Área Oncología

Grupo de Investigación de Tumores del Sistema Nervioso Central

José Miguel Cerdá Nicolás


Grupo de Investigación de Tumores del Sistema Nervioso Central


Ana María Clari Pérez

Investigador colaborador

Concepción López Ginés
José Manuel Almerich Silla
M. Aurelia Gregori Romero
Pablo Cerdá Durán
Robert Callaghan
Rosario Gil Benso
Teresa San Miguel Díez

Investigador predoctoral

Javier Megías Vericat
Lara Navarro Cerveró
Lisandra Muñoz Hidalgo
Pedro Roldan Badia
  • Análisis de los resultados obtenidos en 140 casos de GBM del estudio clínico, neuropatológico y molecular (MLPA).
  • Análisis de los resultados obtenidos en  el estudio de microRNA de Glioblastomas multiformes.
  • Desarrollo del modelo de transfección de microRNA en Glioblastomas Multiformes. Análisis inicial de resultados.
  • Análisis de los resultados del estatus de metilación en las vías de señalización EGFR en Glioblastomas Multiformes.
  • Puesta a punto del análisis comparativo de las características moleculares de poblaciones celulares neoplasicas en GBM mediante Microdisección laser.
Número total de publicaciones: 62. Factor de Impacto acumulado: 159.24
Implication of general anaesthetic and sedation techniques in temporomandibular joint disorders - a systematic review.
Talaván-Serna J, Montiel-Company JM, Bellot-Arcís C, Almerich-Silla JM.
Journal of stomatology, oral and maxillofacial surgery. 2017 Feb. 40-44
Effectiveness of interceptive treatment of class III malocclusions with skeletal anchorage: A systematic review and meta-analysis.
Rodríguez de Guzmán-Barrera J, Sáez Martínez C, Boronat-Catalá M, Montiel-Company JM, Paredes-Gallardo V, Gandía-Franco JL, Almerich-Silla JM, Bellot-Arcís C.
PloS one. 2017. e0173875. FI: 2.806
Diagnostic validity of ICDAS and DIAGNOdent combined: an in vitro study in pre-cavitated lesions.
Iranzo-Cortés JE, Terzic S, Montiel-Company JM, Almerich-Silla JM.
Lasers in medical science.. 2017 Apr. 543-548. FI: 2.299
Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma.
Domingo-Arrué B, Gil-Benso R, Megías J, Navarro L, San-Miguel T, Muñoz-Hidalgo L, López-Ginés C, Cerdá-Nicolás M.
Current oncology. 2017 Jun. e244-e250. FI: 2.048
Association between epidermal growth factor receptor amplification and ADP-ribosylation factor 1 methylation in human glioblastoma.
López-Ginés C, Navarro L, Muñoz-Hidalgo L, Buso E, Morales JM, Gil-Benso R, Gregori-Romero M, Megías J, Roldán P, Segura-Sabater R, Almerich-Silla JM, Monleón D, Cerdá-Nicolás M.
Cellular oncology. 2017 Jun 19. . FI: 3.786
Characterization of the new human pleomorphic undifferentiated sarcoma TP53-null cell line mfh-val2.
Gil-Benso R, Megías J, San-Miguel T, Pinto S, Callaghan RC, López-Ginés C, Cerdá-Nicolás M.
Cytotechnology. 2017 Aug. 539-550. FI: 1.857
Association between duration of breastfeeding and malocclusions in primary and mixed dentition: a systematic review and meta-analysis.
Boronat-Catalá M, Montiel-Company JM, Bellot-Arcís C, Almerich-Silla JM, Catalá-Pizarro M.
Scientific reports. 2017 Jul 11. 5048. FI: 4.259
Epigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment.
Llorca-Cardeñosa MJ, Fleitas T, Ibarrola-Villava M, Peña-Chilet M, Mongort C, Martinez-Ciarpaglini C, Navarro L, Gambardella V, Castillo J, Roselló S, Navarro S, Ribas G, Cervantes A
Oncotarget. 2016 Sep 27. 63424-63436. FI: 5.168
Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice.
Giner E, Recio MC, Ríos JL, Cerdá-Nicolás JM, Giner RM
Molecular nutrition & food research.. 2016 Feb. 242-55. FI: 4.603
Effectiveness of mandibular advancement appliances in treating obstructive sleep apnea syndrome: A systematic review.
Serra-Torres S, Bellot-Arcís C, Montiel-Company JM, Marco-Algarra J, Almerich-Silla JM
The Laryngoscope.. 2016 Feb. 507-14. FI: 2.144
Effects of mandibular advancement surgery on the temporomandibular joint and muscular and articular adaptive changes-a systematic review.
Bermell-Baviera A, Bellot-Arcís C, Montiel-Company JM, Almerich-Silla JM
International journal of oral and maxillofacial surgery.. 2016 May. 545-52. FI: 1.565
Hypomineralized Second Primary Molars as Predictor of Molar Incisor Hypomineralization.
Negre-Barber A, Montiel-Company JM, Boronat-Catalá M, Catalá-Pizarro M, Almerich-Silla JM
Scientific reports.. 2016 Aug 25. 31929. FI: 5.228
Impact of functional mandibular advancement appliances on the temporomandibular joint - a systematic review.
Ivorra-Carbonell L, Montiel-Company JM, Almerich-Silla JM, Paredes-Gallardo V, Bellot-Arcís C
Medicina oral, patología oral y cirugía bucal.. 2016 Sep 1. e565-72
Orthodontic treatment need of 9, 12 and 15 year-old children according to the Index of Orthodontic Treatment Need and the Dental Aesthetic Index.
Boronat-Catalá M, Bellot-Arcís C, Montiel-Company JM, Catalá-Pizarro M, Almerich-Silla JM
Journal of orthodontics.. 2016 Apr 22. 42552
Spinal cord stimulation and failed back surgery syndrome. Clinical results with laminectomy electrodes.
García March G, Bordes V, Roldán P, Real L, González Darder JM
Neurocirugia (Asturias, Spain). 2015 Mar-Apr. 78-83. FI: 0.293
Alteration of major vault protein in human glioblastoma and its relation with EGFR and PTEN status.
Navarro L, Gil-Benso R, Megías J, Muñoz-Hidalgo L, San-Miguel T, Callaghan RC, González-Darder JM, López-Ginés C, Cerdá-Nicolás MJ
Neuroscience. 2015 Jun 25. 243-51. FI: 3.357
Case-control study of craniomandibular disorders in patients with fibromyalgia.
García-Moya EJ, Montiel-Company JM, Almerich-Silla JM
Journal of clinical and experimental dentistry. 2015 Apr. e293-8
Differences in psychological traits between lingual and labial orthodontic patients: Perfectionism, body image, and the impact of dental esthetics.
Bellot-Arcís C, Ferrer-Molina M, Carrasco-Tornero Á, Montiel-Company JM, Almerich-Silla JM
The Angle orthodontist. 2015 Jan. 58-63. FI: 1.225
Effects of mandibular setback surgery on upper airway dimensions and their influence on obstructive sleep apnoea - a systematic review.
Fernández-Ferrer L, Montiel-Company JM, Pinho T, Almerich-Silla JM, Bellot-Arcís C
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.. 2015 Mar. 248-53. FI: 2.933
Evolution to malignancy: A genetic stepwise study of tumor suppressor genes loss in a recurrent meningioma.
San-Miguel T, Cerdá-Nicolás M, Gil-Benso R, Callaghan RC, Muñoz-Hidalgo L, López-Ginés C
Clinical neuropathology. 2015 Jul-Aug. 237-9. FI: 1.528
Ewing-like sarcoma with CIC-DUX4 gene fusion in a patient with neurofibromatosis type 1. A hitherto unreported association.
Tardío JC, Machado I, Navarro L, Idrovo F, Sanz-Ortega J, Pellín A, Llombart-Bosch A
Pathology, research and practice.. 2015 Nov. 877-82. FI: 1.397
Expression of the Chemokine Receptors CXCR3, CXCR4, CXCR7 and Their Ligands in Rhabdomyosarcoma.
San-Miguel T, Pinto S, Navarro L, Callaghan RC, Monteagudo C, López-Ginés C, Cerdá-Nicolás M, Gil-Benso R
Pathology oncology research : POR.. 2015 Sep. 1191-9. FI: 1.855
Fluoride content of bottled natural mineral waters in Spain and prevention of dental caries.
Maraver F, Vitoria I, Almerich-Silla JM, Armijo F
Atencion primaria / Sociedad Española de Medicina de Familia y Comunitaria. 2015 Jan. 15-24. FI: 0.953
Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of Bacteria.
Almerich-Silla JM, Montiel-Company JM, Pastor S, Serrano F, Puig-Silla M, Dasí F
Disease markers.. 2015. 653537. FI: 1.562
Primary paraesophageal Ewing's sarcoma: an uncommon case report and literature review.
Tarazona N, Navarro L, Cejalvo JM, Gambardella V, Pérez-Fidalgo JA, Sempere A, Navarro S, Cervantes A
OncoTargets and therapy. 2015. 1053-9. FI: 2.311
Relationship between perception of malocclusion and the psychological impact of dental aesthetics in university students.
Bellot-Arcís C, Montiel-Company JM, Pinho T, Almerich-Silla JM
Journal of clinical and experimental dentistry. 2015 Feb. e18-22
Soft tissue myoepithelial carcinoma with rhabdoid-like features and EWSR1 rearrangement: Fine needle aspiration cytology with histologic correlation.
Machado I, López-Soto MV, Rubio L, Navarro L, Llombart-Bosch A
Diagnostic cytopathology. 2015 May. 421-6. FI: 1.121
Cross-sectional study of malocclusion in Spanish children.
Almerich-Silla JM, Montiel-Company JM, Bellot-Arcís C, Puertes-Fernández N
Medicina oral, patología oral y cirugía bucal. 2014 Jan 1. e15-9. FI: 1.13
Epidemiologic study of molar-incisor hypomineralization in 8-year-old Spanish children.
Garcia-Margarit M, Catalá-Pizarro M, Montiel-Company JM, Almerich-Silla JM
International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children. 2014 Jan. 14-22. FI: 1.54
Cross-cultural adaptation, validity and psychometric properties of the Spanish version of the Dental Satisfaction Questionnaire.
López-Garví AJ, Montiel-Company JM, Almerich-Silla JM
Community dental health. 2014 Mar. 44-9. FI: 0.871
Relationship of children's salivary microbiota with their caries status: a pyrosequencing study.
Gomar-Vercher S, Cabrera-Rubio R, Mira A, Montiel-Company JM, Almerich-Silla JM
Clinical oral investigations. 2014 Dec. 2087-94. FI: 2.285
Monitoring of the action of drugs in melanoma cells by dynamic laser speckle.
González-Peña RJ, Braga RA Jr, Cibrián RM, Salvador-Palmer R, Gil-Benso R, Miguel TS
Journal of biomedical optics. 2014 May. 57008. FI: 2.752
Fluoride content in tap water in Spain and prevention of dental caries.
Vitoria I, Maraver F, Almerich-Silla JM
Gaceta sanitaria / S.E.S.P.A.S. 2014 May-Jun. 255-6. FI: 1.25
Excessive fusion in cervical post-facetectomy arthrodesis.
González-Darder JM
Neurocirugía (Asturias, Spain). 2014 Sep-Oct. 244-5. FI: 0.322
Correlation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma multiforme.
Serna E, Lopez-Gines C, Monleon D, Muñoz-Hidalgo L, Callaghan RC, Gil-Benso R, Martinetto H, Gregori-Romero A, Gonzalez-Darder J, Cerda-Nicolas M
PloS one. 2014. e102927. FI: 3.534
Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
Pinto S, Martínez-Romero A, O'Connor JE, Gil-Benso R, San-Miguel T, Terrádez L, Monteagudo C, Callaghan RC
BMC cancer. 2014 Feb 22. 118. FI: 3.319
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota.
Muñoz-Hidalgo L, Lopez-Gines C, Navarro L, Callaghan RC, San Miguel T, Gil-Benso R, Quilis V, Botella L, Gonzalez-Darder J, Cerda-Nicolas M
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2014 Jul 10. e72-5. FI: 17.879
Systems Biology and immune aging.
O'Connor JE, Herrera G, Martínez-Romero A, de Oyanguren FS, Díaz L, Gomes A, Balaguer S, Callaghan RC
Immunology letters. 2014 Nov. 334-45. FI: 2.367
WITHDRAWN: Systems Biology and Immune Aging.
O'Connor JE, Herrera G, Martínez-Romero A, Oyanguren FS, Díaz L, Gomes A, Balaguer S, Callaghan RC
Immunology letters. 2014 Sep 20. . FI: 2.367
The follicular hormonal profile in low-responder patients undergoing unstimulated cycles: is it hypoandrogenic?
de Los Santos MJ, García-Laez V, Beltrán D, Labarta E, Zuzuarregui JL, Alamá P, Gámiz P, Crespo J, Bosch E, Pellicer A
Human reproduction (Oxford, England). 2013 Jan. 224-9. FI: 4.67
Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II.
Rius C, Piqueras L, González-Navarro H, Albertos F, Company C, López-Ginés C, Ludwig A, Blanes JI, Morcillo EJ, Sanz MJ
Arteriosclerosis, thrombosis, and vascular biology. 2013 Jan. 96-104. FI: 5.533
Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+ IL-10+ CD4+ T Cell Responses and Suppress Pathology in a Mouse Model of Colitis.
Ferreira I, Smyth D, Gaze S, Aziz A, Giacomin P, Ruyssers N, Artis D, Laha T, Navarro S, Loukas A, McSorley HJ
Infection and immunity. 2013 Jun. 2104-11. FI: 4.074
Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium.
Rius C, Company C, Piqueras L, Cerdá-Nicolás JM, González C, Servera E, Ludwig A, Morcillo EJ, Sanz MJ
Thorax. 2013 Feb. 177-86. FI: 8.561999999999999
Loeffler endocarditis of the left ventricle: cardiac magnetic resonance findings.
Bonanad C, Monmeneu JV, López-Lereu MP
Heart, lung & circulation. 2013 Dec. 1056-7. FI: 1.254
2013: The «Seville» document on Consensus on the Alternatives to Allogenic Blood Transfusion.
Leal-Noval SR, Muñoz M, Asuero M, Contreras E, García-Erce JA, Llau JV, Moral V, Páramo JA, Quintana M
Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria. 2013 Mayo-Junio. 209-235
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma.
Serna E, Morales JM, Mata M, Gonzalez-Darder J, San Miguel T, Gil-Benso R, Lopez-Gines C, Cerda-Nicolas M, Monleon D
PloS one. 2013. e67291. FI: 3.73
Molecular characterization and clinical impact of TMPRSS2-ERG rearrangement on prostate cancer: comparison between FISH and RT-PCR.
Fernández-Serra A, Rubio L, Calatrava A, Rubio-Briones J, Salgado R, Gil-Benso R, Espinet B, García-Casado Z, López-Guerrero JA
. 2013. 465179
Psychosocial impact of malocclusion in Spanish adolescents.
Bellot-Arcís C, Montiel-Company JM, Almerich-Silla JM
Korean journal of orthodontics. 2013 Aug. 193-200. FI: 0.537
Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair.
Cerrada I, Ruiz-Saurí A, Carrero R, Trigueros C, Dorronsoro A, Sanchez-Puelles JM, Diez-Juan A, Montero JA, Sepúlveda P
Stem cells and development. 2013 Feb 1. 501-11. FI: 4.67
Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release.
Mérida S, Sancho-Tello M, Muriach M, Miranda M, Navea A, Bosch-Morell F
Free radical research. 2013 Aug. 593-601. FI: 3.279
Invasive device-related infections after heart surgery.
Álvarez Lerma F, Carrasco M, Otal JJ, Palomar M, Olaechea P, Peris X, Iglesias L, Martínez Pellus A, Arenzana A, Ballesteros JC, Grupo de Estudio ENVIN-HELICS
Medicina intensiva / Sociedad Española de Medicina Intensiva y Unidades Coronarias. 2013 Dec. 584-92. FI: 1.323
Intracranial hypertension related to sedation with sevoflurane using the AnaConDa(®) device in a patient with severe traumatic brain injury.
Ferrando C, Carbonell JA, Aguilar G, Badenes R, Belda FJ
Revista española de anestesiología y reanimación. 2013 Oct. 472-5
Characterization of a new human melanoma cell line with CD133 expression.
Gil-Benso R, Monteagudo C, Cerdá-Nicolás M, Callaghan RC, Pinto S, Martínez-Romero A, Pellín-Carcelén A, San-Miguel T, Cigudosa JC, López-Ginés C
Human cell. 2012 Jun. 61-7. FI: 0.75
Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models.
Bodi V, Sanchis J, Morales JM, Marrachelli VG, Nunez J, Forteza MJ, Chaustre F, Gomez C, Mainar L, Minana G, Rumiz E, Husser O, Noguera I, Diaz A, Moratal D, Carratala A, Bosch X, Llacer A, Chorro FJ, Viña JR, Monleon D
Journal of the American College of Cardiology. 2012 May 1. 1629-41. FI: 14.086
Diabetes impairs the atrial natriuretic peptide relaxant action mediated by potassium channels and prostacyclin in the rabbit renal artery.
Marrachelli VG, Centeno JM, Miranda I, Castelló-Ruiz M, Burguete MC, Jover-Mengual T, Salom JB, Torregrosa G, Miranda FJ, Alborch E
Pharmacological research : the official journal of the Italian Pharmacological Society. 2012 Nov. 392-400. FI: 4.346
Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells.
Martínez-Martín N, Blas-García A, Morales JM, Marti-Cabrera M, Monleón D, Apostolova N
International journal of molecular medicine. 2012 Jan. 88-94. FI: 1.957
The use of occlusal indices in high-impact literature.
Bellot-Arcís C, Montiel-Company JM, Almerich-Silla JM, Paredes-Gallardo V, Gandía-Franco JL
Community dental health. 2012 Mar. 45-8. FI: 0.9320000000000001
Orthodontic treatment need in a Spanish young adult population.
Bellot-Arcís C, Montiel-Company JM, Manzanera-Pastor D, Almerich-Silla JM
Medicina oral, patología oral y cirugía bucal. 2012 Jul 1. e638-43. FI: 1.13
Transzygomatic pterional approach. Part 2: Surgical experience in the management of skull base pathology.
González-Darder JM, Quilis-Quesada V, Botella-Maciá L
Neurocirugía (Asturias, Spain). 2012 May. 96-103. FI: 0.343
Transzygomatic pterional approach. Part 1: anatomical study.
Quilis-Quesada V, Botella-Maciá L, González-Darder JM
Neurocirugía (Asturias, Spain). 2012 Mar. 47-53. FI: 0.343
Management of neurovascular disease in Neurosurgical Departments in Spain.
González-Darder JM
Neurocirugía (Asturias, Spain). 2012 Sep. 216-7. FI: 0.343
Metabolomic profiling in blood from umbilical cords of low birth weight newborns.
Ivorra C, García-Vicent C, Chaves FJ, Monleón D, Morales JM, Lurbe E
Journal of translational medicine. 2012 Jul 9. 142. FI: 3.459

Interacción de miRNA-200 y miRNA-138 en la infiltración y perfiles de MMMI del Glioblastoma Multiforme primario. Utilidad como biomarcadores en el diagnóstico, pronóstico y terapéutico.

Entidad financiadora:
Instituto de Salud Carlos III
01/01/2015 - 31/12/2017
Presupuesto total:

Estudio de las consecuencias de la activación de receptores TLR en cultivos celulares de glioblastoma.

Investigador principal:
José Miguel Cerdá Nicolás
Entidad financiadora:
Universidad de Valencia
01/01/2015 - 31/12/2015
Presupuesto total: