Área Cardiovascular

Electrofisiología cardiaca experimental

Francisco Javier Chorro Gascó

Licenciado en Medicina y Cirugía, Universidad de Valencia, en 1976. Doctor en Medicina y Cirugía, en 1984. Médico Especialista en Cardiología, Hospital Clínico Universitario de Valencia. Catedrático de Universidad, área de conocimiento de Medicina en la Facultad de Medicina de la Universitat de València. Coordinador de la docencia de Cardiología en la Facultad de Medicina de la Universidad de Valencia. Director del Departamento de Medicina de la Universitat de Valencia. Formación en investigación: Universidad de Valencia y Biomedisch Centrum (Universidad de Limburg, Maastricht, Holanda).

Responsable del laboratorio de electrofisiología cardíaca experimental del Servicio de Cardiología del Hospital Clínico Universitario de Valencia y coordinador del grupo de trabajo multidisciplinar integrado por: Servicio de Cardiología del Hospital Clínico Universitario de Valencia, Departamento de Fisiología de la Facultad de Medicina de Valencia, Departamento de Ingeniería Electrónica de la Universidad Politécnica de Valencia y Departamento de Ingeniería Electrónica de la Facultad de Físicas de la Universidad de Valencia.

Líneas de investigación: Electrofisiología cardiaca, cardiopatía isquémica, insuficiencia cardiaca, técnicas diagnósticas en cardiologia. Investigación multidisciplinar para el análisis de señales eléctricas cardíacas, estudio de los mecanismos de las arritmias, desarrollo de tecnología para estudios electrofisiológicos y para el tratamiento de imágenes cardiacas.

Director de 30 Tesis Doctorales. Editor de 8 libros, autor o coautor de 60 capítulos de libro y de 203 artículos en revistas indexadas, entre ellas Circulation, Journal of American College of Cardiology, European Heart Journal, Cardiovascular Research, Heart, American Heart Journal, American Journal of Cardiology, Journal of Cardiovascular Electrophysiology, Journal of Applied Physiology, American Journal of Physiology (Heart & Circulatory) o Revista Española de Cardiología.

Participación en 26 proyectos de investigación competitivos, en diez de ellos como investigador principal, y en 11 proyectos financiados por sociedades científicas. Responsable del grupo de trabajo del Servicio de Cardiología del Hospital Clínico Universitario de Valencia en la Red temática de investigación cooperativa sobre insuficiencia cardiaca “REDINSCOR” del Instituto de Salud Carlos III, y del grupo de trabajo multidisciplinar enmarcado en el proyecto PROMETEO de la Generalitat Valenciana para el estudio de los mecanismos de inicio, perpetuación y cese de los trastornos del ritmo, especialmente de los procesos fibrilatorios, con el fin de desarrollar procedimientos de análisis, técnicas diagnósticas y alternativas terapéuticas en relación con las arritmias cardiacas y la muerte súbita.

Otras actividades: Presidente de la Sociedad Valenciana de Cardiología (1995-1997). Presidente del Instituto Valenciano del Corazón  (INSVACOR) (1998-2005). Vicepresidente de la Sociedad Española de Cardiología (2007-2009). Fellow de la Sociedad Europea de Cardiología. Académico de número de la Real Academia de Medicina de Valencia.

 

Grupo de Investigación en Electrofisiología Cardiaca Experimental

Investigador colaborador

Antonio M. Alberola Aguilar
Isabel Trapero Gimeno
Joaquín Cánoves Femenía
Laura López Bueno
Luis Mainar Latorre
Luis Such Belenguer
Luis Such Miquel
Manuel Zarzoso Muñoz

Investigador predoctoral

Carlos Soler López
Irene del Canto
Laia Brines Ferrando
Óscar Julián Arias Mutis
  • Identificación de agentes farmacológicos que bloqueen o contrarresten los efectos proarritmógenos del estiramiento miocárdico.
  • Estudio de la facilitación de la captura miocárdica durante los procesos fibrilatorios mediante sobreestimulación eléctrica.  
  • Caracterización de los efectos protectores del ejercicio físico en relación con la inducción, mantenimiento y cese de las arritmias ventriculares y análisis de la influencia del sistema nervioso autónomo.
  • Estudio experimental de los efectos proarrítmicos y antiarrítmicos de las variaciones térmicas localizadas en el miocardio ventricular.
  • Análisis del papel jugado por las corrientes IKATP y por sus modificaciones en la hetergoneidad electrofisiológica durante la isquemia miocárdica. Estudio experimental.
  • Desarrollo, actualización e integración de instrumental nuevo y complementario para mejorar y ampliar los estudios de electrofisiología cardiaca experimental. Incorporación de las técnicas de cartografía óptica.
  • Analizar experimentalmente la relación entre las características de la lesión isquémica
Número total de publicaciones: 110. Factor de Impacto acumulado: 525.26
A quantitative structural and morphometric analysis of the Purkinje network and the Purkinje-myocardial junctions in pig hearts.
Garcia-Bustos V, Sebastian R, Izquierdo M, Molina P, Chorro FJ, Ruiz-Sauri A.
Journal of anatomy. 2017 Mar 3. . FI: 2.182
Balance Training With a Dynamometric Platform Following Total Knee Replacement: A Randomized Controlled Trial
Roig-Casasús S, María Blasco J, López-Bueno L, Blasco-Igual MC.
Journal of geriatric physical therapy. 2017 Mar 1. 1539-8412. FI: 1.51
Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models.
Lee P, Calvo CJ, Alfonso-Almazán JM, Quintanilla JG, Chorro FJ, Yan P, Loew LM, Filgueiras-Rama D, Millet J.
Scientific reports. 2017 Feb 27. 43217. FI: 4.259
Development and characterization of an experimental model of diet-induced metabolic syndrome in rabbit.
Arias-Mutis OJ, Marrachelli VG, Ruiz-Saurí A, Alberola A, Morales JM, Such-Miquel L, Monleon D, Chorro FJ, Such L, Zarzoso M.
PloS one. 2017. e0178315. FI: 2.806
Time-to-Effect-Based Dosing Strategy for Cryoballoon Ablation in Patients With Paroxysmal Atrial Fibrillation: Results of the plusONE Multicenter Randomized Controlled Noninferiority Trial
Ferrero-de-Loma-Osorio Á, García-Fernández A, Castillo-Castillo J, Izquierdo-de-Francisco M, Ibáñez-Críado A, Moreno-Arribas J, Martínez A, Bertomeu-González V, López-Mases P, Ajo-Ferrer M, Núñez C, Bondanza-Saavedra L, Sánchez-Gómez JM, Martínez-Martínez JG, Chorro-Gascó FJ, Ruiz-Granell R.
Circulation. Arrhythmia and electrophysiology. 2017 Dec. . FI: 5.41
Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation
Cannon CP, Bhatt DL, Oldgren J, Lip GYH, Ellis SG, Kimura T, Maeng M, Merkely B, Zeymer U, Gropper S, Nordaby M, Kleine E, Harper R, Manassie J, Januzzi JL, Ten Berg JM, Steg PG, Hohnloser SH; RE-DUAL PCI Steering Committee and Investigators.
The New England journal of medicine. 2017 Oct 19. 0028-4793. FI: 72.40600000000001
Echocardiographic pulmonary artery pressure estimation and heart failure rehospitalization burden in patients with acute heart failure
Santas E, de la Espriella-Juan R, Mollar A, Valero E, Miñana G, Sanchis J, Chorro FJ, Núñez J
International journal of cardiology. 2017 Aug. 407-410. FI: 6.189
Dynamics and implications of circulating anti-angiogenic VEGF-A165b isoform in patients with ST-elevation myocardial infarction.
Hueso L, Rios-Navarro C, Ruiz-Sauri A, Chorro FJ, Nunez J, Sanz MJ, Bodi V, Piqueras L
Scientific reports.. 2017 Aug 30. 9962. FI: 4.259
Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design.
García-Blas S, Bonanad C, Llàcer P, Ventura S, Núñez JM, Sánchez R, Chamorro C, Fácila L, de la Espriella R, Vaquer JM, Cordero A, Roqué M, Ortiz V, Racugno P, Bodí V, Valero E, Santas E, Moreno MD, Miñana G, Carratalá A, Bondanza L, Payá A, Cardells I, Heredia R, Pellicer M, Valls G, Palau P, Bosch MJ, Raso R, Sánchez A, Bertomeu-González V, Bertomeu-Martínez V, Montagud-Balaguer V, Albiach-Montañana C, Pendás-Meneau J, Marcaida G, Cervantes-García S, San Antonio R, de Mingo E, Chorro FJ, Sanchis J, Núñez J, IMPROVE-HF Investigators.
Revista española de cardiología. 2017 Mar 21. . FI: 4.485
Burden of recurrent hospitalizations following an admission for acute heart failure: preserved versus reduced ejection fraction.
Santas E, Valero E, Mollar A, García-Blas S, Palau P, Miñana G, Núñez E, Sanchis J, Chorro FJ, Núñez J
Revista española de cardiología. 2017 Apr. 239-246. FI: 4.485
Coronary Serum Obtained After Myocardial Infarction Induces Angiogenesis and Microvascular Obstruction Repair. Role of Hypoxia-inducible Factor-1A.
Ríos-Navarro C, Hueso L, Miñana G, Núñez J, Ruiz-Saurí A, Sanz MJ, Cànoves J, Chorro FJ, Piqueras L, Bodí V
Revista española de cardiología. 2017 Jul 24. . FI: 4.485
Long-Term Potassium Monitoring and Dynamics in Heart Failure and Risk of Mortality
Núñez J, Bayés-Genís A, Zannad F, Rossignol P, Núñez E, Bodí V, Miñana G, Santas E, Chorro FJ, Mollar A, Carratalá A, Navarro J, Gorriz JL, Lupón J, Husser O, Metra M, Sanchis J
Circulation. 2015 Aug. . FI: 19.309
Length of stay and risk of very early readmission in acute heart failure
Miñana G, Bosch MJ, Núñez E, Mollar A, Santas E, Valero E, García-Blas S, Pellicer M, Bodí V, Chorro FJ, Sanchis J, Núñez J
European journal of internal medicine. 2017 Jul. 61-66. FI: 2.96
Inspiratory Muscle Function and Exercise Capacity in Patients with Heart Failure with Preserved Ejection Fraction.
Palau P, Domínguez E, Núñez E, Ramón JM, López L, Melero J, Bellver A, Chorro FJ, Bodí V, Bayés-Genis A, Sanchis J, Núñez J
Journal of cardiac failure.. 2017 Apr 24. . FI: 3.259
Functional Mitral Regurgitation Predicts Short-Term Adverse Events in Patients With Acute Heart Failure and Reduced Left Ventricular Ejection Fraction.
De la Espriella R, Santas E, Miñana G, Bodí V, Valero E, Payá R, Núñez E, Payá A, Chorro FJ, Bayés-Genis A, Sanchis J, Núñez J
The American journal of cardiology.. 2017 Jul 25. . FI: 3.234
Incidence, Outcomes, and Predictors of Ventricular Thrombus after Reperfused ST-Segment-Elevation Myocardial Infarction by Using Sequential Cardiac MR Imaging.
Cambronero-Cortinas E, Bonanad C, Monmeneu JV, Lopez-Lereu MP, Gavara J, de Dios E, Rios C, Perez N, Racugno P, Paya A, Escribano D, Minana G, Pellicer M, Cànoves J, Nunez J, Chorro FJ, Moratal D, Bodi V
Radiology. RSNA index to imaging literature : an index of 34 journals [in] diagnostic radiology, nuclear medicine, ultrasound, magnetic resonance imaging and radiation therapy. 2017 Mar 2. 161898. FI: 6.798
Peak Exercise Oxygen Uptake Predicts Recurrent Admissions in Heart Failure With Preserved Ejection Fraction.
Palau P, Domínguez E, Núñez E, Ramón JM, López L, Melero J, Sanchis J, Bellver A, Santas E, Bayes-Genis A, Chorro FJ, Núñez J
Revista española de cardiología. 2017 Jun 27. . FI: 4.485
Carbohydrate antigen-125-guided therapy in acute heart failure: chance-hf: a randomized study.
Núñez J, Llàcer P, Bertomeu-González V, Bosch MJ, Merlos P, García-Blas S, Montagud V, Bodí V, Bertomeu-Martínez V, Pedrosa V, Mendizábal A, Cordero A, Gallego J, Palau P, Miñana G, Santas E, Morell S, Llàcer A, Chorro FJ, Sanchis J, Fácila L, CHANCE-HF Investigators.
JACC. Heart failure.. 2016 Nov. 833-843. FI: 8.493
Complex left main coronary stent restenosis treated through radial approach using a sheathless catheter.
García-Blas S, Mainar L, Sanchis J, Núñez J
Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.. 2016 Oct. 543.e1-5. FI: 0.873
Bioelectrical impedance vector analysis and clinical outcomes in patients with acute heart failure
Núñez J, Mascarell B, Stubbe H, Ventura S, Bonanad C, Bodí V, Núñez E, Miñana G, Fácila L, Bayés-Genis A, Chorro FJ, Sanchis J
Journal of cardiovascular medicine. 2016 Apr. 283-90. FI: 1.658
Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial.
Palau P, Domínguez E, López L, Heredia R, González J, Ramón JM, Serra P, Santas E, Bodi V, Sanchis J, Chorro FJ, Núñez J
Clinical cardiology.. 2016 Aug. 433-9. FI: 2.431
High-sensitivity troponin T and the risk of recurrent readmissions after hospitalisation for acute heart failure.
Escribano D, Santas E, Miñana G, Mollar A, García-Blas S, Valero E, Payá A, Chorro FJ, Sanchis J, Núñez J
Revista clínica española.. 2016 Nov 30. . FI: 0.971
The influence of regular physical activity on lung function in paraplegic people.
Montesinos-Magraner L, López-Bueno L, Gómez-Garrido A, Gomis M, González LM, García-Massó X, Serra-Añó P
Spinal cord.. 2016 Mar 1. . FI: 1.804
A multidisciplinary assessment of remote myocardial fibrosis after reperfused myocardial infarction in swine and patients.
Hervas A, Ruiz-Sauri A, Gavara J, Monmeneu JV, de Dios E, Rios-Navarro C, Perez-Sole N, Perez I, Monleon D, Morales JM, Minana G, Nunez J, Bonanad C, Diaz A, Vila JM, Chorro FJ, Bodi V
Journal of cardiovascular translational research.. 2016 Aug. 321-33. FI: 3.017
Usefulness of delta troponin for diagnosis and prognosis assessment of non-ST-segment elevation acute chest pain.
Sanchis J, Abellán L, García-Blas S, Mainar L, Mollar A, Valero E, Consuegra-Sánchez L, Roqué M, Bertomeu-González V, Chorro FJ, Núñez E, Núñez J
European heart journal. Acute cardiovascular care.. 2016 Sep. 399-406
Usefulness of cardiac resynchronisation therapy devices and implantable cardioverter defibrillators in the treatment of heart failure due to severe systolic dysfunction: systematic review of clinical trials and network meta-analysis.
García García MA, Rosero Arenas MA, Ruiz Granell R, Chorro Gascó FJ, Martínez Cornejo A
Heart Asia. 2016. 42217
Aborted sudden death in a cocaine consumer.
Valero E, Bondanza L, Mainar L
Revista clínica española.. 2016 May. 231-232. FI: 1.063
Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress than Ventricular Myocytes from Mice with Catecholaminergic Polymorphic Ventricular Tachycardia.
Willis BC, Pandit S, Ponce-Balbuena D, Zarzoso M, Guerrero-Serna G, Limbu B, Deo M, Cammors E, Ramirez RJ, Mironov S, Herron TJ, Valdivia HH, Jalife J
Circulation.. 2016 May 11. . FI: 15.073
Effects of JTV-519 on stretch-induced manifestations of mechanoelectric feedback.
Del Canto I, Such-Miquel L, Brines L, Soler C, Zarzoso M, Calvo C, Parra G, Tormos Á, Alberola A, Millet J, Such L, Chorro FJ
Clinical and experimental pharmacology & physiology.. 2016 Aug 8. . FI: 2.16
Extracellular Matrix-Mediated Maturation of Human Pluripotent Stem Cell-Derived Cardiac Monolayer Structure and Electrophysiological Function.
Herron TJ, Rocha AM, Campbell KF, Ponce-Balbuena D, Willis BC, Guerrero-Serna G, Liu Q, Klos M, Musa H, Zarzoso M, Bizy A, Furness J, Anumonwo J, Mironov S, Jalife J
Circulation. Arrhythmia and electrophysiology.. 2016 Apr. . FI: 4.678
Inhomogeneity of collagen organization within the fibrotic scar after myocardial infarction: results in a swine model and in human samples.
Hervas A, Ruiz-Sauri A, de Dios E, Forteza MJ, Minana G, Nunez J, Gomez C, Bonanad C, Perez-Sole N, Gavara J, Chorro FJ, Bodi V
Journal of anatomy.. 2016 Jan. 47-58. FI: 2.097
Iron deficiency and functional capacity in patients with advanced heart failure with preserved ejection fraction.
Núñez J, Domínguez E, Ramón JM, Núñez E, Sanchis J, Santas E, Heredia R, González J, Miñana G, López L, Chorro FJ, Palau P
International journal of cardiology.. 2016 Mar 15. 365-7. FI: 6.189
Iron deficiency and risk of early readmission following a hospitalization for acute heart failure.
Núñez J, Comín-Colet J, Miñana G, Núñez E, Santas E, Mollar A, Valero E, García-Blas S, Cardells I, Bodí V, Chorro FJ, Sanchis J
ESC heart failure.. 2016 Mar 30. . FI: 6.526
Prediction of long-term major events soon after a first ST-segment elevation myocardial infarction by cardiovascular magnetic resonance.
Bonanad C, Monmeneu JV, Lopez-Lereu MP, Hervas A, de Dios E, Gavara J, Nunez J, Minana G, Husser O, Paya A, Racugno P, García-Blas S, Chorro FJ, Bodi V
European journal of radiology open.. 2016 Mar. 585-92. FI: 2.369
Prediction of Reverse Remodeling at Cardiac MR Imaging Soon after First ST-Segment-Elevation Myocardial Infarction: Results of a Large Prospective Registry.
Bodi V, Monmeneu JV, Ortiz-Perez JT, Lopez-Lereu MP, Bonanad C, Husser O, Minana G, Gomez C, Nunez J, Forteza MJ, Hervas A, de Dios E, Moratal D, Bosch X, Chorro FJ
Radiology. RSNA index to imaging literature: an index of 34 journals [in] diagnostic radiology, nuclear medicine, ultrasound, magnetic resonance imaging and radiation therapy. 2016 Jan. 54-63. FI: 6.867
Endo-epicardial versus only-endocardial ablation as a first line strategy for the treatment of ventricular tachycardia in patients with ischemic heart disease
Izquierdo M, Sánchez-Gómez JM, Ferrero de Loma-Osorio A, Martínez A, Bellver A, Peláez A, Núñez J, Núñez C, Chorro J, Ruiz-Granell R
Circulation. Arrhythmia and electrophysiology. 2015 Aug. 882-9. FI: 5.41
Prognostic implications of tissue Doppler imaging-derived e/ea ratio in acute heart failure patients
Santas E, García-Blas S, Miñana G, Sanchis J, Bodí V, Escribano D, Muñoz J, Chorro FJ, Núñez J
Echocardiography. 2015 Feb. 213-20. FI: 1.314
Procalcitonin and long-term prognosis after an admission for acute heart failure
Villanueva MP, Mollar A, Palau P, Carratalá A, Núñez E, Santas E, Bodí V, Chorro FJ, Miñana G, Blasco ML, Sanchis J, Núñez J
European journal of internal medicine. 2015 Jan. 42-8. FI: 2.96
A suspicious calcium spike.
García-Blas S, Núñez J, Mainar L, Muñoz J, Martín I, Domenech A, Guillen A, Larman M, Sanchis J
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2015 Aug 22. e1. FI: 3.769
Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure.
Packer M, McMurray JJ, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile M, Andersen K, Arango JL, Arnold JM, B?lohlávek J, Böhm M, Boytsov S, Burgess LJ, Cabrera W, Calvo C, Chen CH, Dukat A, Duarte YC, Erglis A, Fu M, Gomez E, Gonzàlez-Medina A, Hagège AA, Huang J, Katova T, Kiatchoosakun S, Kim KS, Kozan Ö, Llamas EB, Martinez F, Merkely B, Mendoza I, Mosterd A, Negrusz-Kawecka M, Peuhkurinen K, Ramires FJ, Refsgaard J, Rosenthal A, Senni M, Sibulo AS Jr, Silva-Cardoso J, Squire IB, Starling RC, Teerlink JR, Vanhaecke J, Vinereanu D, Wong RC, PARADIGM-HF Investigators and Coordinators
Circulation. 2015 Jan 6. 54-61. FI: 14.43
Characterization of normal regional myocardial function by MRI cardiac tagging
Del-Canto I, López-Lereu MP, Monmeneu JV, Croisille P, Clarysse P, Chorro FJ, Bodí V, Moratal D
Journal of magnetic resonance imaging : JMRI. 2015 Jan. 83-92. FI: 3.21
Determining cut-off points in functional assessment scales in stroke.
Balasch I Bernat M, Balasch I Parisi S, Sebastián EN, Moscardó LD, Ferri Campos J, López Bueno L
NeuroRehabilitation.. 2015 Oct 14. 165-72. FI: 1.124
Experimental Study of the Effects of EIPA, Losartan, and BQ-123 on Electrophysiological Changes Induced by Myocardial Stretch.
Chorro FJ, Canto ID, Brines L, Such-Miquel L, Calvo C, Soler C, Zarzoso M, Trapero I, Tormos Á, Such L
Revista española de cardiología. 2015 Dec. 1101-10
Heart rate variability in individuals with thoracic spinal cord injury.
Serra-Añó P, Montesinos LL, Morales J, López-Bueno L, Gomis M, García-Massó X, González LM
Spinal cord. 2015 Jan. 59-63. FI: 1.804
Intracoronary Infusion of Thioflavin-S to Study Microvascular Obstruction in a Model of Myocardial Infarction.
Hervas A, de Dios E, Forteza MJ, Miñana G, Nuñez J, Ruiz-Sauri A, Bonanad C, Perez-Sole N, Chorro FJ, Bodi V
Revista española de cardiología. 2015 Nov. 928-34. FI: 4.596
POSTURAL CONTROL MECHANISMS IN HEALTHY ADULTS IN SITTING AND STANDING POSITIONS.
Serra-Añó P, López-Bueno L, García-Massó X, Pellicer-Chenoll MT, González LM
Perceptual and motor skills.. 2015 Aug. 119-34. FI: 0.546
Prevalence of Stable Angina in Spain. Results of the OFRECE Study.
Alonso JJ, Muñiz J, Gómez-Doblas JJ, Rodríguez-Roca G, Lobos JM, Permanyer-Miralda G, Anguita M, Chorro FJ, Roig E, OFRECE study researchers
Revista española de cardiología. 2015 Aug. 691-9
Prognostic implications of pericardial effusion in acute heart failure: Does size matter?
Santas E, Sandino J, Chorro FJ, Méndez J, Miñana G, Núñez E, Sanchis J, Núñez J
International journal of cardiology.. 2015 Apr 1. 259-61. FI: 4.036
Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure.
Núñez J, Rabinovich GA, Sandino J, Mainar L, Palau P, Santas E, Villanueva MP, Núñez E, Bodí V, Chorro FJ, Miñana G, Sanchis J
PLoS hub for clinical trials. 2015. e0122360. FI: 3.234
Ranolazine Attenuates the Electrophysiological Effects of Myocardial Stretch in Langendorff-Perfused Rabbit Hearts.
Chorro FJ, del Canto I, Brines L, Such-Miquel L, Calvo C, Soler C, Parra G, Zarzoso M, Trapero I, Tormos Á, Alberola A, Such L
Cardiovascular drugs and therapy. 2015 Jun. 231-41. FI: 3.189
Right atrial mass.
Valero E, Santas E, Chorro FJ
Revista clínica española.. 2015 Aug-Sep. 357-8. FI: 1.063
Spectral analysis-based risk score enables early prediction of mortality and cerebral performance in patients undergoing therapeutic hypothermia for ventricular fibrillation and comatose status.
Filgueiras-Rama D, Calvo CJ, Salvador-Montañés Ó, Cádenas R, Ruiz-Cantador J, Armada E, Rey JR, Merino JL, Peinado R, Pérez-Castellano N, Pérez-Villacastín J, Quintanilla JG, Jiménez S, Castells F, Chorro FJ, López-Sendón JL, Berenfeld O, Jalife J, de Sá EL, Millet J
International journal of cardiology. 2015 Mar 14. 250-258. FI: 4.036
Study of the Recovery Patterns of Elderly Subacute Stroke Patients in an Interdisciplinary Neurorehabilitation Unit.
Balasch I Bernat M, Balasch I Parisi S, Noé Sebastián E, Dueñas Moscardó L, Ferri Campos J, Lopez-Bueno L
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2015 Oct. 2213-8. FI: 1.669
Symptomatic Partial Congenital Absence of the Pericardium Revealed Using Cardiac Magnetic Resonance.
Valero E, Ferrero JA, López-Lereu MP, Chorro FJ
The Canadian journal of cardiology.. 2015 Oct. 1303.e5-7. FI: 3.711
Tricuspid Regurgitation and Mortality Risk Across Left Ventricular Systolic Function in Acute Heart Failure.
Santas E, Chorro FJ, Miñana G, Méndez J, Muñoz J, Escribano D, García-Blas S, Valero E, Bodí V, Núñez E, Sanchis J, Núñez J
Circulation journal : official journal of the Japanese Circulation Society. 2015. 1526-33. FI: 3.94
Use of Anticoagulants and Antiplatelet Agents in Stable Outpatients with Coronary Artery Disease and Atrial Fibrillation. International CLARIFY Registry.
Fauchier L, Greenlaw N, Ferrari R, Ford I, Fox KM, Tardif JC, Tendera M, Steg PG, CLARIFY Investigators
PloS one. 2015. e0125164. FI: 3.234
Usefulness and safety of a guide catheter extension system for the percutaneous treatment of complex coronary lesions by a transradial approach.
García-Blas S, Núñez J, Mainar L, Miñana G, Bonanad C, Racugno P, Rodríguez JC, Moyano P, Sanchis J
Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2015. 171-7. FI: 1.34
Usefulness of Clinical Data and Biomarkers for the Identification of Frailty After Acute Coronary Syndromes.
Sanchis J, Núñez E, Ruiz V, Bonanad C, Fernández J, Cauli O, García-Blas S, Mainar L, Valero E, Rodríguez-Borja E, Chorro FJ, Hermenegildo C, Núñez J
The Canadian journal of cardiology.. 2015 Dec. 1462-8. FI: 3.711
Angiotensin-neprilysin inhibition versus enalapril in heart failure.
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, PARADIGM-HF Investigators and Committees
The New England journal of medicine. 2014 Sep 11. 993-1004. FI: 54.42
Application of machine learning techniques to analyse the effects of physical exercise in ventricular fibrillation.
Caravaca J, Soria-Olivas E, Bataller M, Serrano AJ, Such-Miquel L, Vila-Francés J, Guerrero JF
Computers in biology and medicine. 2014 Feb. 42186. FI: 1.475
Antigen carbohydrate 125 and creatinine on admission for prediction of renal function response following loop diuretic administration in acute heart failure.
Núñez J, Llàcer P, Núñez E, Ventura S, Bonanad C, Bodí V, Miñana G, Santas E, Mascarell B, Fonarow GC, Chorro FJ, Sanchis J
International journal of cardiology. 2014 Jul 1. 516-23. FI: 6.175
Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation.
Martins RP, Kaur K, Hwang E, Ramirez RJ, Willis BC, Filgueiras-Rama D, Ennis SR, Takemoto Y, Ponce-Balbuena D, Zarzoso M, O'Connell RP, Musa H, Guerrero-Serna G, Avula UM, Swartz MF, Bhushal S, Deo M, Pandit SV, Berenfeld O, Jalife J
Circulation. 2014 Apr 8. 1472-82. FI: 14.948
Dynamics of serum-induced endothelial cell apoptosis in patients with myocardial infarction.
Forteza MJ, Novella S, Trapero I, Hermenegildo C, Ruiz-Sauri A, Chaustre F, Bonanad C, Oltra R, Palacios L, O Connor JE, Chorro FJ, Bodi V
European journal of clinical investigation. 2014 Jan. 46-53. FI: 2.834
Clinical utility of antigen carbohydrate 125 in heart failure.
Núñez J, Miñana G, Núñez E, Chorro FJ, Bodí V, Sanchis J
Heart failure reviews. 2014 Sep. 575-84. FI: 3.991
Early serum creatinine changes and outcomes in patients admitted for acute heart failure: the cardio-renal syndrome revisited.
Núñez J, Garcia S, Núñez E, Bonanad C, Bodí V, Miñana G, Santas E, Escribano D, Bayes-Genis A, Pascual-Figal D, Chorro FJ, Sanchis J
European heart journal. Acute cardiovascular care. 2014 Jul 30.
Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine.
Bodi V, Ruiz-Nodar JM, Feliu E, Minana G, Nunez J, Husser O, Martinez-Elvira J, Ruiz A, Bonanad C, Monmeneu JV, Lopez-Lereu MP, Forteza MJ, de Dios E, Hervas A, Moratal D, Gomez C, Mainar L, Sanchis J, Mainar V, Valencia J, Diaz A, Noguera I, Chaustre F, Chorro FJ
International journal of cardiology. 2014 Jul 15. 138-46. FI: 6.175
Effects of inspiratory muscle training in patients with heart failure with preserved ejection fraction.
Palau P, Domínguez E, Núñez E, Schmid JP, Vergara P, Ramón JM, Mascarell B, Sanchis J, Chorro FJ, Núñez J
European journal of preventive cardiology. 2014 Dec. 1465-73. FI: 2.675
Experience in daily clinical practice of ambulatory cardioversion of atrial fibrillation treated with new oral anticoagulants.
Santas E, Méndez J, Martínez-Brotons A, Núñez J, Chorro FJ, Ruiz-Granell R
Revista española de cardiología (English ed.). 2014 Nov. 960-1
Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome.
Sanchis J, Bonanad C, Ruiz V, Fernández J, García-Blas S, Mainar L, Ventura S, Rodríguez-Borja E, Chorro FJ, Hermenegildo C, Bertomeu-González V, Núñez E, Núñez J
American heart journal. 2014 Nov. 784-791.e2. FI: 4.555
High-sensitivity versus conventional troponin for management and prognosis assessment of patients with acute chest pain.
Sanchis J, García-Blas S, Mainar L, Mollar A, Abellán L, Ventura S, Bonanad C, Consuegra-Sánchez L, Roqué M, Chorro FJ, Núñez E, Núñez J
Heart (British Cardiac Society). 2014 Oct. 1591-6. FI: 6.023
Impact of chronic kidney disease on use of evidence-based therapy in stable coronary artery disease: a prospective analysis of 22,272 patients.
Kalra PR, García-Moll X, Zamorano J, Kalra PA, Fox KM, Ford I, Ferrari R, Tardif JC, Tendera M, Greenlaw N, Steg PG, CLARIFY Investigators
PloS one. 2014. e102335. FI: 3.534
Outcome of patients with local complications at the site of an implantable device.
Izquierdo M, Bonanad C, Madrazo I, Ferrero A, Martínez A, Morell S, Chorro J, Ruiz-Granell R
Archivos de cardiología de México. 2014 Jan-Mar. 42251
Interleukin 6 and cognitive dysfunction.
Trapero I, Cauli O
Metabolic brain disease. 2014 Sep. 593-608. FI: 2.398
Prevalence of Atrial Fibrillation in Spain. OFRECE Study Results.
Gómez-Doblas JJ, Muñiz J, Martin JJ, Rodríguez-Roca G, Lobos JM, Awamleh P, Permanyer-Miralda G, Chorro FJ, Anguita M, Roig E, en representación de los colaboradores del estudio OFRECE
Revista española de cardiología. 2014 Apr. 259-269. FI: 3.342
Prevalence of atrial fibrillation in Spain. OFRECE study results.
Gómez-Doblas JJ, Muñiz J, Martin JJ, Rodríguez-Roca G, Lobos JM, Awamleh P, Permanyer-Miralda G, Chorro FJ, Anguita M, Roig E, OFRECE study collaborators
Revista española de cardiología (English ed.). 2014 Apr. 259-69
Prognostic value of the electrocardiogram in patients with syncope: data from the group for syncope study in the emergency room (GESINUR).
Pérez-Rodon J, Martínez-Alday J, Barón-Esquivias G, Martín A, García-Civera R, Del Arco C, Cano-Gonzalez A, Moya-Mitjans A
Heart rhythm : the official journal of the Heart Rhythm Society. 2014 Nov. 2035-44. FI: 4.918
Programmed death-1 (PD-1): a novel mechanism for understanding the acute immune deregulation in ST-segment elevation myocardial infarction.
Forteza MJ, Hervas A, de Dios E, Trapero I, Ruiz-Sauri A, Minana G, Bonanad C, Gomez C, Husser O, Nunez J, Chorro FJ, Bodi V
International journal of cardiology. 2014 Nov 15. 42285. FI: 6.175
QT Interval Heterogeneities Induced Through Local Epicardial Warming/Cooling. An Experimental Study.
Guill A, Tormos A, Millet J, Roses EJ, Cebrián A, Such-Miquel L, Such L, Zarzoso M, Alberola A, Chorro FJ
Revista española de cardiología. 2014 Aug 4. . FI: 3.342
Prognostic value of myocardial ischemia and necrosis in depressed left ventricular function: a multicenter stress cardiac magnetic resonance registry.
Husser O, Monmeneu JV, Bonanad C, Lopez-Lereu MP, Nuñez J, Bosch MJ, Garcia C, Sanchis J, Chorro FJ, Bodi V
Revista española de cardiología (English ed.). 2014 Sep. 693-700
QT interval heterogeneities induced through local epicardial warming/cooling. An experimental study.
Guill A, Tormos A, Millet J, Roses EJ, Cebrián A, Such-Miquel L, Such L, Zarzoso M, Alberola A, Chorro FJ
Revista española de cardiología. 2014 Dec. 993-8
Red blood cell distribution width is longitudinally associated with mortality and anemia in heart failure patients.
Núñez J, Núñez E, Rizopoulos D, Miñana G, Bodí V, Bondanza L, Husser O, Merlos P, Santas E, Pascual-Figal D, Chorro FJ, Sanchis J
Circulation journal : official journal of the Japanese Circulation Society. 2014 Jan 24. 410-8. FI: 3.685
Reduced Na? current density underlies impaired propagation in the diabetic rabbit ventricle.
Stables CL, Musa H, Mitra A, Bhushal S, Deo M, Guerrero-Serna G, Mironov S, Zarzoso M, Vikstrom KL, Cawthorn W, Pandit SV
Journal of molecular and cellular cardiology. 2014 Apr. 24-31. FI: 5.218
Subsequent Full Publication of Abstracts Presented in the Annual Meetings of the Spanish Society of Cardiology.
Alonso-Arroyo A, Aleixandre-Benavent R, Vidal-Infer A, Anguita-Sánchez M, Chorro-Gascó FJ, Bolaños-Pizarro M, Castelló-Cogollos L, Navarro-Molina C, Valderrama-Zurián JC, en colaboración con el Comité Ejecutivo de la Sociedad Española de Cardiología
Revista española de cardiología. 2014 Jan. 15-21. FI: 3.342
Ventricular remodelling in rabbits with sustained high-fat diet.
Zarzoso M, Mironov S, Guerrero-Serna G, Willis BC, Pandit SV
Acta physiologica (Oxford, England). 2014 May. 36-47. FI: 4.251
Emergency and prophylactic use of miniaturized veno-arterial extracorporeal membrane oxygenation in transcatheter aortic valve implantation.
Husser O, Holzamer A, Philipp A, Nunez J, Bodi V, Müller T, Lubnow M, Luchner A, Lunz D, Riegger GA, Schmid C, Hengstenberg C, Hilker M
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2013 Oct 1. E542-51. FI: 2.396
Long-term Prognostic Value of a Comprehensive Assessment of Cardiac Magnetic Resonance Indexes After an ST-segment Elevation Myocardial Infarction.
Merlos P, López-Lereu MP, Monmeneu JV, Sanchis J, Núñez J, Bonanad C, Valero E, Miñana G, Chaustre F, Gómez C, Oltra R, Palacios L, Bosch MJ, Navarro V, Llácer A, Chorro FJ, Bodí V
Revista española de cardiología. 2013 Aug. 613-22. FI: 3.204
Low-fat dairy products consumption is associated with lower triglyceride concentrations in a Spanish hypertriglyceridemic cohort.
Merino J, Mateo-Gallego R, Plana N, Bea AM, Ascaso J, Lahoz C, Aranda JL, Hypertriglyceridemic Registry of Spanish Arteriosclerosis Society
Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral. 2013 May-Jun. 927-33. FI: 1.305
Metabolomics in the diagnosis of acute myocardial ischemia.
Bodi V, Marrachelli VG, Husser O, Chorro FJ, Viña JR, Monleon D
Journal of cardiovascular translational research. 2013 Oct. 808-15. FI: 3.062
Microvascular obstruction in the right ventricle in reperfused anterior myocardial infarction. Macroscopic and pathologic evidence in a swine model.
Bonanad C, Ruiz-Sauri A, Forteza MJ, Chaustre F, Minana G, Gomez C, Diaz A, Noguera I, de Dios E, Nunez J, Mainar L, Sanchis J, Morales JM, Monleon D, Chorro FJ, Bodi V
Thrombosis research. 2013 Nov. 592-8. FI: 3.133
Predictors of cardiovascular magnetic resonance-derived microvascular obstruction on patient admission in STEMI.
Husser O, Bodi V, Sanchis J, Nunez J, Lopez-Lereu MP, Monmeneu JV, Gomez C, Rumiz E, Merlos P, Bonanad C, Minana G, Valero E, Chaustre F, Forteza MJ, Riegger GA, Chorro FJ, Llacer A
International journal of cardiology. 2013 Jun 5. 77-84. FI: 6.175
Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes.
Bizy A, Guerrero-Serna G, Hu B, Ponce-Balbuena D, Willis BC, Zarzoso M, Ramirez RJ, Sener MF, Mundada LV, Klos M, Devaney EJ, Vikstrom KL, Herron TJ, Jalife J
Stem cell research. 2013 Nov. 1335-47. FI: 4.467
The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial.
Mitjavila MT, Fandos M, Salas-Salvadó J, Covas MI, Borrego S, Estruch R, Lamuela-Raventós R, Corella D, Martínez-Gonzalez MÁ, Sánchez JM, Bulló M, Fitó M, Tormos C, Cerdá C, Casillas R, Moreno JJ, Iradi A, Zaragoza C, Chaves J, Sáez GT
Clinical nutrition (Edinburgh, Scotland). 2013 Apr. 172-8. FI: 3.298
Ventricular fibrillation conduction through an isthmus of preserved myocardium between radiofrequency lesions.
Chorro FJ, Ibañez-Catalá X, Trapero I, Such-Miquel L, Pelechano F, Cánoves J, Mainar L, Tormos A, Cerdá JM, Alberola A, Such L
Pacing and clinical electrophysiology : PACE. 2013 Mar. 286-98. FI: 1.746
Value of Early Cardiovascular Magnetic Resonance for the Prediction of Adverse Arrhythmic Cardiac Events After a First Noncomplicated ST-Segment-Elevation Myocardial Infarction.
Izquierdo M, Ruiz-Granell R, Bonanad C, Chaustre F, Gomez C, Ferrero A, Lopez-Lereu P, Monmeneu JV, Nuñez J, Chorro FJ, Bodi V
Circulation. Cardiovascular imaging. 2013 Sep 1. 755-61. FI: 5.795
Acute pancreatitis in a patient treated with liraglutide.
Artero A, Bourguet M, Lorente RI, Real JT
Medicina clínica. 2013 Oct 19. 368-9. FI: 1.399
Triptans in clinical practice: effectiveness, tolerance and patient's satisfaction with medication (TRIPRACLI study).
Lainez-Andres JM, Caminero A, Diaz-Insa S, Gracia-Naya M, Huerta-Villanueva M, Irimia P, Jimenez-Hernandez MD, Leira R, Sanchez del Rio-Gonzalez M
Revista de neurologia. 2013 Feb 1. 143-51. FI: 1.179
Analysis of post-infarction salvaged myocardium by cardiac magnetic resonance. Predictors and influence on adverse ventricular remodeling.
Monmeneu JV, Bodí V, López-Lereu MP, Sanchis J, Núñez J, Chaustre F, Husser O, Merlos P, Bonanad C, Miñana G, Chorro FJ, Llácer A
Revista española de cardiología. 2012 Jul. 634-41. FI: 2.53
Comments on "New epicardial mapping electrode with warming/cooling function for experimental electrophysiology studies" [33 (5) (2011) 653-659].
Tormos A, Guill A, Millet J, Roses EJ, Trapero I, Such-Miquel L, Chorro FJ
Medical engineering & physics. 2012 Jul. 796. FI: 1.779
Differential mortality association of loop diuretic dosage according to blood urea nitrogen and carbohydrate antigen 125 following a hospitalization for acute heart failure.
Núñez J, Núñez E, Miñana G, Bodí V, Fonarow GC, Bertomeu-González V, Palau P, Merlos P, Ventura S, Chorro FJ, Llàcer P, Sanchis J
European journal of heart failure. 2012 Sep. 974-84. FI: 5.247
Function of remote non-infarcted myocardium after STEMI: analysis with cardiovascular magnetic resonance.
Husser O, Chaustre F, Sanchis J, Nunez J, Monmeneu JV, Lopez-Lereu MP, Bonanad C, Gomez C, Oltra R, Llacer A, Riegger GA, Chorro FJ, Bodi V
The international journal of cardiovascular imaging. 2012 Dec. 2057-64. FI: 2.648
Heart rate and use of beta-blockers in stable outpatients with coronary artery disease.
Steg PG, Ferrari R, Ford I, Greenlaw N, Tardif JC, Tendera M, Abergel H, Fox KM, CLARIFY Investigators
. 2012. e36284. FI: 3.73
Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models.
Bodi V, Sanchis J, Morales JM, Marrachelli VG, Nunez J, Forteza MJ, Chaustre F, Gomez C, Mainar L, Minana G, Rumiz E, Husser O, Noguera I, Diaz A, Moratal D, Carratala A, Bosch X, Llacer A, Chorro FJ, Viña JR, Monleon D
Journal of the American College of Cardiology. 2012 May 1. 1629-41. FI: 14.086
Modifications in ventricular fibrillation and capture capacity induced by a linear radiofrequency lesion.
Chorro FJ, Pelechano F, Trapero I, Ibañez-Catalá X, Such-Miquel L, Tormos A, Guerrero J, Cánoves J, Mainar L, Millet J, Alberola A, Such L
Revista española de cardiología. 2012 Feb. 143-51. FI: 3.204
Prognostic Implications of Dipyridamole Cardiac MR Imaging: A Prospective Multicenter Registry.
Bodi V, Husser O, Sanchis J, Núñez J, Monmeneu JV, López-Lereu MP, Bosch MJ, Rumiz E, Miñana G, García C, Diago JL, Chaustre F, Moratal D, Gómez C, Aguilar J, Chorro FJ, Llacer A
Radiology. 2012 Jan. 91-100. FI: 6.339
Modifications of mechanoelectric feedback induced by 2,3-butanedione monoxime and Blebbistatin in Langendorff-perfused rabbit hearts.
Brines L, Such-Miquel L, Gallego D, Trapero I, Del Canto I, Zarzoso M, Soler C, Pelechano F, Cánoves J, Alberola A, Such L, Chorro FJ
Acta physiologica (Oxford, England). 2012 Sep. 29-41. FI: 4.382
Phase II trial of concomitant neoadjuvant chemotherapy with oxaliplatin and capecitabine and intensity-modulated radiotherapy (IMRT) in rectal cancer.
Gasent Blesa JM, Garde Noguera J, Laforga Canales JB, Giner Bosch V, Alberola A, Soler Tortosa M, Peris Godoy M, Sanchez JL, Provencio Pulla M, Alberola Candel V
Journal of gastrointestinal cancer. 2012 Dec. 553-61
Stable angina in Spain and its impact on quality of life. The AVANCE registry.
Borrás X, Garcia-Moll X, Gómez-Doblas JJ, Zapata A, Artigas R, AVANCE study researchers
Revista española de cardiología (English ed.). 2012 Aug. 734-41
The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity.
Zarzoso M, Such-Miquel L, Parra G, Brines-Ferrando L, Such L, Chorro FJ, Guerrero J, Guill A, O'Connor JE, Alberola A
European journal of applied physiology. 2012 Jun. 2185-93. FI: 2.66
Antigen carbohydrate 125 and brain natriuretic peptide serial measurements for risk stratification following an episode of acute heart failure.
Núñez J, Núñez E, Sanchis J, Bodí V, Fonarow GC, Miñana G, Palau P, Bertomeu-González V, Carratalá A, Mainar L, Chorro FJ, Llàcer A
International journal of cardiology. 2012 Aug 9. 43333. FI: 5.509
Carbohydrate antigen 125 serial measurements after an admission for acute heart failure and risk of early readmission.
Miñana Escrivá G, Núñez J, Sanchis J, Bodi V, Núñez E, Chorro FJ, Llàcer A
Medicina clínica. 2012 Nov 3. 479-86. FI: 1.399

Terapia génica del infarto agudo de miocardio mediante inyección hidrodinámica del gen humano IL-10 en el seno coronario del cerdo.

Referencia:
VLC BIOCLINIC TerGenlnf
Investigador principal:
Luis Mainar Latorre
Entidad financiadora:
Fundación Investigación Hospital Clínico Universitario de Valencia
Duración:
01/01/2015 - 31/12/2015
Presupuesto total:
€44.250