Grupo de Investigación en Envejecimiento Saludable (MiniAging)

Área de Metabolismo y Daño Orgánico

Conocer los mecanismos moleculares implicados en los procesos de envejecimiento y fragilidad

Desarrollar posibles biomarcadores para evaluarlos

Desarrollar posibles métodos para evaluarlos

Desarrollar estrategias de intervención adecuadas

Determinar un índice de calidad de vida en animales de experimentación

Desarrollar biomarcadores de imagen humana para el diagnóstico de la fragilidad

Estudiar intervenciones para retrasar el envejecimiento y prevenir la fragilidad

– Terapia con pequeñas vesículas extracelulares

– Papel del gen antiapoptótico Bcl-xL

Dra. Consuelo Borrás Blasco
Dra. Consuelo Borrás Blasco

R4 Senior
R3 Consolidado

Consuelo Borrás Blasco    

R2 Novel / Emergente

Ana Díaz Cuevas
Cristina Mas Bargues
Jorge Sanz Ros
Mar Dromant Jarque
Marta Inglés de la Torre

R1 Predoctoral

Javier Huete Acevedo

Effects of a low-pressure hyperbaric oxygen therapy on psychological constructs related to pain and quality of life in women with fibromyalgia: A randomized clinical trial. Izquierdo-Alventosa R, Ingles M, Cortes-Amador S, Munoz-Gomez E, Molla-Casanova S, Gimeno-Mallench L, Chrivella-Garrido J, Serra-Ano P. Medicina Clinica. 2024 Feb 20:S0025-7753(24)00033-2. doi: 10.1016/j.medcli.2023.12.016. PMID: 38383268

Effects of an oral stimulation program on feeding outcomes in preterm infants: a systematic review and meta-analysis. Munoz-Gomez E, Ingles M, Molla-Casanova S, Sempere-Rubio N, Serra-Ano P, Aguilar-Rodriguez M. Physical & Occupational Therapy in Pediatrics. 2024;44(1):110-127. doi: 10.1080/01942638.2023.2212767. PMID: 37203152

Effects of mirror neuron activation therapies on functionality in older adults: systematic review and meta-analysis. Molla-Casanova S, Page A, Lopez-Pascual J, Ingles M, Sempere-Rubio N, Aguilar-Rodriguez M, Munoz-Gomez E, Serra-Ano P. Geriatric Nursing. 2024 Feb 10:56:115-123. doi: 10.1016/j.gerinurse.2024.02.006. PMID: 38346365

Altered lipid moieties and carbonyls in a wistar rat dietary model of subclinical fatty liver: potential sex-specific biomarkers of early fatty liver disease?. Martín-Grau M, Pardo-Tendero M, Casanova P, Dromant M, Marrachelli V, Morales J, Borrás C, Pisoni S, Maestrini S, Di Blasio A, Monleon D. Antioxidants. 2023 Sep 28;12(10):1808. doi: 10.3390/antiox12101808. PMID: 37891887

Assessment and risk prediction of frailty using texture-based muscle ultrasound image analysis and machine learning techniques. Miron-Mombiela R, Ruiz-Espana S, Moratal D, Borras C. Mechanisms of Ageing and Development. 2023 Sep 4;215:111860. doi: 10.1016/j.mad.2023.111860. PMID: 37666473

Changes in the extracellular matrix at microvascular obstruction area after reperfused myocardial infarction: A morphometric study. Blazquez-Bujeda A, Ortega M, de Dios E, Gavara J, Perez-Sole N, Molina-Garcia T, Marcos-Garces V, Diaz A, Chorro F, Rios-Navarro C, Bodi V, Ruiz-Sauri A. Annals of Anatomy-Anatomischer Anzeiger. 2023 Jul 26;250:152138. doi: 10.1016/j.aanat.2023.152138. PMID: 37506775

Effect of non-specific neck pain on the path of the instantaneous axis of rotation of the neck during its flexion-extension movement. Page A, Ingles M, Venegas W, Molla-Casanova S, Serra-Ano P. Musculoskeletal Science & Practice. 2023 Feb 28;64:102737. doi: 10.1016/j.msksp.2023.102737. PMID: 36871441

Effect of virtual running with exercise on functionality in pre-frail and frail elderly people: randomized clinical trial. Molla-Casanova S, Munoz-Gomez E, Sempere-Rubio N, Ingles M, Aguilar-Rodriguez M, Page A, Lopez-Pascual J, Serra-Ano P. Aging Clinical and Experimental Research. 2023 Jul;35(7):1459-1467. doi: 10.1007/s40520-023-02414-x. PMID: 37188994

Effectiveness of a manual therapy protocol in women with pelvic pain due to endometriosis: a randomized clinical trial. Munoz-Gomez E, Alcaraz-Martinez A, Molla-Casanova S, Sempere-Rubio N, Aguilar-Rodriguez M, Serra-Ano P, Ingles M. Journal of Clinical Medicine. 2023 May 6;12(9):3310. doi: 10.3390/jcm12093310. PMID: 37176750

Effects of mirror therapy on pain, sensitivity and functionality in patients with unilateral carpal tunnel syndrome. Randomised control trial. Munoz-Gomez E, Aguilar-Rodriguez M, Ingles M, Molla-Casanova S, Sempere-Rubio N, Serra-Ano P. Disability and Rehabilitation. 2023 Nov 10:1-9. doi: 10.1080/09638288.2023.2280705. PMID: 37947269

Effects of mirror therapy on spasticity and sensory impairment after stroke: systematic review and meta-analysis. Munoz Gomez E, Ingles M, Aguilar Rodriguez M, Sempere Rubio N, Molla Casanova S, Serra Ano P. PM & R. 2023 Nov;15(11):1478-1492. doi: 10.1002/pmrj.12964. PMID: 36787183

Extracellular vesicles as therapeutic resources in the clinical environment. Sanz Ros J, Mas Bargues C, Romero Garcia N, Huete Acevedo J, Dromant M, Borras C. International Journal of Molecular Sciences. 2023 Jan 25;24(3):2344. doi: 10.3390/ijms24032344. PMID: 36768664

Extracellular Vesicles as Very Important Particles (VIPs) in Aging. Mas Bargues C, Alique M. International Journal of Molecular Sciences. 2023 Feb 20;24(4):4250. doi: 10.3390/ijms24044250. PMID: 36835661

Extracellular vesicles: the future of diagnosis in solid organ transplantation?. Romero-Garcia N, Huete-Acevedo J, Mas-Bargues C, Sanz-Ros J, Dromant M, Badenes R, Borras C. International Journal of Molecular Sciences. 2023 Mar 7;24(6):5102. doi: 10.3390/ijms24065102. PMID: 36982182

Fibromyalgia syndrome is associated with sexual dysfunction regardless of physical activity status: a cross-sectional study. Mollà-Casanova S, Muñoz-Gómez E, Sempere-Rubio N, Inglés M, Aguilar-Rodríguez M, Moreno-Cervera N, Serra-Añó P. Journal of Sexual Medicine. 2023 Oct 31;20(11):1285-1291. doi: 10.1093/jsxmed/qdad121. PMID: 37740987

Immediate effects of a single session of cervical spine manipulation on cervical movement patterns in people with nonspecific neck pain: a randomized controlled trial. Serra-Ano P, Venegas W, Page A, Ingles de la Torre M, Aguilar-Rodriguez M, Espi-Lopez G. Journal of Manipulative and Physiological Therapeutics. 2023 Jan;46(1):17-26. doi: 10.1016/j.jmpt.2023.05.006. PMID: 37422751

Impact of physical activity levels on the ability to maintain static trunk posture in older adults. Sempere-Rubio N, Munoz-Gomez E, Ingles M, Aguilar-Rodriguez M, Molla-Casanova S, Serra-Ano P. Geriatric Nursing. 2023 May 25;52:24-30. doi: 10.1016/j.gerinurse.2023.05.005. PMID: 37243989

Mitochondria pleiotropism in stem cell senescence: mechanisms and therapeutic approaches. Mas-Bargues C. Free Radical Biology & Medicine. 2023 Nov 1:208:657-671. doi: 10.1016/j.freeradbiomed.2023.09.019. PMID: 37739140

Oxidative stress, atherogenic dyslipidemia, and cardiovascular risk. Vekic J, Stromsnes K, Mazzalai S, Zeljkovic A, Rizzo M, Gambini J. Biomedicines. 2023 Oct 26;11(11):2897. doi: 10.3390/biomedicines11112897. PMID: 38001900

Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome. Sol J, Obis E, Mota Martorell N, Pradas I, Galo Licona J, Martin Gari M, Fernandez Bernal A, Ortega Bravo M, Mayneris Perxachs J, Borras C, Vina J, de la Fuente M, Mate I, Biarnes C, Pedraza S, Vilanova J, Brugada R, Ramos R, Serena J, Ramio-Torrenta L, Pineda V, Daunis I Estadella P, Thio Henestrosa S, Barretina J, Garre Olmo J, Portero Otin M, Fernandez Real J, Puig J, Jove M, Pamplona R. Aging Cell. 2023 Jun;22(6):e13821. doi: 10.1111/acel.13821. PMID: 36951231

Pomegranate extract administration reverses loss of motor coordination and prevents oxidative stress in cerebellum of aging mice. Verdú D, Valls A, Díaz A, Carretero A, Dromant M, Kuligowski J, Serna E, Viña J. Antioxidants. 2023 Nov 11;12(11):1991. doi: 10.3390/antiox12111991. PMID: 38001844

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein-energy malnutrition in predementia aged people: study protocol for Choko-Age. Pedrinolla A, Isanejad M, Antognelli C, Bartolini D, Borras C, Cavedon V, Di Sante G, Migni A, Mas-Bargues C, Milanese C, Baschirotto C, Modena R, Pistilli A, Rende M, Schena F, Stabile AM, Telesa NV, Tortorella S, Hemmings K, Vina J, Wang E, McArdle A, Jackson MJ, Venturelli M, Galli F. BMJ Open. 2023 Dec 22;13(12):e072291. doi: 10.1136/bmjopen-2023-072291. PMID: 38135320

Sex-related differences in migraine clinical features by frequency of occurrence: a cross-sectional study. Munoz Gomez E, Aguilar Rodriguez M, Serra Ano P, Sempere Rubio N, Molla Casanova S, Ingles M. Scandinavian Journal of Pain. 2023 May 15;23(3):553-562. doi: 10.1515/sjpain-2022-0152. PMID: 37184993

Small extracellular vesicles from senescent stem cells trigger adaptive mechanisms in young stem cells by increasing antioxidant enzyme expression. Mas-Bargues C, Sanz-Ros J, Romero-Garcia N, Huete-Acevedo J, Dromant M, Borras C. Redox Biology. 2023 Jun:62:102668. doi: 10.1016/j.redox.2023.102668. PMID: 36965438

The double-edged role of extracellular vesicles in the hallmarks of aging. Romero-Garcia N, Huete-Acevedo J, Mas-Bargues C, Sanz-Ros J, Dromant M, Borras C. Biomolecules. 2023 Jan 13;13(1):165. doi: 10.3390/biom13010165. PMID: 36671550

The potential use of mitochondrial extracellular vesicles as biomarkers or therapeutical tools. Sanz-Ros J, Mas-Bargues C, Romero-Garcia N, Huete-Acevedo J, Dromant M, Borras C. International Journal of Molecular Sciences. 2023 Apr 10;24(8):7005. doi: 10.3390/ijms24087005. PMID: 37108168

The role of extracellular vesicles in aging and disease. Borrás C, Mas-Bargues C. International Journal of Molecular Sciences. 2023 Sep 6;24(18):13739. doi: 10.3390/ijms241813739. PMID: 37762042

Author response to Ilgen, U. Alventosa R, Ingles M, Amador S, Mallench L, Rubio N, Ano P. Physical Therapy. 2022 Aug 4;102(8):pzac072. doi: 10.1093/ptj/pzac072. PMID: 35713527

Blood DNA methylation patterns in older adults with evolving dementia. Fernandez Perez R, Alba Linares JJ, Tejedor JR, Fernandez Fernandez A, Calero M, Roman Dominguez A, Borras C, Vina J, Avila J, Medina M, Fernandez Fraga M. The journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Sep 1;77(9):1743-1749. doi: 10.1093/gerona/glac068. PMID: 35299244

Effect of a craniosacral therapy protocol in people with migraine: a randomized controlled trial. Munoz-Gomez E, Ingles M, Aguilar-Rodriguez M, Molla-Casanova S, Sempere-Rubio N, Serra-Ano P, Espi-Lopez G. Journal of Clinical Medicine. 2022 Jan 30;11(3):759. doi: 10.3390/jcm11030759. PMID: 35160211

Effects of foam rolling vs. manual therapy in patients with tension-type headache: a randomized pilot study. Espi-Lopez G, Ingles M, Carrasco-Fernandez J, Serra-Ano P, Copete-Fajardo L, Gonzalez-Gerez J, Saavedra-Hernandez M, Marques-Sule E. Journal of Clinical Medicine. 2022 Mar 23;11(7):1778. doi: 10.3390/jcm11071778. PMID: 35407385

Fourier analysis of collagen bundle orientation in myocardial infarction scars. Marcos-Garces V, Rios-Navarro C, Gomez-Torres F, Gavara J, de Dios E, Diaz A, Minana G, Chorro F, Bodi V, Ruiz-Sauri A. Histochemistry and Cell Biology. 2022 Nov;158(5):471-483. doi: 10.1007/s00418-022-02132-x. PMID: 35948735

Functional transcriptomic analysis of centenarians’ offspring reveals a specific genetic footprint that may explain that they are less frail than age-matched non-centenarians’ offspring. Ingles M, Belenguer-Varea A, Serna E, Mas-Bargues C, Tarazona-Santabalbina F, Borras C, Vina J. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Oct 6;77(10):1931-1938. doi: 10.1093/gerona/glac119. PMID: 35640160

Genistein effect on cognition in prodromal Alzheimer’s disease patients. The GENIAL clinical trial. Vina J, Escudero J, Baquero M, Cebrian M, Carbonell-Asins J, Munoz J, Satorres E, Melendez J, Ferrer-Rebolleda J, Cozar-Santiago M, Santabarbara-Gomez J, Jove M, Pamplona R, Tarazona-Santabalbina F, Borras C. Alzheimers Research & Therapy. 2022 Nov 4;14(1):164. doi: 10.1186/s13195-022-01097-2. PMID: 36329553

Genistein, a tool for geroscience. Bargues C, Borras C, Vina J. Mechanisms of Ageing and Development. 2022 Jun;204:111665. doi: 10.1016/j.mad.2022.111665. PMID: 35307412

Long-lived humans have a unique plasma sphingolipidome. Pradas I, Jove M, Huynh K, Ingles M, Borras C, Mota-Martorell N, Galo-Licona JD, Puig J, Vina J, Meikle PJ, Pamplona R. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Apr 1;77(4):728-735. doi: 10.1093/gerona/glab360. PMID: 34871393

Oxidative stress and inflammation: from mechanisms to therapeutic approaches. Gambini J, Stromsnes K. Biomedicines. 2022 Mar 23;10(4):753. doi: 10.3390/biomedicines10040753. PMID: 35453503

Potential add-on effects of manual therapy techniques in migraine patients: a randomised controlled trial. Munoz-Gomez E, Serra-Ano P, Molla-Casanova S, Sempere-Rubio N, Aguilar-Rodriguez M, Espi-Lopez G, Ingles M. Journal of Clinical Medicine. 2022 Aug 11;11(16):4686. doi: 10.3390/jcm11164686. PMID: 36012924

Recent approaches to determine static and dynamic redox state-related parameters. Mas-Bargues C, Garcia-Dominguez E, Borras C. Antioxidants. 2022 Apr 28;11(5):864. doi: 10.3390/antiox11050864. PMID: 35624728

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice. Sanz-Ros J, Romero-Garcia N, Mas-Bargues C, Monleon D, Gordevicius J, Brooke RT, Dromant M, Diaz A, Derevyanko A, Guio-Carrion A, Roman-Dominguez A, Ingles M, Blasco MA, Horvath S, Vina J, Borras C. Science Advances. 2022 Oct 21;8(42):eabq2226. doi: 10.1126/sciadv.abq2226. PMID: 36260670

Special issue «Oxidative stress in aging and associated chronic diseases». Mas-Bargues C, Alique M, Barrús-Ortiz MT, Borrás C, Rodrigues-Díez R. Antioxidants. 2022 Apr 2;11(4):701. doi: 10.3390/antiox11040701. PMID: 35453386

The contribution of extracellular vesicles from senescent endothelial and vascular smooth muscle cells to vascular calcification. Mas-Bargues C, Borras C, Alique M. Frontiers In Cardiovascular Medicine. 2022 Apr 15;9:854726. doi: 10.3389/fcvm.2022.854726. PMID: 35498012

The multimodal action of genistein in Alzheimer’s and other age-related diseases. Mas-Bargues C, Borras C, Vina J. Free Radical Biology & Medicine. 2022 Apr;183:127-137. doi: 10.1016/j.freeradbiomed.2022.03.021. PMID: 35346775

Therapeutic potential of extracellular vesicles in aging and age-related diseases. Sanz-Ros J, Mas-Bargues C, Romero-Garcia N, Huete-Acevedo J, Dromant M, Borras C. International Journal of Molecular Sciences. 2022 Nov 23;23(23):14632. doi: 10.3390/ijms232314632. PMID: 36498960

Transcriptomic profile of epileptic children treated with ketogenic therapies. Ruiz-Herrero J, Olaso-Gonzalez G, Serna E, Canedo-Villarroya E, Correas A, Gambini J, Gomez-Cabrera M, Pedron-Giner C, Vina J. Journal of Integrative Neuroscience. 2022 Jan 28;21(1):31. doi: 10.31083/j.jin2101031. PMID: 35164467

What genetics can do for oncological imaging: a systematic review of the genetic validation data used in radiomics studies. Mombiela R, Arildskov A, Bruun F, Hasselbalch L, Holst K, Rasmussen S, Borras C. International Journal of Molecular Sciences. 2022 Jun 10;23(12):6504. doi: 10.3390/ijms23126504. PMID: 35742947

A natural xenogeneic endometrial extracellular matrix hydrogel toward improving current human in vitro models and future in vivo applications. Lopez-Martinez S, Campo H, de Miguel-Gomez L, Faus A, Navarro A, Diaz A, Pellicer A, Ferrero H, Cervello I. Frontiers in Bioengineering and Biotechnology. 2021 Mar 5;9:639688. doi: 10.3389/fbioe.2021.639688. PMID: 33748086

Anti-inflammatory properties of diet: role in healthy aging.Stromsnes K, Correas A, Lehmann J, Gambini J, Olaso-Gonzalez G. Biomedicines. 2021 Jul 30;9(8):922. doi: 10.3390/biomedicines9080922. PMID: 34440125

Attitudes towards learning professional ethics in undergraduate physiotherapy students: A STROBE compliant cross-sectional study. Marques-Sule E, Arnal-Gomez A, Cortes-Amador S, de la Torre M, Hernandez D, Aguilar-Rodriguez M. Nurse Education Today. 2021 Mar;98:104771. doi: 10.1016/j.nedt.2021.104771. PMID: 33529858

Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395

Bioengineered endometrial hydrogels with growth factors promote tissue regeneration and restore fertility in murine models. Lopez-Martinez S, Rodriguez-Eguren A, de Miguel-Gomez L, Frances-Herrero E, Faus A, Diaz A, Pellicer A, Ferrero H, Cervello I. Acta Biomaterialia. 2021 Nov;135:113-125. doi: 10.1016/j.actbio.2021.08.025. PMID: 34428563

Biomechanical and viscoelastic properties of the ankle muscles in men with previous history of ankle sprain. Serra-Ano P, Ingles M, Espi-Lopez G, Sempere-Rubio N, Aguilar-Rodriguez M. Journal of Biomechanics. 2021 Jan 22;115:110191. doi: 10.1016/j.jbiomech.2020.110191. PMID: 33385869

Decellularized tracheal prelamination implant: A proposed bilateral double organ technique. Martinez-Hernandez N, Diaz-Cuevas A, Milian-Medina L, Sancho-Tello M, Rosello-Ferrando J, Morcillo-Aixela A, Campo-Canaveral J, Roig-Bataller A, Mata-Roig M. Artificial Organs. 2021 Dec;45(12):1491-1500. doi: 10.1111/aor.14043. PMID: 34310703

Diagnostic performance of muscle echo intensity and fractal dimension for the detection of frailty phenotype. Miron Mombiela R, Vucetic J, Monllor P, Cardenas-Herran JS, Taltavull de la Paz P, Borras C. Ultrasonic Imaging. 2021 Nov;43(6):337-352. doi: 10.1177/01617346211029656. PMID: 34238072

Domestic pig prioritized in one health action against fascioliasis in human endemic areas: Experimental assessment of transmission capacity and epidemiological evaluation of reservoir role. Mas-Coma S, Funatsu IR, Angles R, Buchon P, Mas Bargues C, Artigas P, Valero MA, Bargues MD. One Health. 2021 Apr 16;13:100249. doi: 10.1016/j.onehlt.2021.100249. PMID: 33997234

Effectiveness of a manual therapy protocol based on articulatory techniques in migraine patients. A randomized controlled trial. Munoz-Gomez E, Ingles M, Serra-Ano P, Espi-Lopez GV. Musculoskeletal Science & Practice. 2021 Apr 30;54:102386. doi: 10.1016/j.msksp.2021.102386. PMID: 33989990

Effectiveness of high-frequency transcranial magnetic stimulation and physical exercise in women with fibromyalgia: a randomized controlled trial. Izquierdo-Alventosa R, Ingles M, Cortes-Amador S, Gimeno-Mallench L, Sempere-Rubio N, Serra-Ano P. Physical Therapy & Rehabilitation Journal. 2021 Oct 1;101(10):pzab159. doi: 10.1093/ptj/pzab159. PMID: 34216139

Effects of balance training on functionality, ankle instability, and dynamic balance outcomes in people with chronic ankle instability: Systematic review and meta-analysis. Molla-Casanova S, Ingles M, Serra-Ano P. Clinical Rehabilitation. 2021 Dec;35(12):1694-1709. doi: 10.1177/02692155211022009. PMID: 34058832

Efficacy of a proprioceptive exercise program in patients with nonspecific neck pain. A randomized controlled trial. Espí López G, Aguilar Rodríguez M, Zarzoso Muñoz M, Serra Año M, Martinez De La Fuente J, Inglés De La Torre M, Marques-Sule E. European Journal of Physical and Rehabilitation Medicine. 2021 Jun;57(3):397-405. doi: 10.23736/S1973-9087.20.06302-9. PMID: 33047944

Estrogen replacement therapy induces antioxidant and longevity-related genes in women after medically induced menopause. Borras C, Ferrando M, Ingles M, Gambini J, Lopez-Grueso R, Edo R, Mas-Bargues C, Pellicer A, Vina J. Oxidative Medicine and Cellular Longevity. 2021 Sep 9;2021:8101615. doi: 10.1155/2021/8101615. PMID: 34539974

Exploring new kingdoms: the role of extracellular vesicles in oxi-inflamm-aging related to cardiorenal syndrome. Mas-Bargues C, Alique M, Barrus-Ortiz M, Borras C, Rodrigues-Diez R. Antioxidants. 2021 Dec 29;11(1):78. doi: 10.3390/antiox11010078. PMID: 35052582

Importance of stem cell culture conditions for their derived extracellular vesicles therapeutic effect. Mas-Bargues C, Borras C. Free Radical Biology & Medicine. 2021 May 20;168:16-24. doi: 10.1016/j.freeradbiomed.2021.03.028. PMID: 33781893

Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Borras C, Abdelaziz KM, Diaz A, Gambini J, Jove M, Lopez-Grueso R, Mas-Bargues C, Monleon D, Pamplona R, Vina J. Mechanisms of Ageing and Development. 2021 Dec;200:111596. doi: 10.1016/j.mad.2021.111596. PMID: 34774606

Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Mas-Bargues C, Escrivá C, Dromant M, Borrás C, Viña J. Archives of Biochemistry and Biophysics. 2021 Sep 30;709:108941. doi: 10.1016/ PMID: 34097903

Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Gambini J, Gimeno-Mallench L, Olaso-Gonzalez G, Mastaloudis A, Traber M, Monleon D, Borras C, Vina J. Antioxidants. 2021 Feb 16;10(2):301. doi: 10.3390/antiox10020301. PMID: 33669360

Pharmacological properties of polyphenols: bioavailability, mechanisms of action, and biological effects in in vitro studies, animal models, and humans. Stromsnes K, Lagzdina R, Olaso-Gonzalez G, Gimeno-Mallench L, Gambini J. Biomedicines. 2021 Aug 23;9(8):1074. doi: 10.3390/biomedicines9081074. PMID: 34440278

Role of antiangiogenic VEGF-A165b in angiogenesis and systolic function after reperfused myocardial infarction. Rios Navarro C, Hueso Soler L, Diaz Cuevas A, Marcos Garcés V, Bonanad Lozano C, Ruiz Sauri A, Vila Salinas J, Sanz Ferrando M, Chorro Gascó F, Piqueras Ruiz L, Bodí Peris V. Revista espanola de Cardiologia (English ed.). 2021 Feb;74(2):131-139. doi: 10.1016/j.rec.2020.03.013. PMID: 32474003

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates. Duro-Castano A, Borras C, Herranz-Perez V, Blanco-Gandia M, Conejos-Sanchez I, Arminan A, Mas-Bargues C, Ingles M, Minarro J, Rodriguez-Arias M, Garcia-Verdugo J, Vina J, Vicent M. Science Advances. 2021 Mar 26;7(13):eabf9180. doi: 10.1126/sciadv.abf9180. PMID: 33771874

Thermal imaging ruled out as a supplementary assessment in patients with fibromyalgia: a cross-sectional study. Sempere-Rubio N, Aguilar-Rodriguez M, Ingles M, Izquierdo-Alventosa R, Serra-Ano P. PLoS One. 2021 Jun 16;16(6):e0253281. doi: 10.1371/journal.pone.0253281. PMID: 34133467

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. NCD Risk Factor Collaboration. Lancet. 2021 Sep 11;398(10304):957-980. doi: 10.1016/S0140-6736(21)01330-1. PMID: 34450083

Referencia: GE/2022/134
Título: Papel de BCL-Xl en el envejecimiento saludable y la prevención de la fragilidad
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: Cristina Más Bargues
Duración: 2022 – 2023
Presupuesto: 20.000 €
Referencia: CHOKO-AGE AC20/00026
Título: Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK of protein energy malnutrition in pre-dementia AGEd people. ERA-HDHL Call for Joint Transnational Research Proposals on Development of targeted nutrition for prevention of undernutrition for older adults (PREVNUT)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: José Viña Ribes
Duración: 2021 – 2023
Presupuesto: 169.098 €
Referencia: PID2020-113839RB-I00
Título: Efecto del tratamiento con vesículas extracelulares de células madre de grasa de ratones jóvenes sobre parámetros de envejecimiento y fragilidad en ratones de edad avanzada
Entidad Financiadora: Ministerio de Ciencia e Innovación
Investigador principal: Consuelo Borrás Blasco
Duración: 2021 – 2024
Presupuesto: 181.500 €
Referencia: GV/2018/067
Título: Estudio de posibles huellas genéticas de envejecimiento saludable en descendientes de centenarios
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Marta Inglés de la Torre
Duración: 2018 – 2019
Presupuesto: 12.040 €
Referencia: PCIN-2017-117
Título: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Consuelo Borrás Blasco
Duración: 2017 – 2022
Presupuesto: 143.000 €
Referencia: INTIMIC-085
Título: GUTMOM: Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention
Entidad Financiadora: European Commission. JPI HDHL
Investigador principal: Patricia Lozzo
Duración: 2017 – 2020
Presupuesto: 778.240 €
Referencia: COST Action CA15203 MITOEAGLE
Título: Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Entidad Financiadora: European Commission
Investigador principal: Erich Gnaiger
Duración: 2016 – 2020
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Título: Muscle architecture determined by ultrasound for the diagnosis of frailty with correlation of clinical, physical and biochemical markers
Doctorando: Vucetic, Jelena
Director: Borrás Blasco, Consuelo; Mirón Mombiela, Rebeca; Marcaida Benito, Goizane
Fecha: 18/05/2023
Universidad: Universidad de Valencia

Título: Study of the role of BCL-XL in healthy aging and frailty prevention
Doctorando: Román Domínguez, Aurora
Director: Borrás Blasco, Consuelo; Mas Bargues, Cristina; Viña Ribes, José
Fecha: 03/03/2023
Universidad: Universitat de València

Título: Efecto favorable de la comunicación intercelular a través de vesículas extracelulares derivadas de células madre del tejido adiposo en el envejecimiento.
Doctorando: Sanz Ros, Jorge Manuel
Director: Borrás Blasco, Consuelo; Viña Ribes, Jose; Mas Bargues, Cristina
Fecha: 16/09/2022
Universidad: Univeridad de Valencia

Título: Estudio comparativo de los efectos del ejercicio físico de baja intensidad, de la estimulación magnética transcraneal y de la terapia con oxígeno hiperbárico en mujeres con fibromialgia. Ensayo clínico aleatorizado
Doctorando: Izquierdo Alventosa, Ruth
Director: Inglés de la Torre, Marta; Serra Añó, Pilar; Cortés Amador, Sara
Fecha: 14/01/2022
Universidad: Univeridad de Valencia

Título: Transcriptómica en centenarios: un ejemplo de envejecimiento satisfactorio
Doctorando: Dromant Jarque, Mar
Director: Inglés De La Torre, Marta; Borrás Blasco, Consuelo; Viña Ribes, José
Fecha: 21/12/2021
Universidad: Universitat de València

Título: Eficacia de la terapia manual en pacientes con migraña
Doctorando: Muñoz Gómez, Elena
Director: Inglés De La Torre, Marta; Espí López, Gemma Victoria
Fecha: 23/04/2021
Universidad: Universitat de València

Título: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctorando: Muñoz Cebriá, José Enrique
Director: Viña, José; Borrás, Consuelo; Gambini, Juan
Fecha: 01/07/2020
Universidad: Universitat de València

Título: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctorando: Mirón Mombiela, Rebeca
Director: Borrás Blasco, Consuelo; Forner Giner, Juana
Fecha: 28/01/2019
Universidad: Universitat de València