Área Metabolismo

Neurological Decline research group

Carmina Montoliu Felix

Dr. Montoliu received her doctorate in Biological Sciences from the University of Valencia. 

She is currently developing her research activity at the Neurological Deterioration Laboratory in the INCLIVA Health Research Institute, which she combines with her work as an Associated Professor at the Pathology Department (histology area), at the same university. She has directed several different doctoral theses and master’s degrees throughout her professional career. 

She coordinates the Transversal Neurological Deterioration Program, with the participation of both clinical and basic research groups, and is a member of the joint University Clinical Hospital Research Foundation in Valencia (FIHCUV; Fundación Investigación Hospital Clínico Universitario de Valencia)-INCLIVA-University of Valencia Training and Mobility Committee. In addition, she directs the Euro-Mediterranean Master’s degree in Neuroscience and Biotechnology at the University of Valencia. 

Her research activity has produced over 95 articles published in international journals, as well as different international patents. 

Her group was the first to find a diagnostic marker for minimal hepatic encephalopathy and to identify a biomarker for detecting early cognitive impairment in patients with liver cirrhosis. 

 

•    To characterize and better understand neuropsychological changes in patients with minimal hepatic encephalopathy (MHE) both when alert and during sleep. 
•    To analyze the brain alterations responsible for neurological and psychological changes in MHE patients. 
•    Analyze the contribution of oxidative and nitrosative stress and of inflammation to the presence and grade of MHE as well as any specific neuropsychological changes in cirrhotic patients. 

To achieve these general goals, the following specific objectives are being addressed:

•    Characterization of neuropsychological deficiencies in patients with MHE: selective and sustained attention, motor coordination, quickness of perception, and spatial intelligence. 
•    Characterization of sleep disturbances in cirrhotic patients. Comparison of the sleep disturbances in patients with and without MHE. Analysis of the relationship of any alterations found to the default mode network or to attention and coordination, as well as correlation with oxidative stress and inflammation. 
•    Analysis of oxidative and nitrosative stress and inflammation. Correlation with the presence and grade of MHE and specific neuropsychological changes: attention and motor coordination, sleep and brain alterations identified by functional magnetic resonance imaging (fMRI). 
•    Study of the brain mechanisms by which MHE alters attention in these patients; fMRI studies of the pattern in different brain regions during attention testing and ‘mismatch negativity’. 
•    Study the brain connectivity of the default mode network using blood-oxygen-level dependent (BOLD) fMRI. 
•    Use fMRI to study alterations in brain mechanisms involved in the performance of complex cognitive and motor tasks in patients with MHE. 
•    Check for correlations between the abovementioned analyzed parameters. 

PATENTE

Título: Ex-vivo method for the early diagnosis of minimal hepatic encephalopathy by means of the determination of the 3-nitrotyro-
sine in serum
Inventores: C. Montoliu Felix, O. Cauli y V. Felipo Orts
Titulares: INCLIVA, Centro de Investigación Príncipe Felipe
Fecha de prioridad: 12/07/2010
Publication number: ES2372842, EP2594938, US2013/177932
Territorio y fecha de extensión: España 16/12/2013, Europa 25/01/2013, EEUU 28/03/2013