Área Oncología

Skin Cancer research group

José Carlos Monteagudo Castro

Dr. Monteagudo Graduated in Medicine and Surgery from the University of Valencia in 1982, completing his training as a medical doctor specializing in Anatomy and Pathology at the Hospital Clínico Universitario in Valencia (Resident Intern Physician: 1984-1988).

He obtained a Fogarty grant from the National Institutes of Health (NIH) in the USA for biomedical, immunochemistry, and molecular biology research at the pathology laboratory at the National Cancer Institute (NCI), Bethesda, Maryland (1988-1990). Subsequently, he obtained his doctorate with cum laude honors in 1990 from the University of Valencia.

He is now a permanent Senior Professor of Pathological Anatomy at the University of Valencia and is the head of the Pathological Anatomy Section at the Hospital Clínico Universitario in Valencia. He is also a member of the Valencian Autonomous Community’s Royal Academy of Medicine and Science (Reial Acadèmia de Medicina i Ciències de la Comunitat Valenciana). 

He has focused on two different lines of research over the last 25 years: one referring to pathogenic mechanisms and diagnostic and prognostic indicators of skin neoplasms, with a greater emphasis on melanoma over the past decade. He is the Principal Investigator on 7 autonomous and nationally-funded projects related to this line of research. The second line looks at molecular mechanisms of the dissemination and virulence of Candida albicans in experimental systemic candidiasis models; he is a collaborating researcher at the University of Texas Health Science Center and the Biology Department of the University of Texas in San Antonio, TX, USA on this project. He has also been a consultant medical doctor at the San Antonio Center for Medical Mycology (SACMM). The result of all of this work combined is more than 200 scientific publications. He is a member of the Editorial Board of the Spanish Pathology journal and is also an in-house reviewer for several international journals, mainly on the topics of dermatology, dermatopathology, and infectious pathology. 



•    Study the involvement of blood vessel endothelial cells with high META-79+ (presence and quantity) in skin melanoma regression and clinical evolution. 
•    Using real-time PCR and immunohistochemistry to study the expression of epithelial mesenchymal transition markers and tumor-initiating cells in human cutaneous melanoma tumor progression.
•    Study microRNA expression in samples of cutaneous melanomas using real-time PCR.