Dra. Cecilia Martínez Costa

Investigador Principal
Grupo de Investigación de Nutrición pediátrica

Presentación

La Dra. Martínez es Catedrática de Pediatría de la Universidad de Valencia y Jefa del Servicio de Pediatría del Hospital Clínico Universitario de Valencia.

Investigadora principal del Grupo de Investigación en Nutrición Pediátrica de INCLIVA integrado por pediatras, investigadores básicos, enfermeros y nutricionistas. Ha participado en numerosos proyectos de investigación traslacional todos ellos en colaboración con áreas clínicas y básicas. Cuenta con cuatro sexenios de investigación reconocidos por ANECA.

Co-chair del Topic Advisory Group for Nutrition de WHO (World Health Organization) que ha desarrollado la clasificación y terminología de los trastornos nutricionales para la versión 11 de ICD (International Classification of Diseases). Miembro del WHO Guideline Developing Group for Preventing obesity in children and adolescents through appropiate infant and child feeding practices, 2015, siendo la única representante española.

Miembro numerario de los grupos de trabajo de nutrición de las sociedades científicas: SEGHNP (Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica) y SENPE (Sociedad Española de Nutrición Enteral y parenteral) que elaboran las guías de nutrición enteral y parenteral pediátricas. Miembro de ESPGHAN (European Society for Pediatric Gastroenterology, Hepatology and Nutrition).

Dra. Cecilia Martínez Costa
Investigador
Principal
Dra. Cecilia Martínez Costa

cecilia.martinez@uv.es

Publicaciones
Assessment of SARS-CoV-2 neutralizing antibody titers in breastmilk from convalescent and vaccinated mothers. Bauerl C, Zulaica J, Rusu L, Moreno A, Perez-Cano F, Lerin C, Mena-Tudela D, Aguilar-Camprubi L, Parra-Llorca A, Martinez-Costa C, Geller R, Collado M. Iscience. 2023 Jun 16;26(6):106802. doi: 10.1016/j.isci.2023.106802. PMID: 37197591

Differences when classifying small for gestational age preterm infants according to the growth chart applied. Estan Capell J, Alarcon Torres B, Miro Pedro M, Martinez Costa C. American Journal of Perinatology. 2023 Jan 29. doi: 10.1055/s-0043-1761297. PMID: 36709759

Distinct breast milk microbiota, cytokine, and adipokine profiles are associated with infant growth at 12 months: an in vitro host-microbe interaction mechanistic approach. Cortes-Macias E, Selma-Royo M, Rio-Aige K, Bauerl C, Rodriguez-Lagunas M, Martinez-Costa C, Perez-Cano F, Collado M. Food & Function. 2023 Jan 3;14(1):148-159. doi: 10.1039/d2fo02060b. PMID: 36472137

Geographical distribution of risk genotypes in pediatric patients with celiac disease in Spain. Sanchez Valverde F, Martinez Ojinaga E, Donat E, Bodas A, Bandres E, Torres R, Ibanez B, Cilleruelo M, Castillejo G, Perez Solis D, Ochoa C, Eizaguirre F, Garcia S, Garcia J, Barrio J, Vecino R, Miranda M, Juste M, Salazar J, Armas H, Ortigosa L, Urruzuno P, Garcia Z, Balmaseda E, Martinez C, La Orden E, Codoner P, Roca A, Trillo C, Sebastian M, Garcia R, Pena-Quintana L, Barros P, Soria M, Garcia R, Perez-Moneo B, Polanco I, Ribes C, Roman E. Human Immunology. 2023 Apr;84(4):290-295. doi: 10.1016/j.humimm.2023.01.010. PMID: 36858916

Safety and efficacy of a new supplementation protocol in patients with cystic fibrosis and vitamin D deficiency. Mangas Sanchez C, Garriga Garcia M, Serrano Nieto M, Garcia Romero R, Alvarez Beltran M, Crehua Gaudiza E, Vicente Santamaria S, Martinez Costa C, Diaz Martin J, Bousono Garcia C, Gonzalez Jimenez D. Anales de Pediatria. 2023 Apr;98(4):257-266. doi: 10.1016/j.anpede.2023.02.015. PMID: 36932016

Anti-SARS-CoV-2 IgA and IgG in human milk after vaccination is dependent on vaccine type and previous SARS-CoV-2 exposure: a longitudinal study. Selma-Royo M, Bauerl C, Mena-Tudela D, Aguilar-Camprubi L, Perez-Cano FJ, Parra-Llorca A, Lerin C, Martinez-Costa C, Collado MC. Genome Medicine. 2022 Apr 21;14(1):42. doi: 10.1186/s13073-022-01043-9. PMID: 35449030

Breast milk lipidome is associated with maternal diet and infants’ growth. Calvo-Lerma J, Selma-Royo M, Hervas D, Yang B, Intonen L, Gonzalez S, Martinez-Costa C, Linderborg K, Collado M. Frontiers in Nutrition. 2022 Jul 6;9:854786. doi: 10.3389/fnut.2022.854786. PMID: 35873422

Cross-cultural adaptation to Spanish and content validity of three nutritional risk scales. Balaguer Lopez E, Garcia-Molina P, Nunez F, Crehua-Gaudiza E, Montal Navarro M, Pedron Giner C, Vitoria Minana I, Jovani Casano C, Galera Martinez R, Gomez-Lopez L, Rodriguez Martinez G, Martinez-Costa C. Anales de Pediatria. 2022 Jul;97(1):12-21. doi: 10.1016/j.anpede.2022.06.001. PMID: 35729061

Galectins-1,-3 and-9 are present in breast milk and have a role in early life development. Rio-Aige K, Girbal M, Selma-Royo M, Parra-Llorca A, Gonzalez S, Martinez-Costa C, Castell M, Collado M, Perez-Cano F, Rodriguez-Lagunas M. Nutrients. 2022 Oct 17;14(20):4338. doi: 10.3390/nu14204338. PMID: 36297023

Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe. Giuffrida F, Fleith M, Goyer A, Samuel T, Elmelegy-Masserey I, Fontannaz P, Cruz-Hernandez C, Thakkar S, Monnard C, De Castro C, Lavalle L, Rakza T, Agosti M, Al-Jashi I, Pereira A, Costeira M, Marchini G, Vanpee M, Stiris T, Stoicescu S, Silva M, Picaud J, Martinez-Costa C, Domellof M, Billeaud C. European Journal of Nutrition. 2022 Jun;61(4):2167-2182. doi: 10.1007/s00394-021-02788-6. PMID: 35072787

Maternal diet is associated with human milk oligosaccharide profile. Selma-Royo M, Gonzalez S, Gueimonde M, Chang M, Furst A, Martinez-Costa C, Bode L, Collado M. Molecular Nutrition & Food Research. 2022 Aug;66(15):e2200058. doi: 10.1002/mnfr.202200058. PMID: 35612565

Metallomic and untargeted metabolomic signatures of human milk from SARS-CoV-2 Positive mothers. Arias-Borrego A, Soto Cruz FJ, Selma-Royo M, Bäuerl C, García Verdevio E, Pérez-Cano FJ, Lerin C, Velasco López I, Martínez-Costa C, Collado MC, García-Barrera T. Molecular Nutrition & Food Research. 2022 Aug;66(16):e2200071. doi: 10.1002/mnfr.202200071. PMID: 35687731

Mode of neonatal delivery influences the nutrient composition of human milk: results from a multicenter european cohort of lactating women. Samuel T, Thielecke F, Lavalle L, Chen C, Fogel P, Giuffrida F, Dubascoux S, Martinez-Costa C, Haaland K, Marchini G, Agosti M, Rakza T, Costeira M, Picaud J, Billeaud C, Thakkar S. Frontiers in Nutrition. 2022 Apr 6;9:834394. doi: 10.3389/fnut.2022.834394. PMID: 35464009

Persistence of Anti SARS-CoV-2 antibodies in breast milk from infected and vaccinated women after in vitro-simulated gastrointestinal digestion. Calvo-Lerma J, Bueno-Llamoga P, Bauerl C, Cortes-Macias E, Selma-Royo M, Perez-Cano F, Lerin C, Martinez-Costa C, Collado M. Nutrients. 2022 May 19;14(10):2117. doi: 10.3390/nu14102117. PMID: 35631258

RNA viral loads of SARS-CoV-2 Alpha and Delta variants in nasopharyngeal specimens at diagnosis stratified by age, clinical presentation and vaccination status. Costa R, Olea B, Bracho M, Albert E, de Michelena P, Martinez-Costa C, Gonzalez-Candelas F, Navarro D. Journal of Infection. 2022 Apr;84(4):579-613. doi: 10.1016/j.jinf.2021.12.018. PMID: 34953901

SARS-CoV-2 RNA and antibody detection in breast milk from a prospective multicentre study in Spain. Bauerl C, Randazzo W, Sanchez G, Selma-Royo M, Garcia-Verdevio E, Martinez L, Parra-Llorca A, Lerin C, Fumado V, Crovetto F, Crispi F, Perez-Cano F, Rodriguez G, Ruiz-Redondo G, Campoy C, Martinez-Costa C, Collado M, MilkCORONA study team. Archives of Disease in Childhood. Fetal and Neonatal Edition. 2022 Mar;107(2):216-221. doi: 10.1136/archdischild-2021-322463. PMID: 34417223

Spanish National Registry of paediatric coeliac disease: changes in the clinical presentation in the 21st century. Solis D, Pascual M, Sangrador C, Burriel J, Visus F, Arocena F, Calatayud S, Nodal E, Aliaga E, Torres J, de Villasante G, Cid M, Peral R, Lopez R, Ruiz M, Ramos H, Garcia P, Leis R, Alberdi R, Quero J, Romero R, del Clastillo L, Quintana L, Telleria P, Franch P, Casales Z, Mas M, Poblet G, Costa C, Serrano E, Allue I, Koninck C, Riechmann E. Journal of Pediatric Gastroenterology and Nutrition. 2022 Jun 1;74(6):805-811. doi: 10.1097/MPG.0000000000003424. PMID: 35192578

The dietary inflammatory index is associated with subclinical mastitis in lactating European women. Afeiche M, Iroz A, Thielecke F, De Castro A, Lefebvre G, Draper C, Martinez-Costa C, Haaland K, Marchini G, Agosti M, Domellof M, Rakza T, Costeira M, Vanpee M, Billeaud C, Picaud J, Hian D, Liu G, Shivappa N, Hebert J, Samuel T. Nutrients. 2022 Nov 8;14(22):4719. doi: 10.3390/nu14224719. PMID: 36432405

Breastfeeding practices influence the breast milk microbiota depending on pre-gestational maternal bmi and weight gain over pregnancy. Cortes-Macias E, Selma-Royo M, Martinez-Costa C, Collado MC. Nutrients. 2021 Apr 30;13(5):1518. doi: 10.3390/nu13051518. PMID: 33946343

Case report: primary peritonitis as the onset of pediatric Menetrier’s disease. Barres-Fernandez A, Piolatti-Luna A, Breton-Martinez J, Crehua-Gaudiza E, Quinones-Torrelo C, Moscardo-Navarro A, Fuertes-Latasa C, Martinez-Costa C. Frontiers in Pediatrics. 2021 Jan 13;8:589853. doi: 10.3389/fped.2020.589853. PMID: 33520889

Diagnosis of celiac disease in clinical practice: present and future. Crehua-Gaudiza E, Barres Fernandez A, Jovani Casano C, Latorre Tejerina M, Largo Blanco E, Moreno Ruiz M, Berghezan Suarez A, Garcia-Peris M, Gil Piquer R, Coret Sinisterra A, Martinez-Barona S, Salido-Capilla C, Requena Fernandez M, Arcos-Machancoses J, Martinez-Costa C. Anales de Pediatria. 2021 Apr;94(4):223-229. doi: 10.1016/j.anpedi.2020.07.008. PMID: 32891578

Evaluation of a rapid antigen detection test (Panbio (TM) COVID-19 Ag Rapid Test Device) as a point-of-care diagnostic tool for COVID-19 in a pediatric emergency department. Carbonell-Sahuquillo S, Lazaro-Carreno M, Camacho J, Barres-Fernandez A, Albert E, Torres I, Breton-Martinez J, Martinez-Costa C, Navarro D. Journal of Medical Virology. 2021 Dec;93(12):6803-6807. doi: 10.1002/jmv.27220. PMID: 34289136

Home and Ambulatory Artificial Nutrition (NADYA) Group report: home parenteral nutrition in Spain, 2019. Wanden-Berghe C, Virgili Casas N, Cuerda Compes C, et al. Nutricion Hospitalaria. 2021 Dec 9;38(6):1304-1309. doi: 10.20960/nh.03720. PMID: 34670394

Human milk oligosaccharides, infant growth, and adiposity over the first 4 months of lactation. Binia A, Lavalle L, Chen C, Austin S, Agosti M, Al-Jashi I, Pereira A, Costeira M, Silva M, Marchini G, Martinez-Costa C, Stiris T, Stoicescu S, Vanpee M, Rakza T, Billeaud C, Picaud J, Domellof M, Adams R, Castaneda-Gutierrez E, Sprenger N. Pediatric Research. 2021 Sep;90(3):684-693. doi: 10.1038/s41390-020-01328-y. PMID: 33446921

Initial viral load and decay kinetics of SARS-CoV-2 lineage B.1.1.7 in the upper respiratory tract of adults and children. Costa R, Bueno F, Gimenez E, Bracho A, Albert E, Carretero D, de Michelena P, Martinez-Costa C, Gonzalez-Candelas F, Navarro D. Journal of Infection. 2021 Oct;83(4):496-522. doi: 10.1016/j.jinf.2021.08.015. PMID: 34390756

Levels of predominant intestinal microorganisms in 1 month-old full-term babies and weight gain during the first year of life. Gonzalez S, Selma-Royo M, Arboleya S, Martinez-Costa C, Solis G, Suarez M, Fernandez N, de los Reyes-Gavilan C, Diaz-Coto S, Martinez-Camblor P, Collado M, Gueimonde M. Nutrients. 2021 Jul 14;13(7):2412. doi: 10.3390/nu13072412. PMID: 34371922

Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota. Selma-Royo M, García Mantrana I, Calatayud M, Parra-Llorca A, Martinez Costa C, Collado M. European Journal Of Nutrition. 2021 Apr;60(3):1429-1442. doi: 10.1007/s00394-020-02337-7. PMID: 32728880

Maternal Diet Shapes the Breast Milk Microbiota Composition and Diversity: Impact of Mode of Delivery and Antibiotic Exposure. Cortes-Macias E, Selma-Royo M, Garcia-Mantrana I, Calatayud M, Gonzalez S, Martinez-Costa C, Collado M. Journal of Nutrition. 2021 Feb 1;151(2):330-340. doi: 10.1093/jn/nxaa310. PMID: 33188413

Sjogren-Larsson syndrome in Spain: description of three new cases. Villar-Vera C, Cuesta Peredo A, Monfort-Belenguer L, Abellan Sanchez M, Martinez-Costa C. Anales de Pediatria. 2021 Sep;95(3):203-204. doi: 10.1016/j.anpede.2020.07.019. PMID: 34340960

Upper respiratory tract SARS-CoV-2 RNA loads in symptomatic and asymptomatic children and adults. Costa R, Bueno F, Albert E, Torres I, Carbonell-Sahuquillo S, Barres-Fernandez A, Sanchez D, Padron C, Colomina J, Lazaro Carreno M, Breton-Martinez J, Martinez-Costa C, Navarro D. Clinical Microbiology and Infection. 2021 Dec;27(12):1858.e1-1858.e7. doi: 10.1016/j.cmi.2021.08.001. PMID: 34384874

Usefulness of complementary test in the study of patients with chronic abdominal pain. Jimenez Candel MI, Salvador Pinto T, Garcia Peris M, Crehua Gaudiza E, Jovani Casano C, Moreno Ruiz MA, Hernandez Berto T, Largo Blanco E, Martinez Costa C. Anales de Pediatria. 2021 Jul;95(1):26-32. doi: 10.1016/j.anpede.2020.04.021. PMID: 34092539

Vitamin D status in pediatric and young adult cystic fibrosis patients. are the new recommendations effective?. Mangas-Sanchez C, Garriga-Garcia M, Serrano-Nieto MJ, Garcia-Romero R, Alvarez-Beltran M, Crehua-Gaudiza E, Munoz-Codoceo R, Suarez-Cortina L, Vicente-Santamaria S, Martinez-Costa C, Diaz-Martin JJ, Bousono-Garcia C, Gonzalez-Jimenez D. Nutrients. 2021 Dec 9;13(12):4413. doi: 10.3390/nu13124413. PMID: 34959965

Distinct maternal microbiota clusters are associated with diet during pregnancy: impact on neonatal microbiota and infant growth during the first 18 months of life. García Mantrana I, Selma-Royo M, Gonzalez S, Parra-Llorca A, Martinez Costa C, Collado M. Gut Microbes. 2020 Jul 3;11(4):962-978. doi: 10.1080/19490976.2020.1730294. PMID: 32167021

Home and Ambulatory Artificial Nutrition (NADYA) Group Report. Home parenteral nutrition in Spain, 2018. Wanden-Berghe Lozano C, Cuerda Compes C, Maiz Jimenez M, Pereira Cunill J, Ramos Boluda E, Gomez Candela C, Virgili Casas M, Burgos Pelaez R, de Luis Roman D, Penacho Lazaro M, Sanchez Martos E, Martinez Faedo C, Diaz Guardiola P, Alvarez Hernandez J, Zugasti Murillo A, Campos Martin C, Sanz Paris A, Martin Fontalba M, Lobo-Tamer G, Matia Martin M, Carabana Perez F, Martin Folgueras T, Martin Palmero M, Luengo Perez L, Sanchez-Vilar Burdiel O, MARTINEZ COSTA C, Tejera C, Martinez Ramirez M, Garcia Delgado Y, Ponce Gonzalez M, Mauri Roca S, Garcia Zafra M, German Diaz M, Romero V, Molina Baeza B, Gonzalo Marin M, Irles Rocamora J, Sanchez Sanchez R, Apezetxea Celaya A, Joaquin Ortiz C, Suarez Llanos J, Pintor de la Maza B, Leyes Garcia P, Gil Martinez M, Carrera Santaliestra M. Nutricion Hospitalaria. 2020 Apr 16;37(2):403-407. doi: 10.20960/nh.02976. PMID: 32124618

Maternal Microbiota, Cortisol Concentration, and Post-Partum Weight Recovery are Dependent on Mode of Delivery. Selma-Royo M, García Mantrana I, Calatayud M, Parra-Llorca A, Martinez Costa C, Collado M. Nutrients. 2020 Jun 15;12(6):1779. doi: 10.3390/nu12061779. PMID: 32549282

Multicentre longitudinal study of the nutritional status and swallowing difficulties in children with severe neurological diseases. Crehua-Gaudiza E, Garcia-Peris M, Jovani-Casano C, Moreno-Ruiz M, Martinez-Costa C. Revista de Neurologia. 2020 Sep 16;71(6):213-220. doi: 10.33588/rn.7106.2020032. PMID: 32895904

Multicomponent Exercise Training Combined with Nutritional Counselling Improves Physical Function, Biochemical and Anthropometric Profiles in Obese Children: A Pilot Study. Cordellat Marzal A, Padilla Lopez B, Grattarola P, Garcia Lucerga C, Crehuá Gaudiza E, Nuñez Gomez F, Martinez Costa C, Blasco Lafarga M. Nutrients. 2020 Sep 6;12(9):2723. doi: 10.3390/nu12092723. PMID: 32899955

Perinatal environment shapes microbiota colonization and infant growth: impact on host response and intestinal function. Selma-Royo M, Calatayud Arroyo M, Garcia-Mantrana I, Parra-Llorca A, Escuriet R, Martinez-Costa C, Collado M. Microbiome. 2020 Nov 23;8(1):167. doi: 10.1186/s40168-020-00940-8. PMID: 33228771

Proyectos
Referencia: PCIN-2017-117
Título: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Consuelo Borrás Blasco
Duración: 2017 – 2022
Presupuesto: 143.000 €
Referencia: INTIMIC-085
Título: GUTMOM: Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention
Entidad Financiadora: European Commission. JPI HDHL
Investigador principal: Patricia Lozzo
Duración: 2017 – 2020
Presupuesto: 778.240 €
Referencia: MAMI
Título: MAMI – The Power of Maternal Microbes on Infant Health
Entidad Financiadora: European Commission
Investigador principal: María Carmen Collado
Duración: 2015 – 2020
Presupuesto: 1.499.978 €
+ Información
Título: Adaptación transcultural y validación de tres scores para la detección de riesgo de desnutrición pediátrica durante la hospitalización (PNRS, STAMP y STRONGkids). Estimación de la incidencia de desnutrición en nuestro medio
Doctorando: Balaguer López, Evelin
Director: Martínez Costa, Cecilia; Núñez Gómez, Francisco
Fecha: 24/02/2023
Universidad: Universitat de València

Título: Estudio del desarrollo y la función renal, y de aspectos implicados en el síndrome metabólico del adulto, en gemelos con peso dispar al nacimiento. Valoración durante la edad pediátrica
Doctorando: Marín Serra, Juan
Director: Hernández Marco, Roberto; Núñez Gómez, Francisco; Fons Moreno, Jaime
Fecha: 24/10/2022
Universidad: Universitat de València

Título: Anomalías craneofaciales y dentales en una población de escolares nacidos pretérmino
Doctorando: Peiró Guijarro, María Aurora
Director: Martínez Costa, Cecilia; Catalá Picarro, Montserrat; Martínez Rodríguez, Laura
Fecha: 25/03/2022
Universidad: Universitat de València

Título: Efecto de la intervención nutricional en escolares y adolescentes con obesidad con y sin resistencia a la insulina
Doctorando: Grattarola, Ana Paula
Director: Núñez Gómez, Francisco; Martínez Costa, Cecilia
Fecha: 11/01/2021
Universidad: Universitat de València