Área Metabolismo

Grupo de Investigación en envejecimiento y ejercicio físico

José Viña Ribes

El Dr. José Viña Ribes es Catedrático de Fisiología de la Universitat de València. Tras finalizar sus estudios en medicina en esta universidad, se inició en la investigación biomédica en la Universidad de Oxford, en el Medical Research Council (Consejo de Investigación Médica), bajo la dirección del Prof. Hans Krebs, obteniendo el título de doctor en 1976.

El profesor Viña es Doctor ‘honoris causa’ por la Université de Rennes 2 en Francia a propuesta del profesor Paul Delamarche, decano de la Facultad de Educación Física. También ha sido nombrado Doctor ‘honoris causa’ por la Universidad Argentina de Buenos Aires.

El Dr. Viña ha centrado sus investigaciones en el envejecimiento y los radicales libres, las enfermedades asociadas al envejecimiento como la enfermedad de Alzheimer, las alteraciones metabólicas durante el envejecimiento y la fragilidad asociada al mismo. En la actualidad investiga los genes específicos que expresan las personas centenarias y su regulación mediante dieta y ejercicio. Es el Director de la Línea de Investigación de Metabolismo y Daño Orgánico - envejecimiento y enfermedades asociadas de la Fundación INCLIVA.

 

Grupo de investigación en envejecimiento y ejercicio físico

Investigador colaborador

Andrea Salvador Pascual
Consuelo Escriva López
Esther Giraldo Reboloso
Gloria Olaso González
Marta Inglés de la Torre

Investigador predoctoral

Cristina Mas Bargues
Helena Cabo Plaza
José Viña Almunia

Línea de investigación del Alzheimer:

  • Descubrimiento de una vía de excitotoxicidad por glutamato debido al aumento de los niveles de glutaminasa.

 Línea de investigación de Ejercicio Físico:

  • Demostración del papel protector del ejercicio  físico en el tratamiento de la sarcopenia senil, así como las bases moleculares que sustentan dicha mejora 
  • Establecimiento de pautas de prescripción de ejercicio físico en la población anciana.
  • Demostración del papel protector del alopurinol en el daño muscular asociado a la práctica  del fútbol profesional.

Línea de investigación de envejecimiento:

  • Constitución grupo español para el estudio de Centenarios.
  • Publicación de la revisión de la teoría de los radicales libres del envejecimiento
Número total de publicaciones: 187. Factor de Impacto acumulado: 829.41
The weight of pupils' schoolbags in early school age and its influence on body posture
Brzek A, Dworrak T, Strauss M, Sanchis-Gomar F, Sabbah I, Dworrak B, Leischik R.
BMC musculoskeletal disorders. 2017 Mar 21. 117. FI: 1.739
Non-traumatic rhabdomyolysis: Background, laboratory features, and acute clinical management.
Cervellin G, Comelli I, Benatti M, Sanchis-Gomar F, Bassi A, Lippi G.
Clinical biochemistry. 2017 Feb 21. . FI: 2.434
Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
Danese E, Salvagno GL, Tarperi C, Negrini D, Montagnana M, Festa L, Sanchis-Gomar F, Schena F, Lippi G.
Oncotarget. 2017 Apr 18. . FI: 5.168
Early in-hospital variation of red blood cell distribution width predicts mortality in patients with acute heart failure.
Turcato G, Zorzi E, Prati D, Ricci G, Bonora A, Zannoni M, Maccagnani A, Salvagno GL, Sanchis-Gomar F, Cervellin G, Lippi G.
International journal of cardiology. 2017 May 6. . FI: 6.189
Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis.
Sweeney TE, Wynn JL, Cernada M, Serna E, Wong HR, Baker HV, Vento M, Khatri P.
Journal of the Pediatric Infectious Diseases Society.. 2017 Apr 13.
Facial alveolar bone width at the first and second maxillary premolars in healthy patients: A cone beam computed tomography study.
Rojo J, Viña J, Peñarrocha D, Peñarrocha M.
The Journal of oral implantology. 2017 Apr 19. . FI: 1.283
Exercising recommendations for paroxysmal AF in young and middle-aged athletes (PAFIYAMA) syndrome.
Perez-Quilis C, Lippi G, Cervellin G, Löllgen H, Sanchis-Gomar F.
Annals of translational medicine. 2017 Jan. 24
Benefits of skeletal-muscle exercise training in pulmonary arterial hypertension: The WHOLEi+12 trial
González-Saiz L, Fiuza-Luces C, Sanchis-Gomar F, Santos-Lozano A, Quezada-Loaiza CA, Flox-Camacho A, Munguía-Izquierdo D, Ara I, Santalla A, Morán M, Sanz-Ayan P, Escribano-Subías P, Lucia A.
International journal of cardiology. 2017 Mar 15. 277-283. FI: 6.189
AMP-activated protein kinase (AMPK) signaling pathway: A potential mechanism involved in PAFIYAMA syndrome?
Sanchis-Gomar F, Perez-Quilis C, Lippi G.
International journal of cardiology. 2017 Apr 15. 96. FI: 6.189
PPAR? modulation by GW501516: An unsuccessful exercise mimetic.
Sanchis-Gomar F, Lippi G, Perez-Quilis C.
Clinical pharmacology and therapeutics. 2017 Jan 25. . FI: 7.266
Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging
Olivieri F, Capri M, Bonafè M, Morsiani C, Jung HJ, Spazzafumo L, Viña J, Suh Y.
Mechanisms of ageing and development. 2017 Jul. 0047-6374. FI: 3.087
Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kracun D, Krause KH, Kren V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milkovic L, Miranda-Vizuete A, Mojovic M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavicevic A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanic V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçin AS, Yelisyeyeva O, Žarkovic N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A.
Redox biology. 2017 Oct 26. 2213-2317. FI: 6.337
Exercise training intensity and connexin 43 expression in hypertrophic cardiomyopathy.
Sanchis-Gomar F, Malkani K, Perez-Quilis C.
Journal of molecular and cellular cardiology. 2017 Jun 20. . FI: 5.68
Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC Randomized Trial.
Fiuza-Luces C, Padilla JR, Valentín J, Santana-Sosa E, Santos-Lozano A, Sanchis-Gomar F, Pareja-Galeano H, Morales JS, Fleck SJ, Pérez M, Lassaletta A, Soares-Miranda L, Pérez-Martínez A, Lucia A.
American journal of physical medicine & rehabilitation. 2017 Jun 21. 831-837. FI: 1.734
Accuracy of Implant Placement with Computer-Guided Surgery: A Systematic Review and Meta-Analysis Comparing Cadaver, Clinical, and In Vitro Studies
Bover-Ramos F, Viña-Almunia J, Cervera-Ballester J, Peñarrocha-Diago M, García-Mira B.
The International journal of oral & maxillofacial implants. 2017 Jun 20. 0882-2786. FI: 2.263
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kra?un D, Krause KH, K?en V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milkovi? L, Miranda-Vizuete A, Mojovi? M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavi?evi? A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepani? V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalç?n AS, Yelisyeyeva O, Žarkovi? N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A.
Redox biology. 2017 May 18. 94-162. FI: 6.337
Effectiveness of Manual Therapy Combined With Physical Therapy in Treatment of Patellofemoral Pain Syndrome: Systematic Review
Espí-López GV, Arnal-Gómez A, Balasch-Bernat M, Inglés M.
Journal of chiropractic medicine. 2017 Jun. 1556-3707
Serum Concentration of Growth Differentiation Factor-15 Is Independently Associated with Global Platelet Function and Higher Fibrinogen Values in Adult Healthy Subjects.
Lippi G, Salvagno GL, Danese E, Brocco G, Gelati M, Montagnana M, Sanchis-Gomar F, Favaloro EJ.
Seminars in thrombosis and hemostasis.. 2017 Jun 8. . FI: 3.629
Increased Cardiovascular Risk Associated With E-Cigarette Use.
Sanchis-Gomar F, Lippi G, Perez-Quilis C.
JAMA cardiology. 2017 Jun 7.
Clinical parameters of implants placed in healed sites using flapped and flapless techniques: A systematic review
Llamas-Monteagudo O, Girbés-Ballester P, Viña-Almunia J, Peñarrocha-Oltra D, Peñarrocha-Diago M.
Medicina oral, patología oral y cirugía bucal. 2017 Sep 1. 1698-4447. FI: 1.156
Influence of ABO blood group on sports performance.
Lippi G, Gandini G, Salvagno GL, Skafidas S, Festa L, Danese E, Montagnana M, Sanchis-Gomar F, Tarperi C, Schena F.
Annals of translational medicine. 2017 Jun. 255
Modulation of heart rate by acute or chronic aerobic exercise. Potential effects on blood pressure control.
Perez-Quilis C, Kingsley JD, Malkani K, Cervellin G, Lippi G, Sanchis-Gomar F.
Current pharmaceutical design. 2017 Jul 10. . FI: 2.611
Endocrinology of Aging From a Muscle Function Point of View: Results From the Toledo Study for Healthy Aging.
Guadalupe-Grau A, Carnicero JA, Losa-Reyna J, Tresguerres J, Gómez-Cabrera MD, Castillo C, Alfaro-Acha A, Rosado-Artalejo C, Rodriguez-Mañas L, García-García FJ
Journal of the American Medical Directors Association.. 2017 Mar 1. 234-239. FI: 6.616
Challenges in the analysis of epigenetic biomarkers in clinical samples.
García-Giménez JL, Mena-Mollá S, Beltrán-García J, Sanchis-Gomar F
Clinical chemistry and laboratory medicine.. 2017 Mar 16. . FI: 3.017
Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians.
Borrás C, Serna E, Gambini J, Inglés M, Vina J
Mechanisms of ageing and development.. 2017 Jul 25. . FI: 2.951
Brain-Derived Neurotrophic Factor as a Marker of Cognitive Frailty.
Inglés M, Gambini J, Mas-Bargues C, García-García FJ, Viña J, Borrás C.
The journals of gerontology. Series A, Biological sciences and medical sciences. 2017 Mar 1. 450-451. FI: 5.957
New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease.
Fuchsberger T, Lloret A, Viña J
International journal of molecular sciences. 2017 May 14. 1057. FI: 3.257
Influence of Partial O2 Pressure on the Adhesion, Proliferation, and Osteogenic Differentiation of Human Dental Pulp Stem Cells on ß-Tricalcium Phosphate Scaffold
Viña-Almunia J, Mas-Bargues C, Borras C, Gambini J, El Alami M, Sanz-Ros J, Peñarrocha M, Vina J.
International journal of oral & maxillofacial implants. 2017 November/December;32(6):1251–1256. doi: 10.11607/jomi.5529. Epub 2017 Sep 22.. 1251-1256. FI: 2.263
A stress-resistant lipidomic signature confers extreme longevity to humans.
Jové M, Naudí A, Gambini J, Borras C, Cabré R, Portero-Otín M, Viña J, Pamplona R
The journals of gerontology. Series A, Biological sciences and medical sciences.. 2017 Jan. 30-37. FI: 5.957
A new frailty score for experimental animals based on the clinical phenotype: inactivity as a model of frailty.
Gomez-Cabrera MC, Garcia-Valles R, Rodriguez-Mañas L, Garcia-Garcia FJ, Olaso-Gonzalez G, Salvador-Pascual A, Tarazona-Santabalbina FJ, Viña J
The journals of gerontology. Series A, Biological sciences and medical sciences.. 2017 Jan 19. . FI: 5.957
Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
Mas-Bargues C, Viña-Almunia J, Inglés M, Sanz-Ros J, Gambini J, Ibáñez-Cabellos JS, García-Giménez JL, Viña J, Borrás C
Redox biology.. 2017 Apr 7. 690-698. FI: 6.235
Reply from Mari Carmen Gomez-Cabrera and Jose Viña.
Gomez-Cabrera MC, Viña J
The Journal of physiology.. 2017 Aug 15. 5715. FI: 4.344
Ultrasonic Echo Intensity as a New Noninvasive In Vivo Biomarker of Frailty.
Mirón Mombiela R, Facal de Castro F, Moreno P, Borras C
Journal of the American Geriatrics Society.. 2017 Sep 7. . FI: 4.388
Detection of cardiovascular calcifications: Is it a useful tool for nephrologists?
Bover J, Górriz JL, Ureña-Torres P, Lloret MJ, Ruiz-García C, daSilva I, Chang P, Rodríguez M, Ballarín J
Nefrología. 2016 Nov - Dec. 587-596. FI: 1.183
Endopelvic free anchor minisling technique for stress urinary incontinence treatment: 10 years of experience
Gambini-Ricapa J, García-Oms J, Barea M, Estrada A, Iturri A, Gambini-Buchon J, Gilabert-Estelles J.
International Urogynecology Journal. 2016 Aug;27(8):1265-72. doi: 10.1007/s00192-016-2958-z. Epub 2016 Feb 10.. 1265-72. FI: 1.937
Cardiovascular calcifications in chronic kidney disease: Potential therapeutic implications
Bover J, Ureña-Torres P, Górriz JL, Lloret MJ, da Silva I, Ruiz-García C, Chang P, Rodríguez M, Ballarín J
Nefrología. 2016 Nov - Dec. 597-608. FI: 1.183
Biology of frailty: modulation of ageing genes and its importance to prevent age-associated loss of function.
Viña J, Tarazona-Santabalbina FJ, Pérez-Ros P, Martínez-Arnau FM, Borras C, Olaso-Gonzalez G, Salvador-Pascual A, Gomez-Cabrera MC
Molecular aspects of medicine.. 2016 Aug. 88-108. FI: 10.238
Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease.
Bonet-Costa V, Herranz-Pérez V, Blanco-Gandía M, Mas-Bargues C, Inglés M, Garcia-Tarraga P, Rodriguez-Arias M, Miñarro J, Borras C, Garcia-Verdugo JM, Viña J
Journal of Alzheimer's disease : JAD.. 2016 Feb 10. 701-11. FI: 4.151
Exercise training as a drug to treat age associated frailty.
Viña J, Salvador-Pascual A, Tarazona-Santabalbina FJ, Rodriguez-Mañas L, Gomez-Cabrera MC
Free radical biology & medicine.. 2016 Sep. 159-64. FI: 5.736
Influence of different types of pulp treatment during isolation in the obtention of human dental pulp stem cells
Viña-Almunia J, Borras C, Gambini J, El Alamy M, Peñarrocha M, Viña J
Medicina oral, patología oral y cirugía bucal. 2016 May 1. e374-9. FI: 1.156
Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging.
Borras C, Abdelaziz KM, Gambini J, Serna E, Inglés M, de la Fuente M, Garcia I, Matheu A, Sanchís P, Belenguer A, Errigo A, Avellana JA, Barettino A, Lloret-Fernández C, Flames N, Pes G, Rodriguez-Mañas L, Viña J
Aging. 2016 Oct 28. 3185-3208. FI: 3.979
Reductive Stress: A New Concept in Alzheimer's Disease.
Lloret A, Fuchsberger T, Giraldo E, Vina J
Current Alzheimer research.. 2016. 206-11. FI: 3.889
Role of NAD(+)/NADH redox ratio in cell metabolism: A tribute to Helmut Sies and Theodor Bücher and Hans A. Krebs.
Viña J, Saez GT, Gambini J, Gomez-Cabrera MC, Borrás C
Archives of biochemistry and biophysics.. 2016 Apr 1. 176-80. FI: 3.017
Aβ Induces excitotoxicity mediated by apc/c-cdh1 depletion that can be prevented by glutaminase inhibition promoting neuronal survival.
Fuchsberger T, Martínez-Bellver S, Giraldo E, Teruel-Martí V, Lloret A, Viña J
Scientific reports.. 2016 Aug 12. 31158. FI: 4.259
Active paraplegics are protected against exercise-induced oxidative damage through the induction of antioxidant enzymes.
Inglés M, Serra-Añó P, Gambini J, Abu-Sharif F, Dromant M, Garcia-Valles R, Pareja-Galeano H, Garcia-Lucerga C, Gomez-Cabrera MC
Spinal cord series and cases.. 2016 Oct. 830-837. FI: 1.804
Identification of single nucleotide polymorphisms in centenarians.
Gambini J, Gimeno-Mallench L, Inglés M, Olaso G, Abdelaziz KM, Avellana JA, Belenguer Á, Cruz R, Mas-Bargues C, Borras C, Viña J
Revista española de geriatría y gerontología.. 2016 May-Jun. 146-9
Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients.
Di Domenico F, Pupo G, Giraldo E, Badìa MC, Monllor P, Lloret A, Schininà ME, Giorgi A, Cini C, Tramutola A, Butterfield DA, Viña J, Perluigi M
Free radical biology & medicine.. 2016 Feb. 43344. FI: 5.736
A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial.
Tarazona-Santabalbina FJ, Gómez-Cabrera MC, Pérez-Ros P, Martínez-Arnau FM, Cabo H, Tsaparas K, Salvador-Pascual A, Rodriguez-Mañas L, Viña J
Journal of the American Medical Directors Association.. 2016 May 1. 426-33. FI: 4.939
Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: potential pathogenic role and link to oxidative damage.
Di Domenico F, Pupo G, Giraldo E, Lloret A, Badia MC, Schinina ME, Giorgi A, Butterfield DA, Vina J, Perluigi M
Current Alzheimer research.. 2016. 112-22. FI: 3.889
Disinfection by-products effect on swimmers oxidative stress and respiratory damage.
Llana-Belloch S, Priego Quesada JI, Pérez-Soriano P, Lucas-Cuevas ÁG, Salvador-Pascual A, Olaso-González G, Moliner-Martinez Y, Verdú-Andres J, Campins-Falco P, Gómez-Cabrera MC
European journal of sport science. 2016 Aug. 609-17. FI: 1.55
Editorial Olympic 2016 Special Issue "Human performance and redox signaling in health and disease".
Viña J, Gomez-Cabrera MC, J Jackson M
Free radical biology & medicine. 2016 Jun 6. . FI: 5.736
Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty.
Viña J, Rodriguez-Mañas L, Salvador-Pascual A, Tarazona-Santabalbina FJ, Gomez-Cabrera MC
The Journal of physiology.. 2016 Apr 15. 1989-99. FI: 5.037
G6PD protects from oxidative damage and improves healthspan in mice.
Nóbrega-Pereira S, Fernandez-Marcos PJ, Brioche T, Gomez-Cabrera MC, Salvador-Pascual A, Flores JM, Viña J, Serrano M
Nature communications. 2016 Mar 15. 10894. FI: 12.124
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.
Traylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, Barrick TR, Moynihan B, Lewis CM, Boncoraglio GB, Lemmens R, Thijs V, Sudlow C, Wardlaw J, Rothwell PM, Meschia JF, Worrall BB, Levi C, Bevan S, Furie KL, Dichgans M, Rosand J, Markus HS, Rost N, International Stroke Genetics Consortium
Neurology.. 2016 Jan 12. 146-53. FI: 8.286
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
GBD 2015 Risk Factors Collaborators.
Lancet. 2016 Oct 8;388(10053):1659-1724. doi: 10.1016/S0140-6736(16)31679-8.. 1659-1724. FI: 47.831
ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups.
Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung KS, Corrada MM, Crawford JD, Daly C, Gondo Y, Hagberg B, Hirose N, Holstege H, Kawas C, Kaye J, Kochan NA, Lau BH, Lucca U, Marcon G, Martin P, Poon LW, Richmond R, Robine JM, Skoog I, Slavin MJ, Szewieczek J, Tettamanti M, Viña J, Perls T, Sachdev PS
BMC neurology. 2016 Apr 21. 52. FI: 2.04
In Search of 'Omics'-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative.
Erusalimsky JD, Grillari J, Grune T, Jansen-Duerr P, Lippi G, Sinclair AJ, Tegnér J, Viña J, Durrance-Bagale A, Miñambres R, Viegas M, Rodríguez-Mañas L, FRAILOMIC Consortium
Gerontology.. 2016. 182-90. FI: 3.059
Olympic Genes on the Podium?
Sanchis-Gomar F, Galeano HP, Rodriguez-Marroyo JA, de Koning JJ, Lucia A, Foster C
International journal of sports physiology and performance.. 2016 Oct 13. 42583. FI: 3.042
PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.
Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA
Nature neuroscience.. 2016 Mar. 443-53. FI: 16.095
Molecular mechanisms linking amyloid ? toxicity and Tau hyperphosphorylation in Alzheimer?s disease.
Lloret A, Fuchsberger T, Giraldo E, Viña J
Free radical biology & medicine. 2015 Mar 5. 186-191. FI: 5.736
Oxidative stress and longevity; a case-control study.
Belenguer Varea Á, Mohamed Abdelaziz K, Avellana Zaragoza JA, Borrás Blasco C, Sanchis Aguilar P, Viña Ribes J
Revista española de geriatría y gerontología.. 2015 Jan-Feb. 16-21
Allopurinol prevents cardiac and skeletal muscle damage in professional soccer players.
Sanchis-Gomar F, Pareja-Galeano H, Gomez-Cabrera MC, Candel J, Lippi G, Salvagno GL, Mann GE, Viña J
Scandinavian journal of medicine & science in sports. 2015 Feb. e110-5. FI: 2.896
Effect of exhaustive running exercise on red blood cell distribution width.
Alis R, Romagnoli M, Primo-Carrau C, Pareja-Galeano H, Blesa JR, Sanchis-Gomar F
Clinical chemistry and laboratory medicine : CCLM / FESCC. 2015 Feb 1. e29-31. FI: 2.707
Effects of allopurinol on exercise-induced muscle damage: new therapeutic approaches?
Sanchis-Gomar F, Pareja-Galeano H, Perez-Quilis C, Santos-Lozano A, Fiuza-Luces C, Garatachea N, Lippi G, Lucia A
Cell stress & chaperones. 2015 Jan. 41334. FI: 3.163
Effects of an acute high-intensity interval training protocol on plasma viscosity.
Alis R, Ibañez-Sania S, Basterra J, Sanchis-Gomar F, Romagnoli M
The Journal of sports medicine and physical fitness. 2015 Jun. 647-53. FI: 0.972
Even free radicals should follow some rules: A Guide to free radical research terminology and methodology.
Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ 2nd, Vina J, Davies KJ
Free radical biology & medicine. 2015 Jan. 233-5. FI: 5.736
Hemoconcentration induced by exercise: Revisiting the Dill and Costill equation.
Alis R, Sanchis-Gomar F, Primo-Carrau C, Lozano-Calve S, Dipalo M, Aloe R, Blesa JR, Romagnoli M, Lippi G
Scandinavian journal of medicine & science in sports.. 2015 Dec. e630-7. FI: 2.896
Laboratory biomarkers and frailty: presentation of the FRAILOMIC initiative.
Lippi G, Jansen-Duerr P, Viña J, Durrance-Bagale A, Abugessaisa I, Gomez-Cabrero D, Tegnér J, Grillari J, Erusalimsky J, Sinclair A, Rodriguez-Manãs L, FRAILOMIC consortium
Clinical chemistry and laboratory medicine.. 2015 Sep 1. e253-5. FI: 2.707
Methodological considerations to determine the effect of exercise on brain-derived neurotrophic factor levels.
Pareja-Galeano H, Alis R, Sanchis-Gomar F, Cabo H, Cortell-Ballester J, Gomez-Cabrera MC, Lucia A, Viña J
Clinical biochemistry. 2015 Feb. 162-6. FI: 2.275
Oxidant antioxidants and adaptive responses to exercise.
Venditti P, Gomez-Cabrera MC, Zhang Y, Radak Z
Oxidative medicine and cellular longevity. 2015. 290190. FI: 3.516
Physical activity and depression: type of exercise matters.
Pareja-Galeano H, Sanchis-Gomar F, Lucia A
JAMA pediatrics. 2015 Mar 1. 288-9. FI: 7.148
Physical inactivity and low fitness deserve more attention to alter cancer risk and prognosis.
Sanchis-Gomar F, Lucia A, Yvert T, Ruiz-Casado A, Pareja-Galeano H, Santos-Lozano A, Fiuza-Luces C, Garatachea N, Lippi G, Bouchard C, Berger NA
Cancer prevention research (Philadelphia, Pa.). 2015 Feb. 105-10. FI: 4.444
Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans.
Gambini J, Inglés M, Olaso G, Lopez-Grueso R, Bonet-Costa V, Gimeno-Mallench L, Mas-Bargues C, Abdelaziz KM, Gomez-Cabrera MC, Vina J, Borras C
Oxidative medicine and cellular longevity. 2015. 837042. FI: 3.516
Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training?
Gomez-Cabrera MC, Salvador-Pascual A, Cabo H, Ferrando B, Viña J
Free radical biology & medicine.. 2015 Sep. 37-46. FI: 5.736
Response to vidal and colleagues.
Viña J, Inglés M, Borrás C
Journal of the American Geriatrics Society. 2015 Apr. 838-9. FI: 4.572
Serum Copeptin and Midregion Proadrenomedullin (MR-proADM) After an Ultramarathon.
Lippi G, Schena F, Salvagno GL, Sanchis-Gomar F, Guidi GC
Journal of clinical laboratory analysis. 2015 Jan. 15-20. FI: 1.038
Strenuous endurance exercise and right ventricular systolic function: no evidence of long-term sequelae.
Sanchis-Gomar F, Garatachea N, Catalán P, López M, Lucia A, Serrano-Ostáriz E
International journal of cardiology. 2015 Jan 20. 297-8. FI: 4.036
A? and tau toxicities in Alzheimer's are linked via oxidative stress-induced p38 activation: protective role of vitamin E.
Giraldo E, Lloret A, Fuchsberger T, Viña J
Redox biology. 2014. 873-7
Acetaminophen and sport performance: doping or what?
Lippi G, Sanchis-Gomar F
European journal of applied physiology. 2014 Apr. 881-2. FI: 2.298
Activation of p38, p21, and NRF-2 mediates decreased proliferation of human dental pulp stem cells cultured under 21% O2.
El Alami M, Viña-Almunia J, Gambini J, Mas-Bargues C, Siow RC, Peñarrocha M, Mann GE, Borrás C, Viña J
Stem cell reports. 2014 Oct 14. 566-73. FI: 5.365
Altitude exposure in sports: the Athlete Biological Passport standpoint.
Sanchis-Gomar F, Pareja-Galeano H, Brioche T, Martinez-Bello V, Lippi G
Drug testing and analysis. 2014 Mar. 190-3. FI: 2.816
Application of mesenchymal stem cells in bone regenerative procedures in oral implantology. A literature review.
Viña JA, El-Alami M, Gambini J, Borras C, Viña J, Peñarrocha MA
Journal of clinical and experimental dentistry. 2014 Feb. e60-e65
Association between irisin and homocysteine in euglycemic and diabetic subjects.
Alis R, Sanchis-Gomar F, Pareja-Galeano H, Hernández-Mijares A, Romagnoli M, Víctor VM, Rocha M
Clinical biochemistry. 2014 Dec. 333-5. FI: 2.229
Biological markers in older people at risk of mobility limitations.
Lippi G, Sanchis-Gomar F, Montagnana M
Current pharmaceutical design. 2014. 3222-44. FI: 3.288
Blood rheology effect of submaximal exercise on young subjects.
Romagnoli M, Alis R, Martinez-Bello V, Sanchis-Gomar F, Aranda R, Gómez-Cabrera MC
Clinical hemorheology and microcirculation. 2014 Jan 1. 111-7. FI: 2.242
Circulating irisin levels are not correlated with BMI, age, and other biological parameters in obese and diabetic patients.
Sanchis-Gomar F, Alis R, Pareja-Galeano H, Sola E, Victor VM, Rocha M, Hernández-Mijares A, Romagnoli M
Endocrine. 2014 Aug. 674-7. FI: 3.527
Correcting loss of a papilla following orthodontic space opening (Atherton´s patch) through implant supported rehabilitation. A case report.
Viña J, Balaguer J, Martorell L, Peñarrocha M
Academic medicine : journal of the Association of American Medical Colleges. 2014 Feb. e100-3
Early, but not late onset estrogen replacement therapy prevents oxidative stress and metabolic alterations caused by ovariectomy.
López-Grueso R, Gambini J, Abdelaziz KM, Monleón D, Díaz A, El Alami M, Bonet-Costa V, Borrás C, Viña J
Antioxidants & redox signaling. 2014 Jan 10. 236-46. FI: 7.407
Elite athletes live longer than the general population: a meta-analysis.
Garatachea N, Santos-Lozano A, Sanchis-Gomar F, Fiuza-Luces C, Pareja-Galeano H, Emanuele E, Lucia A
Mayo Clinic proceedings. Mayo Clinic. 2014 Sep. 1195-200. FI: 5.812
Exome sequencing of three cases of familial exceptional longevity.
Cash TP, Pita G, Domínguez O, Alonso MR, Moreno LT, Borrás C, Rodríguez-Mañas L, Santiago C, Garatachea N, Lucia A, Avellana JA, Viña J, González-Neira A, Serrano M
Aging cell. 2014 Dec. 1087-90. FI: 6.34
Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: improvement of protein balance and of antioxidant defenses.
Brioche T, Kireev RA, Cuesta S, Gratas-Delamarche A, Tresguerres JA, Gomez-Cabrera MC, Viña J
The journals of gerontology. Series A, Biological sciences and medical sciences. 2014 Oct. 1186-98. FI: 5.416
How does the journal impact factor affect the CV of PhD students?
Sanchis-Gomar F
EMBO reports. 2014 Mar. 207. FI: 7.858
Immunoglobulin E (IgE) and ischemic heart disease. Which came first, the chicken or the egg?
Lippi G, Cervellin G, Sanchis-Gomar F
Annals of medicine. 2014 Nov. 456-63. FI: 4.733
Inactivity-induced oxidative stress: a central role in age-related sarcopenia?
Derbré F, Gratas-Delamarche A, Gómez-Cabrera MC, Viña J
European journal of sport science. 2014. S98-108. FI: 1.55
Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study.
Gimeno A, García-Giménez JL, Audí L, Toran N, Andaluz P, Dasí F, Viña J, Pallardó FV
Biochimica et biophysica acta. 2014 Jan. 116-25
Influence of occlusal loading on peri-implant clinical parameters. A pilot study.
Pellicer-Chover H, Viña-Almunia J, Romero-Millán J, Peñarrocha-Oltra D, García-Mira B, Peñarrocha-Diago MA
Medicina oral, patología oral y cirugía bucal. 2014 May 1. e302-7
Influence of training and a maximal exercise test in analytical variability of muscular, hepatic, and cardiovascular biochemical variables.
Romagnoli M, Alis R, Aloe R, Salvagno GL, Basterra J, Pareja-Galeano H, Sanchis-Gomar F, Lippi G
Scandinavian journal of clinical and laboratory investigation. 2014 Apr. 192-8. FI: 2.009
Inhibition of xanthine oxidase and exercise on serum uric acid, 25(OH)D3, and calcium concentrations.
Sanchis-Gomar F, Salvagno GL, Lippi G
Clinical laboratory. 2014. 1409-11. FI: 1.084
Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats.
Kireev RA, Vara E, Viña J, Tresguerres JA
Age (Dordrecht, Netherlands). 2014 Oct. 9707. FI: 3.445
Metabolomic analysis of long-term spontaneous exercise in mice suggests increased lipolysis and altered glucose metabolism when animals are at rest.
Monleon D, Garcia-Valles R, Morales JM, Brioche T, Olaso-Gonzalez G, Lopez-Grueso R, Gomez-Cabrera MC, Viña J
Journal of applied physiology (Bethesda, Md. : 1985). 2014 Nov 15. 1110-9. FI: 3.056
Erythropoietin and the heart: Physiological effects and the therapeutic perspective.
Sanchis-Gomar F, Garcia-Gimenez JL, Pareja-Galeano H, Romagnoli M, Perez-Quilis C, Lippi G
International journal of cardiology. 2014 Feb 1. 116-25. FI: 6.175
Inconsistency in circulating irisin levels: what is really happening?
Sanchis-Gomar F, Alis R, Pareja-Galeano H, Romagnoli M, Perez-Quilis C
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme. 2014 Jul. 591-6. FI: 2.038
Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches.
Sanchis-Gomar F, Garcia-Gimenez JL, Gomez-Cabrera MC, Pallardo FV
Current pharmaceutical design. 2014. 5619-33. FI: 3.452
Mitochondrial fission and fusion in human diseases.
Sanchis-Gomar F, Derbré F
The New England journal of medicine. 2014 Mar 13. 1073-4. FI: 54.42
New molecular targets and lifestyle interventions to delay aging sarcopenia.
Sanchis-Gomar F, Pareja-Galeano H, Mayero S, Perez-Quilis C, Lucia A
Frontiers in aging neuroscience. 2014. 156. FI: 2.843
FORUM ISSUE: "Free radicals and physical exercise".
Vina J, Gomez-Cabrera MC
Free radical research. 2014 Jan. 43132. FI: 2.976
Prevalence of sarcopenia in geriatric outpatients and nursing homes. The ELLI study.
Osuna-Pozo CM, Serra-Rexach JA, Viña J, Gómez-Cabrera Mdel C, Salvá A, Ruiz D, Masanes F, Lopez-Soto A, Formiga F, Cuesta F, Cruz-Jentoft A
Revista española de geriatría y gerontología. 2014 Mar-Apr. 72-6
Allopurinol and its role in the treatment of sarcopenia.
Ferrando B, Olaso-Gonzalez G, Sebastia V, Viosca E, Gomez-Cabrera MC, Viña J
Revista española de geriatría y gerontología. 2014 Nov-Dec. 292-8
'Olympic' centenarians: Are they just biologically exceptional?
Sanchis-Gomar F, Pareja-Galeano H, Lucía A
International journal of cardiology. 2014 Jul 15. 216-7. FI: 6.175
Oxidative stress is related to frailty, not to age or sex, in a geriatric population: lipid and protein oxidation as biomarkers of frailty.
Inglés M, Gambini J, Carnicero JA, García-García FJ, Rodríguez-Mañas L, Olaso-González G, Dromant M, Borrás C, Viña J
Journal of the American Geriatrics Society. 2014 Jul. 1324-8. FI: 4.572
Pharmacological properties of physical exercise in the elderly.
Vina J, Borras C, Sanchis-Gomar F, Martinez-Bello VE, Olaso-Gonzalez G, Gambini J, Ingles M, Gomez-Cabrera MC
Current pharmaceutical design. 2014. 3019-29. FI: 3.452
Physical activity - an important preanalytical variable.
Sanchis-Gomar F, Lippi G
Biochemia medica : ?asopis Hrvatskoga društva medicinskih biokemi?ara / HDMB. 2014. 68-79. FI: 2.4
Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.
García-Mesa Y, Pareja-Galeano H, Bonet-Costa V, Revilla S, Gómez-Cabrera MC, Gambini J, Giménez-Llort L, Cristòfol R, Viña J, Sanfeliu C
Psychoneuroendocrinology. 2014 Jul. 154-66. FI: 4.944
Prevention of acute skeletal muscle wasting in critical illness.
Sanchis-Gomar F, Pareja-Galeano H, Cortell-Ballester J, Perez-Quilis C
Minerva anestesiologica. 2014 Jun. 748. FI: 2.272
Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes.
Emanuele E, Bertona M, Sanchis-Gomar F, Pareja-Galeano H, Lucia A
Biomedical reports. 2014 Sep. 755-759
PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations.
Inglés M, Gambini J, Miguel MG, Bonet-Costa V, Abdelaziz KM, El Alami M, Viña J, Borrás C
BioMed research international. 2014. 580852. FI: 1.579
PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study.
Garatachea N, Fuku N, He ZH, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Venturini L, Santiago C, Santos-Lozano A, Rodríguez G, Ricevuti G, Pareja-Galeano H, Sanchis-Gomar F, Emanuele E, Hirose N, Lucia A
Rejuvenation research. 2014 Oct. 430-8. FI: 3.931
Roles of sedentary aging and lifelong physical activity in exchange of glutathione across exercising human skeletal muscle.
Nyberg M, Mortensen SP, Cabo H, Gomez-Cabrera MC, Viña J, Hellsten Y
Free radical biology & medicine. 2014 May 22. 166-173. FI: 5.71
Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity.
Emanuele E, Minoretti P, Pareja-Galeano H, Sanchis-Gomar F, Garatachea N, Lucia A
The American journal of medicine. 2014 Sep. 888-90. FI: 5.302
Strenuous exercise and the heart: Are we not seeing the wood for the trees?
Sanchis-Gomar F, Pareja-Galeano H, Santos-Lozano A, Fiuza-Luces C, Garatachea N, Lucia A
International journal of cardiology. 2014 Oct 20. 1304-5. FI: 6.175
The hMTH1 paradox: antioxidants recommended in cancer?
Sanchis-Gomar F, Pareja-Galeano H, Lucía A
DNA repair. 2014 Sep. 163-4. FI: 3.362
Physical exercise and epigenetic modulation: elucidating intricate mechanisms.
Pareja-Galeano H, Sanchis-Gomar F, García-Giménez JL
Sports medicine (Auckland, N.Z.). 2014 Apr. 429-36. FI: 5.32
The p38-PGC-1?-irisin-betatrophin axis: Exploring new pathways in insulin resistance.
Sanchis-Gomar F, Perez-Quilis C
Adipocyte. 2014 Jan 1. 67-8
Anemia, heart failure and exercise training.
Sanchis-Gomar F, Banfi G, Pareja-Galeano H, Martinez-Bello V, Lippi G
International journal of cardiology. 2013 May 25. 587-8. FI: 5.509
Antiplatelet therapy in marathon runners: more harm than benefits?
Lippi G, Sanchis-Gomar F, Cervellin G
The American journal of medicine. 2013 Mar. e19. FI: 4.768
Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk.
de Onis M, Martínez-Costa C, Núñez F, Nguefack-Tsague G, Montal A, Brines J
Public health nutrition. 2013 Apr. 625-30. FI: 2.25
Efficacy of combination therapy with angiotensin-converting enzyme inhibitor and calcium channel blocker in hypertension.
Redón J, Trenkwalder PR, Barrios V
Expert opinion on pharmacotherapy. 2013 Feb. 155-64. FI: 2.86
Endothelial dysfunction in morbid obesity.
Mauricio MD, Aldasoro M, Ortega J, Vila JM
Current pharmaceutical design. 2013. 5718-29. FI: 3.311
Erythropoietin Receptor (EpoR) Agonism Is Used to Treat a Wide Range of Disease.
Sanchis-Gomar F, Perez-Quilis C, Lippi G
Molecular medicine (Cambridge, Mass.). 2013 Apr 30. 62-4. FI: 4.469
Evaluation and Clinical Analyses of Downstream Targets of the Akt Inhibitor GDC-0068.
Yan Y, Serra V, Prudkin L, Scaltriti M, Murli S, Rodríguez O, Guzman M, Sampath D, Nannini M, Xiao Y, Wagle MC, Wu JQ, Wongchenko M, Hampton G, Ramakrishnan V, Lackner MR, Saura C, Roda D, Cervantes A, Tabernero J, Patel P, Baselga J
Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Dec 15. 6976-86. FI: 7.837
Exercise as an adjuvant intervention in opiate dependence.
Pareja-Galeano H, Sanchis-Gomar F, Mayero S
Substance abuse : official publication of the Association for Medical Education and Research in Substance Abuse. 2013 Apr-Jun. 87-8. FI: 1.245
Hemoglobin Point-of-Care Testing: The HemoCue System.
Sanchis-Gomar F, Cortell-Ballester J, Pareja-Galeano H, Banfi G, Lippi G
Journal of laboratory automation. 2013 Jun. 198-205. FI: 1.457
Histone h3 glutathionylation in proliferating Mammalian cells destabilizes nucleosomal structure.
García-Giménez JL, Olaso G, Hake SB, Bönisch C, Wiedemann SM, Markovic J, Dasí F, Gimeno A, Pérez-Quilis C, Palacios O, Capdevila M, Viña J, Pallardó FV
Antioxidants & redox signaling. 2013 Oct 20. 1305-20. FI: 7.189
Human leukocyte/endothelial cell interactions and mitochondrial dysfunction in type 2 diabetic patients and their association with silent myocardial ischemia.
Hernandez-Mijares A, Rocha M, Rovira-Llopis S, Bañuls C, Bellod L, de Pablo C, Alvarez A, Roldan-Torres I, Sola-Izquierdo E, Victor VM
Diabetes care. 2013 Jun. 1695-702. FI: 7.735
In vivo strategies for drug discovery in myotonic dystrophy disorders.
Garcia-Alcover I, López Castel A, Perez-Alonso M, Artero R
Drug discovery today. Technologies. 2013 Spring. e97-102
Intravenous busulfan and melphalan as a conditioning regimen for autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: a matched comparison to a melphalan-only approach.
Blanes M, Lahuerta JJ, González JD, Ribas P, Solano C, Alegre A, Bladé J, San Miguel JF, Sanz MA, de la Rubia J
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Jan. 69-74. FI: 3.94
Sugammadex, a neuromuscular blockade reversal agent, causes neuronal apoptosis in primary cultures.
Palanca JM, Aguirre-Rueda D, Granell MV, Aldasoro M, Garcia A, Iradi A, Obrador E, Mauricio MD, Vila J, Gil-Bisquert A, Valles SL
International journal of medical sciences. 2013 Aug 3. 1278-85. FI: 2.065
Impact of exercise training on neuroplasticity-related growth factors in adolescents.
Pareja-Galeano H, Brioche T, Sanchis-Gomar F, Montal A, Jovaní C, Martínez-Costa C, Gomez-Cabrera MC, Viña J
Journal of musculoskeletal & neuronal interactions. 2013 Sep. 330-3. FI: 2.453
Effects of acute exercise and allopurinol administration on soluble urokinase plasminogen activator receptor (suPAR).
Sanchis-Gomar F, Bonaguri C, Pareja-Galeano H, Gomez-Cabrera MC, Candel J, Viña J, Lippi G
Clinical laboratory. 2013. 207-10. FI: 1.084
Effects of acute exercise and xanthine oxidase inhibition on novel cardiovascular biomarkers.
Sanchis-Gomar F, Bonaguri C, Aloe R, Pareja-Galeano H, Martinez-Bello V, Gomez-Cabrera MC, Candel J, Viña J, Lippi G
Translational research : the journal of laboratory and clinical medicine. 2013 Aug. 102-9. FI: 4.044
New insights into insulin resistance, cardiovascular diseases and oxidative stress: pathophysiological and clinical consequences.
Victor VM
Current pharmaceutical design. 2013. 5661-2. FI: 3.311
Role of angiotensin II in arterial pressure and renal hemodynamics in rats with altered renal development: age- and sex-dependent differences.
Reverte V, Tapia A, Baile G, Gambini J, Gíménez I, Llinas MT, Salazar FJ
American journal of physiology. Renal physiology. 2013 Jan. F33-40. FI: 3.3
Lymphocytes from Young Healthy Persons Carrying the ApoE4 Allele Overexpress Stress-Related Proteins Involved in the Pathophysiology of Alzheimer's Disease.
Badia MC, Lloret A, Giraldo E, Dasí F, Olaso G, Alonso MD, Viña J
Journal of Alzheimer's disease : JAD. 2013 Jan 1. 77-83. FI: 3.612
M2 Macrophages Activate WNT Signaling Pathway in Epithelial Cells: Relevance in Ulcerative Colitis.
Cosín-Roger J, Ortiz-Masiá D, Calatayud S, Hernández C, Alvarez A, Hinojosa J, Esplugues JV, Barrachina MD
PloS one. 2013 Oct 22. e78128. FI: 3.73
MicroRNAs miR-30b, miR-30d, and miR-494 regulate human endometrial receptivity.
Altmäe S, Martinez-Conejero JA, Esteban FJ, Ruiz-Alonso M, Stavreus-Evers A, Horcajadas JA, Salumets A
Reproductive sciences (Thousand Oaks, Calif.). 2013 Mar. 308-17. FI: 2.064
Outcome of patients with syncope beyond the implantable loop recorder.
Merlos P, Rumiz E, Ruiz-Granell R, Martínez A, Izquierdo MT, Ferrero A, Dominguez E, Sánchez JM, Morell S, García-Civera R
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2013 Jan. 122-6. FI: 2.765
Overweight, obesity, and all-cause mortality.
Viña J, Borras C, Gomez-Cabrera MC
JAMA : the journal of the American Medical Association. 2013 Apr 24. 1679. FI: 30.387
Potential role of physiotherapists in polymedication of the elderly.
Inglés M, Gambini J, Villaplana L
Geriatrics & gerontology international. 2013 Oct. 1086-7. FI: 1.575
Paraoxonase-1 Deficiency Is Associated with Severe Liver Steatosis in Mice Fed a High-fat High-cholesterol Diet: A Metabolomic Approach.
García-Heredia A, Kensicki E, Mohney RP, Rull A, Triguero I, Marsillach J, Tormos C, Mackness B, Mackness M, Shih DM, Pedro-Botet J, Joven J, Sáez G, Camps J
Journal of proteome research. 2013 Apr 5. 1946-55. FI: 5.056
Rationalizing the use of PPIs: An unresolved matter.
Ponce J, Esplugues JV
Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva. 2013 May. 121-124. FI: 1.652
Reductive stress in young healthy individuals at risk of Alzheimer disease.
Badía MC, Giraldo E, Dasí F, Alonso D, Lainez JM, Lloret A, Viña J
Free radical biology & medicine.. 2013 Oct. 274-9. FI: 5.71
Rest heart rate and mortality: more physical exercise for the rabbit?
Lippi G, Sanchis-Gomar F, Cervellin G
International journal of cardiology. 2013 May 10. 358. FI: 5.509
Resveratrol: distribution, properties and perspectives.
Gambini J, López-Grueso R, Olaso-González G, Inglés M, Abdelazid K, El Alami M, Bonet-Costa V, Borrás C, Viña J
Revista española de geriatría y gerontología. 2013 Mar-Apr. 79-88
Sestrins: novel antioxidant and AMPK-modulating functions regulated by exercise?
Sanchis-Gomar F
Journal of cellular physiology. 2013 Aug. 1647-50. FI: 4.218
The free radical theory of aging revisited: the cell signaling disruption theory of aging.
Viña J, Borras C, Abdelaziz KM, Garcia-Valles R, Gomez-Cabrera MC
Antioxidants & redox signaling. 2013 Sep 10. 779-87. FI: 7.667
Venous thrombosis associated with HMG-CoA reductase inhibitors.
Lippi G, Favaloro EJ, Sanchis-Gomar F
Seminars in thrombosis and hemostasis. 2013 Jul. 515-32. FI: 4.216
Nutrition status on pediatric admissions in Spanish hospitals; DHOSPE study.
Moreno Villares JM, Varea Calderón V, Bousoño García C, Lama Moré R, Redecillas Ferreiro S, Peña Quintana L, Sociedad Española de Gastroenterología
Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral. 2013 May-Jun. 709-18. FI: 1.305
Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project
Rodríguez-Mañas L, Féart C, Mann G, Viña J, Chatterji S, Chodzko-Zajko W, Gonzalez-Colaço Harmand M, Bergman H, Carcaillon L, Nicholson C, Scuteri A, Sinclair A, Pelaez M, Van der Cammen T, Beland F, Bickenbach J, Delamarche P, Ferrucci L, Fried LP, Gutiérrez-Robledo LM, Rockwood K, Rodríguez Artalejo F, Serviddio G, Vega E; FOD-CC group.
The journals of gerontology. Series A, Biological sciences and medical sciences. 2013 Jan;68(1):62-7. doi: 10.1093/gerona/gls119. Epub 2012 Apr 16.. 62-67. FI: 4.984
Adrenoreceptors are involved in the stimulation of neutrophils by exercise-induced circulating concentrations of Hsp72: cAMP as a potential "intracellular danger signal".
Hinchado MD, Giraldo E, Ortega E
Journal of cellular physiology. 2012 Feb. 604-8. FI: 4.218
Anti-“negative-doping” testing: a new perspective in anti-doping research?
Lippi G, Sanchis-Gomar F, Banfi G
European journal of applied physiology. 2012 Jun. 2383-4. FI: 2.66
Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase.
Radyuk SN, Gambini J, Borras C, Serna E, Klichko VI, Viña J, Orr WC
Mechanisms of ageing and development. 2012 Jun. 401-13. FI: 3.264
Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPSWE/PS1DE9 transgenic model of alzheimer disease: effects of melatonin or ramelteon.
Otalora BB, Popovic N, Gambini J, Popovic M, Viña J, Bonet-Costa V, Reiter RJ, Camello PJ, Rol MÁ, Madrid JA
Chronobiology international. 2012 Aug. 822-34. FI: 4.35
Current limitations and future perspectives of the Athlete Blood Passport.
Lippi G, Plebani M, Sanchis-Gomar F, Banfi G
European journal of applied physiology. 2012 Oct. 3693-4. FI: 2.66
Epigenetic biomarkers: A new perspective in laboratory diagnostics.
García-Giménez JL, Sanchis-Gomar F, Lippi G, Mena S, Ivars D, Gomez-Cabrera MC, Viña J, Pallardó FV
Clinica chimica acta; international journal of clinical chemistry. 2012 Oct 9. 1576-82. FI: 2.85
Front-of-Package Nutrition Labeling and Obesity Implications.
Sanchis-Gomar F, Lippi G
American journal of preventive medicine. 2012 Jan. e1. FI: 3.945
Guided implant surgery with modification of the technique involving the raising of a semicircular miniflap: a preliminary study.
Peñarrocha M, Viña J, Maestre L, Peñarrocha D, Balaguer J
Medicina oral, patología oral y cirugía bucal. 2012 Sep 1. e775-80. FI: 1.13
Hb(mass) for anti-doping purposes should be assessed in combination with hemoglobin and blood volume.
Sanchis-Gomar F, Lippi G
International journal of sports medicine. 2012 Jun. 502. FI: 2.268
Histone carbonylation occurs in proliferating cells.
García-Giménez JL, Ledesma AM, Esmoris I, Romá-Mateo C, Sanz P, Viña J, Pallardó FV
Free radical biology & medicine. 2012 Apr 15. 1453-64. FI: 5.271
Inhibition of xanthine oxidase by allopurinol prevents skeletal muscle atrophy: role of p38 MAPKinase and E3 ubiquitin ligases.
Derbre F, Ferrando B, Gomez-Cabrera MC, Sanchis-Gomar F, Martinez-Bello VE, Olaso-Gonzalez G, Diaz A, Gratas-Delamarche A, Cerda M, Viña J
PloS one. 2012. e46668. FI: 3.73
Intermittent hypobaric hypoxia applicability in myocardial infarction prevention and recovery.
Sanchis-Gomar F, Viña J, Lippi G
Journal of cellular and molecular medicine. 2012 May. 1150-4. FI: 4.753
Irisin: a new potential hormonal target for the treatment of obesity and type 2 diabetes.
Sanchis-Gomar F, Lippi G, Mayero S, Perez-Quilis C, García-Giménez JL
Journal of diabetes. 2012 Sep. 196. FI: 2.939
Laboratory medicine and sports: between Scylla and Charybdis.
Lippi G, Banfi G, Botrè F, de la Torre X, De Vita F, Gomez-Cabrera MC, Maffulli N, Marchioro L, Pacifici R, Sanchis-Gomar F, Schena F, Plebani M
Clinical chemistry and laboratory medicine : CCLM / FESCC. 2012 Feb 28. 1309-16. FI: 3.009
Mitochondria as sources and targets of damage in cellular aging.
Gomez-Cabrera MC, Sanchis-Gomar F, Garcia-Valles R, Pareja-Galeano H, Gambini J, Borras C, Viña J
Clinical chemistry and laboratory medicine : CCLM / FESCC. 2012 Feb 1. 1287-95. FI: 3.009
Physical exercise as an epigenetic modulator: eustress, the "positive stress" as an effector of gene expression.
Sanchis-Gomar F, Garcia-Gimenez JL, Perez-Quilis C, Gomez-Cabrera MC, Pallardo FV, Lippi G
Journal of strength and conditioning research / National Strength & Conditioning Association. 2012 Dec. 3469-72. FI: 1.795
Plasticizer detection in urine samples after autologous blood transfusion.
Sanchis-Gomar F, Banfi G, Lippi G
Transfusion. 2012 Mar. 680; author reply 680-1. FI: 3.526
Survival of implants placed with the osteotome technique: an update.
Viña-Almunia J, Maestre-Ferrín L, Alegre-Domingo T, Peñarrocha-Diago M
Medicina oral, patología oral y cirugía bucal. 2012 Sep 1. e765-8. FI: 1.13
Centenarians, but not octogenarians, up-regulate the expression of microRNAs.
Serna E, Gambini J, Borras C, Mohammed K, Belenguer A, Sanchis P, Avellana JA, Rodriguez-Mañas L, Viña J
Scientific reports. 2012. 961. FI: 2.927
Telmisartan as metabolic modulator: a new perspective in sports doping?
Sanchis-Gomar F, Lippi G
Journal of strength and conditioning research / National Strength & Conditioning Association. 2012 Mar. 608-10. FI: 1.795
The financial crisis implications on the expected 2012 Olympics public health effect.
Sanchis-Gomar F, Martinez-Bello VE, Pareja-Galeano H, Lippi G
Perspectives in public health. 2012 Mar. 59
The skeletal muscle-metabolism axis in prostate-cancer therapy.
Sanchis-Gomar F
The New England journal of medicine. 2012 Dec 6. 2257-8; author reply 2258. FI: 51.658
Three weeks of erythropoietin treatment hampers skeletal muscle mitochondrial biogenesis in rats.
Martinez-Bello VE, Sanchis-Gomar F, Romagnoli M, Derbre F, Gomez-Cabrera MC, Viña J
Journal of physiology and biochemistry. 2012 Dec. 593-601. FI: 1.654
Variation of serum and urinary neutrophil gelatinase associated lipocalin (NGAL) after strenuous physical exercise.
Lippi G, Sanchis-Gomar F, Salvagno GL, Aloe R, Schena F, Guidi GC
Clinical chemistry and laboratory medicine : CCLM / FESCC. 2012 Feb 14. 1585-9. FI: 3.009
Vitamin C Supplementation Does not Improve Hypoxia-Induced Erythropoiesis.
Martinez-Bello VE, Sanchis-Gomar F, Martinez-Bello D, Olaso-Gonzalez G, Gomez-Cabrera MC, Viña J
High altitude medicine & biology. 2012 Dec. 269-74. FI: 2.122
Exercise acts as a drug; the pharmacological benefits of exercise.
Vina J, Sanchis-Gomar F, Martinez-Bello V, Gomez-Cabrera M
British journal of pharmacology. 2012 Sep. 43435. FI: 5.067
Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training.
Derbré F, Gomez-Cabrera MC, Nascimento AL, Sanchis-Gomar F, Martinez-Bello VE, Tresguerres JA, Fuentes T, Gratas-Delamarche A, Monsalve M, Viña J
Age (Dordrecht, Netherlands). 2012 Jun. 669-79. FI: 4.084
Antioxidant supplements in exercise: worse than useless?.
Gomez-Cabrera MC, Ristow M, Viña J
American journal of physiology. Endocrinology and metabolism. 2012 Feb. E476-7; author reply E478-9. FI: 4.514
Effects of physical exercise on cognitive alterations and oxidative stress in an APP/PSN1 transgenic model of Alzheimer's disease.
Pareja-Galeano H, Brioche T, Sanchís-Gomar F, Escrivá C, Dromant M, Gómez-Cabrera MC, Viña J
Revista española de geriatría y gerontología. 2012 Sep. 198-204

Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevencion dietetica temprana.

Referencia:
CIN-2017-117
Investigador principal:
Consuelo Borrás Blasco
Entidad financiadora:
Ministerio de Economía, Industria y Competitividad
Duración:
01/12/2017 - 30/11/2020
Presupuesto total:
€143.000

Maternal obesity and cognitive dysfunction in the offspring: causeeffect role of the GUT MicrobiOMe and early dietary prevention.

Referencia:
INTIMIC-085
Investigador principal:
Consuelo Borrás Blasco
Entidad financiadora:
European Commission
Duración:
01/01/2017 - 01/01/2020
Presupuesto total:
€778.240

A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.

Referencia:
PIE15/00013
Investigador principal:
Vicente Bodí Peris
Entidad financiadora:
Instituto de Salud Carlos III
Duración:
01/01/2016 - 31/12/2018
Presupuesto total:
€589.050

Papel de APC-C/Cdh1 en la Enfermedad de Alzheimer: bases moleculares y búsqueda de nuevos biomarcadores.

Referencia:
AICO/16/078
Investigador principal:
Ana Lloret Alcañiz
Entidad financiadora:
Conselleria de Educación, Cultura y Deporte
Duración:
01/01/2016 - 31/12/2018
Presupuesto total:
€40.000

Estudio del papel de la enzima xantina oxidoreductasa en la pérdida de masa muscular en modelos animales y humanos. Implicaciones en el tratamiento de la sarcopenia primaria y secundaria.

Referencia:
AICO/16/076
Investigador principal:
Mª Carmen Gómez Cabrera
Entidad financiadora:
Conselleria de Educación, Cultura y Deporte
Duración:
01/01/2016 - 31/12/2018
Presupuesto total:
€37.800

Efecto de la administración de genisteína y/o bexaroteno para el tratamiento de la enfermedad de Alzheimer en el modelo de ratón transgénico APP/PS1.

Referencia:
AICO/16/067
Investigador principal:
Consuelo Borrás Blasco
Entidad financiadora:
Consellería de Cultura, Educación y Deportes, Generalitat valenciana
Duración:
01/01/2016 - 31/12/2018
Presupuesto total:
€39.900

Señalización por radicales libres de oxígeno en células madre: importancia en medicina regenerativa.

Referencia:
PROMETEOII/2014/056
Investigador principal:
José Viña Ribes
Entidad financiadora:
Generalitat Valenciana
Duración:
01/01/2015 - 31/12/2017
Presupuesto total:
€240.000

Soportes tridimensionales biodegradables basados en macropartículas para la regeneración del cartílago articular.

Referencia:
VLC-BIOCLINIC INCLIVA 5
Investigador principal:
Carmen Carda Batalla
Entidad financiadora:
Fundación Investigación Hospital Clínico Universitario de Valencia
Duración:
01/01/2015 - 31/12/2015
Presupuesto total:
€4.000

Perfiles metabolómicos para la detección temprana de la fragilidad en ancianos.

Referencia:
CS2015-APM-03
Investigador principal:
Consuelo Borrás Blasco
Entidad financiadora:
Generalitat Valenciana. Conselleria de Sanitat
Duración:
01/01/2015 - 31/12/2015
Presupuesto total:
€12.087

Diseño de una plataforma experimental basada en la microbalanza electroquímica de cristal de cuarzo (EQCM) para el desarrollo y ensayo in-vivo de nuevas aleaciones biomédicas.

Referencia:
07_EQ-BIO-2015
Investigador principal:
Carmen Carda Batalla
Entidad financiadora:
Ministerio de Educación, Cultura y Deporte
Duración:
01/01/2015 - 31/12/2015

Red Temática de Investigación Cooperativa en Fragilidad y Envejecimiento (RETICEF).

Referencia:
RD12/0043/0029
Investigador principal:
José Viña Ribes
Entidad financiadora:
Instituto de Salud Carlos III
Duración:
01/01/2013 - 01/01/2016
Presupuesto total:
€56.016

Estudio de parámetros de longevidad en mujeres con tratamiento de estrógenos y progestágenos tras una menopausia inducida con GnRH.

Referencia:
RS2012-609
Investigador principal:
Consuelo Borrás Blasco
Entidad financiadora:
Fundación Investigación Hospital Clínico Universitario de Valencia
Duración:
01/01/2013 - 31/12/2014
Presupuesto total:
€7.680

Utility of OMIC-based biomarkers in characterizing older individuals at risk of frailty, its progression to disability and general consequences to health and well-being. The FRAILOMIC Initiative.

Referencia:
FRAILOMIC-HEALTH.2012.2.1
Investigador principal:
José Viña Ribes
Entidad financiadora:
European Commission
Duración:
01/01/2013 - 30/12/1899
Presupuesto total:
€596.520

Efectos metabólicos y sobre el rendimiento de la administración de agonistas PPAR. ¿Nuevo método de dopaje genético?.

Referencia:
2011/06RM
Investigador principal:
Mª Carmen Gómez Cabrera
Entidad financiadora:
Cátedra Real Madrid-UEM
Duración:
01/01/2012 - 01/01/2013
Presupuesto total:
€6.000

Environment, genes and prevalence of diabetes mellitus in Sapin. Dia@betes study.

Referencia:
Di@bet.es
Investigador principal:
Rafael Carmena Rodríguez
Entidad financiadora:
CIBERDEM
Duración:
22/10/2012 - 22/10/2012

Frailty operative definition-consensus conference 'FOD-CC'.

Referencia:
FOD-CC-HEALTH.2010.2.2.2
Investigador principal:
José Viña Ribes
Entidad financiadora:
European Commission
Duración:
01/01/2011 - 01/01/2012
Presupuesto total:
€72.200

Modulación de los genes de longevidad y su importancia en la prevención de enfermedades asociadas al envejecimiento.

Referencia:
SAF2010-19498
Investigador principal:
José Viña Ribes
Entidad financiadora:
Ministerio de Ciencia y Tecnología
Duración:
01/01/2010 - 31/12/2012
Presupuesto total:
€120.000

Red Temática de Investigación Cooperativa en Fragilidad y Envejecimiento (RETICEF).

Referencia:
ISCIII2006-RED13-027
Investigador principal:
José Viña Ribes
Entidad financiadora:
Instituto de Salud Carlos III
Duración:
01/01/2007 - 01/01/2013
Presupuesto total:
€496.408

Identificación de biomarcadores de fragilidad y de estrategias para su prevención y tratamiento. Centenarios como un modelo de envejecimiento saludable.

Referencia:
SAF2013-44663-R
Investigador principal:
José Viña Ribes
Entidad financiadora:
Ministerio de Economía y Competitividad
Duración:
31/12/1899 - 31/12/2016
Presupuesto total:
€217.800

Papel de los radicales libres en la biología de las células madre. Importancia en el desarrollo del envejecimiento.

Referencia:
PROMETEO/2010/074
Investigador principal:
José Viña Ribes
Entidad financiadora:
Generalitat Valenciana
Duración:
31/12/1899 - 31/12/2013
Presupuesto total:
€55.090

INCLIVA, aliado de investigación para las empresas del Patronato de ADEIT

Reunión entre ADEIT e INCLIVA para buscar sinergias.

Publicado el 19/04/2018.Leer más »

INCLIVA y AINIA investigan alimentos funcionales con genisteína para la prevención del Alzheimer

La genisteína es una sustancia química de origen vegetal presente en plantas como la soja, el kudzu, el lúpulo o el trébol rojo que está siendo investigada para la prevención del Alzheimer.

Publicado el 14/02/2018.Leer más »

INCLIVA celebra el Día la Mujer y la Niña en Ciencia con charlas en colegios valencianos

Investigación sanitaria con perspectiva de género 

Publicado el 07/02/2018.Leer más »

Según un estudio de INCLIVA la clave del envejecimiento saludable podría estar en la vía de síntesis de algunos microRNAs

Las personas con longevidad extrema viven más y experimentan un envejecimiento más saludable.

Publicado el 06/11/2017.Leer más »

Un estudio con ratones demuestra que el ejercicio físico retrasa la aparición de la fragilidad

El Grupo de Investigación en envejecimiento y ejercicio físico del INCLIVA y de la Universitat de Valencia publica un estudio con ratones que demuestra que el ejercicio físico retrasa la aparición de la fragilidad.

Publicado el 27/04/2017.Leer más »

Un año más, los investigadores de INCLIVA entre los mejores investigadores de Valencia

Según el ranking basado en el factor h elaborado por DIH, el Dr. Carlos Simón el segundo en el ranking de su especialidad en España.

Publicado el 11/01/2017.Leer más »

Un equipo de INCLIVA-UV en colaboración con el CNIO encuentra nuevas evidencias a favor del papel de la oxidación en el envejecimiento

Han generado ratones transgénicos con expresión aumentada en todo su organismo de una de las enzimas más importantes en la producción de NADPH. Los animales con niveles altos de NADPH, envejecían de forma más tardía, metabolizaban mejor el azúcar y tenían una mejor coordinación en sus movimientos al envejecer. Además, las hembras transgénicas vivían un 14% más que las no transgénicas, mientras que no observaron  efectos significativos en la longevidad de los machos.

 

Publicado el 01/04/2016.Leer más »