Grupo de Investigación en Envejecimiento Saludable

Área de Metabolismo y Daño Orgánico


Conocer los mecanismos moleculares implicados en los procesos de envejecimiento y fragilidad para desarrollar posibles métodos de evaluarlos precozmente y desarrollar estrategias de intervención adecuadas.

Determinar un índice de calidad de vida en animales de experimentación.

Desarrollar biomarcadores de imagen en humanos para el diagnóstico de fragilidad

Estudio de dos intervenciones para retrasar el envejecimiento y prevenir la fragilidad:

– Terapia con vesículas extracelulares de pequeño tamaño

– Papel del gen antiapoptótico Bcl-xL

Coordinador
Dra. Consuelo Borrás Blasco
consuelo.borras@uv.es

INVESTIGADORES
R4 Senior
R3 Consolidado

Consuelo Borrás Blasco    
Juan Gambini Buchón

R2 Novel / Emergente

Ana Díaz Cuevas
Mar Dromant Jarque
Marta Inglés de la Torre

R1 Predoctoral

Aurora Román Rodríguez
Jorge Sanz Ros

STAFF
Colaborador/a
Enfermero/a
Técnico/a
Apoyo
Publicaciones
Blood DNA methylation patterns in older adults with evolving dementia. Fernandez Perez R, Alba Linares JJ, Tejedor JR, Fernandez Fernandez A, Calero M, Roman Dominguez A, Borras C, Vina J, Avila J, Medina M, Fernandez Fraga M. The journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Mar 17;glac068. doi: 10.1093/gerona/glac068. PMID: 35299244

Effect of a craniosacral therapy protocol in people with migraine: a randomized controlled trial. Munoz-Gomez E, Ingles M, Aguilar-Rodriguez M, Molla-Casanova S, Sempere-Rubio N, Serra-Ano P, Espi-Lopez G. Journal of Clinical Medicine. 2022 Jan 30;11(3):759. doi: 10.3390/jcm11030759. PMID: 35160211

Effects of foam rolling vs. manual therapy in patients with tension-type headache: a randomized pilot study. Espi-Lopez G, Ingles M, Carrasco-Fernandez J, Serra-Ano P, Copete-Fajardo L, Gonzalez-Gerez J, Saavedra-Hernandez M, Marques-Sule E. Journal of Clinical Medicine. 2022 Mar 23;11(7):1778. doi: 10.3390/jcm11071778. PMID: 35407385

Genistein, a tool for geroscience. Bargues C, Borras C, Vina J. Mechanisms of Ageing and Development. 2022 Mar 17;204:111665. doi: 10.1016/j.mad.2022.111665. PMID: 35307412

Long-lived humans have a unique plasma sphingolipidome. Pradas I, Jove M, Huynh K, Ingles M, Borras C, Mota-Martorell N, Galo-Licona JD, Puig J, Vina J, Meikle PJ, Pamplona R. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Apr 1;77(4):728-735. doi: 10.1093/gerona/glab360. PMID: 34871393

The multimodal action of genistein in Alzheimer’s and other age-related diseases. Mas-Bargues C, Borras C, Vina J. Free Radical Biology & Medicine. 2022 Apr;183:127-137. doi: 10.1016/j.freeradbiomed.2022.03.021. PMID: 35346775

Transcriptomic profile of epileptic children treated with ketogenic therapies. Ruiz-Herrero J, Olaso-Gonzalez G, Serna E, Canedo-Villarroya E, Correas A, Gambini J, Gomez-Cabrera M, Pedron-Giner C, Vina J. Journal of Integrative Neuroscience. 2022 Jan 28;21(1):31. doi: 10.31083/j.jin2101031. PMID: 35164467

A natural xenogeneic endometrial extracellular matrix hydrogel toward improving current human in vitro models and future in vivo applications. Lopez-Martinez S, Campo H, de Miguel-Gomez L, Faus A, Navarro A, Diaz A, Pellicer A, Ferrero H, Cervello I. Frontiers in Bioengineering and Biotechnology. 2021 Mar 5;9:639688. doi: 10.3389/fbioe.2021.639688. PMID: 33748086

Anti-inflammatory properties of diet: role in healthy aging.Stromsnes K, Correas A, Lehmann J, Gambini J, Olaso-Gonzalez G. Biomedicines. 2021 Jul 30;9(8):922. doi: 10.3390/biomedicines9080922. PMID: 34440125

Attitudes towards learning professional ethics in undergraduate physiotherapy students: A STROBE compliant cross-sectional study. Marques-Sule E, Arnal-Gomez A, Cortes-Amador S, de la Torre M, Hernandez D, Aguilar-Rodriguez M. Nurse Education Today. 2021 Mar;98:104771. doi: 10.1016/j.nedt.2021.104771. PMID: 33529858

Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395

Bioengineered endometrial hydrogels with growth factors promote tissue regeneration and restore fertility in murine models. Lopez-Martinez S, Rodriguez-Eguren A, de Miguel-Gomez L, Frances-Herrero E, Faus A, Diaz A, Pellicer A, Ferrero H, Cervello I. Acta Biomaterialia. 2021 Nov;135:113-125. doi: 10.1016/j.actbio.2021.08.025. PMID: 34428563

Biomechanical and viscoelastic properties of the ankle muscles in men with previous history of ankle sprain. Serra-Ano P, Ingles M, Espi-Lopez G, Sempere-Rubio N, Aguilar-Rodriguez M. Journal of Biomechanics. 2021 Jan 22;115:110191. doi: 10.1016/j.jbiomech.2020.110191. PMID: 33385869

Decellularized tracheal prelamination implant: A proposed bilateral double organ technique. Martinez-Hernandez N, Diaz-Cuevas A, Milian-Medina L, Sancho-Tello M, Rosello-Ferrando J, Morcillo-Aixela A, Campo-Canaveral J, Roig-Bataller A, Mata-Roig M. Artificial Organs. 2021 Dec;45(12):1491-1500. doi: 10.1111/aor.14043. PMID: 34310703

Diagnostic performance of muscle echo intensity and fractal dimension for the detection of frailty phenotype. Miron Mombiela R, Vucetic J, Monllor P, Cardenas-Herran JS, Taltavull de la Paz P, Borras C. Ultrasonic Imaging. 2021 Nov;43(6):337-352. doi: 10.1177/01617346211029656. PMID: 34238072

Domestic pig prioritized in one health action against fascioliasis in human endemic areas: Experimental assessment of transmission capacity and epidemiological evaluation of reservoir role. Mas-Coma S, Funatsu IR, Angles R, Buchon P, Mas Bargues C, Artigas P, Valero MA, Bargues MD. One Health. 2021 Apr 16;13:100249. doi: 10.1016/j.onehlt.2021.100249. PMID: 33997234

Effectiveness of a manual therapy protocol based on articulatory techniques in migraine patients. A randomized controlled trial. Munoz-Gomez E, Ingles M, Serra-Ano P, Espi-Lopez GV. Musculoskeletal Science & Practice. 2021 Apr 30;54:102386. doi: 10.1016/j.msksp.2021.102386. PMID: 33989990

Effectiveness of high-frequency transcranial magnetic stimulation and physical exercise in women with fibromyalgia: a randomized controlled trial. Izquierdo-Alventosa R, Ingles M, Cortes-Amador S, Gimeno-Mallench L, Sempere-Rubio N, Serra-Ano P. Physical Therapy & Rehabilitation Journal. 2021 Oct 1;101(10):pzab159. doi: 10.1093/ptj/pzab159. PMID: 34216139

Effects of balance training on functionality, ankle instability, and dynamic balance outcomes in people with chronic ankle instability: Systematic review and meta-analysis. Molla-Casanova S, Ingles M, Serra-Ano P. Clinical Rehabilitation. 2021 Dec;35(12):1694-1709. doi: 10.1177/02692155211022009. PMID: 34058832

Efficacy of a proprioceptive exercise program in patients with nonspecific neck pain. A randomized controlled trial. Espí López G, Aguilar Rodríguez M, Zarzoso Muñoz M, Serra Año M, Martinez De La Fuente J, Inglés De La Torre M, Marques-Sule E. European Journal of Physical and Rehabilitation Medicine. 2021 Jun;57(3):397-405. doi: 10.23736/S1973-9087.20.06302-9. PMID: 33047944

Estrogen replacement therapy induces antioxidant and longevity-related genes in women after medically induced menopause. Borras C, Ferrando M, Ingles M, Gambini J, Lopez-Grueso R, Edo R, Mas-Bargues C, Pellicer A, Vina J. Oxidative Medicine and Cellular Longevity. 2021 Sep 9;2021:8101615. doi: 10.1155/2021/8101615. PMID: 34539974

Exploring new kingdoms: the role of extracellular vesicles in oxi-inflamm-aging related to cardiorenal syndrome. Mas-Bargues C, Alique M, Barrus-Ortiz M, Borras C, Rodrigues-Diez R. Antioxidants. 2021 Dec 29;11(1):78. doi: 10.3390/antiox11010078. PMID: 35052582

Importance of stem cell culture conditions for their derived extracellular vesicles therapeutic effect. Mas-Bargues C, Borras C. Free Radical Biology & Medicine. 2021 May 20;168:16-24. doi: 10.1016/j.freeradbiomed.2021.03.028. PMID: 33781893

Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Borras C, Abdelaziz KM, Diaz A, Gambini J, Jove M, Lopez-Grueso R, Mas-Bargues C, Monleon D, Pamplona R, Vina J. Mechanisms of Ageing and Development. 2021 Dec;200:111596. doi: 10.1016/j.mad.2021.111596. PMID: 34774606

Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Mas-Bargues C, Escrivá C, Dromant M, Borrás C, Viña J. Archives of Biochemistry and Biophysics. 2021 Sep 30;709:108941. doi: 10.1016/j.abb.2021.108941. PMID: 34097903

Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Gambini J, Gimeno-Mallench L, Olaso-Gonzalez G, Mastaloudis A, Traber M, Monleon D, Borras C, Vina J. Antioxidants. 2021 Feb 16;10(2):301. doi: 10.3390/antiox10020301. PMID: 33669360

Pharmacological properties of polyphenols: bioavailability, mechanisms of action, and biological effects in in vitro studies, animal models, and humans. Stromsnes K, Lagzdina R, Olaso-Gonzalez G, Gimeno-Mallench L, Gambini J. Biomedicines. 2021 Aug 23;9(8):1074. doi: 10.3390/biomedicines9081074. PMID: 34440278

Role of antiangiogenic VEGF-A165b in angiogenesis and systolic function after reperfused myocardial infarction. Rios Navarro C, Hueso Soler L, Diaz Cuevas A, Marcos Garcés V, Bonanad Lozano C, Ruiz Sauri A, Vila Salinas J, Sanz Ferrando M, Chorro Gascó F, Piqueras Ruiz L, Bodí Peris V. Revista espanola de Cardiologia (English ed.). 2021 Feb;74(2):131-139. doi: 10.1016/j.rec.2020.03.013. PMID: 32474003

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates. Duro-Castano A, Borras C, Herranz-Perez V, Blanco-Gandia M, Conejos-Sanchez I, Arminan A, Mas-Bargues C, Ingles M, Minarro J, Rodriguez-Arias M, Garcia-Verdugo J, Vina J, Vicent M. Science Advances. 2021 Mar 26;7(13):eabf9180. doi: 10.1126/sciadv.abf9180. PMID: 33771874

Thermal imaging ruled out as a supplementary assessment in patients with fibromyalgia: a cross-sectional study. Sempere-Rubio N, Aguilar-Rodriguez M, Ingles M, Izquierdo-Alventosa R, Serra-Ano P. PLoS One. 2021 Jun 16;16(6):e0253281. doi: 10.1371/journal.pone.0253281. PMID: 34133467

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. NCD Risk Factor Collaboration. Lancet. 2021 Sep 11;398(10304):957-980. doi: 10.1016/S0140-6736(21)01330-1. PMID: 34450083

Assessment of Functional Activities in Individuals with Parkinson’s Disease Using a Simple and Reliable Smartphone-Based Procedure. Serra Año M, Pedrero-Sanchez J, Inglés De La Torre M, Aguilar-Rodriguez M, Vargas-Villanueva I, Lopez-Pascual J. International Journal of Environmental Research and Public Health. 2020 Jun 9;17(11):4123. doi: 10.3390/ijerph17114123. PMID: 32527031

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. Borras Blasco C, Mas Bargues C, Roman-Dominguez A, Sanz Ros J, Gimeno Mallench L, Inglés De La Torre M, Gambini Buchon J, Viña Ribes J. International Journal of Molecular Sciences. 2020 Jan 9;21(2):418. doi: 10.3390/ijms21020418. PMID: 31936510

Centenarians: An excellent example of resilience for successful ageing. Borras Blasco C, Inglés De La Torre M, Mas Bargues C, Dromant M, Sanz Ros J, Roman-Dominguez A, Gimeno Mallench L, Gambini Buchon J, Viña Ribes J. Mechanisms of Ageing and Development. 2020 Mar;186:111199. doi: 10.1016/j.mad.2019.111199. PMID: 31899226

Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial. Izquierdo-Alventosa R, Inglés De La Torre M, Cortes-Amador S, Gimeno Mallench L, Sempere Rubio N, Chirivella J, Serra Año M. Therapeutic advances in musculoskeletal disease. 2020 Jun 24;12:1759720X20930493. doi: 10.1177/1759720X20930493. PMID: 32636943

Development and Long-Term Follow-Up of an Experimental Model of Myocardial Infarction in Rabbits. Genovés Martínez P, Arias Mutis Ó, Parra Giraldo G, Such Miquel L, Zarzoso Muñoz M, Del Canto Serrano I, Soler Lopez C, Diaz Cuevas A, Blanch Torres E, Alberola Aguilar A, Such Belenguer L, Chorro Gascó F. Animals. 2020 Sep 4;10(9):1576. doi: 10.3390/ani10091576. PMID: 32899601

Donkey fascioliasis within a one health control action: transmission capacity, field epidemiology, and reservoir role in a human hyperendemic área. Mas-Coma S, Buchon P, Funatsu I, Angles R, Mas Bargues C, Artigas P, Valero M, Bargues M. Frontiers in Veterinary Science. 2020 Nov 5;7:591384. doi: 10.3389/fvets.2020.591384. PMID: 33251272

Effect of manual therapy and splint therapy in people with temporomandibular disorders: a preliminary study. Espí López G, Arnal-Gomez A, Cuerda Del Pino A, Benavent-Corai J, Serra Año M, Inglés De La Torre M. Journal of Clinical Medicine. 2020 Jul 28;9(8):2411. doi: 10.3390/jcm9082411. PMID: 32731453

Extracellular vesicles and redox modulation in aging. Borras Blasco C, Mas Bargues C, Sanz Ros J, Román Domínguez M, Gimeno Mallench L, Inglés De La Torre M, Gambini Buchon J, Viña Ribes J. Free Radical Biology and Medicine. 2020 Mar;149:44-50. doi: 10.1016/j.freeradbiomed.2019.11.032. PMID: 31783096

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1alpha Activation. Mas Bargues C, Sanz Ros J, Román Domínguez M, Gimeno Mallench L, Inglés De La Torre M, Viña Ribes J, Borras Blasco C. Biomolecules. 2020 Jun 25;10(6):957. doi: 10.3390/biom10060957. PMID: 32630449

Garcinoic acid prevents beta-amyloid (Abeta) deposition in the mouse brain. Marinelli R, Torquato P, Bartolini D, Mas Bargues C, Bellezza G, Gioiello A, Borras Blasco C, De Luca A, Fallarino F, Sebastiani B, Mani S, Sidoni A, Viña Ribes J, Leri M, Bucciantini M, Nardiello P, Casamenti F, Galli F. Journal of biological chemistry. 2020 Aug 14;295(33):11866-11876. doi: 10.1074/jbc.RA120.013303. PMID: 32616652

Low-Intensity Physical Exercise Improves Pain Catastrophizing and Other Psychological and Physical Aspects in Women with Fibromyalgia: A Randomized Controlled Trial. Izquierdo-Alventosa R, Inglés De La Torre M, Cortes-Amador S, Gimeno Mallench L, Chirivella-Garrido J, Kropotov J, Serra Año M. International Journal of Environmental Research and Public Health. 2020 May 21;17(10):3634. doi: 10.3390/ijerph17103634. PMID: 32455853

Methionine transsulfuration pathway is upregulated in long-lived humans. Mota-Martorell N, Mariona J, Consuelo B, Rebeca B, Elia O, Joaquim S, Rosanna C, Irene P, Galo-Licona J, Josep P, Jose V, Reinald P. Free Radical Biology & Medicine. 2020 Nov 30;162:38-52. doi: 10.1016/j.freeradbiomed.2020.11.026. PMID: 33271279

Numerous Fasciola plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis (vol 146, pg 284, 2019). Gonzalez-Miguel J, Valero M, Reguera-Gomez M, Mas Bargues C, Bargues M, Simon-Martin F, Mas-Coma S. Parasitology. 2020 May;147(6):729. doi: 10.1017/S0031182020000268. PMID: 32052717

Oxidative stress and exceptional human longevity: Systematic review. Belenguer-Varea A, Tarazona-Santabalbina F, Avellana-Zaragoza J, Martinez-Reig M, Mas Bargues C, Inglés De La Torre M. Free Radical Biology and Medicine. 2020 Mar;149:51-63. doi: 10.1016/j.freeradbiomed.2019.09.019. PMID: 31550529

Paths of the cervical instantaneous axis of rotation during active movements-patterns and reliability.Venegas W, Inglés De La Torre M, Page A, Serra-Ano P. Medical & Biological Engineering & Computing. 2020 May;58(5):1147-1157. doi: 10.1007/s11517-020-02153-5. PMID: 32193862

Protective Effects of Polyphenols Present in Mediterranean Diet on Endothelial Dysfunction. Stromsnes K, Mas-Bargues C, Gambini J, Gimeno-Mallench L. Oxidative medicine and cellular longevity. 2020 Aug 6;2020:2097096. doi: 10.1155/2020/2097096. PMID: 32831990

Relationship between Diet, Microbiota, and Healthy Aging. Sanchez-Morate E, Gimeno Mallench L, Stromsnes K, Sanz Ros J, Roman-Dominguez A, Parejo-Pedrajas S, Inglés De La Torre M, Olaso González G, Gambini Buchon J, Mas Bargues C. Biomedicines. 2020 Aug 14;8(8):287. doi: 10.3390/biomedicines8080287. PMID: 32823858

Special issue: Redox Signalling in Health and Disease. Borras Blasco C, Viña Ribes J. Free Radical Biology And Medicine. 2020 Mar;149:1. doi: 10.1016/j.freeradbiomed.2020.02.009. PMID: 32061736

The Relationship between Diet and Frailty in Aging. Gimeno Mallench L, Sanchez-Morate E, Parejo-Pedrajas S, Mas Bargues C, Inglés De La Torre M, Sanz Ros J, Roman-Dominguez A, Olaso González G, Stromsnes K, Gambini Buchon J. Endocrine, Metabolic & Immune Disorders Drug Targets. 2020;20(9):1373-1382. doi: 10.2174/1871530320666200513083212. PMID: 32400339

Proyectos
Referencia: AC20/00026
Título: Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK of protein energy malnutrition in pre-dementia AGEd people. ERA-HDHL Call for Joint Transnational Research Proposals on Development of targeted nutrition for prevention of undernutrition for older adults (PREVNUT)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: José Viña Ribes
Duración: 2021 – 2023
Presupuesto: 169.098 €

Referencia: PID2020-113839RB-I00
Título: Efecto del tratamiento con vesículas extracelulares de células madre de grasa de ratones jóvenes sobre parámetros de envejecimiento y fragilidad en ratones de edad avanzada
Entidad Financiadora: Ministerio de Ciencia e Innovación
Investigador principal: Consuelo Borrás Blasco
Duración: 2021 – 2024
Presupuesto: 181.500 €

Referencia: GV/2018/067
Título: Estudio de posibles huellas genéticas de envejecimiento saludable en descendientes de centenarios
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Marta Inglés de la Torre
Duración: 2018 – 2019
Presupuesto: 12.040 €

Referencia: PCIN-2017-117
Título: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Consuelo Borrás Blasco
Duración: 2017 – 2022
Presupuesto: 143.000 €

+ Información
Título: Transcriptómica en centenarios: un ejemplo de envejecimiento satisfactorio
Doctorando: Dromant Jarque, Mar
Director: Inglés De La Torre, Marta; Borrás Blasco, Consuelo; Viña Ribes, José
Fecha: 21/12/2021
Universidad: Universitat de València

Título: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctorando: Mirón Mombiela, Rebeca
Director: Borrás Blasco, Consuelo; Forner Giner, Juana
Fecha: 28/01/2019
Universidad: Universitat de València

Título: Eficacia de la terapia manual en pacientes con migraña
Doctorando: Muñoz Gómez, Elena
Director: Inglés De La Torre, Marta; Espí López, Gemma Victoria
Fecha: 23/04/2021
Universidad: Universitat de València

Título: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctorando: Muñoz Cebriá, José Enrique
Director: Viña, José; Borrás, Consuelo; Gambini, Juan
Fecha: 01/07/2020
Universidad: Universitat de València