Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology. Bayes-Genis A, Aimo A, Jhund P, Richards M, de Boer RA, Arfsten H, Fabiani I, Lupon J, Anker SD, Gonzalez A, Castiglione V, Metra M, Mueller C, Nunez J, Rossignol P, Barison A, Butler J, Teerlink J, Filippatos G, Ponikowski P, Vergaro G, Zannad F, Seferovic P, Rosano G, Coats AJS, Emdin M, Januzzi, JL. European Journal of Heart Failure. 2022 Oct;24(10):1767-1777. doi: 10.1002/ejhf.2675. PMID: 36073112

Carbohydrate antigen 125 (CA125) as a prognostic marker in the elderly with acute heart failure and preserved ejection fraction. Llacer P, Nunez J, Manzano L, Rodrigo J, Bautista P, Garcia M, Vila J, Lopez R, Reboiro M, Montero-Perez-Barquero M. Medicina Clinica. 2022 Aug 26;159(4):164-170. doi: 10.1016/j.medcli.2021.09.032. PMID: 34895749

Carbohydrate antigen 125 and risk of heart failure readmissions in patients with heart failure and preserved ejection fraction. Minana G, de la Espriella R, Palau P, Llacer P, Nunez E, Santas E, Valero E, Lorenzo M, Nunez G, Bodi V, Heredia R, Sanchis J, Bayes-Genis A, Chorro F, Nunez J. Scientific Reports. 2022 Jan 25;12(1):1344. doi: 10.1038/s41598-022-05328-2. PMID: 35079082

Cardiac remodelling part 1: from cells and tissues to circulating biomarkers. Gonzalez A, Richards A, de Boer R, Thum T, Arfsten H, Hulsmann M, Falcao-Pires I, Diez J, Foo R, Chan M, Aimo A, Anene-Nzelu G, Abdelhamid M, Adamopoulos S, Anker S, Belenkov Y, Gal T, Cohen-Solal A, Bohm M, Chioncel O, Delgado V, Emdin M, Jankowska E, Gustafsson F, Hill L, Jaarsma T, Januzzi J, Jhund P, Lopatin Y, Lund L, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Nunez J, Piepoli M, Rakisheva A, Ristic A, Rossignol P, Savarese G, Tocchetti C, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats A, Bayes-Genis A. European Journal of Heart Failure. 2022 Jun;24(6):927-943. doi: 10.1002/ejhf.2493. PMID: 35334137

Cardiac remodelling-Part 2: clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology. Aimo A, Vergaro G, Gonzalez A, Barison A, Lupon J, Delgado V, Richards AM, de Boer RA, Thum T, Arfsten H, Hulsmann M, Falcao-Pires I, Diez J, Foo RSY, Chan MYY, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Gal TB, Cohen-Solal A, Bohm M, Chioncel O, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund P, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Nunez J, Piepoli MF, Rakisheva A, Ristic AD, Rossignol P, Savarese G, Tocchetti CG, van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJS, Emdin M, Bayes-Genis A. European Journal of Heart Failure. 2022 Jun;24(6):944-958. doi: 10.1002/ejhf.2522. PMID: 35488811

Chronotropic index and long-term outcomes in heart failure with preserved ejection fraction. Palau P, Dominguez E, Seller J, Sastre C, Sanchis J, Lopez L, Bodi V, Llacer P, Minana G, Espriella R, Bayes-Genis A, Nunez J. Revista Espanola de Cardiologia (English ed.). 2022 Aug 28;S1885-5857(22)00211-0. doi: 10.1016/j.rec.2022.08.003. PMID: 36038124

Clinical characteristics and risk factors for mortality on admission in patients with heart failure hospitalized due to COVID-19 in Spain. Llacer Iborra P, Nunez Villota J. Revista Clinica Española. 2022 May;222(5):299-300. doi: 10.1016/j.rceng.2022.02.002. PMID: 35512909

Clinical characteristics and risk factors for mortality on admission in patients with heart failure hospitalized due to COVID-19 in Spain. Llacer P, Nunez J. Revista Clinica Española. 2022 May;222(5):299-300. doi: 10.1016/j.rce.2022.02.006. PMID: 35250040

Clinical recommendations to manage gastrointestinal adverse events in patients treated with Glp-1 receptor agonists: a multidisciplinary expert consensus. Gorgojo-Martinez JJ, Mezquita-Raya P, Carretero-Gomez J, Castro A, Cebrian-Cuenca A, De Torres-Sanchez A, Garcia-de-Lucas MD, Nunez J, Obaya JC, Soler MJ, Gorriz JL, Rubio-Herrera MA. Journal of Clinical Medicine. 2022 Dec 24;12(1):145. doi: 10.3390/jcm12010145. PMID: 36614945

Combined assessment of stress cardiovascular magnetic resonance and angiography to predict the effect of revascularization in chronic coronary syndrome patients. Gavara J, Perez N, Marcos-Garces V, Monmeneu J, Lopez-Lereu M, Rios-Navarro C, de Dios E, Bonanad C, Canoves J, Moratal D, Palau P, Minana G, Nunez J, Chorro F, Bodi V. European Journal of Preventive Cardiology. 2022 Mar 11;29(2):407-416. doi: 10.1093/eurjpc/zwab170. PMID: 34686874

Comments on the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. SEC Working Group for the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure and SEC Guidelines Committee. Revista Espanola De Cardiologia (english Ed.). 2022 Jun;75(6):458-465. doi: 10.1016/j.rec.2021.11.023. PMID: 35190290

Comparison of chlorthalidone and spironolactone as additional diuretic therapy in patients with acute heart failure and preserved ejection fraction. Llacer P, Nunez J, Garcia M, Ruiz R, Lopez G, Fabregate M, Fernandez C, Croset F, Del Hoyo B, Gomis A, Manzano L. European Heart Journal. Acute Cardiovascular Care. 2022 Jun 7;11(4):350-355. doi: 10.1093/ehjacc/zuac006. PMID: 35167653

Congestion in heart failure: a circulating biomarker-based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology. Nunez J, de la Espriella R, Rossignol P, Voors AA, Mullens W, Metra M, Chioncel O, Januzzi JL, Mueller C, Richards AM, de Boer RA, Thum T, Arfsten H, Gonzalez A, Abdelhamid M, Adamopoulos S, Anker SD, Gal TB, Biegus J, Cohen-Solal A, Boehm M, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Jhund PS, Lopatin Y, Lund LH, Milicic D, Moura B, Piepoli MF, Ponikowski P, Rakisheva A, Ristic A, Savarese G, Tocchetti CG, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJS, Bayes-Genis A. European Journal of Heart Failure. 2022 Oct;24(10):1751-1766. doi: 10.1002/ejhf.2664. PMID: 36039656

Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. Solomon S, McMurray J, Claggett B, de Boer R, DeMets D, Hernandez A, Inzucchi S, Kosiborod M, Lam C, Martinez F, Shah S, Desai A, Jhund P, Belohlavek J, Chiang C, Borleffs C, Comin-Colet J, Dobreanu D, Drozdz J, Fang J, Alcocer-Gamba M, Al Habeeb W, Han Y, Honorio J, Janssens S, Katova T, Kitakaze M, Merkely B, O’Meara E, Saraiva J, Tereshchenko S, Thierer J, Vaduganathan M, Vardeny O, Verma S, Pham V, Wilderang U, Zaozerska N, Bachus E, Lindholm D, Petersson M, Langkilde A. New England Journal of Medicine. 2022 Sep 22;387(12):1089-1098. doi: 10.1056/NEJMoa2206286. PMID: 36027570

Decongestion, kidney injury and prognosis in patients with acute heart failure. Horiuchi Y, Wettersten N, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Mueller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Duff S, Maisel A, Murray PT. International Journal of Cardiology. 2022 May 1;354:29-37. doi: 10.1016/j.ijcard.2022.02.026. PMID: 35202737

Dysglycaemia and high natriuretic peptides: the prelude to heart failure. Bayes-Genis A, Nunez J, Lupon J. European Journal of Heart Failure. 2022 Feb;24(2):254-256. doi: 10.1002/ejhf.2410. PMID: 34957645

Early carbohydrate antigen 125 as a mortality predictor in hospitalized patients with coronavirus disease 2019. Moreno-Perez O, Nunez J, Sandin-Rollan M, Arrarte V, Boix V, Reus S, Pinargote-Celorio H, Ribes I, Alfayate R, Llorca-Santos M, Martinez-Garcia M, Chico-Sanchez P, Merino E. Frontiers In Cardiovascular Medicine. 2022 Oct 20;9:941512. doi: 10.3389/fcvm.2022.941512. PMID: 36337886

Effect of a home-based inspiratory muscle training programme on functional capacity in postdischarged patients with long COVID: the InsCOVID trial. Palau P, Dominguez E, Gonzalez C, Bondia E, Albiach C, Sastre C, Martinez M, Nunez J, Lopez L. BMJ Open Respiratory Research. 2022 Dec;9(1):e001439. doi: 10.1136/bmjresp-2022-001439. PMID: 36549786

Efficacy and safety of subcutaneous infusion of non-formulated furosemide in patients with worsening heart failure: a real-world study. Civera J, de la Espriella R, Heredia R, Minana G, Santas E, Conesa A, Mollar A, Sastre C, Martinez A, Villaescusa A, Nunez J. Journal of Cardiovascular Translational Research. 2022 Jun;15(3):644-652. doi: 10.1007/s12265-021-10173-1. PMID: 34642870

EpCAM and microvascular obstruction in patients with STEMI: a cardiac magnetic resonance study. Rios-Navarro C, Gavara J, Nunez J, Revuelta-Lopez E, Monmeneu JV, Lopez-Lereu MP, de Dios E, Perez-Sole N, Vila JM, Oltra R, Chorro FJ, Bayes-Genis A, Bodi V. Revista Espanola de Cardiologia (English ed.). 2022 May;75(5):384-391. doi: 10.1016/j.rec.2021.04.006. PMID: 34045168

Evaluation of the effect of intravenous nitroglycerine on short-term survival of patients with acute heart failure according to congestion and perfusion status at emergency department arrival. Miro O, Espinosa B, Gil V, Jacob J, Alquezar-Arbe A, Masip J, Llauger L, Tost J, Andueza J, Garrido J, Mojarro E, Urbano C, Nunez J, Chioncel O, Mullens W, Cotter G, Llorens P. European Journal of Emergency Medicine. 2022 Dec 1;29(6):437-449. doi: 10.1097/MEJ.0000000000000964. PMID: 35861663

Frailty and hospitalization burden in patients with chronic heart failure. Mollar A, Bonanad C, Diez-Villanueva P, Segarra D, Civera J, Sastre C, Conesa A, Villaescusa A, Fernández J, Miñana G, Navarro J, Sanchis J, Núñez J. American Journal of Cardiology. 2022 Nov 15;183:48-54. doi: 10.1016/j.amjcard.2022.08.013. PMID: 36153181

Global warming, renal function and heart failure over 20years. Aimo A, Lupon J, Spitaleri G, Domingo M, Codina P, Santiago-Vacas E, Cediel G, Zamora E, Troya M, Santesmases J, Romero-Gonzalez G, Nunez J, Martini N, Emdin M, Bayes-Genis A. International Journal of Cardiology. 2022 Oct 15;365:100-105. doi: 10.1016/j.ijcard.2022.07.043. PMID: 35926642

Head-to-head comparison between recommendations by the ESC and ACC/AHA/HFSA Heart Failure Guidelines. Bayes-Genis A, Aimo A, Metra M, Anker S, Seferovic P, Rapezzi C, Castiglione V, Nunez J, Emdin M, Rosano G, Coats AJs. European Journal of Heart Failure. 2022 Jun;24(6):916-926. doi: 10.1002/ejhf.2542. PMID: 35579428

Hospitalization following an emergency-department visit for worsening heart failure: the role of left ventricular ejection fraction. Mollar A, Lorenzo M, Villaescusa A, Heredia R, Minana G, Santas E, de la Espriella R, Sastre C, Civera J, Martinez A, Conesa A, Sanchis J, Nunez E, Bayes-Genis A, Nunez J. Medicina Clinica. 2022 Aug 26;159(4):157-163. doi: 10.1016/j.medcli.2021.09.026. PMID: 35065819

Impact of congestion and perfusion status in the emergency department on severity of decompensation and short-term prognosis in patients with acute heart failure. Espinosa B, Llorens P, Gil V, Jacob J, Alquezar-Arbe A, Masip J, Llauger L, Tost J, Andueza JA, Garrido JM, Soy-Ferrer E, Aguera-Urbano C, Herrero P, Gil-Rodrigo A, Millan J, Mecina AB, Torres-Garate R, Cabrera-Gonzalez N, Nunez J, Miro O. European Heart Journal. Acute Cardiovascular Care. 2022 Sep 22;zuac115. doi: 10.1093/ehjacc/zuac115. PMID: 36137176

Incidence, treatment and clinical impact of iron deficiency in chronic heart failure: a longitudinal analysis. Minana G, Lorenzo M, Ramirez de Arellano A, Wachter S, de la Espriella R, Sastre C, Mollar A, Nunez E, Bodi V, Sanchis J, Bayes-Genis A, Nunez J. Journal of Clinical Medicine. 2022 May 2;11(9):2559. doi: 10.3390/jcm11092559. PMID: 35566684

Individualizing the treatment of patients with heart failure with reduced ejection fraction: a journey from hospitalization to long-term outpatient care. Escobar C, Luis-Bonilla J, Crespo-Leiro M, Esteban-Fernandez A, Farre N, Garcia A, Nunez J. Expert Opinion on Pharmacotherapy. 2022 Oct;23(14):1589-1599. doi: 10.1080/14656566.2022.2116275. PMID: 35995759

Light at the end of the tunnel of preserved heart failure, although important improvements are still necessary. Nunez J, de la Espriella R, Formiga F. Revista Portuguesa de Cardiología. 2022 Oct;41(10):897-898. doi: 10.1016/j.repc.2022.01.008. PMID: 36207070

Long-term mortality and trajectory of potassium measurements following an episode of acute severe hyperkalemia. Gorriz J, D’Marco L, Pastor-Gonzalez A, Molina P, Gonzalez-Rico M, Puchades M, Sanchis I, Escudero V, Estan N, de la Espriella R, Nunez E, Pallardo L, Nunez J. Nephrology, dialysis, transplantation. 2022 Feb 25;37(3):522-530. doi: 10.1093/ndt/gfab003. PMID: 33508124

Long-term prognostic impact of estimated glomerular filtration rate on admission in patients hospitalized for acute heart failure. de la Espriella R, Navarro J, Mollar A, D’Marco L, Palau P, Minana G, Llacer P, Santas E, Heredia R, Gonzalez M, Gorriz JL, Codina P, Diez J, Bayes-Genis A, Nunez J. Cardiorenal Medicine. 2022 Oct 25;1-9. doi: 10.1159/000526105. PMID: 36282062

Magnetic resonance assessment of left ventricular ejection fraction at any time post-infarction for prediction of subsequent events in a large multicenter STEMI Registry. Gavara J, Marcos-Garces V, Lopez-Lereu, MP, Monmeneu JV, Rios-Navarro C, de Dios E, Perez N, Merenciano H, Gabaldon A, Canoves J, Racugno P, Bonanad C, Minana G, Nunez J, Nunez E, Moratal D, Chorro FJ, Valente F, Lorenzatti D, Rodriguez-Palomares JF, Ortiz-Perez JT, Bodi V. Journal of Magnetic Resonance Imaging. 2022 Aug;56(2):476-487. doi: 10.1002/jmri.27789. PMID: 34137478

Mortality and heart failure risk reductions in patients treated with sacubitril-valsartan in clinical trials. Cordero A, Nunez J, Bertomeu-Gonzalez V, Facila L, Quintanilla M, Rodriguez-Manero M, Escribano D, Valle A, de la Espriella R, Torres-Llergo J, Bayes-Genis A, Gonzalez-Juanatey J. American Journal of Therapeutics. 2022 Sep-Oct 01;29(5):e572-e575. doi: 10.1097/MJT.0000000000001503. PMID: 36074989

Mortality risk prediction dynamics after heart failure treatment optimization: repeat risk assessment using online risk calculators. Codina P, Zamora E, Levy W, Revuelta-Lopez E, Borrellas A, Spitaleri G, Cediel G, Ruiz-Cueto M, Canedo E, Santiago-Vacas E, Domingo M, Buchaca D, Subirana I, Santesmases J, de la Espriella R, Nunez J, Lupon J, Bayes-Genis A. Frontiers In Cardiovascular Medicine. 2022 Apr 12;9:836451. doi: 10.3389/fcvm.2022.836451. PMID: 35498033

Optimal carbohydrate antigen 125 cutpoint for identifying low-risk patients after admission for acute heart failure. Nunez J, Bayes-Genis A, Revuelta-Lopez E, Minana G, Santas E, Ter Maaten J, de la Espriella R, Carratala A, Lorenzo M, Palau P, Llacer P, Valle A, Bodi V, Nunez E, Lupon J, Lang C, Ng L, Metra M, Sanchis J, Voors A. Revista Espanola de Cardiologia (english Ed.). 2022 Apr;75(4):316-324. doi: 10.1016/j.rec.2021.02.002. PMID: 33745912

Prognostic value of cardiac magnetic resonance early after ST-segment elevation myocardial infarction in older patients. Gabaldón-Pérez A, Marcos-Garcés V, Gavara J, López-Lereu MP, Monmeneu JV, Pérez N, Ríos-Navarro C, De Dios E, Merenciano-González H, Cànoves J, Racugno P, Bonanad C, Minana G, Núnez J, Moratal D, Chorro FJ, Valente F, Lorenzatti D, Ortiz-Pérez JT, Rodríguez-Palomares JF, Bodí V. Age and Ageing. 2022 Nov 2;51(11):afac248. doi: 10.1093/ageing/afac248. PMID: 36436010

Prognostic value of NT-proBNP and CA125 across glomerular filtration rate categories in acute heart failure. De la Espriella R, Bayes-Genis A, Llacer P, Palau P, Minana G, Santas E, Pellicer M, Gonzalez M, Gorriz JL, Bodi V, Sanchis J, Nunez J. European Journal of Internal Medicine. 2022 Jan;95:67-73. doi: 10.1016/j.ejim.2021.08.024. PMID: 34507853

Rationale and design of the dapagliflozin after transcatheter aortic valve implantation (DapaTAVI) randomized trial. Amat-Santos I, Sanchez-Luna J, Abu-Assi E, Melendo Viu M, Cruz-Gonzalez I, Nombela-Franco L, Munoz Garcia A, Garcia Blas S, de la Torre Hernandez J, Romaguera R, Sanchez-Recalde A, Diez Gil J, Lopez Otero D, Gheorge L, Ibanez B, Iniguez Romo A, Raposeiras-Roubin S, Dapagliflozin after Transcatheter Aortic Valve Implantation (DapaTAVI), investigators. European Journal of Heart Failure. 2022 Mar;24(3):581-588. doi: 10.1002/ejhf.2370. PMID: 34693613

Reply to the Letter regarding the article ‘Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure. de la Espriella R, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Dec;24(12):2391-2392. doi: 10.1002/ejhf.2717. PMID: 36225111

Reply to the Letter to the Editor to the article Comparison between CA125 and NT-proBNP for evaluating congestion in acute heart failure. Llacer P, Manzano L, Nunez J. Medicina Clinica. 2022 Jul 8;159(1):e2. doi: 10.1016/j.medcli.2022.01.023. PMID: 35545477

Reply: Beta-blocker withdrawal and chronotropic incompetence in heart failure with preserved ejection fraction. Palau P, Seller J, Domínguez E, Bayés-Genís A, Núñez J. Journal of the American College of Cardiology. 2022 Mar 8;79(9):e197-e198. doi: 10.1016/j.jacc.2022.01.002. PMID: 35241230

Risk score for early risk prediction by cardiac magnetic resonance after acute myocardial infarction. Marcos-Garces V, Perez N, Gavara J, Lopez-Lereu MP, Monmeneu JV, Rios-Navarro C, de Dios E, Merenciano-Gonzalez H, Gabaldon-Perez A, Canoves J, Racugno P, Bonanad C, Minana G, Nunez J, Moratal D, Chorro FJ, Valente F, Lorenzatti D, Ortiz-Perez JT, Rodriguez-Palomares JF, Bodi V. International Journal of Cardiology. 2022 Feb 15;349:150-154. doi: 10.1016/j.ijcard.2021.11.050. PMID: 34826497

Sacubitril/valsartan affects pulmonary arterial pressure in heart failure with preserved ejection fraction and pulmonary hypertension. Codina P, Domingo M, Barcelo E, Gastelurrutia P, Casquete D, Vila J, Altisent O, Spitaleri G, Cediel G, Santiago-Vacas E, Zamora E, Ruiz-Cueto M, Santesmases J, de la Espriella R, Pascual-Figal D, Nunez J, Lupon J, Bayes-Genis A. ESC Heart Failure. 2022 Aug;9(4):2170-2180. doi: 10.1002/ehf2.13952. PMID: 35588235

Serum potassium dynamics during acute heart failure hospitalization. Caravaca Perez P, Gonzalez-Juanatey J, Nuche J, Moran Fernandez L, Lora Pablos D, Alvarez-Garcia J, Bascompte Claret R, Martinez Selles M, Vazquez Garcia R, Martinez Dolz L, Cobo-Marcos M, Pascual Figal D, Crespo-Leiro M, Nunez Villota J, Cinca Cuscullola J, Delgado J. Clinical Research in Cardiology. 2022 Apr;111(4):368-379. doi: 10.1007/s00392-020-01753-3. PMID: 33070219

Sex effect in the decision to perform invasive coronary angiography in patients with chronic coronary syndrome after undergoing vasodilator stress MRI. Palau P, Nunez J, Monmeneu J, Lopez-Lereu M, Gavara J, Rios-Navarro C, de Dios E, Perez-Sole N, Marcos-Garces V, Dominguez E, Moratal D, Canoves J, Minana G, Chorro F, Bodi V. Journal of Magnetic Resonance Imaging. 2022 Dec;56(6):1680-1690. doi: 10.1002/jmri.28163. PMID: 35344231

Sex-related differences in mortality following admission for acute heart failure across the left ventricular ejection fraction spectrum. Santas E, Palau P, Llacer P, de la Espriella R, Minana G, Nunez-Marin G, Lorenzo M, Heredia R, Sanchis J, Chorro FJ, Bayes-Genis A, Nunez J. Journal of the American Heart Association. 2022 Jan 4;11(1):e022404. doi: 10.1161/JAHA.121.022404. PMID: 34927464

Short-term changes in left and right ventricular cardiac magnetic resonance feature tracking strain following ferric carboxymaltose in patients with heart failure: a substudy of the Myocardial-IRON Trial. Del Canto I, Santas E, Cardells I, Minana G, Palau P, Llacer P, Facila L, Lopez-Vilella R, Almenar L, Bodi V, Lopez-Lereu M, Monmeneu J, Sanchis J, Moratal D, Maceira A, de la Espriella R, Chorro F, Bayes-Genis A, Nunez J. Journal of the American Heart Association. 2022 Apr 5;11(7):e022214. doi: 10.1161/JAHA.121.022214. PMID: 35301854

Short-term effects of dapagliflozin on maximal functional capacity in heart failure with reduced ejection fraction (DAPA-VO2): a randomized clinical trial. Palau P, Amiguet M, Dominguez E, Sastre C, Mollar A, Seller J, Pinilla J, Larumbe A, Valle A, Doblas J, de la Espriella R, Minana G, Mezcua A, Santas E, Bodi V, Sanchis J, Pascual-Figal D, Gorriz J, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Oct;24(10):1816-1826. doi: 10.1002/ejhf.2560. PMID: 35604416

Stress cardiac magnetic resonance for mortality prediction and decision-making: registry of 2496 elderly patients with chronic coronary syndrome. Gabaldon-Perez A, Bonanad C, Garcia-Blas S, Gavara J, Rios-Navarro C, Perez-Sole N, de Dios E, Marcos-Garces V, Merenciano-Gonzalez H, Monmeneu J, Lopez-Lereu M, Nunez J, Chorro F, Bodi V. Revista Espanola de Cardiologia (english Ed.). 2022 Mar;75(3):223-231. doi: 10.1016/j.rec.2021.08.004. PMID: 34548244

Utility of plasma CA125 as a proxy of intra-abdominal pressure in patients with acute heart failure. Rubio-Gracia J, Crespo-Aznarez S, De la Espriella R, Nunez G, Sanchez-Marteles M, Garces-Horna V, Yanguas-Barea N, Josa-Laorden C, Cobo-Marcos M, Gimenez-Lopez I, Perez-Calvo JI, Nunez J. European Heart Journal-Acute Cardiovascular Care. 2022 Jun 22;11(6):453-460. doi: 10.1093/ehjacc/zuac046. PMID: 35512321

Venous leg compression for tissue decongestion in patients with worsening congestive heart failure. Civera J, Minana G, de la Espriella R, Santas E, Sastre C, Mollar A, Conesa A, Martinez A, Nunez E, Bayes-Genis A, Nunez J. Frontiers In Cardiovascular Medicine. 2022 Jul 8;9:847450. doi: 10.3389/fcvm.2022.847450. PMID: 35872894

Circulating neprilysin hypothesis: a new opportunity for sacubitril/valsartan in patients with heart failure and preserved ejection fraction?. Lupon J, Santiago-Vacas E, Cediel G, Codina P, Domingo M, Revuelta-Lopez E, Zamora E, Spitaleri G, Santesmases J, Nunez J, Bayes-Genis A. PLoS One. 2021 May 14;16(5):e0249674. doi: 10.1371/journal.pone.0249674. PMID: 33989294

Clinical history and detectable troponin concentrations below the 99th percentile for risk stratification of patients with chest pain and first normal troponin. Fernandez-Cisnal A, Valero E, Garcia-Blas S, Pernias V, Pozo A, Carratala A, Gonzalez J, Noceda J, Minana G, Nunez J, Sanchis J. Journal of Clinical Medicine. 2021 Apr 20;10(8):1784. doi: 10.3390/jcm10081784. PMID: 33923925

Clinical outcomes and response to vericiguat according to index heart failure event: insights from the VICTORIA trial. Lam C, Giczewska A, Sliwa K, Edelmann F, Refsgaard J, Bocchi E, Ezekowitz J, Hernandez A, O’Connor C, Roessig L, Patel M, Pieske B, Anstrom K, Armstrong P, VICTORIA Study Grp. JAMA Cardiology. 2021 Jun 1;6(6):706-712. doi: 10.1001/jamacardio.2020.6455. PMID: 33185650

Clinical utility of antigen carbohydrate 125 for planning the optimal length of stay in acute heart failure. Lorenzo M, Palau P, Llacer P, Dominguez E, Ventura B, Nunez G, Minana G, Solsona J, Santas E, De La Espriella R, Bodi V, Nunez E, Sanchis J, Bayes-Genis A, Nunez J. European Journal of Internal Medicine. 2021 Oct;92:94-99. doi: 10.1016/j.ejim.2021.05.037. PMID: 34130879

Comorbidity burden and revascularization benefit in elderly patients with acute coronary syndrome. Sanchis Fores J, Garcia Acuna J, Raposeiras S, Barrabes J, Cordero A, Martinez-Selles M, Bardaji A, Diez-Villanueva P, Marin F, Ruiz-Nodar J, Vicente-Ibarra N, Alonso Salinas G, Rigueiro P, Abu-Assi E, Formiga F, Nuñez Villota J, Nuñez Benito E, Ariza-Sole A. Revista Espanola de Cardiologia (English ed.). 2021 Sep;74(9):765-772. doi: 10.1016/j.rec.2020.06.015. PMID: 32778402

Comparison between CA125 and NT-proBNP for evaluating congestion in acute heart failure. Llacer P, Gallardo M, Palau Sampio P, Moreno M, Castillo C, Fernandez C, De La Espriella Juan R, Mollar Fernandez A, Santas Olmeda E, Miñana Escriva G, Manzano L, Bayes-Genis A, Nuñez Villota J. Medicina Clinica. 2021 Jun 25;156(12):589-594. doi: 10.1016/j.medcli.2020.05.063. PMID: 32951882

Coronary Revascularization and Long-Term Survivorship in Chronic Coronary Syndrome. Gabaldon-Perez A, Marcos-Garces V, Gavara J, Rios-Navarro C, Minana G, Bayes-Genis A, Husser O, Sanchis J, Nunez J, Chorro F, Bodi V. Journal of Clinical Medicine. 2021 Feb 5;10(4):610. doi: 10.3390/jcm10040610. PMID: 33562869

Decoding empagliflozin’s molecular mechanism of action in heart failure with preserved ejection fraction using artificial intelligence. Bayes-Genis A, Iborra-Egea O, Spitaleri G, Domingo M, Revuelta-Lopez E, Codina P, Cediel G, Santiago-Vacas E, Cserkoova A, Pascual-Figal D, Nunez J, Lupon J. Scientific Reports. 2021 Jun 8;11(1):12025. doi: 10.1038/s41598-021-91546-z. PMID: 34103605

Decongestion discriminates risk for one-year mortality in patients with improving renal function in acute heart failure. Wettersten N, Horiuchi Y, van Veldhuisen D, Ix J, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, Duff S, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, Murray P. European Journal of Heart Failure. 2021 Jul;23(7):1122-1130. doi: 10.1002/ejhf.2179. PMID: 33788989

Direct oral anticoagulants versus warfarin in octogenarians with nonvalvular atrial fibrillation: a systematic review and meta-analysis. Bonanad C, Garcia-Blas S, Torres Llergo J, Fernandez-Olmo R, Diez-Villanueva P, Ariza-Sole A, Martinez-Selles M, Raposeiras S, Ayesta A, Bertomeu-Gonzalez V, Tarazona Santabalbina F, Facila L, Vivas D, Gabaldon-Perez A, Bodi V, Nunez J, Cordero A. Journal of Clinical Medicine. 2021 Nov 12;10(22):5268. doi: 10.3390/jcm10225268. PMID: 34830548

Early urinary sodium trajectory and risk of adverse outcomes in acute heart failure and renal dysfunction. De La Espriella Juan R, Nuñez Benito E, Llàcer P, Garcia Blas S, Ventura Haro S, Núñez J, Sánchez R, Facila De La Esperanza R, Vaquer Santamaria J, Bodí Peris V, Santas Olmeda E, Miñana Escriva G, Mollar Fernandez A, Núñez Marín G, Chorro Gascó F, Górriz Teruel J, Sanchis Fores J, Bayés-Genis A, Nuñez Villota J. Revista Espanola de Cardiologia (English ed.). 2021 Jul;74(7):616-623. doi: 10.1016/j.rec.2020.06.004. PMID: 32624444

Effect of beta-blocker withdrawal on functional capacity in heart failure and preserved ejection fraction. Palau P, Seller J, Dominguez E, Sastre C, Ramon JM, Espriella R, Santas E, Minana G, Bodi V, Sanchis J, Valle A, Chorro FJ, Llacer P, Bayes-Genis A, Nunez J. Journal of the American College of Cardiology. 2021 Nov 23;78(21):2042-2056. doi: 10.1016/j.jacc.2021.08.073. PMID: 34794685

Effect of sotagliflozin on total hospitalizations in patients with type 2 diabetes and worsening heart failure: a randomized trial. Szarek M, Bhatt D, Steg P, Cannon C, Leiter L, McGuire D, Lewis J, Riddle M, Voors A, Metra M, Lund L, Komajda M, Testani J, Wilcox C, Ponikowski P, Lopes R, Banks P, Tesfaye E, Ezekowitz J, Verma S, Pitt B, SOLOIST-WHF Comm Investigators. Annals of Internal Medicine. 2021 Aug;174(8):1065-1072. doi: 10.7326/M21-0651. PMID: 34152828

Effects of empagliflozin on CA125 trajectory in patients with chronic congestive heart failure. de la Espriella R, Minana G, Santas E, Nunez G, Lorenzo M, Nunez E, Bayes-Genis A, Nunez J. International Journal of Cardiology. 2021 Sep 15;339:102-105. doi: 10.1016/j.ijcard.2021.06.045. PMID: 34216708

Frailty scales for prognosis assessment of older adult patients after acute myocardial infarction. Garcia-Blas S, Bonanad C, Fernandez-Cisnal A, Sastre-Arbona C, Ruescas-Nicolau M, D’Gregorio J, Valero E, Minana G, Palau P, Tarazona-Santabalbina F, Ros V, Nunez J, Sanchis J. Journal of Clinical Medicine. 2021 Sep 21;10(18):4278. doi: 10.3390/jcm10184278. PMID: 34575389

Head-to-head comparison of contemporary heart failure risk scores. Codina P, Lupon J, Borrellas A, Spitaleri G, Cediel G, Domingo M, Simpson J, Levy WC, Santiago-Vacas E, Zamora E, Buchaca D, Subirana I, Santesmases J, Diez-Quevedo C, Troya MI, Boldo M, Altmir S, Alonso N, Gonzalez B, Rivas C, Nunez J, McMurray J, Bayes-Genis A. European Journal of Heart Failure. 2021 Dec;23(12):2035-2044. doi: 10.1002/ejhf.2352. PMID: 34558158

Heart failure with preserved ejection fraction: an urgent need for precision medicine. Minana, G, Nunez J. Journal of Clinical Medicine. 2021 Apr 21;10(9):1801. doi: 10.3390/jcm10091801. PMID: 33918988

Homocysteine and long-term recurrent infarction following an acute coronary síndrome. Miñana Escriva G, Gil Cayuela C, Facila De La Esperanza R, Bodí Peris V, Valero Picher E, Mollar Fernandez A, Marco M, Garcia-Ballester T, Zorio B, Marti-Cervera J, Nuñez Benito E, Chorro Gascó F, Sanchis Fores J, Nuñez Villota J. Cardiology Journal. 2021;28(4):598-606. doi: 10.5603/CJ.a2020.0170. PMID: 33346372

Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients. Rumiz E, Cubillos A, Vilar J, Garcia P, Berenguer A, Facila L, Valero E, Vidal V, Morell S, Nunez J. Scientific Reports. 2021 Aug 16;11(1):16597. doi: 10.1038/s41598-021-95897-5. PMID: 34400680

Iron deficiency testing and treatment in heart failure: the eyes are useless when the mind is blind. Minana G, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2021 Nov;23(11):1855-1857. doi: 10.1002/ejhf.2365. PMID: 34655260

Is acute heart failure a distinctive disorder? An analysis from BIOSTAT-CHF. Davison B, Senger S, Sama I, Koch G, Mebazaa A, Dickstein K, Samani N, Metra M, Anker S, Cleland J, Ng L, Mordi I, Zannad F, Filippatos G, Hillege H, Ponikowski P, van Veldhuisen D, Lang C, van der Meer P, Nunez J, Bayes-Genis A, Edwards C, Voors A, Cotter G. European Journal of Heart Failure. 2021 Jan;23(1):43-57. doi: 10.1002/ejhf.2077. PMID: 33340221

Long-term outcome of patients with NSTEMI and nonobstructive coronary arteries by different angiographic subtypes. Garcia-Blas S, Gonzalez D’ Gregorio J, Bonanad C, Fernandez-Cisnal A, Valero E, Minana G, Mollar A, Nunez J, Sanchis J. Revista Espanola de Cardiologia. 2021 Nov;74(11):919-926. doi: 10.1016/j.rec.2020.10.008. PMID: 33349589

Long-term prognostic implications of revascularization in patients with known or suspected chronic coronary syndromes without ischemia in vasodilator stress cardiovascular magnetic resonance. Minana G, Nunez J, Marcos-Garces V, Gavara J, Rios-Navarro C, Bodi V. International Journal of Cardiology. 2021 Jul 15;335:15-18. doi: 10.1016/j.ijcard.2021.04.037. PMID: 33895211

Long-Term Prognostic Value of Cognitive Impairment on Top of Frailty in Older Adults after Acute Coronary Syndrome. Sanchis J, Bonanad C, Garcia-Blas S, Ruiz V, Fernandez-Cisnal A, Sastre C, Ruescas A, Valero E, Gonzalez J, Mollar A, Minana G, Nunez J. Journal of Clinical Medicine. 2021 Jan 24;10(3):444. doi: 10.3390/jcm10030444. PMID: 33498816

Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications. GAVARA DOÑATE J, Rodriguez-Palomares J, Rios Navarro C, Valente F, Monmeneu J, Lopez-Lereu M, Ferreira-Gonzalez I, Garcia Del Blanco B, Otaegui I, Canoves Femenia J, De Dios Lluch E, Pérez Solé N, Racugno P, Bonanad Lozano C, Miñana Escriva G, Marcos Garcés V, Barrabes J, Evangelista A, Moratal D, Bayes-Genis A, Nuñez Villota J, Chorro Gascó F, Bodí Peris V. The International Journal Of Cardiovascular Imaging. 2021 Jan;37(1):241-253. doi: 10.1007/s10554-020-01890-w. PMID: 32488452

Lung ultrasound in outpatients with heart failure: the wet-to-dry HF study. Domingo M, Lupon J, Girerd N, Conangla L, de Antonio M, Moliner P, Santiago-Vacas E, Codina P, Cediel G, Spitaleri G, Gonzalez B, Diaz V, Rivas C, Velayos P, Nunez J, Bayes-Genis A. ESC Heart Failure. 2021 Dec;8(6):4506-4516. doi: 10.1002/ehf2.13660. PMID: 34725962

Matrix metalloproteinase-12 cleaved fragment of titin as a predictor of functional capacity in patients with heart failure and preserved ejection fraction. Palau Sampio P, Reese-Petersen A, Dominguez E, Ramón Ferrandis J, Lopez L, Mollar Fernandez A, Chorro Gascó F, Sanchis Fores J, Nuñez Villota J. Scandinavian Cardiovascular Journal. 2021 Feb;55(1):9-14. doi: 10.1080/14017431.2020.1831052. PMID: 33030056

Mid-term Prognostic Implication of hospitalized COVID-19 patients with Prior Heart Failure diagnosis. Llacer P, Manzano L, Fernandez C, Moreno M, Nunez J. European Journal of Internal Medicine. 2021 Jun;88:136-138. doi: 10.1016/j.ejim.2021.02.013. PMID: 33676804

Mortality trends in an ambulatory multidisciplinary heart failure unit from 2001 to 2018. Spitaleri G, Lupon J, Domingo M, Santiago-Vacas E, Codina P, Zamora E, Cediel G, Santesmases J, Diez-Quevedo C, Troya M, Boldo M, Altmir S, Alonso N, Gonzalez B, Nunez J, Bayes-Genis A. Scientific reports. 2021 Jan 12;11(1):732. doi: 10.1038/s41598-020-79926-3. PMID: 33436787

Potential Utility of Cardio-Renal Biomarkers For Prediction and Prognostication of Worsening Renal Function in Acute Heart Failure: Cardio-Renal Biomarkers and WRF in AHF. Horiuchi Y, Wettersten N, van Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, Barnett O, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, Murray P. Journal of Cardiac Failure. 2021 May;27(5):533-541. doi: 10.1016/j.cardfail.2020.11.025. PMID: 33296713

Predictive value of pro-BNP for heart failure readmission after an acute coronary syndrome. Cordero A, Rey-Ranal E, Moreno M, Escribano D, Moreno-Arribas J, Quintanilla M, Zuazola P, Nunez J, Bertomeu-Gonzalez V. Journal of Clinical Medicine. 2021 Apr 13;10(8):1653. doi: 10.3390/jcm10081653. PMID: 33924437

Prognosis impact of diabetes in elderly women and men with non-ST elevation acute coronary syndrome. Diez-Villanueva P, Garcia-Acuna JM, Raposeiras-Roubin S, Barrabes JA, Cordero A, Martinez-Selles M, Bardaji A, Marin F, Ruiz-Nodar JM, Vicente-Ibarra N, Alonso Salinas GL, Cid-Alvarez B, Abu Assi E, Formiga F, Nunez J, Nunez E, Ariza-Sole A, Sanchis J. Journal of Clinical Medicine. 2021 Sep 26;10(19):4403. doi: 10.3390/jcm10194403. PMID: 34640420

Prognostic value of indexed pulmonary artery diameter assessed by cardiac magnetic resonance imaging in patients with acute heart failure. Nuñez Villota J, Merenciano González H, Santas Olmeda E, Lopez Lereu M, Monmeneu Menadas J, Valero Picher E. Revista Espanola De Cardiologia (english Ed.). 2021 Mar;74(3):267-269. doi: 10.1016/j.rec.2020.06.039. PMID: 32978097

Quantification and treatment of congestion in heart failure: a clinical and pathophysiological overview. de la Espriella R, Santas E, Zegri Reiriz I, Gorriz J, Cobo Marcos M, Nunez J. Nefrologia. 2021 Jul 18:S0211-6995(21)00114-4. doi: 10.1016/j.nefro.2021.04.006. PMID: 34289940

Randomized Comparison of Exercise Intervention Versus Usual Care in Older Adult Patients with Frailty After Acute Myocardial Infarction. Sanchis J, Sastre C, Ruescas A, Ruiz V, Valero E, Bonanad C, Garcia-Blas S, Fernandez-Cisnal A, Gonzalez J, Minana G, Nunez J. American Journal of Medicine. 2021 Mar;134(3):383-390.e2. doi: 10.1016/j.amjmed.2020.09.019. PMID: 33228950

Relation of Decongestion and Time to Diuretics to Biomarker Changes and Outcomes in Acute Heart Failure. Horiuchi Y, Wettersten N, van Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, Barnett O, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, Murray P. American Journal of Cardiology. 2021 May 15;147:70-79. doi: 10.1016/j.amjcard.2021.01.040. PMID: 33617811

Right heart dysfunction and readmission risk across left ventricular ejection fraction status in patients with acute heart failure. Santas E, Minana G, Palau P, De La Espriella R, Lorenzo M, Nunez G, Sanchis J, Chorro FJ, Bayes-Genis A, Nunez J. Journal of Cardiac Failure. 2021 Oct;27(10):1090-1098. doi: 10.1016/j.cardfail.2021.06.020. PMID: 34273477

Sex differences on new-onset heart failure in patients with known or suspected coronary artery disease. Nunez J, Lorenzo M, Minana G, Palau P, Monmeneu JV, Lopez-Lereu MP, Gavara J, Marcos-Garces V, Rios-Navarro C, Perez N, de Dios E, Nunez E, Sanchis J, Chorro FJ, Bayes-Genis A, Bodi V. European Journal of Preventive Cardiology. 2021 Dec 29;28(15):1711-1719. doi: 10.1093/eurjpc/zwab078. PMID: 33970216

Sotagliflozin in patients with diabetes and recent worsening heart failure. Bhatt D, Szarek M, Steg P, Cannon C, Leiter L, McGuire D, Lewis J, Riddle M, Voors A, Metra M, Lund L, Komajda M, Testani J, Wilcox C, Ponikowski P, Lopes R, Verma S, Lapuerta P, Pitt B, SOLOIST-WHF Trial Investigators. New England Journal of Medicine. 2021 Jan 14;384(2):117-128. doi: 10.1056/NEJMoa2030183. PMID: 33200892

sST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction. De La Espriella Juan R, Bayes-Genis A, Revuelta E, Miñana Escriva G, Santas Olmeda E, Llacer P, Garcia Blas S, Fernández Cisnal A, Bonanad Lozano C, Ventura S, Sanchez R, Bodí Peris V, Cordero A, Facila De La Esperanza R, Mollar Fernandez A, Sanchis Fores J, Improve-Hf Investigators, Nuñez Villota J. Journal Of Cardiac Failure. 2021 Apr;27(4):427-434. doi: 10.1016/j.cardfail.2020.10.002. PMID: 33038531

Supervised Analysis for Phenotype Identification: The Case of Heart Failure Ejection Fraction Class. Lopez C, Holgado JL, Cortes R, Sauri I, Fernandez A, Calderon JM, Nuñez J, Redon J. Bioengineering. 2021 Jun 21;8(6):85. doi: 10.3390/bioengineering8060085. PMID: 34205745

The ‘Peptide for Life’ Initiative: a call for action to provide equal access to the use of natriuretic peptides in the diagnosis of acute heart failure across Europe. Bayes-Genis A, Januzzi J, Richards A, Arfsten H, de Boer R, Emdin M, Gonzalez A, Jaarsma T, Jhund P, Mueller C, Nunez J, Rossignol P, Milinkovic I, Rosano G, Coats A, Seferovic P. European Journal of Heart Failure. 2021 Sep;23(9):1432-1436. doi: 10.1002/ejhf.2293. PMID: 34231321

CA125 outperforms NT-proBNP in acute heart failure with severe tricuspid regurgitation. Soler Costa M, Miñana Escriva G, Santas Olmeda E, Nuñez Benito E, De La Espriella Juan R, Valero Picher E, Bodí Peris V, Chorro Gascó F, Fernández Cisnal A, D’ascoli G, Marti-Cervera J, Sanchis Fores J, Bayes-Genis A, Nuñez Villota J. International Journal of Cardiology. 2020 Jun 1;308:54-59. doi: 10.1016/j.ijcard.2020.03.027. PMID: 32209267

Chronotropic Incompetence Predicts Distance Walked in Six-Minute Walk Test in Heart Failure with Preserved Ejection Fraction. Palau Sampio P, Dominguez E, Seller J, Sastre Arbona C, Bayes-Genis A, Nuñez Villota J. Journal of Cardiac Failure. 2020 Nov;26(11):1024-1025. doi: 10.1016/j.cardfail.2020.08.011. PMID:32846204

Clinical profile and 1-year clinical outcomes of super elderly patients admitted with acute heart failure. Lorenzo Hernández M, De La Espriella Juan R, Miñana Escriva G, Núñez Marín G, Santas Olmeda E, Nuñez Benito E, Heredia Cambra R, Mollar Fernandez A, Civera Gómez J, Villaescusa Capilla M, Sastre Arbona C, Conesa Bona A, Bonanad Lozano C, Bayes-Genis A, Nuñez Villota J. European Journal of Internal Medicine. 2020 Nov;81:78-82. doi: 10.1016/j.ejim.2020.05.017. PMID: 32553586

Clinical Role of CA125 in WorseningHeartFailure: A BIOSTAT-CHF Study Subanalysis. NUÑEZ VILLOTA J, Bayes-Genis A, Revuelta-Lopez E, Ter Maaten J, Miñana Escriva G, Barallat J, Cserkoova A, Bodí Peris V, Fernández Cisnal A, Nuñez Benito E, Sanchis Fores J, Lang C, Ng L, Metra M, Voors A. JACC. Heart failure. 2020 May;8(5):386-397. doi: 10.1016/j.jchf.2019.12.005. PMID: 32171764

Differential prognostic impact of type 2 diabetes mellitus in women and men with heart failure with preserved ejection fraction. Palau P, Bertomeu-González V, Sanchis J, Soler M, de la Espriella R, Domínguez E, Santas E, Núñez E, Chorro FJ, Miñana G, Bayés-Genís A, Núñez J. Revista Espanola de Cardiologia (english Ed.). 2020 Jun;73(6):463-470. doi: 10.1016/j.rec.2019.09.002. PMID: 31629690

Early Spot Urinary Sodium and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction. Miñana Escriva G, Llacer P, Sanchis I, Garcia Blas S, Bonanad Lozano C, Ventura S, Sanchez R, De La Espriella Juan R, Bodí Peris V, Facila De La Esperanza R, Mollar Fernandez A, Sanchis Fores J, Bayes-Genis A, Chorro Gascó F, Nuñez Villota J. CardioRenal Medicine. 2020;10(5):362-372. doi: 10.1159/000508178. PMID: 32721973

Effect of insulin on readmission for heart failure following a hospitalization for acute heart failure. Bertomeu-Gonzalez V, Facila L, Palau Sampio P, Miñana Escriva G, Núñez Marín G, De La Espriella Juan R, Santas Olmeda E, Nunez E, Bodí Peris V, Chorro Gascó F, Cordero A, Sanchis Fores J, Lupon J, Bayes-Genis A, Nuñez Villota J. Esc Heart Failure. 2020 Aug 13;7(6):3320-3328. doi: 10.1002/ehf2.12944. PMID: 32790113

Effects of the dual sodium-glucose linked transporter inhibitor, licogliflozin vs placebo or empagliflozin in patients with type 2 diabetes and heart failure. de Boer R, Nuñez Villota J, Kozlovski P, Wang Y, Proot P, Keefe D. British Journal of Clinical Pharmacology. 2020 Jul;86(7):1346-1356. doi: 10.1111/bcp.14248. PMID: 32068914

Efficacy and safety of combined neprilysin and RAS inhibition in heart failure: Let’s leave the doubts behind. De La Espriella Juan R, Bayes-Genis A, Nuñez Villota J. International Journal of Cardiology. 2020 Feb 1;300:198-200. doi: 10.1016/j.ijcard.2019.09.023. PMID: 31748185

Ejection Fraction by Echocardiography for a Selective Use of Magnetic Resonance After Infarction. Marcos-Garces V, Gavara J, Lopez-Lereu M, Monmeneu J, Rios-Navarro C, de Dios E, Perez N, Canoves J, Gonzalez J, Minana G, Nunez J, de la Espriella R, Santas E, Moratal D, Chorro F, Valente F, Lorenzatti D, Rodriguez-Palomares J, Ortiz-Perez J, Bodi V. Circulation. Cardiovascular Imaging. 2020 Dec;13(12):e011491. doi: 10.1161/CIRCIMAGING.120.011491. PMID: 33297764

Factors associated with plasma antigen carbohydrate 125 and amino-terminal pro-B-type natriuretic peptide concentrations in acute heart failure. Miñana Escriva G, De La Espriella Juan R, Mollar Fernandez A, Santas Olmeda E, Nuñez Benito E, Valero Picher E, Bodí Peris V, Chorro Gascó F, Fernández Cisnal A, Marti-Cervera J, Sanchis Fores J, Bayes Genis A, Nuñez Villota J. European Heart Journal-Acute Cardiovascular Care. 2020 Aug;9(5):437-447. doi: 10.1177/2048872620908033. PMID: 32129669

Impact of Acute Hemoglobin Falls in Heart Failure Patients: A Population Study. López Zumel M, Holgado Sánchez J, Ferrandez Izquierdo A, Saurí Ferrer M, Uso Talamantes R, Trillo Mata J, Vela Bernal S, Bea Serrano C, Nuñez Villota J, Ferrer Albero A, Gamez Payá J, Ruiz Hernandez A, Redón Mas J. Journal of Clinical Medicine. 2020 Jun 15;9(6):1869. doi: 10.3390/jcm9061869. PMID: 32549339

Impact of pre-hospital renal function on the detection of acute kidney injury in acute decompensated heart failure. Sanchez-Serna J, Hernandez-Vicente A, Garrido-Bravo I, Pastor-Perez F, Noguera-Velasco J, Casas-Pina T, Rodriguez-Serrano A, Nuñez Villota J, Pascual-Figal D. European Journal of Internal Medicine. 2020 Jul;77:66-72. doi: 10.1016/j.ejim.2020.02.028. PMID: 32127300

Lipoprotein(a) and long-term recurrent infarction after an episode of ST-segment elevation acute myocardial infarction. Miñana Escriva G, Gil-Cayuela C, Bodí Peris V, De La Espriella Juan R, Valero Picher E, Mollar Fernandez A, Marco M, Garcia-Ballester T, Zorio B, Fernández Cisnal A, Chorro Gascó F, Sanchis Fores J, Nuñez Villota J. Coronary Artery Disease. 2020 Jun;31(4):378-384. doi: 10.1097/MCA.0000000000000852. PMID: 32040026

Long-term LVEF trajectories in patients with type 2 diabetes and heart failure: diabetic cardiomyopathy may underlie functional decline. Julian M, Alonso N, Lupon J, Gavidia-Bovadilla G, Ferrer E, de Antonio M, Lopez-Ayerbe J, Domingo M, Santiago-Vacas E, Zamora E, Codina P, Moliner P, Nuñez Villota J, Santesmases J, Puig-Domingo M, Bayes-Genis A. Cardiovascular Diabetology. 2020 Mar 23;19(1):38. doi: 10.1186/s12933-020-01011-w. PMID: 32293458

Neprilysin inhibition, endorphin dynamics, and early symptomatic improvement in heart failure: a pilot study. Revuelta-Lopez E, Nuñez Villota J, Gastelurrutia P, Cediel G, Januzzi J, Ibrahim N, Emdin M, VanKimmenade R, Pascual-Figal D, Nunez E, Gommans F, Lupon J, Bayes-Genis A. Esc Heart Failure. 2020 Apr;7(2):559-566. doi: 10.1002/ehf2.12607. PMID: 32045114

Noninvasive Imaging Estimation of Myocardial Iron Repletion Following Administration of Intravenous Iron: The Myocardial-IRON Trial. Nuñez Villota J, Miñana Escriva G, Cardells Beltran I, Palau P, Llacer P, Facila L, Almenar L, Lopez Lereu M, Monmeneu Menadas J, Amiguet Comins M, González D’gregorio J, Serrano Alcalá A, Montagud V, Lopez-Vilella R, Valero Picher E, Garcia Blas S, Bodí Peris V, De La Espriella Juan R, Lupon J, Navarro Perez J, Górriz Teruel J, Sanchis Fores J, Chorro Gascó F, Comin-Colet J, Bayes Genis A, Myocardial-IRON Investigators. Journal of the American Heart Association. 2020 Feb 18;9(4):e014254. doi: 10.1161/JAHA.119.014254. PMID: 32067585

Pulmonary hypertension and right ventricular dysfunction in heart failure: prognosis and 15-year prospective longitudinal trajectories in survivors. Santiago-Vacas E, Lupon J, Gavidia-Bovadilla G, Gual-Capllonch F, de Antonio M, Domingo M, Nuñez Villota J, Zamora E, Teis A, Moliner P, Codina P, Santesmases J, Bayes-Genis A. European Journal of Heart Failure. 2020 Jul;22(7):1214-1225. doi: 10.1002/ejhf.1862. PMID: 32452102

Refractory congestive heart failure: when the solution is outside the heart. Pernias Escrig V, Gonzalez Rico M, Miñana Escriva G, Górriz Teruel J, Juan Garcia I, Chorro Gascó F, Sanchis Fores J, Nuñez Villota J. Esc Heart Failure. 2020 Feb;7(1):311-314. doi: 10.1002/ehf2.12554. PMID: 31833193

Rehospitalization burden and morbidity risk in patients with heart failure with mid-range ejection fraction. Santas Olmeda E, De La Espriella Juan R, Palau P, Miñana Escriva G, Amiguet Comins M, Sanchis Fores J, Lupon J, Bayes Genis A, Chorro Gascó F, Nuñez Villota J. Esc Heart Failure. 2020 Jun;7(3):1007-1014. doi: 10.1002/ehf2.12683. PMID: 32212327

Relation of Low Lymphocyte Count to Frailty and its 11) Usefulness as a Prognostic Biomarker in Patients >65 Years of Age With Acute Coronary Syndrome. Nuñez Villota J, Sastre Arbona C, D’ascoli G, Ruiz Ros V, Bonanad Lozano C, Miñana Escriva G, Valero Picher E, Garcia Blas S, Mollar Fernandez A, Villaescusa Capilla M, Arantzazu Ruescas-Nicolau M, Nuñez Benito E, Formiga F, Chorro Gascó F, Sanchis Fores J. American Journal of Cardiology. 2020 Apr 1;125(7):1033-1038. doi: 10.1016/j.amjcard.2020.01.006. PMID: 31959430

Renal function dynamics following co-administration of sacubitril/valsartan and empagliflozin in patients with heart failure and type 2 diabetes. De La Espriella Juan R, Bayes-Genis A, Morillas H, Bravo R, Vidal V, Nunez E, Santas Olmeda E, Miñana Escriva G, Sanchis Fores J, Facila L, Torres F, Górriz Teruel J, Valle A, Nuñez Villota J. Esc Heart Failure. 2020 Sep 22;7(6):3792-3800. doi: 10.1002/ehf2.12965. PMID: 32964683

Right Ventricular Dysfunction Staging System for Mortality Risk Stratification in Heart Failure with Preserved Ejection Fraction. Santas Olmeda E, De La Espriella Juan R, Chorro Gascó F, Palau P, Miñana Escriva G, Heredia Cambra R, Amiguet Comins M, Merenciano González H, Sanchis Fores J, Lupon J, Bayes Genis A, Nuñez Villota J. Journal of Clinical Medicine. 2020 Mar 18;9(3):831. doi: 10.3390/jcm9030831. PMID: 32197527

Role of PCSK9 in the course of ejection fraction change after ST-segment elevation myocardial infarction: a pilot study. Miñana Escriva G, Nuñez Villota J, Bayes Genis A, Revuelta-Lopez E, Rios Navarro C, Nuñez Benito E, Chorro Gascó F, Lopez Lereu M, Monmeneu Menadas J, Lupon J, Sanchis Fores J, Bodí Peris V. Esc Heart Failure. 2020 Feb;7(1):117-122. doi: 10.1002/ehf2.12533. PMID: 31903686

Sacubitril/Valsartan as Antifibrotic Drug Rejuvenating the Fibrosed HFpEF Heart. Bayes Genis A, Nunez J, Lupon J. Journal of the American College of Cardiology.2020 Aug 4;76(5):515-517. doi: 10.1016/j.jacc.2020.06.016. PMID: 32731929

Sex-differential effect of frailty on long-termmortality in elderly patients after an acute coronary síndrome. Nuñez Villota J, Palau P, Sastre Arbona C, D’ascoli G, Ruiz Ros V, Bonanad Lozano C, Miñana Escriva G, Nunez E, Sanchis Fores J. International Journal of Cardiology. 2020 Mar 1;302:30-33. doi: 10.1016/j.ijcard.2019.12.068. PMID: 31924393

Short-term changes in left and right systolic function following ferric carboxymaltose: a substudy of the Myocardial-IRON trial. Santas Olmeda E, Miñana Escriva G, Cardells I, Palau Sampio P, Llàcer P, Facila De La Esperanza R, Almenar L, López-Lereu M, Monmeneu J, Sanchis Fores J, Maceira A, Bayés-Genís A, Nuñez Villota J, Myocardial-IRON Investigators. Esc Heart Failure. 2020 Oct 11;7(6):4222-4230. doi: 10.1002/ehf2.13053. PMID: 33040491

Short-term prognostic implications of serum and urine neutrophil gelatinase-associated lipocalin in acute heart failure: findings from the AKINESIS study. Wettersten N, Horiuchi Y, van Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueeller G, Birkhahn R, Taub P, Vilke G, Barnett O, McDonald K, Mahon N, Nuñez Villota J, Briguori C, Passino C, Maisel A, Murray P. European Journal of Heart Failure. 2020 Feb;22(2):251-263. doi: 10.1002/ejhf.1642. PMID: 31863682

Sodium-glucose cotransporter 2 inhibition: towards an indication to treat diabetic kidney disease. Górriz Teruel J, NAVARRO GONZALEZ J, Ortiz A, Vergara A, Nuñez Villota J, Jacobs-Cacha C, Martinez-Castelao A, Jose Soler M. Nephrology, dialysis, transplantation. 2020 Jan 1;35(Suppl 1):i13-i23. doi: 10.1093/ndt/gfz237. PMID: 32003834

Study design of Heart failure Events reduction with Remote Monitoring and eHealth Support (HERMeS). Yun S, Enjuanes C, Calero E, Hidalgo E, Cobo M, Llacer P, Garcia-Pinilla J, Gonzalez-Franco A, Nuñez Villota J, Morales-Rull J, Beltran P, Delso C, Freixa-Pamias R, Moliner P, Corbella X, Comin-Colet J, HERMeS trial investigators group. Esc Heart Failure. 2020 Sep 17;7(6):4448-4457. doi: 10.1002/ehf2.12962. PMID: 32940428

The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects. Bonanad Lozano C, Garcia Blas S, Tarazona-Santabalbina F, Sanchis Fores J, Bertomeu-Gonzalez V, Facila De La Esperanza R, Ariza A, Nuñez Villota J, Cordero A. Journal of the American Medical Directors Association. 2020 Jul;21(7):915-918. doi: 10.1016/j.jamda.2020.05.045. PMID: 32674819

The emerging role of carbohydrate antigen 125 in heart failure. Santas Olmeda E, Palau P, Bayes Genis A, Nuñez Villota J. Biomarkers in Medicine. 2020 Mar;14(4):249-252. doi: 10.2217/bmm-2019-0470. PMID: 32125176

The pre-HFpEF stage: a new entity that requires proper phenotyping for better management. Bayes-Genis A, Pascual-Figal D, Nuñez Villota J. European Journal of Preventive Cardiology. 2020 Feb 4;2047487320902326. doi: 10.1177/2047487320902326. PMID: 32019372

Transitioning from Preclinical to Clinical Heart Failure with Preserved Ejection Fraction: A Mechanistic Approach. Bayes-Genis A, Bisbal F, Nuñez Villota J, Santas Olmeda E, Lupon J, Rossignol P, Paulus W. Journal of Clinical Medicine. 2020 Apr 13;9(4):1110. doi: 10.3390/jcm9041110. PMID: 32294958

Trefoil factor-3 and galectin-4 as new candidates for prognostic biomarkers in ST-segment elevation myocardial infarction. Fernández Cisnal A, García-Blas S, Valero E, Miñana G, Núñez J, Sanchis Forés J. Revista Espanola de Cardiologia (english Ed.). 2020 May;73(5):418-420. doi: 10.1016/j.rec.2019.10.008. PMID: 31761572

Undetectable high-sensitivity troponin in combination with clinical assessment for risk stratification of patients with chest pain and normal troponin at hospital arrival. Sanchis Fores J, Valero Picher E, Garcia Blas S, Barba Serrano E, Pernias Escrig V, Miñana Escriva G, Brasó Aznar J, Fernández Cisnal A, González D’gregorio J, Noceda Bermejo J, Carratalá Calvo A, Chorro Gascó F, Nuñez Villota J, Pickering J. European Heart Journal-Acute Cardiovascular Care. 2020 Sep;9(6):567-575. doi: 10.1177/2048872620907539. PMID: 32067483

Urine: an overlooked biomedium in heart failure?. De La Espriella Juan R, Bayes-Genis A, Nunez E, Nuñez Villota J. Biomarkers in Medicine. 2020 Feb;14(3):165-168. doi: 10.2217/bmm-2019-0433. PMID: 32057256

Vasodilator Stress CMR and All-Cause Mortality in Stable Ischemic Heart Disease: A Large Retrospective Registry. Marcos Garcés V, Gavara Doñate J, Monmeneu Menadas J, Lopez-Lereu M, Bosch M, Merlos P, Pérez Solé N, Rios Navarro C, De Dios Lluch E, Bonanad Lozano C, Racugno P, Bellver Navarro A, Ventura Perez B, Aguilar Botella J, Ventura Haro S, Mainar Latorre L, Canoves Femenia J, Pellicer Bañuls M, Moratal Perez D, Miñana Escriva G, Nuñez Villota J, Chorro Gascó F, Bodí Peris V- Jacc-Cardiovascular Imaging. 2020 Aug;13(8):1674-1686. doi: 10.1016/j.jcmg.2020.02.027. PMID: 32682717

Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction. Armstrong P, Pieske B, Anstrom K, Ezekowitz J, Hernandez A, Butler J, Lam C, Ponikowski P, Voors A, Jia G, McNulty S, Patel M, Roessig L, Koglin J, O’Connor C, Nuñez Villota J, VICTORIA Study Group. New England Journal of Medicine. 2020 May 14;382(20):1883-1893. doi: 10.1056/NEJMoa1915928. PMID: 32222134