrhovac R, Helbig G, Mear J, Castagna L, Remenyi P, Angelucci E, Karakasis D, Rifon J, Sirait T, Russo D, de Wreede L, Czerw T, Hernandez-Boluda J, Hayden P, McLornan D, Yakoub-Agha I. American Journal of Hematology. 2021 Jan;96(1):69-79. doi: 10.1002/ajh.26020. PMID: 33064301

Measurable residual disease in elderly acute myeloid leukemia: results from the PETHEMA-FLUGAZA phase 3 clinical trial. Simoes C, Paiva B, Martinez-Cuadron D, Bergua J, Vives S, Algarra L, Tormo M, Martinez P, Serrano J, Herrera P, Ramos F, Salamero O, Lavilla E, Gil C, Lopez J, Vidriales M, Labrador J, Falantes J, Sayas M, Ayala R, Martinez-Lopez J, Villar S, Calasanz M, Prosper F, San-Miguel J, Sanz M, Montesinos P. Blood Advances. 2021 Feb 9;5(3):760-770. doi: 10.1182/bloodadvances.2020003195. PMID: 33560390

Outcomes of patients with chronic myelomonocytic leukaemia treated with non-curative therapies: a retrospective cohort study. Pleyer L, Leisch M, Kourakli A, Padron E, Maciejewski J, Xicoy Cirici B, Kaivers J, Ungerstedt J, Heibl S, Patiou P, Hunter A, Mora E, Geissler K, Dimou M, Jimenez Lorenzo M, Melchardt T, Egle A, Viniou A, Patel B, Arnan M, Valent P, Roubakis C, Bernal Del Castillo T, Galanopoulos A, Calabuig Munoz M, Bonadies N, Medina de Almeida A, Cermak J, Jerez A, Montoro M, Cortes A, Avendano Pita A, Lopez Andrade B, Hellstroem-Lindberg E, Germing U, Sekeres M, List A, Symeonidis A, Sanz G, Larcher-Senn J, Greil R. Lancet. Haematology. 2021 Feb;8(2):e135-e148. doi: 10.1016/S2352-3026(20)30374-4. PMID: 33513373

The risk of thrombosis in essential thrombocythemia is associated with the type of CALR mutation: A multicentre collaborative study. Perez Encinas M, Sobas M, Gomez-Casares M, Abuin Blanco A, Noya Pereira M, Raya J, Andrade-Campos M, Alvarez Larran A, Lewandowki K, Lukasz S, Hernandez Boluda J, Ferrer-Marin F, Fox M, Golos A, Gasior Kabat M, Magro Mazo E, Czyz A, Martin Martin A, Bellosillo Paricio B, Quinteiro Garcia C, Gonzalez Martin J, Stuckey R. European Journal of Haematology. 2021 Mar;106(3):371-379. doi: 10.1111/ejh.13561. PMID: 33275803

The safety and efficacy of dasatinib plus nivolumab in patients with previously treated chronic myeloid leukemia: results from a phase 1b dose-escalation study. Martinez-Lopez J, Mustjoki S, Porkka K, Klisovic R, Wolf D, Busque L, Hernandez-Boluda J, Swanink R, Regueira P, Lipton J. Leukemia & Lymphoma. 2021 Mar 2;1-7. doi: 10.1080/10428194.2021.1889536. PMID: 33653205

A pediatric regimen for adolescents and young adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: Results of the ALLRE08 PETHEMA trial. Ribera J, Morgades M, Montesinos P, Tormo Diaz M, Martinez-Carballeira D, Gonzalez-Campos J, Gil C, Barba P, Garcia-Boyero R, Coll R, Pedreno M, Ribera J, Mercadal S, Vives S, Novo A, Genesca E, Hernandez-Rivas J, Bergua J, Amigo M, Vall-Llovera F, Martinez-Sanchez P, Calbacho M, Garcia-Cadenas I, Garcia-Guinon A, Sanchez-Sanchez M, Cervera M, Feliu E, Orfao A, Spanish Soc Hematology. Cancer Medicine. 2020 Apr;9(7):2317-2329. doi: 10.1002/cam4.2814. PMID: 32022463

Acute myeloid leukemia with NPM1 mutation and favorable European LeukemiaNet category: outcome after preemptive intervention based on measurable residual disease. Bataller A, Onate G, Diaz-Beya M, Guijarro F, Garrido A, Vives S, Tormo Diaz M, Arnan M, Salamero O, Sampol A, Coll R, Vall-Llovera F, Oliver-Caldes A, Lopez-Guerra M, Pratcorona M, Zamora L, Villamón Ribate E, Rou G, Blanco A, Nomdedeu J, Colomer D, Brunet S, Sierra J, Esteve J, Grp Cooperativo Estudio Tratamient. British Journal of Haematology. 2020 Oct;191(1):52-61. doi: 10.1111/bjh.16857. PMID: 32510599

An investigation of the utility of plasma Cytomegalovirus (CMV) microRNA detection to predict CMV DNAemia in allogeneic hematopoietic stem cell transplant recipients. Talaya Peñalver A, Gimenez Quiles E, Pascual M, Gago B, Piñana Sanchez J, Hernandez Boluda J, Vazquez L, Garcia M, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Medical Microbiology And Immunology. 2020 Feb;209(1):15-21. doi: 10.1007/s00430-019-00632-7. PMID: 31478067

Application of a digital PCR method for WT1 to myeloid neoplasms in CR and deep ELN WT1 molecular response (< 10 copies). Bussaglia E, Pratcorona M, Carricondo M, Sansegundo L, Rubio M, Monter A, Brell A, Badell I, Esteve J, Arnan M, Talarn C, Tormo Diaz M, Garcia A, Vall-Llovera F, Ortin X, Pedro C, Bargay J, Brunet S, Sierra J, Nomdedeu J. Annals of Hematology. 2020 Apr;99(4):765-772. doi: 10.1007/s00277-020-03910-0. PMID: 32062741

Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell transplantation. Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Hernandez Boluda J, Gimenez Quiles E, Gomez M, Balaguer-Rosello A, Gonzalez-Barbera E, Guerreiro M, Aguilar C, Navarro Ortega D, Solano Vercet C, Sanz J, Luis Pinana J. Transplant Infectious Disease. 2020 Aug;22(4):e13301. doi: 10.1111/tid.13301. PMID: 32363665

Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols. Sobas M, Rodriguez-Veiga R, Vellenga E, Paluszewska M, De la Serna J, Garcia-Alvarez F, Gil C, Brunet S, Bergua J, Gonzalez-Campos J, Ribera J, Tormo Diaz M, Gonzalez M, Fernandez I, Benavente C, Gonzalez-Sanmiguel J, Esteve J, Perez-Encinas M, Salamero O, Manso F, Lowenberg B, Sanzs M, Montesinos P, PETHEMA H. European Journal of Haematology. 2020 Mar;104(3):162-169. doi: 10.1111/ejh.13346. PMID: 31724208

Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens. Luis Pinana J, Albert Vicent E, Dolores Gomez M, Perez Martinez A, Hernandez Boluda J, Montoro J, Salavert M, Maria Gonzalez E, Tormo Diaz M, Gimenez Quiles E, Villalba M, Balaguer-Rosello A, Hernani Morales R, Bueno Ferrando F, Borras Salvador R, Sanz J, Solano Vercet C, Navarro Ortega D. The Journal of infection. 2020 May;80(5):578-606. doi: 10.1016/j.jinf.2020.01.001. PMID: 31926954

Clinico-biological characteristics of patients with myelofibrosis: an analysis of 1,000 cases from the Spanish Registry of Myelofibrosis. Pastor Galan I, Hernandez Boluda J, Correa J, Alvarez-Larran A, Ferrer-Marin F, Raya J, Ayala R, Velez P, Perez-Encinas M, Estrada N, Garcia-Gutierrez V, Fox M, Payer A, Kerguelen A, Cuevas B, Duran M, Ramirez M, Gomez-Casares M, Mata-Vazquez M, Mora E, Martinez-Valverde C, Arbelo E, Angona A, Magro E, Antelo M, Somolinos N, Cervantes F, Grupo Espanol De Enfermedades Mieloproliferativas Filadelf. Medicina Clinica. 2020 Aug 28;155(4):152-158. doi: 10.1016/j.medcli.2019.11.007. PMID: 31980217

Corrigendum to «Performance of prognostic scoring systems in elderly patients with acute myeloid leukaemia on intensive chemotherapy: A PETHEMA registry study» [Leuk. Res. 92 (March) (2020) 106352. Rodríguez-Medina C, Martínez-Cuadrón D, Cano I, Gil C, Tormo Diaz M, Del Pilar Martínez-Sánchez M, Del Castillo T, Serrano-López J, Benavente C, Herrera-Puente P, García-Boyero R, Lavilla-Rubira E, Luz Amigo M, Sayas-Lloris M, Bergua-Burgues J, Pérez-Simón J, Rodríguez G, Espadana A, Vidriales-Vicente B, Fernández R, López-Lorenzo J, López M, García-Fortes M, Gómez J, Colorado-Araujo M, Sossa-Melo C, Aguilar E, Montesinos P. Leukemia Research. 2020 Sep;96:106388. doi: 10.1016/j.leukres.2020.106388. PMID: 32680618

Current Treatment Options for Chronic Myeloid Leukemia Patients Failing Second-Generation Tyrosine Kinase Inhibitors. Garcia-Gutierrez V, Hernandez Boluda J. Journal of Clinical Medicine. 2020 Jul 15;9(7):2251. doi: 10.3390/jcm9072251. PMID: 32679880

Cytomegalovirus DNA load monitoring in stool specimens for anticipating the occurrence of intestinal acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: Is it of any value?. Bueno Ferrando F, Albert Vicent E, Gimenez Quiles E, Pinana J, Perez Martinez A, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Aug 9;e13440. doi: 10.1111/tid.13440. PMID: 32772456

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2020 Nov 11. doi: 10.1002/jmv.26661. PMID: 33174620

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Evolving treatment patterns and outcomes in older patients (?60 years) with AML: changing everything to change nothing?. Martinez-Cuadron D, Serrano J, Gil C, Tormo M, Martinez-Sanchez P, Perez-Simon J, Garcia-Boyero R, Rodriguez-Medina C, Lopez-Pavia M, Benavente C, Bergua J, Lavilla-Rubira E, Amigo M, Herrera P, Alonso-Dominguez J, Bernal T, Colorado M, Sayas M, Algarra L, Vidriales M, Rodriguez-Macias G, Vives S, Perez-Encinas M, Lopez A, Noriega V, Garcia-Fortes M, Ramos F, Rodriguez-Gutierrez J, Costilla-Barriga L, Labrador J, Boluda B, Rodriguez-Veiga R, Martinez-Lopez J, Sanz M, Montesinos P. Leukemia. 2020 Oct 19. doi: 10.1038/s41375-020-01058-4. PMID: 33077867

Feasibility of thiotepa addition to the fludarabine-busulfan conditioning with tacrolimus/sirolimus as graft vs host disease prophylaxis. Fox M, Garcia-Cadenas I, Perez Martinez A, Villacampa G, Pinana J, Orti G, Montoro J, Roldan E, Bosch Vilaseca A, Martino R, Salamero O, Saavedra S, Hernandez Boluda J, Esquirol A, Sierra J, Sanz J, Solano Vercet C, Bosch F, Barba P, Valcarcel D. Leukemia & Lymphoma. 2020 Aug;61(8):1823-1832. doi: 10.1080/10428194.2020.1788015. PMID: 32654570

Features of Cytomegalovirus DNAemia Blips in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Implications for Optimization of Preemptive Antiviral Therapy Strategies. Huntley Pascual D, Talaya Peñalver A, Gimenez Quiles E, Perez Martinez A, Hernandez Boluda J, Hernani Morales R, Torres Fink I, Alberola J, Albert Vicent E, Piñana Sanchez J, Solano Vercet C, Navarro Ortega D. Biology of Blood and Marrow Transplantation. 2020 May;26(5):972-977. doi: 10.1016/j.bbmt.2020.01.015. PMID: 32007638

Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium. Sanchez-Maldonado J, Campa D, Springer J, Badiola J, Niazi Y, Moniz-Diez A, Hernandez-Mohedo F, Gonzalez-Sierra P, Ter Horst R, Macauda A, Brezina S, Cunha C, Lackner M, Lopez-Nevot M, Fianchi L, Pagano L, Lopez-Fernandez E, Potenza L, Luppi M, Moratalla L, Rodriguez-Sevilla J, Fonseca J, Tormo Diaz M, Solano Vercet C, Clavero E, Romero A, Li Y, Lass-Florl C, Einsele H, Vazquez L, Loeffler J, Hemminki K, Carvalho A, Netea M, Gsur A, Dumontet C, Canzian F, Forsti A, Jurado M, Sainz J. Blood Cancer Journal. 2020 Jul 16;10(7):75. doi: 10.1038/s41408-020-00341-y. PMID: 32678078

Impact of clinical features, cytogenetics, genetic mutations, and methylation dynamics of CDKN2B and DLC-1 promoters on treatment response to azacitidine. Martin Gonzalez I, Navarro Cubells B, Serrano Alcalá A, Villamón Ribate E, Calabuig Muñoz M, Solano Vercet C, Chaves Martínez F, Yague N, Orts M, Amat Martínez P, Fuentes Trillo A, Seda García E, García García F, Hernandez Boluda J, Tormo Diaz M. Annals of Hematology. 2020 Mar;99(3):527-537. doi: 10.1007/s00277-020-03932-8. PMID: 31989250

Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with post-transplantation cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Jesus Pascual M, Hernandez Boluda J, Gago B, Vazquez Lopez L, Luis Pinana J, Garcia M, Perez Martinez A, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Feb;22(1):e13206. doi: 10.1111/tid.13206. PMID: 31677215

Kinetics of Torque Teno virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation. Bueno Ferrando F, Albert Vicent E, Pinana J, Perez Martinez A, Ubeda C, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Gimenez Quiles E, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant infectious disease. 2020 Nov 11;e13507. doi: 10.1111/tid.13507. PMID: 33176050

Management of hyperleukocytosis and impact of leukapheresis among patients with acute myeloid leukemia (AML) on short- and long-term clinical outcomes: a large, retrospective, multicenter, international study. Stahl M, Shallis R, Wei W, Montesinos P, Lengline E, Neukirchen J, Bhatt V, Sekeres M, Fathi A, Konig H, Luger S, Khan I, Roboz G, Cluzeau T, Martinez-Cuadron D, Raffoux E, Germing U, Umakanthan J, Mukherjee S, Brunner A, Miller A, McMahon C, Ritchie E, Rodriguez-Veiga R, Itzykson R, Boluda B, Rabian F, Tormo Diaz M, Acuna-Cruz E, Rabinovich E, Yoo B, Cano I, Podoltsev N, Bewersdorf J, Gore S, Zeidan A. Leukemia. 2020 Dec;34(12):3149-3160. doi: 10.1038/s41375-020-0783-3. PMID: 32132655

miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk. Ferrer-Marin F, Arroyo A, Bellosillo B, Cuenca E, Zamora L, Hernandez-Rivas J, Hernandez Boluda J, Fernandez-Rodriguez C, Luno E, Garcia Hernandez C, Kerguelen A, Fiallo-Suarez D, Gomez-Casares M, Ayala R, Velez P, Boque C, Garcia-Gutierrez V, Arrizabalaga B, Estrada N, Cifuentes R, Arcas I, de los Reyes-Garcia A, Besses C, Vicente V, Alvarez-Larran A, Teruel-Montoya R, Gonzalez-Conejero R, Martinez C, GEMFIN Grp. Leukemia. 2020 Oct;34(10):2648-2659. doi: 10.1038/s41375-020-0767-3. PMID: 32107471

Natural history of polycythemia vera and essential thrombocythemia presenting with splanchnic vein thrombosis. Alvarez-Larran A, Pereira A, Magaz M, Hernandez Boluda J, Garrote M, Cuevas B, Ferrer-Marin F, Teresa Gomez-Casares M, Garcia-Gutierrez V, Isabel Mata-Vazquez M, Turon F, Hernandez-Gea V, Arellano-Rodrigo E, Cervantes F, Carlos Garcia-Pagan J, GEMFIN Grp, REHEVASC Grp. Annals of Hematology. 2020 Apr;99(4):791-798. doi: 10.1007/s00277-020-03965-z. PMID: 32086587

Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML Project. Sargas C, Ayala R, Chillon M, Larrayoz M, Carrillo-Cruz E, Bilbao C, Yebenes-Ramirez M, Llop M, Rapado I, Garcia-Sanz R, Vazquez I, Soria E, Florido-Ortega Y, Janusz K, Botella C, Serrano J, Martinez-Cuadron D, Bergua J, Amigo M, Martinez-Sanchez P, Tormo Diaz M, Bernal T, Herrera-Puente P, Garcia R, Algarra L, Sayas M, Costilla-Barriga L, Perez-Santolalla E, Marchante I, Lavilla-Rubira E, Noriega V, Alonso-Dominguez J, Sanz M, Sanchez-Garcia J, Gomez-Casares M, Perez-Simon J, Calasanz M, Gonzalez-Diaz M, Martinez-Lopez J, Barragan E, Montesinos P. Haematologica. 2020 Nov 12. doi: 10.3324/haematol.2020.263806. PMID: 33179471

Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT. McLornan D, Malpassuti V, Lippinkhof-Kozijn A, Potter V, Beelen D, Bunjes D, Sengeloev H, Radujkovic A, Passweg J, Chalandon Y, Kroeger N, Wulf G, Johansson J, Ciceri F, Bornhaeuser M, Holler E, Guffroy B, Martin S, Neubauer A, Gramatski M, Robin M, Iacobelli S, Hayden P, Hernandez Boluda J, Czerw T, Yakoub-Agha I. British Journal of Haematology. 2020 Aug;190(3):437-441. doi: 10.1111/bjh.16537. PMID: 32108327

Outcome of older (>= 70 years) APL patients frontline treated with or without arsenic trioxide-an International Collaborative Study. Kayser S, Rahme R, Martinez-Cuadron D, Ghiaur G, Thomas X, Sobas M, Guerci-Bresler A, Garrido A, Pigneux A, Gil C, Raffoux E, Tormo Diaz M, Vey N, de la Serna J, Salamero O, Lengfelder E, Levis M, Fenaux P, Sanz M, Platzbecker U, Schlenk R, Ades L, Montesinos P. Leukemia. 2020 Sep;34(9):2333-2341. doi: 10.1038/s41375-020-0758-4.PMID: 32076120

Patterns of care and clinical outcomes of patients with newly diagnosed acute myeloid leukemia presenting with hyperleukocytosis who do not receive intensive chemotherapy. Shallis R, Stahl M, Wei W, Montesinos P, Lengline E, Neukirchen J, Bhatt V, Sekeres M, Fathi A, Konig H, Luger S, Khan I, Roboz G, Cluzeau T, Martinez-Cuadron D, Raffoux E, Germing U, Umakanthan J, Mukhereje S, Brunner A, Miller A, McMahon C, Ritchie E, Rodriguez-Veiga R, Itzykson R, Boluda B, Rabian F, Tormo Diaz M, Cruz E, Rabinovich E, Yoo B, Cano I, Podoltsev N, Bewersdorf J, Gore S, Zeidan A. Leukemia & Lymphoma. 2020 May;61(5):1220-1225. doi: 10.1080/10428194.2020.1728753. PMID: 32100599

Performance of prognostic scoring systems in elderly patients with acute myeloid leukaemia on intensive chemotherapy: A PETHEMA registry study. Rodriguez-Medina C, Martinez-Cuadron D, Cano I, Gil C, Tormo Diaz M, Del Pilar Martinez-Sanchez M, Del Castillo T, Serrano-Lopez J, Benavente C, Herrera-Puente P, Garcia-Boyero R, Lavilla-Rubira E, Amigo M, Sayas-Lloris M, Bergua-Burgues J, Perez-Simon J, Rodriguez G, Espadana A, Vidriales-Vicente B, Fernandez R, Lopez-Lorenzo J, Lopez M, Garcia-Fortes M, Labrador Gomez J, Colorado-Araujo M, Sossa-Melo C, Aguilar E, Montesinos Fernandez P. Leukemia Research. 2020 Mar 23;92:106352. doi: 10.1016/j.leukres.2020.106352. PMID: 32240863

Peripheral blood regulatory T cells and occurrence of Cytomegalovirus DNAemia after unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Vázquez L, Amat Martínez P, Remigia Pellicer M, Hernández M, Hernandez Boluda J, Gago B, Piñana Sanchez J, García M, Perez Martinez A, Alberola J, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1493-1496. doi: 10.1038/s41409-020-0950-1. PMID: 32447351

Predicting Survival after Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis: Performance of the Myelofibrosis Transplant Scoring System (MTSS) and Development of a New Prognostic Model: Prognostication in myelofibrosis. Hernandez Boluda J, Pereira A, Alvarez-Larran A, Martin A, Benzaquen Vallejos A, Aguirre L, Mora E, Gonzalez P, Mora J, Dorado N, Sampol A, Garcia-Gutierrez V, Lopez-Godino O, Fox M, Reguera J, Perez-Encinas M, Pascual M, Xicoy B, Parody R, Gonzalez-Pinedo L, Espanol I, Avendano A, Correa J, Vallejo C, Jurado M, Garcia-Cadenas I, Osorio S, Duran M, Sanchez-Guijo F, Cervantes F, Pinana J. Biology of Blood and Marrow Transplantation. 2020 Dec;26(12):2237-2244. doi: 10.1016/j.bbmt.2020.07.022. PMID: 32717433

Prospective Randomized Study Comparing Myeloablative Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Stem Cell Transplantation for Adults with Hematologic Malignancies. Sanz J, Montoro J, Solano Vercet C, Valcarcel D, Sampol A, Ferra C, Parody R, Lorenzo I, Montesinos P, Orti G, Hernandez Boluda J, Balaguer-Rosello A, Guerreiro M, Carretero C, Sanz G, Sanz M, Pinana J. Biology of Blood and Marrow. 2020 Feb;26(2):358-366. doi: 10.1016/j.bbmt.2019.10.014. PMID: 31655119

Reconstitution of cytomegalovirus-specific T-cell immunity following unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Remigia Pellicer M, Amat Martínez P, Vazquez Lopez L, Hernandez M, Hernandez Boluda J, Gago B, Piñana Sanchez J, Garcia M, Perez Martinez A, Mateo Jimenez E, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1347-1356. doi: 10.1038/s41409-020-0865-x. PMID: 32205853

Scute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2). study of 61 patients treated with intensive protocols.. Sitges M, Boluda B, Garrido A, Morgades M, Granada I, Barragan E, Arnan M, Serrano J, Tormo Diaz M, Miguel Bergua J, Colorado M, Salamero O, Esteve J, Benavente C, Perez-Encinas M, Coll R, Marti-Tutusaus J, Brunet S, Sierra J, Angel Sanz M, Montesinos P, Ribera J, Vives S, PETHEMA C. European Journal of Haematology. 2020 Aug;105(2):138-147. doi: 10.1111/ejh.13417. PMID: 32243655

Severe thrombocytopenia in myelofibrosis is more prevalent than previously reported Masarova L, Mesa R, Hernandez Boluda J, Taylor J. Leukemia Research. 2020 Apr;91:106338. doi: 10.1016/j.leukres.2020.106338. PMID: 32200188

The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey. Pinana J, Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Gimenez Quiles E, Gomez M, Guerreiro M, Gonzalez-Barbera E, Carretero C, Salavert M, Balaguer-Rosello A, Sanz G, Hernandez Boluda J, Solano Vercet C, Sanz J, Navarro Ortega D. Bone Marrow Transplantation. 2020 Feb;55(2):431-440. doi: 10.1038/s41409-019-0698-7. PMID: 31551521

Treatment of Frail Older Adults and Elderly Patients With Philadelphia Chromosome-negative Acute Lymphoblastic Leukemia: Results of a Prospective Trial With Minimal Chemotherapy. Ribera J, Garcia O, Chapchap E, Gil C, Gonzalez-Campos J, Barba P, Amigo M, Moreno M, Lavilla E, Alonso N, Bergua J, Tormo Diaz M, Ribera J, Sierra M, Martinez-Carballeira D, Mercadal S, Hernandez-Rivas J, Vall-Llovera F, Genesca E, Cladera A, Novo A, Abella E, Garcia-Cadenas I, Monteserin C, Bermudez A, Piernas S, Montesinos P, Lopez J, Garcia-Guinon A, Serrano A, Martinez M, Olivares M, Lopez A, Serrano J, PETHEMA Group S. Clinical Lymphoma, Myeloma & Leukemia. 2020 Aug;20(8):e513-e522. doi: 10.1016/j.clml.2020.03.011. PMID: 32336676

UGT1A1 genotype influences clinical outcome in patients with intermediate-risk acute myeloid leukemia treated with cytarabine-based chemotherapy. Diaz-Santa J, Rodriguez-Romanos R, Osca G, Pratcorona M, Garrido A, Coll R, Moret C, Escoda L, TORMO DIAZ M, Heras I, Arnan M, Vives S, Salamero O, Lloveras N, Bargay J, Sampol A, Cruz D, Garcia A, Quinones T, Esteve J, Sierra J, Gallardo D, on the behalf of CETLAM Group. Leukemia. 2020 Nov;34(11):2925-2933. doi: 10.1038/s41375-020-0784-2. PMID: 32152464

Uniform graft-versus-host disease prophylaxis with posttransplant cyclophosphamide, sirolimus, and mycophenolate mofetil following hematopoietic stem cell transplantation from haploidentical, matched sibling and unrelated donors. Montoro J, Pinana J, Hernandez Boluda J, Hernani Morales R, Lorenzo I, Perez Martinez A, Guerreiro M, Balaguer-Rosello A, Sanz G, Carretero C, Albert Vicent E, Navarro Ortega D, Sanz M, Solano Vercet C, Sanz J. Bone Marrow Transplantation. 2020 Nov;55(11):2147-2159. doi: 10.1038/s41409-020-0921-6. PMID: 32371901

Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia. Genesca E, Morgades M, Montesinos P, Barba P, Gil C, Guardia R, Moreno M, Martinez-Carballeira D, Garcia-Cadenas I, Vives S, Ribera J, Gonzalez-Campos J, Gonzalez-Gil C, Zamora L, Ramirez J, Diaz-Beya M, Mercadal S, Artola M, Cladera A, Tormo Diaz M, Bermudez A, Vall-Llovera F, Martinez P, Amigo M, Monsalvo S, Novo A, Cervera M, Garcia-Guinon A, Junca J, Ciudad J, Orfao A, Ribera J. Haematologica. 2020 Jun;105(6):e294-e297. doi: 10.3324/haematol.2019.225078. PMID: 31537688

A precision medicine test predicts clinical response after idarubicin and cytarabine induction therapy in AML patients. Martínez-Cuadrón D, Gil C, Serrano J, Rodríguez G, Pérez-Oteyza J, García-Boyero R, Jiménez-Bravo S, Vives S, Vidriales MB, Lavilla E, Pérez-Simón JA, Tormo M, Colorado M, Bergua J, López JA, Herrera P, Hernández-Campo P, Gorrochategui J, Primo D, Rojas JL, Villoria J, Moscardó F, Troconiz I, Linares Gómez M, Martínez-López J, Ballesteros J, Sanz M, Montesinos P; Spanish PETHEMA group. Leukemia Research. 2019 Jan;76:1-10. doi: 10.1016/j.leukres.2018.11.006. PMID: 30468991

An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens. Sobas M, Montesinos P, Boluda B, Bernal T, Vellenga E, Nomdedeu J, González-Campos J, Chillón M, Holowiecka A, Esteve J, Bergua J, González-Sanmiguel JD, Gil-Cortes C, Tormo M, Salamero O, Manso F, Fernández I, de la Serna J, Moreno MJ, Pérez-Encinas M, Krsnik I, Ribera JM, Escoda L, Lowenberg B, Sanz MA; PETHEMA, HOVON, PALG, and GATLA cooperative groups. Leukemia & Lymphoma. 2019 Apr;60(4):1030-1035. doi: 10.1080/10428194.2018.1516875. PMID: 30322324

Ceftolozane Pharmacokinetics in a Septic Critically Ill Patient under Different Extracorporeal Replacement Therapies. Carbonell N, Aguilar G, Ferriols R, Huerta R, Ferreres J, Calabuig M, Juan M, Ezquer C, Colomina J, Blasco ML. Antimicrobial agents and chemotherapy. 2019 Dec 20;64(1):e01782-19. doi: 10.1128/AAC.01782-19. PMID: 31658972

Clinical effectiveness of influenza vaccination after allogeneic hematopoietic stem cell transplantation: A cross-sectional prospective observational study. Piñana JL, Pérez A, Montoro J, Giménez E, Gómez MD, Lorenzo I, Madrid S, González EM, Vinuesa V, Hernández-Boluda JC, Salavert M, Sanz G, Solano C, Sanz J, Navarro D. Clinical Infectious Diseases. 2019 May 17;68(11):1894-1903. doi: 10.1093/cid/ciy792. PMID: 30239624

Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy. Labrador J, Luño E, Vellenga E, Brunet S, González-Campos J, Chillón MC, Holowiecka A, Esteve J, Bergua J, González-Sanmiguel JD, Gil C, Tormo M, Salamero O, Manso F, Fernández I, de laSerna J, Moreno MJ, Pérez-Encinas M, Krsnik I, Ribera JM, Cervera J, Calasanz MJ, Boluda B, Sobas M, Lowenberg B, Sanz MA, Montesinos P. Leukemia & Lymphoma. 2019 May;60(5):1146-1155. doi: 10.1080/10428194.2018.1522438. PMID: 30526152

Cytomegalovirus (CMV) infection and risk of mortality in allogeneic hematopoietic stem cell transplantation (Allo-SCT): A systematic review, meta-analysis and meta-regression analysis. Giménez E, Torres I, Albert E, Piñana JL, Hernández-Boluda JC, Solano C, Navarro D. American Journal of Transplantation. 2019 Sep;19(9):2479-2494. doi: 10.1111/ajt.15515. PMID: 31247126

Cytomegalovirus DNAemia in patients with de novo acute myeloid leukemia undergoing cytotoxic chemotherapy. Tormo M, Giménez E, Calabuig M, Talaya A, Navarro B, Amat P, Martín I, Albert E, Solano C, Navarro D. Leukemia & Lymphoma. 2019 Dec;60(12):3081-3083. doi: 10.1080/10428194.2019.1613541. PMID: 31111760

Cytomegalovirus-specific CD8+ T cell levels at viral DNAemia onset fail to predict the eventual need for preemptive antiviral therapy in allogeneic hematopoietic stem cell transplant recipients. Giménez E, Solano C, Piñana JL, Poch M, Mateo E, Albert E, Hernández-Boluda JC, Amat P, Remigia MJ, Pérez A, Navarro D. Journal of Infectious Diseases. 2019 Apr 16;219(9):1510-1512. doi: 10.1093/infdis/jiy746. PMID: 30597050

Differences in ex-vivo Chemosensitivity to Anthracyclines in First Line Acute Myeloid Leukemia. Megías-Vericat JE, Martínez-Cuadrón D, López JM, Bergua JM, Tormo M, Serrano J, González A, de Oteyza JP, Vives S, Vidriales B, Herrera P, Vera JA, Martínez AL, de la Fuente A, Amador ML, Hernández-Rivas JÁ, Fernández MÁ, Cerveró CJ, Morillo D, Campo PH, Gorrochategui J, Primo D, Rojas JL, Guenova M, Ballesteros J, Sanz M, Montesinos P. Mediterranean Journal of Hematology and Infectious Diseases. 2019 Mar 1;11(1):e2019016. doi: 10.4084/MJHID.2019.016. PMID: 30858954

Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. Guglieri-Lopez B, Perez-Pitarch A, Garcia-Cadenas I, Gimenez E, Barba P, Rabella N, Hernandez-Boluda JC, Fox L, Valcarcel D, Esquirol A, Ferriols-Lisart R, Sierra J, Solano C, Navarro D, Martino R, Piñana JL. Biology of Blood and Marrow Transplantation. 2019 May;25(5):1022-1030. doi: 10.1016/j.bbmt.2019.01.012. PMID: 30639821

Factors influencing cytomegalovirus DNA load measurements in whole blood and plasma specimens from allogeneic hematopoietic stem cell transplant recipients. Vinuesa V, Giménez E, Solano C, Albert E, Torres I, Pérez A, Hernández-Boluda JC, Piñana JL, Navarro D. Diagnostic Microbiology and Infectious Disease. 2019 May;94(1):22-27. doi: 10.1016/j.diagmicrobio.2018.11.012. PMID: 30579656

Genomic characterization in triple-negative primary myelofibrosis and other myeloid neoplasms with bone marrow fibrosis. Alvarez-Larrán A, López-Guerra M, Rozman M, Correa JG, Hernández-Boluda JC, Tormo M, Martínez D, Martín I, Colomer D, Esteve J, Cervantes F. Annals of Hematology. 2019 Oct;98(10):2319-2328. doi: 10.1007/s00277-019-03766-z. PMID: 31396671

Incidence and outcome after first molecular versus overt recurrence in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia included in the ALL Ph08 trial from the Spanish PETHEMA Group. Ribera JM, García O, Moreno MJ, Barba P, García-Cadenas I, Mercadal S, Montesinos P, Barrios M, González-Campos J, Martínez-Carballeira D, Gil C, Ribera J, Vives S, Novo A, Cervera M, Serrano J, Lavilla E, Abella E, Tormo M, Amigo ML, Artola MT, Genescà E, Bravo P, García-Belmonte D, García-Guiñón A, Hernández-Rivas JM, Feliu E; PETHEMA Group of the Spanish Society of Hematology. Cancer. 2019 Aug 15;125(16):2810-2817. doi: 10.1002/cncr.32156. PMID: 31012967

Incidence, risk factors, and outcome of pulmonary invasive fungal disease after respiratory virus infection in allogeneic hematopoietic stem cell transplantation recipients. Piñana JL, Gómez MD, Montoro J, Lorenzo I, Pérez A, Giménez E, González-Barberá EM, Carretero C, Guerreiro M, Salavert M, Sanz G, Hernández-Boluda JC, Borrás R, Sanz J, Solano C, Navarro D. Transplant infectious disease. 2019 Oct;21(5):e13158. doi: 10.1111/tid.13158. PMID: 31402532

Increased survival due to lower toxicity for high-risk T-cell acute lymphoblastic leukemia patients in two consecutive pediatric-inspired PETHEMA trials. Barba P, Morgades M, Montesinos P, Gil C, Fox ML, Ciudad J, Moreno MJ, González-Campos J, Genescà E, Martínez-Carballeira D, Martino R, Vives S, Guardia R, Mercadal S, Artola MT, Cladera A, Tormo M, Esteve J, Bergua J, Vall-Llovera F, Ribera J, Martínez-Sanchez P, Amigo ML, Bermúdez A, Calbacho M, Hernández-Rivas JM, Feliu E, Orfao A, Ribera JM. European Journal of Haematology. 2019 Jan;102(1):79-86. doi: 10.1111/ejh.13178. PMID: 30267597

Kinetics of Alphatorquevirus plasma DNAemia at late times after allogeneic hematopoietic stem cell transplantation-. Albert E, Solano C, Giménez E, Focosi D, Pérez A, Macera L, Piñana JL, Mateo EM, Boluda JCH, Maggi F, Navarro D. Medical Microbiology and Immunology. 2019 Apr;208(2):253-258. doi: 10.1007/s00430-019-00586-w. PMID: 30852649

Kinetics of inflammatory biomarkers in plasma predict the occurrence and features of cytomegalovirus DNAemia episodes in allogeneic hematopoietic stem cell transplant recipients. Talaya A, Giménez E, Vinuesa V, Pérez A, Amat P, Piñana JL, Albert E, Hernández-Boluda JC, Solano C, Navarro D. Medical Microbiology and Immunology. 2019 Aug;208(3-4):405-414. doi: 10.1007/s00430-019-00594-w. PMID: 30911925

Molecular profiling refines minimal residual disease-based prognostic assessment in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia. Ribera J, Zamora L, Morgades M, Vives S, Granada I, Montesinos P, Gomez-Segui I, Mercadal S, Guardia R, Nomdedeu J, Pratcorona M, Tormo Diaz M, Martinez-Lopez J, Hernandez-Rivas J, Ciudad J, Orfao A, Gonzalez-Campos J, Barba P, Escoda L, Esteve J, Genesca E, Sole F, Feliu E, Ribera J, Spanish PETHEMA Grp, Spanish Soc Hematology. Genes Chromosomes & Cancer. 2019 Nov;58(11):815-819. doi: 10.1002/gcc.22788. PMID: 31340073

Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia. Giménez N, Martínez-Trillos A, Montraveta A, Lopez-Guerra M, Rosich L, Nadeu F, Valero JG, Aymerich M, Magnano L, Rozman M, Matutes E, Delgado J, Baumann T, Gine E, González M, Alcoceba M, Terol MJ, Navarro B, Colado E, Payer AR, Puente XS, López-Otín C, Lopez-Guillermo A, Campo E, Colomer D, Villamor N. Haematologica. 2019 Mar;104(3):576-586. doi: 10.3324/haematol.2018.196931. PMID: 30262568

Myeloablative and Reduced-Intensity Conditioned Allogeneic Hematopoietic Stem Cell Transplantation in Myelofibrosis: A Retrospective Study by the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation. McLornan D, Szydlo R, Koster L, Chalandon Y, Robin M, Wolschke C, Beelen D, Socié G, Bornhäuser M, Angelucci E, Niederwieser D, Gerbitz A, Finke J, Vitek A, Itälä-Remes M, Radujkovic A, Kanz L, Potter V, Chevallier P, Stelljes M, Petersen E, Robinson S, Poiré X, Klyuchnikov E, Hernández-Boluda JC, Czerw T, Hayden P, Kröger N, Yakoub-Agha I. Biology of Blood and Marrow Transplantation. 2019 Nov;25(11):2167-2171. doi: 10.1016/j.bbmt.2019.06.034. PMID: 31284069

Pharmacokinetic/pharmacodynamic analysis of voriconazole against Candida spp. and Aspergillus spp. in allogeneic stem cell transplant recipients. Perez-Pitarch A, Guglieri-Lopez B, Ferriols-Lisart R, Pérez A, Ezquer-Garín C, Hernández-Boluda JC, Piñana JL, Navarro D, Solano C, Alós-Almiñana M. Therapeutic Drug Monitoring. 2019 Dec;41(6):740-747. doi: 10.1097/FTD.0000000000000657. PMID: 31136417

Pre-engraftment cytomegalovirus DNAemia in allogeneic hematopoietic stem cell transplant recipients: incidence, risk factors, and clinical outcomes. Solano C, Giménez E, Albert E, Mateo EM, Gómez M, Goterris R, Pérez A, Amat P, Hernández-Boluda JC, Poch M, Piñana JL, Navarro D. Bone Marrow Transplantation. 2019 Jan;54(1):90-98. doi: 10.1038/s41409-018-0251-0. PMID: 29899574

Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia. Piñana JL, Giménez E, Gómez MD, Pérez A, González EM, Vinuesa V, Hernández-Boluda JC, Montoro J, Salavert M, Tormo M, Amat P, Moles P, Carretero C, Balaguer-Roselló A, Sanz J, Sanz G, Solano C, Navarro D. Journal of Infection. 2019 May;78(5):393-401. doi: 10.1016/j.jinf.2019.02.009. PMID: 30797790

Safety and efficacy of bosutinib in fourth-line therapy of chronic myeloid leukemia patients. García-Gutiérrez V, Milojkovic D, Hernandez-Boluda JC, Claudiani S, Martin Mateos ML, Casado-Montero LF, González G, Jimenez-Velasco A, Boque C, Martinez-Trillos A, Vázquez IM, Payer ÁR, Senín A, Amustio Díez E, García AB, Carrascosa GB, Ortí G, Ruiz BC, Fernández MÁ, Del Carmen García Garay M, Giraldo P, Guinea JM, De Las Heras Rodríguez N, Hernán N, Pérez AI, Piris-Villaespesa M, Lorenzo JLL, Martí-Tutusaus JMM, Vallansot RO, Ortega Rivas F, Puerta JM, Ramirez MJ, Romero E, Romo A, Rosell A, Saavedra SS, Sebrango A, Tallon J, Valencia S, Portero A, Steegmann JL; Grupo Español de Leucemia Mieloide Crónica (GELMC). Annals of Hematology. 2019 Feb;98(2):321-330. doi: 10.1007/s00277-018-3507-2. PMID: 30446802

Spontaneously-resolving episodes of cytomegalovirus DNAemia in allogeneic hematopoietic stem cell transplant recipients: Virological features and clinical outcomes. Talaya A, Giménez E, Piñana JL, Albert E, Hernández-Boluda JC, Pérez A, Torres I, Solano C, Navarro D. Journal of Medical Virology. 2019 Jun;91(6):1128-1135. doi: 10.1002/jmv.25426. PMID: 30735250

Synergistic Antioncogenic Activity of Azacitidine and Curcumin in Myeloid Leukemia Cell Lines and Patient Samples. Martín I, Navarro B, Solano C, Calabuig M, Hernández-Boluda JC, Amat P, Remigia MJ, García F, Villamón E, Tormo M. Anticancer Research. 2019 Sep;39(9):4757-4766. doi: 10.21873/anticanres.13659. PMID: 31519576

The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients. Ribera J, Granada I, Morgades M, Vives S, Genescà E, González C, Nomdedeu J, Escoda L, Montesinos P, Mercadal S, Coll R, González-Campos J, Abella E, Barba P, Bermúdez A, Gil C, Tormo M, Pedreño M, Martínez-Carballeira D, Hernández-Rivas JM, Orfao A, Martínez-López J, Esteve J, Bravo P, Garcia-Guiñon A, Debén G, Moraleda JM, Queizán JA, Ortín X, Moreno MJ, Feliu E, Solé F, Ribera JM; PETHEMA Group, Spanish Society of Haematology. British Journal of Haematology. 2019 Jul;186(2):263-268. doi: 10.1111/bjh.15887. PMID: 30916384

Tyrosine Kinase Inhibitors Available for Chronic Myeloid Leukemia: Efficacy and Safety. García-Gutiérrez V, Hernández-Boluda JC. Frontiers in Oncology. 2019 Jul 3;9:603. doi: 10.3389/fonc.2019.00603. PMID: 31334123

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Título: Caracterización molecular de la anemia refractaria con sideroblastos en anillo mediante un panel de secuenciación de segunda generación
Doctorando: Martín Castillo, Iván
Director: Sanz Alonso, Miguel Ángel; Such Taboada, Esperanza; Cervera Zamora, Jose Vicente
Fecha: 06/02/2020
Universidad: Universitat de València

Título: Rol del complejo runx1-cbf-?/hipk2/p300/p53 en la evolución leucémica de las neoplasias mieloproliferativas crónicas
Doctorando: Lozano Asencio, Carlos Alberto
Director: Hernández Boluda, Juan Carlos; Climent Bataller, Joan
Fecha: 14/02/2020
Universidad: Universitat de València

Título: Análisis de la relación coste-efectividad del tratamiento con azacitidina en pacientes con síndrome mielodisplásico en el hospital clínico universitario de valencia
Doctorando: Torrecilla Junyent, Teresa
Director: Alós Almiñana, Manuel; Tormo Díaz, María del Mar; Cortijo Gimeno, Julio
Fecha: 12/06/2019
Universidad: Universitat de València