Grupo de investigación cardiometabólica en atención primaria

Área de Cardiovascular

Consolidación de diversas líneas de investigación cardiometabólica

Consolidación de una red de colaboradores en el área de atención primaria

Dr. Jorge Navarro Pérez
Coordinador
Dr. Jorge Navarro Pérez
jorge.navarro@uv.es

INVESTIGADORES
R4 Senior

Jorge Navarro Pérez    

R3 Consolidado

Álvaro Bonet Pla
Carolina Mir Sánchez
Ruth Usó Talamantes

R2 Novel / Emergente
R1 Predoctoral
STAFF
Colaborador/a

Carlos Momparler Martínez
Carmina Martínez Vernia
Enrique Guinot Martínez
Irene Marco Moreno
Isabel Gabaldón Sánchez
José Luis Trillo Mata
Mª José Puchades Company
Marisa Gómez Arnedo
Nidia Ruiz Varea
Pablo Sabater Arnaldos
Pilar Botija Yagüe
Pilar Roca Navarro
Ruth Uribes Fillol
Tomás Sánchez Ruiz
Vibiana Blanco Alvarado
Victoria Gosalbes Soler

Enfermero/a
Técnico/a
Apoyo
Publicaciones
Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure. de la Espriella R, Amiguet M, Minana G, Rodriguez JC, Moyano P, Segarra D, Fernandez J, Santas E, Nunez G, Lorenzo M, Bonanad C, Alania E, Valle A, Sanchis J, Bodi V, Gorriz JL, Navarro J, Codina P, Voors AA, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Aug 6. doi: 10.1002/ejhf.2651. PMID: 36054502

Incidence and impact of atrial fibrillation in heart failure patients: real-world data in a large community. Diaz J, Martinez F, Calderon JM, Fernandez A, Sauri I, Uso R, Trillo JL, Redon J, Forner MJ. ESC Heart Failure. 2022 Sep 16. doi: 10.1002/ehf2.14124. PMID: 36111519

Long-term prognostic impact of estimated glomerular filtration rate on admission in patients hospitalized for acute heart failure. de la Espriella R, Navarro J, Mollar A, D’Marco L, Palau P, Minana G, Llacer P, Santas E, Heredia R, Gonzalez M, Gorriz JL, Codina P, Diez J, Bayes-Genis A, Nunez J. Cardiorenal Medicine. 2022 Oct 25;1-9. doi: 10.1159/000526105. PMID: 36282062

Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the comirnaty COVID-19 vaccine in nursing home residents. Sánchez-Sendra B, Albert E, Zulaica J, Torres I, Giménez E, Botija P, Beltrán MJ, Rodado C, Geller R, Navarro D. Scientific Reports. 2022 Mar 8;12(1):3788. doi: 10.1038/s41598-022-07849-2. PMID: 35260713

Real world data of anticoagulant treatment in non-valvular atrial fibrillation across renal function status. Calderon J, Martinez F, Fernandez A, Sauri I, Diaz J, Uso R, Trillo J, Redon J, Forner M. Scientific reports. 2022 Apr 12;12(1):6123. doi: 10.1038/s41598-022-10164-5. PMID: 35414001

Real-life performance of a COVID-19 rapid antigen detection test targeting the SARS-CoV-2 nucleoprotein for diagnosis of COVID-19 due to the Omicron variant. de Michelena P, Torres I, Ramos Garcia A, Gozalbes V, Ruiz N, Sanmartin A, Botija P, Poujois S, Huntley D, Albert E, Navarro D. Journal of Infection. 2022 Feb 22;S0163-4453(22)00110-4. doi: 10.1016/j.jinf.2022.02.022. PMID: 35217106

Real-world data of anticoagulant treatment in non-valvular atrial fibrillation. Calderon J, Martinez F, Diaz J, Fernandez A, Sauri I, Uso R, Trillo J, Vela S, Bea C, Redon J, Forner M. Frontiers In Cardiovascular Medicine. 2022 Jan 21;8:733300. doi: 10.3389/fcvm.2021.733300. PMID: 35127843

SARS-CoV-2 Omicron BA.1 variant breakthrough infections in nursing home residents after an homologous third dose of the Comirnaty (R) COVID-19 vaccine: looking for correlates of protection. Torres I, Gimenez E, Albert E, Zulaica J, Alvarez-Rodriguez B, Burgos J, Peiro S, Limon R, Vanaclocha H, Rodado C, Botija P, Sifre A, Tur B, Lozano R, Orosa I, Vicente-Ruiz M, Carrion R, Clari M, Sanchez-Paya J, Diez-Domingo J, Comas I, Gonzalez-Candelas F, Geller R, Navarro D. Journal of Medical Virology. 2022 Sep;94(9):4216-4223. doi: 10.1002/jmv.27867. PMID: 35585782

Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease. Gorriz J, Arroyo D, D’Marco L, Torra R, Tomas P, Puchades M, Panizo N, Pantoja J, Montomoli M, Llisterri J, Pallares-Carratala V, Valdivielso J. BMC nephrology. 2021 Mar 25;22(1):110. doi: 10.1186/s12882-021-02313-1. PMID: 33765945

Checklist for patients with type 2 diabetes mellitus for remote consultation. Angullo-Martinez E, Carretero-Anibarro E, Barrancos I, Claramunt X, Beltran D, Baile J, Loiola P, Grp Trabajo Diabet SemFyC. Atencion Primaria. 2021 Apr;53(4):101983. doi: 10.1016/j.aprim.2021.101983. PMID: 33743202

Cost of Type 2 diabetes patients with chronic kidney disease based on real-world data: an observational population-based study in Spain. Uso-Talamantes R, Gonzalez-de-Julian S, Diaz-Carnicero J, Sauri-Ferrer I, Trillo-Mata J, Carrasco-Perez M, Navarro-Perez J, Gorriz J, Vivas-Consuelo D, Redon J. International Journal of Environmental Research and Public Health. 2021 Sep 18;18(18):9853. doi: 10.3390/ijerph18189853. PMID: 34574782

Determining the burden of infectious diseases caused by carbapenem-resistant gram-negative bacteria in Spain. Canton R, Huarte R, Morata L, Trillo-Mata J, Munoz R, Gonzalez J, Tort M, Badia X. Enfermedades Infecciosas y Microbiologia Clinica. 2021 Apr;39(4):179-183. doi: 10.1016/j.eimc.2020.04.009. PMID: 32576392

Disorders in bone-mineral parameters and the risk of death in persons with chronic kidney disease stages 4 and 5: the PECERA study. Molina P, Molina M, Pallardo L, Torralba J, Escudero V, Alvarez L, Peris A, Sanchez-Perez P, Gonzalez-Rico M, Puchades M, Fernandez-Najera J, Gimenez-Civera E, D’Marco L, Carrero J, Gorriz J. Journal Of Nephrology. 2021 Aug;34(4):1189-1199. doi: 10.1007/s40620-020-00916-9. PMID: 33394344

Gender differences in the diagnosis of dyslipidemia: ESCARVAL-GENERO. Soriano-Maldonado C, Lopez-Pineda A, Orozco-Beltran D, Quesada JA, Alfonso-Sanchez JL, Pallares-Carratala V, Navarro-Perez J, Gil-Guillen VF, Martin-Moreno JM, Carratala-Munuera C. International Journal of Environmental Research and Public Health. 2021 Nov 25;18(23):12419. doi: 10.3390/ijerph182312419. PMID: 34886144

Gender inequalities in diagnostic inertia around the three most prevalent cardiovascular risk studies: protocol for a population-based cohort study. Carratala-Munuera C, Lopez-Pineda A, Orozco-Beltran D, Quesada J, Alfonso-Sanchez J, Pallares-Carratala V, Soriano-Maldonado C, Navarro-Perez J, Gil-Guillen V, Martin-Moreno J. International Journal of Environmental Research and Public Health. 2021 Apr 12;18(8):4054. doi: 10.3390/ijerph18084054. PMID: 33921396

Hospital admissions trends for severe hypoglycemia in diabetes patients in Spain, 2005 to 2015. Domingo O, Alberto G, Ana Maria C, Jorge N, Vicente G, Quesada-Rico Jose A, Pomares-Gomez Francisco J, Adriana L, Concepcion C. Diabetes Research and Clinical Practice. 2021 Jan;171:108565. doi: 10.1016/j.diabres.2020.108565. PMID: 33242511

Primary care at home in the framework of the COVID-19 pandemic. Cortes J, Sanchez C, Pajares P. Atencion Primaria. 2021 Mar;53(3):101963. doi: 10.1016/j.aprim.2020.12.004. PMID: 33517112

Renal function and attributable risk of death and cardiovascular hospitalization in participants with diabetes from a registry-based cohort. Ruiz-Quintero M, Redón Mas J, Tellez-Plaza M, Cebrian-Cuenca A, Navarro Perez J, Menendez E, Perez-Navarro A, Fernandez-Gimenez A, Lopez-Pineda A, Quesada J, Pallares-Carratala V, Gil-Guillen V, Martín Moreno J, Bleda-Cano J, Carrascosa S, Carratala-Munuera C. Primary Care Diabetes. 2021 Feb;15(1):88-94. doi: 10.1016/j.pcd.2020.06.004. PMID: 32646765

Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation. Martinez MT, Monton-Bueno J, Simon S, Ortega B, Moragon S, Rosello S, Insa A, Navarro J, Sanmartin A, Julve A, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner MJ, Cano A, Silvestre A, Teruel A, Lluch A, Cervantes A, Chirivella Gonzalez I. ESMO open. 2021 May 11;6(3):100148. doi: 10.1016/j.esmoop.2021.100148. PMID: 33989988

Therapeutic inertia in patients with type 2 diabetes treated with non-insulin agents. Ampudia-Blasco F, Palanca A, Trillo J, Navarro J, Real J. Journal of diabetes and its complications. 2021 Mar;35(3):107828. doi: 10.1016/j.jdiacomp.2020.107828. PMID: 33436143

A new risk score to assess atrial fibrillation risk in hypertensive patients (ESCARVAL-RISK Project. Orozco-Beltran D, Quesada J, Bertomeu-Gonzalez V, Lobos-Bejarano J, Navarro Perez J, Gil-Guillen V, Garcia Ortiz L, Lopez-Pineda A, Castellanos-Rodriguez A, Lopez-Domenech A, Cardona-Llorens A, Carratala-Munuera C. Scientific Reports. 2020 Mar 16;10(1):4796. doi: 10.1038/s41598-020-61437-w. PMID: 32179807

A randomized controlled trial on carbohydrate antigen 125-guided diuretic treatment versus usual care in patients with acute heart failure and renal dysfunction. Nuñez Villota J, Llacer P, Garcia Blas S, Bonanad Lozano C, Ventura S, Nunez J, Sanchez R, Facila De La Esperanza R, De La Espriella Juan R, Vaquer Santamaria J, Cordero A, Roque M, Chamorro C, Bodí Peris V, Valero Picher E, Santas Olmeda E, Del Carmen Moreno M, Miñana Escriva G, Carratalá Calvo A, Rodriguez Borja E, Mollar Fernandez A, Palau P, Bosch M, Bertomeu-Gonzalez V, Lupon J, Navarro Perez J, Chorro Gascó F, Górriz Teruel J, Sanchis Fores J, Voors A, Bayes-Genis A, IMPROVE-HF Investigators. American Journal of Medicine. 2020 Mar;133(3):370-380.e4. doi: 10.1016/j.amjmed.2019.07.041. PMID: 31422111

Acute kidney injury in heart failure: a population study. Holgado Sánchez J, Lopez Forte C, Fernández Giménez A, Saurí Ferrer M, Uso Talamantes R, Trillo Mata J, Vela Bernal S, Nuñez Villota J, Redón Mas J, Ruiz Hernandez A. Esc Heart Failure. 2020 Apr;7(2):415-422. doi: 10.1002/ehf2.12595. PMID: 32059081

Cardiovascular preventive recommendations. PAPPS 2020 update. Orozco-Beltran D, Brotons Cuixart C, Aleman Sanchez J, Banegas Banegas J, Cebrian-Cuenca A, Gil Guillen V, Martin Rioboo E, Navarro Perez J. Atencion Primaria. 2020 Nov;52 Suppl 2:5-31. doi: 10.1016/j.aprim.2020.08.002. PMID: 33388118

Co-detection of respiratory pathogens in patients hospitalized with Coronavirus viral disease-2019 pneumonia. Blasco Cortes M, Buesa Gomez J, Colomina Rodríguez F, Forner Giner M, Galindo Puerto M, Navarro Perez J, Noceda Bermejo J, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal Of Medical Virology. 2020 Oct;92(10):1799-1801. doi: 10.1002/jmv.25922. PMID: 32320082

Cost-effectiveness of Cladribine Tablets and fingolimod in the treatment of relapsing multiple sclerosis with high disease activity in Spain. Poveda J, Trillo Mata J, Rubio-Terres C, Rubio-Rodriguez D, Polanco A, Torres C. Expert Review of Pharmacoeconomics & Outcomes Research. 2020 Jun;20(3):295-303. doi: 10.1080/14737167.2019.1635014. PMID: 31220959

Epicardial Adipose Tissue, Adiponectin and Leptin: A Potential Source of Cardiovascular Risk in Chronic Kidney Disease. D’marco Gascón L, Puchades Company M, Górriz Teruel J, Romero Parra M, Lima-Martinez M, Soto C, Bermudez V, Raggi P. International Journal Of Molecular Sciences. 2020 Feb 1;21(3):978. doi: 10.3390/ijms21030978. PMID: 32024124

GLP-1 Receptor Agonists and Diabetic Kidney Disease: A Call of Attention to Nephrologists. Górriz Teruel J, Soler M, Navarro-Gonzalez J, Garcia-Carro C, Puchades M, D’marco Gascón L, Martinez Castelao A, Fernandez-Fernandez B, Ortiz A, Gorriz-Zambrano C, Navarro Perez J, Gorgojo-Martinez J. Journal of Clinical Medicine. 2020 Mar 30;9(4):947. doi: 10.3390/jcm9040947. PMID: 32235471

Impact of Acute Hemoglobin Falls in Heart Failure Patients: A Population Study. López Zumel M, Holgado Sánchez J, Ferrandez Izquierdo A, Saurí Ferrer M, Uso Talamantes R, Trillo Mata J, Vela Bernal S, Bea Serrano C, Nuñez Villota J, Ferrer Albero A, Gamez Payá J, Ruiz Hernandez A, Redón Mas J. Journal of Clinical Medicine. 2020 Jun 15;9(6):1869. doi: 10.3390/jcm9061869. PMID: 32549339

Noninvasive Imaging Estimation of Myocardial Iron Repletion Following Administration of Intravenous Iron: The Myocardial-IRON Trial. Nuñez Villota J, Miñana Escriva G, Cardells Beltran I, Palau P, Llacer P, Facila L, Almenar L, Lopez Lereu M, Monmeneu Menadas J, Amiguet Comins M, González D’gregorio J, Serrano Alcalá A, Montagud V, Lopez-Vilella R, Valero Picher E, Garcia Blas S, Bodí Peris V, De La Espriella Juan R, Lupon J, Navarro Perez J, Górriz Teruel J, Sanchis Fores J, Chorro Gascó F, Comin-Colet J, Bayes Genis A, Myocardial-IRON Investigators. Journal of the American Heart Association. 2020 Feb 18;9(4):e014254. doi: 10.1161/JAHA.119.014254. PMID: 32067585

Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19. de Dios E, Rios-Navarro C, Perez-Sole N, Gavara J, Marcos-Garces V, Rodríguez E, Carratalá A, Forner MJ, Navarro J, Blasco ML, Bondia E, Signes-Costa J, Vila JM, Forteza MJ, Chorro 1MJ, Bodi V. Journal of Clinical Medicine. 2020 Oct 28;9(11):E3484. doi: 10.3390/jcm9113484. PMID: 33126723

The influence of hemoglobin A1c levels on cardiovascular events and all-cause mortality in people with diabetes over 70 years of age. A prospective study. Orozco-Beltran D, Navarro Perez J, Cebrian-Cuenca A, Alvarez-Guisasola F, Caride-Miana E, Mora G, Quesada J, Lopez-Pineda A, Cardona-Llorens A, Redón Mas J, Gil-Guillen V, Ferrandez Izquierdo A, Carratala-Munuera C. Primary Care Diabetes. 2020 Dec;14(6):678-684. doi: 10.1016/j.pcd.2020.06.003. PMID: 32605878

Proyectos
Referencia: PI21/01417
Título: Cribado sistemático de insuficiencia cardíaca en pacientes con diabetes mellitus tipo 2. Estudio piloto
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Enrique Santas Olmeda, Jorge Navarro Pérez
Duración: 2022 – 2024
Presupuesto: 90.871 €
La insuficiencia cardiaca (IC) y la diabetes mellitus tipo 2 (DM2) son dos patologías estrechamente relacionadas con un alto impacto sociosanitario. El objetivo del presente trabajo es realizar un proyecto de cribado sistemático de IC en una población no seleccionada de sujetos con DM2, con el objetivo de estimar la prevalencia de IC en nuestro medio.
Referencia: PI16/02130
Título: Impacto de la auto-medición y el auto-ajuste de la medicación antihipertensiva en el control de la hipertensión arterial. Un ensayo clínico pragmático: estudio ADAMPA
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Jorge Navarro Pérez
Duración: 2017 – 2021
Presupuesto: 86.515 €

+ Información
Título: Análisis de los determinantes socioeconómicos y de la morbilidad del Departamento de Salud Valencia Clínico-Malvarrosa. Desarrollo de un índice de privación poblacional integrado
Doctorando: Pilar Botija Yagüe
Director: Usó Talamantes, Ruth; Navarro Pérez, Jorge; Botija Yagüe, Mª de las Mercedes
Fecha: 30/11/2021
Universidad: Universitat de València

Título: Efectividad de una intervención de automanejo de la hipertensión arterial en la mejora de la inercia terapéutica y la adherencia a los medicamentos antihipertensivos. Ensayo clínico pragmático ADAMPA
Doctorando: Marco Moreno, Irene
Director: Sanfélix, Gabriel; Peiró Moreno, Salvador; San Félix Genovés, Jose
Fecha: 28/04/2021
Universidad: Universitat de València

Título: Análisis epidemiológico de la fibromialgia en la Comunidad Valenciana
Doctorando: Cabo Meseguer, Asensio Francisco
Director: Trillo Mata, Jose Luis; Cerdá Olmedo, Germán
Fecha: 25/02/2019
Universidad: Universidad Católica de Valencia San Vicente Mártir