Grupo de Investigación en Células Madre aplicadas a la Reproducción; Viabilidad embrionaria y receptividad endometrial

Área de Medicina Reproductiva

Investigación en el campo de la Medicina Reproductiva, con especial énfasis en los campos de la medicina regenerativa relacionados con el endometrio y estudios genómicos sobre la viabilidad embrionaria y la receptividad endometrial, así como otros factores causantes de infertilidad

Avanzar en el conocimiento de los mecanismos que regulan la comunicación materno-fetal y que pueden estar involucrados en la implantación y posterior desarrollo de enfermedades del adulto como la obesidad y la diabetes tipo II

Creación de un modelo in vitro para la obtención de células germinales mediante reprogramación directa de células somáticas humanas, para proporcionar la solución definitiva para el tratamiento de la infertilidad

Coordinador
Carlos Simón Vallés
carlos.simon@uv.es

INVESTIGADORES
R4 Senior

Carlos Simón Vallés

R3 Consolidado

Carmen Rubio Lluesa
Inmaculada Moreno Gimeno

R2 Nobel / Emergente

Beatriz Rosón Burgo
Carlos Lozano Asencio
Carmen García Pascual
Antonio Díez Juan
Tamara Garrido Gómez
Mª Paz Moreno Murciano
Diana Valbuena Perilla
Nandakumar Venkatesan
Aymara Mas Perucho

R1 Predoctoral

Claudia Abellán Orihuela
Irene Muñoz Blat
Alba Machado López
Iolanda García Grau
Nerea Castillo Marco

STAFF
Colaborador/a

David Blesa Jarque

Enfermero/a
Técnico/a

Marta Gálvez Diezma
Marta González Monfort
Patricia Escorcia
Roberto Alonso Valero

Apoyo

Leslie Atkinson

Publicaciones
A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF. Simon Valles C, Gomez C, Cabanillas S, Vladimirov I, Castillon G, Giles Jimenez J, Boynukalin K, Findikli N, Bahceci M, Ortega I, Vidal C, Funabiki M, Izquierdo A, Lopez L, Portela S, Frantz N, Kulmann M, Taguchi S, Labarta E, Colucci F, Mackens S, Santamaria X, Munoz E, Barrera S, Garcia-Velasco J, Fernandez M, Ferrando M, Ruiz M, Mol B, Valbuena Parilla D, Era-Rct Study Consortium Group. Reproductive Biomedicine Online. 2020 Sep;41(3):402-415. doi: 10.1016/j.rbmo.2020.06.002. PMID: 32723696

Bacterial Vaginosis and Its Association with Infertility, Endometritis, and Pelvic Inflammatory Disease. Ravel J, Moreno Gimeno I, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Oct 19;S0002-9378(20)31193-5. doi: 10.1016/j.ajog.2020.10.019. PMID: 33091407

beta-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation. Danek P, Kardosova M, Janeckova L, Karkoulia E, Vanickova K, Fabisik M, Lozano-Asencio C, Benoukraf T, Tirado-Magallanes R, Zhou Q, Burocziova M, Rahmatova S, Pytlik R, Brdicka T, Tenen D, Korinek V, Alberich-Jorda M. Blood. 2020 Nov 26;136(22):2574-2587. doi: 10.1182/blood.2019004664. PMID: 32822472

Characteristics of the IVF Cycle that Contribute to the Incidence of Mosaicism. Rodrigo L, Clemente-Ciscar M, Campos-Galindo I, Peinado V, Simon Valles C, Rubio Lluesa C. Genes. 2020 Sep 30;11(10):1151. doi: 10.3390/genes11101151. PMID: 33007801

Combined Preimplantation Genetic Testing for Autosomal Dominant Polycystic Kidney Disease: Consequences for Embryos Available for Transfer. Mir Pardo P, Martinez-Conejero J, Martin J, Simon Valles C, Cervero A. Genes. 2020 Jun 24;11(6):692. doi: 10.3390/genes11060692. PMID: 32599795

Decidualization resistance in the origin of preeclampsia. Garrido Gomez T, Castillo Marco N, Cordero T, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Sep 29;S0002-9378(20)31130-3. doi: 10.1016/j.ajog.2020.09.039. PMID: 33007270

Endometrial Decidualization: The Primary Driver of Pregnancy Health. Ng S, Norwitz G, Pavlicev M, Tilburgs T, Simon Valles C, Norwitz E. International Journal of Molecular Sciences. 2020 Jun 8;21(11):4092. doi: 10.3390/ijms21114092. PMID: 32521725

Endometrial liquid biopsy provides a miRNA roadmap of the secretory phase of the human endometrium. Grasso A, Navarro R, Balaguer Cuenca N, Moreno Gimeno I, Alama P, Jimenez J, Simon Valles C, Vilella Mitjana F. Journal of Clinical Endocrinology & Metabolism. 2020 Mar 1;105(3):dgz146. doi: 10.1210/clinem/dgz146. PMID: 31665361

Identification and Characterization of Extracellular Vesicles and Its DNA Cargo Secreted During Murine Embryo Development. Simon B, Bolumar Recuero D, Amadoz A, Jiménez Almazán J, Valbuena Parilla D, Vilella Mitjana F, Moreno Gimeno I. Genes. 2020 Feb 17;11(2):203. doi: 10.3390/genes11020203. PMID: 32079252

Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos. Girardi L, Serdarogullari M, Patassini C, Poli M, Fabiani M, Caroselli S, Coban O, Findikli N, Boynukalin F, Bahceci M, Chopra R, Canipari R, Cimadomo D, Rienzi L, Ubaldi F, Hoffmann E, Rubio Lluesa C, Simon Valles C, Capalbo A. American Journal of Human Genetics. 2020 Apr 2;106(4):525-534. doi: 10.1016/j.ajhg.2020.03.005. PMID: 32220293

Introduction: How evident is the evidence?. Simon Valles C. Fertility and Sterility. 2020 Jun;113(6):1091-1092. doi: 10.1016/j.fertnstert.2020.03.018. PMID: 32482243

Menstruation: science and society. Critchley H, Babayev E, Bulun S, Clark S, Garcia-Grau I, Gregersen P, Kilcoyne A, Kim J, Lavender M, Marsh E, Matteson K, Maybin J, Metz C, Moreno I, Silk K, Sommer M, Simon C, Tariyal R, Taylor H, Wagner G, Griffith L. American Journal of Obstetrics and Gynecology. 2020 Nov;223(5):624-664. doi: 10.1016/j.ajog.2020.06.004. PMID: 32707266

Multicenter prospective study of concordance between embryo cell-free DNA and trophectoderm biopsies from 1,301 human blastocysts. Rubio Lluesa C, Navarro-Sanchez L, Garcia-Pascual C, Ocali O, Cimadomo D, Venier W, Barroso G, Kopcow L, Bahceci M, Roos Kulmann M, Lopez L, De La Fuente E, Navarro R, Valbuena Parilla D, Sakkas D, Rienzi L, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Nov;223(5):751.e1-751.e13. doi: 10.1016/j.ajog.2020.04.035. PMID: 32470458

Operative hysteroscopy should be repeated as many times as necessary for the treatment of refractory Asherman syndrome versus is there any alternative therapy worth considering?. Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):510. doi: 10.1016/j.fertnstert.2020.01.021. PMID: 32089254

Optimized NGS Approach for Detection of Aneuploidies and Mosaicism in PGT-A and Imbalances in PGT-SR. Garcia-Pascual C, Navarro-Sanchez L, Navarro R, Martinez L, Jimenez J, Rodrigo L, Simon Valles C, Rubio Lluesa C. Genes. 2020 Jun 29;11(7):724. doi: 10.3390/genes11070724. PMID: 32610655

Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data. Capalbo A, Poli M, Riera-Escamilla A, Shukla V, Kudo Hoffding M, Krausz C, Hoffmann E, Simon Valles C. Human Reproduction Update. 2020 Nov 16;dmaa044. doi: 10.1093/humupd/dmaa044. PMID: 33197264

Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2. Garrido Gomez T, Quinonero A, Dominguez F, Rubert L, Perales A, Hajjar K, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Apr;222(4):376.e1-376.e17. doi: 10.1016/j.ajog.2019.11.1250. PMID: 31738896

Preimplantation genetic testing for aneuploidy in patients with partial X monosomy using their own oocytes: is this a suitable indication?. Giles Jimenez J, Meseguer Escriva M, Mercader Bayarri A, Rubio Lluesa C, Alegre Ferri L, Vidal C, Trabalon M, Bosch Aparicio E. Fertility and Sterility. 2020 Aug;114(2):346-353. doi: 10.1016/j.fertnstert.2020.04.003. PMID: 32680612

Response to: Comments on the methodology of an endometrial receptivity array trial. Simon C, Gomez C, Ruiz M, Mol B, Valbuena D. Reproductive Biomedicine Online. 2020 Oct 3;S1472-6483(20)30533-2. doi: 10.1016/j.rbmo.2020.09.028. PMID: 33060012

Should we consider alternative therapies to operative hysteroscopy for the treatment of Asherman syndrome?. Santamaria Costa J, Liu J, Lusine A, Isaacson K, Movilla P, Fernandez H, Capmas P, Donnez J, Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):511-521. doi: 10.1016/j.fertnstert.2020.01.022. PMID: 32111470

Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle. Wang W, Vilella Mitjana F, Alama P, MORENO GIMENO I, Mignardi M, Isakova A, Pan W, Simon Valles C, Quake S. Nature Medicine. 2020 Oct;26(10):1644-1653. doi: 10.1038/s41591-020-1040-z. PMID: 32929266

Testing the mathematical model for PGT-A inefficiency with scientific sources demonstrates the efficacy of PGT-A. Capalbo A, Rubio Lluesa C, Simon Valles C. Human reproduction. 2020 Sep 1;35(9):2163-2165. doi: 10.1093/humrep/deaa172. PMID: 32766771

The dawn of the future: 30years from the first biopsy of a human embryo. The detailed history of an ongoing revolution. Cimadomo D, Rienzi L, Capalbo A, Rubio Lluesa C, Innocenti F, Garcia-Pascual C, Ubaldi F, Handyside A. Human Reproduction Update. 2020 Jun 18;26(4):453-473. doi: 10.1093/humupd/dmaa019. PMID: 32441746

The first glimpse of the endometrial microbiota in early pregnancy. Moreno Gimeno I, Garcia I, Bau D, Perez-Villaroya D, Gonzalez-Monfort M, Vilella Mitjana F, Romero R, Simon Valles C. American Journal of Obstetrics and Gynecology. 2020 Apr;222(4):296-305. doi: 10.1016/j.ajog.2020.01.031. PMID: 32057732

The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances. Monteagudo-Sanchez A, Hernandez Mora J, Simon C, Burton A, Tenorio J, Lapunzina P, Clark S, Esteller M, Kelsey G, Lopez-Siguero J, de Nanclares G, Torres-Padilla M, Monk D. Nucleic ACIDS Research. 2020 Nov 18;48(20):11394-11407. doi: 10.1093/nar/gkaa837. PMID: 33053156

Time to pregnancy: as important for patients as underestimated by doctors. Roque M, Simon Valles C. Fertility and Sterility. 2020 Mar;113(3):522-523. doi: 10.1016/j.fertnstert.2019.12.025. PMID: 32111473

Use of Customizable Nucleases for Gene Editing and Other Novel Applications. Reddy P, Vilella Mitjana F, Izpisua Belmonte J, Simon Valles C. Genes. 2020 Aug 22;11(9):976. doi: 10.3390/genes11090976. PMID: 32842577

25 historic papers: an ASRM 75th birthday gift from Fertility and Sterility. Niederberger C, Pellicer A, Simon C, Kathrins M, Goldstein M, Sigman M, Schlegel PN, Munné S, Gardner DK, Cobo A, Coutifaris C, Donnez J, Taylor HS, Giudice LC, Fauser BCJM, Lindheim SR, Rosenwaks Z, Casper RF, de Ziegler D, Gibbons WE, Paulson RJ, Laufer N, Klock SC, Mendola P, Sauer MV. Fertility and Sterility. 2019 Oct;112(4S1):e2-e27. doi: 10.1016/j.fertnstert.2019.08.099. PMID: 31623734

Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles. Carrasquillo RJ, Kohn TP, Cinnioglu C, Rubio C, Simon C, Ramasamy R, Al-Asmar N. Journal of Assisted Reproduction and Genetics. 2019 Oct;36(10):2039-2045. doi: 10.1007/s10815-019-01549-z. PMID: 31385121

An endometrial pathology in the inflammation cloud that can be accessed with a microbial app. Moreno I, Simon C. Fertility And Sterility. 2019 Apr;111(4):679-680. doi: 10.1016/j.fertnstert.2018.12.022. PMID: 30871763

Bioengineered uterus: a path toward ectogenesis. Bulletti C, Simon C. Fertility and Sterility. 2019 Sep;112(3):446-447. doi: 10.1016/j.fertnstert.2019.06.023. PMID: 31371052

Cellular therapies for the endometrium: An update. Queckbörner S, Davies LC, von Grothusen C, Santamaria X, Simón C, Gemzell-Danielsson K. Acta Obstetricia et Gynecologica Scandinavica. 2019 May;98(5):672-677. doi: 10.1111/aogs.13598. PMID: 30815850

Clinical application of embryo aneuploidy testing by NGS. Rubio C, Rodrigo L, Garcia-Pascual C, Peinado V, Campos-Galindo I, Garcia-Herrero S, Simón C. Biology of Reproduction. 2019 Dec 24;101(6):1083-1090. doi: 10.1093/biolre/ioz019. PMID: 30721942

Cost-effectiveness of preimplantation genetic testing for aneuploidies. Somigliana E, Busnelli A, Paffoni A, Vigano P, Riccaboni A, Rubio C, Capalbo A. Fertility and Sterility. 2019 Jun;111(6):1169-1176. doi: 10.1016/j.fertnstert.2019.01.025. PMID: 30777289

Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications. Rubio C, Rienzi L, Navarro-Sánchez L, Cimadomo D, García-Pascual CM, Albricci L, Soscia D, Valbuena D, Capalbo A, Ubaldi F, Simón C. Fertility and Sterility. 2019 Sep;112(3):510-519. doi: 10.1016/j.fertnstert.2019.04.038. PMID: 31200971

Happy Birthday to ASRM from Fertility and Sterility. Niederberger C, Pellicer A, Simon C. Fertility and Sterility. 2019 Oct;112(4S1):e1. doi: 10.1016/j.fertnstert.2019.08.098. PMID: 31623722

Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells. López-Pérez N, Gil-Sanchis C, Ferrero H, Faus A, Díaz A, Pellicer A, Cervelló I, Simón C. Reproductive Sciences. 2019 Jan;26(1):77-87. doi: 10.1177/1933719118766251. PMID: 29575998

Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR). Mateu-Brull E, Rodrigo L, Peinado V, Mercader A, Campos-Galindo I, Bronet F, García-Herrero S, Florensa M, Milán M, Rubio C. Journal of Assisted Reproduction and Genetics. 2019 Dec;36(12):2547-2555. doi: 10.1007/s10815-019-01593-9. PMID: 31696386

Introduction: Preconceptional care: do we have to care?. Simon C. Fertility and Sterility. 2019 Oct;112(4):611-612. doi: 10.1016/j.fertnstert.2019.08.056. PMID: 31561862

Is it time to reconsider microbial health in ART?. Moreno I. BJOG. 2019 Jan;126(2):208. doi: 10.1111/1471-0528.15219. PMID: 29542278

MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth. Balaguer N, Moreno I, Herrero M, Gonzáléz-Monfort M, Vilella F, Simón C. American Journal of Obstetrics and Gynecology. 2019 Jul;221(1):46.e1-46.e16. doi: 10.1016/j.ajog.2019.02.047. PMID: 30826341

Molecular differential diagnosis of uterine leiomyomas and leiomyosarcomas. Mas A, Simón C. Biology of Reproduction. 2019 Dec 24;101(6):1115-1123. doi: 10.1093/biolre/ioy195. PMID: 30184111

mtDNA dynamics between cleavage-stage embryos and blastocysts. De Munck N, Liñán A, Elkhatib I, Bayram A, Arnanz A, Rubio C, Garrido N, Lawrenz B, Fatemi HM. Journal of Assisted Reproduction and Genetics. 2019 Sep;36(9):1867-1875. doi: 10.1007/s10815-019-01544-4. PMID: 31392663

Optimizing clinical exome design for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes. Capalbo A, Valero RA, Jimenez-Almazan J, Pardo PM, Fabiani M, Jiménez D, Simon C, Rodriguez JM. PLOS Genetics. 2019 Oct 7;15(10):e1008409. doi: 10.1371/journal.pgen.1008409. PMID: 31589614

PGDIS Position Statement on the Transfer of Mosaic Embryos 2019. Cram DS, Leigh D, Handyside A, Rechitsky L, Xu K, Harton G, Grifo J, Rubio C, Fragouli E, Kahraman S, Forman E, Katz-Jaffe M, Tempest H, Thornhill A, Strom C, Escudero T, Qiao J, Munne S, Simpson JL, Kuliev A. Reproductive Biomedicine Online. 2019 Aug;39 Suppl 1:e1-e4. doi: 10.1016/j.rbmo.2019.06.012.. PMID: 31421710

Precision Medicine in Human Reproduction. Special Issue. Simon C, Sakkas D, Gardner D, Critchley H. Biology of Reproduction. 2019 Dec 24;101(6):1075. doi: 10.1093/biolre/ioz193. PMID: 31616936

Preconceptional care, where reproductive medicine meets obstetrics: the origins of lifetime health. Simon C, Romero R. Fertility and Sterility. 2019 Apr;111(4):657-658. doi: 10.1016/j.fertnstert.2019.02.006. PMID: 30929724

Reply: Bone marrow-derived endometrial cells: what you see is what you get. Santamaria X, Mas A, Cervelló I, Taylor HS, Simon C. Human Reproduction Update. 2019 Mar 1;25(2):274-275. doi: 10.1093/humupd/dmy042. PMID: 30601981

Selection of New Probiotics for Endometrial Health. Chenoll E, Moreno I, Sánchez M, Garcia-Grau I, Silva Á, González-Monfort M, Genovés S, Vilella F, Seco-Durban C, Simón C, Ramón D. Frontiers in Cellular and Infection Microbiology. 2019 Apr 17;9:114. doi: 10.3389/fcimb.2019.00114. PMID: 31058101

Should the reproductive risk of a couple aiming to conceive be tested in the contemporary clinical context?. Capalbo A, Chokoshvili D, Dugoff L, Franasiak J, Gleicher N, Pennings G, Simon C. Fertility and Sterility. 2019 Feb;111(2):229-238. doi: 10.1016/j.fertnstert.2018.11.045. PMID: 30642571

Sperm chromosomal abnormalities and their contribution to human embryo aneuploidy. Rodrigo L, Meseguer M, Mateu E, Mercader A, Peinado V, Bori L, Campos-Galindo I, Milán M, García-Herrero S, Simón C, Rubio C. Biology of Reproduction. 2019 Dec 24;101(6):1091-1101. doi: 10.1093/biolre/ioz125. PMID: 31318411

Taxonomical and Functional Assessment of the Endometrial Microbiota in A Context of Recurrent Reproductive Failure: A Case Report. Garcia-Grau I, Perez-Villaroya D, Bau D, Gonzalez-Monfort M, Vilella F, Moreno I, Simon C. Pathogens. 2019 Oct 24;8(4). pii: E205. doi: 10.3390/pathogens8040205. PMID: 31653041

The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing. Mas A, Alonso R, Garrido-Gómez T, Escorcia P, Montero B, Jiménez-Almazán J, Martín J, Pellicer N, Monleón J, Simón C. American Journal of Obstetrics and Gynecology. 2019 Oct;221(4):320.e1-320.e23. doi: 10.1016/j.ajog.2019.05.018. PMID: 31121144

To what extent is the testing of the reproductive risk of a couple aiming to conceive meaningful in the contemporary clinical context?. Simon C. Fertility and Sterility. 2019 Feb;111(2):227-228. doi: 10.1016/j.fertnstert.2018.11.046. PMID: 30642572

Unified diagnostic criteria for chronic endometritis at fluid hysteroscopy: proposal and reliability evaluation through an international randomized-controlled observer study. Cicinelli E, Vitagliano A, Kumar A, Lasmar RB, Bettocchi S, Haimovich S; International Working Group for Standardization of Chronic Endometritis Diagnosis. Fertility and Sterility. 2019 Jul;112(1):162-173.e2. doi: 10.1016/j.fertnstert.2019.03.004. PMID: 31104760

Uterine microbiome-low biomass and high expectations. Garcia-Grau I, Simon C, Moreno I. Biology of Reproduction. 2019 Dec 24;101(6):1102-1114. doi: 10.1093/biolre/ioy257. PMID: 30544156

Proyectos
Referencia: PROMETEO/2018/161
Título: Medicina regenerativa del útero humano: desde la terapia celular a la creación del órgano mediante bioingeniería
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Carlos Simón Vallés
Duración: 2018 – 2021
Presupuesto: 297.066 €

Referencia: FDGENT/2019/010
Título: Diagnóstico molecular de los miomas uterinos mediante secuenciación masiva
Entidad Financiadora: Conselleria de Innovación, Universidades y Ciencia
Investigador principal: Aymara Más Perucho
Duración: 2019 – 2023
Presupuesto:

Referencia: FDGENT/2019/008
Título: Estudio molecular sobre la etiología de la preeclampsia y nuevas estrategias para su detección precoz
Entidad Financiadora: Conselleria de Innovación, Universidades y Ciencia
Investigador principal: Tamara Garrido Gómez
Duración: 2019 – 2023
Presupuesto:

Referencia: PI20/00942
Título: Desarrollo de un modelo predictivo para el diagnóstico diferencial temprano de leiomiomas y leiomiosarcomas uterinos
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: Aymara Más Perucho
Duración: 2021 – 2023
Presupuesto: 99.825 €

Referencia: PI19/01659
Título: Análisis transcriptómico a nivel de célula única y tejido endometrial completo del fallo en decidualización presente en pacientes con preclampsia severa
Entidad Financiadora: Instituto de Salud Carlos III
Investigador principal: Tamara Garrido Gómez
Duración: 2020 – 2022
Presupuesto: 93.170 €

Referencia: RTI2018-094946-B-I00
Título: Contribución materna en la patogénesis de enfermedades gestacionales tardías como la preeclampsia
Entidad Financiadora: Ministerio de Ciencia, Innovación y Universidades
Investigador principal: Carlos Simón Vallés
Duración: 2019 – 2021
Presupuesto: 254.100 €

+ Información
Título: Epigenetic analysis of cell-free dna as a tool to study pathogenesis and maternal syndrome of preeclampsia
Doctorando: Corachán García, Irene
Director: Simón Vallés, Carlos; Díez Juan, Antonio; Vilella Mitjana, Felipe
Fecha: 14/02/2020
Universidad: Universitat de València

Título: Maternal-fetal crosstalk. Elucitaing the role of mir30d in endometrial receptivity and pregnancy outcome
Doctorando: Balaguer Cuenca, Nuria
Director: Vilella Mitjana, Felipe; Simón Vallés, Carlos
Fecha: 14/01/2019
Universidad: Universitat de València