Dra. Empar Lurbe i Ferrer

Investigador Principal
Grupo de Investigación para la Prevención del Riesgo Cardiovascular en Niños y Adolescentes

Presentación

Empar Lurbe, Licenciada en Medicina por la Universidad de Valencia, Research Fellow en Nefrología e Hipertensión por la Universidad de Northwestern en Chicago, USA. Especialista en Pediatría y Nefrología, Catedrática de Pediatría, Jefa de Servicio de Pediatría del Consorcio Hospital General Universitario de Valencia, Jefa de Grupo del CIBER de Fisiopatología de Obesidad y Nutrición del Instituto de Salud Carlos III. Vicepresidenta de la Sociedad Europea de Hipertensión y miembro del Council de Hipertensión de la Sociedad Europea de Cardiología.

Las líneas de investigación se centran en los orígenes de la enfermedad cardiometabólica, obesidad infantil e hipertensión arterial, así como en el desarrollo y aplicación de nuevas tecnologías dirigidas al bienestar del niño y la familia. Coordinadora de las primeras Guías Europeas de Hipertensión Arterial en Niños y Adolescentes 2009 y su actualización en 2016. Investigadora en proyectos de caracteres competitivos tanto nacionales como internacionales. Coordinadora de Comisiones Técnicas del Instituto de Salud Carlos III (2013-2018). Chair de la COST Action (European Cooperation in Science and Technology) del Proyecto: “Network for blood pressure research in children and adolescents (2020-2025) siendo 27 los países participantes.

La investigación desarrollada ha dado lugar a numerosos artículos internacionales y nacionales, capítulos en libros y editora de tratados de hipertensión en niños y adolescentes. Editora Jefa de Anales de Pediatría (2013-2017), Órgano oficial de la Asociación Española de Pediatría, así como miembro del Comité Editorial de revistas internacionales en las áreas de Pediatría e Hipertensión.
Premio Talal Zein de la Sociedad Europea de Hipertensión (2011), premio 2021 ISH Honour for Senior Women Researchers de la Sociedad Internacional de Hipertensión, premio 2022 WHL Claude Lenfant Excellence Award in Population Hypertension Control de la Liga Mundial de Hipertensión y Miembro de Honor de la Asociación Española de Pediatría, y de las Sociedades Española, Italiana y Húngara de Hipertensión.

Dra. Empar Lurbe i Ferrer
Investigador
Principal
Dra. Empar Lurbe i Ferrer

empar.lurbe@uv.es

Publicaciones
2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH). Mancia Chairperson G, Kreutz Co-Chair R, Brunstrom M, Burnier M, Grassi G, Januszewicz A, Muiesan M, Tsioufis K, Agabiti-Rosei E, Algharably E, Azizi M, Benetos A, Borghi C, Hitij J, Cifkova R, Coca A, Cornelissen V, Cruickshank K, Cunha P, Danser A, de Pinho R, Delles C, Dominiczak A, Dorobantu M, Doumas M, Fernandez-Alfonso M, Halimi J, Jarai Z, Jelakovic B, Jordan J, Kuznetsova T, Laurent S, Lovic D, Lurbe E, Mahfoud F, Manolis A, Miglinas M, Narkiewicz K, Niiranen T, Palatini P, Parati G, Pathak A, Persu A, Polonia J, Redon J, Sarafidis P, Schmieder R, Spronck B, Stabouli S, Stergiou G, Taddei S, Thomopoulos C, Tomaszewski M, Van de Borne P, Wanner C, Weber T, Williams B, Zhang Z, Kjeldsen S. Journal of Hypertension. 2023 Jun 21. doi: 10.1097/HJH.0000000000003480. PMID: 37345492

Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study. Perez-Gimeno G, Seral-Cortes M, Sabroso-Lasa S, Esteban L, Lurbe E, Beghin L, Gottrand F, Meirhaeghe A, Muntaner M, Kafatos A, Molnar D, Leclercq C, Widhalm K, Kersting M, Nova E, Salazar-Tortosa D, Gonzalez-Gross M, Breidenassel C, Sinningen K, De Ruyter T, Labayen I, Ruperez A, Bueno-Lozano G, Moreno L. Frontiers in Cardiovascular Medicine. 2023 Jun 1;10:1118919. doi: 10.3389/fcvm.2023.1118919. PMID: 37324619

Editorial: Blood pressure in children and adolescents: moving forward. Lurbe E, Fernandez-Aranda F, Wuhl E. Frontiers in Cardiovascular Medicine. 2023 Jan 30;10:1142176. doi: 10.3389/fcvm.2023.1142176. PMID: 36793474

HyperChildNET: a European Network Moving Forward in the Field of Pediatric Hypertension. Lurbe E, Mancia G, Drozdz D, Erdine S, Fernandez-Aranda F, Litwin M, Sinha MD, Simonetti G, Stabouli S, Wuhl E. Hypertension. 2023 Apr;80(4):e71-e73. doi: 10.1161/HYPERTENSIONAHA.123.20080. PMID: 36748460

Impact of maternal weight gain on the newborn metabolome. Guixeres-Esteve T, Ponce-Zanon F, Morales J, Lurbe E, Alvarez-Pitti J, Monleon D. Metabolites. 2023 Apr 15;13(4):561. doi: 10.3390/metabo13040561. PMID: 37110219

Joint statement for assessing and managing high blood pressure in children and adolescents: Chapter 2. How to manage high blood pressure in children and adolescents. Wuhl E, Calpe J, Drozdz D, Erdine S, Fernandez-Aranda F, Hadjipanayis A, Hoyer P, Jankauskiene A, Jimenez-Murcia S, Litwin M, Mancia G, Mazur A, Pall D, Seeman T, Sinha M, Simonetti G, Stabouli S, Lurbe E. Frontiers in Pediatrics. 2023 Apr 12;11:1140617. doi: 10.3389/fped.2023.1140617. PMID: 37124176

Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways. Alba Linares J, Perez R, Tejedor J, Bastante Rodriguez D, Ponce F, Carbonell N, Zafra R, Fernandez A, Fraga M, Lurbe E. Cardiovascular Diabetology. 2023 Mar 4;22(1):44. doi: 10.1186/s12933-023-01774-y. PMID: 36870961

Persistence and determinants of blood pressure phenotypes according to office and ambulatory blood pressure measurements in youth. Martinez F, Redon J, Aguilar F, Calderon JM, Lurbe E. Hypertension Research. 2023 May;46(5):1257-1266. doi: 10.1038/s41440-022-01159-w. PMID: 36635525

Blood pressure measurement in children and adolescents: key element in the evaluation of arterial hypertension. Alvarez J, Aguilar F, Lurbe E. Anales de Pediatria. 2022 Jun;96(6):536.e1-536.e7. doi: 10.1016/j.anpede.2022.04.011. PMID: 35659490

Comparison of validation protocols for blood pressure measuring devices in children and adolescents. Stabouli S, Chainoglou A, Evripidou K, Simao C, Antza C, Petrou P, Hamdani G, Calpe J, Lurbe E. Frontiers in Cardiovascular Medicine. 2022 Nov 23;9:1001878. doi: 10.3389/fcvm.2022.1001878. PMID: 36505363

Hypertension in children and adolescents a consensus document from ESC Council on Hypertension, European Association of Preventive Cardiology, European Association of Cardiovascular Imaging, Association of Cardiovascular Nursing & Allied Professions, ESC Council for Cardiology Practice and Association for European Paediatric and Congenital Cardiology. de Simone G, Mancusi C, Hanssen H, Genovesi S, Lurbe E, Parati G, Sendzikaite S, Valerio G, Di Bonito P, Di Salvo G, Ferrini M, Leeson P, Moons P, Weismann C, Williams B. European Heart Journal. 2022 Sep 14;43(35):3290-3301. doi: 10.1093/eurheartj/ehac328. PMID: 35896123

Insights from matched office and ambulatory blood pressure in youth: clinical relevance. Lurbe E, Redon J, Alvarez J, Grau-Perez M, Martinez F, Mancia G. Hypertension. 2022 Mar 29;101161HYPERTENSIONAHA12218993. doi: 10.1161/HYPERTENSIONAHA.122.18993. PMID: 35345885

Knowledge gaps and future directions in cognitive functions in children and adolescents with primary arterial hypertension: a systematic review. Lucas I, Puteikis K, Sinha M, Litwin M, Merkevicius K, Azukaitis K, Rus R, Pac M, Obrycki L, Bardsen T, Sladowska-Kozlowska J, Sagsak E, Lurbe E, Jimenez-Murcia S, Jankauskiene A, Fernandez-Aranda F. Frontiers in Cardiovascular Medicine. 2022 Oct 20;9:973793. doi: 10.3389/fcvm.2022.973793. PMID: 36337900

Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: meta-analysis and meta-regression. Sinha M, Azukaitis K, Sladowska-Kozlowska J, Bardsen T, Merkevicius K, Sletten I, Obrycki L, Pac M, Fernandez-Aranda F, Bjelakovic B, Jankauskiene A, Litwin M, HyperChildNet Working Grp. Frontiers in Cardiovascular Medicine. 2022 Oct 31;9:993513. doi: 10.3389/fcvm.2022.993513. PMID: 36386367

Uric acid and hypertension: a review of evidence and future perspectives for the management of cardiovascular risk. Borghi C, Agnoletti D, Cicero A, Lurbe E, Virdis A. Hypertension. 2022 Sep;79(9):1927-1936. doi: 10.1161/HYPERTENSIONAHA.122.17956. PMID: 35658505

2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement. Stergiou GS, Palatini P, Parati G, O’Brien E, Januszewicz A, Lurbe E, Persu A, Mancia G, Kreutz R. Journal of Hypertension. 2021 Jul 1;39(7):1293-1302. doi: 10.1097/HJH.0000000000002843. PMID: 33710173

Developmental and early life origins of cardiometabolic risk factors: novel findings and implications. Lurbe E, Ingelfinger J. Hypertension. 2021 Feb;77(2):308-318. doi: 10.1161/HYPERTENSIONAHA.120.14592. PMID: 33390043

European Network for blood pressure research in children and adolescents (COST Action CA 19115). Lurbe E, Fernandez-Aranda F, Wuhl E, en representacion del Consorcio HyperChildNET. Anales de Pediatria. 2021 Jun;94(6):421.e1-421.e4. doi: 10.1016/j.anpedi.2021.01.015. PMID: 33653658

European Network for blood pressure research in children and adolescents (COST Action CA 19115). Lurbe E, Fernandez-Aranda F, Wuhl E, HyperChildNET Consortium. Anales de Pediatria. 2021 Jun;94(6):421.e1-421.e4. doi: 10.1016/j.anpede.2021.01.003. PMID: 34090641

Lifestyle, psychological, socioeconomic and environmental factors and their impact on hypertension during the coronavirus disease 2019 pandemic. Kreutz R, Dobrowolski P, Prejbisz A, Algharably EAEH, Bilo G, Creutzig F, Grassi G, Kotsis V, Lovic D, Lurbe E, Modesti PA, Pappaccogli M, Parati G, Persu A, Polonia J, Rajzer M, de Timary P, Weber T, Weisser B, Tsioufis K, Mancia G, Januszewicz A. Journal of Hypertension. 2021 Jun 1;39(6):1077-1089. doi: 10.1097/HJH.0000000000002770. PMID: 33395152

Obesity and cardiometabolic risk factors: from childhood to adulthood. Drozdz D, Alvarez-Pitti J, Wojcik M, Borghi C, Gabbianelli R, Mazur A, Herceg-Cavrak V, Gonzalez Lopez-Valcarcel B, Brzezinski M, Lurbe E, Wuehl E. Nutrients. 2021 Nov 22;13(11):4176. doi: 10.3390/nu13114176. PMID: 34836431

Obesity and eating disorders in children and adolescents: the bidirectional link. Stabouli S, Erdine S, Suurorg L, Jankauskiene A, Lurbe E. Nutrients. 2021 Nov 29;13(12):4321. doi: 10.3390/nu13124321. PMID: 34959873

Primary hypertension beginning in childhood and risk for future cardiovascular disease. Falkner B, Lurbe E. Journal of Pediatrics. 2021 Nov;238:16-25. doi: 10.1016/j.jpeds.2021.08.008. PMID: 34391765

Scientific mapping of the research output on hypertension in children and adolescents, 2010-2018. Abad-Garcia MF, Gonzalez-Teruel A, Bolanos-Pizarro M, Lurbe I Ferrer E. Journal of Hypertension. 2021 Jun 1;39(6):1070-1076. doi: 10.1097/HJH.0000000000002772. PMID: 33929402

The USPSTF call to inaction on blood pressure screening in children and adolescents. Falkner B, Lurbe E. Pediatric Nephrology. 2021 Jun;36(6):1327-1329. doi: 10.1007/s00467-021-04926-y. PMID: 33449211

Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease. Borghi C, Agabiti-Rosei E, Johnson R, Kielstein J, Lurbe Ferrer E, Mancia G, Redón Mas J, Stack A, Tsioufis K. European Journal of Internal Medicine. 2020 Oct;80:1-11. doi: 10.1016/j.ejim.2020.07.006. PMID: 32739239

Identifying poor cardiorespiratory fitness in overweight and obese children and adolescents by using heart rate variability analysis under resting conditions. Redon Lurbe P, Grassi G, Redón Mas J, Alvarez Pitti J, Lurbe Ferrer E. Blood Pressure. 2020 Feb;29(1):13-20. doi: 10.1080/08037051.2019.1700777. PMID: 31829032

Innovations in Infant Feeding: Future Challenges and Opportunities in Obesity and Cardiometabolic Disease. Alvarez Pitti J, De Blas A, Lurbe Ferrer E. Nutrients. 2020 Nov 14;12(11):3508. doi: 10.3390/nu12113508. PMID: 33202614

Network for blood pressure research in children and adolescents: A Cost Action. Lurbe E, HyperChild NET Network. Journal of Hypertension. 2020 Nov;38(11):2331-2334. doi: 10.1097/HJH.0000000000002639. PMID: 32941203

Nutraceuticals and blood pressure control: a European Society of Hypertension position document. Borghi C, Tsioufis K, Agabiti-Rosei E, Burnier M, Cicero A, Clement D, Coca A, Desideri G, Grassi G, Lovic D, LURBE FERRER E, Kahan T, Kreutz R, Jelakovic B, Polonia J, Redón Mas J, Van De Borne P, Mancia G. Journal of Hypertension. 2020 May;38(5):799-812. doi: 10.1097/HJH.0000000000002353. PMID: 31977574

Primordial Prevention of High Blood Pressure in Childhood An Opportunity Not to be Missed. Falkner B, Lurbe Ferrer E. Hypertension. 2020 May;75(5):1142-1150. doi: 10.1161/HYPERTENSIONAHA.119.14059. PMID: 32223379

Redefining hypertension in children and adolescents: A review of the evidence considered by the European Society of Hypertension and American Academy of Pediatrics guidelines.Stabouli S, Redón Mas J, Lurbe Ferrer E. Journal of Hypertension. 2020 Feb;38(2):196-200. doi: 10.1097/HJH.0000000000002247. PMID: 31584513

Proyectos
Referencia: PI20/00269
Título: Impacto del peso al nacer y el patrón de crecimiento en factores de riesgo cardiometabólico en adolescentes postpuberales: aproximación clínica y molecular
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Empar Lurbe i Ferrer
Duración: 2021 – 2023
Presupuesto: 174.845 €
Referencia: COST Action CA19115
Título: Network for blood pressure research in children and adolescents. HyperChildNET
Entidad Financiadora: European Commision
Investigador principal: Empar Lurbe i Ferrer
Duración: 2020 – 2024
Presupuesto: 700.000 €
Referencia: EAT4HEALTHYLIFE
Título: Obesity and abnormal eating behavior across the lifespan. A cross sectional and longitudinal approach of environmental and neurobiological factors
Entidad Financiadora: Instituto de Salud Carlos III – CIBERObn – Cofinanciado FEDER
Investigador principal: Fernando Fernández Aranda
Duración: 2018 – 2020
Presupuesto: 69.220 €
Referencia: PI17/01517
Título: Programación fetal y desarrollo postnatal en hijos de madres obesas: modulación por la alimentación en el primer año de vida
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Empar Lurbe i Ferrer
Duración: 2018 – 2021
Presupuesto: 170.005 €
Referencia: CB06/03/0039
Título: CIBER de la Obesidad y Nutrición (CIBERobn)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Empar Lurbe i Ferrer
Duración: 2006 –
Presupuesto: 85.000 €
+ Información
2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH). Mancia Chairperson G, Kreutz Co-Chair R, Brunstrom M, Burnier M, Grassi G, Januszewicz A, Muiesan M, Tsioufis K, Agabiti-Rosei E, Algharably E, Azizi M, Benetos A, Borghi C, Hitij J, Cifkova R, Coca A, Cornelissen V, Cruickshank K, Cunha P, Danser A, de Pinho R, Delles C, Dominiczak A, Dorobantu M, Doumas M, Fernandez-Alfonso M, Halimi J, Jarai Z, Jelakovic B, Jordan J, Kuznetsova T, Laurent S, Lovic D, Lurbe E, Mahfoud F, Manolis A, Miglinas M, Narkiewicz K, Niiranen T, Palatini P, Parati G, Pathak A, Persu A, Polonia J, Redon J, Sarafidis P, Schmieder R, Spronck B, Stabouli S, Stergiou G, Taddei S, Thomopoulos C, Tomaszewski M, Van de Borne P, Wanner C, Weber T, Williams B, Zhang Z, Kjeldsen S. Journal of Hypertension. 2023 Jun 21. doi: 10.1097/HJH.0000000000003480. PMID: 37345492

2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement. Stergiou GS, Palatini P, Parati G, O’Brien E, Januszewicz A, Lurbe E, Persu A, Mancia G, Kreutz R. Journal of Hypertension. 2021 Jul 1;39(7):1293-1302. doi: 10.1097/HJH.0000000000002843. PMID: 33710173

Lifestyle, psychological, socioeconomic and environmental factors and their impact on hypertension during the coronavirus disease 2019 pandemic. Kreutz R, Dobrowolski P, Prejbisz A, Algharably EAEH, Bilo G, Creutzig F, Grassi G, Kotsis V, Lovic D, Lurbe E, Modesti PA, Pappaccogli M, Parati G, Persu A, Polonia J, Rajzer M, de Timary P, Weber T, Weisser B, Tsioufis K, Mancia G, Januszewicz A. Journal of Hypertension. 2021 Jun 1;39(6):1077-1089. doi: 10.1097/HJH.0000000000002770. PMID: 33395152

Redefining hypertension in children and adolescents: A review of the evidence considered by the European Society of Hypertension and American Academy of Pediatrics guidelines.Stabouli S, Redón Mas J, Lurbe Ferrer E. Journal of Hypertension. 2020 Feb;38(2):196-200. doi: 10.1097/HJH.0000000000002247. PMID: 31584513

2018 ESC/ESH Guidelines for the management of arterial. Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I. Kardiologia Polska. 2019;77(2):71-159. doi: 10.5603/KP.2019.0018. PMID: 30816983

Impact of ESH and AAP hypertension guidelines for children and adolescents on office and ambulatory blood pressure-based classifications. Lurbe E, Torró I, Álvarez J, Aguilar F, Mancia G, Redon J, Redon P. Journal of Hypertension. 2019 Dec;37(12):2414-2421. doi: 10.1097/HJH.0000000000002229. PMID: 31688292