Grupo de Investigación en Microbiología Molecular y Patogénesis Microbiana

Área de Oncología

Estudio de los aspectos básicos de las enfermedades infecciosas

Estudio de los microorganismos causantes de patología humana, caracterización, bilogía y fisiopatogenia

La implementación y optimación del uso de nuevas tecnologías diagnósticas en el manejo clínico del paciente infeccioso, en particular en el contexto de una patología onco-hematológica de base

Creación de Unidades multidisciplinares de «diagnostic stewardship» (Programas de optimación del uso de técnicas diagnósticas-PRODIM-) con otros servicios (Oncología/Hematología/UCI/Reanimación, Asistencia Primaria)

Estudio de la inmunobiología del paciente con enfermedades infecciosas, caracterización y estudio de su repercusión clínica en los individuos y la sociedad

Coordinador
Dr. David Navarro Ortega
david.navarro@uv.es/navarrod@uv.es

INVESTIGADORES
R4 Senior

David Navarro Ortega    

R3 Consolidado
R2 Novel / Emergente

Eliseo Alejandro Albert Vicent    
Estela Giménez Quiles    

R1 Predoctoral

Ignacio Torres Fink

STAFF
Colaborador/a

Javier Colomina Rodríguez
Mª Ángeles Clari Pons

Enfermero/a
Técnico/a
Apoyo
Publicaciones
Booster effect after SARS-CoV-2 vaccination in immunocompromised hematology patients with prior COVID-19. Piñana JL, Garcia-Sanz R, Martino R, Garcia-Roa M, Martin-Martin GA, Risco-Gálvez I, Tormo M, Martinez-Barranco P, Marcos-Corrales S, Calabuig M, Conesa V, Teruel A, Ruiz-Pérez S, Solano C, Navarro D, Cedillo Á, Sureda A. Blood Advances. 2022 Jan 8;6(3):848-853. doi: 10.1182/bloodadvances.2021006326. PMID: 34905620

Comparative evaluation of molecular methods for the quantitative measure of torquetenovirus viremia, the new surrogate marker of immune competence. Macera L, Spezia PG, Medici C, Rofi E, Del Re M, Focosi D, Mazzetti P, Navarro D, Antonelli G, Danesi R, Pistello M, Maggi F. Journal of Medical Virology. 2022 Feb;94(2):491-498. doi: 10.1002/jmv.25488. PMID: 31002743

Evolution of SARS-CoV-2 immune responses in nursing home residents following full dose of the Comirnaty COVID-19 vaccine. Gimenez E, Alberola J, Torres I, Albert E, Alcaraz MJ, Botija P, Amat P, Remigia MJ, Beltran MJ, Rodado C, Huntley D, Olea B, Navarro D. Journal of Infection. 2022 Mar;84(3):418-467. doi: 10.1016/j.jinf.2021.10.026. PMID: 34740744

Human genetic polymorphisms and risk of viral infection after solid organ transplantation. Redondo N, Navarro D, Aguado JM, Fernandez-Ruiz M. Transplantation Reviews. 2022 Jan;36(1):100669. doi: 10.1016/j.trre.2021.100669. PMID: 34688126

Methicillin-resistant Staphylococcus epidermidis infectious keratitis: clinical and microbiological profile. Vidal Oliver L, Bayo Calduch P, Forque Rodriguez L, Navarro Ortega D, Duch Samper AM, Colomina Rodriguez J. Revista Espanola de Quimioterapia. 2022 Apr;35(2):171-177. doi: 10.37201/req/128.2021. PMID: 35067009

Monitoring of Torque Teno virus DNAemia in critically ill COVID-19 patients: may it help to predict clinical outcomes?. Forque L, Albert E, Gimenez E, Torres I, Carbonell N, Ferreres J, Blasco M, Navarro D. Journal of Clinical Virology. 2022 Jan 23;148:105082. doi: 10.1016/j.jcv.2022.105082. PMID: 35091226

Multi-body-site colonization screening cultures for predicting multi-drug resistant Gram-negative and Gram-positive bacteremia in hematological patients. Torres I, Huntley D, Tormo M, Calabuig M, Hernandez-Boluda J, Terol M, Carretero C, de Michelena P, Perez A, Pinana J, Colomina J, Solano C, Navarro D. BMC Infectious Diseases. 2022 Feb 21;22(1):172. doi: 10.1186/s12879-022-07154-3. PMID: 35189833

Performance comparison of a flow cytometry immunoassay for intracellular cytokine staining and the QuantiFERON SARS-CoV-2 test for detection and quantification of SARS-CoV-2-Spike-reactive-IFN-gamma-producing T cells after COVID-19 vaccination. Tormo N, Gimenez E, Martinez-Navarro M, Albert E, Navalpotro D, Torres I, Gimeno C, Navarro D. European Journal of Clinical Microbiology & Infectious Diseases. 2022 Feb 15;1-6. doi: 10.1007/s10096-022-04422-7. PMID: 35165804

Real-life performance of a COVID-19 rapid antigen detection test targeting the SARS-CoV-2 nucleoprotein for diagnosis of COVID-19 due to the Omicron variant. de Michelena P, Torres I, Ramos Garcia A, Gozalbes V, Ruiz N, Sanmartin A, Botija P, Poujois S, Huntley D, Albert E, Navarro D. Journal of Infection. 2022 Feb 22;S0163-4453(22)00110-4. doi: 10.1016/j.jinf.2022.02.022. PMID: 35217106

SARS-CoV-2 N-antigenemia in critically ill adult COVID-19 patients: frequency and association with inflammatory and tissue-damage biomarkers. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Medical Virology. 2022 Jan;94(1):222-228. doi: 10.1002/jmv.27300. PMID: 34449894

SARS-CoV-2-reactive antibody detection after SARS-CoV-2 vaccination in hematopoietic stem cell transplant recipients: Prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC). Pinana J, Lopez-Corral L, Martino R, Montoro J, Vazquez L, Perez A, Martin-Martin G, Facal-Malvar A, Ferrer E, Pascual M, Sanz-Linares G, Gago B, Sanchez-Salinas A, Villalon L, Conesa-Garcia V, Olave M, Lopez-Jimenez J, Marcos-Corrales S, Garcia-Blazquez M, Garcia-Gutierrez V, Hernandez-Rivas J, Saus A, Espigado I, Alonso C, Hernani R, Solano C, Ferrer-Lores B, Guerreiro M, Ruiz-Garcia M, Munoz-Bellido J, Navarro D, Cedillo A, Sureda A, Infectious Complications Subcommittee of the Spanish Hematopoietic Stem, Cell Transplantation and Cell Therapy Group (GETH-TC). American Journal of Hematology. 2022 Jan 1;97(1):30-42. doi: 10.1002/ajh.26385. PMID: 34695229

Spanish Society of Hematology and Hemotherapy expert consensus opinion for SARS-CoV-2 vaccination in onco-hematological patients. Pinana J, Vazquez L, Martino R, de la Camara R, Sureda A, Rodriguez-Veiga R, Garrido A, Sierra J, Ribera J, Torrent A, Mateos M, de la Rubia J, Tormo M, Diez-Campelo M, Garcia-Gutierrez V, Alvarez-Larran A, Sancho J, MartinGarcia-Sancho A, Yanez L, Simon J, Barba P, Abrisqueta P, Alvarez-Twose I, Bonanad S, Lecumberri R, Ruiz-Camps I, Navarro D, Hernandez-Rivas J, Cedillo A, Garcia-Sanz R, Bosch F. Leukemia & Lymphoma. 2022 Mar;63(3):538-550. doi: 10.1080/10428194.2021.1992619. PMID: 34668835

Viruses, friends, and foes: the case of Torque Teno Virus and the net state of immunosuppression. Redondo N, Navarro D, Aguado J, Fernandez-Ruiz M. Transplant Infectious Disease. 2022 Apr;24(2):e13778. doi: 10.1111/tid.13778. PMID: 34933413

Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients. Olea B, Albert E, Torres I, Amat P, Remigia M, Gozalbo-Rovira R, Rodriguez-Diaz J, Buesa J, Blasco M, Redon J, Signes-Costa J, Navarro D. Journal of Clinical Virology. 2021 Sep;142:104943. doi: 10.1016/j.jcv.2021.104943. PMID: 34391981

Amplification of human beta-glucoronidase gene for appraising the accuracy of negative SARS-CoV-2 RT-PCR results in upper respiratory tract specimens. Albert Vicent E, Ferrer Lores B, Torres Fink I, Serrano Alcalá A, Alcaráz Soriana M, Buesa Gomez J, Solano Vercet C, Colomina Rodríguez F, Bueno Ferrando F, Huntley Pascual D, Olea Miguel B, Valdivia Piqueres A, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):48-50. doi: 10.1002/jmv.26112. PMID: 32484950

Assessing the potential association between SARS-CoV-2 RNA load in the respiratory tract and COVID-19 mortality. Albert E, Bracho M, Serrano A, Ferrer B, Gonzalez-Candelas F, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):1862-1864. doi: 10.1002/jmv.26644. PMID: 33135804

Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure. Mollar A, Marrachelli V, Nunez E, Monleon D, Bodi V, Sanchis J, Navarro D, Nunez J. Scientific reports. 2021 Mar 17;11(1):6110. doi: 10.1038/s41598-021-85527-5. PMID: 33731747

Caveats in interpreting SARS-CoV-2 IgM positive/IgG negative antibody profile in asymptomatic health care workers.. Valdivia Piqueres A, Torres Fink I, Huntley Pascual D, Alcaráz Soriana M, Albert Vicent E, Solano De La Asunción C, González Padrón C, Ferrer Dot J, Navarro Ortega D. Journal of Medical Virology. 2021 Feb;93(2):634-636. doi: 10.1002/jmv.26400. PMID: 32761912

Clinical outcomes of allogeneic hematopoietic stem cell transplant recipients developing Cytomegalovirus DNAemia prior to engraftment. Solano C, Vazquez L, Gimenez E, de la Camara R, Albert E, Rovira M, Espigado I, Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Pinana J, Navarro D, Spanish Group of Hematopoietic Transplantation and Cell Therapy (GETH). Bone Marrow Transplantation. 2021 Jun;56(6):1281-1290. doi: 10.1038/s41409-020-01157-x. PMID: 33319853

Complicacion infecciosa poco frecuente tras autoinyecciones intramusculares. Sanchez Ramos D, Pinto Pla C, De Gracia Leon A, Colomina Rodriguez J. Revista Espanola de Quimioterapia. 2021 Aug;34(4):393-395. doi: 10.37201/req/024.2021. PMID: 34049434

COVID-19 infodemics: the role of mainstream and social media. Focosi D, Navarro D, Maggi F, Roilides E, Antonelli G. Clinical microbiology and infection. 2021 Nov;27(11):1568-1569. doi: 10.1016/j.cmi.2021.08.003. PMID: 34375756

Cytomegalovirus DNAemia and risk of mortality in allogeneic hematopoietic stem cell transplantation: Analysis from the Spanish Hematopoietic Transplantation and Cell Therapy Group. Solano Vercet C, Vazquez L, Gimenez Quiles E, De La Camara R, Albert Vicent E, Rovira M, Espigado I, Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez Martinez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Bautista G, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Pinana J, Navarro Ortega D. American Journal of Transplantation. 2021 Jan;21(1):258-271. doi: 10.1111/ajt.16147. PMID: 32812351

Cytomegalovirus-specific T-cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib. De la Asuncion C, Terol M, Saus A, Olea B, Gimenez E, Albert E, Lopez-Jimenez J, Andreu R, Garcia D, Fox L, Remigia M, Amat P, Solano C, Navarro D. British Journal of Haematology. 2021 Nov;195(4):637-641. doi: 10.1111/bjh.17732. PMID: 34402042

Diagnostic significance of SARS-CoV-2 IgM positive/IgG negative antibody profile in symptomatic patients with suspected COVID-19 testing negative by RT-PCR. Valdivia Piqueres A, Torres Fink I, Huntley Pascual D, Alcaráz Soriana M, Albert Vicent E, González Padrón C, Colomina Rodríguez F, Navarro Ortega D. The Journal of infection. 2021 Jan;82(1):e15-e16. doi: 10.1016/j.jinf.2020.08.028. PMID: 32853600

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2021 Aug;93(8):5167-5172. doi: 10.1002/jmv.26661. PMID: 33174620

Evaluation of a rapid antigen detection test (Panbio (TM) COVID-19 Ag Rapid Test Device) as a point-of-care diagnostic tool for COVID-19 in a pediatric emergency department. Carbonell-Sahuquillo S, Lazaro-Carreno M, Camacho J, Barres-Fernandez A, Albert E, Torres I, Breton-Martinez J, Martinez-Costa C, Navarro D. Journal of Medical Virology. 2021 Dec;93(12):6803-6807. doi: 10.1002/jmv.27220. PMID: 34289136

Evaluation of a rapid antigen test (Panbio COVID-19 Ag rapid test device) for SARS-CoV-2 detection in asymptomatic close contacts of COVID-19 patients. Torres I, Poujois S, Albert E, Colomina J, Navarro D. Clinical microbiology and infection. 2021 Apr;27(4):636.e1-636.e4. doi: 10.1016/j.cmi.2020.12.022. PMID: 33421573

Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centers. Albert Vicent E, Torres Fink I, Bueno Ferrando F, Huntley Pascual D, Molla E, Fernandez-Fuentes M, Martínez López M, Poujois Gisbert S, Forqué Rodríguez L, Valdivia Piqueres A, Solano De La Asunción C, Ferrer Dot J, Colomina Rodríguez F, Navarro Ortega D. Clinical microbiology and infection. 2021 Mar;27(3):472.e7-472.e10. doi: 10.1016/j.cmi.2020.11.004. PMID: 33189872

Fundamentals and implementation of Microbiological Diagnostic Stewardship Programs. Bou G, Canton R, Martinez-Martinez L, Navarro Ortega D, Vila J. Enfermedades Infecciosas y Microbiologia Clinica. 2021 May;39(5):248-251. doi: 10.1016/j.eimc.2020.02.019. PMID: 32234252

Initial viral load and decay kinetics of SARS-CoV-2 lineage B.1.1.7 in the upper respiratory tract of adults and children. Costa R, Bueno F, Gimenez E, Bracho A, Albert E, Carretero D, de Michelena P, Martinez-Costa C, Gonzalez-Candelas F, Navarro D. Journal of Infection. 2021 Oct;83(4):496-522. doi: 10.1016/j.jinf.2021.08.015. PMID: 34390756

Kinetics of Torque Teno virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation. Bueno Ferrando F, Albert Vicent E, Pinana J, Perez Martinez A, Ubeda C, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Gimenez Quiles E, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant infectious disease. 2021 Jun;23(3):e13507. doi: 10.1111/tid.13507. PMID: 33176050

Lower respiratory tract and plasma SARS-CoV-2 RNA load in critically ill adult COVID-19 patients: Relationship with biomarkers of disease severity. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Infection. 2021 Sep;83(3):381-412. doi: 10.1016/j.jinf.2021.05.036. PMID: 34087349

Neisseria gonorrhoeae antimicrobial resistance in Spain: a prospective multicentre study. Salmeron P, Vinado B, Arando M, Alcoceba E, Romero B, Menendez B, Bernal S, Idigoras P, Colomina J, Martin-Saco G, Leal-Negredo A, Torreblanca A, Martinez O, Serra-Pladevall J. The Journal of Antimicrobial Chemotherapy. 2021 May 12;76(6):1523-1531. doi: 10.1093/jac/dkab037. PMID: 33569588

Qualitative assessment of SARS-CoV-2-specific antibody avidity by lateral flow immunochromatographic IgG/IgM antibody assay. Valdivia A, Torres I, Huntley D, Alcaraz M, Albert E, Colomina J, Ferrer J, Carratala A, Navarro D. Journal of Medical Virology. 2021 Feb;93(2):1141-1144. doi: 10.1002/jmv.26344. PMID: 32706420

SARS-CoV-2-reactive interferon-gamma-producing CD8+ T cells in patients hospitalized with Coronavirus Disease 2019. Gimenez Quiles E, Albert Vicent E, Torres Fink I, Remigia Pellicer M, Alcaráz Soriana M, Galindo Puerto M, Blasco Cortes M, Solano Vercet C, Forner Giner M, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):375-382. doi: 10.1002/jmv.26213. PMID: 32579268

SARS-CoV-2-specific cell-mediated immunity in kidney transplant recipients recovered from COVID-19. Fernandez-Ruiz M, Olea B, Gimenez E, Laguna-Goya R, Trujillo H, Caravaca-Fontan F, Gutierrez E, Lopez-Medrano F, Remigia M, Almendro-Vazquez P, Polanco N, Gonzalez E, Ruiz-Merlo T, Parra P, San Juan R, Andres A, Navarro D, Aguado J. Transplantation. 2021 Jun 1;105(6):1372-1380. doi: 10.1097/TP.0000000000003672. PMID: 33729741

Suitability of Two Rapid Lateral Flow Immunochromatographic Assays for Predicting SARS-CoV-2 Neutralizing Activity of Sera. Valdivia A, Torres I, Latorre V, Frances-Gomez C, Ferrer J, Forque L, Costa R, de la Asuncion C, Huntley D, Gozalbo-Rovira R, Buesa J, Gimenez E, Rodriguez-Diaz J, Geller R, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):2301-2306. doi: 10.1002/jmv.26697. PMID: 33236799

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant. Lopez M, Chiner-Oms A, Garcia de Viedma D, Ruiz-Rodriguez P, Bracho M, Cancino-Munoz I, D’Auria G, de Marco G, Garcia-Gonzalez N, Goig G, Gomez-Navarro I, Jimenez-Serrano S, Martinez-Priego L, Ruiz-Hueso P, Ruiz-Roldan L, Torres-Puente M, Alberola J, Albert Vicent E, Aranzamendi Zaldumbide M, Bea-Escudero M, Boga J, Bordoy A, Canut-Blasco A, Carvajal A, Cilla Eguiluz G, Cordon Rodriguez M, Costa-Alcalde J, de Toro M, de Toro Peinado I, Del Pozo J, Duchene S, Fernandez-Pinero J, Fuster Escriva B, Gimeno Cardona C, Gonzalez Galan V, Gonzalo Jimenez N, Hernaez Crespo S, Herranz M, Lepe J, Lopez-Causape C, Lopez-Hontangas J, Martin V, Martro E, Milagro Beamonte A, Montes Ros M, Moreno-Munoz R, Navarro Ortega D, Navarro-Mari J, Not A, Oliver A, Palop-Borras B, Parra Grande M, Pedrosa-Corral I, Perez Gonzalez M, Perez-Lago L, Perez-Ruiz M, Pineiro Vazquez L, Rabella N, Rezusta A, Robles Fonseca L, Rodriguez-Villodres A, Sanbonmatsu-Gamez S, Sicilia J, Soriano A, Tirado Balaguer M, Torres Fink I, Tristancho A, Marimon J, Coscolla M, Gonzalez-Candelas F, Comas I, SeqCOVID-Spain consortium. Nature Genetics. 2021 Oct;53(10):1405-1414. doi: 10.1038/s41588-021-00936-6. PMID: 34594042

Upper respiratory tract SARS-CoV-2 RNA loads in symptomatic and asymptomatic children and adults. Costa R, Bueno F, Albert E, Torres I, Carbonell-Sahuquillo S, Barres-Fernandez A, Sanchez D, Padron C, Colomina J, Lazaro Carreno M, Breton-Martinez J, Martinez-Costa C, Navarro D. Clinical Microbiology and Infection. 2021 Dec;27(12):1858.e1-1858.e7. doi: 10.1016/j.cmi.2021.08.001. PMID: 34384874

A new clinical and immuno-virological score for predicting the risk of late severe infection in solid organ transplant recipients: the CLIV Score. San-Juan R, Fernandez-Ruiz M, Ruiz-Ruigomez M, Lopez-Medrano F, Ruiz-Merlo T, Andres A, Loinaz C, Len O, Azancot M, Montejo M, Rodriguez-Alvarez R, Fortun J, Escudero-Sanchez R, Gimenez Quiles E, Lora D, Albert Vicent E, Navarro Ortega D, Aguado J, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016). The Journal of Infectious Diseases. 2020 Jul 6;222(3):479-487. doi: 10.1093/infdis/jiaa090. PMID: 32112085

An investigation of the utility of plasma Cytomegalovirus (CMV) microRNA detection to predict CMV DNAemia in allogeneic hematopoietic stem cell transplant recipients. Talaya Peñalver A, Gimenez Quiles E, Pascual M, Gago B, Piñana Sanchez J, Hernandez Boluda J, Vazquez L, Garcia M, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Medical Microbiology And Immunology. 2020 Feb;209(1):15-21. doi: 10.1007/s00430-019-00632-7. PMID: 31478067

Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell transplantation. Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Hernandez Boluda J, Gimenez Quiles E, Gomez M, Balaguer-Rosello A, Gonzalez-Barbera E, Guerreiro M, Aguilar C, Navarro Ortega D, Solano Vercet C, Sanz J, Luis Pinana J. Transplant Infectious Disease. 2020 Aug;22(4):e13301. doi: 10.1111/tid.13301. PMID: 32363665

Assessment of prevalence and load of torquetenovirus viraemia in a large cohort of healthy blood donors. Focosi D, Spezia P, Macera L, Salvadori S, Navarro Ortega D, Lanza M, Antonelli G, Pistello M, Maggi F. Clinical Microbiology and Infection. 2020 Oct;26(10):1406-1410. doi: 10.1016/j.cmi.2020.01.011. PMID: 31972321

Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens. Luis Pinana J, Albert Vicent E, Dolores Gomez M, Perez Martinez A, Hernandez Boluda J, Montoro J, Salavert M, Maria Gonzalez E, Tormo Diaz M, Gimenez Quiles E, Villalba M, Balaguer-Rosello A, Hernani Morales R, Bueno Ferrando F, Borras Salvador R, Sanz J, Solano Vercet C, Navarro Ortega D. The Journal of infection. 2020 May;80(5):578-606. doi: 10.1016/j.jinf.2020.01.001. PMID: 31926954

Co-detection of respiratory pathogens in patients hospitalized with Coronavirus viral disease-2019 pneumonia. Blasco Cortes M, Buesa Gomez J, Colomina Rodríguez F, Forner Giner M, Galindo Puerto M, Navarro Perez J, Noceda Bermejo J, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal Of Medical Virology. 2020 Oct;92(10):1799-1801. doi: 10.1002/jmv.25922. PMID: 32320082

Cytomegalovirus DNA load monitoring in stool specimens for anticipating the occurrence of intestinal acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: Is it of any value?. Bueno Ferrando F, Albert Vicent E, Gimenez Quiles E, Pinana J, Perez Martinez A, Gomez M, Hernandez Boluda J, Gonzalez-Barbera E, Montoro J, Guerreiro M, Balaguer-Rosello A, Hernani Morales R, Sanz J, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Aug 9;e13440. doi: 10.1111/tid.13440. PMID: 32772456

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Early kinetics of Torque Teno virus DNA load and BK polyomavirus viremia after kidney transplantation. Fernandez-Ruiz M, Albert Vicent E, Gimenez Quiles E, Rodriguez-Goncer I, Andres A, NAVARRO ORTEGA D, Maria Aguado J. Transplant infectious disease. 2020 Apr;22(2):e13240. doi: 10.1111/tid.13240. PMID: 31883425

Features of Cytomegalovirus DNAemia Blips in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Implications for Optimization of Preemptive Antiviral Therapy Strategies. Huntley Pascual D, Talaya Peñalver A, Gimenez Quiles E, Perez Martinez A, Hernandez Boluda J, Hernani Morales R, Torres Fink I, Alberola J, Albert Vicent E, Piñana Sanchez J, Solano Vercet C, Navarro Ortega D. Biology of Blood and Marrow Transplantation. 2020 May;26(5):972-977. doi: 10.1016/j.bbmt.2020.01.015. PMID: 32007638

Field Performance of the Abbott RealTime MTB Assay for the Diagnosis of Extrapulmonary Tuberculosis in a Low-Prevalence Setting. Borrás R, Martínez V, Vinuesa V, Torres I, Orta N, Clari MA, Prat J, Navarro D. Enfermedades Infecciosas Y Microbiologia Clinica. 2020 May;38(5):206-211. doi: 10.1016/j.eimc.2019.08.007. PMID: 31668859

Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with post-transplantation cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Jesus Pascual M, Hernandez Boluda J, Gago B, Vazquez Lopez L, Luis Pinana J, Garcia M, Perez Martinez A, Serrano D, Hernandez M, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Transplant Infectious Disease. 2020 Feb;22(1):e13206. doi: 10.1111/tid.13206. PMID: 31677215

Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: some nuances. Aguilar Aguilar G, Ferriols Lisart R, Martínez Castro S, Ezquer Garin C, Pastor Martinez E, Carbonell Lopez J, Alos Almiñana M, Navarro Ortega D. Critical Care. 2020 Jan 10;24(1):11. doi: 10.1186/s13054-019-2724-y. PMID: 31924240

Peripheral blood regulatory T cells and occurrence of Cytomegalovirus DNAemia after unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Vázquez L, Amat Martínez P, Remigia Pellicer M, Hernández M, Hernandez Boluda J, Gago B, Piñana Sanchez J, García M, Perez Martinez A, Alberola J, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1493-1496. doi: 10.1038/s41409-020-0950-1. PMID: 32447351

Pooling of Nasopharyngeal Swab Specimens for SARS-CoV-2 detection by RT-PCR. Torres Fink I, Albert Vicent E, Navarro Ortega D. Journal of Medical Virology. 2020 Nov;92(11):2306-2307. doi: 10.1002/jmv.25971. PMID: 32369202

Reconstitution of cytomegalovirus-specific T-cell immunity following unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Huntley Pascual D, Gimenez Quiles E, Pascual M, Remigia Pellicer M, Amat Martínez P, Vazquez Lopez L, Hernandez M, Hernandez Boluda J, Gago B, Piñana Sanchez J, Garcia M, Perez Martinez A, Mateo Jimenez E, Gozalbo-Rovira R, Albert Vicent E, Solano Vercet C, Navarro Ortega D. Bone Marrow Transplantation. 2020 Jul;55(7):1347-1356. doi: 10.1038/s41409-020-0865-x. PMID: 32205853

SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patients. Gozalbo-Rovira R, Gimenez Quiles E, Latorre V, Frances-Gomez C, Albert Vicent E, Buesa Gomez J, Marina A, Blasco Cortes M, Signes-Costa Miñana J, Rodriguez Diaz J, Geller R, Navarro Ortega D. Journal of Clinical Virology. 2020 Oct;131:104611. doi: 10.1016/j.jcv.2020.104611. PMID: 32882666

The clinical benefit of instituting a prospective clinical community-acquired respiratory virus surveillance program in allogeneic hematopoietic stem cell transplantation. Pinana J, Montoro J, Aznar C, Lorenzo I, Dolores Gomez M, Guerreiro M, Carretero C, Maria Gonzalez-Barbera E, Balaguer-Rosello A, Sanz R, Salavert M, Navarro Ortega D, Sanz M, Sanz G, Sanz J. The Journal of infection. 2020 Mar;80(3):333-341. doi: 10.1016/j.jinf.2019.12.022. PMID: 31972212

The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey. Pinana J, Perez Martinez A, Montoro J, Hernani Morales R, Lorenzo I, Gimenez Quiles E, Gomez M, Guerreiro M, Gonzalez-Barbera E, Carretero C, Salavert M, Balaguer-Rosello A, Sanz G, Hernandez Boluda J, Solano Vercet C, Sanz J, Navarro Ortega D. Bone Marrow Transplantation. 2020 Feb;55(2):431-440. doi: 10.1038/s41409-019-0698-7. PMID: 31551521

Torque teno virus viremia in patients with chronic arthritis: Influence of biologic therapies. Martin-Lopez M, Albert Vicent E, Fernandez-Ruiz M, Gonzalez-Alvaro I, Rodriguez E, Aguado J, Navarro Ortega D, Pablos J. Seminars in Arthritis and Rheumatism. 2020 Feb;50(1):166-171. doi: 10.1016/j.semarthrit.2019.06.019

Uniform graft-versus-host disease prophylaxis with posttransplant cyclophosphamide, sirolimus, and mycophenolate mofetil following hematopoietic stem cell transplantation from haploidentical, matched sibling and unrelated donors. Montoro J, Pinana J, Hernandez Boluda J, Hernani Morales R, Lorenzo I, Perez Martinez A, Guerreiro M, Balaguer-Rosello A, Sanz G, Carretero C, Albert Vicent E, Navarro Ortega D, Sanz M, Solano Vercet C, Sanz J. Bone Marrow Transplantation. 2020 Nov;55(11):2147-2159. doi: 10.1038/s41409-020-0921-6. PMID: 32371901

Proyectos
Referencia: PI21/00563
Título: Inmunidad adaptativa de linfocitos B y T frente a SARS-CoV-2 tras la vacunación de pacientes en riesgo de sufrir COVID-19 severa
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: David Navarro Ortega, Estela Giménez
Duración: 2022 – 2024
Presupuesto: 169.400 €
Estudio de cohortes observacional y prospectivo para evaluar la magnitud y la durabilidad de las respuestas adaptativas de las células B y T contra el SARS-CoV-2 tras la vacunación en población de alto riesgo de COVID-19 grave. Además, las variantes del SARS-CoV-2 que causan infección en personas vacunadas se caracterizarán por secuenciación de alto rendimiento.
Referencia: 896932-TTVGuideTX
Título: Personalisation of immunosuppression by monitoring viral load post kidney transplantation – a randomised controlled phase II trial
Entidad Financiadora: European Commission
Investigador principal: David Navarro Ortega
Duración: 2021 – 2026
Presupuesto: 85.625 €
Referencia: PI-2021-004
Título: TECO: Validación de dos sistemas biosensor para la diagnosis simultánea de covid19 y otros patógenos aéreos
Entidad Financiadora: Universidad de Valencia – INCLIVA
Investigador principal: David Giménez Romero, Estela Giménez Quiles
Duración: 2021 – 2022
Presupuesto: 19.000 €
Referencia: PI18/00127
Título: Virología e inmunología de la infección por el citomegalovirus (CMV) en el paciente con neoplasia hematológicas en la era de las nuevas bioterapias
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: David Navarro Ortega
Duración: 2019 – 2022
Presupuesto: 111.320 €
Referencia: PI15/00090
Título: Inmunobiología de la infección por el citomegalovirus en el trasplante alogénico de precursores hematopoyéticos haploidéntico asociado al uso de ciclofosfamida postrasplante
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: David Navarro Ortega
Duración: 2016 – 2019
Presupuesto: 98.615 €
+ Información
Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7). Ljungman P, de la Camara R, Robin C, Crocchiolo R, Einsele H, Hill JA6, Hubacek P7, Navarro D8, Cordonnier C3, Ward KN9; 2017 European Conference on Infections in Leukaemia group. LANCET INFECTIOUS DISEASES. 2019 Aug; 19(8): e260-e272. doi: 10.1016/S1473-3099(19)30107-0. PMID: 31153807

Título: Factores predictivos de desarrollo y evolución de infección activa por citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
Doctorando: Vinuesa Velasco, Víctor
Director: Navarro Ortega, David
Fecha: 08/09/2021
Universidad: Universitat de València

Título: Parámetros biológicos predictivos de la infección activa precoz por Citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
Doctorando: Talaya Peñalver, Alberto
Director: Navarro Ortega, David
Fecha: 26/05/2021
Universidad: Universitat de València

Título: Desarrollo de un dispositivo médico tipo «point of care» para la detección rápida de infección urinaria y sensibilidad antibiótica en países en vías de desarrollo
Doctorando: Jover García, Jorge
Director: Colomina Rodríguez, Javier
Fecha: 12/03/2021
Universidad: Universitat de València

Título: Vigilancia de la susceptibilidad antibiótica y caracterización genotípica de aislados de Neisseria Gonorrhoeae en la Comunidad Valenciana: proyecto multicéntrico GONOvig
Doctorando: Fabregat Bolufer, Aleix Borja
Director: Colomina Rodríguez, Javier
Fecha: 26/02/2021
Universidad: Universitat de València

Título: Torque teno virus como marcador subrogado de inmunocompetencia en el trasplante
Doctorando: Albert Vicent, Eliseo
Director: Navarro Ortega, David
Fecha: 13/02/2020
Universidad: Universitat de València

Título: Concentración mínima inhibitoria de vancomicina para staphylococcus aureus y riesgo de bacteriemia complicada
Doctorando: Falcón Abad, Rocío
Director: Navarro Ortega, David
Fecha: 02/10/2019
Universidad: Universitat de València