Grupo de Investigación en Envejecimiento Saludable

Área de Metabolismo y Daño Orgánico

Conocer los mecanismos moleculares implicados en los procesos de envejecimiento y fragilidad para desarrollar posibles métodos de evaluarlos precozmente y desarrollar estrategias de intervención adecuadas

Determinar un índice de calidad de vida en animales de experimentación

Desarrollar biomarcadores de imagen en humanos para el diagnóstico de fragilidad

Estudio de dos intervenciones para retrasar el envejecimiento y prevenir la fragilidad:

– Terapia con vesículas extracelulares de pequeño tamaño

– Papel del gen antiapoptótico Bcl-xL

Coordinador
Dra. Consuelo Borrás Blasco
consuelo.borras@uv.es

INVESTIGADORES
R4 Senior
R3 Consolidado

Consuelo Borrás Blasco    

R2 Novel / Emergente

Ana Díaz Cuevas
Cristina Mas Bargues
Marta Inglés de la Torre
Juan Gambini Buchón    

R1 Predoctoral

Aurora Román Rodríguez
Jorge Sanz Ros
Mar Dromant Jarque

STAFF
Colaborador/a
Enfermero/a
Técnico/a
Apoyo
Publicaciones
Anti-inflammatory properties of diet: role in healthy aging.Stromsnes K, Correas A, Lehmann J, Gambini J, Olaso-Gonzalez G. Biomedicines. 2021 Jul 30;9(8):922. doi: 10.3390/biomedicines9080922. PMID: 34440125

Attitudes towards learning professional ethics in undergraduate physiotherapy students: A STROBE compliant cross-sectional study. Marques-Sule E, Arnal-Gomez A, Cortes-Amador S, de la Torre M, Hernandez D, Aguilar-Rodriguez M. Nurse Education Today. 2021 Mar;98:104771. doi: 10.1016/j.nedt.2021.104771. PMID: 33529858

Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395

Decellularized tracheal prelamination implant: A proposed bilateral double organ technique. Martinez-Hernandez N, Diaz-Cuevas A, Milian-Medina L, Sancho-Tello M, Rosello-Ferrando J, Morcillo-Aixela A, Campo-Canaveral J, Roig-Bataller A, Mata-Roig M. Artificial Organs. 2021 Jul 26. doi: 10.1111/aor.14043. PMID: 34310703

Diagnostic performance of muscle echo intensity and fractal dimension for the detection of frailty phenotype. Miron Mombiela R, Vucetic J, Monllor P, Cardenas-Herran JS, Taltavull de la Paz P, Borras C. Ultrasonic Imaging. 2021 Jul 8;1617346211029656. doi: 10.1177/01617346211029656. PMID: 34238072

Domestic pig prioritized in one health action against fascioliasis in human endemic areas: Experimental assessment of transmission capacity and epidemiological evaluation of reservoir role. Mas-Coma S, Funatsu IR, Angles R, Buchon P, Mas Bargues C, Artigas P, Valero MA, Bargues MD. One Health. 2021 Apr 16;13:100249. doi: 10.1016/j.onehlt.2021.100249. PMID: 33997234

Effectiveness of a manual therapy protocol based on articulatory techniques in migraine patients. A randomized controlled trial. Munoz-Gomez E, Ingles M, Serra-Ano P, Espi-Lopez GV. Musculoskeletal Science & Practice. 2021 Apr 30;54:102386. doi: 10.1016/j.msksp.2021.102386. PMID: 33989990

Efficacy of a proprioceptive exercise program in patients with nonspecific neck pain. A randomized controlled trial. Espí López G, Aguilar Rodríguez M, Zarzoso Muñoz M, Serra Año M, Martinez De La Fuente J, Inglés De La Torre M, Marques-Sule E. European Journal of Physical and Rehabilitation Medicine. 2021 Jun;57(3):397-405. doi: 10.23736/S1973-9087.20.06302-9. PMID: 33047944

Importance of stem cell culture conditions for their derived extracellular vesicles therapeutic effect. Mas-Bargues C, Borras C. Free Radical Biology & Medicine. 2021 May 20;168:16-24. doi: 10.1016/j.freeradbiomed.2021.03.028. PMID: 33781893

Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease.

Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Gambini J, Gimeno-Mallench L, Olaso-Gonzalez G, Mastaloudis A, Traber M, Monleon D, Borras C, Vina J. Antioxidants. 2021 Feb 16;10(2):301. doi: 10.3390/antiox10020301. PMID: 33669360

Pharmacological properties of polyphenols: bioavailability, mechanisms of action, and biological effects in in vitro studies, animal models, and humans. Stromsnes K, Lagzdina R, Olaso-Gonzalez G, Gimeno-Mallench L, Gambini J. Biomedicines. 2021 Aug 23;9(8):1074. doi: 10.3390/biomedicines9081074. PMID: 34440278

Role of antiangiogenic VEGF-A165b in angiogenesis and systolic function after reperfused myocardial infarction. Rios Navarro C, Hueso Soler L, Diaz Cuevas A, Marcos Garcés V, Bonanad Lozano C, Ruiz Sauri A, Vila Salinas J, Sanz Ferrando M, Chorro Gascó F, Piqueras Ruiz L, Bodí Peris V. Revista espanola de Cardiologia (English ed.). 2021 Feb;74(2):131-139. doi: 10.1016/j.rec.2020.03.013. PMID: 32474003

Assessment of Functional Activities in Individuals with Parkinson’s Disease Using a Simple and Reliable Smartphone-Based Procedure. Serra Año M, Pedrero-Sanchez J, Inglés De La Torre M, Aguilar-Rodriguez M, Vargas-Villanueva I, Lopez-Pascual J. International Journal of Environmental Research and Public Health. 2020 Jun 9;17(11):4123. doi: 10.3390/ijerph17114123. PMID: 32527031

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. Borras Blasco C, Mas Bargues C, Roman-Dominguez A, Sanz Ros J, Gimeno Mallench L, Inglés De La Torre M, Gambini Buchon J, Viña Ribes J. International Journal of Molecular Sciences. 2020 Jan 9;21(2):418. doi: 10.3390/ijms21020418. PMID: 31936510

Biomechanical and viscoelastic properties of the ankle muscles in men with previous history of ankle sprain. Serra-Ano P, Ingles M, Espi-Lopez G, Sempere-Rubio N, Aguilar-Rodriguez M. Journal of Biomechanics. 2020 Dec 29;115:110191. doi: 10.1016/j.jbiomech.2020.110191. PMID: 33385869

Centenarians: An excellent example of resilience for successful ageing. Borras Blasco C, Inglés De La Torre M, Mas Bargues C, Dromant M, Sanz Ros J, Roman-Dominguez A, Gimeno Mallench L, Gambini Buchon J, Viña Ribes J. Mechanisms of Ageing and Development. 2020 Mar;186:111199. doi: 10.1016/j.mad.2019.111199. PMID: 31899226

Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial. Izquierdo-Alventosa R, Inglés De La Torre M, Cortes-Amador S, Gimeno Mallench L, Sempere Rubio N, Chirivella J, Serra Año M. Therapeutic advances in musculoskeletal disease. 2020 Jun 24;12:1759720X20930493. doi: 10.1177/1759720X20930493. PMID: 32636943

Development and Long-Term Follow-Up of an Experimental Model of Myocardial Infarction in Rabbits. Genovés Martínez P, Arias Mutis Ó, Parra Giraldo G, Such Miquel L, Zarzoso Muñoz M, Del Canto Serrano I, Soler Lopez C, Diaz Cuevas A, Blanch Torres E, Alberola Aguilar A, Such Belenguer L, Chorro Gascó F. Animals. 2020 Sep 4;10(9):1576. doi: 10.3390/ani10091576. PMID: 32899601

Donkey fascioliasis within a one health control action: transmission capacity, field epidemiology, and reservoir role in a human hyperendemic área. Mas-Coma S, Buchon P, Funatsu I, Angles R, Mas Bargues C, Artigas P, Valero M, Bargues M. Frontiers in Veterinary Science. 2020 Nov 5;7:591384. doi: 10.3389/fvets.2020.591384. PMID: 33251272

Effect of manual therapy and splint therapy in people with temporomandibular disorders: a preliminary study. Espí López G, Arnal-Gomez A, Cuerda Del Pino A, Benavent-Corai J, Serra Año M, Inglés De La Torre M. Journal of Clinical Medicine. 2020 Jul 28;9(8):2411. doi: 10.3390/jcm9082411. PMID: 32731453

Extracellular vesicles and redox modulation in aging. Borras Blasco C, Mas Bargues C, Sanz Ros J, Román Domínguez M, Gimeno Mallench L, Inglés De La Torre M, Gambini Buchon J, Viña Ribes J. Free Radical Biology and Medicine. 2020 Mar;149:44-50. doi: 10.1016/j.freeradbiomed.2019.11.032. PMID: 31783096

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1alpha Activation. Mas Bargues C, Sanz Ros J, Román Domínguez M, Gimeno Mallench L, Inglés De La Torre M, Viña Ribes J, Borras Blasco C. Biomolecules. 2020 Jun 25;10(6):957. doi: 10.3390/biom10060957. PMID: 32630449

Garcinoic acid prevents beta-amyloid (Abeta) deposition in the mouse brain. Marinelli R, Torquato P, Bartolini D, Mas Bargues C, Bellezza G, Gioiello A, Borras Blasco C, De Luca A, Fallarino F, Sebastiani B, Mani S, Sidoni A, Viña Ribes J, Leri M, Bucciantini M, Nardiello P, Casamenti F, Galli F. Journal of biological chemistry. 2020 Aug 14;295(33):11866-11876. doi: 10.1074/jbc.RA120.013303. PMID: 32616652

Low-Intensity Physical Exercise Improves Pain Catastrophizing and Other Psychological and Physical Aspects in Women with Fibromyalgia: A Randomized Controlled Trial. Izquierdo-Alventosa R, Inglés De La Torre M, Cortes-Amador S, Gimeno Mallench L, Chirivella-Garrido J, Kropotov J, Serra Año M. International Journal of Environmental Research and Public Health. 2020 May 21;17(10):3634. doi: 10.3390/ijerph17103634. PMID: 32455853

Methionine transsulfuration pathway is upregulated in long-lived humans. Mota-Martorell N, Mariona J, Consuelo B, Rebeca B, Elia O, Joaquim S, Rosanna C, Irene P, Galo-Licona J, Josep P, Jose V, Reinald P. Free Radical Biology & Medicine. 2020 Nov 30;162:38-52. doi: 10.1016/j.freeradbiomed.2020.11.026. PMID: 33271279

Numerous Fasciola plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis (vol 146, pg 284, 2019). Gonzalez-Miguel J, Valero M, Reguera-Gomez M, Mas Bargues C, Bargues M, Simon-Martin F, Mas-Coma S. Parasitology. 2020 May;147(6):729. doi: 10.1017/S0031182020000268. PMID: 32052717

Oxidative stress and exceptional human longevity: Systematic review. Belenguer-Varea A, Tarazona-Santabalbina F, Avellana-Zaragoza J, Martinez-Reig M, Mas Bargues C, Inglés De La Torre M. Free Radical Biology and Medicine. 2020 Mar;149:51-63. doi: 10.1016/j.freeradbiomed.2019.09.019. PMID: 31550529

Paths of the cervical instantaneous axis of rotation during active movements-patterns and reliability.Venegas W, Inglés De La Torre M, Page A, Serra-Ano P. Medical & Biological Engineering & Computing. 2020 May;58(5):1147-1157. doi: 10.1007/s11517-020-02153-5. PMID: 32193862

Protective Effects of Polyphenols Present in Mediterranean Diet on Endothelial Dysfunction. Stromsnes K, Mas-Bargues C, Gambini J, Gimeno-Mallench L. Oxidative medicine and cellular longevity. 2020 Aug 6;2020:2097096. doi: 10.1155/2020/2097096. PMID: 32831990

Relationship between Diet, Microbiota, and Healthy Aging. Sanchez-Morate E, Gimeno Mallench L, Stromsnes K, Sanz Ros J, Roman-Dominguez A, Parejo-Pedrajas S, Inglés De La Torre M, Olaso González G, Gambini Buchon J, Mas Bargues C. Biomedicines. 2020 Aug 14;8(8):287. doi: 10.3390/biomedicines8080287. PMID: 32823858

Special issue: Redox Signalling in Health and Disease. Borras Blasco C, Viña Ribes J. Free Radical Biology And Medicine. 2020 Mar;149:1. doi: 10.1016/j.freeradbiomed.2020.02.009. PMID: 32061736

The Relationship between Diet and Frailty in Aging. Gimeno Mallench L, Sanchez-Morate E, Parejo-Pedrajas S, Mas Bargues C, Inglés De La Torre M, Sanz Ros J, Roman-Dominguez A, Olaso González G, Stromsnes K, Gambini Buchon J. Endocrine, Metabolic & Immune Disorders Drug Targets. 2020;20(9):1373-1382. doi: 10.2174/1871530320666200513083212. PMID: 32400339

Centenarians overexpress pluripotency-related genes. Inglés M, Mas-Bargues C, Berna-Erro A, Matheu A, Sanchís P, Avellana JA, Borrás C, Viña J. Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 2019 Aug 16;74(9):1391-1395. doi: 10.1093/gerona/gly168. PMID: 30052797

Effect of Kinesio taping on clinical symptoms in people with fibromyalgia: A randomized clinical trial. Espí-López GV, Inglés M, Ferrando AC, Serra-Añó P. Journal of Back And Musculoskeletal Rehabilitation. 2019;32(4):561-567. doi: 10.3233/BMR-171100. PMID: 30530959

Effectiveness of myofascial release after breast cancer surgery in women undergoing conservative surgery and radiotherapy: a randomized controlled trial. Serra-Añó P, Inglés M, Bou-Catalá C, Iraola-Lliso A, Espí-López GV. Supportive Care in Cancer. 2019 Jul;27(7):2633-2641. doi: 10.1007/s00520-018-4544-z. PMID: 30470892

Effects of Taping and Balance Exercises on Knee and Lower Extremity Function in Amateur Soccer Players: A Randomized Controlled Trial. Espí-López GV, Serra-Añó P, Cobo-Pascual D, Zarzoso M, Suso-Martí L, Cuenca-Martínez F, Inglés M. Journal of Sport Rehabilitation. 2019 May 16:1-25. doi: 10.1123/jsr.2018-0452. PMID: 31094640

Exceptional human longevity is associated with a specific plasma phenotype of ether lipids. Pradas I, Jové M, Huynh K, Puig J, Ingles M, Borras C, Viña J, Meikle PJ, Pamplona R. Redox Biology. 2019 Feb;21:101127. doi: 10.1016/j.redox.2019.101127. PMID: 30711699

Mobility assessment in people with Alzheimer disease using smartphone sensors. Serra-Añó P, Pedrero-Sánchez JF, Hurtado-Abellán J, Inglés M, Espí-López GV, López-Pascual J. Journal of NeuroEngineering and Rehabilitation. 2019 Aug 14;16(1):103. doi: 10.1186/s12984-019-0576-y. PMID: 31412893

Numerous Fasciola plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis. González-Miguel J, Valero MA, Reguera-Gomez M, Mas-Bargues C, Bargues MD, Simón F, Mas-Coma S. Parasitology. 2019 Mar;146(3):284-298. doi: 10.1017/S0031182018001464. PMID: 30246668

Redox lipidomics to better understand brain aging and function. Pamplona R, Borras C, Jové M, Pradas I, Ferrer I, Viña J. Free radical biology & medicine. 2019 Nov 20;144:310-321. doi: 10.1016/j.freeradbiomed.2019.03.016. PMID: 30898667

Relation Between Genetic Factors and Frailty in Older Adults. Inglés M, Mas-Bargues C, Gimeno-Mallench L, Cruz-Guerrero R, García-García FJ, Gambini J, Borrás C, Rodríguez-Mañas L, Viña J. Journal of the American Medical Directors Association. 2019 Nov;20(11):1451-1457. doi: 10.1016/j.jamda.2019.03.011. PMID: 31078485

Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine. Mas-Bargues C, Sanz-Ros J, Román-Domínguez A, Inglés M, Gimeno-Mallench L, El Alami M, Viña-Almunia J, Gambini J, Viña J, Borrás C. International Journal of Molecular Sciences. 2019 Mar 8;20(5):1195. doi: 10.3390/ijms20051195. PMID: 30857245

Resveratrol shifts energy metabolism to increase lipid oxidation in healthy old mice. Gimeno-Mallench L, Mas-Bargues C, Inglés M, Olaso G, Borras C, Gambini J, Vina J. Biomedicine & Pharmacotherapy. 2019 Oct;118:109130. doi: 10.1016/j.biopha.2019.109130. PMID: 31306969

Sex Differences in Age-Associated Type 2 Diabetes in Rats-Role of Estrogens and Oxidative Stress. Díaz A, López-Grueso R, Gambini J, Monleón D, Mas-Bargues C, Abdelaziz KM, Viña J, Borrás C. Oxidative Medicine and Cellular Longevity. 2019 Apr 7;2019:6734836. doi: 10.1155/2019/6734836. PMID: 31089412

SOX2 expression diminishes with ageing in several tissues in mice and humans. Carrasco-Garcia E, Moreno-Cugnon L, Garcia I, Borras C, Revuelta M, Izeta A, Lopez-Lluch G, de Pancorbo MM, Vergara I, Vina J, Matheu A. Mechanisms of Ageing and Development. 2019 Jan;177:30-36. doi: 10.1016/j.mad.2018.03.008. PMID: 29574045

Proyectos
Referencia: GV/2018/067
Título: Estudio de posibles huellas genéticas de envejecimiento saludable en descendientes de centenarios
Entidad Financiadora: Conselleria de Educación Cultura y Deporte
Investigador principal: Marta Inglés de la Torre
Duración: 2018 – 2019
Presupuesto: 12.040 €

Referencia: PCIN-2017-117
Título: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: Consuelo Borrás Blasco
Duración: 2017 – 2020
Presupuesto: 143.000 €

+ Información
Título: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctorando: Mirón Mombiela, Rebeca
Director: Borrás Blasco, Consuelo; Forner Giner, Juana
Fecha: 28/01/2019
Universidad: Universitat de València

Título: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctorando: Muñoz Cebriá, José Enrique
Director: Viña, José; Borrás, Consuelo; Gambini, Juan
Fecha: 01/07/2020
Universidad: Universitat de València

Título: Eficacia de la terapia manual en pacientes con migraña
Doctorando: Muñoz Gómez, Elena
Director: Inglés De La Torre, Marta; Espí López, Gemma Victoria
Fecha: 23/04/2021
Universidad: Universitat de València