Grupo de Investigación en Anestesiología y Reanimación

Área de Metabolismo y Daño Orgánico

Abordaje de pulmón abierto para manejo respiratorio

Manejo del dolor crónico

Análisis de desempeño de ventiladores domiciliarios y de UCI (modelo de banco)

Manejo respiratorio en pacientes con SDRA COVID19

Donación controlada después de la determinación circulatoria de muerte con el uso de normotermia regional perfusión

Determinación de muerte por criterios neurológicos

Prevalencia y factores de riesgo de delirio

Neuromonitorización avanzada en cuidados neurocríticos

COVID 19 (SARS-CoV-2) Manejo en UCI

Coordinador
Dr. Carlos Tornero Tornero
carlos.tornero@uv.es; tornero_cartor@gva.es

INVESTIGADORES
R4 Senior

Carlos Tornero Tornero    

R3 Consolidado

Armando Maruenda Paulino
Gerardo Aguilar Aguilar
Marina Soro Domingo
Rafael Badenes Quiles

R2 Novel / Emergente

Ana Mugarra Llopis
Andrea Gutiérrez Valcárcel
Benigno Escamilla Cañete
Jorge Orduña Valls
Mª Luisa García Pérez
Mar Garzando Civera
Rosa Herrera Castro

R1 Predoctoral

Blanca Arocas Chicote

STAFF
Colaborador/a

Antonio Guillen Bañuelos
Cristina Crisán Ovidiu
Ernesto Pastor Martínez
Estefania Gracia Ferrándiz
Jose Antonio Carbonell López
Laura Reviriego Agudo
Liliana Patricia Henao Guerrero
Luis Robert Sánchez
Mª José Parra González
Mª Luisa Laredo Alcázar
Mario De Fez Barberá
Paola Valls Montero

Enfermero/a

Alicia García Vigara

Técnico/a
Apoyo
Publicaciones
Changes in sub-endocardial viability ratio in traumatic brain injury patients. Siwicka-Gieroba D, Robba C, Poleszczuk J, Debowska M, Waniewski J, Badenes R, Jaroszynski A, Piasek E, Kotfis K, Biernawska J, Dabrowski W. Brain Connectivity. 2021 Feb 9. doi: 10.1089/brain.2020.0850. PMID: 33559521

Disease Burden and Costs in Moderate-to-Severe Chronic Osteoarthritis Pain Refractory to Standard of Care: Ancillary Analysis of the OPIOIDS Real-World Study. Sicras-Mainar A, Rejas-Gutierrez J, Vargas-Negrin F, Tornero-Tornero J, Sicras-Navarro A, Lizarraga I. Rheumatology And Therapy. 2021 Jan 7. doi: 10.1007/s40744-020-00271-y. PMID: 33411324

Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion. Padilla M, Coll E, Fernandez-Perez C, Pont T, Ruiz A, Perez-Redondo M, Oliver E, Atutxa L, Mancino JM, Daga D, Minambres E, Moya J, Vidal B, Duenas-Jurado JM, Mosteiro F, Rodriguez-Salgado A, Fernandez-Garcia E, Lara R, Hernandez-Marrero D, Estebanez B, Rodriguez-Ferrero ML, Barber M, Garcia-Lopez F, Andres A, Santiago C, Zapatero A, Badenes R, Carrizosa F, Blanco JJ, Bernal JL, Elola FJ, Vidal C, Terron C, Castro P, Comas J, Dominguez-Gil B. American Journal of Transplantation. 2021 Apr 23. doi: 10.1111/ajt.16622. PMID: 33891793

Ketamine in acute phase of severe traumatic brain injury an old drug for new uses?. Godoy D, Badenes R, Pelosi P, Robba C. Critical Care. 2021 Jan 6;25(1):19. doi: 10.1186/s13054-020-03452-x. PMID: 33407737

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Pun B, Badenes R, Heras La Calle G, Orun O, Chen W, Raman R, Simpson B, Wilson-Linville S, Hinojal Olmedillo B, Vallejo de la Cueva A, van der Jagt M, Navarro Casado R, Leal Sanz P, Orhun G, Ferrer Gomez C, Nunez Vazquez K, Pineiro Otero P, Taccone F, Gallego Curto E, Caricato A, Woien H, Lacave G, O’Neal H, Peterson S, Brummel N, Girard T, Ely E, Pandharipande P, COVID-19 Intensive Care International Study Group. The Lancet. Respiratory medicine. 2021 Jan 8;S2213-2600(20)30552-X. doi: 10.1016/S2213-2600(20)30552-X. PMID: 33428871

The effects of arterial CO 2 on the injured brain: two faces of the same coin. Godoy D, Rovegno M, Lazaridis C, Badenes Quiles R. Journal of Critical Care. 2021 Feb;61:207-215. doi: 10.1016/j.jcrc.2020.10.028. PMID: 33186827

The role of non-invasive brain oximetry in adult critically ill patients without primary brain injury. Badenes R, Bogossian EG, Chisbert V, Robba C, Oddo M, Taccone FS, Matta BF. Minerva Anestesiologica. 2021 May 3. doi: 10.23736/S0375-9393.21.15333-7. PMID: 33938677

What Ingredients are Essential for the Recipe of a Study?. Castro R. Journal of Investigative Surgery. 2021 Jan;34(1):89-90. doi: 10.1080/08941939.2019.1587114. PMID: 31514553

A noninvasive postoperative clinical score to identify patients at risk for postoperative pulmonary complications: the Air-Test Score. Ferrando C, Suárez-Sipmann F, Librero J, Pozo De La Rosa N, Soro Domingo M, Unzueta C, Brunelli A, Peiró S, Llombart A, Balust J, Aldecoa C, Díaz-Cambronero O, Franco T, Redondo F, Garutti I, García J, Ibáñez M, Granell M, Rodríguez A, Gallego L, de la Matta M, Marcos J, García J, Mazzinari G, Tusman G, Villar J, Belda Nacher F, Individualized PeRioperative Openlung VEntilation (iPROVE) Network. Minerva Anestesiologica. 2020 Apr;86(4):404-415. doi: 10.23736/S0375-9393.19.13932-6. PMID: 31808662

A prospective, randomized, controlled study assessing vagus nerve stimulation using the gammaCore-Sapphire device for patients with moderate to severe CoViD-19 Respiratory Symptoms (SAVIOR): A structured summary of a study protocol for a randomised controlled trial». Tornero Tornero C, Vallejo R, Cedeno D, Orduña Valls J, Pastor Martinez E, Belaouchi M, Escamilla Cañete B, Laredo Alcazar M, Garzando Civera M. Trials. 2020 Jun 26;21(1):576. doi: 10.1186/s13063-020-04486-w. PMID: 32586395

Arterial and Venous Cerebral Blood Flow Velocities and Their Correlation in Healthy Volunteers and Traumatic Brain Injury Patients. Cardim D, Czosnyka M, Chandrapatham K, Badenes Quiles R, Bertuccio A, Corradi F, Donnelly J, Pelosi P, Hutchinson P, Robba C. Journal of Neurosurgical Anesthesiology. 2020 Jun 16. doi: 10.1097/ANA.0000000000000704. PMID: 32555064

Blind intubation through the disposable intubating laryngeal tube suction: A prospective observational study. Reviriego Agudo L, Charco Mora P, Greif R, Kleine-Brueggeney M. European Journal of Anaesthesiology. 2020 Jun;37(6):508-510. doi: 10.1097/EJA.0000000000001213. PMID: 32379150

Brain Ultrasonography Consensus on Skill Recommendations and Competence Levels Within the Critical Care Setting. Robba C, Poole D, Citerio G, Taccone F, Rasulo F, Badenes Quiles R, Consensus on brain ultrasonography in critical care group. Neurocritical Care. 2020 Apr;32(2):502-511. doi: 10.1007/s12028-019-00766-9. PMID: 31264072

Cerebrospinal fluid glucose and lactate levels after subarachnoid hemorrhage: a multicenter retrospective study. Taccone F, Badenes Quiles R, Arib S, Rubulotta F, Mirek S, Franchi F, Gordon S, Nadji A, Crippa I, Stazi E, Bouhemad B, Lozano Roig A, Creteur J, Bilotta F. Journal of Neurosurgical Anesthesiology. 2020 Apr;32(2):170-176. doi: 10.1097/ANA.0000000000000584. PMID: 31116707

Chronic pregabalin treatment ameliorates pain, but not depressive-like behaviors, in a reserpine-induced myalgia model in rats. Gonzalez-Soler E, Blasco-Serra A, Alfosea-Cuadrado G, Igual-Lopez M, Orduña Valls J, Tornero Tornero C, Valverde-Navarro A. Pain Physician. 2020 Nov;23(6):E581-E590. PMID: 33185377

Could lung bacterial dysbiosis predict ICU mortality in patients with extra-pulmonary sepsis? A proof-of-concept study. Sepsis Lung Microbiome Study Group. Intensive Care Medicine. 2020 Nov;46(11):2118-2120. doi: 10.1007/s00134-020-06190-4. PMID: 32767076

Decompressive craniectomy improves qtc interval in traumatic brain injury patients. Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes Quiles R, Kotfis K, Schlegel T, Jaroszynski A. International Journal of Environmental Research and Public Health. 2020 Nov 21;17(22):8653. doi: 10.3390/ijerph17228653. PMID: 33233364

Delays in hospital admissions in patients with fractures across 18 low-income and middle-income countries (INORMUS): a prospective observational study. Pouramin P, Li C, Busse J, Sprague S, Devereaux P, Jagnoor J, Ivers R, Bhandari M, Aguilar Aguilar G, INORMUS Investigators. Lancet Global Health. 2020 May;8(5):e711-e720. doi: 10.1016/S2214-109X(20)30067-X. PMID: 32353318

Determination of brain death/death by neurologic criteria: The World Brain Death Project. Greer D, Shemie S, Lewis A, Torrance S, Varelas P, Goldenberg F, Bernat J, Souter M, Topcuoglu M, Alexandrov A, Baldisseri M, Bleck T, Citerio G, Dawson R, Hoppe A, Jacobe S, Manara A, Nakagawa T, Pope T, Silvester W, Thomson D, Al Rahma H, Badenes Quiles R, Baker A, Cerny V, Chang C, Chang T, Gnedovskaya E, Han M, Honeybul S, Jimenez E, Kuroda Y, Liu G, Mallick U, Marquevich V, Mejia-Mantilla J, Piradov M, Quayyum S, Shrestha G, Su Y, Timmons S, Teitelbaum J, Videtta W, Zirpe K, Sung G. JAMA-Journal of the American Medical Association. 2020 Sep 15;324(11):1078-1097. doi: 10.1001/jama.2020.11586. PMID: 32761206

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Villar J, Ferrando C, Martinez D, Ambros A, Munoz T, Soler J, Aguilar Aguilar G, Alba F, Gonzalez-Higueras E, Conesa L, Martin-Rodriguez C, Diaz-Dominguez F, Serna-Grande P, Rivas R, Ferreres Franco J, Belda Nacher F, Capilla L, Tallet A, Anon J, Fernandez R, Gonzalez-Martin J, Dexamethasone ARDS Network. Lancet Respiratory Medicine. 2020 Mar;8(3):267-276. doi: 10.1016/S2213-2600(19)30417-5. PMID: 32043986

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Early Osmotherapy in Severe Traumatic Brain Injury: An International Multicenter Study. Anstey J, Taccone F, Udy A, Citerio G, Duranteau J, Ichai C, Badenes Quiles R, Prowle J, Ercole A, Oddo M, Schneider A, van der Jagt M, Wolf S, Helbok R, Nelson D, Skrifvars M, Harrois A, Presneill J, Cooper D, Bailey M, Bellomo R, TBI Collaborative. Journal of Neurotrauma. 2020 Jan 1;37(1):178-184. doi: 10.1089/neu.2019.6399. PMID: 31286839

Effects of age and sex on optic nerve sheath diameter in healthy volunteers and patients with traumatic brain injury. Cardim D, Czosnyka M, Chandrapatham K, Badenes Quiles R, Bertuccio A, Di Noto A, Donnelly J, Pelosi P, Ball L, Hutchinson P, Robba C. Frontiers in Neurology. 2020 Aug 7;11:764. doi: 10.3389/fneur.2020.00764. PMID: 32849220

Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial. Ferrando C, Aldecoa C, Unzueta C, et al. British Journal of Anaesthesia. 2020 Jan;124(1):110-120. doi: 10.1016/j.bja.2019.10.009. PMID: 31767144

Efficacy of dexamethasone treatment for patients with the acute respiratory distress syndrome caused by COVID-19: study protocol for a randomized controlled superiority trial. Villar J, Añón J, Ferrando C, Aguilar G, Muñoz T, Ferreres J, Ambrós A, Aldecoa C, Suárez-Sipmann F, Thorpe K, Jüni P, Slutsky A, DEXA-COVID19 Network. Trials. 2020 Aug 16;21(1):717. doi: 10.1186/s13063-020-04643-1. PMID: 32799933

Extubation strategies in neuro-intensive care unit patients and associations with outcomes: the ENIO multicentre international observational study. Cinotti R, Pelosi P, Schultz M, Aikaterini I, Alvarez P, Badenes Quiles R, Mc Credie V, Elbuzidi A, Elhadi M, Agustin Godoy D, Gurjar M, Haenggi M, Kaye C, Cesar Mijangos-Mendez J, Piagnerelli M, Piracchio R, Reza S, Stevens R, Yoshitoyo U, Asehnoune K, ENIO Study Grp. Annals of Translational Medicine. 2020 Apr;8(7):503. doi: 10.21037/atm.2020.03.160. PMID: 32395547

Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2. Venkatasubba Rao CP, Suarez JI, Martin RH, Bauza C, Georgiadis A, Calvillo E, Claude Hemphill J, Sung G, Oddo M, Silvio Taccone F, LeRoux PD, PRINCE Study Investigators. Neurocritical Care. 2020 Feb;32(1):88-103. doi: 10.1007/s12028-019-00835-z. PMID: 31486027

Glucose and Lactate Concentrations in Cerebrospinal Fluid After Traumatic Brain Injury. Lozano A, Franchi F, Seastres R, Oddo M, Lheureux O, Badenes Quiles R, Scolletta S, Vincent J, Creteur J, Taccone F. Journal of Neurosurgical Anesthesiology. 2020 Apr;32(2):162-169. doi: 10.1097/ANA.0000000000000582. PMID: 30893283

Health outcomes and costs in patients with osteoarthritis and chronic pain treated with opioids in Spain: the OPIOIDS real-world study. Sicras Mainar A, Tornero Tornero C, Vargas Negrin F, Lizarraga I, Rejas Gutierrez J. Therapeutic Advances in Musculoskeletal Disease. 2020 Sep 17;12:1759720X20942000. doi: 10.1177/1759720X20942000. PMID: 32994809

Hemodynamic Monitoring in Patients With Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis. Simonassi F, Ball L, Badenes Quiles R, Millone M, Citerio G, Zona G, Pelosi P, Robba C. Journal of Neurosurgical Anesthesiology. 2020 Jan 31. doi: 10.1097/ANA.0000000000000679. PMID: 32011413

Hyperosmolar therapy for acute brain injury: study protocol for an umbrella review of meta-analyses and an evidence mapping. Badenes Quiles R, Hutton B, Citerio G, Robba C, Aguilar Aguilar G, Alonso-Arroyo A, Taccone F, Tornero Tornero C, Catala Lopez F. BMJ Open. 2020 Feb 6;10(2):e033913. doi: 10.1136/bmjopen-2019-033913. PMID: 32034026

International consensus on the monitoring of cerebral oxygen tissue pressure in neurocritical patients. Dominguez-Roldan JM, Lubillo S, Videtta W, Antonio Llompart-Pou J, Badenes Quiles R, Marquez Rivas J, Ibanez J, Godoy D, Murillo-Cabezas F, Gomez-Abascal L, Paranhos J, Recalde R, Miguel Montes J, Grp Expertos Monitorizacion Pacientes. Neurocirugia. 2020;31(1):24-36. doi: 10.1016/j.neucir.2019.08.003. PMID: 31708419

Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study. Robba C, Hemmes S, Neto A, Bluth T, Canet J, Hiesmayr M, Hollmann M, Mills G, Melo M, Putensen C, Jaber S, Schmid W, Severgnini P, Wrigge H, Battaglini D, Ball L, de Abreu M, Schultz M, Pelosi P, FERS LAS VEGAS Investigators, Soro Domingo M, European Soc Anaesthesiology. BMC Anesthesiology. 2020 Apr 2;20(1):73. doi: 10.1186/s12871-020-00988-x. PMID: 32241266

Limb Ischemic Conditioning Induces Oxidative Stress Followed by a Correlated Increase of HIF-1alpha in Healthy Volunteers. Garcia De La Asuncion J, Perez Griera J, Moreno Sanchez T, Duca A, Garcia Del Olmo E, Belda Nacher F, Soro Domingo M. Annals of Vascular Surgery. 2020 Jan;62:412-419. doi: 10.1016/j.avsg.2019.06.033. PMID: 31449936

Lung injury is a predictor of cerebral hypoxia and mortality in traumatic brain injury. Robba C, Asgari S, Gupta A, Badenes Quiles R, Sekhon M, Bequiri E, Hutchinson P, Pelosi P, Gupta A. Frontiers in Neurology. 2020 Aug 7;11:771. doi: 10.3389/fneur.2020.00771. PMID: 32849225

Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial. Kacmarek R, Villar J, Parrilla D, Alba F, Solano R, Liu S, Montiel R, Rico-Feijoo J, Vidal A, Ferrando C, Murcia I, Corpas R, Gonzalez-Higueras E, Sun Q, Pinedo C, Pestana D, Martinez D, Aldecoa C, Anon J, Soro Domingo M, Gonzalez-Martin J, Fernandez C, Fernandez R. Intensive Care Medicine. 2020 Dec;46(12):2327-2337. doi: 10.1007/s00134-020-06181-5. PMID: 32893313

Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: some nuances. Aguilar Aguilar G, Ferriols Lisart R, Martínez Castro S, Ezquer Garin C, Pastor Martinez E, Carbonell Lopez J, Alos Almiñana M, Navarro Ortega D. Critical Care. 2020 Jan 10;24(1):11. doi: 10.1186/s13054-019-2724-y. PMID: 31924240

Plasma Hyperosmolality Prolongs QTc Interval and Increases Risk for Atrial Fibrillation in Traumatic Brain Injury Patients. Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes Quiles R, Bialy M, Iwaniuk P, Schlegel T, Jaroszynski A. Journal of Clinical Medicine. 2020 Apr 30;9(5):1293. doi: 10.3390/jcm9051293. PMID: 32365845

Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial. PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) Group Collaborators. Anesthesia and Analgesia. 2020 Oct;131(4):1012-1024. doi: 10.1213/ANE.0000000000004788. PMID: 32304460

Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study. Ibarz M, Boumendil A, Haas L, Irazabal M, Flaatten H, de Lange D, Morandi A, Andersen F, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjolner J, Jung C, Marsh B, Moreno R, Oeyen S, Ohman C, Bollen Pinto B, Soliman I, Szczeklik W, Valentin A, Watson X, Zaferidis T, Guidet B, Artigas A, Aguilar Aguilar G, VIP1 study. Annals of Intensive Care. 2020 May 13;10(1):56. doi: 10.1186/s13613-020-00672-w. PMID: 32406016

The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database. Vincent J, Ferguson A, Pickkers P, Jakob S, Jaschinski U, Almekhlafi G, Leone M, Mokhtari M, Fontes L, Bauer P, Sakr Y, Aguilar Aguilar G, ICON Investigators. Critical Care. 2020 Apr 23;24(1):171. doi: 10.1186/s13054-020-02858-x. PMID: 32326981.

The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Guidet B, de Lange D, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F, Zafeiridis T, Jung C, Moreno R, Walther S, Oeyen S, Schefold J, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjolner J, Flaatten H, Aguilar Aguilar G, VIP2 Study Grp. Intensive Care Medicine. 2020 Jan;46(1):57-69. doi: 10.1007/s00134-019-05853-1. PMID: 31784798

Update of the treatment of nosocomial pneumonia in the ICU. Zaragoza R, Vidal-Cortes P, AGUILAR AGUILAR G, Borges M, Diaz E, Ferrer R, Maseda E, Nieto M, Nuvials F, Ramirez P, Rodriguez A, Soriano C, Veganzones J, Martin-Loeches I. Critical Care. 2020 Jun 29;24(1):383. doi: 10.1186/s13054-020-03091-2. PMID: 32600375

Variability in serum sodium concentration and prognostic significance in severe traumatic brain injury: a multicenter observational study. Harrois A, Anstey J, van der Jagt M, Taccone F, Udy A, Citerio G, Duranteau J, Ichai C, Badenes Quiles R, Prowle J, Ercole A, Oddo M, Schneider A, Wolf S, Helbok R, Nelson D, Cooper D, Bellomo R, TBI Collaborative. Neurocritical Care. 2020 Oct 2. doi: 10.1007/s12028-020-01118-8. PMID: 33009658

Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1. Suarez J, Martin R, Bauza C, Georgiadis A, Venkatasubba Rao C, Calvillo E, Hemphill J, Sung G, Oddo M, Taccone F, LeRoux P, Badenes Quiles R, PRINCE Study Investigators. Neurocritical Care. 2020 Feb;32(1):172-179. doi: 10.1007/s12028-019-00750-3. PMID: 31175567

A Prognostic Enrichment Strategy for Selection of Patients With Acute Respiratory Distress Syndrome in Clinical Trials. Villar J, Ambrós A, Mosteiro F, Martínez D, Fernández L, Ferrando C, Carriedo D, Soler JA, Parrilla D, Hernández M, Andaluz-Ojeda D, Añón JM, Vidal A, González-Higueras E, Martín-Rodríguez C, Díaz-Lamas AM, Blanco J, Belda J, Díaz-Domínguez FJ, Rico-Feijoó J, Martín-Delgado C, Romera MA, González-Martín JM, Fernández RL, Kacmarek RM; Spanish Initiative for Epidemiology, Stratification and Therapies of ARDS (SIESTA) Network. Critical Care Medicine. 2019 Mar;47(3):377-385. doi: 10.1097/CCM.0000000000003624. PMID: 30624279

Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications. Cortegiani A, Gregoretti C, Neto AS, Hemmes SNT, Ball L, Canet J, Hiesmayr M, Hollmann MW, Mills GH, Melo MFV, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Schultz MJ, Pelosi P; LAS VEGAS Investigators, the PROVE Network, and the Clinical Trial Network of the European Society of Anaesthesiology. British Journal of Anaesthesia. 2019 Mar;122(3):361-369. doi: 10.1016/j.bja.2018.10.063. PMID: 30770054

Association Between Use of Enhanced Recovery After Surgery Protocol and Postoperative Complications in Colorectal Surgery: The Postoperative Outcomes Within Enhanced Recovery After Surgery Protocol (POWER) Study. Ripollés-Melchor J, Ramírez-Rodríguez JM, Casans-Francés R, Aldecoa C, Abad-Motos A, Logroño-Egea M, García-Erce JA, Camps-Cervantes Á, Ferrando-Ortolá C, Suarez de la Rica A, Cuellar-Martínez A, Marmaña-Mezquita S, Abad-Gurumeta A, Calvo-Vecino JM; POWER Study Investigators Group for the Spanish Perioperative Audit and Research Network (REDGERM). JAMA Surgery. 2019 Aug 1;154(8):725-736. doi: 10.1001/jamasurg.2019.0995. PMID: 31066889

Ceftolozane Pharmacokinetics in a Septic Critically Ill Patient under Different Extracorporeal Replacement Therapies. Carbonell N, Aguilar G, Ferriols R, Huerta R, Ferreres J, Calabuig M, Juan M, Ezquer C, Colomina J, Blasco ML. Antimicrobial agents and chemotherapy. 2019 Dec 20;64(1):e01782-19. doi: 10.1128/AAC.01782-19. PMID: 31658972

Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research. Vande Vyvere T, Wilms G, Claes L, Martin Leon F, Nieboer D, Verheyden J, van den Hauwe L, Pullens P, Maas AIR, Parizel PM; Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants. Journal of Neurotrauma. 2019 Apr 1;36(7):1080-1092. doi: 10.1089/neu.2018.6061. PMID: 30259789

Cervical plexus as anatomical target for the treatment of postoperative cervical neuropathic pain. Orduña Valls JM, Soto E, Ferrandis Martínez M, Nebreda C, Tornero Tornero C. Journal of Pain Research. 2019 Apr 16;12:1217-1221. doi: 10.2147/JPR.S184306. PMID: 31114303

Development of a quality indicator set to measure and improve quality of ICU care for patients with traumatic brain injury. Huijben JA, Wiegers EJA, de Keizer NF, Maas AIR, Menon D, Ercole A, Citerio G, Lecky F, Wilson L, Cnossen MC, Polinder S, Steyerberg EW, van der Jagt M, Lingsma HF; Delphi panel. Critical Care. 2019 Mar 22;23(1):95. doi: 10.1186/s13054-019-2377-x. PMID: 30902117

Glia to neuron ratio in the posterior aspect of the human spinal cord at thoracic segments relevant to spinal cord stimulation. Ruiz Sauri A, Orduña Valls J, Blasco-Serra A, Tornero Tornero C, Cedeno D, Bejarano-Quisoboni D, Valverde-Navarro A, Benyamin R, Vallejo R. Journal of Anatomy. 2019 Nov;235(5):997-1006. doi: 10.1111/joa.13061. PMID: 31347695

High-flow nasal cannula oxygenation reduces postoperative hypoxemia in morbidly obese patients: a randomized controlled trial. Ferrando C1,2, Puig J3, Serralta F4, Carrizo J4, Pozo N4, Arocas B4, Gutierrez A4, Villar J5,6,7, Belda FJ4, Soro M4.. Minerva Anestesiologica. 2019 Oct;85(10):1062-1070. doi: 10.23736/S0375-9393.19.13364-0. PMID: 30994312

Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery. Edwards MR, Forbes G, MacDonald N, Berdunov V, Mihaylova B, Dias P, Thomson A, Grocott MP, Mythen MG, Gillies MA, Sander M, Phan TD, Evered L, Wijeysundera DN, McCluskey SA, Aldecoa C, Ripollés-Melchor J, Hofer CK, Abukhudair H, Szczeklik W, Grigoras I, Hajjar LA, Kahan BC, Pearse RM; OPTIMISE II investigators. BMJ Open. 2019 Jan 15;9(1):e023455. doi: 10.1136/bmjopen-2018-023455. PMID: 30647034

Optimizing ceftolozane-tazobactam dosage in critically ill patients during continuous venovenous hemodiafiltration. Aguilar G, Ferriols R, Martínez-Castro S, Ezquer C, Pastor E, Carbonell JA, Alós M, Navarro D. Critical Care. 2019 Apr 26;23(1):145. doi: 10.1186/s13054-019-2434-5. PMID: 31027499

Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study. Kirmeier E, Eriksson LI, Lewald H, Jonsson Fagerlund M, Hoeft A, Hollmann M, Meistelman C, Hunter JM, Ulm K, Blobner M; POPULAR Contributors. Lancet Respiratory Medicine. 2019 Feb;7(2):129-140. doi: 10.1016/S2213-2600(18)30294-7. PMID: 30224322

Preoperative predictive model for acute kidney injury after elective cardiac surgery: a prospective multicenter cohort study. Callejas R, Panadero A, Vives M, Duque P, Echarri G, Monedero P; Renal Dysfunction in Cardiac Surgery Spanish Group (GEDRCC2).Minerva Anestesiologica. 2019 Jan;85(1):34-44. doi: 10.23736/S0375-9393.18.12257-7. PMID: 29756690

Prospective observational cohort study on grading the severity of postoperative complications in global surgery research. International Surgical Outcomes Study (ISOS) group. British Journal of Surgery. 2019 Jan;106(2):e73-e80. doi: 10.1002/bjs.11025. PMID: 30620066

Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV). Carramiñana A, Ferrando C, Unzueta MC, Navarro R, Suárez-Sipmann F, Tusman G, Garutti I, Soro M, Pozo N, Librero J, Gallego L, Ramasco F, Rabanal JM, Rodriguez A, Sastre J, Martinez J, Coves S, García P, Aguirre-Puig P, Yepes J, Lluch A, López-Herrera D, Leal S, Vives M, Bellas S, Socorro T, Trespalacios R, Salazar CJ, Mugarra A, Cinnella G, Spadaro S, Futier E, Ferrer L, Cabrera M, Ribeiro H, Celestino C, Kucur E, Cervantes O, Morocho D, Delphy D, Ramos C, Villar J, Belda J; iPROVE-OLV Network. Journal of Cardiothoracic and Vascular Anesthesia. 2019 Sep;33(9):2492-2502. doi: 10.1053/j.jvca.2019.01.056. PMID: 30928294

Sevoflurane Well-Handled in Children Is Excellent, but in the Wrong Hands Can Be Life-Threatening. Herrera Castro R. Journal Of Investigative Surgery. 2019 Jun 4:1-2. doi: 10.1080/08941939.2019.1616860. PMID: 31164021

The quest for the perfect Weaning Index. Ferrando C, Mellado R, Belda FJ. Minerva Anestesiologica. 2019 Apr;85(4):336-337. doi: 10.23736/S0375-9393.19.13593-6. PMID: 30871309

Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study (vol 161, pg 453, 2019). van Essen TA, den Boogert HF, Cnossen MC, de Ruiter GCW, Haitsma I, Polinder S, Steyerberg EW, Menon D, Maas AIR, Lingsma HF, Peul WC; CENTER-TBI Investigators and Participants. Acta Neurochirurgica. 2019 Mar;161(3):451-455. doi: 10.1007/s00701-019-03815-6. PMID: 30715604

Proyectos
Referencia: SUBCOVERWD-19
Título: Severity Subgroup Discovery and Classification on COVID-19 Real World Data through Machine Learning and Data Quality assessment
Entidad Financiadora: CRUE-Banco Santander
Investigador principal: Rafael Badenes Quiles
Duración: 2020 – 2021
Presupuesto: 15.000 €

Referencia: COV20/00096
Título: Sedación con sevoflurano en pacientes con Síndrome de distrés respiratorio causado por la infección COVID19
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: Rafael Badenes Quiles
Duración: 2020 – 2021
Presupuesto: 21.500 €

+ Información
Título: Anatomía sensitiva de la rodilla. Anatomía e implicaciones clínicas
Doctorando: Orduña Valls, Jorge
Director: Álvarez Escudero, Julián; Quintáns Rodríguez, Maximino
Fecha: 21/02/2020
Universidad: Universidad de Santiago de Compostela

Título: Rendimiento de los ventiladores de turbina para cuidados críticos
Doctorando: Delgado Navarro, Carlos
Director: Belda Nácher, Francisco Javier; Puig Bernabeu, Jaume; Ferrando Ortolá, Carlos
Fecha: 07/06/2019
Universidad: Universitat de València

Título: Efectos de la maniobra de reclutamiento y ajuste de PEEP sobre la oxigenación y la mecánica pulmonar durante la ventilación pulmonar selectiva
Doctorando: Gutiérrez Valcárcel, Andrea
Director: Belda Nácher, Francisco Javier; Ferrando Ortolá, Carlos; Soro Domingo, Marina
Fecha: 06/11/2020
Universidad: Universitat de València