Grupo de Investigación en Anestesiología y Reanimación

Área de Metabolismo y Daño Orgánico

Abordaje de pulmón abierto para manejo respiratorio

Manejo del dolor crónico

Análisis de desempeño de ventiladores domiciliarios y de UCI (modelo de banco)

Manejo respiratorio en pacientes con SDRA COVID19

Donación controlada después de la determinación circulatoria de muerte con el uso de normotermia regional perfusión

Determinación de muerte por criterios neurológicos

Prevalencia y factores de riesgo de delirio

Neuromonitorización avanzada en cuidados neurocríticos

COVID 19 (SARS-CoV-2) Manejo en UCI

Coordinador
Dr. Carlos Tornero Tornero
carlos.tornero@uv.es; tornero_cartor@gva.es

INVESTIGADORES
R4 Senior

Carlos Tornero Tornero    

R3 Consolidado

Armando Maruenda Paulino
Gerardo Aguilar Aguilar
Marina Soro Domingo
Rafael Badenes Quiles

R2 Novel / Emergente

Ana Mugarra Llopis
Andrea Gutiérrez Valcárcel
Benigno Escamilla Cañete
Jorge Orduña Valls
Mª Luisa García Pérez
Mar Garzando Civera
Rosa Herrera Castro

R1 Predoctoral

Blanca Arocas Chicote

STAFF
Colaborador/a

Antonio Guillen Bañuelos
Cristina Crisán Ovidiu
Ernesto Pastor Martínez
Estefania Gracia Ferrándiz
Jose Antonio Carbonell López
Laura Reviriego Agudo
Liliana Patricia Henao Guerrero
Luis Robert Sánchez
Mª José Parra González
Mª Luisa Laredo Alcázar
Mario De Fez Barberá
Paola Valls Montero

Enfermero/a
Técnico/a
Apoyo

Nuria Bargues Martín

Publicaciones
Arterial and Venous Cerebral Blood Flow Velocities and Their Correlation in Healthy Volunteers and Traumatic Brain Injury Patients. Cardim D, Czosnyka M, Chandrapatham K, Badenes Quiles R, Bertuccio A, Corradi F, Donnelly J, Pelosi P, Hutchinson P, Robba C. Journal of Neurosurgical Anesthesiology. 2022 Jan 1;34(1):e24-e33. doi: 10.1097/ANA.0000000000000704. PMID: 32555064

Effects of remote ischemic postconditioning on HIF-1 alpha and other markers in on-pump cardiac surgery. Garcia-de-la-Asuncion J, Moreno T, Duca A, Garcia-del-Olmo N, Perez-Griera J, Belda J, Soro M, Garcia-del-Olmo E. General Thoracic and Cardiovascular Surgery. 2022 Mar;70(3):239-247. doi: 10.1007/s11748-021-01690-6. PMID: 34378159

Non-use of information and communication technology as a predictor of frailty in postmenopausal midlife and older women. Garcia-Vigara A, Cano A, Fernandez-Garrido J, Carbonell-Asins J, Tarin J, Sanchez-Sanchez M. Maturitas. 2022 Feb;156:60-64. doi: 10.1016/j.maturitas.2021.05.010. PMID: 34275701

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. COVIDSurg Collaborative, GlobalSurg Collaborative. Medical Journal of Australia. 2022 Jan;77(1):28-39. doi: 10.1111/anae.15563. PMID: 34428858

Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study. Rasulo F, Calza S, Robba C, Taccone F, Biasucci D, Badenes R, Piva S, Savo D, Citerio G, Dibu J, Curto F, Merciadri M, Gritti P, Fassini P, Park S, Lamperti M, Bouzat P, Malacarne P, Chieregato A, Bertuetti R, Aspide R, Cantoni A, McCredie V, Guadrini L, Latronico N. Critical Care. 2022 Apr 15;26(1):110. doi: 10.1186/s13054-022-03978-2. PMID: 35428353

Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial. Robba C, Nielsen N, Dankiewicz J, Badenes R, Battaglini D, Ball L, Brunetti I, Wendel Garcia P, Young P, Eastwood G, Chew MS, Jakobsen J, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Lilja G, Hammond NE, Saxena M, Martin A, Solar M, Taccone FS, Friberg HA, Pelosi P. BMJ Open 2022 Mar 3;12(3):e058001. doi: 10.1136/bmjopen-2021-058001. PMID: 35241476

Analgesic efficacy and safety of local infiltration following lumbar decompression surgery: a systematic review of randomized controlled trials. Tsaousi G, Tsitsopoulos PP, Pourzitaki C, Palaska E, Badenes R, Bilotta F. Journal of Clinical Medicine. 2021 Dec 17;10(24):5936. doi: 10.3390/jcm10245936. PMID: 34945233

Cerebral autoregulation in non-brain injured patients: a systematic review. Longhitano Y, Iannuzzi F, Bonatti G, Zanza C, Messina A, Godoy D, Dabrowski W, Li X, Czosnyka M, Pelosi P, Badenes R, Robba C. Frontiers in Neurology. 2021 Nov 16;12:732176. doi: 10.3389/fneur.2021.732176. PMID: 34899560

Changes in sub-endocardial viability ratio in traumatic brain injury patients. Siwicka-Gieroba D, Robba C, Poleszczuk J, Debowska M, Waniewski J, Badenes R, Jaroszynski A, Piasek E, Kotfis K, Biernawska J, Dabrowski W. Brain Connectivity. 2021 Jun;11(5):349-358. doi: 10.1089/brain.2020.0850. PMID: 33559521

Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS. Ferrando C, Suarez-Sipmann F, Mellado-Artigas R, Hernandez M, Gea A, Arruti E, Aldecoa C, Martinez-Palli G, Martinez-Gonzalez M, Slutsky A, Villar J, COVID-19 Spanish ICU Network. Intensive Care Medicine. 2021 Jan;47(1):144-146. doi: 10.1007/s00134-020-06251-8. PMID: 33263817

Disease Burden and Costs in Moderate-to-Severe Chronic Osteoarthritis Pain Refractory to Standard of Care: Ancillary Analysis of the OPIOIDS Real-World Study. Sicras-Mainar A, Rejas-Gutierrez J, Vargas-Negrin F, Tornero-Tornero J, Sicras-Navarro A, Lizarraga I. Rheumatology And Therapy. 2021 Mar;8(1):303-326. doi: 10.1007/s40744-020-00271-y. PMID: 33411324

Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study. Monedero P, Gea A, Castro P, Candela-Toha A, Hernandez-Sanz M, Arruti E, Villar J, Ferrando C, COVID-19 Spanish ICU Network. Critical Care. 2021 Jan 4;25(1):2. doi: 10.1186/s13054-020-03422-3. PMID: 33397463

Hemodynamic Monitoring in Patients With Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis. Simonassi F, Ball L, Badenes Quiles R, Millone M, Citerio G, Zona G, Pelosi P, Robba C. Journal of Neurosurgical Anesthesiology. 2021 Oct 1;33(4):285-292. doi: 10.1097/ANA.0000000000000679. PMID: 32011413

High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure. Mellado-Artigas R, Ferreyro B, Angriman F, Hernandez-Sanz M, Arruti E, Torres A, Villar J, Brochard L, Ferrando C, COVID-19 Spanish ICU Network. Critical Care. 2021 Feb 11;25(1):58. doi: 10.1186/s13054-021-03469-w. PMID: 33573680

Hyperventilation in severe traumatic brain injury has something changed in the last decade or uncertainty continues? A Brief Review. Godoy D, Badenes R, Robba C, Cabezas F. Frontiers in Neurology. 2021 Mar 11;12:573237. doi: 10.3389/fneur.2021.573237. PMID: 33776876

Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion. Padilla M, Coll E, Fernandez-Perez C, Pont T, Ruiz A, Perez-Redondo M, Oliver E, Atutxa L, Mancino JM, Daga D, Minambres E, Moya J, Vidal B, Duenas-Jurado JM, Mosteiro F, Rodriguez-Salgado A, Fernandez-Garcia E, Lara R, Hernandez-Marrero D, Estebanez B, Rodriguez-Ferrero ML, Barber M, Garcia-Lopez F, Andres A, Santiago C, Zapatero A, Badenes R, Carrizosa F, Blanco JJ, Bernal JL, Elola FJ, Vidal C, Terron C, Castro P, Comas J, Dominguez-Gil B. American Journal of Transplantation. 2021 Nov;21(11):3618-3628. doi: 10.1111/ajt.16622. PMID: 33891793

Inhaled anesthesia in neurosurgery: still a role?. Badenes R, Nato Consolato G, Pena JD, Bilotta F. Best Practice & Research-Clinical Anaesthesiology. 2021 Jul;35(2):231-240. doi: 10.1016/j.bpa.2020.10.004. PMID: 34030807

Institutional factors associated with adherence to enhanced recovery protocols for colorectal surgery: Secondary analysis of a multicenter study. Zorrilla-Vaca A, Stone A, Ripolles-Melchor J, Abad-Motos A, Ramirez-Rodriguez J, Galan-Menendez P, Mena G, Grant M, Spanish Perioperative Audit Res Ne, Spanish Perioperative Audit Res Ne, Spanish Perioperative Audit Res Ne. Journal of Clinical Anesthesia. 2021 Nov;74:110378. doi: 10.1016/j.jclinane.2021.110378. PMID: 34144497

Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study. Robba C, Graziano F, Rebora P, Elli F, Giussani C, Oddo M, Meyfroidt G, Helbok R, Taccone F, Prisco L, Vincent J, Suarez J, Stocchetti N, Citerio G, SYNAPSE-ICU Investigators. Lancet Neurology. 2021 Jul;20(7):548-558. doi: 10.1016/S1474-4422(21)00138-1. PMID: 34146513

Intranasal insulin administration to prevent delayed neurocognitive recovery and postoperative neurocognitive disorder: a narrative review. Badenes R, Qeva E, Giordano G, Romero-Garcia N, Bilotta F. International Journal of Environmental Research and Public Health. 2021 Mar 7;18(5):2681. doi: 10.3390/ijerph18052681. PMID: 33799976

Ketamine in acute phase of severe traumatic brain injury an old drug for new uses?. Godoy D, Badenes R, Pelosi P, Robba C. Critical Care. 2021 Jan 6;25(1):19. doi: 10.1186/s13054-020-03452-x. PMID: 33407737

Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol. Robba C, Citerio G, Taccone F, Galimberti S, Rebora P, Vargiolu A, Pelosi P, VENTIBRAIN Enlarged Steering Comm. BMJ Open. 2021 Aug 11;11(8):e047100. doi: 10.1136/bmjopen-2020-047100. PMID: 34380722

Neuromuscular blockade management and postoperative outcomes in enhanced recovery colorectal surgery: secondary analysis of POWER trial. Serrano A, Diaz-Cambronero O, Melchor-Ripolles J, Abad-Gurumeta A, Ramirez-Rodriguez J, Martinez-Ubieto J, Sanchez-Merchante M, Rodriguez R, Jorda L, Gil-Trujillo S, Cabellos-Olivares M, Bordonaba-Bosque D, Aldecoa C, POWER Grp, POWER Group, POWER Group. Minerva Anestesiologica. 2021 Jan;87(1):13-25. doi: 10.23736/S0375-9393.20.14589-9. PMID: 33538417

Outcome prognostication of acute brain injury using the neurological pupil index (ORANGE) study: protocol for a prospective, observational, multicentre, international cohort study. Oddo M, Taccone F, Galimberti S, Rebora P, Citerio G, Orange Study Group. BMJ Open. 2021 May 11;11(5):e046948. doi: 10.1136/bmjopen-2020-046948. PMID: 33980528

Perioperative management of polytrauma patients with severe traumatic brain injury undergoing emergency extracranial surgery: a narrative review. Picetti E, Rosenstein I, Balogh Z, Catena F, Taccone F, Fornaciari A, Votta D, Badenes R, Bilotta F. Journal of Clinical Medicine. 2021 Dec 21;11(1):18. doi: 10.3390/jcm11010018. PMID: 35011760

Potentially detrimental effects of hyperosmolality in patients treated for traumatic brain injury. Dabrowski W, Siwicka-Gieroba D, Robba C, Bielacz M, Solek-Pastuszka J, Kotfis K, Bohatyrewicz R, Jaroszynski A, Malbrain M, Badenes R. Journal of Clinical Medicine. 2021 Sep 14;10(18):4141. doi: 10.3390/jcm10184141. PMID: 34575255

Predictors of failure with high-flow nasal oxygen therapy in COVID-19 patients with acute respiratory failure: a multicenter observational study. Mellado-Artigas R, Mujica L, Ruiz M, Ferreyro B, Angriman F, Arruti E, Torres A, Barbeta E, Villar J, Ferrando C, COVID-19 Spanish ICU Network. Journal of Intensive Care. 2021 Mar 5;9(1):23. doi: 10.1186/s40560-021-00538-8. PMID: 33673863

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Pun B, Badenes R, Heras La Calle G, Orun O, Chen W, Raman R, Simpson B, Wilson-Linville S, Hinojal Olmedillo B, Vallejo de la Cueva A, van der Jagt M, Navarro Casado R, Leal Sanz P, Orhun G, Ferrer Gomez C, Nunez Vazquez K, Pineiro Otero P, Taccone F, Gallego Curto E, Caricato A, Woien H, Lacave G, O’Neal H, Peterson S, Brummel N, Girard T, Ely E, Pandharipande P, COVID-19 Intensive Care International Study Group. Lancet. Respiratory medicine. 2021; 9(3): 239-250. doi: 10.1016/S2213-2600(20)30552-X. PMID: 33428871

Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units. Wernly B, Beil M, Bruno R, Binnebossel S, Kelm M, Sigal S, van Heerden P, Boumendil A, Artigas A, Cecconi M, Marsh B, Moreno R, Oeyen S, Bollen Pinto B, Szczeklik W, Leaver S, Walther S, Schefold J, Joannidis M, Fjolner J, Zafeiridis T, de Lange D, Guidet B, Flaatten H, Jung C, VIP2 study group. BMJ Open. 2021 Jun 3;11(6):e046909. doi: 10.1136/bmjopen-2020-046909. PMID: 34083342

Recommendations for antibiotic selection for severe nosocomial infections. Mensa J, Barberan J, Ferrer R, Borges M, Rascado P, Maseda E, Oliver A, Marco F, Adalia R, Aguilar G, Estella A, Lopez R, Marcos M, de Molina F, Garcia R, Salavert M, Gomez J, Poliakova Y, Pasquau J, Azanza J, Arevalo G, Mondejar P, Cardinal-Fernandez P, Soriano A. Revista Española de Quimioterapia. 2021 Oct;34(5):511-524. doi: 10.37201/req/126.2021. PMID: 34693705

Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of the pandemic: observational report from 28 European intensive care units. Lavinio A, Ercole A, Battaglini D, Magnoni S, Badenes R, Taccone F, Helbok R, Thomas W, Pelosi P, Robba C. Critical Care. 2021 Apr 22;25(1):155. doi: 10.1186/s13054-021-03543-3. PMID: 33888132

Seizures and sepsis: a narrative review. Alessandri F, Badenes R, Bilotta F. Journal of Clinical Medicine. 2021 Mar 3;10(5):1041. doi: 10.3390/jcm10051041. PMID: 33802419

Sevoflurane Well-Handled in Children Is Excellent, but in the Wrong Hands Can Be Life-Threatening. Herrera Castro R. Journal Of Investigative Surgery. 2021 Feb;34(2):241-242. doi: 10.1080/08941939.2019.1616860. PMID: 31164021

Stratification for Identification of Prognostic Categories In the Acute RESpiratory Distress Syndrome (SPIRES) Score. Villar J, Gonzalez-Martin JM, Ambros A, Mosteiro F, Martinez D, Fernandez L, Soler JA, Parra L, Solano R, Soro M, Del Campo R, Gonzalez-Luengo RI, Civantos B, Montiel R, Pita-Garcia L, Vidal A, Anon JM, Ferrando C, Diaz-Dominguez FJ, Mora-Ordonez JM, Fernandez MM, Fernandez C, Fernandez RL, Rodriguez-Suarez P, Steyerberg EW, Kacmarek RM. Critical Care Medicine. 2021 Oct 1;49(10):e920-e930. doi: 10.1097/CCM.0000000000005142. PMID: 34259448

Suppression of electrographic seizures is associated with amelioration of QTc interval prolongation in patients with traumatic brain injury. Dabrowski W, Siwicka-Gieroba D, Schlegel TT, Robba C, Zaid S, Bielacz M, Jaroszynski A, Badenes R. Journal of Clinical Medicine. 2021 Nov 18;10(22):5374. doi: 10.3390/jcm10225374. PMID: 34830656

Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts. Sakr Y, Francois B, Sole-Violan J, Kotfis K, Jaschinski U, Estella A, Leone M, Jakob S, Wittebole X, Fontes L, Gurgel M, Midega T, Vincent J, Ranieri V, SOAP ICON Investigators. Critical Care. 2021 Feb 25;25(1):87. doi: 10.1186/s13054-020-03455-8. PMID: 33632247

The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study. Mazzinari G, Neto A, Hemmes S, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann M, Mills G, Melo M, Pearse R, Putensen C, Schmid W, Severgnini P, Wrigge H, Cambronero O, Ball L, de Abreu M, Pelosi P, Schultz M, LAS VEGAS Study-Iinvestigators, PROtective VEntilation Network, European Soc Anaesthesiology. BMC Anesthesiology. 2021 Mar 19;21(1):84. doi: 10.1186/s12871-021-01268-y. PMID: 33740885

The effects of arterial CO 2 on the injured brain: two faces of the same coin. Godoy D, Rovegno M, Lazaridis C, Badenes Quiles R. Journal of Critical Care. 2021 Feb;61:207-215. doi: 10.1016/j.jcrc.2020.10.028. PMID: 33186827

The prone position must accommodate changes in IAP in traumatic brain injury patients. Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes R, Malbrain M. Critical Care. 2021 Apr 7;25(1):132. doi: 10.1186/s13054-021-03506-8. PMID: 33827641

The role of non-invasive brain oximetry in adult critically ill patients without primary brain injury. Badenes R, Bogossian EG, Chisbert V, Robba C, Oddo M, Taccone FS, Matta BF. Minerva Anestesiologica. 2021 Nov;87(11):1226-1238. doi: 10.23736/S0375-9393.21.15333-7. PMID: 33938677

The use of different components of brain oxygenation for the assessment of cerebral haemodynamics: a prospective observational study on COVID-19 patients. Robba C, Cardim D, Ball L, Battaglini D, Dabrowski W, Bassetti M, Giacobbe D, Czosnyka M, Badenes R, Pelosi P, Matta B. Frontiers in Neurology. 2021 Dec 20;12:735469. doi: 10.3389/fneur.2021.735469. PMID: 34987461

Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study. COVIDSurg Collaborative, GlobalSurg Collaborative. Anaesthesia. 2021 Jun;76(6):748-758. doi: 10.1111/anae.15458. PMID: 33690889

Usefulness of cerebral oximetry in TBI by NIRS. Barud M, Dabrowski W, Siwicka-Gieroba D, Robba C, Bielacz M, Badenes R. Journal of Clinical Medicine. 2021 Jun 30;10(13):2938. doi: 10.3390/jcm10132938. PMID: 34209017

Variability in serum sodium concentration and prognostic significance in severe traumatic brain injury: a multicenter observational study. Harrois A, Anstey J, van der Jagt M, Taccone F, Udy A, Citerio G, Duranteau J, Ichai C, Badenes Quiles R, Prowle J, Ercole A, Oddo M, Schneider A, Wolf S, Helbok R, Nelson D, Cooper D, Bellomo R, TBI Collaborative. Neurocritical Care. 2021 Jun;34(3):899-907. doi: 10.1007/s12028-020-01118-8. PMID: 33009658

What Ingredients are Essential for the Recipe of a Study?. Castro R. Journal of Investigative Surgery. 2021 Jan;34(1):89-90. doi: 10.1080/08941939.2019.1587114. PMID: 31514553

Whole-Blood mitochondrial DNA copies are associated with the prognosis of acute respiratory distress syndrome after sepsis. Hernandez-Beeftink T, Guillen-Guio B, Rodriguez-Perez H, Marcelino-Rodriguez I, Lorenzo-Salazar J, Corrales A, Prieto-Gonzalez M, Rodriguez-Perez A, Carriedo D, Blanco J, Ambros A, Gonzalez-Higueras E, Casanova N, Gonzalez-Garay M, Espinosa E, Muriel A, Dominguez D, de Lorenzo A, Anon J, Soro M, Belda J, Garcia J, Villar J, Flores C, Genetics Sepsis GEN-SEP Network. Frontiers in Immunology. 2021 Sep 7;12:737369. doi: 10.3389/fimmu.2021.737369. PMID: 34557198

A noninvasive postoperative clinical score to identify patients at risk for postoperative pulmonary complications: the Air-Test Score. Ferrando C, Suárez-Sipmann F, Librero J, Pozo De La Rosa N, Soro Domingo M, Unzueta C, Brunelli A, Peiró S, Llombart A, Balust J, Aldecoa C, Díaz-Cambronero O, Franco T, Redondo F, Garutti I, García J, Ibáñez M, Granell M, Rodríguez A, Gallego L, de la Matta M, Marcos J, García J, Mazzinari G, Tusman G, Villar J, Belda Nacher F, Individualized PeRioperative Openlung VEntilation (iPROVE) Network. Minerva Anestesiologica. 2020 Apr;86(4):404-415. doi: 10.23736/S0375-9393.19.13932-6. PMID: 31808662

A prospective, randomized, controlled study assessing vagus nerve stimulation using the gammaCore-Sapphire device for patients with moderate to severe CoViD-19 Respiratory Symptoms (SAVIOR): A structured summary of a study protocol for a randomised controlled trial». Tornero Tornero C, Vallejo R, Cedeno D, Orduña Valls J, Pastor Martinez E, Belaouchi M, Escamilla Cañete B, Laredo Alcazar M, Garzando Civera M. Trials. 2020 Jun 26;21(1):576. doi: 10.1186/s13063-020-04486-w. PMID: 32586395

Blind intubation through the disposable intubating laryngeal tube suction: A prospective observational study. Reviriego Agudo L, Charco Mora P, Greif R, Kleine-Brueggeney M. European Journal of Anaesthesiology. 2020 Jun;37(6):508-510. doi: 10.1097/EJA.0000000000001213. PMID: 32379150

Brain Ultrasonography Consensus on Skill Recommendations and Competence Levels Within the Critical Care Setting. Robba C, Poole D, Citerio G, Taccone F, Rasulo F, Badenes Quiles R, Consensus on brain ultrasonography in critical care group. Neurocritical Care. 2020 Apr;32(2):502-511. doi: 10.1007/s12028-019-00766-9. PMID: 31264072

Cerebrospinal fluid glucose and lactate levels after subarachnoid hemorrhage: a multicenter retrospective study. Taccone F, Badenes Quiles R, Arib S, Rubulotta F, Mirek S, Franchi F, Gordon S, Nadji A, Crippa I, Stazi E, Bouhemad B, Lozano Roig A, Creteur J, Bilotta F. Journal of Neurosurgical Anesthesiology. 2020 Apr;32(2):170-176. doi: 10.1097/ANA.0000000000000584. PMID: 31116707

Could lung bacterial dysbiosis predict ICU mortality in patients with extra-pulmonary sepsis? A proof-of-concept study. Sepsis Lung Microbiome Study Group. Intensive Care Medicine. 2020 Nov;46(11):2118-2120. doi: 10.1007/s00134-020-06190-4. PMID: 32767076

Decompressive craniectomy improves qtc interval in traumatic brain injury patients. Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes Quiles R, Kotfis K, Schlegel T, Jaroszynski A. International Journal of Environmental Research and Public Health. 2020 Nov 21;17(22):8653. doi: 10.3390/ijerph17228653. PMID: 33233364

Delays in hospital admissions in patients with fractures across 18 low-income and middle-income countries (INORMUS): a prospective observational study. Pouramin P, Li C, Busse J, Sprague S, Devereaux P, Jagnoor J, Ivers R, Bhandari M, Aguilar Aguilar G, INORMUS Investigators. Lancet Global Health. 2020 May;8(5):e711-e720. doi: 10.1016/S2214-109X(20)30067-X. PMID: 32353318

Determination of brain death/death by neurologic criteria: The World Brain Death Project. Greer D, Shemie S, Lewis A, Torrance S, Varelas P, Goldenberg F, Bernat J, Souter M, Topcuoglu M, Alexandrov A, Baldisseri M, Bleck T, Citerio G, Dawson R, Hoppe A, Jacobe S, Manara A, Nakagawa T, Pope T, Silvester W, Thomson D, Al Rahma H, Badenes Quiles R, Baker A, Cerny V, Chang C, Chang T, Gnedovskaya E, Han M, Honeybul S, Jimenez E, Kuroda Y, Liu G, Mallick U, Marquevich V, Mejia-Mantilla J, Piradov M, Quayyum S, Shrestha G, Su Y, Timmons S, Teitelbaum J, Videtta W, Zirpe K, Sung G. JAMA-Journal of the American Medical Association. 2020 Sep 15;324(11):1078-1097. doi: 10.1001/jama.2020.11586. PMID: 32761206

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Villar J, Ferrando C, Martinez D, Ambros A, Munoz T, Soler J, Aguilar Aguilar G, Alba F, Gonzalez-Higueras E, Conesa L, Martin-Rodriguez C, Diaz-Dominguez F, Serna-Grande P, Rivas R, Ferreres Franco J, Belda Nacher F, Capilla L, Tallet A, Anon J, Fernandez R, Gonzalez-Martin J, Dexamethasone ARDS Network. Lancet Respiratory Medicine. 2020 Mar;8(3):267-276. doi: 10.1016/S2213-2600(19)30417-5. PMID: 32043986

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Early Osmotherapy in Severe Traumatic Brain Injury: An International Multicenter Study. Anstey J, Taccone F, Udy A, Citerio G, Duranteau J, Ichai C, Badenes Quiles R, Prowle J, Ercole A, Oddo M, Schneider A, van der Jagt M, Wolf S, Helbok R, Nelson D, Skrifvars M, Harrois A, Presneill J, Cooper D, Bailey M, Bellomo R, TBI Collaborative. Journal of Neurotrauma. 2020 Jan 1;37(1):178-184. doi: 10.1089/neu.2019.6399. PMID: 31286839

Effects of age and sex on optic nerve sheath diameter in healthy volunteers and patients with traumatic brain injury. Cardim D, Czosnyka M, Chandrapatham K, Badenes Quiles R, Bertuccio A, Di Noto A, Donnelly J, Pelosi P, Ball L, Hutchinson P, Robba C. Frontiers in Neurology. 2020 Aug 7;11:764. doi: 10.3389/fneur.2020.00764. PMID: 32849220

Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial. Ferrando C, Aldecoa C, Unzueta C, et al. British Journal of Anaesthesia. 2020 Jan;124(1):110-120. doi: 10.1016/j.bja.2019.10.009. PMID: 31767144

Efficacy of dexamethasone treatment for patients with the acute respiratory distress syndrome caused by COVID-19: study protocol for a randomized controlled superiority trial. Villar J, Añón J, Ferrando C, Aguilar G, Muñoz T, Ferreres J, Ambrós A, Aldecoa C, Suárez-Sipmann F, Thorpe K, Jüni P, Slutsky A, DEXA-COVID19 Network. Trials. 2020 Aug 16;21(1):717. doi: 10.1186/s13063-020-04643-1. PMID: 32799933

Extubation strategies in neuro-intensive care unit patients and associations with outcomes: the ENIO multicentre international observational study. Cinotti R, Pelosi P, Schultz M, Aikaterini I, Alvarez P, Badenes Quiles R, Mc Credie V, Elbuzidi A, Elhadi M, Agustin Godoy D, Gurjar M, Haenggi M, Kaye C, Cesar Mijangos-Mendez J, Piagnerelli M, Piracchio R, Reza S, Stevens R, Yoshitoyo U, Asehnoune K, ENIO Study Grp. Annals of Translational Medicine. 2020 Apr;8(7):503. doi: 10.21037/atm.2020.03.160. PMID: 32395547

Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2. Venkatasubba Rao CP, Suarez JI, Martin RH, Bauza C, Georgiadis A, Calvillo E, Claude Hemphill J, Sung G, Oddo M, Silvio Taccone F, LeRoux PD, PRINCE Study Investigators. Neurocritical Care. 2020 Feb;32(1):88-103. doi: 10.1007/s12028-019-00835-z. PMID: 31486027

Glucose and Lactate Concentrations in Cerebrospinal Fluid After Traumatic Brain Injury. Lozano A, Franchi F, Seastres R, Oddo M, Lheureux O, Badenes Quiles R, Scolletta S, Vincent J, Creteur J, Taccone F. Journal of Neurosurgical Anesthesiology. 2020 Apr;32(2):162-169. doi: 10.1097/ANA.0000000000000582. PMID: 30893283

Health outcomes and costs in patients with osteoarthritis and chronic pain treated with opioids in Spain: the OPIOIDS real-world study. Sicras Mainar A, Tornero Tornero C, Vargas Negrin F, Lizarraga I, Rejas Gutierrez J. Therapeutic Advances in Musculoskeletal Disease. 2020 Sep 17;12:1759720X20942000. doi: 10.1177/1759720X20942000. PMID: 32994809

Hyperosmolar therapy for acute brain injury: study protocol for an umbrella review of meta-analyses and an evidence mapping. Badenes Quiles R, Hutton B, Citerio G, Robba C, Aguilar Aguilar G, Alonso-Arroyo A, Taccone F, Tornero Tornero C, Catala Lopez F. BMJ Open. 2020 Feb 6;10(2):e033913. doi: 10.1136/bmjopen-2019-033913. PMID: 32034026

International consensus on the monitoring of cerebral oxygen tissue pressure in neurocritical patients. Dominguez-Roldan JM, Lubillo S, Videtta W, Antonio Llompart-Pou J, Badenes Quiles R, Marquez Rivas J, Ibanez J, Godoy D, Murillo-Cabezas F, Gomez-Abascal L, Paranhos J, Recalde R, Miguel Montes J, Grp Expertos Monitorizacion Pacientes. Neurocirugia. 2020;31(1):24-36. doi: 10.1016/j.neucir.2019.08.003. PMID: 31708419

Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study. Robba C, Hemmes S, Neto A, Bluth T, Canet J, Hiesmayr M, Hollmann M, Mills G, Melo M, Putensen C, Jaber S, Schmid W, Severgnini P, Wrigge H, Battaglini D, Ball L, de Abreu M, Schultz M, Pelosi P, FERS LAS VEGAS Investigators, Soro Domingo M, European Soc Anaesthesiology. BMC Anesthesiology. 2020 Apr 2;20(1):73. doi: 10.1186/s12871-020-00988-x. PMID: 32241266

Limb Ischemic Conditioning Induces Oxidative Stress Followed by a Correlated Increase of HIF-1alpha in Healthy Volunteers. Garcia De La Asuncion J, Perez Griera J, Moreno Sanchez T, Duca A, Garcia Del Olmo E, Belda Nacher F, Soro Domingo M. Annals of Vascular Surgery. 2020 Jan;62:412-419. doi: 10.1016/j.avsg.2019.06.033. PMID: 31449936

Lung injury is a predictor of cerebral hypoxia and mortality in traumatic brain injury. Robba C, Asgari S, Gupta A, Badenes Quiles R, Sekhon M, Bequiri E, Hutchinson P, Pelosi P, Gupta A. Frontiers in Neurology. 2020 Aug 7;11:771. doi: 10.3389/fneur.2020.00771. PMID: 32849225

Microscopic Study of Injectable Steroids: Effects of Postmixing Time on Particle Aggregation. Orduna-Valls J, Cedeno D, Nebreda-Clavo C, Tornero-Tornero C, Alvarez-Escudero J, Ferrandis Martinez M, Valverde-Navarro A, Ruiz-Sauri A. Pain Physician. 2020 Jul;23(4):E417-E424. PMID: 32709188

Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial. Kacmarek R, Villar J, Parrilla D, Alba F, Solano R, Liu S, Montiel R, Rico-Feijoo J, Vidal A, Ferrando C, Murcia I, Corpas R, Gonzalez-Higueras E, Sun Q, Pinedo C, Pestana D, Martinez D, Aldecoa C, Anon J, Soro Domingo M, Gonzalez-Martin J, Fernandez C, Fernandez R. Intensive Care Medicine. 2020 Dec;46(12):2327-2337. doi: 10.1007/s00134-020-06181-5. PMID: 32893313

Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: some nuances. Aguilar Aguilar G, Ferriols Lisart R, Martínez Castro S, Ezquer Garin C, Pastor Martinez E, Carbonell Lopez J, Alos Almiñana M, Navarro Ortega D. Critical Care. 2020 Jan 10;24(1):11. doi: 10.1186/s13054-019-2724-y. PMID: 31924240

Plasma Hyperosmolality Prolongs QTc Interval and Increases Risk for Atrial Fibrillation in Traumatic Brain Injury Patients. Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes Quiles R, Bialy M, Iwaniuk P, Schlegel T, Jaroszynski A. Journal of Clinical Medicine. 2020 Apr 30;9(5):1293. doi: 10.3390/jcm9051293. PMID: 32365845

Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial. PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) Group Collaborators. Anesthesia and Analgesia. 2020 Oct;131(4):1012-1024. doi: 10.1213/ANE.0000000000004788. PMID: 32304460

Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study. Ibarz M, Boumendil A, Haas L, Irazabal M, Flaatten H, de Lange D, Morandi A, Andersen F, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjolner J, Jung C, Marsh B, Moreno R, Oeyen S, Ohman C, Bollen Pinto B, Soliman I, Szczeklik W, Valentin A, Watson X, Zaferidis T, Guidet B, Artigas A, Aguilar Aguilar G, VIP1 study. Annals of Intensive Care. 2020 May 13;10(1):56. doi: 10.1186/s13613-020-00672-w. PMID: 32406016

The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database. Vincent J, Ferguson A, Pickkers P, Jakob S, Jaschinski U, Almekhlafi G, Leone M, Mokhtari M, Fontes L, Bauer P, Sakr Y, Aguilar Aguilar G, ICON Investigators. Critical Care. 2020 Apr 23;24(1):171. doi: 10.1186/s13054-020-02858-x. PMID: 32326981.

The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Guidet B, de Lange D, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F, Zafeiridis T, Jung C, Moreno R, Walther S, Oeyen S, Schefold J, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjolner J, Flaatten H, Aguilar Aguilar G, VIP2 Study Grp. Intensive Care Medicine. 2020 Jan;46(1):57-69. doi: 10.1007/s00134-019-05853-1. PMID: 31784798

Update of the treatment of nosocomial pneumonia in the ICU. Zaragoza R, Vidal-Cortes P, AGUILAR AGUILAR G, Borges M, Diaz E, Ferrer R, Maseda E, Nieto M, Nuvials F, Ramirez P, Rodriguez A, Soriano C, Veganzones J, Martin-Loeches I. Critical Care. 2020 Jun 29;24(1):383. doi: 10.1186/s13054-020-03091-2. PMID: 32600375

Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1. Suarez J, Martin R, Bauza C, Georgiadis A, Venkatasubba Rao C, Calvillo E, Hemphill J, Sung G, Oddo M, Taccone F, LeRoux P, Badenes Quiles R, PRINCE Study Investigators. Neurocritical Care. 2020 Feb;32(1):172-179. doi: 10.1007/s12028-019-00750-3. PMID: 31175567

Proyectos
Referencia: SUBCOVERWD-19
Título: Severity Subgroup Discovery and Classification on COVID-19 Real World Data through Machine Learning and Data Quality assessment
Entidad Financiadora: CRUE-Banco Santander
Investigador principal: Rafael Badenes Quiles
Duración: 2020 – 2021
Presupuesto: 15.000 €

Referencia: COV20/00096
Título: Sedación con sevoflurano en pacientes con Síndrome de distrés respiratorio causado por la infección COVID19
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Rafael Badenes Quiles
Duración: 2020 – 2021
Presupuesto: 21.500 €

+ Información
Título: Rendimiento de los ventiladores de turbina para cuidados críticos
Doctorando: Delgado Navarro, Carlos
Director: Belda Nácher, Francisco Javier; Puig Bernabeu, Jaume; Ferrando Ortolá, Carlos
Fecha: 07/06/2019
Universidad: Universitat de València

Título: Anatomía sensitiva de la rodilla. Anatomía e implicaciones clínicas
Doctorando: Orduña Valls, Jorge
Director: Álvarez Escudero, Julián; Quintáns Rodríguez, Maximino
Fecha: 21/02/2020
Universidad: Universidad de Santiago de Compostela

Título: Efectos de la maniobra de reclutamiento y ajuste de PEEP sobre la oxigenación y la mecánica pulmonar durante la ventilación pulmonar selectiva
Doctorando: Gutiérrez Valcárcel, Andrea
Director: Belda Nácher, Francisco Javier; Ferrando Ortolá, Carlos; Soro Domingo, Marina
Fecha: 06/11/2020
Universidad: Universitat de València

Título: Cerebrospinal fluid glucose and lactate concentrations after traumatic brain injury
Doctorando: Lozano Roig, Angels
Director: Badenes Quiles, Rafael; Maruenda Paulino, Armando; Taccone, Fabio Silvio
Fecha: 30/06/2021
Universidad: Universitat de València

Título: Delirium en pacientes críticos con infección por SARS-CoV-2
Doctorando: Ferrer Gómez, Carolina
Director: Badenes Quiles, Rafael; De Andrés Ibáñez, José
Fecha: 19/11/2021
Universidad: Universitat de València